FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0308, 519 aa 1>>>pF1KE0308 519 - 519 aa - 519 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.0411+/-0.000772; mu= 15.9134+/- 0.046 mean_var=96.6652+/-18.884, 0's: 0 Z-trim(110.2): 12 B-trim: 0 in 0/51 Lambda= 0.130448 statistics sampled from 11451 (11458) to 11451 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.714), E-opt: 0.2 (0.352), width: 16 Scan time: 3.130 The best scores are: opt bits E(32554) CCDS3798.1 FAM198B gene_id:51313|Hs108|chr4 ( 519) 3548 678.0 7e-195 CCDS34087.1 FAM198B gene_id:51313|Hs108|chr4 ( 527) 3330 637.0 1.6e-182 CCDS46808.1 FAM198A gene_id:729085|Hs108|chr3 ( 575) 804 161.6 2.2e-39 >>CCDS3798.1 FAM198B gene_id:51313|Hs108|chr4 (519 aa) initn: 3548 init1: 3548 opt: 3548 Z-score: 3612.2 bits: 678.0 E(32554): 7e-195 Smith-Waterman score: 3548; 100.0% identity (100.0% similar) in 519 aa overlap (1-519:1-519) 10 20 30 40 50 60 pF1KE0 MTCPDKPGQLINWFICSLCVPRVRKLWSSRRPRTRRNLLLGTACAIYLGFLVSQVGRASL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS37 MTCPDKPGQLINWFICSLCVPRVRKLWSSRRPRTRRNLLLGTACAIYLGFLVSQVGRASL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 QHGQAAEKGPHRSRDTAEPSFPEIPLDGTLAPPESQGNGSTLQPNVVYITLRSKRSKPAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS37 QHGQAAEKGPHRSRDTAEPSFPEIPLDGTLAPPESQGNGSTLQPNVVYITLRSKRSKPAN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 IRGTVKPKRRKKHAVASAAPGQEALVGPSLQPQEAAREADAVAPGYAQGANLVKIGERPW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS37 IRGTVKPKRRKKHAVASAAPGQEALVGPSLQPQEAAREADAVAPGYAQGANLVKIGERPW 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 RLVRGPGVRAGGPDFLQPSSRESNIRIYSESAPSWLSKDDIRRMRLLADSAVAGLRPVSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS37 RLVRGPGVRAGGPDFLQPSSRESNIRIYSESAPSWLSKDDIRRMRLLADSAVAGLRPVSS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 RSGARLLVLEGGAPGAVLRCGPSPCGLLKQPLDMSEVFAFHLDRILGLNRTLPSVSRKAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS37 RSGARLLVLEGGAPGAVLRCGPSPCGLLKQPLDMSEVFAFHLDRILGLNRTLPSVSRKAE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 FIQDGRPCPIILWDASLSSASNDTHSSVKLTWGTYQQLLKQKCWQNGRVPKPESGCTEIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS37 FIQDGRPCPIILWDASLSSASNDTHSSVKLTWGTYQQLLKQKCWQNGRVPKPESGCTEIH 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 HHEWSKMALFDFLLQIYNRLDTNCCGFRPRKEDACVQNGLRPKCDDQGSAALAHIIQRKH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS37 HHEWSKMALFDFLLQIYNRLDTNCCGFRPRKEDACVQNGLRPKCDDQGSAALAHIIQRKH 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE0 DPRHLVFIDNKGFFDRSEDNLNFKLLEGIKEFPASAVSVLKSQHLRQKLLQSLFLDKVYW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS37 DPRHLVFIDNKGFFDRSEDNLNFKLLEGIKEFPASAVSVLKSQHLRQKLLQSLFLDKVYW 430 440 450 460 470 480 490 500 510 pF1KE0 ESQGGRQGIEKLIDVIEHRAKILITYINAHGVKVLPMNE ::::::::::::::::::::::::::::::::::::::: CCDS37 ESQGGRQGIEKLIDVIEHRAKILITYINAHGVKVLPMNE 490 500 510 >>CCDS34087.1 FAM198B gene_id:51313|Hs108|chr4 (527 aa) initn: 3357 init1: 2045 opt: 3330 Z-score: 3390.4 bits: 637.0 E(32554): 1.6e-182 Smith-Waterman score: 3331; 93.8% identity (95.1% similar) in 529 aa overlap (1-519:1-527) 10 20 30 40 50 60 pF1KE0 MTCPDKPGQLINWFICSLCVPRVRKLWSSRRPRTRRNLLLGTACAIYLGFLVSQVGRASL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 MTCPDKPGQLINWFICSLCVPRVRKLWSSRRPRTRRNLLLGTACAIYLGFLVSQVGRASL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 QHGQAAEKGPHRSRDTAEPSFPEIPLDGTLAPPESQGNGSTLQPNVVYITLRSKRSKPAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 QHGQAAEKGPHRSRDTAEPSFPEIPLDGTLAPPESQGNGSTLQPNVVYITLRSKRSKPAN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 IRGTVKPKRRKKHAVASAAPGQEALVGPSLQPQEAAREADAVAPGYAQGANLVKIGERPW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 IRGTVKPKRRKKHAVASAAPGQEALVGPSLQPQEAAREADAVAPGYAQGANLVKIGERPW 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 RLVRGPGVRAGGPDFLQPSSRESNIRIYSESAPSWLSKDDIRRMRLLADSAVAGLRPVSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 RLVRGPGVRAGGPDFLQPSSRESNIRIYSESAPSWLSKDDIRRMRLLADSAVAGLRPVSS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 RSGARLLVLEGGAPGAVLRCGPSPCGLLKQPLDMSEVFAFHLDRILGLNRTLPSVSRKAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 RSGARLLVLEGGAPGAVLRCGPSPCGLLKQPLDMSEVFAFHLDRILGLNRTLPSVSRKAE 250 260 270 280 290 300 310 320 330 340 350 pF1KE0 FIQDGRPCPIIL---------W-DASLSSASNDTHSSVKLTWGTYQQLLKQKCWQNGRVP ::: . . . : : . . :. .::::::::::::::::::::: CCDS34 FIQAAAAACLSMRLAFFIFPAWEDMRVPGKCCIGHA--RLTWGTYQQLLKQKCWQNGRVP 310 320 330 340 350 360 370 380 390 400 410 pF1KE0 KPESGCTEIHHHEWSKMALFDFLLQIYNRLDTNCCGFRPRKEDACVQNGLRPKCDDQGSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 KPESGCTEIHHHEWSKMALFDFLLQIYNRLDTNCCGFRPRKEDACVQNGLRPKCDDQGSA 360 370 380 390 400 410 420 430 440 450 460 470 pF1KE0 ALAHIIQRKHDPRHLVFIDNKGFFDRSEDNLNFKLLEGIKEFPASAVSVLKSQHLRQKLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 ALAHIIQRKHDPRHLVFIDNKGFFDRSEDNLNFKLLEGIKEFPASAVSVLKSQHLRQKLL 420 430 440 450 460 470 480 490 500 510 pF1KE0 QSLFLDKVYWESQGGRQGIEKLIDVIEHRAKILITYINAHGVKVLPMNE ::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 QSLFLDKVYWESQGGRQGIEKLIDVIEHRAKILITYINAHGVKVLPMNE 480 490 500 510 520 >>CCDS46808.1 FAM198A gene_id:729085|Hs108|chr3 (575 aa) initn: 806 init1: 575 opt: 804 Z-score: 820.7 bits: 161.6 E(32554): 2.2e-39 Smith-Waterman score: 857; 33.1% identity (57.7% similar) in 553 aa overlap (4-515:42-570) 10 20 30 pF1KE0 MTCPDKPGQLINWFICSLCVPRVRK-LWSSRRP :: :: . . . . ..:. : :::: CCDS46 KRRPVIAFCLLMILSAMAVTRFPPQRPSAGPD-PGPMEPQGVTGAPATHIRQALSSSRRQ 20 30 40 50 60 70 40 50 60 70 80 pF1KE0 RTR-----------RNLLLGTACAIYLGFLVSQVGRASLQHGQAAEKGPHR-SRDTAEPS :.: :: .: .:: : ..: :. . : . . : : :: . . CCDS46 RARNMGFWRSRALPRNSIL--VCAEEQGHR-ARVDRSRESPG-GDLRHPGRVRRDITLSG 80 90 100 110 120 90 100 110 120 130 pF1KE0 FPEIPLDGTLAPPESQGNGSTLQPNVVYITLRSK-RSKPANIRGTVKPKRRKKHAVASAA :.. . .. :.. :. .. . : . ... :.: . : : CCDS46 HPRLSTQHVVLLREDE-VGDPGTKDLGHPQHGSPIQETQSEVVTLVSPLPGSDMA---AL 130 140 150 160 170 180 140 150 160 170 180 190 pF1KE0 PGQEALVGPSLQPQEA------AREADAVAPGYAQGANLVKIGERPWRLVRGPGV--RAG :. .: : .: :. : . : :.. : . : . : :: . CCDS46 PAWRATSGLTLWPHTAEGRDLLGAENRALTGGQQAEDPTLASGAHQW-----PGSVEKLQ 190 200 210 220 230 200 210 220 230 240 250 pF1KE0 GPDFLQPSSRESNIRIYSESAPSWLSKDDIRRMRLLADSAVAGLRPVSSRSGARLLVLEG : . . . :. : .. :: ::. :.. .::::.. :. ..: :. ::. CCDS46 GSVWCDAETLLSSSRTGGQ-APPWLTDHDVQMLRLLAQGEVVD----KARVPAHGQVLQV 240 250 260 270 280 290 260 270 280 290 300 pF1KE0 G-----------APGAVLRCGPSPCGLLKQPLDMSEVFAFHLDRILGLNRTLPSVSRKAE : .: :. . :::.:.: :. ::..::.::.::: :.::.:.:. . CCDS46 GFSTEAALQDLSSPRLSQLCSQGLCGLIKRPGDLPEVLSFHVDRVLGLRRSLPAVARRFH 300 310 320 330 340 350 310 320 330 340 350 pF1KE0 F------IQDGRPCPIILW--DASLSSASNDTHSSVKLTWGTYQQLLKQKCWQNGRVPKP :: :.: : :.. : .. ..:. : : :: :: ..: :..: CCDS46 SPLLPYRYTDGGARPVIWWAPDVQHLSDPDEDQNSLALGWLQYQALLAHSCNWPGQAP-- 360 370 380 390 400 410 360 370 380 390 400 410 pF1KE0 ESGCTEIHHHEWSKMALFDFLLQIYNRLDTNCCGFRPRKEDACVQNGLRPKCDDQGSAAL : ::: ::...::::::::...::: ::::.:. : ::.. :: ::.. . : CCDS46 ---CPGIHHTEWARLALFDFLLQVHDRLDRYCCGFEPEPSDPCVEERLREKCQNPAELRL 420 430 440 450 460 420 430 440 450 460 470 pF1KE0 AHIIQRKHDPRHLVFIDNKGFFDRSEDNLNFKLLEGIKEFPASAVSVLKSQHLRQKLLQS .::. :. :: :::.::: : ... ::.:::.::::: :: :::.:: : :.. ::.: CCDS46 VHILVRSSDPSHLVYIDNAGNLQHPEDKLNFRLLEGIDGFPESAVKVLASGCLQNMLLKS 470 480 490 500 510 520 480 490 500 510 pF1KE0 LFLDKVYWESQGGRQGIEKLIDVIEHRAKILITYINAHGVKVLPMNE : .: :.:::::: ::........:.:...:. .:. :.. .. CCDS46 LQMDPVFWESQGGAQGLKQVLQTLEQRGQVLLGHIQKHNLTLFRDEDP 530 540 550 560 570 519 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 16:24:47 2016 done: Thu Nov 3 16:24:47 2016 Total Scan time: 3.130 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]