Result of FASTA (ccds) for
pF1KE0281
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0281, 234 aa
1>>>pF1KE0281 234 - 234 aa - 234 aa
Library: human.CCDS.faa
18511270 residues in 32554 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.6291+/-0.000755; mu= 15.4370+/- 0.046
mean_var=138.5750+/-26.284, 0's: 0 Z-trim(114.6): 46 B-trim: 5 in 1/50
Lambda= 0.108951
statistics sampled from 15136 (15182) to 15136 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.806), E-opt: 0.2 (0.466), width: 16
Scan time: 2.200
The best scores are: opt bits E(32554)
CCDS42846.1 RSPO4 gene_id:343637|Hs108|chr20 ( 234) 1748 285.2 2.5e-77
CCDS42845.1 RSPO4 gene_id:343637|Hs108|chr20 ( 172) 1012 169.3 1.4e-42
CCDS6307.1 RSPO2 gene_id:340419|Hs108|chr8 ( 243) 747 127.9 6e-30
CCDS5135.1 RSPO3 gene_id:84870|Hs108|chr6 ( 272) 667 115.3 3.9e-26
CCDS41304.1 RSPO1 gene_id:284654|Hs108|chr1 ( 263) 652 113.0 2e-25
CCDS55591.1 RSPO1 gene_id:284654|Hs108|chr1 ( 236) 628 109.1 2.5e-24
CCDS83314.1 RSPO2 gene_id:340419|Hs108|chr8 ( 176) 573 100.3 8.4e-22
CCDS55590.1 RSPO1 gene_id:284654|Hs108|chr1 ( 200) 456 82.0 3.1e-16
CCDS64953.1 RSPO2 gene_id:340419|Hs108|chr8 ( 179) 439 79.3 1.9e-15
>>CCDS42846.1 RSPO4 gene_id:343637|Hs108|chr20 (234 aa)
initn: 1748 init1: 1748 opt: 1748 Z-score: 1501.7 bits: 285.2 E(32554): 2.5e-77
Smith-Waterman score: 1748; 100.0% identity (100.0% similar) in 234 aa overlap (1-234:1-234)
10 20 30 40 50 60
pF1KE0 MRAPLCLLLLVAHAVDMLALNRRKKQVGTGLGGNCTGCIICSEENGCSTCQQRLFLFIRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 MRAPLCLLLLVAHAVDMLALNRRKKQVGTGLGGNCTGCIICSEENGCSTCQQRLFLFIRR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 EGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDFCIRCKRQFYLYKGKCLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 EGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDFCIRCKRQFYLYKGKCLP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 TCPPGTLAHQNTRECQGECELGPWGGWSPCTHNGKTCGSAWGLESRVREAGRAGHEEAAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 TCPPGTLAHQNTRECQGECELGPWGGWSPCTHNGKTCGSAWGLESRVREAGRAGHEEAAT
130 140 150 160 170 180
190 200 210 220 230
pF1KE0 CQVLSESRKCPIQRPCPGERSPGQKKGRKDRRPRKDRKLDRRLDVRPRQPGLQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 CQVLSESRKCPIQRPCPGERSPGQKKGRKDRRPRKDRKLDRRLDVRPRQPGLQP
190 200 210 220 230
>>CCDS42845.1 RSPO4 gene_id:343637|Hs108|chr20 (172 aa)
initn: 1256 init1: 1012 opt: 1012 Z-score: 877.9 bits: 169.3 E(32554): 1.4e-42
Smith-Waterman score: 1136; 73.5% identity (73.5% similar) in 234 aa overlap (1-234:1-172)
10 20 30 40 50 60
pF1KE0 MRAPLCLLLLVAHAVDMLALNRRKKQVGTGLGGNCTGCIICSEENGCSTCQQRLFLFIRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 MRAPLCLLLLVAHAVDMLALNRRKKQVGTGLGGNCTGCIICSEENGCSTCQQRLFLFIRR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 EGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDFCIRCKRQFYLYKGKCLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 EGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDFCIRCKRQFYLYKGKCLP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 TCPPGTLAHQNTRECQGECELGPWGGWSPCTHNGKTCGSAWGLESRVREAGRAGHEEAAT
::::::::::::::::
CCDS42 TCPPGTLAHQNTRECQ--------------------------------------------
130
190 200 210 220 230
pF1KE0 CQVLSESRKCPIQRPCPGERSPGQKKGRKDRRPRKDRKLDRRLDVRPRQPGLQP
::::::::::::::::::::::::::::::::::::
CCDS42 ------------------ERSPGQKKGRKDRRPRKDRKLDRRLDVRPRQPGLQP
140 150 160 170
>>CCDS6307.1 RSPO2 gene_id:340419|Hs108|chr8 (243 aa)
initn: 732 init1: 357 opt: 747 Z-score: 651.1 bits: 127.9 E(32554): 6e-30
Smith-Waterman score: 747; 46.1% identity (73.5% similar) in 204 aa overlap (22-222:27-227)
10 20 30 40 50
pF1KE0 MRAPLCLLLLVAHAVDMLALNRRKKQVGTGLGGNCTGCIICSEENGCSTCQQRLF
::.:... . : ::. ::..:::: :::.::
CCDS63 MQFRLFSFALIILNCMDYSHCQGNRWRRSKRASYVSNPICKGCLSCSKDNGCSRCQQKLF
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE0 LFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGA-TCESCFSQDFCIRCKRQFYLY
.:.::::.::::.:::.:: ::.: :. ..::: .: .:.::::.::: .:: :::.
CCDS63 FFLRREGMRQYGECLHSCPSGYYGHRAPDMNRCARCRIENCDSCFSKDFCTKCKVGFYLH
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE0 KGKCLPTCPPGTLAHQNTRECQGECELGPWGGWSPCTHNGKTCGSAWGLESRVREAGRAG
.:.:. :: : ..: :: ::.: :. :. :..:..::: ::::.:.:. .
CCDS63 RGRCFDECPDGFAPLEETMECVEGCEVGHWSEWGTCSRNNRTCGFKWGLETRTRQIVKKP
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE0 HEEAATCQVLSESRKCPI-QRPCPG-ERSPGQKKGRKDRRPRKDRKLDRRLDVRPRQPGL
... : ...:::.: . .: ::: .:.: :... : .: ::: .:
CCDS63 VKDTILCPTIAESRRCKMTMRHCPGGKRTP---KAKEKRNKKKKRKLIERAQEQHSVFLA
190 200 210 220 230
pF1KE0 QP
CCDS63 TDRANQ
240
>>CCDS5135.1 RSPO3 gene_id:84870|Hs108|chr6 (272 aa)
initn: 619 init1: 431 opt: 667 Z-score: 582.6 bits: 115.3 E(32554): 3.9e-26
Smith-Waterman score: 667; 43.3% identity (69.2% similar) in 201 aa overlap (22-217:28-225)
10 20 30 40 50
pF1KE0 MRAPLCLLLLVAHAVDMLALNRRKKQVGTGLGGNCTG-CIICSEENGCSTCQQR
::.... ... .: : : ::. ::: .:. :
CCDS51 MHLRLISWLFIILNFMEYIGSQNASRGRRQRRMHPNVSQGCQGGCATCSDYNGCLSCKPR
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE0 LFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDFCIRCKRQFYL
::. ..: :..: : :: .:: ::.: : ..:.: :: : :..::...:: .:: :::
CCDS51 LFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKSGFYL
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE0 YKGKCLPTCPPGTLAHQNTRECQG--ECELGPWGGWSPCTHNGKTCGSAWGLESRVREAG
. :::: .:: : :...: :: . .::.. :. :::::..::::: : :.::::
CCDS51 HLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREII
130 140 150 160 170 180
180 190 200 210 220
pF1KE0 RAGHEEAATCQVLSESRKCPIQRP-CP-GERSPGQKKGRKDRRPRKDRKLDRRLDVRPRQ
. .. : .:.::: .:: : :::. ::::. .: . ..
CCDS51 QHPSAKGNLCPPTNETRKCTVQRKKCQKGERG---KKGRERKRKKPNKGESKEAIPDSKS
190 200 210 220 230
230
pF1KE0 PGLQP
CCDS51 LESSKEIPEQRENKQQQKKRKVQDKQKSVSVSTVH
240 250 260 270
>>CCDS41304.1 RSPO1 gene_id:284654|Hs108|chr1 (263 aa)
initn: 554 init1: 245 opt: 652 Z-score: 570.1 bits: 113.0 E(32554): 2e-25
Smith-Waterman score: 652; 38.6% identity (68.2% similar) in 233 aa overlap (1-222:1-230)
10 20 30 40 50
pF1KE0 MRAPLCLLLLVAHAVDMLALNR-----RKKQVGTGLGGNCT-GCIICSEENGCSTCQQRL
:: ::.. :: . . .: :...... . :. :: .::: ::: :. .:
CCDS41 MRLGLCVVALVLSWTHLTISSRGIKGKRQRRISAEGSQACAKGCELCSEVNGCLKCSPKL
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE0 FLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGAT-CESCFSQDFCIRCKRQFYL
:....:. ::: : :: .:::::: :. ..:.: :: ::.:::..:: .::. .::
CCDS41 FILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKCKIEHCEACFSHNFCTKCKEGLYL
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE0 YKGKCLPTCPPGTLAHQNTRECQG--ECELGPWGGWSPCTHNGKTCGSAWGLESRVREAG
.::.: :.:: :. : ..: ::.. .::.. :. :.::... . :: : : :.:..
CCDS41 HKGRCYPACPEGSSAANGTMECSSPAQCEMSEWSPWGPCSKKQQLCGFRRGSEERTRRVL
130 140 150 160 170 180
180 190 200 210 220
pF1KE0 RAGHEEAATCQVLSESRKCPIQR-PCP-GERSPGQKKGRKDRRPRKDRKLDRRLDVRPRQ
.: . :.:. .:.:.: ..: ::: :.. ..:: . :: .:.: :.
CCDS41 HAPVGDHAACSDTKETRRCTVRRVPCPEGQK---RRKGGQGRRENANRNLARKESKEAGA
190 200 210 220 230
230
pF1KE0 PGLQP
CCDS41 GSRRRKGQQQQQQQGTVGPLTSAGPA
240 250 260
>>CCDS55591.1 RSPO1 gene_id:284654|Hs108|chr1 (236 aa)
initn: 530 init1: 245 opt: 628 Z-score: 550.2 bits: 109.1 E(32554): 2.5e-24
Smith-Waterman score: 628; 42.3% identity (71.6% similar) in 194 aa overlap (35-222:13-203)
10 20 30 40 50 60
pF1KE0 LCLLLLVAHAVDMLALNRRKKQVGTGLGGNCT-GCIICSEENGCSTCQQRLFLFIRREGI
:. :: .::: ::: :. .::....:. :
CCDS55 MIFRVSAEGSQACAKGCELCSEVNGCLKCSPKLFILLERNDI
10 20 30 40
70 80 90 100 110 120
pF1KE0 RQYGKCLHDCPPGYFGIRGQEVNRCKKCGAT-CESCFSQDFCIRCKRQFYLYKGKCLPTC
:: : :: .:::::: :. ..:.: :: ::.:::..:: .::. .::.::.: :.:
CCDS55 RQVGVCLPSCPPGYFDARNPDMNKCIKCKIEHCEACFSHNFCTKCKEGLYLHKGRCYPAC
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE0 PPGTLAHQNTRECQG--ECELGPWGGWSPCTHNGKTCGSAWGLESRVREAGRAGHEEAAT
: :. : ..: ::.. .::.. :. :.::... . :: : : :.:.. .: . :.
CCDS55 PEGSSAANGTMECSSPAQCEMSEWSPWGPCSKKQQLCGFRRGSEERTRRVLHAPVGDHAA
110 120 130 140 150 160
190 200 210 220 230
pF1KE0 CQVLSESRKCPIQR-PCP-GERSPGQKKGRKDRRPRKDRKLDRRLDVRPRQPGLQP
:. .:.:.: ..: ::: :.. ..:: . :: .:.: :.
CCDS55 CSDTKETRRCTVRRVPCPEGQK---RRKGGQGRRENANRNLARKESKEAGAGSRRRKGQQ
170 180 190 200 210
CCDS55 QQQQQGTVGPLTSAGPA
220 230
>>CCDS83314.1 RSPO2 gene_id:340419|Hs108|chr8 (176 aa)
initn: 581 init1: 357 opt: 573 Z-score: 504.9 bits: 100.3 E(32554): 8.4e-22
Smith-Waterman score: 573; 44.2% identity (71.8% similar) in 163 aa overlap (63-222:1-160)
40 50 60 70 80 90
pF1KE0 GNCTGCIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCG
.::::.:::.:: ::.: :. ..::: .:
CCDS83 MRQYGECLHSCPSGYYGHRAPDMNRCARCR
10 20 30
100 110 120 130 140 150
pF1KE0 A-TCESCFSQDFCIRCKRQFYLYKGKCLPTCPPGTLAHQNTRECQGECELGPWGGWSPCT
.:.::::.::: .:: :::..:.:. :: : ..: :: ::.: :. :. :.
CCDS83 IENCDSCFSKDFCTKCKVGFYLHRGRCFDECPDGFAPLEETMECVEGCEVGHWSEWGTCS
40 50 60 70 80 90
160 170 180 190 200
pF1KE0 HNGKTCGSAWGLESRVREAGRAGHEEAATCQVLSESRKCPI-QRPCPG-ERSPGQKKGRK
.:..::: ::::.:.:. . ... : ...:::.: . .: ::: .:.: :...
CCDS83 RNNRTCGFKWGLETRTRQIVKKPVKDTILCPTIAESRRCKMTMRHCPGGKRTP---KAKE
100 110 120 130 140
210 220 230
pF1KE0 DRRPRKDRKLDRRLDVRPRQPGLQP
: .: ::: .:
CCDS83 KRNKKKKRKLIERAQEQHSVFLATDRANQ
150 160 170
>>CCDS55590.1 RSPO1 gene_id:284654|Hs108|chr1 (200 aa)
initn: 476 init1: 245 opt: 456 Z-score: 404.9 bits: 82.0 E(32554): 3.1e-16
Smith-Waterman score: 456; 34.1% identity (62.4% similar) in 205 aa overlap (1-197:1-199)
10 20 30 40 50
pF1KE0 MRAPLCLLLLVAHAVDMLALNR-----RKKQVGTGLGGNCT-GCIICSEENGCSTCQQRL
:: ::.. :: . . .: :...... . :. :: .::: ::: :. .:
CCDS55 MRLGLCVVALVLSWTHLTISSRGIKGKRQRRISAEGSQACAKGCELCSEVNGCLKCSPKL
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE0 FLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGAT-CESCFSQDFCIRCKRQFYL
:....:. ::: : :: .:::::: :. ..:.: :: ::.:::..:: .::. .::
CCDS55 FILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKCKIEHCEACFSHNFCTKCKEGLYL
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE0 YKGKCLPTCPPGTLAHQNTRECQGECELGPWGGWSPCTHNGKTCGSAWGLESR-VREAGR
.::.: :.:: :. : ..: ::.. . :: .:. .. .: . .:::
CCDS55 HKGRCYPACPEGSSAANGTMECSSPGQKRRKGG------QGRRENANRNLARKESKEAGA
130 140 150 160 170
180 190 200 210 220 230
pF1KE0 AGHEEAATCQVLSESRKCPIQRPCPGERSPGQKKGRKDRRPRKDRKLDRRLDVRPRQPGL
..... . : ... :. :
CCDS55 GSRRRKGQQQQQQQGTVGPLTSAGPA
180 190 200
>>CCDS64953.1 RSPO2 gene_id:340419|Hs108|chr8 (179 aa)
initn: 416 init1: 193 opt: 439 Z-score: 391.0 bits: 79.3 E(32554): 1.9e-15
Smith-Waterman score: 439; 40.7% identity (68.0% similar) in 150 aa overlap (77-222:18-163)
50 60 70 80 90 100
pF1KE0 CSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKK-CGA-TCESCFSQDFC
: .:.. : :. : .:.::::.:::
CCDS64 MQFRLFSFALIILNCMDYSHCQGNRWRRSKRGCRIENCDSCFSKDFC
10 20 30 40
110 120 130 140 150 160
pF1KE0 IRCKRQFYLYKGKCLPTCPPGTLAHQNTRECQGECELGPWGGWSPCTHNGKTCGSAWGLE
.:: :::..:.:. :: : ..: :: : ::.: :. :. :..:..::: ::::
CCDS64 TKCKVGFYLHRGRCFDECPDGFAPLEETMECVG-CEVGHWSEWGTCSRNNRTCGFKWGLE
50 60 70 80 90 100
170 180 190 200 210 220
pF1KE0 SRVREAGRAGHEEAATCQVLSESRKCPI-QRPCPG-ERSPGQKKGRKDRRPRKDRKLDRR
.:.:. . ... : ...:::.: . .: ::: .:.: :... : .: ::: .:
CCDS64 TRTRQIVKKPVKDTILCPTIAESRRCKMTMRHCPGGKRTP---KAKEKRNKKKKRKLIER
110 120 130 140 150 160
230
pF1KE0 LDVRPRQPGLQP
CCDS64 AQEQHSVFLATDRANQ
170
234 residues in 1 query sequences
18511270 residues in 32554 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 17:48:05 2016 done: Thu Nov 3 17:48:05 2016
Total Scan time: 2.200 Total Display time: 0.020
Function used was FASTA [36.3.4 Apr, 2011]