FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0279, 208 aa 1>>>pF1KE0279 208 - 208 aa - 208 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.0652+/-0.00041; mu= 15.5674+/- 0.026 mean_var=84.5384+/-17.218, 0's: 0 Z-trim(114.1): 427 B-trim: 1215 in 2/52 Lambda= 0.139491 statistics sampled from 23353 (23820) to 23353 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.652), E-opt: 0.2 (0.279), width: 16 Scan time: 5.410 The best scores are: opt bits E(85289) XP_005247285 (OMIM: 608435) PREDICTED: ras-related ( 208) 1371 285.4 4.5e-77 XP_016861376 (OMIM: 608435) PREDICTED: ras-related ( 208) 1371 285.4 4.5e-77 NP_036351 (OMIM: 608435) ras-related protein M-Ras ( 208) 1371 285.4 4.5e-77 NP_001078518 (OMIM: 608435) ras-related protein M- ( 208) 1371 285.4 4.5e-77 NP_001239019 (OMIM: 608435) ras-related protein M- ( 208) 1371 285.4 4.5e-77 XP_005247286 (OMIM: 608435) PREDICTED: ras-related ( 170) 983 207.2 1.2e-53 NP_001239020 (OMIM: 608435) ras-related protein M- ( 132) 874 185.2 4.2e-47 NP_001239021 (OMIM: 608435) ras-related protein M- ( 132) 874 185.2 4.2e-47 NP_001239022 (OMIM: 608435) ras-related protein M- ( 132) 874 185.2 4.2e-47 NP_036382 (OMIM: 600098) ras-related protein R-Ras ( 204) 729 156.2 3.5e-38 NP_006261 (OMIM: 165090) ras-related protein R-Ras ( 218) 634 137.1 2.1e-32 XP_016872852 (OMIM: 600098) PREDICTED: ras-related ( 182) 618 133.8 1.7e-31 XP_011518955 (OMIM: 109800,114480,137215,163200,19 ( 188) 618 133.8 1.7e-31 NP_004976 (OMIM: 109800,114480,137215,163200,19007 ( 188) 618 133.8 1.7e-31 NP_001170785 (OMIM: 600098) ras-related protein R- ( 169) 610 132.2 4.9e-31 NP_001010935 (OMIM: 179520) ras-related protein Ra ( 184) 606 131.4 9.1e-31 XP_016857453 (OMIM: 179520) PREDICTED: ras-related ( 184) 606 131.4 9.1e-31 XP_016857451 (OMIM: 179520) PREDICTED: ras-related ( 184) 606 131.4 9.1e-31 NP_001278825 (OMIM: 179520) ras-related protein Ra ( 184) 606 131.4 9.1e-31 XP_016857452 (OMIM: 179520) PREDICTED: ras-related ( 184) 606 131.4 9.1e-31 NP_002875 (OMIM: 179520) ras-related protein Rap-1 ( 184) 606 131.4 9.1e-31 NP_203524 (OMIM: 109800,114480,137215,163200,19007 ( 189) 598 129.8 2.8e-30 XP_006719132 (OMIM: 109800,114480,137215,163200,19 ( 189) 598 129.8 2.8e-30 XP_016874782 (OMIM: 109800,114480,137215,163200,19 ( 227) 598 129.9 3.2e-30 NP_056461 (OMIM: 179530) ras-related protein Rap-1 ( 184) 596 129.4 3.7e-30 NP_001010942 (OMIM: 179530) ras-related protein Ra ( 184) 596 129.4 3.7e-30 NP_001123914 (OMIM: 109800,137550,162900,163200,18 ( 189) 592 128.6 6.5e-30 NP_005334 (OMIM: 109800,137550,162900,163200,18847 ( 189) 592 128.6 6.5e-30 NP_002515 (OMIM: 114500,137550,162900,163200,16479 ( 189) 583 126.8 2.3e-29 NP_002921 (OMIM: 609592) GTP-binding protein Rit2 ( 217) 583 126.8 2.5e-29 NP_008843 (OMIM: 609591,615355) GTP-binding protei ( 219) 581 126.4 3.4e-29 NP_001243750 (OMIM: 609591,615355) GTP-binding pro ( 236) 581 126.5 3.5e-29 NP_789765 (OMIM: 109800,137550,162900,163200,18847 ( 170) 555 121.1 1.1e-27 XP_006715825 (OMIM: 179550) PREDICTED: ras-related ( 206) 551 120.4 2.1e-27 XP_011513768 (OMIM: 179550) PREDICTED: ras-related ( 206) 551 120.4 2.1e-27 NP_005393 (OMIM: 179550) ras-related protein Ral-A ( 206) 551 120.4 2.1e-27 XP_016857449 (OMIM: 179520) PREDICTED: ras-related ( 195) 536 117.3 1.6e-26 XP_016857450 (OMIM: 179520) PREDICTED: ras-related ( 195) 536 117.3 1.6e-26 XP_016860111 (OMIM: 179551) PREDICTED: ras-related ( 206) 526 115.4 6.9e-26 NP_002872 (OMIM: 179551) ras-related protein Ral-B ( 206) 526 115.4 6.9e-26 XP_005263786 (OMIM: 179551) PREDICTED: ras-related ( 206) 526 115.4 6.9e-26 XP_005263785 (OMIM: 179551) PREDICTED: ras-related ( 206) 526 115.4 6.9e-26 XP_005263784 (OMIM: 179551) PREDICTED: ras-related ( 206) 526 115.4 6.9e-26 XP_016860110 (OMIM: 179551) PREDICTED: ras-related ( 228) 526 115.4 7.4e-26 XP_005263781 (OMIM: 179551) PREDICTED: ras-related ( 228) 526 115.4 7.4e-26 XP_011509875 (OMIM: 179551) PREDICTED: ras-related ( 229) 526 115.4 7.4e-26 NP_002877 (OMIM: 179541) ras-related protein Rap-2 ( 183) 513 112.7 3.9e-25 NP_066361 (OMIM: 179540) ras-related protein Rap-2 ( 183) 510 112.1 5.9e-25 NP_001243749 (OMIM: 609591,615355) GTP-binding pro ( 183) 504 110.9 1.4e-24 NP_001259006 (OMIM: 609592) GTP-binding protein Ri ( 153) 481 106.2 3e-23 >>XP_005247285 (OMIM: 608435) PREDICTED: ras-related pro (208 aa) initn: 1371 init1: 1371 opt: 1371 Z-score: 1504.7 bits: 285.4 E(85289): 4.5e-77 Smith-Waterman score: 1371; 100.0% identity (100.0% similar) in 208 aa overlap (1-208:1-208) 10 20 30 40 50 60 pF1KE0 MATSAVPSDNLPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTEIDNQW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MATSAVPSDNLPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTEIDNQW 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 AILDVLDTAGQEEFSAMREQYMRTGDGFLIVYSVTDKASFEHVDRFHQLILRVKDRESFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AILDVLDTAGQEEFSAMREQYMRTGDGFLIVYSVTDKASFEHVDRFHQLILRVKDRESFP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 MILVANKVDLMHLRKITREQGKEMATKHNIPYIETSAKDPPLNVDKAFHDLVRVIRQQIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MILVANKVDLMHLRKITREQGKEMATKHNIPYIETSAKDPPLNVDKAFHDLVRVIRQQIP 130 140 150 160 170 180 190 200 pF1KE0 EKSQKKKKKTKWRGDRATGTHKLQCVIL :::::::::::::::::::::::::::: XP_005 EKSQKKKKKTKWRGDRATGTHKLQCVIL 190 200 >>XP_016861376 (OMIM: 608435) PREDICTED: ras-related pro (208 aa) initn: 1371 init1: 1371 opt: 1371 Z-score: 1504.7 bits: 285.4 E(85289): 4.5e-77 Smith-Waterman score: 1371; 100.0% identity (100.0% similar) in 208 aa overlap (1-208:1-208) 10 20 30 40 50 60 pF1KE0 MATSAVPSDNLPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTEIDNQW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MATSAVPSDNLPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTEIDNQW 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 AILDVLDTAGQEEFSAMREQYMRTGDGFLIVYSVTDKASFEHVDRFHQLILRVKDRESFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AILDVLDTAGQEEFSAMREQYMRTGDGFLIVYSVTDKASFEHVDRFHQLILRVKDRESFP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 MILVANKVDLMHLRKITREQGKEMATKHNIPYIETSAKDPPLNVDKAFHDLVRVIRQQIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MILVANKVDLMHLRKITREQGKEMATKHNIPYIETSAKDPPLNVDKAFHDLVRVIRQQIP 130 140 150 160 170 180 190 200 pF1KE0 EKSQKKKKKTKWRGDRATGTHKLQCVIL :::::::::::::::::::::::::::: XP_016 EKSQKKKKKTKWRGDRATGTHKLQCVIL 190 200 >>NP_036351 (OMIM: 608435) ras-related protein M-Ras iso (208 aa) initn: 1371 init1: 1371 opt: 1371 Z-score: 1504.7 bits: 285.4 E(85289): 4.5e-77 Smith-Waterman score: 1371; 100.0% identity (100.0% similar) in 208 aa overlap (1-208:1-208) 10 20 30 40 50 60 pF1KE0 MATSAVPSDNLPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTEIDNQW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 MATSAVPSDNLPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTEIDNQW 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 AILDVLDTAGQEEFSAMREQYMRTGDGFLIVYSVTDKASFEHVDRFHQLILRVKDRESFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 AILDVLDTAGQEEFSAMREQYMRTGDGFLIVYSVTDKASFEHVDRFHQLILRVKDRESFP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 MILVANKVDLMHLRKITREQGKEMATKHNIPYIETSAKDPPLNVDKAFHDLVRVIRQQIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 MILVANKVDLMHLRKITREQGKEMATKHNIPYIETSAKDPPLNVDKAFHDLVRVIRQQIP 130 140 150 160 170 180 190 200 pF1KE0 EKSQKKKKKTKWRGDRATGTHKLQCVIL :::::::::::::::::::::::::::: NP_036 EKSQKKKKKTKWRGDRATGTHKLQCVIL 190 200 >>NP_001078518 (OMIM: 608435) ras-related protein M-Ras (208 aa) initn: 1371 init1: 1371 opt: 1371 Z-score: 1504.7 bits: 285.4 E(85289): 4.5e-77 Smith-Waterman score: 1371; 100.0% identity (100.0% similar) in 208 aa overlap (1-208:1-208) 10 20 30 40 50 60 pF1KE0 MATSAVPSDNLPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTEIDNQW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MATSAVPSDNLPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTEIDNQW 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 AILDVLDTAGQEEFSAMREQYMRTGDGFLIVYSVTDKASFEHVDRFHQLILRVKDRESFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AILDVLDTAGQEEFSAMREQYMRTGDGFLIVYSVTDKASFEHVDRFHQLILRVKDRESFP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 MILVANKVDLMHLRKITREQGKEMATKHNIPYIETSAKDPPLNVDKAFHDLVRVIRQQIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MILVANKVDLMHLRKITREQGKEMATKHNIPYIETSAKDPPLNVDKAFHDLVRVIRQQIP 130 140 150 160 170 180 190 200 pF1KE0 EKSQKKKKKTKWRGDRATGTHKLQCVIL :::::::::::::::::::::::::::: NP_001 EKSQKKKKKTKWRGDRATGTHKLQCVIL 190 200 >>NP_001239019 (OMIM: 608435) ras-related protein M-Ras (208 aa) initn: 1371 init1: 1371 opt: 1371 Z-score: 1504.7 bits: 285.4 E(85289): 4.5e-77 Smith-Waterman score: 1371; 100.0% identity (100.0% similar) in 208 aa overlap (1-208:1-208) 10 20 30 40 50 60 pF1KE0 MATSAVPSDNLPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTEIDNQW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MATSAVPSDNLPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTEIDNQW 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 AILDVLDTAGQEEFSAMREQYMRTGDGFLIVYSVTDKASFEHVDRFHQLILRVKDRESFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AILDVLDTAGQEEFSAMREQYMRTGDGFLIVYSVTDKASFEHVDRFHQLILRVKDRESFP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 MILVANKVDLMHLRKITREQGKEMATKHNIPYIETSAKDPPLNVDKAFHDLVRVIRQQIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MILVANKVDLMHLRKITREQGKEMATKHNIPYIETSAKDPPLNVDKAFHDLVRVIRQQIP 130 140 150 160 170 180 190 200 pF1KE0 EKSQKKKKKTKWRGDRATGTHKLQCVIL :::::::::::::::::::::::::::: NP_001 EKSQKKKKKTKWRGDRATGTHKLQCVIL 190 200 >>XP_005247286 (OMIM: 608435) PREDICTED: ras-related pro (170 aa) initn: 979 init1: 979 opt: 983 Z-score: 1083.8 bits: 207.2 E(85289): 1.2e-53 Smith-Waterman score: 983; 93.2% identity (96.3% similar) in 161 aa overlap (1-161:1-161) 10 20 30 40 50 60 pF1KE0 MATSAVPSDNLPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTEIDNQW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MATSAVPSDNLPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTEIDNQW 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 AILDVLDTAGQEEFSAMREQYMRTGDGFLIVYSVTDKASFEHVDRFHQLILRVKDRESFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AILDVLDTAGQEEFSAMREQYMRTGDGFLIVYSVTDKASFEHVDRFHQLILRVKDRESFP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 MILVANKVDLMHLRKITREQGKEMATKHNIPYIETSAKDPPLNVDKAFHDLVRVIRQQIP :::::::::::::::::::::::::::::. .. . . : XP_005 MILVANKVDLMHLRKITREQGKEMATKHNVDSVHRNQCQGPTSQCRQSLP 130 140 150 160 170 190 200 pF1KE0 EKSQKKKKKTKWRGDRATGTHKLQCVIL >>NP_001239020 (OMIM: 608435) ras-related protein M-Ras (132 aa) initn: 874 init1: 874 opt: 874 Z-score: 966.7 bits: 185.2 E(85289): 4.2e-47 Smith-Waterman score: 874; 100.0% identity (100.0% similar) in 132 aa overlap (77-208:1-132) 50 60 70 80 90 100 pF1KE0 EDSYLKHTEIDNQWAILDVLDTAGQEEFSAMREQYMRTGDGFLIVYSVTDKASFEHVDRF :::::::::::::::::::::::::::::: NP_001 MREQYMRTGDGFLIVYSVTDKASFEHVDRF 10 20 30 110 120 130 140 150 160 pF1KE0 HQLILRVKDRESFPMILVANKVDLMHLRKITREQGKEMATKHNIPYIETSAKDPPLNVDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HQLILRVKDRESFPMILVANKVDLMHLRKITREQGKEMATKHNIPYIETSAKDPPLNVDK 40 50 60 70 80 90 170 180 190 200 pF1KE0 AFHDLVRVIRQQIPEKSQKKKKKTKWRGDRATGTHKLQCVIL :::::::::::::::::::::::::::::::::::::::::: NP_001 AFHDLVRVIRQQIPEKSQKKKKKTKWRGDRATGTHKLQCVIL 100 110 120 130 >>NP_001239021 (OMIM: 608435) ras-related protein M-Ras (132 aa) initn: 874 init1: 874 opt: 874 Z-score: 966.7 bits: 185.2 E(85289): 4.2e-47 Smith-Waterman score: 874; 100.0% identity (100.0% similar) in 132 aa overlap (77-208:1-132) 50 60 70 80 90 100 pF1KE0 EDSYLKHTEIDNQWAILDVLDTAGQEEFSAMREQYMRTGDGFLIVYSVTDKASFEHVDRF :::::::::::::::::::::::::::::: NP_001 MREQYMRTGDGFLIVYSVTDKASFEHVDRF 10 20 30 110 120 130 140 150 160 pF1KE0 HQLILRVKDRESFPMILVANKVDLMHLRKITREQGKEMATKHNIPYIETSAKDPPLNVDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HQLILRVKDRESFPMILVANKVDLMHLRKITREQGKEMATKHNIPYIETSAKDPPLNVDK 40 50 60 70 80 90 170 180 190 200 pF1KE0 AFHDLVRVIRQQIPEKSQKKKKKTKWRGDRATGTHKLQCVIL :::::::::::::::::::::::::::::::::::::::::: NP_001 AFHDLVRVIRQQIPEKSQKKKKKTKWRGDRATGTHKLQCVIL 100 110 120 130 >>NP_001239022 (OMIM: 608435) ras-related protein M-Ras (132 aa) initn: 874 init1: 874 opt: 874 Z-score: 966.7 bits: 185.2 E(85289): 4.2e-47 Smith-Waterman score: 874; 100.0% identity (100.0% similar) in 132 aa overlap (77-208:1-132) 50 60 70 80 90 100 pF1KE0 EDSYLKHTEIDNQWAILDVLDTAGQEEFSAMREQYMRTGDGFLIVYSVTDKASFEHVDRF :::::::::::::::::::::::::::::: NP_001 MREQYMRTGDGFLIVYSVTDKASFEHVDRF 10 20 30 110 120 130 140 150 160 pF1KE0 HQLILRVKDRESFPMILVANKVDLMHLRKITREQGKEMATKHNIPYIETSAKDPPLNVDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HQLILRVKDRESFPMILVANKVDLMHLRKITREQGKEMATKHNIPYIETSAKDPPLNVDK 40 50 60 70 80 90 170 180 190 200 pF1KE0 AFHDLVRVIRQQIPEKSQKKKKKTKWRGDRATGTHKLQCVIL :::::::::::::::::::::::::::::::::::::::::: NP_001 AFHDLVRVIRQQIPEKSQKKKKKTKWRGDRATGTHKLQCVIL 100 110 120 130 >>NP_036382 (OMIM: 600098) ras-related protein R-Ras2 is (204 aa) initn: 713 init1: 644 opt: 729 Z-score: 806.6 bits: 156.2 E(85289): 3.5e-38 Smith-Waterman score: 729; 58.5% identity (82.1% similar) in 195 aa overlap (14-208:15-204) 10 20 30 40 50 pF1KE0 MATSAVPSDNLPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTEIDNQ :.::::: ::::::::::::.:. :: :::::::::: :. ::.. NP_036 MAAAGWRDGSGQEKYRLVVVGGGGVGKSALTIQFIQSYFVTDYDPTIEDSYTKQCVIDDR 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE0 WAILDVLDTAGQEEFSAMREQYMRTGDGFLIVYSVTDKASFEHVDRFHQLILRVKDRESF : ::.:::::::::.::::::::::.:::.:.::::..:::.. .:.. :::::::. : NP_036 AARLDILDTAGQEEFGAMREQYMRTGEGFLLVFSVTDRGSFEEIYKFQRQILRVKDRDEF 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE0 PMILVANKVDLMHLRKITREQGKEMATKHNIPYIETSAKDPPLNVDKAFHDLVRVIRQQI ::::..::.:: : :..:.:.:...: . .. :.:.::: .:::.:::.::::::. NP_036 PMILIGNKADLDHQRQVTQEEGQQLARQLKVTYMEASAK-IRMNVDQAFHELVRVIRKFQ 130 140 150 160 170 180 190 200 pF1KE0 PEKSQKKKKKTKWRGDRATGTHKLQCVIL .. . . :. . :. : : :::. NP_036 EQECPPSPEPTRKEKDKK-GCH---CVIF 180 190 200 208 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 17:53:10 2016 done: Thu Nov 3 17:53:11 2016 Total Scan time: 5.410 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]