FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0251, 89 aa 1>>>pF1KE0251 89 - 89 aa - 89 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.8176+/-0.000223; mu= 5.4007+/- 0.014 mean_var=151.7888+/-29.890, 0's: 0 Z-trim(128.4): 26 B-trim: 63 in 1/59 Lambda= 0.104101 statistics sampled from 59315 (59350) to 59315 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.922), E-opt: 0.2 (0.696), width: 16 Scan time: 4.690 The best scores are: opt bits E(85289) NP_848518 (OMIM: 612613) late cornified envelope p ( 89) 703 114.5 2.3e-26 NP_115952 (OMIM: 612616) late cornified envelope p ( 92) 546 90.9 3e-19 NP_848521 (OMIM: 612615) late cornified envelope p ( 94) 546 90.9 3e-19 NP_848520 (OMIM: 612614) late cornified envelope p ( 95) 536 89.4 8.7e-19 XP_011507786 (OMIM: 612617) PREDICTED: late cornif ( 92) 532 88.8 1.3e-18 NP_848522 (OMIM: 612617) late cornified envelope p ( 92) 532 88.8 1.3e-18 NP_848525 (OMIM: 612619) late cornified envelope p ( 118) 352 61.9 2.1e-10 NP_001263260 (OMIM: 612605) late cornified envelop ( 88) 324 57.6 3.2e-09 NP_848133 (OMIM: 612618) late cornified envelope p ( 99) 316 56.4 7.9e-09 XP_011507023 (OMIM: 612618) PREDICTED: late cornif ( 175) 292 53.0 1.4e-07 NP_848130 (OMIM: 612607) late cornified envelope p ( 118) 260 48.1 3e-06 NP_848128 (OMIM: 612605) late cornified envelope p ( 118) 253 47.0 6.3e-06 NP_848126 (OMIM: 612604) late cornified envelope p ( 118) 253 47.0 6.3e-06 NP_848515 (OMIM: 612609) late cornified envelope p ( 106) 242 45.3 1.8e-05 NP_848131 (OMIM: 612608) late cornified envelope p ( 118) 231 43.7 6.2e-05 NP_848516 (OMIM: 612611) late cornified envelope p ( 110) 230 43.5 6.6e-05 NP_848125 (OMIM: 612603) late cornified envelope p ( 110) 230 43.5 6.6e-05 NP_848517 (OMIM: 612612) late cornified envelope p ( 110) 229 43.4 7.3e-05 NP_055172 (OMIM: 612610) late cornified envelope p ( 110) 227 43.1 9e-05 NP_848129 (OMIM: 612606) late cornified envelope p ( 114) 223 42.5 0.00014 >>NP_848518 (OMIM: 612613) late cornified envelope prote (89 aa) initn: 703 init1: 703 opt: 703 Z-score: 594.2 bits: 114.5 E(85289): 2.3e-26 Smith-Waterman score: 703; 100.0% identity (100.0% similar) in 89 aa overlap (1-89:1-89) 10 20 30 40 50 60 pF1KE0 MSCQQNQQQCQPPPKCPAKSPAQCLPPASSSCAPSSGGCGPSSERSCCLSHHRCRRSHRC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_848 MSCQQNQQQCQPPPKCPAKSPAQCLPPASSSCAPSSGGCGPSSERSCCLSHHRCRRSHRC 10 20 30 40 50 60 70 80 pF1KE0 RCQSSNSCDRGSGQQGGSSSCGHSSAGCC ::::::::::::::::::::::::::::: NP_848 RCQSSNSCDRGSGQQGGSSSCGHSSAGCC 70 80 >>NP_115952 (OMIM: 612616) late cornified envelope prote (92 aa) initn: 393 init1: 270 opt: 546 Z-score: 466.6 bits: 90.9 E(85289): 3e-19 Smith-Waterman score: 546; 76.6% identity (86.2% similar) in 94 aa overlap (1-89:1-92) 10 20 30 40 50 pF1KE0 MSCQQNQQQCQPPPKCPA-----KSPAQCLPPASSSCAPSSGGCGPSSERSCCLSHHRCR :::::::::::::::::. :::.::::::::.::::::::::::: .: :.::: NP_115 MSCQQNQQQCQPPPKCPSPKCPPKSPVQCLPPASSGCAPSSGGCGPSSEGGCFLNHHR-- 10 20 30 40 50 60 70 80 pF1KE0 RSHRCRCQSSNSCDRGSGQQGGSSSCGHSSAGCC : :::: : ::::::::::::.:.:::.:.::: NP_115 RHHRCRRQRPNSCDRGSGQQGGGSGCGHGSGGCC 60 70 80 90 >>NP_848521 (OMIM: 612615) late cornified envelope prote (94 aa) initn: 468 init1: 468 opt: 546 Z-score: 466.5 bits: 90.9 E(85289): 3e-19 Smith-Waterman score: 546; 77.7% identity (84.0% similar) in 94 aa overlap (1-89:1-94) 10 20 30 40 50 pF1KE0 MSCQQNQQQCQPPP-----KCPAKSPAQCLPPASSSCAPSSGGCGPSSERSCCLSHHRCR :::::::::::::: ::: ::::::::: ::.:: :::::::::: .::::::: NP_848 MSCQQNQQQCQPPPSCPSPKCPPKSPAQCLPPPSSDCALSSGGCGPSSESGCCLSHHRHF 10 20 30 40 50 60 60 70 80 pF1KE0 RSHRCRCQSSNSCDRGSGQQGGSSSCGHSSAGCC :::.:: : :::::::::::::.: ::.:.::: NP_848 RSHQCRRQRSNSCDRGSGQQGGGSCRGHGSGGCC 70 80 90 >>NP_848520 (OMIM: 612614) late cornified envelope prote (95 aa) initn: 468 init1: 315 opt: 536 Z-score: 458.3 bits: 89.4 E(85289): 8.7e-19 Smith-Waterman score: 536; 76.8% identity (83.2% similar) in 95 aa overlap (1-89:1-95) 10 20 30 40 50 pF1KE0 MSCQQNQQQCQP-P----PKCPAKSPAQCLPPASSSCAPSSGGCG-PSSERSCCLSHHRC :::::::::::: : :::: :: ::::::::: ::: : :: :::: .:::::::: NP_848 MSCQQNQQQCQPLPKCPSPKCPPKSSAQCLPPASSCCAPRPGCCGGPSSEGGCCLSHHRC 10 20 30 40 50 60 60 70 80 pF1KE0 RRSHRCRCQSSNSCDRGSGQQGGSSSCGHSSAGCC :::::: ::::::::::::: :.:.::..:.::: NP_848 CRSHRCRRQSSNSCDRGSGQQDGASDCGYGSGGCC 70 80 90 >>XP_011507786 (OMIM: 612617) PREDICTED: late cornified (92 aa) initn: 383 init1: 266 opt: 532 Z-score: 455.2 bits: 88.8 E(85289): 1.3e-18 Smith-Waterman score: 532; 74.5% identity (86.2% similar) in 94 aa overlap (1-89:1-92) 10 20 30 40 50 pF1KE0 MSCQQNQQQCQPPPKCPA-----KSPAQCLPPASSSCAPSSGGCGPSSERSCCLSHHRCR :::::::.:::::::::. :.:.::::::::.::::::::::::: .: :.::: XP_011 MSCQQNQKQCQPPPKCPSPKCPPKNPVQCLPPASSGCAPSSGGCGPSSEGGCFLNHHR-- 10 20 30 40 50 60 70 80 pF1KE0 RSHRCRCQSSNSCDRGSGQQGGSSSCGHSSAGCC : :::: : :::::::::::::.:.: :.:.::: XP_011 RHHRCRRQRSNSCDRGSGQQGGGSGCCHGSGGCC 60 70 80 90 >>NP_848522 (OMIM: 612617) late cornified envelope prote (92 aa) initn: 383 init1: 266 opt: 532 Z-score: 455.2 bits: 88.8 E(85289): 1.3e-18 Smith-Waterman score: 532; 74.5% identity (86.2% similar) in 94 aa overlap (1-89:1-92) 10 20 30 40 50 pF1KE0 MSCQQNQQQCQPPPKCPA-----KSPAQCLPPASSSCAPSSGGCGPSSERSCCLSHHRCR :::::::.:::::::::. :.:.::::::::.::::::::::::: .: :.::: NP_848 MSCQQNQKQCQPPPKCPSPKCPPKNPVQCLPPASSGCAPSSGGCGPSSEGGCFLNHHR-- 10 20 30 40 50 60 70 80 pF1KE0 RSHRCRCQSSNSCDRGSGQQGGSSSCGHSSAGCC : :::: : :::::::::::::.:.: :.:.::: NP_848 RHHRCRRQRSNSCDRGSGQQGGGSGCCHGSGGCC 60 70 80 90 >>NP_848525 (OMIM: 612619) late cornified envelope prote (118 aa) initn: 634 init1: 329 opt: 352 Z-score: 307.8 bits: 61.9 E(85289): 2.1e-10 Smith-Waterman score: 391; 55.0% identity (63.1% similar) in 111 aa overlap (1-89:1-111) 10 20 30 40 pF1KE0 MSCQQNQQQCQPPPKC----------------PAKSPAQCL----PPASSSCAPSSGGCG :::::.:::::::::: : : : :: ::.:: :. ::::: NP_848 MSCQQSQQQCQPPPKCTPKCPPKCTPKCPPKCPPKCPPQCSAPCPPPVSSCCGSSSGGCC 10 20 30 40 50 60 50 60 70 80 pF1KE0 PSSERSCCLSHHRCRRSHRCRCQSSNSCDRGSGQQGGSSSCGHSS--AGCC : .::::::: :.: : : :::. : :::::.:.::: ::: .::: NP_848 SSEGGGCCLSHHRPRQSLRRRPQSSSCCGSGSGQQSGGSSCCHSSGGSGCCHSSGGCC 70 80 90 100 110 >>NP_001263260 (OMIM: 612605) late cornified envelope pr (88 aa) initn: 309 init1: 177 opt: 324 Z-score: 286.6 bits: 57.6 E(85289): 3.2e-09 Smith-Waterman score: 324; 53.8% identity (71.0% similar) in 93 aa overlap (1-89:1-88) 10 20 30 40 50 60 pF1KE0 MSCQQNQQQCQPPPKCPAKSPAQCLPPASSSCAPSSGGCGPSSERSCCLSHHRCRRSHRC :::::.::::::::. ..: . : ...::. ::::: :. .::::::: :::: NP_001 MSCQQSQQQCQPPPN--VSSGGCCGSSSGGSCGSSSGGCCSSGGGGCCLSHHRRRRSHCH 10 20 30 40 50 70 80 pF1KE0 RCQSSNSCDRGSGQQGGSSSCG----HSSAGCC : :::. :.. :: ::: :: . :.::: NP_001 RPQSSGCCSQPSG---GSSCCGGGSGQHSGGCC 60 70 80 >>NP_848133 (OMIM: 612618) late cornified envelope prote (99 aa) initn: 419 init1: 167 opt: 316 Z-score: 279.5 bits: 56.4 E(85289): 7.9e-09 Smith-Waterman score: 384; 58.0% identity (70.0% similar) in 100 aa overlap (1-89:1-99) 10 20 30 40 pF1KE0 MSCQQNQQQCQPPPKCPA-----KSPAQCL----PPASSSCAPSSGGCGPSSERS--CCL ::::::::::::::::: : :..: :: :: :. :::::: : .. ::: NP_848 MSCQQNQQQCQPPPKCPIPKYPPKCPSKCASSCPPPISSCCGSSSGGCGCCSSEGGGCCL 10 20 30 40 50 60 50 60 70 80 pF1KE0 SHHRCRRSHRCRCQSSNSCDRGSGQQGGSSSCGHSSAGCC :::: .::: : .::: :::::.:.:.: :..::: NP_848 SHHRHHRSHCHRPKSSNCYGSGSGQQSGGSGCC-SGGGCC 70 80 90 >>XP_011507023 (OMIM: 612618) PREDICTED: late cornified (175 aa) initn: 466 init1: 199 opt: 292 Z-score: 256.9 bits: 53.0 E(85289): 1.4e-07 Smith-Waterman score: 364; 55.7% identity (66.0% similar) in 106 aa overlap (1-89:71-175) 10 20 pF1KE0 MSCQQNQQQCQPPPKCPA-----KSPAQCL ::::::::::::::::: : :..: XP_011 FLLLASHLLCFLRDVSVAASEPTVYRNPTKMSCQQNQQQCQPPPKCPIPKYPPKCPSKCA 50 60 70 80 90 100 30 40 50 60 70 pF1KE0 ----PPASSSCAPSSGGCGPS-------SERS-CCLSHHRCRRSHRCRCQSSNSCDRGSG :: :: :. ::::: : :: . ::::::: .::: : .::: ::: XP_011 SSCPPPISSCCGSSSGGCCSSGGCGCCSSEGGGCCLSHHRHHRSHCHRPKSSNCYGSGSG 110 120 130 140 150 160 80 pF1KE0 QQGGSSSCGHSSAGCC ::.:.:.: :..::: XP_011 QQSGGSGCC-SGGGCC 170 89 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 19:09:35 2016 done: Thu Nov 3 19:09:36 2016 Total Scan time: 4.690 Total Display time: -0.030 Function used was FASTA [36.3.4 Apr, 2011]