FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0257, 399 aa 1>>>pF1KE0257 399 - 399 aa - 399 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.8288+/-0.000448; mu= 19.5537+/- 0.028 mean_var=94.3325+/-24.531, 0's: 0 Z-trim(110.6): 717 B-trim: 1823 in 2/46 Lambda= 0.132052 statistics sampled from 18191 (19045) to 18191 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.58), E-opt: 0.2 (0.223), width: 16 Scan time: 8.340 The best scores are: opt bits E(85289) NP_001718 (OMIM: 300107) bombesin receptor subtype ( 399) 2602 506.7 3.9e-143 NP_005305 (OMIM: 305670) gastrin-releasing peptide ( 384) 1292 257.2 5e-68 NP_002502 (OMIM: 162341) neuromedin-B receptor iso ( 390) 1195 238.7 1.9e-62 XP_011534148 (OMIM: 162341) PREDICTED: neuromedin- ( 283) 764 156.4 7.9e-38 XP_016866390 (OMIM: 162341) PREDICTED: neuromedin- ( 301) 757 155.1 2.1e-37 XP_016866391 (OMIM: 162341) PREDICTED: neuromedin- ( 242) 722 148.3 1.8e-35 NP_001311236 (OMIM: 162341) neuromedin-B receptor ( 242) 722 148.3 1.8e-35 NP_001311237 (OMIM: 162341) neuromedin-B receptor ( 242) 722 148.3 1.8e-35 NP_000106 (OMIM: 131244,277580,600155,600501) endo ( 442) 590 123.5 1e-27 NP_001116131 (OMIM: 131244,277580,600155,600501) e ( 442) 590 123.5 1e-27 NP_001188326 (OMIM: 131244,277580,600155,600501) e ( 532) 590 123.6 1.1e-27 NP_003982 (OMIM: 131244,277580,600155,600501) endo ( 436) 577 121.0 5.5e-27 NP_001948 (OMIM: 131243,157300,616367) endothelin- ( 427) 539 113.8 8.3e-25 XP_005263090 (OMIM: 162642) PREDICTED: neuropeptid ( 381) 525 111.0 4.9e-24 NP_000901 (OMIM: 162642) neuropeptide Y receptor t ( 381) 525 111.0 4.9e-24 XP_005263091 (OMIM: 162642) PREDICTED: neuropeptid ( 381) 525 111.0 4.9e-24 NP_937822 (OMIM: 606925) pyroglutamylated RFamide ( 431) 491 104.6 4.7e-22 XP_011538239 (OMIM: 601790) PREDICTED: neuropeptid ( 375) 490 104.4 4.9e-22 XP_011538238 (OMIM: 601790) PREDICTED: neuropeptid ( 375) 490 104.4 4.9e-22 XP_016871876 (OMIM: 601790) PREDICTED: neuropeptid ( 375) 490 104.4 4.9e-22 NP_001265723 (OMIM: 601790) neuropeptide Y recepto ( 375) 490 104.4 4.9e-22 NP_005963 (OMIM: 601790) neuropeptide Y receptor t ( 375) 490 104.4 4.9e-22 XP_016871875 (OMIM: 601790) PREDICTED: neuropeptid ( 375) 490 104.4 4.9e-22 NP_057624 (OMIM: 605569) probable G-protein couple ( 423) 490 104.4 5.3e-22 NP_444264 (OMIM: 607449) neuropeptide FF receptor ( 420) 486 103.7 8.9e-22 NP_001138228 (OMIM: 607449) neuropeptide FF recept ( 423) 486 103.7 9e-22 NP_004876 (OMIM: 607449) neuropeptide FF receptor ( 522) 486 103.8 1e-21 NP_071429 (OMIM: 607448) neuropeptide FF receptor ( 430) 468 100.2 9.8e-21 NP_000900 (OMIM: 162641) neuropeptide Y receptor t ( 384) 460 98.7 2.6e-20 XP_011530312 (OMIM: 162641) PREDICTED: neuropeptid ( 384) 460 98.7 2.6e-20 XP_005263088 (OMIM: 162641) PREDICTED: neuropeptid ( 384) 460 98.7 2.6e-20 NP_064552 (OMIM: 605108) neuromedin-U receptor 2 [ ( 415) 454 97.6 6.1e-20 NP_004239 (OMIM: 600895) prolactin-releasing pepti ( 370) 446 96.0 1.6e-19 NP_000903 (OMIM: 165196) kappa-type opioid recepto ( 380) 444 95.6 2.1e-19 NP_001305426 (OMIM: 165196) kappa-type opioid rece ( 409) 444 95.6 2.3e-19 NP_056542 (OMIM: 162323) substance-P receptor isof ( 311) 434 93.6 7.1e-19 NP_001048 (OMIM: 162321) substance-K receptor [Hom ( 398) 434 93.7 8.3e-19 NP_001049 (OMIM: 162323) substance-P receptor isof ( 407) 434 93.7 8.4e-19 XP_011527461 (OMIM: 244200,607123) PREDICTED: prok ( 348) 417 90.4 7.2e-18 XP_016883135 (OMIM: 244200,607123) PREDICTED: prok ( 384) 417 90.5 7.7e-18 NP_658986 (OMIM: 244200,607123) prokineticin recep ( 384) 417 90.5 7.7e-18 NP_115940 (OMIM: 176400,604161,614837) kiSS-1 rece ( 398) 414 89.9 1.2e-17 NP_005152 (OMIM: 600052) apelin receptor [Homo sap ( 380) 413 89.7 1.3e-17 XP_011535972 (OMIM: 605108) PREDICTED: neuromedin- ( 321) 403 87.7 4.3e-17 NP_620414 (OMIM: 607122) prokineticin receptor 1 [ ( 393) 390 85.3 2.7e-16 NP_005293 (OMIM: 602583) prosaposin receptor GPR37 ( 613) 388 85.2 4.7e-16 NP_001269833 (OMIM: 165196) kappa-type opioid rece ( 291) 381 83.5 7.4e-16 NP_000721 (OMIM: 118444) cholecystokinin receptor ( 428) 379 83.3 1.2e-15 XP_016881180 (OMIM: 600377) PREDICTED: galanin rec ( 269) 368 80.9 3.9e-15 NP_001471 (OMIM: 600377) galanin receptor type 1 [ ( 349) 363 80.1 9e-15 >>NP_001718 (OMIM: 300107) bombesin receptor subtype-3 [ (399 aa) initn: 2602 init1: 2602 opt: 2602 Z-score: 2690.8 bits: 506.7 E(85289): 3.9e-143 Smith-Waterman score: 2602; 100.0% identity (100.0% similar) in 399 aa overlap (1-399:1-399) 10 20 30 40 50 60 pF1KE0 MAQRQPHSPNQTLISITNDTESSSSVVSNDNTNKGWSGDNSPGIEALCAIYITYAVIISV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAQRQPHSPNQTLISITNDTESSSSVVSNDNTNKGWSGDNSPGIEALCAIYITYAVIISV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 GILGNAILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFGRIGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GILGNAILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFGRIGC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 KVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLERQPSNAILKTCVKAGCVWIVSMIFAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLERQPSNAILKTCVKAGCVWIVSMIFAL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 PEAIFSNVYTFRDPNKNMTFESCTSYPVSKKLLQEIHSLLCFLVFYIIPLSIISVYYSLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PEAIFSNVYTFRDPNKNMTFESCTSYPVSKKLLQEIHSLLCFLVFYIIPLSIISVYYSLI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 ARTLYKSTLNIPTEEQSHARKQIESRKRIARTVLVLVALFALCWLPNHLLYLYHSFTSQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ARTLYKSTLNIPTEEQSHARKQIESRKRIARTVLVLVALFALCWLPNHLLYLYHSFTSQT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 YVDPSAMHFIFTIFSRVLAFSNSCVNPFALYWLSKSFQKHFKAQLFCCKAERPEPPVADT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YVDPSAMHFIFTIFSRVLAFSNSCVNPFALYWLSKSFQKHFKAQLFCCKAERPEPPVADT 310 320 330 340 350 360 370 380 390 pF1KE0 SLTTLAVMGTVPGTGSIQMSEISVTSFTGCSVKQAEDRF ::::::::::::::::::::::::::::::::::::::: NP_001 SLTTLAVMGTVPGTGSIQMSEISVTSFTGCSVKQAEDRF 370 380 390 >>NP_005305 (OMIM: 305670) gastrin-releasing peptide rec (384 aa) initn: 1263 init1: 1047 opt: 1292 Z-score: 1342.2 bits: 257.2 E(85289): 5e-68 Smith-Waterman score: 1292; 58.6% identity (84.4% similar) in 326 aa overlap (24-349:22-341) 10 20 30 40 50 60 pF1KE0 MAQRQPHSPNQTLISITNDTESSSSVVSNDNTNKGWSGDNSPGIEALCAIYITYAVIISV :: .. .: :: ::: : .: .:.::: . NP_005 MALNDCFLLNLEVDHFMHCNISSHSADLPVNDDWS---HPGI--LYVIPAVYGVIILI 10 20 30 40 50 70 80 90 100 110 120 pF1KE0 GILGNAILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFGRIGC :..:: :::.: .:::..:::.::.:::.::::::.::.::::..:::. :::::::: NP_005 GLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLITCAPVDASRYLADRWLFGRIGC 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE0 KVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLERQPSNAILKTCVKAGCVWIVSMIFAL :.. ::.:::::::::::: ::::::::.:.:.. : :.:..: :.::. .::.::..:. NP_005 KLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMDIQASHALMKICLKAAFIWIISMLLAI 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE0 PEAIFSNVYTFRDPNKNMTFESCTSYPVSKKLLQEIHSLLCFLVFYIIPLSIISVYYSLI :::.::... :.. . :.:: ::. :: :..: .:::. :::::.:::::::::: .: NP_005 PEAVFSDLHPFHEESTNQTFISCAPYPHSNELHPKIHSMASFLVFYVIPLSIISVYYYFI 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE0 ARTLYKSTLNIPTEEQSHARKQIESRKRIARTVLVLVALFALCWLPNHLLYLYHSFTSQT :..: .:. :.:.: . :..::::::::.:.::::.:.:::.::::::..:::.:. . NP_005 AKNLIQSAYNLPVEGNIHVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSY-HYS 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE0 YVDPSAMHFIFTIFSRVLAFSNSCVNPFALYWLSKSFQKHFKAQLFCCKAERPEPPVADT :: : .::. .: .:.:::.:::::::::: :::::.:.:..::.::. NP_005 EVDTSMLHFVTSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPGLIIRSHSTG 300 310 320 330 340 350 370 380 390 pF1KE0 SLTTLAVMGTVPGTGSIQMSEISVTSFTGCSVKQAEDRF NP_005 RSTTCMTSLKSTNPSVATFSLINGNICHERYV 360 370 380 >>NP_002502 (OMIM: 162341) neuromedin-B receptor isoform (390 aa) initn: 1154 init1: 589 opt: 1195 Z-score: 1242.3 bits: 238.7 E(85289): 1.9e-62 Smith-Waterman score: 1195; 47.8% identity (75.9% similar) in 395 aa overlap (9-394:2-386) 10 20 30 40 50 pF1KE0 MAQRQPHSPNQTL--ISITNDTESSSSVVSNDNTNKGWSGDNSPGIEAL-------CAIY :...: .:.:. .. :.:: .:: : :. .. :.: NP_002 MPSKSLSNLSVTTGANESGSV------PEGWERDFLPASDGTTTELVIRCVIP 10 20 30 40 60 70 80 90 100 110 pF1KE0 ITYAVIISVGILGNAILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAE : .::.::.::: .:.:.:. ...:..::::::..:: ::::::::::::::..:. . NP_002 SLYLLIITVGLLGNIMLVKIFITNSAMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFD 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE0 GWLFGRIGCKVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLERQPSNAILKTCVKAGCV :.::..:::.. :.:::::::::::: ::::::.:.:.:.. : :.:.:.::::: . NP_002 EWMFGKVGCKLIPVIQLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGALLRTCVKAMGI 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE0 WIVSMIFALPEAIFSNVYTFRDPNKNMTFESCTSYPVSKKLLQEIHSLLCFLVFYIIPLS :.::...:.:::.::.: . . . : .: .: :: . .: .:::.: :::...:::. NP_002 WVVSVLLAVPEAVFSEVARISSLD-NSSFTACIPYPQTDELHPKIHSVLIFLVYFLIPLA 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE0 IISVYYSLIARTLYKSTLNIPTEEQSHARKQIESRKRIARTVLVLVALFALCWLPNHLLY :::.:: ::.:: ::. :.: : . :..::.:.:::.:. :::.:. : .::.:::.:: NP_002 IISIYYYHIAKTLIKSAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFIFCWFPNHILY 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE0 LYHSFTSQTYVDPSAMHFIFTIFSRVLAFSNSCVNPFALYWLSKSFQKHFKAQLFCCKAE .:.:: . . .::: :.: :. .:::.:.:::::::::: ::.::..::..:: :: . NP_002 MYRSF-NYNEIDPSLGHMIVTLVARVLSFGNSCVNPFALYLLSESFRRHFNSQL-CCGRK 290 300 310 320 330 340 360 370 380 390 pF1KE0 RPEPPVADTSLTTLAVMGTVPGTGSIQMSEISVTSFTGCSVKQAEDRF . .. :.. :: : ... .: :: ..: :.:: NP_002 SYQERGTSYLLSSSAVRMTSLKSNAKNMVTNSVL-LNGHSMKQEMAL 350 360 370 380 390 >>XP_011534148 (OMIM: 162341) PREDICTED: neuromedin-B re (283 aa) initn: 750 init1: 385 opt: 764 Z-score: 800.1 bits: 156.4 E(85289): 7.9e-38 Smith-Waterman score: 764; 47.2% identity (76.4% similar) in 250 aa overlap (145-394:34-279) 120 130 140 150 160 170 pF1KE0 FGRIGCKVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLERQPSNAILKTCVKAGCVWIV ::.:.:.:.. : :.:.:.::::: .:.: XP_011 VESLACFETTGEIVNFWTPIFRLDCLIWFRRYRAIVNPMDMQTSGALLRTCVKAMGIWVV 10 20 30 40 50 60 180 190 200 210 220 230 pF1KE0 SMIFALPEAIFSNVYTFRDPNKNMTFESCTSYPVSKKLLQEIHSLLCFLVFYIIPLSIIS :...:.:::.::.: . . . : .: .: :: . .: .:::.: :::...:::.::: XP_011 SVLLAVPEAVFSEVARISSLD-NSSFTACIPYPQTDELHPKIHSVLIFLVYFLIPLAIIS 70 80 90 100 110 120 240 250 260 270 280 290 pF1KE0 VYYSLIARTLYKSTLNIPTEEQSHARKQIESRKRIARTVLVLVALFALCWLPNHLLYLYH .:: ::.:: ::. :.: : . :..::.:.:::.:. :::.:. : .::.:::.::.:. XP_011 IYYYHIAKTLIKSAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFIFCWFPNHILYMYR 130 140 150 160 170 180 300 310 320 330 340 350 pF1KE0 SFTSQTYVDPSAMHFIFTIFSRVLAFSNSCVNPFALYWLSKSFQKHFKAQLFCCKAERPE :: . . .::: :.: :. .:::.:.:::::::::: ::.::..::..:: :: . . XP_011 SF-NYNEIDPSLGHMIVTLVARVLSFGNSCVNPFALYLLSESFRRHFNSQL-CCGRKSYQ 190 200 210 220 230 240 360 370 380 390 pF1KE0 PPVADTSLTTLAVMGTVPGTGSIQMSEISVTSFTGCSVKQAEDRF .. :.. :: : ... .: :: ..: :.:: XP_011 ERGTSYLLSSSAVRMTSLKSNAKNMVTNSVL-LNGHSMKQEMAL 250 260 270 280 >>XP_016866390 (OMIM: 162341) PREDICTED: neuromedin-B re (301 aa) initn: 743 init1: 385 opt: 757 Z-score: 792.6 bits: 155.1 E(85289): 2.1e-37 Smith-Waterman score: 757; 47.0% identity (76.3% similar) in 249 aa overlap (146-394:53-297) 120 130 140 150 160 170 pF1KE0 GRIGCKVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLERQPSNAILKTCVKAGCVWIVS :.:.:.:.. : :.:.:.::::: .:.:: XP_016 QGAWLSAVRTHRRPEHFGAYAAHGASALCWYRAIVNPMDMQTSGALLRTCVKAMGIWVVS 30 40 50 60 70 80 180 190 200 210 220 230 pF1KE0 MIFALPEAIFSNVYTFRDPNKNMTFESCTSYPVSKKLLQEIHSLLCFLVFYIIPLSIISV ...:.:::.::.: . . . : .: .: :: . .: .:::.: :::...:::.:::. XP_016 VLLAVPEAVFSEVARISSLD-NSSFTACIPYPQTDELHPKIHSVLIFLVYFLIPLAIISI 90 100 110 120 130 140 240 250 260 270 280 290 pF1KE0 YYSLIARTLYKSTLNIPTEEQSHARKQIESRKRIARTVLVLVALFALCWLPNHLLYLYHS :: ::.:: ::. :.: : . :..::.:.:::.:. :::.:. : .::.:::.::.:.: XP_016 YYYHIAKTLIKSAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFIFCWFPNHILYMYRS 150 160 170 180 190 200 300 310 320 330 340 350 pF1KE0 FTSQTYVDPSAMHFIFTIFSRVLAFSNSCVNPFALYWLSKSFQKHFKAQLFCCKAERPEP : . . .::: :.: :. .:::.:.:::::::::: ::.::..::..:: :: . . XP_016 F-NYNEIDPSLGHMIVTLVARVLSFGNSCVNPFALYLLSESFRRHFNSQL-CCGRKSYQE 210 220 230 240 250 360 370 380 390 pF1KE0 PVADTSLTTLAVMGTVPGTGSIQMSEISVTSFTGCSVKQAEDRF .. :.. :: : ... .: :: ..: :.:: XP_016 RGTSYLLSSSAVRMTSLKSNAKNMVTNSVL-LNGHSMKQEMAL 260 270 280 290 300 >>XP_016866391 (OMIM: 162341) PREDICTED: neuromedin-B re (242 aa) initn: 708 init1: 385 opt: 722 Z-score: 757.6 bits: 148.3 E(85289): 1.8e-35 Smith-Waterman score: 722; 46.7% identity (75.6% similar) in 242 aa overlap (153-394:1-238) 130 140 150 160 170 180 pF1KE0 LSFIRLTSVGVSVFTLTILSADRYKAVVKPLERQPSNAILKTCVKAGCVWIVSMIFALPE .. : :.:.:.::::: .:.::...:.:: XP_016 MDMQTSGALLRTCVKAMGIWVVSVLLAVPE 10 20 30 190 200 210 220 230 240 pF1KE0 AIFSNVYTFRDPNKNMTFESCTSYPVSKKLLQEIHSLLCFLVFYIIPLSIISVYYSLIAR :.::.: . . . : .: .: :: . .: .:::.: :::...:::.:::.:: ::. XP_016 AVFSEVARISSLD-NSSFTACIPYPQTDELHPKIHSVLIFLVYFLIPLAIISIYYYHIAK 40 50 60 70 80 250 260 270 280 290 300 pF1KE0 TLYKSTLNIPTEEQSHARKQIESRKRIARTVLVLVALFALCWLPNHLLYLYHSFTSQTYV :: ::. :.: : . :..::.:.:::.:. :::.:. : .::.:::.::.:.:: . . . XP_016 TLIKSAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFIFCWFPNHILYMYRSF-NYNEI 90 100 110 120 130 140 310 320 330 340 350 360 pF1KE0 DPSAMHFIFTIFSRVLAFSNSCVNPFALYWLSKSFQKHFKAQLFCCKAERPEPPVADTSL ::: :.: :. .:::.:.:::::::::: ::.::..::..:: :: . . .. : XP_016 DPSLGHMIVTLVARVLSFGNSCVNPFALYLLSESFRRHFNSQL-CCGRKSYQERGTSYLL 150 160 170 180 190 200 370 380 390 pF1KE0 TTLAVMGTVPGTGSIQMSEISVTSFTGCSVKQAEDRF .. :: : ... .: :: ..: :.:: XP_016 SSSAVRMTSLKSNAKNMVTNSVL-LNGHSMKQEMAL 210 220 230 240 >>NP_001311236 (OMIM: 162341) neuromedin-B receptor isof (242 aa) initn: 708 init1: 385 opt: 722 Z-score: 757.6 bits: 148.3 E(85289): 1.8e-35 Smith-Waterman score: 722; 46.7% identity (75.6% similar) in 242 aa overlap (153-394:1-238) 130 140 150 160 170 180 pF1KE0 LSFIRLTSVGVSVFTLTILSADRYKAVVKPLERQPSNAILKTCVKAGCVWIVSMIFALPE .. : :.:.:.::::: .:.::...:.:: NP_001 MDMQTSGALLRTCVKAMGIWVVSVLLAVPE 10 20 30 190 200 210 220 230 240 pF1KE0 AIFSNVYTFRDPNKNMTFESCTSYPVSKKLLQEIHSLLCFLVFYIIPLSIISVYYSLIAR :.::.: . . . : .: .: :: . .: .:::.: :::...:::.:::.:: ::. NP_001 AVFSEVARISSLD-NSSFTACIPYPQTDELHPKIHSVLIFLVYFLIPLAIISIYYYHIAK 40 50 60 70 80 250 260 270 280 290 300 pF1KE0 TLYKSTLNIPTEEQSHARKQIESRKRIARTVLVLVALFALCWLPNHLLYLYHSFTSQTYV :: ::. :.: : . :..::.:.:::.:. :::.:. : .::.:::.::.:.:: . . . NP_001 TLIKSAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFIFCWFPNHILYMYRSF-NYNEI 90 100 110 120 130 140 310 320 330 340 350 360 pF1KE0 DPSAMHFIFTIFSRVLAFSNSCVNPFALYWLSKSFQKHFKAQLFCCKAERPEPPVADTSL ::: :.: :. .:::.:.:::::::::: ::.::..::..:: :: . . .. : NP_001 DPSLGHMIVTLVARVLSFGNSCVNPFALYLLSESFRRHFNSQL-CCGRKSYQERGTSYLL 150 160 170 180 190 200 370 380 390 pF1KE0 TTLAVMGTVPGTGSIQMSEISVTSFTGCSVKQAEDRF .. :: : ... .: :: ..: :.:: NP_001 SSSAVRMTSLKSNAKNMVTNSVL-LNGHSMKQEMAL 210 220 230 240 >>NP_001311237 (OMIM: 162341) neuromedin-B receptor isof (242 aa) initn: 708 init1: 385 opt: 722 Z-score: 757.6 bits: 148.3 E(85289): 1.8e-35 Smith-Waterman score: 722; 46.7% identity (75.6% similar) in 242 aa overlap (153-394:1-238) 130 140 150 160 170 180 pF1KE0 LSFIRLTSVGVSVFTLTILSADRYKAVVKPLERQPSNAILKTCVKAGCVWIVSMIFALPE .. : :.:.:.::::: .:.::...:.:: NP_001 MDMQTSGALLRTCVKAMGIWVVSVLLAVPE 10 20 30 190 200 210 220 230 240 pF1KE0 AIFSNVYTFRDPNKNMTFESCTSYPVSKKLLQEIHSLLCFLVFYIIPLSIISVYYSLIAR :.::.: . . . : .: .: :: . .: .:::.: :::...:::.:::.:: ::. NP_001 AVFSEVARISSLD-NSSFTACIPYPQTDELHPKIHSVLIFLVYFLIPLAIISIYYYHIAK 40 50 60 70 80 250 260 270 280 290 300 pF1KE0 TLYKSTLNIPTEEQSHARKQIESRKRIARTVLVLVALFALCWLPNHLLYLYHSFTSQTYV :: ::. :.: : . :..::.:.:::.:. :::.:. : .::.:::.::.:.:: . . . NP_001 TLIKSAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFIFCWFPNHILYMYRSF-NYNEI 90 100 110 120 130 140 310 320 330 340 350 360 pF1KE0 DPSAMHFIFTIFSRVLAFSNSCVNPFALYWLSKSFQKHFKAQLFCCKAERPEPPVADTSL ::: :.: :. .:::.:.:::::::::: ::.::..::..:: :: . . .. : NP_001 DPSLGHMIVTLVARVLSFGNSCVNPFALYLLSESFRRHFNSQL-CCGRKSYQERGTSYLL 150 160 170 180 190 200 370 380 390 pF1KE0 TTLAVMGTVPGTGSIQMSEISVTSFTGCSVKQAEDRF .. :: : ... .: :: ..: :.:: NP_001 SSSAVRMTSLKSNAKNMVTNSVL-LNGHSMKQEMAL 210 220 230 240 >>NP_000106 (OMIM: 131244,277580,600155,600501) endothel (442 aa) initn: 545 init1: 348 opt: 590 Z-score: 618.7 bits: 123.5 E(85289): 1e-27 Smith-Waterman score: 590; 32.9% identity (67.4% similar) in 310 aa overlap (52-350:106-407) 30 40 50 60 70 80 pF1KE0 SSSSVVSNDNTNKGWSGDNSPGIEALCAIYITYAVIISVGILGNAILIKVFFKTKSMQTV .. ... .::.::. :.....:.: :.. NP_000 RTAGSPPRTISPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNG 80 90 100 110 120 130 90 100 110 120 130 140 pF1KE0 PNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFGRIGCKVLSFIRLTSVGVSVFTLTIL :::.:.:::.:::: .. .:... . ::: : :: ::.. ::. .:::..:..: : NP_000 PNILIASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFIQKASVGITVLSLCAL 140 150 160 170 180 190 150 160 170 180 190 200 pF1KE0 SADRYKAVVKPLERQPSNAILK-TCVKAGCVWIVSMIFALPEAIFSNVYTFRDPNKNMTF : :::.::.. : . .. : : :. .:.::...:.:::: .. :. :. . NP_000 SIDRYRAVAS-WSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDIITM--DYKGSYL 200 210 220 230 240 250 210 220 230 240 250 pF1KE0 ESCTSYPVSKKLLQEIHSLL----CFLVFYIIPLSIISVYYSLIARTLYKSTLNIPTEEQ . : .::.: ...... : .. .::.: . .:.:.. . .. .. . NP_000 RICLLHPVQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEMLRKKSGMQIALN 260 270 280 290 300 310 260 270 280 290 300 310 pF1KE0 SHARKQIESRKRIARTVLVLVALFALCWLPNHLLYLYHSFTSQTYVDPSAMHFI--FTIF .: .. :...:.::. :: .::::::: :: . . .: . ::. ... . .. NP_000 DHLKQ----RREVAKTVFCLVLVFALCWLPLHLSRILK-LTLYNQNDPNRCELLSFLLVL 320 330 340 350 360 320 330 340 350 360 370 pF1KE0 SRV---LAFSNSCVNPFALYWLSKSFQKHFKAQLFC-CKAERPEPPVADTSLTTLAVMGT . . .: :::.::.::: .:: :.. ::. : : :.. NP_000 DYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQSCLKFKAND 370 380 390 400 410 420 380 390 pF1KE0 VPGTGSIQMSEISVTSFTGCSVKQAEDRF NP_000 HGYDNFRSSNKYSSS 430 440 >>NP_001116131 (OMIM: 131244,277580,600155,600501) endot (442 aa) initn: 545 init1: 348 opt: 590 Z-score: 618.7 bits: 123.5 E(85289): 1e-27 Smith-Waterman score: 590; 32.9% identity (67.4% similar) in 310 aa overlap (52-350:106-407) 30 40 50 60 70 80 pF1KE0 SSSSVVSNDNTNKGWSGDNSPGIEALCAIYITYAVIISVGILGNAILIKVFFKTKSMQTV .. ... .::.::. :.....:.: :.. NP_001 RTAGSPPRTISPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNG 80 90 100 110 120 130 90 100 110 120 130 140 pF1KE0 PNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFGRIGCKVLSFIRLTSVGVSVFTLTIL :::.:.:::.:::: .. .:... . ::: : :: ::.. ::. .:::..:..: : NP_001 PNILIASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFIQKASVGITVLSLCAL 140 150 160 170 180 190 150 160 170 180 190 200 pF1KE0 SADRYKAVVKPLERQPSNAILK-TCVKAGCVWIVSMIFALPEAIFSNVYTFRDPNKNMTF : :::.::.. : . .. : : :. .:.::...:.:::: .. :. :. . NP_001 SIDRYRAVAS-WSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDIITM--DYKGSYL 200 210 220 230 240 250 210 220 230 240 250 pF1KE0 ESCTSYPVSKKLLQEIHSLL----CFLVFYIIPLSIISVYYSLIARTLYKSTLNIPTEEQ . : .::.: ...... : .. .::.: . .:.:.. . .. .. . NP_001 RICLLHPVQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEMLRKKSGMQIALN 260 270 280 290 300 310 260 270 280 290 300 310 pF1KE0 SHARKQIESRKRIARTVLVLVALFALCWLPNHLLYLYHSFTSQTYVDPSAMHFI--FTIF .: .. :...:.::. :: .::::::: :: . . .: . ::. ... . .. NP_001 DHLKQ----RREVAKTVFCLVLVFALCWLPLHLSRILK-LTLYNQNDPNRCELLSFLLVL 320 330 340 350 360 320 330 340 350 360 370 pF1KE0 SRV---LAFSNSCVNPFALYWLSKSFQKHFKAQLFC-CKAERPEPPVADTSLTTLAVMGT . . .: :::.::.::: .:: :.. ::. : : :.. NP_001 DYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQSCLKFKAND 370 380 390 400 410 420 380 390 pF1KE0 VPGTGSIQMSEISVTSFTGCSVKQAEDRF NP_001 HGYDNFRSSNKYSSS 430 440 399 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 18:47:39 2016 done: Thu Nov 3 18:47:41 2016 Total Scan time: 8.340 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]