FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0246, 418 aa 1>>>pF1KE0246 418 - 418 aa - 418 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.4814+/-0.000408; mu= 23.0362+/- 0.026 mean_var=110.5863+/-30.180, 0's: 0 Z-trim(112.8): 502 B-trim: 1282 in 1/52 Lambda= 0.121962 statistics sampled from 21125 (21819) to 21125 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.598), E-opt: 0.2 (0.256), width: 16 Scan time: 7.820 The best scores are: opt bits E(85289) NP_002522 (OMIM: 162651) neurotensin receptor type ( 418) 2743 494.0 2.8e-139 XP_011527129 (OMIM: 162651) PREDICTED: neurotensin ( 336) 2196 397.7 2.4e-110 XP_011508789 (OMIM: 604153) PREDICTED: neuromedin- ( 403) 621 120.6 6.9e-27 NP_006047 (OMIM: 604153) neuromedin-U receptor 1 [ ( 426) 621 120.7 7.1e-27 XP_006711940 (OMIM: 605538) PREDICTED: neurotensin ( 319) 609 118.4 2.6e-26 XP_006711939 (OMIM: 605538) PREDICTED: neurotensin ( 322) 609 118.4 2.6e-26 XP_016859227 (OMIM: 605538) PREDICTED: neurotensin ( 339) 609 118.4 2.7e-26 NP_036476 (OMIM: 605538) neurotensin receptor type ( 410) 604 117.7 5.5e-26 XP_005246213 (OMIM: 605538) PREDICTED: neurotensin ( 250) 538 105.7 1.3e-22 NP_004113 (OMIM: 601898) growth hormone secretagog ( 289) 443 89.1 1.5e-17 NP_940799 (OMIM: 601898) growth hormone secretagog ( 366) 440 88.7 2.5e-17 XP_011535972 (OMIM: 605108) PREDICTED: neuromedin- ( 321) 433 87.4 5.5e-17 NP_064552 (OMIM: 605108) neuromedin-U receptor 2 [ ( 415) 433 87.6 6.4e-17 XP_006712258 (OMIM: 604153) PREDICTED: neuromedin- ( 370) 421 85.4 2.6e-16 XP_011508790 (OMIM: 604153) PREDICTED: neuromedin- ( 376) 421 85.4 2.6e-16 NP_001498 (OMIM: 602885) motilin receptor [Homo sa ( 412) 419 85.1 3.5e-16 XP_011508791 (OMIM: 604153) PREDICTED: neuromedin- ( 313) 417 84.6 3.8e-16 XP_006712259 (OMIM: 604153) PREDICTED: neuromedin- ( 333) 417 84.6 4e-16 XP_011509323 (OMIM: 602886) PREDICTED: G-protein c ( 293) 408 83.0 1.1e-15 NP_001499 (OMIM: 602886) G-protein coupled recepto ( 453) 408 83.2 1.4e-15 XP_011515565 (OMIM: 188545) PREDICTED: thyrotropin ( 398) 393 80.5 8.2e-15 NP_003292 (OMIM: 188545) thyrotropin-releasing hor ( 398) 393 80.5 8.2e-15 NP_000697 (OMIM: 600821) vasopressin V1a receptor ( 418) 300 64.2 7.1e-10 NP_000015 (OMIM: 109690,600807,601665) beta-2 adre ( 413) 294 63.1 1.5e-09 NP_937822 (OMIM: 606925) pyroglutamylated RFamide ( 431) 292 62.8 1.9e-09 NP_000903 (OMIM: 165196) kappa-type opioid recepto ( 380) 286 61.7 3.7e-09 NP_001305426 (OMIM: 165196) kappa-type opioid rece ( 409) 286 61.7 3.9e-09 NP_872588 (OMIM: 602548) nociceptin receptor isofo ( 370) 282 60.9 6e-09 NP_001186948 (OMIM: 602548) nociceptin receptor is ( 370) 282 60.9 6e-09 NP_000904 (OMIM: 602548) nociceptin receptor isofo ( 370) 282 60.9 6e-09 XP_016883343 (OMIM: 602548) PREDICTED: nociceptin ( 370) 282 60.9 6e-09 XP_016883341 (OMIM: 602548) PREDICTED: nociceptin ( 388) 282 61.0 6.1e-09 XP_016883342 (OMIM: 602548) PREDICTED: nociceptin ( 388) 282 61.0 6.1e-09 XP_011527130 (OMIM: 602548) PREDICTED: nociceptin ( 388) 282 61.0 6.1e-09 NP_001305782 (OMIM: 602548) nociceptin receptor is ( 399) 282 61.0 6.2e-09 NP_000862 (OMIM: 601109) 5-hydroxytryptamine recep ( 440) 276 60.0 1.4e-08 NP_000670 (OMIM: 104220) alpha-1B adrenergic recep ( 520) 271 59.2 2.7e-08 NP_003605 (OMIM: 603692) galanin receptor type 3 [ ( 368) 268 58.5 3.3e-08 NP_001041 (OMIM: 182452) somatostatin receptor typ ( 369) 268 58.5 3.3e-08 NP_001043 (OMIM: 182454) somatostatin receptor typ ( 388) 267 58.3 3.8e-08 NP_005758 (OMIM: 278150,609239) lysophosphatidic a ( 344) 266 58.1 4e-08 NP_001155970 (OMIM: 278150,609239) lysophosphatidi ( 344) 266 58.1 4e-08 NP_001155969 (OMIM: 278150,609239) lysophosphatidi ( 344) 266 58.1 4e-08 XP_011534459 (OMIM: 606915) PREDICTED: probable G- ( 419) 265 58.0 5.1e-08 NP_110411 (OMIM: 606915) probable G-protein couple ( 419) 265 58.0 5.1e-08 XP_016866823 (OMIM: 606915) PREDICTED: probable G- ( 419) 265 58.0 5.1e-08 XP_011534457 (OMIM: 606915) PREDICTED: probable G- ( 419) 265 58.0 5.1e-08 NP_001137429 (OMIM: 606915) probable G-protein cou ( 419) 265 58.0 5.1e-08 XP_011534456 (OMIM: 606915) PREDICTED: probable G- ( 419) 265 58.0 5.1e-08 XP_011534461 (OMIM: 606915) PREDICTED: probable G- ( 419) 265 58.0 5.1e-08 >>NP_002522 (OMIM: 162651) neurotensin receptor type 1 [ (418 aa) initn: 2743 init1: 2743 opt: 2743 Z-score: 2621.4 bits: 494.0 E(85289): 2.8e-139 Smith-Waterman score: 2743; 100.0% identity (100.0% similar) in 418 aa overlap (1-418:1-418) 10 20 30 40 50 60 pF1KE0 MRLNSSAPGTPGTPAADPFQRAQAGLEEALLAPGFGNASGNASERVLAAPSSELDVNTDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MRLNSSAPGTPGTPAADPFQRAQAGLEEALLAPGFGNASGNASERVLAAPSSELDVNTDI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 YSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLTLLLAM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 YSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLTLLLAM 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 PVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 PVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 SRSRTKKFISAIWLASALLAVPMLFTMGEQNRSADGQHAGGLVCTPTIHTATVKVVIQVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 SRSRTKKFISAIWLASALLAVPMLFTMGEQNRSADGQHAGGLVCTPTIHTATVKVVIQVN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 TFMSFIFPMVVISVLNTIIANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 TFMSFIFPMVVISVLNTIIANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRH 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 GVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVTNALFYVSSTIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 GVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVTNALFYVSSTIN 310 320 330 340 350 360 370 380 390 400 410 pF1KE0 PILYNLVSANFRHIFLATLACLCPVWRRRRKRPAFSRKADSVSSNHTLSSNATRETLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 PILYNLVSANFRHIFLATLACLCPVWRRRRKRPAFSRKADSVSSNHTLSSNATRETLY 370 380 390 400 410 >>XP_011527129 (OMIM: 162651) PREDICTED: neurotensin rec (336 aa) initn: 2196 init1: 2196 opt: 2196 Z-score: 2102.2 bits: 397.7 E(85289): 2.4e-110 Smith-Waterman score: 2196; 100.0% identity (100.0% similar) in 336 aa overlap (1-336:1-336) 10 20 30 40 50 60 pF1KE0 MRLNSSAPGTPGTPAADPFQRAQAGLEEALLAPGFGNASGNASERVLAAPSSELDVNTDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MRLNSSAPGTPGTPAADPFQRAQAGLEEALLAPGFGNASGNASERVLAAPSSELDVNTDI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 YSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLTLLLAM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLTLLLAM 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 PVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 SRSRTKKFISAIWLASALLAVPMLFTMGEQNRSADGQHAGGLVCTPTIHTATVKVVIQVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SRSRTKKFISAIWLASALLAVPMLFTMGEQNRSADGQHAGGLVCTPTIHTATVKVVIQVN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 TFMSFIFPMVVISVLNTIIANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TFMSFIFPMVVISVLNTIIANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRH 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 GVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVTNALFYVSSTIN :::::::::::::::::::::::::::::::::::: XP_011 GVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTP 310 320 330 370 380 390 400 410 pF1KE0 PILYNLVSANFRHIFLATLACLCPVWRRRRKRPAFSRKADSVSSNHTLSSNATRETLY >>XP_011508789 (OMIM: 604153) PREDICTED: neuromedin-U re (403 aa) initn: 431 init1: 162 opt: 621 Z-score: 603.7 bits: 120.6 E(85289): 6.9e-27 Smith-Waterman score: 621; 31.5% identity (67.6% similar) in 340 aa overlap (66-397:40-368) 40 50 60 70 80 90 pF1KE0 GNASGNASERVLAAPSSELDVNTDIYSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQ . :.:: .::::.::: .: ... :.:... XP_011 GHFDPEDLNLTDEALRLKYLGPQQTELFMPICATYLLIFVVGAVGNGLTCLVILRHKAMR 10 20 30 40 50 60 100 110 120 130 140 150 pF1KE0 SLQSTVHYHLGSLALSDLLTLLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYAT . ..:.: :::.::::.::...:.:::. .: ..:. .: .:: .: . :. XP_011 T---PTNYYLFSLAVSDLLVLLVGLPLELYE-MWHNYPFLLGVGGCYFRTLLFEMVCLAS 70 80 90 100 110 120 160 170 180 190 200 210 pF1KE0 ALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAVPMLFTMG--EQNRS .:::..::::::.:. ::..:.....:..... ..:.: . : ..: : . . XP_011 VLNVTALSVERYVAVVHPLQARSMVTRAHVRRVLGAVWGLAMLCSLPNTSLHGIRQLHVP 130 140 150 160 170 180 220 230 240 250 260 270 pF1KE0 ADGQHAGGLVCTPTIHTATVKVVIQVNTFMSFIFPMVVISVLNTIIANKLT---VMVRQA : . :: . : ..:.:..... : .::...::: .:. .: ... : XP_011 CRGPVPDSAVCMLVRPRALYNMVVQTTALLFFCLPMAIMSVLYLLIGLRLRRERLLLMQE 190 200 210 220 230 240 280 290 300 310 320 330 pF1KE0 AEQGQVCTVGGEHSTFSMAIEPGRVQALRHGVRVLRAVVIAFVVCWLPYHVRRLMFCYIS :. .. .... . . :: :. ...: ..:..: .:: :.:. :.:. .: XP_011 AKGRGSAAARSRYTCRLQQHDRGR----RQVTKMLFVLVVVFGICWAPFHADRVMWSVVS 250 260 270 280 290 300 340 350 360 370 380 pF1KE0 DEQWTPFLYDFYHYFYMVTNALFYVSSTINPILYNLVSANFRHIFLATL---ACLCPVWR ::: :. ... ..... .::..:. ::.::.:.:. ::. : .: :: : : XP_011 --QWTDGLHLAFQHVHVISGIFFYLGSAANPVLYSLMSSRFRETFQEALCLGAC-CHRLR 310 320 330 340 350 390 400 410 pF1KE0 RRRKRPAFSRKADSVSSNHTLSSNATRETLY :.. ..:: XP_011 PRHSSHSLSRMTTGSTLCDVGSLGSWVHPLAGNDGPEAQQETDPS 360 370 380 390 400 >>NP_006047 (OMIM: 604153) neuromedin-U receptor 1 [Homo (426 aa) initn: 431 init1: 162 opt: 621 Z-score: 603.5 bits: 120.7 E(85289): 7.1e-27 Smith-Waterman score: 621; 31.5% identity (67.6% similar) in 340 aa overlap (66-397:63-391) 40 50 60 70 80 90 pF1KE0 GNASGNASERVLAAPSSELDVNTDIYSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQ . :.:: .::::.::: .: ... :.:... NP_006 GHFDPEDLNLTDEALRLKYLGPQQTELFMPICATYLLIFVVGAVGNGLTCLVILRHKAMR 40 50 60 70 80 90 100 110 120 130 140 150 pF1KE0 SLQSTVHYHLGSLALSDLLTLLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYAT . ..:.: :::.::::.::...:.:::. .: ..:. .: .:: .: . :. NP_006 T---PTNYYLFSLAVSDLLVLLVGLPLELYE-MWHNYPFLLGVGGCYFRTLLFEMVCLAS 100 110 120 130 140 160 170 180 190 200 210 pF1KE0 ALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAVPMLFTMG--EQNRS .:::..::::::.:. ::..:.....:..... ..:.: . : ..: : . . NP_006 VLNVTALSVERYVAVVHPLQARSMVTRAHVRRVLGAVWGLAMLCSLPNTSLHGIRQLHVP 150 160 170 180 190 200 220 230 240 250 260 270 pF1KE0 ADGQHAGGLVCTPTIHTATVKVVIQVNTFMSFIFPMVVISVLNTIIANKLT---VMVRQA : . :: . : ..:.:..... : .::...::: .:. .: ... : NP_006 CRGPVPDSAVCMLVRPRALYNMVVQTTALLFFCLPMAIMSVLYLLIGLRLRRERLLLMQE 210 220 230 240 250 260 280 290 300 310 320 330 pF1KE0 AEQGQVCTVGGEHSTFSMAIEPGRVQALRHGVRVLRAVVIAFVVCWLPYHVRRLMFCYIS :. .. .... . . :: :. ...: ..:..: .:: :.:. :.:. .: NP_006 AKGRGSAAARSRYTCRLQQHDRGR----RQVTKMLFVLVVVFGICWAPFHADRVMWSVVS 270 280 290 300 310 320 340 350 360 370 380 pF1KE0 DEQWTPFLYDFYHYFYMVTNALFYVSSTINPILYNLVSANFRHIFLATL---ACLCPVWR ::: :. ... ..... .::..:. ::.::.:.:. ::. : .: :: : : NP_006 --QWTDGLHLAFQHVHVISGIFFYLGSAANPVLYSLMSSRFRETFQEALCLGAC-CHRLR 330 340 350 360 370 380 390 400 410 pF1KE0 RRRKRPAFSRKADSVSSNHTLSSNATRETLY :.. ..:: NP_006 PRHSSHSLSRMTTGSTLCDVGSLGSWVHPLAGNDGPEAQQETDPS 390 400 410 420 >>XP_006711940 (OMIM: 605538) PREDICTED: neurotensin rec (319 aa) initn: 593 init1: 421 opt: 609 Z-score: 593.3 bits: 118.4 E(85289): 2.6e-26 Smith-Waterman score: 609; 39.8% identity (78.7% similar) in 221 aa overlap (52-269:21-239) 30 40 50 60 70 80 pF1KE0 AQAGLEEALLAPGFGNASGNASERVLAAPSSELDVNTDIYSKVLVTAVYLALFVVGTVGN ..: :.: ...::: ::.: ....:..:: XP_006 METSSPRPPRPSSNPGLSLDARLGVDTRLWAKVLFTALYALIWALGAAGN 10 20 30 40 50 90 100 110 120 130 140 pF1KE0 TVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLTLLLAMPVELYNFIWVHHPWAFGDAGC ...: .. . .. .. . ...:. ::::. :: ::...:::::.:.: :.::.::: :: XP_006 ALSAHVVLKARAGRA--GRLRHHVLSLALAGLLLLLVGVPVELYSFVWFHYPWVFGDLGC 60 70 80 90 100 150 160 170 180 190 200 pF1KE0 RGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAV :::::... :.:::.:.::.::.:: ::.:.:..:..:.. ::. ... : :: ::. XP_006 RGYYFVHELCAYATVLSVAGLSAERCLAVCQPLRARSLLTPRRTRWLVALSWAASLGLAL 110 120 130 140 150 160 210 220 230 240 250 pF1KE0 PMLFTMGEQNR--SADGQ-HAGGLVCTPTIHTATVKVVIQVNTFMSFIFPMVVISVLNTI :: ::.... .:::. . .. ::: . ....: ::::...::..:... . :: . XP_006 PMAVIMGQKHELETADGEPEPASRVCTVLVSRTALQVFIQVNVLVSFVLPLALTAFLNGV 170 180 190 200 210 220 260 270 280 290 300 310 pF1KE0 IANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRHGVRVLRAVVIAFVVCWLP ...: .. : XP_006 TVSHLLALCSQVPSTSTPGSSTPSRLELLSEEGLLSFIVWKKTFIQGGQEPSWSCMSSAG 230 240 250 260 270 280 >>XP_006711939 (OMIM: 605538) PREDICTED: neurotensin rec (322 aa) initn: 593 init1: 421 opt: 609 Z-score: 593.2 bits: 118.4 E(85289): 2.6e-26 Smith-Waterman score: 609; 39.8% identity (78.7% similar) in 221 aa overlap (52-269:21-239) 30 40 50 60 70 80 pF1KE0 AQAGLEEALLAPGFGNASGNASERVLAAPSSELDVNTDIYSKVLVTAVYLALFVVGTVGN ..: :.: ...::: ::.: ....:..:: XP_006 METSSPRPPRPSSNPGLSLDARLGVDTRLWAKVLFTALYALIWALGAAGN 10 20 30 40 50 90 100 110 120 130 140 pF1KE0 TVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLTLLLAMPVELYNFIWVHHPWAFGDAGC ...: .. . .. .. . ...:. ::::. :: ::...:::::.:.: :.::.::: :: XP_006 ALSAHVVLKARAGRA--GRLRHHVLSLALAGLLLLLVGVPVELYSFVWFHYPWVFGDLGC 60 70 80 90 100 150 160 170 180 190 200 pF1KE0 RGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAV :::::... :.:::.:.::.::.:: ::.:.:..:..:.. ::. ... : :: ::. XP_006 RGYYFVHELCAYATVLSVAGLSAERCLAVCQPLRARSLLTPRRTRWLVALSWAASLGLAL 110 120 130 140 150 160 210 220 230 240 250 pF1KE0 PMLFTMGEQNR--SADGQ-HAGGLVCTPTIHTATVKVVIQVNTFMSFIFPMVVISVLNTI :: ::.... .:::. . .. ::: . ....: ::::...::..:... . :: . XP_006 PMAVIMGQKHELETADGEPEPASRVCTVLVSRTALQVFIQVNVLVSFVLPLALTAFLNGV 170 180 190 200 210 220 260 270 280 290 300 310 pF1KE0 IANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRHGVRVLRAVVIAFVVCWLP ...: .. : XP_006 TVSHLLALCSQVPSTSTPGSSTPSRLELLSEEGLLSFIVWKKTFIQGGQVSLEPSWSCMS 230 240 250 260 270 280 >>XP_016859227 (OMIM: 605538) PREDICTED: neurotensin rec (339 aa) initn: 593 init1: 421 opt: 609 Z-score: 593.0 bits: 118.4 E(85289): 2.7e-26 Smith-Waterman score: 609; 39.8% identity (78.7% similar) in 221 aa overlap (52-269:21-239) 30 40 50 60 70 80 pF1KE0 AQAGLEEALLAPGFGNASGNASERVLAAPSSELDVNTDIYSKVLVTAVYLALFVVGTVGN ..: :.: ...::: ::.: ....:..:: XP_016 METSSPRPPRPSSNPGLSLDARLGVDTRLWAKVLFTALYALIWALGAAGN 10 20 30 40 50 90 100 110 120 130 140 pF1KE0 TVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLTLLLAMPVELYNFIWVHHPWAFGDAGC ...: .. . .. .. . ...:. ::::. :: ::...:::::.:.: :.::.::: :: XP_016 ALSAHVVLKARAGRA--GRLRHHVLSLALAGLLLLLVGVPVELYSFVWFHYPWVFGDLGC 60 70 80 90 100 150 160 170 180 190 200 pF1KE0 RGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAV :::::... :.:::.:.::.::.:: ::.:.:..:..:.. ::. ... : :: ::. XP_016 RGYYFVHELCAYATVLSVAGLSAERCLAVCQPLRARSLLTPRRTRWLVALSWAASLGLAL 110 120 130 140 150 160 210 220 230 240 250 pF1KE0 PMLFTMGEQNR--SADGQ-HAGGLVCTPTIHTATVKVVIQVNTFMSFIFPMVVISVLNTI :: ::.... .:::. . .. ::: . ....: ::::...::..:... . :: . XP_016 PMAVIMGQKHELETADGEPEPASRVCTVLVSRTALQVFIQVNVLVSFVLPLALTAFLNGV 170 180 190 200 210 220 260 270 280 290 300 310 pF1KE0 IANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRHGVRVLRAVVIAFVVCWLP ...: .. : XP_016 TVSHLLALCSQVPSTSTPGSSTPSRLELLSEEGLLSFIVWKKTFIQGGQVSLVRHKDVRR 230 240 250 260 270 280 >>NP_036476 (OMIM: 605538) neurotensin receptor type 2 [ (410 aa) initn: 1014 init1: 431 opt: 604 Z-score: 587.4 bits: 117.7 E(85289): 5.5e-26 Smith-Waterman score: 981; 39.3% identity (72.4% similar) in 384 aa overlap (52-403:21-400) 30 40 50 60 70 80 pF1KE0 AQAGLEEALLAPGFGNASGNASERVLAAPSSELDVNTDIYSKVLVTAVYLALFVVGTVGN ..: :.: ...::: ::.: ....:..:: NP_036 METSSPRPPRPSSNPGLSLDARLGVDTRLWAKVLFTALYALIWALGAAGN 10 20 30 40 50 90 100 110 120 130 140 pF1KE0 TVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLTLLLAMPVELYNFIWVHHPWAFGDAGC .... .. . .. .. . ...:. ::::. :: ::...:::::.:.: :.::.::: :: NP_036 ALSVHVVLKARAGRA--GRLRHHVLSLALAGLLLLLVGVPVELYSFVWFHYPWVFGDLGC 60 70 80 90 100 150 160 170 180 190 200 pF1KE0 RGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAV :::::... :.:::.:.::.::.:: ::.:.:..:..:.. ::. ... : :: ::. NP_036 RGYYFVHELCAYATVLSVAGLSAERCLAVCQPLRARSLLTPRRTRWLVALSWAASLGLAL 110 120 130 140 150 160 210 220 230 240 250 pF1KE0 PMLFTMGEQNR--SADGQ-HAGGLVCTPTIHTATVKVVIQVNTFMSFIFPMVVISVLNTI :: ::.... .:::. . .. ::: . ....: ::::...::..:... . :: . NP_036 PMAVIMGQKHELETADGEPEPASRVCTVLVSRTALQVFIQVNVLVSFVLPLALTAFLNGV 170 180 190 200 210 220 260 270 280 290 pF1KE0 IANKLTVMVRQA-----------------AEQGQVCTV--------GGEHSTFSMAIEPG ...: .. :. .:.: . . ::. : . NP_036 TVSHLLALCSQVPSTSTPGSSTPSRLELLSEEGLLSFIVWKKTFIQGGQVSLVRHK-DVR 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE0 RVQALRHGVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVTNALF :...:...:.::::.:. .:.::::::.::::.::. :. :: ::.::::::::::.:: NP_036 RIRSLQRSVQVLRAIVVMYVICWLPYHARRLMYCYVPDDAWTDPLYNFYHYFYMVTNTLF 290 300 310 320 330 340 360 370 380 390 400 pF1KE0 YVSSTINPILYNLVSANFRHIFLATLACLC----PVWRRRRKRPAFSRKADSVSSNHTLS ::::...:.::: ::..::..:: ... :: :. .: .: :..: NP_036 YVSSAVTPLLYNAVSSSFRKLFLEAVSSLCGEHHPM-KRLPPKPQSPTLMDTASGFGDPP 350 360 370 380 390 400 410 pF1KE0 SNATRETLY NP_036 ETRT 410 >>XP_005246213 (OMIM: 605538) PREDICTED: neurotensin rec (250 aa) initn: 522 init1: 421 opt: 538 Z-score: 526.8 bits: 105.7 E(85289): 1.3e-22 Smith-Waterman score: 538; 41.6% identity (78.9% similar) in 190 aa overlap (52-238:21-208) 30 40 50 60 70 80 pF1KE0 AQAGLEEALLAPGFGNASGNASERVLAAPSSELDVNTDIYSKVLVTAVYLALFVVGTVGN ..: :.: ...::: ::.: ....:..:: XP_005 METSSPRPPRPSSNPGLSLDARLGVDTRLWAKVLFTALYALIWALGAAGN 10 20 30 40 50 90 100 110 120 130 140 pF1KE0 TVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLTLLLAMPVELYNFIWVHHPWAFGDAGC ...: .. . .. .. . ...:. ::::. :: ::...:::::.:.: :.::.::: :: XP_005 ALSAHVVLKARAGRA--GRLRHHVLSLALAGLLLLLVGVPVELYSFVWFHYPWVFGDLGC 60 70 80 90 100 150 160 170 180 190 200 pF1KE0 RGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAV :::::... :.:::.:.::.::.:: ::.:.:..:..:.. ::. ... : :: ::. XP_005 RGYYFVHELCAYATVLSVAGLSAERCLAVCQPLRARSLLTPRRTRWLVALSWAASLGLAL 110 120 130 140 150 160 210 220 230 240 250 pF1KE0 PMLFTMGEQNR--SADGQ-HAGGLVCTPTIHTATVKVVIQVNTFMSFIFPMVVISVLNTI :: ::.... .:::. . .. ::: . ....: :: XP_005 PMAVIMGQKHELETADGEPEPASRVCTVLVSRTALQVFIQEPSWSCMSSAGCRTMPAGSC 170 180 190 200 210 220 260 270 280 290 300 310 pF1KE0 IANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRHGVRVLRAVVIAFVVCWLP XP_005 TATYLMTRGLTHCTISTTTSTW 230 240 250 >>NP_004113 (OMIM: 601898) growth hormone secretagogue r (289 aa) initn: 412 init1: 252 opt: 443 Z-score: 435.8 bits: 89.1 E(85289): 1.5e-17 Smith-Waterman score: 443; 33.9% identity (68.1% similar) in 257 aa overlap (66-318:46-287) 40 50 60 70 80 90 pF1KE0 GNASGNASERVLAAPSSELDVNTDIYSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQ :::. .:::::: .:: .: ....: .. NP_004 LADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSR---FR 20 30 40 50 60 70 100 110 120 130 140 150 pF1KE0 SLQSTVHYHLGSLALSDLLTLLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYAT :..:.. .:.:.:.:::: ..: ::..: .: ..:: ::: :. . :. ..::::: NP_004 ELRTTTNLYLSSMAFSDLL-IFLCMPLDLVR-LWQYRPWNFGDLLCKLFQFVSESCTYAT 80 90 100 110 120 130 160 170 180 190 200 210 pF1KE0 ALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAVPMLFTMG-EQNRSA .:....::::::.::: :..::......:.: : .:: .. : :.. .: :.. .. NP_004 VLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGT 140 150 160 170 180 190 220 230 240 250 260 270 pF1KE0 DGQHAGGLVCTPT---IHTATVKVVIQVNTFMSFIFPMVVISVLNTIIANKLTVMVRQAA : .. : :: .... . :.. :.... :..:. ..:: ..:. :: : : NP_004 DPWDTN--ECRPTEFAVRSGLLTVMVWVSSIF-FFLPVFCLTVLYSLIGRKLWRRRRGDA 200 210 220 230 240 280 290 300 310 320 330 pF1KE0 EQGQVCTVGGEHSTFSMAIEPGRVQALRHGVRVLRAVVIAFVVCWLPYHVRRLMFCYISD : ....: .: : .::: . : . .... : :: NP_004 VVGASLRDQNHKQTVKML--GGSQRALRLS---LAGPILSL--CLLPSL 250 260 270 280 340 350 360 370 380 390 pF1KE0 EQWTPFLYDFYHYFYMVTNALFYVSSTINPILYNLVSANFRHIFLATLACLCPVWRRRRK 418 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 19:21:27 2016 done: Thu Nov 3 19:21:28 2016 Total Scan time: 7.820 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]