FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0280, 71 aa 1>>>pF1KE0280 71 - 71 aa - 71 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.1561+/-0.000208; mu= 13.9912+/- 0.013 mean_var=53.9591+/-10.608, 0's: 0 Z-trim(125.8): 10 B-trim: 0 in 0/56 Lambda= 0.174599 statistics sampled from 50449 (50461) to 50449 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.897), E-opt: 0.2 (0.592), width: 16 Scan time: 3.500 The best scores are: opt bits E(85289) NP_697019 (OMIM: 616076) beta-defensin 123 precurs ( 67) 150 43.7 2.9e-05 NP_001011878 (OMIM: 616075) beta-defensin 121 isof ( 76) 136 40.2 0.00037 NP_695021 (OMIM: 615997) beta-defensin 119 isoform ( 84) 127 38.0 0.0019 NP_473453 (OMIM: 607650) beta-defensin 118 precurs ( 123) 125 37.6 0.0036 NP_001165303 (OMIM: 616075) beta-defensin 121 isof ( 64) 118 35.6 0.0075 XP_005260440 (OMIM: 616075) PREDICTED: beta-defens ( 64) 118 35.6 0.0075 >>NP_697019 (OMIM: 616076) beta-defensin 123 precursor [ (67 aa) initn: 196 init1: 110 opt: 150 Z-score: 215.5 bits: 43.7 E(85289): 2.9e-05 Smith-Waterman score: 150; 32.9% identity (62.9% similar) in 70 aa overlap (1-70:1-64) 10 20 30 40 50 60 pF1KE0 MTQLLLFLVALLVLGHVPSGRSEFKRCWKGQGACQTYCTRQETYMHLCPDASLCCLSYAL : ::: :..::.:... : .. :::. : :. :...: . : . ..::. NP_697 MKLLLLTLTVLLLLSQLTPGGTQ--RCWNLYGKCRYRCSKKERVYVYCINNKMCCV---- 10 20 30 40 50 70 pF1KE0 KPPPVPKHEYE :: ::... NP_697 KPKYQPKERWWPF 60 >>NP_001011878 (OMIM: 616075) beta-defensin 121 isoform (76 aa) initn: 135 init1: 112 opt: 136 Z-score: 195.7 bits: 40.2 E(85289): 0.00037 Smith-Waterman score: 136; 34.8% identity (60.6% similar) in 66 aa overlap (1-66:1-58) 10 20 30 40 50 60 pF1KE0 MTQLLLFLVALLVLGHVPSGRSEFKRCWKGQGACQTYCTRQETYMHLCPDASLCCLSYAL : :::.:.. :.:..: . .:: .: :.: : ..:.:. :: . ::.. NP_001 MKLLLLLLTVTLLLAQV----TPVMKCWGKSGRCRTTCKESEVYYILCKTEAKCCVD--- 10 20 30 40 50 70 pF1KE0 KPPPVPKHEYE : :: NP_001 -PKYVPVKPKLTDTNTSLESTSAV 60 70 >>NP_695021 (OMIM: 615997) beta-defensin 119 isoform a p (84 aa) initn: 135 init1: 102 opt: 127 Z-score: 182.9 bits: 38.0 E(85289): 0.0019 Smith-Waterman score: 127; 31.4% identity (60.0% similar) in 70 aa overlap (1-69:1-70) 10 20 30 40 50 pF1KE0 MTQLLLFLVALLVLGH-VPSGRSEFKRCWKGQGACQTYCTRQETYMHLCPDASLCCLSYA : : :::. ::.. . : ::. .. :: ..: :.. : ..: . : . . :::. NP_695 MKLLYLFLAILLAIEEPVISGKRHILRCMGNSGICRASCKKNEQPYLYCRNCQSCCLQSY 10 20 30 40 50 60 60 70 pF1KE0 LKPPPVPKHEYE .. :.: NP_695 MRISISGKEENTDWSYEKQWPRLP 70 80 >>NP_473453 (OMIM: 607650) beta-defensin 118 precursor [ (123 aa) initn: 125 init1: 125 opt: 125 Z-score: 178.0 bits: 37.6 E(85289): 0.0036 Smith-Waterman score: 125; 33.9% identity (53.6% similar) in 56 aa overlap (1-56:1-56) 10 20 30 40 50 60 pF1KE0 MTQLLLFLVALLVLGHVPSGRSEFKRCWKGQGACQTYCTRQETYMHLCPDASLCCLSYAL : ::: : :..: .: . : :.::. .: :. : :. : . ::. NP_473 MKLLLLALPMLVLLPQVIPAYSGEKKCWNRSGHCRKQCKDGEAVKDTCKNLRACCIPSNE 10 20 30 40 50 60 70 pF1KE0 KPPPVPKHEYE NP_473 DHRRVPATSPTPLSDSTPGIIDDILTVRFTTDYFEVSSKKDMVEESEAGRGTETSLPNVH 70 80 90 100 110 120 >>NP_001165303 (OMIM: 616075) beta-defensin 121 isoform (64 aa) initn: 126 init1: 109 opt: 118 Z-score: 172.2 bits: 35.6 E(85289): 0.0075 Smith-Waterman score: 118; 36.4% identity (59.1% similar) in 44 aa overlap (23-66:7-46) 10 20 30 40 50 60 pF1KE0 MTQLLLFLVALLVLGHVPSGRSEFKRCWKGQGACQTYCTRQETYMHLCPDASLCCLSYAL : .:: .: :.: : ..:.:. :: . ::.. NP_001 MFQEVKEVMKCWGKSGRCRTTCKESEVYYILCKTEAKCCVD--- 10 20 30 40 70 pF1KE0 KPPPVPKHEYE : :: NP_001 -PKYVPVKPKLTDTNTSLESTSAV 50 60 >>XP_005260440 (OMIM: 616075) PREDICTED: beta-defensin 1 (64 aa) initn: 126 init1: 109 opt: 118 Z-score: 172.2 bits: 35.6 E(85289): 0.0075 Smith-Waterman score: 118; 36.4% identity (59.1% similar) in 44 aa overlap (23-66:7-46) 10 20 30 40 50 60 pF1KE0 MTQLLLFLVALLVLGHVPSGRSEFKRCWKGQGACQTYCTRQETYMHLCPDASLCCLSYAL : .:: .: :.: : ..:.:. :: . ::.. XP_005 MFQEVKEVMKCWGKSGRCRTTCKESEVYYILCKTEAKCCVD--- 10 20 30 40 70 pF1KE0 KPPPVPKHEYE : :: XP_005 -PKYVPVKPKLTDTNTSLESTSAV 50 60 71 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 17:49:50 2016 done: Thu Nov 3 17:49:51 2016 Total Scan time: 3.500 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]