FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0239, 275 aa 1>>>pF1KE0239 275 - 275 aa - 275 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.7638+/-0.000323; mu= 18.2210+/- 0.020 mean_var=63.2739+/-12.886, 0's: 0 Z-trim(115.2): 13 B-trim: 1548 in 1/53 Lambda= 0.161236 statistics sampled from 25472 (25485) to 25472 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.683), E-opt: 0.2 (0.299), width: 16 Scan time: 7.070 The best scores are: opt bits E(85289) NP_741981 (OMIM: 605222) calcium-activated potassi ( 275) 1906 451.7 6.9e-127 NP_055222 (OMIM: 605222) calcium-activated potassi ( 279) 1783 423.1 2.9e-118 NP_741979 (OMIM: 605222) calcium-activated potassi ( 277) 1782 422.8 3.3e-118 NP_741980 (OMIM: 605222) calcium-activated potassi ( 257) 1775 421.2 9.8e-118 NP_001157149 (OMIM: 605222) calcium-activated pota ( 173) 911 220.1 2.3e-57 XP_011510627 (OMIM: 605214) PREDICTED: calcium-act ( 235) 633 155.5 8.5e-38 NP_852006 (OMIM: 605214) calcium-activated potassi ( 235) 633 155.5 8.5e-38 NP_005823 (OMIM: 605214) calcium-activated potassi ( 235) 633 155.5 8.5e-38 NP_001265840 (OMIM: 605214) calcium-activated pota ( 235) 633 155.5 8.5e-38 NP_055320 (OMIM: 605223) calcium-activated potassi ( 210) 479 119.7 4.7e-27 XP_011536490 (OMIM: 605223) PREDICTED: calcium-act ( 189) 368 93.8 2.6e-19 NP_004128 (OMIM: 603951,608622) calcium-activated ( 191) 235 62.9 5.3e-10 >>NP_741981 (OMIM: 605222) calcium-activated potassium c (275 aa) initn: 1906 init1: 1906 opt: 1906 Z-score: 2399.0 bits: 451.7 E(85289): 6.9e-127 Smith-Waterman score: 1906; 100.0% identity (100.0% similar) in 275 aa overlap (1-275:1-275) 10 20 30 40 50 60 pF1KE0 MFPLLYELTAVSPSPFPQRTAFPASGKKRETDYSDGDPLDVHKRLPSSAGEDRAVMLGFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_741 MFPLLYELTAVSPSPFPQRTAFPASGKKRETDYSDGDPLDVHKRLPSSAGEDRAVMLGFA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 MMGFSVLMFFLLGTTILKPFMLSIQREESTCTAIHTDIMDDWLDCAFTCGVHCHGQGKYP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_741 MMGFSVLMFFLLGTTILKPFMLSIQREESTCTAIHTDIMDDWLDCAFTCGVHCHGQGKYP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 CLQVFVNLSHPGQKALLHYNEEAVQINPKCFYTPKCHQDRNDLLNSALDIKEFFDHKNGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_741 CLQVFVNLSHPGQKALLHYNEEAVQINPKCFYTPKCHQDRNDLLNSALDIKEFFDHKNGT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 PFSCFYSPASQSEDVILIKKYDQMAIFHCLFWPSLTLLGGALIVGMVRLTQHLSLLCEKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_741 PFSCFYSPASQSEDVILIKKYDQMAIFHCLFWPSLTLLGGALIVGMVRLTQHLSLLCEKY 190 200 210 220 230 240 250 260 270 pF1KE0 STVVRDEVGGKVPYIEQHQFKLCIMRRSKGRAEKS ::::::::::::::::::::::::::::::::::: NP_741 STVVRDEVGGKVPYIEQHQFKLCIMRRSKGRAEKS 250 260 270 >>NP_055222 (OMIM: 605222) calcium-activated potassium c (279 aa) initn: 1783 init1: 1783 opt: 1783 Z-score: 2244.3 bits: 423.1 E(85289): 2.9e-118 Smith-Waterman score: 1783; 99.6% identity (100.0% similar) in 258 aa overlap (18-275:22-279) 10 20 30 40 50 pF1KE0 MFPLLYELTAVSPSPFPQRTAFPASGKKRETDYSDGDPLDVHKRLPSSAGEDRAVM .:::::::::::::::::::::::::::::::::::::: NP_055 MDFSPSSELGFHFVAFILLTRHRTAFPASGKKRETDYSDGDPLDVHKRLPSSAGEDRAVM 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE0 LGFAMMGFSVLMFFLLGTTILKPFMLSIQREESTCTAIHTDIMDDWLDCAFTCGVHCHGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 LGFAMMGFSVLMFFLLGTTILKPFMLSIQREESTCTAIHTDIMDDWLDCAFTCGVHCHGQ 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE0 GKYPCLQVFVNLSHPGQKALLHYNEEAVQINPKCFYTPKCHQDRNDLLNSALDIKEFFDH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 GKYPCLQVFVNLSHPGQKALLHYNEEAVQINPKCFYTPKCHQDRNDLLNSALDIKEFFDH 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE0 KNGTPFSCFYSPASQSEDVILIKKYDQMAIFHCLFWPSLTLLGGALIVGMVRLTQHLSLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 KNGTPFSCFYSPASQSEDVILIKKYDQMAIFHCLFWPSLTLLGGALIVGMVRLTQHLSLL 190 200 210 220 230 240 240 250 260 270 pF1KE0 CEKYSTVVRDEVGGKVPYIEQHQFKLCIMRRSKGRAEKS ::::::::::::::::::::::::::::::::::::::: NP_055 CEKYSTVVRDEVGGKVPYIEQHQFKLCIMRRSKGRAEKS 250 260 270 >>NP_741979 (OMIM: 605222) calcium-activated potassium c (277 aa) initn: 1782 init1: 1782 opt: 1782 Z-score: 2243.1 bits: 422.8 E(85289): 3.3e-118 Smith-Waterman score: 1782; 100.0% identity (100.0% similar) in 257 aa overlap (19-275:21-277) 10 20 30 40 50 pF1KE0 MFPLLYELTAVSPSPFPQRTAFPASGKKRETDYSDGDPLDVHKRLPSSAGEDRAVMLG :::::::::::::::::::::::::::::::::::::::: NP_741 MQPFSIPVQITLQGSRRRQGRTAFPASGKKRETDYSDGDPLDVHKRLPSSAGEDRAVMLG 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE0 FAMMGFSVLMFFLLGTTILKPFMLSIQREESTCTAIHTDIMDDWLDCAFTCGVHCHGQGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_741 FAMMGFSVLMFFLLGTTILKPFMLSIQREESTCTAIHTDIMDDWLDCAFTCGVHCHGQGK 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE0 YPCLQVFVNLSHPGQKALLHYNEEAVQINPKCFYTPKCHQDRNDLLNSALDIKEFFDHKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_741 YPCLQVFVNLSHPGQKALLHYNEEAVQINPKCFYTPKCHQDRNDLLNSALDIKEFFDHKN 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE0 GTPFSCFYSPASQSEDVILIKKYDQMAIFHCLFWPSLTLLGGALIVGMVRLTQHLSLLCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_741 GTPFSCFYSPASQSEDVILIKKYDQMAIFHCLFWPSLTLLGGALIVGMVRLTQHLSLLCE 190 200 210 220 230 240 240 250 260 270 pF1KE0 KYSTVVRDEVGGKVPYIEQHQFKLCIMRRSKGRAEKS ::::::::::::::::::::::::::::::::::::: NP_741 KYSTVVRDEVGGKVPYIEQHQFKLCIMRRSKGRAEKS 250 260 270 >>NP_741980 (OMIM: 605222) calcium-activated potassium c (257 aa) initn: 1775 init1: 1775 opt: 1775 Z-score: 2234.7 bits: 421.2 E(85289): 9.8e-118 Smith-Waterman score: 1775; 100.0% identity (100.0% similar) in 256 aa overlap (20-275:2-257) 10 20 30 40 50 60 pF1KE0 MFPLLYELTAVSPSPFPQRTAFPASGKKRETDYSDGDPLDVHKRLPSSAGEDRAVMLGFA ::::::::::::::::::::::::::::::::::::::::: NP_741 MTAFPASGKKRETDYSDGDPLDVHKRLPSSAGEDRAVMLGFA 10 20 30 40 70 80 90 100 110 120 pF1KE0 MMGFSVLMFFLLGTTILKPFMLSIQREESTCTAIHTDIMDDWLDCAFTCGVHCHGQGKYP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_741 MMGFSVLMFFLLGTTILKPFMLSIQREESTCTAIHTDIMDDWLDCAFTCGVHCHGQGKYP 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE0 CLQVFVNLSHPGQKALLHYNEEAVQINPKCFYTPKCHQDRNDLLNSALDIKEFFDHKNGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_741 CLQVFVNLSHPGQKALLHYNEEAVQINPKCFYTPKCHQDRNDLLNSALDIKEFFDHKNGT 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE0 PFSCFYSPASQSEDVILIKKYDQMAIFHCLFWPSLTLLGGALIVGMVRLTQHLSLLCEKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_741 PFSCFYSPASQSEDVILIKKYDQMAIFHCLFWPSLTLLGGALIVGMVRLTQHLSLLCEKY 170 180 190 200 210 220 250 260 270 pF1KE0 STVVRDEVGGKVPYIEQHQFKLCIMRRSKGRAEKS ::::::::::::::::::::::::::::::::::: NP_741 STVVRDEVGGKVPYIEQHQFKLCIMRRSKGRAEKS 230 240 250 >>NP_001157149 (OMIM: 605222) calcium-activated potassiu (173 aa) initn: 927 init1: 911 opt: 911 Z-score: 1150.9 bits: 220.1 E(85289): 2.3e-57 Smith-Waterman score: 911; 100.0% identity (100.0% similar) in 131 aa overlap (19-149:21-151) 10 20 30 40 50 pF1KE0 MFPLLYELTAVSPSPFPQRTAFPASGKKRETDYSDGDPLDVHKRLPSSAGEDRAVMLG :::::::::::::::::::::::::::::::::::::::: NP_001 MQPFSIPVQITLQGSRRRQGRTAFPASGKKRETDYSDGDPLDVHKRLPSSAGEDRAVMLG 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE0 FAMMGFSVLMFFLLGTTILKPFMLSIQREESTCTAIHTDIMDDWLDCAFTCGVHCHGQGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FAMMGFSVLMFFLLGTTILKPFMLSIQREESTCTAIHTDIMDDWLDCAFTCGVHCHGQGK 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE0 YPCLQVFVNLSHPGQKALLHYNEEAVQINPKCFYTPKCHQDRNDLLNSALDIKEFFDHKN ::::::::::::::::::::::::::::::: NP_001 YPCLQVFVNLSHPGQKALLHYNEEAVQINPKRDVTDCRVKEKQTLTVSDEHKQ 130 140 150 160 170 180 190 200 210 220 230 pF1KE0 GTPFSCFYSPASQSEDVILIKKYDQMAIFHCLFWPSLTLLGGALIVGMVRLTQHLSLLCE >>XP_011510627 (OMIM: 605214) PREDICTED: calcium-activat (235 aa) initn: 593 init1: 224 opt: 633 Z-score: 799.6 bits: 155.5 E(85289): 8.5e-38 Smith-Waterman score: 633; 43.9% identity (74.1% similar) in 212 aa overlap (35-245:27-235) 10 20 30 40 50 60 pF1KE0 LYELTAVSPSPFPQRTAFPASGKKRETDYSDGDPLDVHKRLPS-SAGEDRAVMLGFAMMG : : :: .: . . .::::::..::.::: XP_011 MFIWTSGRTSSSYRHDEKRNIYQKIRDHDLLDKRKTVTALKAGEDRAILLGLAMMV 10 20 30 40 50 70 80 90 100 110 120 pF1KE0 FSVLMFFLLGTTILKPFMLSIQREESTCTAIHTDIMDDWLDCAFTCGVHCHGQGKYPCLQ :..:.:::: :.:. .: :. ::: :: ....: . . .:.:.:: : ..::::: XP_011 CSIMMYFLLGITLLRSYMQSVWTEESQCTLLNASITETF-NCSFSCGPDCWKLSQYPCLQ 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE0 VFVNLSHPGQKALLHYNEEAVQINPKCFYTPKCHQDRNDLLNSALDIKEFFDHKNGTPFS :.:::. :.: ::...::...:: :: : ::: .. .. .. . . : : .. :: XP_011 VYVNLTSSGEKLLLYHTEETIKINQKCSYIPKCGKNFEESMSLVNVVMENF--RKYQHFS 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE0 CFYSPASQSEDVILIKKYDQMAIFHCLFWPSLTLLGGALIVGMVRLTQHLSLLCEKYSTV :. .: .....::: : :.. ..:: ::::. . ::. ::.::.:::.::::::. . . XP_011 CYSDPEGNQKSVILTKLYSSNVLFHSLFWPTCMMAGGVAIVAMVKLTQYLSLLCERIQRI 180 190 200 210 220 230 250 260 270 pF1KE0 VRDEVGGKVPYIEQHQFKLCIMRRSKGRAEKS : XP_011 NR >>NP_852006 (OMIM: 605214) calcium-activated potassium c (235 aa) initn: 593 init1: 224 opt: 633 Z-score: 799.6 bits: 155.5 E(85289): 8.5e-38 Smith-Waterman score: 633; 43.9% identity (74.1% similar) in 212 aa overlap (35-245:27-235) 10 20 30 40 50 60 pF1KE0 LYELTAVSPSPFPQRTAFPASGKKRETDYSDGDPLDVHKRLPS-SAGEDRAVMLGFAMMG : : :: .: . . .::::::..::.::: NP_852 MFIWTSGRTSSSYRHDEKRNIYQKIRDHDLLDKRKTVTALKAGEDRAILLGLAMMV 10 20 30 40 50 70 80 90 100 110 120 pF1KE0 FSVLMFFLLGTTILKPFMLSIQREESTCTAIHTDIMDDWLDCAFTCGVHCHGQGKYPCLQ :..:.:::: :.:. .: :. ::: :: ....: . . .:.:.:: : ..::::: NP_852 CSIMMYFLLGITLLRSYMQSVWTEESQCTLLNASITETF-NCSFSCGPDCWKLSQYPCLQ 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE0 VFVNLSHPGQKALLHYNEEAVQINPKCFYTPKCHQDRNDLLNSALDIKEFFDHKNGTPFS :.:::. :.: ::...::...:: :: : ::: .. .. .. . . : : .. :: NP_852 VYVNLTSSGEKLLLYHTEETIKINQKCSYIPKCGKNFEESMSLVNVVMENF--RKYQHFS 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE0 CFYSPASQSEDVILIKKYDQMAIFHCLFWPSLTLLGGALIVGMVRLTQHLSLLCEKYSTV :. .: .....::: : :.. ..:: ::::. . ::. ::.::.:::.::::::. . . NP_852 CYSDPEGNQKSVILTKLYSSNVLFHSLFWPTCMMAGGVAIVAMVKLTQYLSLLCERIQRI 180 190 200 210 220 230 250 260 270 pF1KE0 VRDEVGGKVPYIEQHQFKLCIMRRSKGRAEKS : NP_852 NR >>NP_005823 (OMIM: 605214) calcium-activated potassium c (235 aa) initn: 593 init1: 224 opt: 633 Z-score: 799.6 bits: 155.5 E(85289): 8.5e-38 Smith-Waterman score: 633; 43.9% identity (74.1% similar) in 212 aa overlap (35-245:27-235) 10 20 30 40 50 60 pF1KE0 LYELTAVSPSPFPQRTAFPASGKKRETDYSDGDPLDVHKRLPS-SAGEDRAVMLGFAMMG : : :: .: . . .::::::..::.::: NP_005 MFIWTSGRTSSSYRHDEKRNIYQKIRDHDLLDKRKTVTALKAGEDRAILLGLAMMV 10 20 30 40 50 70 80 90 100 110 120 pF1KE0 FSVLMFFLLGTTILKPFMLSIQREESTCTAIHTDIMDDWLDCAFTCGVHCHGQGKYPCLQ :..:.:::: :.:. .: :. ::: :: ....: . . .:.:.:: : ..::::: NP_005 CSIMMYFLLGITLLRSYMQSVWTEESQCTLLNASITETF-NCSFSCGPDCWKLSQYPCLQ 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE0 VFVNLSHPGQKALLHYNEEAVQINPKCFYTPKCHQDRNDLLNSALDIKEFFDHKNGTPFS :.:::. :.: ::...::...:: :: : ::: .. .. .. . . : : .. :: NP_005 VYVNLTSSGEKLLLYHTEETIKINQKCSYIPKCGKNFEESMSLVNVVMENF--RKYQHFS 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE0 CFYSPASQSEDVILIKKYDQMAIFHCLFWPSLTLLGGALIVGMVRLTQHLSLLCEKYSTV :. .: .....::: : :.. ..:: ::::. . ::. ::.::.:::.::::::. . . NP_005 CYSDPEGNQKSVILTKLYSSNVLFHSLFWPTCMMAGGVAIVAMVKLTQYLSLLCERIQRI 180 190 200 210 220 230 250 260 270 pF1KE0 VRDEVGGKVPYIEQHQFKLCIMRRSKGRAEKS : NP_005 NR >>NP_001265840 (OMIM: 605214) calcium-activated potassiu (235 aa) initn: 593 init1: 224 opt: 633 Z-score: 799.6 bits: 155.5 E(85289): 8.5e-38 Smith-Waterman score: 633; 43.9% identity (74.1% similar) in 212 aa overlap (35-245:27-235) 10 20 30 40 50 60 pF1KE0 LYELTAVSPSPFPQRTAFPASGKKRETDYSDGDPLDVHKRLPS-SAGEDRAVMLGFAMMG : : :: .: . . .::::::..::.::: NP_001 MFIWTSGRTSSSYRHDEKRNIYQKIRDHDLLDKRKTVTALKAGEDRAILLGLAMMV 10 20 30 40 50 70 80 90 100 110 120 pF1KE0 FSVLMFFLLGTTILKPFMLSIQREESTCTAIHTDIMDDWLDCAFTCGVHCHGQGKYPCLQ :..:.:::: :.:. .: :. ::: :: ....: . . .:.:.:: : ..::::: NP_001 CSIMMYFLLGITLLRSYMQSVWTEESQCTLLNASITETF-NCSFSCGPDCWKLSQYPCLQ 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE0 VFVNLSHPGQKALLHYNEEAVQINPKCFYTPKCHQDRNDLLNSALDIKEFFDHKNGTPFS :.:::. :.: ::...::...:: :: : ::: .. .. .. . . : : .. :: NP_001 VYVNLTSSGEKLLLYHTEETIKINQKCSYIPKCGKNFEESMSLVNVVMENF--RKYQHFS 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE0 CFYSPASQSEDVILIKKYDQMAIFHCLFWPSLTLLGGALIVGMVRLTQHLSLLCEKYSTV :. .: .....::: : :.. ..:: ::::. . ::. ::.::.:::.::::::. . . NP_001 CYSDPEGNQKSVILTKLYSSNVLFHSLFWPTCMMAGGVAIVAMVKLTQYLSLLCERIQRI 180 190 200 210 220 230 250 260 270 pF1KE0 VRDEVGGKVPYIEQHQFKLCIMRRSKGRAEKS : NP_001 NR >>NP_055320 (OMIM: 605223) calcium-activated potassium c (210 aa) initn: 456 init1: 316 opt: 479 Z-score: 606.7 bits: 119.7 E(85289): 4.7e-27 Smith-Waterman score: 479; 31.8% identity (74.5% similar) in 192 aa overlap (48-238:11-202) 20 30 40 50 60 70 pF1KE0 QRTAFPASGKKRETDYSDGDPLDVHKRLPSSAGEDRAVMLGFAMMGFSVLMFFLLGTTIL . .::... ::. .. .:. .:..: : NP_055 MAKLRVAYEYTEAEDKSIRLGLFLIISGVVSLFIFGFCWL 10 20 30 40 80 90 100 110 120 130 pF1KE0 KPFMLSIQREESTCTAIHTDIMDDWLDCAFTCGVHCHGQGKYPCLQVFVNLSHPGQKALL .: . ..: :..::.. .. . . ..:.::::. :.: ..:::.::.:: :. ...::: NP_055 SPALQDLQATEANCTVLSVQQIGEVFECTFTCGADCRGTSQYPCVQVYVNNSESNSRALL 50 60 70 80 90 100 140 150 160 170 180 190 pF1KE0 HYNEEAVQINPKCFYTPKCHQDRNDLLNSALDIKEFFDHKNGT-PFSCFYSPASQSEDVI : .:. . :::: : : :... . :.:... .... . :. ::.:... .. .::. NP_055 HSDEHQLLTNPKCSYIPPCKRENQKNLESVMNWQQYWKDEIGSQPFTCYFNQHQRPDDVL 110 120 130 140 150 160 200 210 220 230 240 250 pF1KE0 LIKKYDQMAIFHCLFWPSLTLLGGALIVGMVRLTQHLSLLCEKYSTVVRDEVGGKVPYIE : . .:.....::..:: .:.. :.::: .. .. :.. : NP_055 LHRTHDEIVLLHCFLWPLVTFVVGVLIVVLTICAKSLAVKAEAMKKRKFS 170 180 190 200 210 260 270 pF1KE0 QHQFKLCIMRRSKGRAEKS 275 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 19:47:28 2016 done: Thu Nov 3 19:47:29 2016 Total Scan time: 7.070 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]