FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0304, 489 aa 1>>>pF1KE0304 489 - 489 aa - 489 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.0503+/-0.000387; mu= 9.0850+/- 0.024 mean_var=99.9377+/-20.395, 0's: 0 Z-trim(114.5): 29 B-trim: 18 in 1/49 Lambda= 0.128295 statistics sampled from 24372 (24393) to 24372 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.658), E-opt: 0.2 (0.286), width: 16 Scan time: 8.820 The best scores are: opt bits E(85289) NP_114407 (OMIM: 616086,616200) sprT-like domain-c ( 489) 3297 621.0 2.4e-177 XP_006711881 (OMIM: 616086,616200) PREDICTED: sprT ( 446) 2268 430.5 4.7e-120 XP_011542591 (OMIM: 616086,616200) PREDICTED: sprT ( 361) 2265 429.9 5.7e-120 NP_001010984 (OMIM: 616086,616200) sprT-like domai ( 250) 1701 325.5 1.1e-88 NP_001248391 (OMIM: 616086,616200) sprT-like domai ( 207) 740 147.6 3.2e-35 >>NP_114407 (OMIM: 616086,616200) sprT-like domain-conta (489 aa) initn: 3297 init1: 3297 opt: 3297 Z-score: 3305.0 bits: 621.0 E(85289): 2.4e-177 Smith-Waterman score: 3297; 99.8% identity (99.8% similar) in 489 aa overlap (1-489:1-489) 10 20 30 40 50 60 pF1KE0 MDDDLMLALRLQEEWNLQEAERDHAQESLSLVDASWELVDPTPDLQALFVQFNDQFFWGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 MDDDLMLALRLQEEWNLQEAERDHAQESLSLVDASWELVDPTPDLQALFVQFNDQFFWGQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 LEAVEVKWSVRMTLCAGICSYEGKGGMCSIRLSEPLLKLRPRKDLVETLLHEMIHAYLFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 LEAVEVKWSVRMTLCAGICSYEGKGGMCSIRLSEPLLKLRPRKDLVETLLHEMIHAYLFV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 TNNDKDREGHGPEFCKHMHRINSLTGANITVYHTFHDEVDEYRRHWWRCNGPCQHRPPYY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 TNNDKDREGHGPEFCKHMHRINSLTGANITVYHTFHDEVDEYRRHWWRCNGPCQHRPPYY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 GYVKRATNREPSAHDYWWAEHQKTCGGTYIKIKEPENYSKKGKGKAKLGKEPVLAAENKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 GYVKRATNREPSAHDYWWAEHQKTCGGTYIKIKEPENYSKKGKGKAKLGKEPVLAAENKD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 KPNRGEAQLVIPFSGKGYVLGETSNLPSPGKLITSHAINKTQDLLNQNHSANAVRLNSKI ::::::::::::::::::::::::::::::::::::::::::::::::::::::: :::: NP_114 KPNRGEAQLVIPFSGKGYVLGETSNLPSPGKLITSHAINKTQDLLNQNHSANAVRPNSKI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 KVKFEQNGSSKNSHLVSPAVSNSHQNVLSNYFPRVSFANQKAFRGVNGSPRISVTVGNIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 KVKFEQNGSSKNSHLVSPAVSNSHQNVLSNYFPRVSFANQKAFRGVNGSPRISVTVGNIP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 KNSVSSSSQRRVSSSKISLRNSSKVTESASVMPSQDVSGSEDTFPNKRPRLEDKTVFDNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 KNSVSSSSQRRVSSSKISLRNSSKVTESASVMPSQDVSGSEDTFPNKRPRLEDKTVFDNF 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE0 FIKKEQIKSSGNDPKYSTTTAQNSSSSSSQSKMVNCPVCQNEVLESQINEHLDWCLEGDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 FIKKEQIKSSGNDPKYSTTTAQNSSSSSSQSKMVNCPVCQNEVLESQINEHLDWCLEGDS 430 440 450 460 470 480 pF1KE0 IKVKSEESL ::::::::: NP_114 IKVKSEESL >>XP_006711881 (OMIM: 616086,616200) PREDICTED: sprT-lik (446 aa) initn: 2268 init1: 2268 opt: 2268 Z-score: 2276.4 bits: 430.5 E(85289): 4.7e-120 Smith-Waterman score: 2903; 91.0% identity (91.0% similar) in 489 aa overlap (1-489:1-446) 10 20 30 40 50 60 pF1KE0 MDDDLMLALRLQEEWNLQEAERDHAQESLSLVDASWELVDPTPDLQALFVQFNDQFFWGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MDDDLMLALRLQEEWNLQEAERDHAQESLSLVDASWELVDPTPDLQALFVQFNDQFFWGQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 LEAVEVKWSVRMTLCAGICSYEGKGGMCSIRLSEPLLKLRPRKDLVETLLHEMIHAYLFV ::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LEAVEVKWSVRMTLCAGICSYEGKGGMCSIRLSEPLLKLRPRKDLVE------------- 70 80 90 100 130 140 150 160 170 180 pF1KE0 TNNDKDREGHGPEFCKHMHRINSLTGANITVYHTFHDEVDEYRRHWWRCNGPCQHRPPYY :::::::::::::::::::::::::::::: XP_006 ------------------------------VYHTFHDEVDEYRRHWWRCNGPCQHRPPYY 110 120 130 190 200 210 220 230 240 pF1KE0 GYVKRATNREPSAHDYWWAEHQKTCGGTYIKIKEPENYSKKGKGKAKLGKEPVLAAENKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GYVKRATNREPSAHDYWWAEHQKTCGGTYIKIKEPENYSKKGKGKAKLGKEPVLAAENKD 140 150 160 170 180 190 250 260 270 280 290 300 pF1KE0 KPNRGEAQLVIPFSGKGYVLGETSNLPSPGKLITSHAINKTQDLLNQNHSANAVRLNSKI ::::::::::::::::::::::::::::::::::::::::::::::::::::::: :::: XP_006 KPNRGEAQLVIPFSGKGYVLGETSNLPSPGKLITSHAINKTQDLLNQNHSANAVRPNSKI 200 210 220 230 240 250 310 320 330 340 350 360 pF1KE0 KVKFEQNGSSKNSHLVSPAVSNSHQNVLSNYFPRVSFANQKAFRGVNGSPRISVTVGNIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KVKFEQNGSSKNSHLVSPAVSNSHQNVLSNYFPRVSFANQKAFRGVNGSPRISVTVGNIP 260 270 280 290 300 310 370 380 390 400 410 420 pF1KE0 KNSVSSSSQRRVSSSKISLRNSSKVTESASVMPSQDVSGSEDTFPNKRPRLEDKTVFDNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KNSVSSSSQRRVSSSKISLRNSSKVTESASVMPSQDVSGSEDTFPNKRPRLEDKTVFDNF 320 330 340 350 360 370 430 440 450 460 470 480 pF1KE0 FIKKEQIKSSGNDPKYSTTTAQNSSSSSSQSKMVNCPVCQNEVLESQINEHLDWCLEGDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 FIKKEQIKSSGNDPKYSTTTAQNSSSSSSQSKMVNCPVCQNEVLESQINEHLDWCLEGDS 380 390 400 410 420 430 pF1KE0 IKVKSEESL ::::::::: XP_006 IKVKSEESL 440 >>XP_011542591 (OMIM: 616086,616200) PREDICTED: sprT-lik (361 aa) initn: 2265 init1: 2265 opt: 2265 Z-score: 2274.8 bits: 429.9 E(85289): 5.7e-120 Smith-Waterman score: 2265; 99.7% identity (99.7% similar) in 339 aa overlap (151-489:23-361) 130 140 150 160 170 180 pF1KE0 TNNDKDREGHGPEFCKHMHRINSLTGANITVYHTFHDEVDEYRRHWWRCNGPCQHRPPYY :::::::::::::::::::::::::::::: XP_011 MAAEPVISLRPLTSSESTFYTQVYHTFHDEVDEYRRHWWRCNGPCQHRPPYY 10 20 30 40 50 190 200 210 220 230 240 pF1KE0 GYVKRATNREPSAHDYWWAEHQKTCGGTYIKIKEPENYSKKGKGKAKLGKEPVLAAENKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GYVKRATNREPSAHDYWWAEHQKTCGGTYIKIKEPENYSKKGKGKAKLGKEPVLAAENKD 60 70 80 90 100 110 250 260 270 280 290 300 pF1KE0 KPNRGEAQLVIPFSGKGYVLGETSNLPSPGKLITSHAINKTQDLLNQNHSANAVRLNSKI ::::::::::::::::::::::::::::::::::::::::::::::::::::::: :::: XP_011 KPNRGEAQLVIPFSGKGYVLGETSNLPSPGKLITSHAINKTQDLLNQNHSANAVRPNSKI 120 130 140 150 160 170 310 320 330 340 350 360 pF1KE0 KVKFEQNGSSKNSHLVSPAVSNSHQNVLSNYFPRVSFANQKAFRGVNGSPRISVTVGNIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KVKFEQNGSSKNSHLVSPAVSNSHQNVLSNYFPRVSFANQKAFRGVNGSPRISVTVGNIP 180 190 200 210 220 230 370 380 390 400 410 420 pF1KE0 KNSVSSSSQRRVSSSKISLRNSSKVTESASVMPSQDVSGSEDTFPNKRPRLEDKTVFDNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KNSVSSSSQRRVSSSKISLRNSSKVTESASVMPSQDVSGSEDTFPNKRPRLEDKTVFDNF 240 250 260 270 280 290 430 440 450 460 470 480 pF1KE0 FIKKEQIKSSGNDPKYSTTTAQNSSSSSSQSKMVNCPVCQNEVLESQINEHLDWCLEGDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FIKKEQIKSSGNDPKYSTTTAQNSSSSSSQSKMVNCPVCQNEVLESQINEHLDWCLEGDS 300 310 320 330 340 350 pF1KE0 IKVKSEESL ::::::::: XP_011 IKVKSEESL 360 >>NP_001010984 (OMIM: 616086,616200) sprT-like domain-co (250 aa) initn: 1701 init1: 1701 opt: 1701 Z-score: 1713.3 bits: 325.5 E(85289): 1.1e-88 Smith-Waterman score: 1701; 100.0% identity (100.0% similar) in 239 aa overlap (1-239:1-239) 10 20 30 40 50 60 pF1KE0 MDDDLMLALRLQEEWNLQEAERDHAQESLSLVDASWELVDPTPDLQALFVQFNDQFFWGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDDDLMLALRLQEEWNLQEAERDHAQESLSLVDASWELVDPTPDLQALFVQFNDQFFWGQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 LEAVEVKWSVRMTLCAGICSYEGKGGMCSIRLSEPLLKLRPRKDLVETLLHEMIHAYLFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LEAVEVKWSVRMTLCAGICSYEGKGGMCSIRLSEPLLKLRPRKDLVETLLHEMIHAYLFV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 TNNDKDREGHGPEFCKHMHRINSLTGANITVYHTFHDEVDEYRRHWWRCNGPCQHRPPYY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TNNDKDREGHGPEFCKHMHRINSLTGANITVYHTFHDEVDEYRRHWWRCNGPCQHRPPYY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 GYVKRATNREPSAHDYWWAEHQKTCGGTYIKIKEPENYSKKGKGKAKLGKEPVLAAENKD ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GYVKRATNREPSAHDYWWAEHQKTCGGTYIKIKEPENYSKKGKGKAKLGKEPVLAAENKG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 KPNRGEAQLVIPFSGKGYVLGETSNLPSPGKLITSHAINKTQDLLNQNHSANAVRLNSKI NP_001 TFVYILLIFM 250 >>NP_001248391 (OMIM: 616086,616200) sprT-like domain-co (207 aa) initn: 734 init1: 734 opt: 740 Z-score: 753.3 bits: 147.6 E(85289): 3.2e-35 Smith-Waterman score: 1307; 82.0% identity (82.0% similar) in 239 aa overlap (1-239:1-196) 10 20 30 40 50 60 pF1KE0 MDDDLMLALRLQEEWNLQEAERDHAQESLSLVDASWELVDPTPDLQALFVQFNDQFFWGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDDDLMLALRLQEEWNLQEAERDHAQESLSLVDASWELVDPTPDLQALFVQFNDQFFWGQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 LEAVEVKWSVRMTLCAGICSYEGKGGMCSIRLSEPLLKLRPRKDLVETLLHEMIHAYLFV ::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LEAVEVKWSVRMTLCAGICSYEGKGGMCSIRLSEPLLKLRPRKDLVE------------- 70 80 90 100 130 140 150 160 170 180 pF1KE0 TNNDKDREGHGPEFCKHMHRINSLTGANITVYHTFHDEVDEYRRHWWRCNGPCQHRPPYY :::::::::::::::::::::::::::::: NP_001 ------------------------------VYHTFHDEVDEYRRHWWRCNGPCQHRPPYY 110 120 130 190 200 210 220 230 240 pF1KE0 GYVKRATNREPSAHDYWWAEHQKTCGGTYIKIKEPENYSKKGKGKAKLGKEPVLAAENKD ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GYVKRATNREPSAHDYWWAEHQKTCGGTYIKIKEPENYSKKGKGKAKLGKEPVLAAENKG 140 150 160 170 180 190 250 260 270 280 290 300 pF1KE0 KPNRGEAQLVIPFSGKGYVLGETSNLPSPGKLITSHAINKTQDLLNQNHSANAVRLNSKI NP_001 TFVYILLIFM 200 489 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 16:33:00 2016 done: Thu Nov 3 16:33:01 2016 Total Scan time: 8.820 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]