FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0314, 716 aa 1>>>pF1KE0314 716 - 716 aa - 716 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.6296+/-0.00103; mu= 6.0070+/- 0.062 mean_var=194.8743+/-38.841, 0's: 0 Z-trim(110.3): 25 B-trim: 58 in 1/52 Lambda= 0.091875 statistics sampled from 11532 (11544) to 11532 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.695), E-opt: 0.2 (0.355), width: 16 Scan time: 4.330 The best scores are: opt bits E(32554) CCDS56120.1 FAM161A gene_id:84140|Hs108|chr2 ( 716) 4686 634.1 2.2e-181 CCDS42687.2 FAM161A gene_id:84140|Hs108|chr2 ( 660) 3553 483.9 3.3e-136 CCDS9822.2 FAM161B gene_id:145483|Hs108|chr14 ( 710) 760 113.7 9.7e-25 >>CCDS56120.1 FAM161A gene_id:84140|Hs108|chr2 (716 aa) initn: 4686 init1: 4686 opt: 4686 Z-score: 3369.9 bits: 634.1 E(32554): 2.2e-181 Smith-Waterman score: 4686; 99.7% identity (99.9% similar) in 716 aa overlap (1-716:1-716) 10 20 30 40 50 60 pF1KE0 MATSHRVAKLVASSLQTPVNPITGARVAQYEREDPLKALAAAEAILEDEEEEKVAQPAGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 MATSHRVAKLVASSLQTPVNPITGARVAQYEREDPLKALAAAEAILEDEEEEKVAQPAGA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 SADLNTSFSGVDEHAPISYEDFVNFPDIHHSNEEYFKKVEELKAAHMETMAKLEKMYQDK ::::::::::::::::::::::::::::::::::::::::::::::.::::::::::::: CCDS56 SADLNTSFSGVDEHAPISYEDFVNFPDIHHSNEEYFKKVEELKAAHIETMAKLEKMYQDK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 LHLKEVQPVVIREDSLSDSSRSVSGKNSYHPVSLMTSFSEPDLGQSSSLYVSSSEEELPN :::::::::::::::::::::::: ::::::::::::::::::::::::::::::::::: CCDS56 LHLKEVQPVVIREDSLSDSSRSVSEKNSYHPVSLMTSFSEPDLGQSSSLYVSSSEEELPN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 LEKEYPRKNRMMTYAKELINNMWTDFCVEDYIRCKDTGFHAAEKRRKKRKEWVPTITVPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 LEKEYPRKNRMMTYAKELINNMWTDFCVEDYIRCKDTGFHAAEKRRKKRKEWVPTITVPE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 PFQMMIREQKKKEESMKSKSDIEMVHKALKKQEEDPEYKKKFRANPVPASVFLPLYHDLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 PFQMMIREQKKKEESMKSKSDIEMVHKALKKQEEDPEYKKKFRANPVPASVFLPLYHDLV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 KQKEERRRSLKEKSKEALLASQKPFKFIAREEQKRAAREKQLRDFLKYKKKTNRFKARPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 KQKEERRRSLKEKSKEALLASQKPFKFIAREEQKRAAREKQLRDFLKYKKKTNRFKARPI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 PRSTYGSTTNDKLKEEELYRNLRTQLRAQEHLQNSSPLPCRSACGCRNPRCPEQAVKLKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 PRSTYGSTTNDKLKEEELYRNLRTQLRAQEHLQNSSPLPCRSACGCRNPRCPEQAVKLKC 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE0 KHKVRCPTPDFEDLPERYQKHLSEHKSPKLLTVCKPFDLHASPHASIKREKILADIEADE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 KHKVRCPTPDFEDLPERYQKHLSEHKSPKLLTVCKPFDLHASPHASIKREKILADIEADE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE0 ENLKETRWPYLSPRRKSPVRCAGVNPVPCNCNPPVPTVSSRGREQAVRRSLEEKKMLEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 ENLKETRWPYLSPRRKSPVRCAGVNPVPCNCNPPVPTVSSRGREQAVRRSLEEKKMLEEE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE0 RNRILTKQKQRMKELQKLLTTRAKAYDSHQSLAQISKSRVKCLRKSEKERMREYQRELEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 RNRILTKQKQRMKELQKLLTTRAKAYDSHQSLAQISKSRVKCLRKSEKERMREYQRELEE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE0 REEKLKKRPLLFERVAQKNARMAAEKHYSNTLKALGISDEFVSKKGQSGKVLEYFNNQET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 REEKLKKRPLLFERVAQKNARMAAEKHYSNTLKALGISDEFVSKKGQSGKVLEYFNNQET 610 620 630 640 650 660 670 680 690 700 710 pF1KE0 KSVTEDKESFNEEEKIEERENGEENYFIDTNSQDSYKEKDEANEESEEEKSVEESH :::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 KSVTEDKESFNEEEKIEERENGEENYFIDTNSQDSYKEKDEANEESEEEKSVEESH 670 680 690 700 710 >>CCDS42687.2 FAM161A gene_id:84140|Hs108|chr2 (660 aa) initn: 3587 init1: 3528 opt: 3553 Z-score: 2558.8 bits: 483.9 E(32554): 3.3e-136 Smith-Waterman score: 4220; 91.9% identity (92.0% similar) in 716 aa overlap (1-716:1-660) 10 20 30 40 50 60 pF1KE0 MATSHRVAKLVASSLQTPVNPITGARVAQYEREDPLKALAAAEAILEDEEEEKVAQPAGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 MATSHRVAKLVASSLQTPVNPITGARVAQYEREDPLKALAAAEAILEDEEEEKVAQPAGA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 SADLNTSFSGVDEHAPISYEDFVNFPDIHHSNEEYFKKVEELKAAHMETMAKLEKMYQDK ::::::::::::::::::::::::::::::::::::::::::::::.::::::::::::: CCDS42 SADLNTSFSGVDEHAPISYEDFVNFPDIHHSNEEYFKKVEELKAAHIETMAKLEKMYQDK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 LHLKEVQPVVIREDSLSDSSRSVSGKNSYHPVSLMTSFSEPDLGQSSSLYVSSSEEELPN :::::::::::::::::::::::: ::::::::::::::::::::::::::::::::::: CCDS42 LHLKEVQPVVIREDSLSDSSRSVSEKNSYHPVSLMTSFSEPDLGQSSSLYVSSSEEELPN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 LEKEYPRKNRMMTYAKELINNMWTDFCVEDYIRCKDTGFHAAEKRRKKRKEWVPTITVPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 LEKEYPRKNRMMTYAKELINNMWTDFCVEDYIRCKDTGFHAAEKRRKKRKEWVPTITVPE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 PFQMMIREQKKKEESMKSKSDIEMVHKALKKQEEDPEYKKKFRANPVPASVFLPLYHDLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 PFQMMIREQKKKEESMKSKSDIEMVHKALKKQEEDPEYKKKFRANPVPASVFLPLYHDLV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 KQKEERRRSLKEKSKEALLASQKPFKFIAREEQKRAAREKQLRDFLKYKKKTNRFKARPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 KQKEERRRSLKEKSKEALLASQKPFKFIAREEQKRAAREKQLRDFLKYKKKTNRFKARPI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 PRSTYGSTTNDKLKEEELYRNLRTQLRAQEHLQNSSPLPCRSACGCRNPRCPEQAVKLKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 PRSTYGSTTNDKLKEEELYRNLRTQLRAQEHLQNSSPLPCRSACGCRNPRCPEQAVKLKC 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE0 KHKVRCPTPDFEDLPERYQKHLSEHKSPKLLTVCKPFDLHASPHASIKREKILADIEADE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 KHKVRCPTPDFEDLPERYQKHLSEHKSPKLLTVCKPFDLHASPHASIKREKILADIEADE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE0 ENLKETRWPYLSPRRKSPVRCAGVNPVPCNCNPPVPTVSSRGREQAVRRSLEEKKMLEEE :::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 ENLKETRWPYLSPRRKSPVRCAGVNPVPCNCNPPVPTVSSRGREQAVR------------ 490 500 510 520 550 560 570 580 590 600 pF1KE0 RNRILTKQKQRMKELQKLLTTRAKAYDSHQSLAQISKSRVKCLRKSEKERMREYQRELEE :::::::::::::::: CCDS42 --------------------------------------------KSEKERMREYQRELEE 530 540 610 620 630 640 650 660 pF1KE0 REEKLKKRPLLFERVAQKNARMAAEKHYSNTLKALGISDEFVSKKGQSGKVLEYFNNQET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 REEKLKKRPLLFERVAQKNARMAAEKHYSNTLKALGISDEFVSKKGQSGKVLEYFNNQET 550 560 570 580 590 600 670 680 690 700 710 pF1KE0 KSVTEDKESFNEEEKIEERENGEENYFIDTNSQDSYKEKDEANEESEEEKSVEESH :::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 KSVTEDKESFNEEEKIEERENGEENYFIDTNSQDSYKEKDEANEESEEEKSVEESH 610 620 630 640 650 660 >>CCDS9822.2 FAM161B gene_id:145483|Hs108|chr14 (710 aa) initn: 703 init1: 327 opt: 760 Z-score: 557.6 bits: 113.7 E(32554): 9.7e-25 Smith-Waterman score: 832; 34.8% identity (62.6% similar) in 492 aa overlap (232-708:228-704) 210 220 230 240 250 260 pF1KE0 MWTDFCVEDYIRCKDTGFHAAEKRRKKRKEWVPTITVPEPFQMMIREQKKKEESMKSKSD :. .::::.::.: .:: .:: : . : .. CCDS98 LNNLPSNIPRPQTQPPSGSRPPSQHRSVSSWASSITVPRPFRMTLREARKKAEWLGSPAS 200 210 220 230 240 250 270 280 290 300 310 320 pF1KE0 IEMVHKALKKQ-EEDPEYKKKFRANPVPASVFLPLYHDLVKQKEERRRSLKEKSKEALLA .:. .. ..: ::. : ...:::.:::: :.::::.......: ::.. .: :: ::. CCDS98 FEQERQRAQRQGEEEAECHRQFRAQPVPAHVYLPLYQEIMERSEARRQAGIQKRKELLLS 260 270 280 290 300 310 330 340 350 360 370 pF1KE0 SQKPFKFIAREEQ-KRAAREKQLRDFLKYKKKTNRFKA-RPIPRSTYGSTTNDKLKEEEL : :::.:. .::: :.:::...: . : .. :: : ::.: . .:::.: :: CCDS98 SLKPFSFLEKEEQLKEAARQRDLAA--TAEAKISKQKATRRIPKSILEPALGDKLQEAEL 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 YRNLRTQLRAQEHLQ-NSSPLPCRSACGCRNPRCPE--QAVKLKCKH-------KVRCPT .:..: :.:: . :: :::. : . .:: : :: : .: . CCDS98 FRKIRIQMRALDMLQMASSPIASSSNRANPQPRTATRTQQEKLGFLHTNFRFQPRVNPVV 380 390 400 410 420 430 430 440 450 460 470 480 pF1KE0 PDFEDLPERYQKHLSEHKSPKLLTVCKPFDLHASPHASIKREKILADIEADEENLKETRW ::.: : . .:.. .... . : ::: :... .: : ... . CCDS98 PDYEGLYKAFQRRAAKRRETQEATRNKPFLLRTANLRHPQRPCDAATTGRRQDSPQPPAT 440 450 460 470 480 490 490 500 510 520 530 540 pF1KE0 PYLSPRRKSPVRCAGVNPVPCNCNPPVPTVSSRGREQAVRRSLEEKKMLEEERNRILTKQ : :: .: .:. . : : : ..: ::.::: .:: :: .: . : . CCDS98 PL--PRSRS---LSGLASLSANTLPVHITDATRKRESAVRSALE-KKNKADESIQWLEIH 500 510 520 530 540 550 560 570 580 590 600 pF1KE0 KQRMKELQKLLTTRAKAYDSHQSLAQISKSRVKCLRKSEKERMREYQRELEEREEKLKKR :.. . ..: .: ::::.: :.:: .. :...: :.....: .::..:::: ..... : CCDS98 KKKSQAMSKSVTLRAKAMDPHKSLEEVFKAKLKENRNNDRKRAKEYKKELEEMKQRIQTR 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE0 PLLFERVAQKNARMAAEKHYSNTLKALGISDEFVSKKGQSGKVLEYFNNQETKSVTEDKE : :::.::. :. ::. : .::: :. ..:: .:::. ... :: .. .: CCDS98 PYLFEQVAKDLAKKEAEQWYLDTLKQAGLEEDFVRNKGQGTRAV-----QEKETKIKDFP 610 620 630 640 650 660 670 680 690 700 710 pF1KE0 SFNEEEKIEER--ENGEENYFIDTNSQDSYKEKDEANEESEEEKSVEESH :.: :. : :.: :. . . : : .: ...: : CCDS98 RFQETTKLSIRDPEQGLEGSLEQPASP--RKVLEELSHQSPENLVSLA 670 680 690 700 710 716 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 16:08:58 2016 done: Thu Nov 3 16:08:58 2016 Total Scan time: 4.330 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]