Result of FASTA (omim) for
pF1KE0311
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0311, 1265 aa
1>>>pF1KE0311 1265 - 1265 aa - 1265 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.5127+/-0.000576; mu= 7.4671+/- 0.036
mean_var=160.3473+/-31.969, 0's: 0 Z-trim(109.8): 92 B-trim: 106 in 1/53
Lambda= 0.101285
statistics sampled from 18004 (18090) to 18004 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.536), E-opt: 0.2 (0.212), width: 16
Scan time: 11.590
The best scores are: opt bits E(85289)
NP_689737 (OMIM: 612425) shugoshin 2 isoform 1 [Ho (1265) 8145 1203.9 0
XP_005246402 (OMIM: 612425) PREDICTED: shugoshin-l (1265) 8145 1203.9 0
XP_011509036 (OMIM: 612425) PREDICTED: shugoshin-l (1265) 8145 1203.9 0
XP_005246401 (OMIM: 612425) PREDICTED: shugoshin-l (1280) 8145 1203.9 0
XP_016858942 (OMIM: 612425) PREDICTED: shugoshin-l (1295) 8145 1203.9 0
XP_016858941 (OMIM: 612425) PREDICTED: shugoshin-l (1295) 8145 1203.9 0
NP_001153518 (OMIM: 612425) shugoshin 2 isoform 3 (1261) 8112 1199.1 0
XP_016858943 (OMIM: 612425) PREDICTED: shugoshin-l (1291) 8112 1199.1 0
NP_001153505 (OMIM: 612425) shugoshin 2 isoform 2 (1260) 7782 1150.8 0
NP_001242982 (OMIM: 188000,610855) ankyrin repeat (1709) 222 46.2 0.0023
NP_055730 (OMIM: 188000,610855) ankyrin repeat dom (1710) 222 46.2 0.0023
XP_016871421 (OMIM: 188000,610855) PREDICTED: anky (2031) 222 46.2 0.0026
XP_006717488 (OMIM: 188000,610855) PREDICTED: anky (2031) 222 46.2 0.0026
XP_016871419 (OMIM: 188000,610855) PREDICTED: anky (2062) 222 46.2 0.0027
XP_011517718 (OMIM: 188000,610855) PREDICTED: anky (2062) 222 46.2 0.0027
XP_016871420 (OMIM: 188000,610855) PREDICTED: anky (2062) 222 46.2 0.0027
XP_006717486 (OMIM: 188000,610855) PREDICTED: anky (2072) 222 46.2 0.0027
XP_016871418 (OMIM: 188000,610855) PREDICTED: anky (2108) 222 46.2 0.0027
XP_016871417 (OMIM: 188000,610855) PREDICTED: anky (2112) 222 46.2 0.0027
>>NP_689737 (OMIM: 612425) shugoshin 2 isoform 1 [Homo s (1265 aa)
initn: 8145 init1: 8145 opt: 8145 Z-score: 6440.4 bits: 1203.9 E(85289): 0
Smith-Waterman score: 8145; 99.7% identity (99.9% similar) in 1265 aa overlap (1-1265:1-1265)
10 20 30 40 50 60
pF1KE0 MECPVMETGSLFTSGIKRHLKDKRISKTTKLNVSLASKIKTKILNNSSIFKISLKHNNRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 MECPVMETGSLFTSGIKRHLKDKRISKTTKLNVSLASKIKTKILNNSSIFKISLKHNNRA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 LAQALSREKENSRRITTEKMLLQKEVEKLNFENTFLRLKLNNLNKKLIDIEALMNNNLIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 LAQALSREKENSRRITTEKMLLQKEVEKLNFENTFLRLKLNNLNKKLIDIEALMNNNLIT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 ATEMSSLSEFHQSSFLLSASKKKRVSKQCKLMRLPFARVPLTSNDDEDEDKEKMQCDNNI
: ::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::
NP_689 AIEMSSLSEFHQSSFLLSASKKKRISKQCKLMRLPFARVPLTSNDDEDEDKEKMQCDNNI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 KSKTLPDIPSSGSTTQPLSTQDNSEVLFLKENNQNVYGLDDSEHISSIVDVPPRESHSHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 KSKTLPDIPSSGSTTQPLSTQDNSEVLFLKENNQNVYGLDDSEHISSIVDVPPRESHSHS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 DQSSKTSLMSEMRNAQSIGRRWEKPSPSNVTERKKRGSSWESNNLSADTPCATVLDKQHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 DQSSKTSLMSEMRNAQSIGRRWEKPSPSNVTERKKRGSSWESNNLSADTPCATVLDKQHI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 SSPELNCNNEINAHTNETNTEMQRNKQDLPGLSSESAREPNAECMNQIEDNDDFQLQKTV
::::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::
NP_689 SSPELNCNNEINGHTNETNTEMQRNKQDLPGLSSESAREPNAECMNQIEDNDDFQLQKTV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 YDADMDLTASEVSKIVAVSTGIKKKSNKKTNEHGMKTFRKVKDSSSEKKRERSKRQFKNS
::::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::
NP_689 YDADMDLTASEVSKIVTVSTGIKKKSNKKTNEHGMKTFRKVKDSSSEKKRERSKRQFKNS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE0 SDVDIGEKIENRTERSDVLDGKRGAEDPGFIFNNEQLAQMNEQLAQVNELKKMTLQTGFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 SDVDIGEKIENRTERSDVLDGKRGAEDPGFIFNNEQLAQMNEQLAQVNELKKMTLQTGFE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE0 QGDRENVLCNKKEKRITNEQEETYSLSQSSGKFHQESKFDKGQNSLTCNKSKASRQTFVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 QGDRENVLCNKKEKRITNEQEETYSLSQSSGKFHQESKFDKGQNSLTCNKSKASRQTFVI
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE0 HKLEKDNLLPNQKDKVTIYENLDVTNEFHTANLSTKDNGNLCDYGTHNILDLKKYVTDIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 HKLEKDNLLPNQKDKVTIYENLDVTNEFHTANLSTKDNGNLCDYGTHNILDLKKYVTDIQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE0 PSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGNFFFKTQEDKEPISEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 PSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGNFFFKTQEDKEPISEN
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE0 IEVSKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNESKVNKKLRQKVNRKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 IEVSKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNESKVNKKLRQKVNRKT
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE0 EIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEFETPALSTKDSGNLYDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 EIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEFETPALSTKDSGNLYDS
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE0 EIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIPETNQIYENDNKGVHDLEKDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 EIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIPETNQIYENDNKGVHDLEKDN
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE0 FFSLTPKDKETISENLQVTNEFQTVDLLIKDNGNLCDYDTQNILELKKYVTDRKSAEQNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 FFSLTPKDKETISENLQVTNEFQTVDLLIKDNGNLCDYDTQNILELKKYVTDRKSAEQNE
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE0 SKINKLRNKVNWKTEIISEMNQIYEDNDKDAHVQESYTKDLDFKVNKSKQKLECQDIINK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 SKINKLRNKVNWKTEIISEMNQIYEDNDKDAHVQESYTKDLDFKVNKSKQKLECQDIINK
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE0 HYMEVNSNEKESCDQILDSYKVVKKRKKESSCKAKNILTKAKNKLASQLTESSQTSISLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 HYMEVNSNEKESCDQILDSYKVVKKRKKESSCKAKNILTKAKNKLASQLTESSQTSISLE
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE0 SDLKHITSEADSDPGNPVELCKTQKQSTTTLNKKDLPFVEEIKEGECQVKKVNKMTSKSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 SDLKHITSEADSDPGNPVELCKTQKQSTTTLNKKDLPFVEEIKEGECQVKKVNKMTSKSK
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE0 KRKTSIDPSPESHEVMERILDSVQGKSTVSEQADKENNLENEKMVKNKPDFYTKAFRSLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 KRKTSIDPSPESHEVMERILDSVQGKSTVSEQADKENNLENEKMVKNKPDFYTKAFRSLS
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE0 EIHSPNIQDSSFDSVREGLVPLSVSSGKNVIIKENFALECSPAFQVSDDEHEKMNKMKFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 EIHSPNIQDSSFDSVREGLVPLSVSSGKNVIIKENFALECSPAFQVSDDEHEKMNKMKFK
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE0 VNRRTQKSGIGDRPLQDLSNTSFVSNNTAESENKSEDLSSERTSRRRRCTPFYFKEPSLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 VNRRTQKSGIGDRPLQDLSNTSFVSNNTAESENKSEDLSSERTSRRRRCTPFYFKEPSLR
1210 1220 1230 1240 1250 1260
pF1KE0 DKMRR
:::::
NP_689 DKMRR
>>XP_005246402 (OMIM: 612425) PREDICTED: shugoshin-like (1265 aa)
initn: 8145 init1: 8145 opt: 8145 Z-score: 6440.4 bits: 1203.9 E(85289): 0
Smith-Waterman score: 8145; 99.7% identity (99.9% similar) in 1265 aa overlap (1-1265:1-1265)
10 20 30 40 50 60
pF1KE0 MECPVMETGSLFTSGIKRHLKDKRISKTTKLNVSLASKIKTKILNNSSIFKISLKHNNRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MECPVMETGSLFTSGIKRHLKDKRISKTTKLNVSLASKIKTKILNNSSIFKISLKHNNRA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 LAQALSREKENSRRITTEKMLLQKEVEKLNFENTFLRLKLNNLNKKLIDIEALMNNNLIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LAQALSREKENSRRITTEKMLLQKEVEKLNFENTFLRLKLNNLNKKLIDIEALMNNNLIT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 ATEMSSLSEFHQSSFLLSASKKKRVSKQCKLMRLPFARVPLTSNDDEDEDKEKMQCDNNI
: ::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::
XP_005 AIEMSSLSEFHQSSFLLSASKKKRISKQCKLMRLPFARVPLTSNDDEDEDKEKMQCDNNI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 KSKTLPDIPSSGSTTQPLSTQDNSEVLFLKENNQNVYGLDDSEHISSIVDVPPRESHSHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KSKTLPDIPSSGSTTQPLSTQDNSEVLFLKENNQNVYGLDDSEHISSIVDVPPRESHSHS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 DQSSKTSLMSEMRNAQSIGRRWEKPSPSNVTERKKRGSSWESNNLSADTPCATVLDKQHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DQSSKTSLMSEMRNAQSIGRRWEKPSPSNVTERKKRGSSWESNNLSADTPCATVLDKQHI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 SSPELNCNNEINAHTNETNTEMQRNKQDLPGLSSESAREPNAECMNQIEDNDDFQLQKTV
::::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSPELNCNNEINGHTNETNTEMQRNKQDLPGLSSESAREPNAECMNQIEDNDDFQLQKTV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 YDADMDLTASEVSKIVAVSTGIKKKSNKKTNEHGMKTFRKVKDSSSEKKRERSKRQFKNS
::::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::
XP_005 YDADMDLTASEVSKIVTVSTGIKKKSNKKTNEHGMKTFRKVKDSSSEKKRERSKRQFKNS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE0 SDVDIGEKIENRTERSDVLDGKRGAEDPGFIFNNEQLAQMNEQLAQVNELKKMTLQTGFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SDVDIGEKIENRTERSDVLDGKRGAEDPGFIFNNEQLAQMNEQLAQVNELKKMTLQTGFE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE0 QGDRENVLCNKKEKRITNEQEETYSLSQSSGKFHQESKFDKGQNSLTCNKSKASRQTFVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QGDRENVLCNKKEKRITNEQEETYSLSQSSGKFHQESKFDKGQNSLTCNKSKASRQTFVI
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE0 HKLEKDNLLPNQKDKVTIYENLDVTNEFHTANLSTKDNGNLCDYGTHNILDLKKYVTDIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HKLEKDNLLPNQKDKVTIYENLDVTNEFHTANLSTKDNGNLCDYGTHNILDLKKYVTDIQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE0 PSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGNFFFKTQEDKEPISEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGNFFFKTQEDKEPISEN
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE0 IEVSKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNESKVNKKLRQKVNRKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IEVSKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNESKVNKKLRQKVNRKT
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE0 EIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEFETPALSTKDSGNLYDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEFETPALSTKDSGNLYDS
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE0 EIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIPETNQIYENDNKGVHDLEKDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIPETNQIYENDNKGVHDLEKDN
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE0 FFSLTPKDKETISENLQVTNEFQTVDLLIKDNGNLCDYDTQNILELKKYVTDRKSAEQNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FFSLTPKDKETISENLQVTNEFQTVDLLIKDNGNLCDYDTQNILELKKYVTDRKSAEQNE
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE0 SKINKLRNKVNWKTEIISEMNQIYEDNDKDAHVQESYTKDLDFKVNKSKQKLECQDIINK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SKINKLRNKVNWKTEIISEMNQIYEDNDKDAHVQESYTKDLDFKVNKSKQKLECQDIINK
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE0 HYMEVNSNEKESCDQILDSYKVVKKRKKESSCKAKNILTKAKNKLASQLTESSQTSISLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HYMEVNSNEKESCDQILDSYKVVKKRKKESSCKAKNILTKAKNKLASQLTESSQTSISLE
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE0 SDLKHITSEADSDPGNPVELCKTQKQSTTTLNKKDLPFVEEIKEGECQVKKVNKMTSKSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SDLKHITSEADSDPGNPVELCKTQKQSTTTLNKKDLPFVEEIKEGECQVKKVNKMTSKSK
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE0 KRKTSIDPSPESHEVMERILDSVQGKSTVSEQADKENNLENEKMVKNKPDFYTKAFRSLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KRKTSIDPSPESHEVMERILDSVQGKSTVSEQADKENNLENEKMVKNKPDFYTKAFRSLS
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE0 EIHSPNIQDSSFDSVREGLVPLSVSSGKNVIIKENFALECSPAFQVSDDEHEKMNKMKFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EIHSPNIQDSSFDSVREGLVPLSVSSGKNVIIKENFALECSPAFQVSDDEHEKMNKMKFK
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE0 VNRRTQKSGIGDRPLQDLSNTSFVSNNTAESENKSEDLSSERTSRRRRCTPFYFKEPSLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VNRRTQKSGIGDRPLQDLSNTSFVSNNTAESENKSEDLSSERTSRRRRCTPFYFKEPSLR
1210 1220 1230 1240 1250 1260
pF1KE0 DKMRR
:::::
XP_005 DKMRR
>>XP_011509036 (OMIM: 612425) PREDICTED: shugoshin-like (1265 aa)
initn: 8145 init1: 8145 opt: 8145 Z-score: 6440.4 bits: 1203.9 E(85289): 0
Smith-Waterman score: 8145; 99.7% identity (99.9% similar) in 1265 aa overlap (1-1265:1-1265)
10 20 30 40 50 60
pF1KE0 MECPVMETGSLFTSGIKRHLKDKRISKTTKLNVSLASKIKTKILNNSSIFKISLKHNNRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MECPVMETGSLFTSGIKRHLKDKRISKTTKLNVSLASKIKTKILNNSSIFKISLKHNNRA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 LAQALSREKENSRRITTEKMLLQKEVEKLNFENTFLRLKLNNLNKKLIDIEALMNNNLIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LAQALSREKENSRRITTEKMLLQKEVEKLNFENTFLRLKLNNLNKKLIDIEALMNNNLIT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 ATEMSSLSEFHQSSFLLSASKKKRVSKQCKLMRLPFARVPLTSNDDEDEDKEKMQCDNNI
: ::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::
XP_011 AIEMSSLSEFHQSSFLLSASKKKRISKQCKLMRLPFARVPLTSNDDEDEDKEKMQCDNNI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 KSKTLPDIPSSGSTTQPLSTQDNSEVLFLKENNQNVYGLDDSEHISSIVDVPPRESHSHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KSKTLPDIPSSGSTTQPLSTQDNSEVLFLKENNQNVYGLDDSEHISSIVDVPPRESHSHS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 DQSSKTSLMSEMRNAQSIGRRWEKPSPSNVTERKKRGSSWESNNLSADTPCATVLDKQHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DQSSKTSLMSEMRNAQSIGRRWEKPSPSNVTERKKRGSSWESNNLSADTPCATVLDKQHI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 SSPELNCNNEINAHTNETNTEMQRNKQDLPGLSSESAREPNAECMNQIEDNDDFQLQKTV
::::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSPELNCNNEINGHTNETNTEMQRNKQDLPGLSSESAREPNAECMNQIEDNDDFQLQKTV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 YDADMDLTASEVSKIVAVSTGIKKKSNKKTNEHGMKTFRKVKDSSSEKKRERSKRQFKNS
::::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::
XP_011 YDADMDLTASEVSKIVTVSTGIKKKSNKKTNEHGMKTFRKVKDSSSEKKRERSKRQFKNS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE0 SDVDIGEKIENRTERSDVLDGKRGAEDPGFIFNNEQLAQMNEQLAQVNELKKMTLQTGFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SDVDIGEKIENRTERSDVLDGKRGAEDPGFIFNNEQLAQMNEQLAQVNELKKMTLQTGFE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE0 QGDRENVLCNKKEKRITNEQEETYSLSQSSGKFHQESKFDKGQNSLTCNKSKASRQTFVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QGDRENVLCNKKEKRITNEQEETYSLSQSSGKFHQESKFDKGQNSLTCNKSKASRQTFVI
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE0 HKLEKDNLLPNQKDKVTIYENLDVTNEFHTANLSTKDNGNLCDYGTHNILDLKKYVTDIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HKLEKDNLLPNQKDKVTIYENLDVTNEFHTANLSTKDNGNLCDYGTHNILDLKKYVTDIQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE0 PSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGNFFFKTQEDKEPISEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGNFFFKTQEDKEPISEN
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE0 IEVSKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNESKVNKKLRQKVNRKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IEVSKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNESKVNKKLRQKVNRKT
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE0 EIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEFETPALSTKDSGNLYDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEFETPALSTKDSGNLYDS
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE0 EIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIPETNQIYENDNKGVHDLEKDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIPETNQIYENDNKGVHDLEKDN
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE0 FFSLTPKDKETISENLQVTNEFQTVDLLIKDNGNLCDYDTQNILELKKYVTDRKSAEQNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FFSLTPKDKETISENLQVTNEFQTVDLLIKDNGNLCDYDTQNILELKKYVTDRKSAEQNE
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE0 SKINKLRNKVNWKTEIISEMNQIYEDNDKDAHVQESYTKDLDFKVNKSKQKLECQDIINK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SKINKLRNKVNWKTEIISEMNQIYEDNDKDAHVQESYTKDLDFKVNKSKQKLECQDIINK
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE0 HYMEVNSNEKESCDQILDSYKVVKKRKKESSCKAKNILTKAKNKLASQLTESSQTSISLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HYMEVNSNEKESCDQILDSYKVVKKRKKESSCKAKNILTKAKNKLASQLTESSQTSISLE
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE0 SDLKHITSEADSDPGNPVELCKTQKQSTTTLNKKDLPFVEEIKEGECQVKKVNKMTSKSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SDLKHITSEADSDPGNPVELCKTQKQSTTTLNKKDLPFVEEIKEGECQVKKVNKMTSKSK
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE0 KRKTSIDPSPESHEVMERILDSVQGKSTVSEQADKENNLENEKMVKNKPDFYTKAFRSLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KRKTSIDPSPESHEVMERILDSVQGKSTVSEQADKENNLENEKMVKNKPDFYTKAFRSLS
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE0 EIHSPNIQDSSFDSVREGLVPLSVSSGKNVIIKENFALECSPAFQVSDDEHEKMNKMKFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EIHSPNIQDSSFDSVREGLVPLSVSSGKNVIIKENFALECSPAFQVSDDEHEKMNKMKFK
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE0 VNRRTQKSGIGDRPLQDLSNTSFVSNNTAESENKSEDLSSERTSRRRRCTPFYFKEPSLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VNRRTQKSGIGDRPLQDLSNTSFVSNNTAESENKSEDLSSERTSRRRRCTPFYFKEPSLR
1210 1220 1230 1240 1250 1260
pF1KE0 DKMRR
:::::
XP_011 DKMRR
>>XP_005246401 (OMIM: 612425) PREDICTED: shugoshin-like (1280 aa)
initn: 8145 init1: 8145 opt: 8145 Z-score: 6440.3 bits: 1203.9 E(85289): 0
Smith-Waterman score: 8145; 99.7% identity (99.9% similar) in 1265 aa overlap (1-1265:16-1280)
10 20 30 40
pF1KE0 MECPVMETGSLFTSGIKRHLKDKRISKTTKLNVSLASKIKTKILN
:::::::::::::::::::::::::::::::::::::::::::::
XP_005 MEARRLGKEMEAWGVMECPVMETGSLFTSGIKRHLKDKRISKTTKLNVSLASKIKTKILN
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE0 NSSIFKISLKHNNRALAQALSREKENSRRITTEKMLLQKEVEKLNFENTFLRLKLNNLNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NSSIFKISLKHNNRALAQALSREKENSRRITTEKMLLQKEVEKLNFENTFLRLKLNNLNK
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE0 KLIDIEALMNNNLITATEMSSLSEFHQSSFLLSASKKKRVSKQCKLMRLPFARVPLTSND
:::::::::::::::: ::::::::::::::::::::::.::::::::::::::::::::
XP_005 KLIDIEALMNNNLITAIEMSSLSEFHQSSFLLSASKKKRISKQCKLMRLPFARVPLTSND
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE0 DEDEDKEKMQCDNNIKSKTLPDIPSSGSTTQPLSTQDNSEVLFLKENNQNVYGLDDSEHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DEDEDKEKMQCDNNIKSKTLPDIPSSGSTTQPLSTQDNSEVLFLKENNQNVYGLDDSEHI
190 200 210 220 230 240
230 240 250 260 270 280
pF1KE0 SSIVDVPPRESHSHSDQSSKTSLMSEMRNAQSIGRRWEKPSPSNVTERKKRGSSWESNNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSIVDVPPRESHSHSDQSSKTSLMSEMRNAQSIGRRWEKPSPSNVTERKKRGSSWESNNL
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE0 SADTPCATVLDKQHISSPELNCNNEINAHTNETNTEMQRNKQDLPGLSSESAREPNAECM
:::::::::::::::::::::::::::.::::::::::::::::::::::::::::::::
XP_005 SADTPCATVLDKQHISSPELNCNNEINGHTNETNTEMQRNKQDLPGLSSESAREPNAECM
310 320 330 340 350 360
350 360 370 380 390 400
pF1KE0 NQIEDNDDFQLQKTVYDADMDLTASEVSKIVAVSTGIKKKSNKKTNEHGMKTFRKVKDSS
:::::::::::::::::::::::::::::::.::::::::::::::::::::::::::::
XP_005 NQIEDNDDFQLQKTVYDADMDLTASEVSKIVTVSTGIKKKSNKKTNEHGMKTFRKVKDSS
370 380 390 400 410 420
410 420 430 440 450 460
pF1KE0 SEKKRERSKRQFKNSSDVDIGEKIENRTERSDVLDGKRGAEDPGFIFNNEQLAQMNEQLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SEKKRERSKRQFKNSSDVDIGEKIENRTERSDVLDGKRGAEDPGFIFNNEQLAQMNEQLA
430 440 450 460 470 480
470 480 490 500 510 520
pF1KE0 QVNELKKMTLQTGFEQGDRENVLCNKKEKRITNEQEETYSLSQSSGKFHQESKFDKGQNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QVNELKKMTLQTGFEQGDRENVLCNKKEKRITNEQEETYSLSQSSGKFHQESKFDKGQNS
490 500 510 520 530 540
530 540 550 560 570 580
pF1KE0 LTCNKSKASRQTFVIHKLEKDNLLPNQKDKVTIYENLDVTNEFHTANLSTKDNGNLCDYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LTCNKSKASRQTFVIHKLEKDNLLPNQKDKVTIYENLDVTNEFHTANLSTKDNGNLCDYG
550 560 570 580 590 600
590 600 610 620 630 640
pF1KE0 THNILDLKKYVTDIQPSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 THNILDLKKYVTDIQPSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGN
610 620 630 640 650 660
650 660 670 680 690 700
pF1KE0 FFFKTQEDKEPISENIEVSKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FFFKTQEDKEPISENIEVSKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNE
670 680 690 700 710 720
710 720 730 740 750 760
pF1KE0 SKVNKKLRQKVNRKTEIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SKVNKKLRQKVNRKTEIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEFE
730 740 750 760 770 780
770 780 790 800 810 820
pF1KE0 TPALSTKDSGNLYDSEIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIPETNQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TPALSTKDSGNLYDSEIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIPETNQI
790 800 810 820 830 840
830 840 850 860 870 880
pF1KE0 YENDNKGVHDLEKDNFFSLTPKDKETISENLQVTNEFQTVDLLIKDNGNLCDYDTQNILE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YENDNKGVHDLEKDNFFSLTPKDKETISENLQVTNEFQTVDLLIKDNGNLCDYDTQNILE
850 860 870 880 890 900
890 900 910 920 930 940
pF1KE0 LKKYVTDRKSAEQNESKINKLRNKVNWKTEIISEMNQIYEDNDKDAHVQESYTKDLDFKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LKKYVTDRKSAEQNESKINKLRNKVNWKTEIISEMNQIYEDNDKDAHVQESYTKDLDFKV
910 920 930 940 950 960
950 960 970 980 990 1000
pF1KE0 NKSKQKLECQDIINKHYMEVNSNEKESCDQILDSYKVVKKRKKESSCKAKNILTKAKNKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NKSKQKLECQDIINKHYMEVNSNEKESCDQILDSYKVVKKRKKESSCKAKNILTKAKNKL
970 980 990 1000 1010 1020
1010 1020 1030 1040 1050 1060
pF1KE0 ASQLTESSQTSISLESDLKHITSEADSDPGNPVELCKTQKQSTTTLNKKDLPFVEEIKEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ASQLTESSQTSISLESDLKHITSEADSDPGNPVELCKTQKQSTTTLNKKDLPFVEEIKEG
1030 1040 1050 1060 1070 1080
1070 1080 1090 1100 1110 1120
pF1KE0 ECQVKKVNKMTSKSKKRKTSIDPSPESHEVMERILDSVQGKSTVSEQADKENNLENEKMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ECQVKKVNKMTSKSKKRKTSIDPSPESHEVMERILDSVQGKSTVSEQADKENNLENEKMV
1090 1100 1110 1120 1130 1140
1130 1140 1150 1160 1170 1180
pF1KE0 KNKPDFYTKAFRSLSEIHSPNIQDSSFDSVREGLVPLSVSSGKNVIIKENFALECSPAFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KNKPDFYTKAFRSLSEIHSPNIQDSSFDSVREGLVPLSVSSGKNVIIKENFALECSPAFQ
1150 1160 1170 1180 1190 1200
1190 1200 1210 1220 1230 1240
pF1KE0 VSDDEHEKMNKMKFKVNRRTQKSGIGDRPLQDLSNTSFVSNNTAESENKSEDLSSERTSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VSDDEHEKMNKMKFKVNRRTQKSGIGDRPLQDLSNTSFVSNNTAESENKSEDLSSERTSR
1210 1220 1230 1240 1250 1260
1250 1260
pF1KE0 RRRCTPFYFKEPSLRDKMRR
::::::::::::::::::::
XP_005 RRRCTPFYFKEPSLRDKMRR
1270 1280
>>XP_016858942 (OMIM: 612425) PREDICTED: shugoshin-like (1295 aa)
initn: 8145 init1: 8145 opt: 8145 Z-score: 6440.2 bits: 1203.9 E(85289): 0
Smith-Waterman score: 8145; 99.7% identity (99.9% similar) in 1265 aa overlap (1-1265:31-1295)
10 20 30
pF1KE0 MECPVMETGSLFTSGIKRHLKDKRISKTTK
::::::::::::::::::::::::::::::
XP_016 MWLHHSCLCCLLSLQMEARRLGKEMEAWGVMECPVMETGSLFTSGIKRHLKDKRISKTTK
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE0 LNVSLASKIKTKILNNSSIFKISLKHNNRALAQALSREKENSRRITTEKMLLQKEVEKLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LNVSLASKIKTKILNNSSIFKISLKHNNRALAQALSREKENSRRITTEKMLLQKEVEKLN
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE0 FENTFLRLKLNNLNKKLIDIEALMNNNLITATEMSSLSEFHQSSFLLSASKKKRVSKQCK
::::::::::::::::::::::::::::::: ::::::::::::::::::::::.:::::
XP_016 FENTFLRLKLNNLNKKLIDIEALMNNNLITAIEMSSLSEFHQSSFLLSASKKKRISKQCK
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE0 LMRLPFARVPLTSNDDEDEDKEKMQCDNNIKSKTLPDIPSSGSTTQPLSTQDNSEVLFLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LMRLPFARVPLTSNDDEDEDKEKMQCDNNIKSKTLPDIPSSGSTTQPLSTQDNSEVLFLK
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE0 ENNQNVYGLDDSEHISSIVDVPPRESHSHSDQSSKTSLMSEMRNAQSIGRRWEKPSPSNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ENNQNVYGLDDSEHISSIVDVPPRESHSHSDQSSKTSLMSEMRNAQSIGRRWEKPSPSNV
250 260 270 280 290 300
280 290 300 310 320 330
pF1KE0 TERKKRGSSWESNNLSADTPCATVLDKQHISSPELNCNNEINAHTNETNTEMQRNKQDLP
::::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::
XP_016 TERKKRGSSWESNNLSADTPCATVLDKQHISSPELNCNNEINGHTNETNTEMQRNKQDLP
310 320 330 340 350 360
340 350 360 370 380 390
pF1KE0 GLSSESAREPNAECMNQIEDNDDFQLQKTVYDADMDLTASEVSKIVAVSTGIKKKSNKKT
::::::::::::::::::::::::::::::::::::::::::::::.:::::::::::::
XP_016 GLSSESAREPNAECMNQIEDNDDFQLQKTVYDADMDLTASEVSKIVTVSTGIKKKSNKKT
370 380 390 400 410 420
400 410 420 430 440 450
pF1KE0 NEHGMKTFRKVKDSSSEKKRERSKRQFKNSSDVDIGEKIENRTERSDVLDGKRGAEDPGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NEHGMKTFRKVKDSSSEKKRERSKRQFKNSSDVDIGEKIENRTERSDVLDGKRGAEDPGF
430 440 450 460 470 480
460 470 480 490 500 510
pF1KE0 IFNNEQLAQMNEQLAQVNELKKMTLQTGFEQGDRENVLCNKKEKRITNEQEETYSLSQSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IFNNEQLAQMNEQLAQVNELKKMTLQTGFEQGDRENVLCNKKEKRITNEQEETYSLSQSS
490 500 510 520 530 540
520 530 540 550 560 570
pF1KE0 GKFHQESKFDKGQNSLTCNKSKASRQTFVIHKLEKDNLLPNQKDKVTIYENLDVTNEFHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GKFHQESKFDKGQNSLTCNKSKASRQTFVIHKLEKDNLLPNQKDKVTIYENLDVTNEFHT
550 560 570 580 590 600
580 590 600 610 620 630
pF1KE0 ANLSTKDNGNLCDYGTHNILDLKKYVTDIQPSEQNESNINKLRKKVNRKTEIISGMNHMY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ANLSTKDNGNLCDYGTHNILDLKKYVTDIQPSEQNESNINKLRKKVNRKTEIISGMNHMY
610 620 630 640 650 660
640 650 660 670 680 690
pF1KE0 EDNDKDVVHGLKKGNFFFKTQEDKEPISENIEVSKELQIPALSTRDNENQCDYRTQNVLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDNDKDVVHGLKKGNFFFKTQEDKEPISENIEVSKELQIPALSTRDNENQCDYRTQNVLG
670 680 690 700 710 720
700 710 720 730 740 750
pF1KE0 LQKQITNMYPVQQNESKVNKKLRQKVNRKTEIISEVNHLDNDKSIEYTVKSHSLFLTQKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQKQITNMYPVQQNESKVNKKLRQKVNRKTEIISEVNHLDNDKSIEYTVKSHSLFLTQKD
730 740 750 760 770 780
760 770 780 790 800 810
pF1KE0 KEIIPGNLEDPSEFETPALSTKDSGNLYDSEIQNVLGVKHGHDMQPACQNDSKIGKKPRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KEIIPGNLEDPSEFETPALSTKDSGNLYDSEIQNVLGVKHGHDMQPACQNDSKIGKKPRL
790 800 810 820 830 840
820 830 840 850 860 870
pF1KE0 NVCQKSEIIPETNQIYENDNKGVHDLEKDNFFSLTPKDKETISENLQVTNEFQTVDLLIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NVCQKSEIIPETNQIYENDNKGVHDLEKDNFFSLTPKDKETISENLQVTNEFQTVDLLIK
850 860 870 880 890 900
880 890 900 910 920 930
pF1KE0 DNGNLCDYDTQNILELKKYVTDRKSAEQNESKINKLRNKVNWKTEIISEMNQIYEDNDKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DNGNLCDYDTQNILELKKYVTDRKSAEQNESKINKLRNKVNWKTEIISEMNQIYEDNDKD
910 920 930 940 950 960
940 950 960 970 980 990
pF1KE0 AHVQESYTKDLDFKVNKSKQKLECQDIINKHYMEVNSNEKESCDQILDSYKVVKKRKKES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AHVQESYTKDLDFKVNKSKQKLECQDIINKHYMEVNSNEKESCDQILDSYKVVKKRKKES
970 980 990 1000 1010 1020
1000 1010 1020 1030 1040 1050
pF1KE0 SCKAKNILTKAKNKLASQLTESSQTSISLESDLKHITSEADSDPGNPVELCKTQKQSTTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SCKAKNILTKAKNKLASQLTESSQTSISLESDLKHITSEADSDPGNPVELCKTQKQSTTT
1030 1040 1050 1060 1070 1080
1060 1070 1080 1090 1100 1110
pF1KE0 LNKKDLPFVEEIKEGECQVKKVNKMTSKSKKRKTSIDPSPESHEVMERILDSVQGKSTVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LNKKDLPFVEEIKEGECQVKKVNKMTSKSKKRKTSIDPSPESHEVMERILDSVQGKSTVS
1090 1100 1110 1120 1130 1140
1120 1130 1140 1150 1160 1170
pF1KE0 EQADKENNLENEKMVKNKPDFYTKAFRSLSEIHSPNIQDSSFDSVREGLVPLSVSSGKNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EQADKENNLENEKMVKNKPDFYTKAFRSLSEIHSPNIQDSSFDSVREGLVPLSVSSGKNV
1150 1160 1170 1180 1190 1200
1180 1190 1200 1210 1220 1230
pF1KE0 IIKENFALECSPAFQVSDDEHEKMNKMKFKVNRRTQKSGIGDRPLQDLSNTSFVSNNTAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IIKENFALECSPAFQVSDDEHEKMNKMKFKVNRRTQKSGIGDRPLQDLSNTSFVSNNTAE
1210 1220 1230 1240 1250 1260
1240 1250 1260
pF1KE0 SENKSEDLSSERTSRRRRCTPFYFKEPSLRDKMRR
:::::::::::::::::::::::::::::::::::
XP_016 SENKSEDLSSERTSRRRRCTPFYFKEPSLRDKMRR
1270 1280 1290
>>XP_016858941 (OMIM: 612425) PREDICTED: shugoshin-like (1295 aa)
initn: 8145 init1: 8145 opt: 8145 Z-score: 6440.2 bits: 1203.9 E(85289): 0
Smith-Waterman score: 8145; 99.7% identity (99.9% similar) in 1265 aa overlap (1-1265:31-1295)
10 20 30
pF1KE0 MECPVMETGSLFTSGIKRHLKDKRISKTTK
::::::::::::::::::::::::::::::
XP_016 MWLHHSCLCCLLSLQMEARRLGKEMEAWGVMECPVMETGSLFTSGIKRHLKDKRISKTTK
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE0 LNVSLASKIKTKILNNSSIFKISLKHNNRALAQALSREKENSRRITTEKMLLQKEVEKLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LNVSLASKIKTKILNNSSIFKISLKHNNRALAQALSREKENSRRITTEKMLLQKEVEKLN
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE0 FENTFLRLKLNNLNKKLIDIEALMNNNLITATEMSSLSEFHQSSFLLSASKKKRVSKQCK
::::::::::::::::::::::::::::::: ::::::::::::::::::::::.:::::
XP_016 FENTFLRLKLNNLNKKLIDIEALMNNNLITAIEMSSLSEFHQSSFLLSASKKKRISKQCK
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE0 LMRLPFARVPLTSNDDEDEDKEKMQCDNNIKSKTLPDIPSSGSTTQPLSTQDNSEVLFLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LMRLPFARVPLTSNDDEDEDKEKMQCDNNIKSKTLPDIPSSGSTTQPLSTQDNSEVLFLK
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE0 ENNQNVYGLDDSEHISSIVDVPPRESHSHSDQSSKTSLMSEMRNAQSIGRRWEKPSPSNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ENNQNVYGLDDSEHISSIVDVPPRESHSHSDQSSKTSLMSEMRNAQSIGRRWEKPSPSNV
250 260 270 280 290 300
280 290 300 310 320 330
pF1KE0 TERKKRGSSWESNNLSADTPCATVLDKQHISSPELNCNNEINAHTNETNTEMQRNKQDLP
::::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::
XP_016 TERKKRGSSWESNNLSADTPCATVLDKQHISSPELNCNNEINGHTNETNTEMQRNKQDLP
310 320 330 340 350 360
340 350 360 370 380 390
pF1KE0 GLSSESAREPNAECMNQIEDNDDFQLQKTVYDADMDLTASEVSKIVAVSTGIKKKSNKKT
::::::::::::::::::::::::::::::::::::::::::::::.:::::::::::::
XP_016 GLSSESAREPNAECMNQIEDNDDFQLQKTVYDADMDLTASEVSKIVTVSTGIKKKSNKKT
370 380 390 400 410 420
400 410 420 430 440 450
pF1KE0 NEHGMKTFRKVKDSSSEKKRERSKRQFKNSSDVDIGEKIENRTERSDVLDGKRGAEDPGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NEHGMKTFRKVKDSSSEKKRERSKRQFKNSSDVDIGEKIENRTERSDVLDGKRGAEDPGF
430 440 450 460 470 480
460 470 480 490 500 510
pF1KE0 IFNNEQLAQMNEQLAQVNELKKMTLQTGFEQGDRENVLCNKKEKRITNEQEETYSLSQSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IFNNEQLAQMNEQLAQVNELKKMTLQTGFEQGDRENVLCNKKEKRITNEQEETYSLSQSS
490 500 510 520 530 540
520 530 540 550 560 570
pF1KE0 GKFHQESKFDKGQNSLTCNKSKASRQTFVIHKLEKDNLLPNQKDKVTIYENLDVTNEFHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GKFHQESKFDKGQNSLTCNKSKASRQTFVIHKLEKDNLLPNQKDKVTIYENLDVTNEFHT
550 560 570 580 590 600
580 590 600 610 620 630
pF1KE0 ANLSTKDNGNLCDYGTHNILDLKKYVTDIQPSEQNESNINKLRKKVNRKTEIISGMNHMY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ANLSTKDNGNLCDYGTHNILDLKKYVTDIQPSEQNESNINKLRKKVNRKTEIISGMNHMY
610 620 630 640 650 660
640 650 660 670 680 690
pF1KE0 EDNDKDVVHGLKKGNFFFKTQEDKEPISENIEVSKELQIPALSTRDNENQCDYRTQNVLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDNDKDVVHGLKKGNFFFKTQEDKEPISENIEVSKELQIPALSTRDNENQCDYRTQNVLG
670 680 690 700 710 720
700 710 720 730 740 750
pF1KE0 LQKQITNMYPVQQNESKVNKKLRQKVNRKTEIISEVNHLDNDKSIEYTVKSHSLFLTQKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQKQITNMYPVQQNESKVNKKLRQKVNRKTEIISEVNHLDNDKSIEYTVKSHSLFLTQKD
730 740 750 760 770 780
760 770 780 790 800 810
pF1KE0 KEIIPGNLEDPSEFETPALSTKDSGNLYDSEIQNVLGVKHGHDMQPACQNDSKIGKKPRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KEIIPGNLEDPSEFETPALSTKDSGNLYDSEIQNVLGVKHGHDMQPACQNDSKIGKKPRL
790 800 810 820 830 840
820 830 840 850 860 870
pF1KE0 NVCQKSEIIPETNQIYENDNKGVHDLEKDNFFSLTPKDKETISENLQVTNEFQTVDLLIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NVCQKSEIIPETNQIYENDNKGVHDLEKDNFFSLTPKDKETISENLQVTNEFQTVDLLIK
850 860 870 880 890 900
880 890 900 910 920 930
pF1KE0 DNGNLCDYDTQNILELKKYVTDRKSAEQNESKINKLRNKVNWKTEIISEMNQIYEDNDKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DNGNLCDYDTQNILELKKYVTDRKSAEQNESKINKLRNKVNWKTEIISEMNQIYEDNDKD
910 920 930 940 950 960
940 950 960 970 980 990
pF1KE0 AHVQESYTKDLDFKVNKSKQKLECQDIINKHYMEVNSNEKESCDQILDSYKVVKKRKKES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AHVQESYTKDLDFKVNKSKQKLECQDIINKHYMEVNSNEKESCDQILDSYKVVKKRKKES
970 980 990 1000 1010 1020
1000 1010 1020 1030 1040 1050
pF1KE0 SCKAKNILTKAKNKLASQLTESSQTSISLESDLKHITSEADSDPGNPVELCKTQKQSTTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SCKAKNILTKAKNKLASQLTESSQTSISLESDLKHITSEADSDPGNPVELCKTQKQSTTT
1030 1040 1050 1060 1070 1080
1060 1070 1080 1090 1100 1110
pF1KE0 LNKKDLPFVEEIKEGECQVKKVNKMTSKSKKRKTSIDPSPESHEVMERILDSVQGKSTVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LNKKDLPFVEEIKEGECQVKKVNKMTSKSKKRKTSIDPSPESHEVMERILDSVQGKSTVS
1090 1100 1110 1120 1130 1140
1120 1130 1140 1150 1160 1170
pF1KE0 EQADKENNLENEKMVKNKPDFYTKAFRSLSEIHSPNIQDSSFDSVREGLVPLSVSSGKNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EQADKENNLENEKMVKNKPDFYTKAFRSLSEIHSPNIQDSSFDSVREGLVPLSVSSGKNV
1150 1160 1170 1180 1190 1200
1180 1190 1200 1210 1220 1230
pF1KE0 IIKENFALECSPAFQVSDDEHEKMNKMKFKVNRRTQKSGIGDRPLQDLSNTSFVSNNTAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IIKENFALECSPAFQVSDDEHEKMNKMKFKVNRRTQKSGIGDRPLQDLSNTSFVSNNTAE
1210 1220 1230 1240 1250 1260
1240 1250 1260
pF1KE0 SENKSEDLSSERTSRRRRCTPFYFKEPSLRDKMRR
:::::::::::::::::::::::::::::::::::
XP_016 SENKSEDLSSERTSRRRRCTPFYFKEPSLRDKMRR
1270 1280 1290
>>NP_001153518 (OMIM: 612425) shugoshin 2 isoform 3 [Hom (1261 aa)
initn: 8676 init1: 8112 opt: 8112 Z-score: 6414.3 bits: 1199.1 E(85289): 0
Smith-Waterman score: 8112; 99.6% identity (99.9% similar) in 1261 aa overlap (1-1261:1-1261)
10 20 30 40 50 60
pF1KE0 MECPVMETGSLFTSGIKRHLKDKRISKTTKLNVSLASKIKTKILNNSSIFKISLKHNNRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MECPVMETGSLFTSGIKRHLKDKRISKTTKLNVSLASKIKTKILNNSSIFKISLKHNNRA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 LAQALSREKENSRRITTEKMLLQKEVEKLNFENTFLRLKLNNLNKKLIDIEALMNNNLIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LAQALSREKENSRRITTEKMLLQKEVEKLNFENTFLRLKLNNLNKKLIDIEALMNNNLIT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 ATEMSSLSEFHQSSFLLSASKKKRVSKQCKLMRLPFARVPLTSNDDEDEDKEKMQCDNNI
: ::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::
NP_001 AIEMSSLSEFHQSSFLLSASKKKRISKQCKLMRLPFARVPLTSNDDEDEDKEKMQCDNNI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 KSKTLPDIPSSGSTTQPLSTQDNSEVLFLKENNQNVYGLDDSEHISSIVDVPPRESHSHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KSKTLPDIPSSGSTTQPLSTQDNSEVLFLKENNQNVYGLDDSEHISSIVDVPPRESHSHS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 DQSSKTSLMSEMRNAQSIGRRWEKPSPSNVTERKKRGSSWESNNLSADTPCATVLDKQHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DQSSKTSLMSEMRNAQSIGRRWEKPSPSNVTERKKRGSSWESNNLSADTPCATVLDKQHI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 SSPELNCNNEINAHTNETNTEMQRNKQDLPGLSSESAREPNAECMNQIEDNDDFQLQKTV
::::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSPELNCNNEINGHTNETNTEMQRNKQDLPGLSSESAREPNAECMNQIEDNDDFQLQKTV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 YDADMDLTASEVSKIVAVSTGIKKKSNKKTNEHGMKTFRKVKDSSSEKKRERSKRQFKNS
::::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::
NP_001 YDADMDLTASEVSKIVTVSTGIKKKSNKKTNEHGMKTFRKVKDSSSEKKRERSKRQFKNS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE0 SDVDIGEKIENRTERSDVLDGKRGAEDPGFIFNNEQLAQMNEQLAQVNELKKMTLQTGFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SDVDIGEKIENRTERSDVLDGKRGAEDPGFIFNNEQLAQMNEQLAQVNELKKMTLQTGFE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE0 QGDRENVLCNKKEKRITNEQEETYSLSQSSGKFHQESKFDKGQNSLTCNKSKASRQTFVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QGDRENVLCNKKEKRITNEQEETYSLSQSSGKFHQESKFDKGQNSLTCNKSKASRQTFVI
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE0 HKLEKDNLLPNQKDKVTIYENLDVTNEFHTANLSTKDNGNLCDYGTHNILDLKKYVTDIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HKLEKDNLLPNQKDKVTIYENLDVTNEFHTANLSTKDNGNLCDYGTHNILDLKKYVTDIQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE0 PSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGNFFFKTQEDKEPISEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGNFFFKTQEDKEPISEN
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE0 IEVSKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNESKVNKKLRQKVNRKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IEVSKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNESKVNKKLRQKVNRKT
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE0 EIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEFETPALSTKDSGNLYDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEFETPALSTKDSGNLYDS
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE0 EIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIPETNQIYENDNKGVHDLEKDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIPETNQIYENDNKGVHDLEKDN
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE0 FFSLTPKDKETISENLQVTNEFQTVDLLIKDNGNLCDYDTQNILELKKYVTDRKSAEQNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FFSLTPKDKETISENLQVTNEFQTVDLLIKDNGNLCDYDTQNILELKKYVTDRKSAEQNE
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE0 SKINKLRNKVNWKTEIISEMNQIYEDNDKDAHVQESYTKDLDFKVNKSKQKLECQDIINK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SKINKLRNKVNWKTEIISEMNQIYEDNDKDAHVQESYTKDLDFKVNKSKQKLECQDIINK
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE0 HYMEVNSNEKESCDQILDSYKVVKKRKKESSCKAKNILTKAKNKLASQLTESSQTSISLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HYMEVNSNEKESCDQILDSYKVVKKRKKESSCKAKNILTKAKNKLASQLTESSQTSISLE
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE0 SDLKHITSEADSDPGNPVELCKTQKQSTTTLNKKDLPFVEEIKEGECQVKKVNKMTSKSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SDLKHITSEADSDPGNPVELCKTQKQSTTTLNKKDLPFVEEIKEGECQVKKVNKMTSKSK
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE0 KRKTSIDPSPESHEVMERILDSVQGKSTVSEQADKENNLENEKMVKNKPDFYTKAFRSLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KRKTSIDPSPESHEVMERILDSVQGKSTVSEQADKENNLENEKMVKNKPDFYTKAFRSLS
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE0 EIHSPNIQDSSFDSVREGLVPLSVSSGKNVIIKENFALECSPAFQVSDDEHEKMNKMKFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EIHSPNIQDSSFDSVREGLVPLSVSSGKNVIIKENFALECSPAFQVSDDEHEKMNKMKFK
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE0 VNRRTQKSGIGDRPLQDLSNTSFVSNNTAESENKSEDLSSERTSRRRRCTPFYFKEPSLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VNRRTQKSGIGDRPLQDLSNTSFVSNNTAESENKSEDLSSERTSRRRRCTPFYFKEPSLR
1210 1220 1230 1240 1250 1260
pF1KE0 DKMRR
.
NP_001 E
>>XP_016858943 (OMIM: 612425) PREDICTED: shugoshin-like (1291 aa)
initn: 8676 init1: 8112 opt: 8112 Z-score: 6414.2 bits: 1199.1 E(85289): 0
Smith-Waterman score: 8112; 99.6% identity (99.9% similar) in 1261 aa overlap (1-1261:31-1291)
10 20 30
pF1KE0 MECPVMETGSLFTSGIKRHLKDKRISKTTK
::::::::::::::::::::::::::::::
XP_016 MWLHHSCLCCLLSLQMEARRLGKEMEAWGVMECPVMETGSLFTSGIKRHLKDKRISKTTK
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE0 LNVSLASKIKTKILNNSSIFKISLKHNNRALAQALSREKENSRRITTEKMLLQKEVEKLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LNVSLASKIKTKILNNSSIFKISLKHNNRALAQALSREKENSRRITTEKMLLQKEVEKLN
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE0 FENTFLRLKLNNLNKKLIDIEALMNNNLITATEMSSLSEFHQSSFLLSASKKKRVSKQCK
::::::::::::::::::::::::::::::: ::::::::::::::::::::::.:::::
XP_016 FENTFLRLKLNNLNKKLIDIEALMNNNLITAIEMSSLSEFHQSSFLLSASKKKRISKQCK
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE0 LMRLPFARVPLTSNDDEDEDKEKMQCDNNIKSKTLPDIPSSGSTTQPLSTQDNSEVLFLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LMRLPFARVPLTSNDDEDEDKEKMQCDNNIKSKTLPDIPSSGSTTQPLSTQDNSEVLFLK
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE0 ENNQNVYGLDDSEHISSIVDVPPRESHSHSDQSSKTSLMSEMRNAQSIGRRWEKPSPSNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ENNQNVYGLDDSEHISSIVDVPPRESHSHSDQSSKTSLMSEMRNAQSIGRRWEKPSPSNV
250 260 270 280 290 300
280 290 300 310 320 330
pF1KE0 TERKKRGSSWESNNLSADTPCATVLDKQHISSPELNCNNEINAHTNETNTEMQRNKQDLP
::::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::
XP_016 TERKKRGSSWESNNLSADTPCATVLDKQHISSPELNCNNEINGHTNETNTEMQRNKQDLP
310 320 330 340 350 360
340 350 360 370 380 390
pF1KE0 GLSSESAREPNAECMNQIEDNDDFQLQKTVYDADMDLTASEVSKIVAVSTGIKKKSNKKT
::::::::::::::::::::::::::::::::::::::::::::::.:::::::::::::
XP_016 GLSSESAREPNAECMNQIEDNDDFQLQKTVYDADMDLTASEVSKIVTVSTGIKKKSNKKT
370 380 390 400 410 420
400 410 420 430 440 450
pF1KE0 NEHGMKTFRKVKDSSSEKKRERSKRQFKNSSDVDIGEKIENRTERSDVLDGKRGAEDPGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NEHGMKTFRKVKDSSSEKKRERSKRQFKNSSDVDIGEKIENRTERSDVLDGKRGAEDPGF
430 440 450 460 470 480
460 470 480 490 500 510
pF1KE0 IFNNEQLAQMNEQLAQVNELKKMTLQTGFEQGDRENVLCNKKEKRITNEQEETYSLSQSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IFNNEQLAQMNEQLAQVNELKKMTLQTGFEQGDRENVLCNKKEKRITNEQEETYSLSQSS
490 500 510 520 530 540
520 530 540 550 560 570
pF1KE0 GKFHQESKFDKGQNSLTCNKSKASRQTFVIHKLEKDNLLPNQKDKVTIYENLDVTNEFHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GKFHQESKFDKGQNSLTCNKSKASRQTFVIHKLEKDNLLPNQKDKVTIYENLDVTNEFHT
550 560 570 580 590 600
580 590 600 610 620 630
pF1KE0 ANLSTKDNGNLCDYGTHNILDLKKYVTDIQPSEQNESNINKLRKKVNRKTEIISGMNHMY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ANLSTKDNGNLCDYGTHNILDLKKYVTDIQPSEQNESNINKLRKKVNRKTEIISGMNHMY
610 620 630 640 650 660
640 650 660 670 680 690
pF1KE0 EDNDKDVVHGLKKGNFFFKTQEDKEPISENIEVSKELQIPALSTRDNENQCDYRTQNVLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDNDKDVVHGLKKGNFFFKTQEDKEPISENIEVSKELQIPALSTRDNENQCDYRTQNVLG
670 680 690 700 710 720
700 710 720 730 740 750
pF1KE0 LQKQITNMYPVQQNESKVNKKLRQKVNRKTEIISEVNHLDNDKSIEYTVKSHSLFLTQKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQKQITNMYPVQQNESKVNKKLRQKVNRKTEIISEVNHLDNDKSIEYTVKSHSLFLTQKD
730 740 750 760 770 780
760 770 780 790 800 810
pF1KE0 KEIIPGNLEDPSEFETPALSTKDSGNLYDSEIQNVLGVKHGHDMQPACQNDSKIGKKPRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KEIIPGNLEDPSEFETPALSTKDSGNLYDSEIQNVLGVKHGHDMQPACQNDSKIGKKPRL
790 800 810 820 830 840
820 830 840 850 860 870
pF1KE0 NVCQKSEIIPETNQIYENDNKGVHDLEKDNFFSLTPKDKETISENLQVTNEFQTVDLLIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NVCQKSEIIPETNQIYENDNKGVHDLEKDNFFSLTPKDKETISENLQVTNEFQTVDLLIK
850 860 870 880 890 900
880 890 900 910 920 930
pF1KE0 DNGNLCDYDTQNILELKKYVTDRKSAEQNESKINKLRNKVNWKTEIISEMNQIYEDNDKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DNGNLCDYDTQNILELKKYVTDRKSAEQNESKINKLRNKVNWKTEIISEMNQIYEDNDKD
910 920 930 940 950 960
940 950 960 970 980 990
pF1KE0 AHVQESYTKDLDFKVNKSKQKLECQDIINKHYMEVNSNEKESCDQILDSYKVVKKRKKES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AHVQESYTKDLDFKVNKSKQKLECQDIINKHYMEVNSNEKESCDQILDSYKVVKKRKKES
970 980 990 1000 1010 1020
1000 1010 1020 1030 1040 1050
pF1KE0 SCKAKNILTKAKNKLASQLTESSQTSISLESDLKHITSEADSDPGNPVELCKTQKQSTTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SCKAKNILTKAKNKLASQLTESSQTSISLESDLKHITSEADSDPGNPVELCKTQKQSTTT
1030 1040 1050 1060 1070 1080
1060 1070 1080 1090 1100 1110
pF1KE0 LNKKDLPFVEEIKEGECQVKKVNKMTSKSKKRKTSIDPSPESHEVMERILDSVQGKSTVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LNKKDLPFVEEIKEGECQVKKVNKMTSKSKKRKTSIDPSPESHEVMERILDSVQGKSTVS
1090 1100 1110 1120 1130 1140
1120 1130 1140 1150 1160 1170
pF1KE0 EQADKENNLENEKMVKNKPDFYTKAFRSLSEIHSPNIQDSSFDSVREGLVPLSVSSGKNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EQADKENNLENEKMVKNKPDFYTKAFRSLSEIHSPNIQDSSFDSVREGLVPLSVSSGKNV
1150 1160 1170 1180 1190 1200
1180 1190 1200 1210 1220 1230
pF1KE0 IIKENFALECSPAFQVSDDEHEKMNKMKFKVNRRTQKSGIGDRPLQDLSNTSFVSNNTAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IIKENFALECSPAFQVSDDEHEKMNKMKFKVNRRTQKSGIGDRPLQDLSNTSFVSNNTAE
1210 1220 1230 1240 1250 1260
1240 1250 1260
pF1KE0 SENKSEDLSSERTSRRRRCTPFYFKEPSLRDKMRR
::::::::::::::::::::::::::::::.
XP_016 SENKSEDLSSERTSRRRRCTPFYFKEPSLRE
1270 1280 1290
>>NP_001153505 (OMIM: 612425) shugoshin 2 isoform 2 [Hom (1260 aa)
initn: 7782 init1: 7782 opt: 7782 Z-score: 6153.7 bits: 1150.8 E(85289): 0
Smith-Waterman score: 7782; 99.7% identity (99.9% similar) in 1210 aa overlap (1-1210:1-1210)
10 20 30 40 50 60
pF1KE0 MECPVMETGSLFTSGIKRHLKDKRISKTTKLNVSLASKIKTKILNNSSIFKISLKHNNRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MECPVMETGSLFTSGIKRHLKDKRISKTTKLNVSLASKIKTKILNNSSIFKISLKHNNRA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 LAQALSREKENSRRITTEKMLLQKEVEKLNFENTFLRLKLNNLNKKLIDIEALMNNNLIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LAQALSREKENSRRITTEKMLLQKEVEKLNFENTFLRLKLNNLNKKLIDIEALMNNNLIT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 ATEMSSLSEFHQSSFLLSASKKKRVSKQCKLMRLPFARVPLTSNDDEDEDKEKMQCDNNI
: ::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::
NP_001 AIEMSSLSEFHQSSFLLSASKKKRISKQCKLMRLPFARVPLTSNDDEDEDKEKMQCDNNI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 KSKTLPDIPSSGSTTQPLSTQDNSEVLFLKENNQNVYGLDDSEHISSIVDVPPRESHSHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KSKTLPDIPSSGSTTQPLSTQDNSEVLFLKENNQNVYGLDDSEHISSIVDVPPRESHSHS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 DQSSKTSLMSEMRNAQSIGRRWEKPSPSNVTERKKRGSSWESNNLSADTPCATVLDKQHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DQSSKTSLMSEMRNAQSIGRRWEKPSPSNVTERKKRGSSWESNNLSADTPCATVLDKQHI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 SSPELNCNNEINAHTNETNTEMQRNKQDLPGLSSESAREPNAECMNQIEDNDDFQLQKTV
::::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSPELNCNNEINGHTNETNTEMQRNKQDLPGLSSESAREPNAECMNQIEDNDDFQLQKTV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 YDADMDLTASEVSKIVAVSTGIKKKSNKKTNEHGMKTFRKVKDSSSEKKRERSKRQFKNS
::::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::
NP_001 YDADMDLTASEVSKIVTVSTGIKKKSNKKTNEHGMKTFRKVKDSSSEKKRERSKRQFKNS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE0 SDVDIGEKIENRTERSDVLDGKRGAEDPGFIFNNEQLAQMNEQLAQVNELKKMTLQTGFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SDVDIGEKIENRTERSDVLDGKRGAEDPGFIFNNEQLAQMNEQLAQVNELKKMTLQTGFE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE0 QGDRENVLCNKKEKRITNEQEETYSLSQSSGKFHQESKFDKGQNSLTCNKSKASRQTFVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QGDRENVLCNKKEKRITNEQEETYSLSQSSGKFHQESKFDKGQNSLTCNKSKASRQTFVI
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE0 HKLEKDNLLPNQKDKVTIYENLDVTNEFHTANLSTKDNGNLCDYGTHNILDLKKYVTDIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HKLEKDNLLPNQKDKVTIYENLDVTNEFHTANLSTKDNGNLCDYGTHNILDLKKYVTDIQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE0 PSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGNFFFKTQEDKEPISEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGNFFFKTQEDKEPISEN
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE0 IEVSKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNESKVNKKLRQKVNRKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IEVSKELQIPALSTRDNENQCDYRTQNVLGLQKQITNMYPVQQNESKVNKKLRQKVNRKT
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE0 EIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEFETPALSTKDSGNLYDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEFETPALSTKDSGNLYDS
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE0 EIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIPETNQIYENDNKGVHDLEKDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EIQNVLGVKHGHDMQPACQNDSKIGKKPRLNVCQKSEIIPETNQIYENDNKGVHDLEKDN
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE0 FFSLTPKDKETISENLQVTNEFQTVDLLIKDNGNLCDYDTQNILELKKYVTDRKSAEQNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FFSLTPKDKETISENLQVTNEFQTVDLLIKDNGNLCDYDTQNILELKKYVTDRKSAEQNE
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE0 SKINKLRNKVNWKTEIISEMNQIYEDNDKDAHVQESYTKDLDFKVNKSKQKLECQDIINK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SKINKLRNKVNWKTEIISEMNQIYEDNDKDAHVQESYTKDLDFKVNKSKQKLECQDIINK
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE0 HYMEVNSNEKESCDQILDSYKVVKKRKKESSCKAKNILTKAKNKLASQLTESSQTSISLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HYMEVNSNEKESCDQILDSYKVVKKRKKESSCKAKNILTKAKNKLASQLTESSQTSISLE
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE0 SDLKHITSEADSDPGNPVELCKTQKQSTTTLNKKDLPFVEEIKEGECQVKKVNKMTSKSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SDLKHITSEADSDPGNPVELCKTQKQSTTTLNKKDLPFVEEIKEGECQVKKVNKMTSKSK
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE0 KRKTSIDPSPESHEVMERILDSVQGKSTVSEQADKENNLENEKMVKNKPDFYTKAFRSLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KRKTSIDPSPESHEVMERILDSVQGKSTVSEQADKENNLENEKMVKNKPDFYTKAFRSLS
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE0 EIHSPNIQDSSFDSVREGLVPLSVSSGKNVIIKENFALECSPAFQVSDDEHEKMNKMKFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EIHSPNIQDSSFDSVREGLVPLSVSSGKNVIIKENFALECSPAFQVSDDEHEKMNKMKFK
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE0 VNRRTQKSGIGDRPLQDLSNTSFVSNNTAESENKSEDLSSERTSRRRRCTPFYFKEPSLR
::::::::::
NP_001 VNRRTQKSGIDHYRTCQIPVLFQITLLNLKISQKIYLQNGQAEEEGVLLSILKSQASETR
1210 1220 1230 1240 1250 1260
>>NP_001242982 (OMIM: 188000,610855) ankyrin repeat doma (1709 aa)
initn: 57 init1: 57 opt: 222 Z-score: 181.5 bits: 46.2 E(85289): 0.0023
Smith-Waterman score: 259; 19.6% identity (56.2% similar) in 904 aa overlap (63-927:813-1658)
40 50 60 70 80 90
pF1KE0 VSLASKIKTKILNNSSIFKISLKHNNRALAQALSREKENSRRITTEKMLLQKEVEKLNFE
. : :..:. :. . :. :. .. :..:
NP_001 WERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEME
790 800 810 820 830 840
100 110 120 130
pF1KE0 NTFLRLKLNNLNKKLIDIE--------ALMNNNLITATEMSSLSEFHQSSFLL------S
.. .::.. .. : . : : .. : ....:. .:..... . :
NP_001 LRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHS
850 860 870 880 890 900
140 150 160 170 180 190
pF1KE0 ASKKKRVSKQCKLMRLPFA--RVPLTSNDDEDEDKEKMQCDNNIKSKTLPDIPSSGSTTQ
..: .:.. .... .: :. . . .....::: .: ...: . .. :
NP_001 HEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEK-KCFEDLKI-----VKEKNEDLQ
910 920 930 940 950
200 210 220 230 240 250
pF1KE0 PLSTQDNSEVLFLKENNQNVYGLDDSEHISSIVDVPPRESHSHSDQSSKTSLMSEMRNAQ
. ..: :.: .:.. . . . .. .:. .....:: : .:... .
NP_001 K-TIKQNEETL-----TQTISQYNGRLSVLT-AENAMLNSKLENEKQSKERLEAEVESYH
960 970 980 990 1000
260 270 280 290 300 310
pF1KE0 SIGRRWEKPSPSNVTERKKRGSSWESNNLSADTPCATVLDKQHISSPELNCNNEINAHTN
: : . .: .:: : : :. . ::.... .:. :::: .. .
NP_001 S--RLAAAIHDRDQSETSKR--ELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQ-Q
1010 1020 1030 1040 1050 1060
320 330 340 350 360 370
pF1KE0 ETNTEMQRNKQDLPGLSSESAREPNAECMNQIE-DNDDFQLQKTVYDADMDLTASEVSKI
.:: . :. .. ...: . .. ..... : .. : : .. .. .:.:
NP_001 LFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKY
1070 1080 1090 1100 1110 1120
380 390 400 410 420 430
pF1KE0 VAVSTGIKKKSNKKTNEHGMKTFRKVKDSSSEKKRERSKRQFKNSSDVD-IGEKIENRTE
.. . ..... .. .:. . .:. :.. .: .. : .. ... : .:.. ..:
NP_001 IGKQESVEERLSQLQSENML--LRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESE
1130 1140 1150 1160 1170 1180
440 450 460 470 480
pF1KE0 RSDVLDGKRGAEDPGFI--FNNEQLAQMNEQLAQ---VNELKKMTLQTGFEQGDRENVLC
....: .:. : . ....: ::. . : .:.. .: .:. : :
NP_001 KQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLE
1190 1200 1210 1220 1230 1240
490 500 510 520 530 540
pF1KE0 NKKEKRITNEQEETYSLSQSSGKFH---QESKFDKGQNSLTCNKSKASRQTFVIHKLEKD
.. :: : ..:: .:... :... ::.. :. ... : .. ... .:::::
NP_001 VTSRYRI-NLEDETQDLKKKLGQIRNQLQEAQ-DRHTEAVRCAEKMQDHK----QKLEKD
1250 1260 1270 1280 1290
550 560 570 580 590 600
pF1KE0 NLLPNQKDKVTIYENLDVTNEFHTANLSTKDNGNLCDYGTHNILDLKKYVTDIQPSEQN-
: : :::. ...: .:.. : :.:: . : :. . .. .:.
NP_001 N----AKLKVTVKKQMDKIEELQKNLL----NANLSE-------DEKEQLKKLMELKQSL
1300 1310 1320 1330 1340
610 620 630 640 650 660
pF1KE0 ESNINK-LRKKVNRKTEIISGMNHMYEDNDKDVVHGLKKGNFFFKTQEDKEPISENIEVS
: :... ..:.:. . :: .:.... . . : . . ..:.: :. . . .:...
NP_001 ECNLDQEMKKNVELEREI-TGFKNLLKMTRKKL-NEYENGEFSFHGDLKTSQFEMDIQIN
1350 1360 1370 1380 1390
670 680 690 700 710 720
pF1KE0 K-ELQIPALSTRDNE--NQCDY-RTQNVLGLQKQITNMYPVQQNESKVNKKLRQKVNRKT
: . .: :... . ..: . :.: . ::... .: ::.. :..:. ..:...
NP_001 KLKHKIDDLTAELETAGSKCLHLDTKNQI-LQEELLSMKTVQKKCEKLQKN-KKKLEQ--
1400 1410 1420 1430 1440 1450
730 740 750 760 770 780
pF1KE0 EIISEVNHLDNDKSIEYTVKSHSLFLTQKDKEIIPGNLEDPSEFETPALSTKDSGNLYDS
:.:. .:.. . ::... . .. .. : .:.. . : .... :: .
NP_001 EVINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEVNLFLQAQAASQE--NLEQF
1460 1470 1480 1490 1500 1510
790 800 810 820 830
pF1KE0 EIQNVLGVKHGHDMQPACQNDSKIGK-KPRLNVCQKSEIIPETNQIYENDNKGVHDLE--
. .: ..: ... . .:...: : . .:.:. . .:.: .. : ..:
NP_001 RENNFASMKSQMELRIK-DLESELSKIKTSQEDFNKTEL-EKYKQLYLEELKVRKSLSSK
1520 1530 1540 1550 1560 1570
840 850 860 870 880 890
pF1KE0 --KDNFFSLTPKDKETISENLQVTNEFQTVDL--LIKDNGNLCDYDTQNILELKKYVTDR
: : :. . . . :. : . : :. ... : . .: :.:.. . :
NP_001 LTKTNE-RLAEVNTKLLVEKQQSRSLFTTLTTRPVMEPP---CVGNLNNSLDLNRKLIPR
1580 1590 1600 1610 1620
900 910 920 930 940 950
pF1KE0 KSAEQNESKINKLRNKVNWKTEIISEMNQIYEDNDKDAHVQESYTKDLDFKVNKSKQKLE
.. . :. : . : . .:.:.: : :
NP_001 ENLVISTSNP---RASNNSMENYLSKMQQELEKNITRELKEAAAELESGSIASPLGSTDE
1630 1640 1650 1660 1670 1680
960 970 980 990 1000 1010
pF1KE0 CQDIINKHYMEVNSNEKESCDQILDSYKVVKKRKKESSCKAKNILTKAKNKLASQLTESS
NP_001 SNLNQDLVWKASREYVQVLKKNYMI
1690 1700
1265 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 16:18:05 2016 done: Thu Nov 3 16:18:06 2016
Total Scan time: 11.590 Total Display time: 0.630
Function used was FASTA [36.3.4 Apr, 2011]