FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0326, 639 aa 1>>>pF1KE0326 639 - 639 aa - 639 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.0157+/-0.000352; mu= 16.2705+/- 0.022 mean_var=83.2168+/-16.675, 0's: 0 Z-trim(116.0): 125 B-trim: 17 in 2/49 Lambda= 0.140595 statistics sampled from 26800 (26927) to 26800 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.68), E-opt: 0.2 (0.316), width: 16 Scan time: 9.250 The best scores are: opt bits E(85289) NP_473451 (OMIM: 615131) polypeptide N-acetylgalac ( 639) 4416 905.7 0 NP_001305980 (OMIM: 615131) polypeptide N-acetylga ( 617) 4081 837.7 0 XP_005264909 (OMIM: 615131) PREDICTED: polypeptide ( 593) 4079 837.3 0 XP_016861172 (OMIM: 615131) PREDICTED: polypeptide ( 372) 2639 545.1 1.6e-154 XP_016861171 (OMIM: 615131) PREDICTED: polypeptide ( 372) 2639 545.1 1.6e-154 XP_016861173 (OMIM: 615131) PREDICTED: polypeptide ( 350) 2304 477.2 4.4e-134 NP_003765 (OMIM: 603565) polypeptide N-acetylgalac ( 578) 1371 288.0 6.3e-77 NP_078918 (OMIM: 608812,610290) polypeptide N-acet ( 581) 1369 287.6 8.3e-77 XP_016870622 (OMIM: 608812,610290) PREDICTED: poly ( 497) 1306 274.8 5.1e-73 XP_011517320 (OMIM: 608812,610290) PREDICTED: poly ( 507) 1306 274.8 5.2e-73 XP_016859259 (OMIM: 601756) PREDICTED: polypeptide ( 633) 1264 266.3 2.3e-70 XP_011509231 (OMIM: 601756) PREDICTED: polypeptide ( 633) 1264 266.3 2.3e-70 XP_005246506 (OMIM: 601756) PREDICTED: polypeptide ( 633) 1264 266.3 2.3e-70 NP_004473 (OMIM: 601756) polypeptide N-acetylgalac ( 633) 1264 266.3 2.3e-70 NP_009141 (OMIM: 605148) polypeptide N-acetylgalac ( 622) 1260 265.5 4e-70 XP_006719277 (OMIM: 605148) PREDICTED: polypeptide ( 622) 1260 265.5 4e-70 XP_011536121 (OMIM: 605148) PREDICTED: polypeptide ( 622) 1260 265.5 4e-70 XP_011536124 (OMIM: 605148) PREDICTED: polypeptide ( 622) 1260 265.5 4e-70 XP_005268664 (OMIM: 605148) PREDICTED: polypeptide ( 622) 1260 265.5 4e-70 XP_016874234 (OMIM: 605148) PREDICTED: polypeptide ( 622) 1260 265.5 4e-70 XP_016874233 (OMIM: 605148) PREDICTED: polypeptide ( 622) 1260 265.5 4e-70 NP_001305981 (OMIM: 615131) polypeptide N-acetylga ( 169) 1216 256.3 6.4e-68 NP_938080 (OMIM: 608043) polypeptide N-acetylgalac ( 603) 1220 257.4 1.1e-67 XP_005258296 (OMIM: 602273) PREDICTED: polypeptide ( 559) 1156 244.4 8.2e-64 XP_016881181 (OMIM: 602273) PREDICTED: polypeptide ( 559) 1156 244.4 8.2e-64 NP_065207 (OMIM: 602273) polypeptide N-acetylgalac ( 559) 1156 244.4 8.2e-64 NP_001030017 (OMIM: 615138) polypeptide N-acetylga ( 601) 1131 239.3 2.9e-62 XP_016863733 (OMIM: 615138) PREDICTED: polypeptide ( 609) 1131 239.3 3e-62 XP_011530295 (OMIM: 615138) PREDICTED: polypeptide ( 522) 1128 238.7 3.9e-62 NP_055383 (OMIM: 615129) polypeptide N-acetylgalac ( 940) 1128 238.8 6.5e-62 NP_443149 (OMIM: 608369) polypeptide N-acetylgalac ( 556) 1105 234.1 1.1e-60 XP_016858750 (OMIM: 608369) PREDICTED: polypeptide ( 556) 1105 234.1 1.1e-60 NP_001316797 (OMIM: 615129) polypeptide N-acetylga ( 470) 1102 233.4 1.4e-60 NP_001278795 (OMIM: 602274) polypeptide N-acetylga ( 533) 1089 230.8 9.7e-60 XP_016858748 (OMIM: 608369) PREDICTED: polypeptide ( 571) 1089 230.8 1e-59 NP_004472 (OMIM: 602274) polypeptide N-acetylgalac ( 571) 1089 230.8 1e-59 XP_016858747 (OMIM: 608369) PREDICTED: polypeptide ( 571) 1089 230.8 1e-59 XP_011508839 (OMIM: 608369) PREDICTED: polypeptide ( 571) 1089 230.8 1e-59 XP_016858726 (OMIM: 615129) PREDICTED: polypeptide ( 956) 1091 231.3 1.2e-59 NP_001288556 (OMIM: 608369) polypeptide N-acetylga ( 561) 1044 221.7 5.6e-57 XP_016858749 (OMIM: 608369) PREDICTED: polypeptide ( 561) 1044 221.7 5.6e-57 NP_001291443 (OMIM: 615130) polypeptide N-acetylga ( 527) 1035 219.8 1.9e-56 NP_001316024 (OMIM: 608225) polypeptide N-acetylga ( 517) 1032 219.2 2.8e-56 NP_660335 (OMIM: 615133) inactive polypeptide N-ac ( 443) 1031 219.0 2.9e-56 XP_006715925 (OMIM: 615133) PREDICTED: inactive po ( 443) 1031 219.0 2.9e-56 NP_078848 (OMIM: 608225) polypeptide N-acetylgalac ( 552) 1032 219.2 3e-56 XP_016860395 (OMIM: 608225) PREDICTED: polypeptide ( 563) 1032 219.3 3.1e-56 XP_016867282 (OMIM: 615133) PREDICTED: inactive po ( 496) 1031 219.0 3.2e-56 NP_001240756 (OMIM: 608225) polypeptide N-acetylga ( 532) 1031 219.0 3.4e-56 NP_001316025 (OMIM: 608225) polypeptide N-acetylga ( 532) 1031 219.0 3.4e-56 >>NP_473451 (OMIM: 615131) polypeptide N-acetylgalactosa (639 aa) initn: 4416 init1: 4416 opt: 4416 Z-score: 4839.4 bits: 905.7 E(85289): 0 Smith-Waterman score: 4416; 99.8% identity (99.8% similar) in 639 aa overlap (1-639:1-639) 10 20 30 40 50 60 pF1KE0 MLLRKRYRHRPCRLQFLLLLLMLGCVLMMVAMLHPPHHTLHQTDTAQASKHSPEARYRLD ::::::::::::::::::::::::::::::::::::::::::: :::::::::::::::: NP_473 MLLRKRYRHRPCRLQFLLLLLMLGCVLMMVAMLHPPHHTLHQTVTAQASKHSPEARYRLD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 FGESQDWVLEAEDEGEEYSPLEGLPPFISLREDQLLVAVALPQARRNQSQGRRGGSYRLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_473 FGESQDWVLEAEDEGEEYSPLEGLPPFISLREDQLLVAVALPQARRNQSQGRRGGSYRLI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 KQPRRQDKEAPKRDWGADEDGEVSEEEELTPFSLDPRGLQEALSARIPLQRALPEVRHPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_473 KQPRRQDKEAPKRDWGADEDGEVSEEEELTPFSLDPRGLQEALSARIPLQRALPEVRHPL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 CLQQHPQDSLPTASVILCFHDEAWSTLLRTVHSILDTVPRAFLKEIILVDDLSQQGQLKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_473 CLQQHPQDSLPTASVILCFHDEAWSTLLRTVHSILDTVPRAFLKEIILVDDLSQQGQLKS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 ALSEYVARLEGVKLLRSNKRLGAIRARMLGATRATGDVLVFMDAHCECHPGWLEPLLSRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_473 ALSEYVARLEGVKLLRSNKRLGAIRARMLGATRATGDVLVFMDAHCECHPGWLEPLLSRI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 AGDRSRVVSPVIDVIDWKTFQYYPSKDLQRGVLDWKLDFHWEPLPEHVRKALQSPISPIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_473 AGDRSRVVSPVIDVIDWKTFQYYPSKDLQRGVLDWKLDFHWEPLPEHVRKALQSPISPIR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 SPVVPGEVVAMDRHYFQNTGAYDSLMSLRGGENLELSFKAWLCGGSVEILPCSRVGHIYQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_473 SPVVPGEVVAMDRHYFQNTGAYDSLMSLRGGENLELSFKAWLCGGSVEILPCSRVGHIYQ 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE0 NQDSHSPLDQEATLRNRVRIAETWLGSFKETFYKHSPEAFSLSKAEKPDCMERLQLQRRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_473 NQDSHSPLDQEATLRNRVRIAETWLGSFKETFYKHSPEAFSLSKAEKPDCMERLQLQRRL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE0 GCRTFHWFLANVYPELYPSEPRPSFSGKLHNTGLGLCADCQAEGDILGCPMVLAPCSDSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_473 GCRTFHWFLANVYPELYPSEPRPSFSGKLHNTGLGLCADCQAEGDILGCPMVLAPCSDSR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE0 QQQYLQHTSRKEIHFGSPQHLCFAVRQEQVILQNCTEEGLAIHQQHWDFQENGMIVHILS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_473 QQQYLQHTSRKEIHFGSPQHLCFAVRQEQVILQNCTEEGLAIHQQHWDFQENGMIVHILS 550 560 570 580 590 600 610 620 630 pF1KE0 GKCMEAVVQENNKDLYLRPCDGKARQQWRFDQINAVDER ::::::::::::::::::::::::::::::::::::::: NP_473 GKCMEAVVQENNKDLYLRPCDGKARQQWRFDQINAVDER 610 620 630 >>NP_001305980 (OMIM: 615131) polypeptide N-acetylgalact (617 aa) initn: 4109 init1: 4081 opt: 4081 Z-score: 4472.4 bits: 837.7 E(85289): 0 Smith-Waterman score: 4081; 99.7% identity (99.8% similar) in 592 aa overlap (1-592:1-592) 10 20 30 40 50 60 pF1KE0 MLLRKRYRHRPCRLQFLLLLLMLGCVLMMVAMLHPPHHTLHQTDTAQASKHSPEARYRLD ::::::::::::::::::::::::::::::::::::::::::: :::::::::::::::: NP_001 MLLRKRYRHRPCRLQFLLLLLMLGCVLMMVAMLHPPHHTLHQTVTAQASKHSPEARYRLD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 FGESQDWVLEAEDEGEEYSPLEGLPPFISLREDQLLVAVALPQARRNQSQGRRGGSYRLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FGESQDWVLEAEDEGEEYSPLEGLPPFISLREDQLLVAVALPQARRNQSQGRRGGSYRLI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 KQPRRQDKEAPKRDWGADEDGEVSEEEELTPFSLDPRGLQEALSARIPLQRALPEVRHPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KQPRRQDKEAPKRDWGADEDGEVSEEEELTPFSLDPRGLQEALSARIPLQRALPEVRHPL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 CLQQHPQDSLPTASVILCFHDEAWSTLLRTVHSILDTVPRAFLKEIILVDDLSQQGQLKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CLQQHPQDSLPTASVILCFHDEAWSTLLRTVHSILDTVPRAFLKEIILVDDLSQQGQLKS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 ALSEYVARLEGVKLLRSNKRLGAIRARMLGATRATGDVLVFMDAHCECHPGWLEPLLSRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALSEYVARLEGVKLLRSNKRLGAIRARMLGATRATGDVLVFMDAHCECHPGWLEPLLSRI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 AGDRSRVVSPVIDVIDWKTFQYYPSKDLQRGVLDWKLDFHWEPLPEHVRKALQSPISPIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AGDRSRVVSPVIDVIDWKTFQYYPSKDLQRGVLDWKLDFHWEPLPEHVRKALQSPISPIR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 SPVVPGEVVAMDRHYFQNTGAYDSLMSLRGGENLELSFKAWLCGGSVEILPCSRVGHIYQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SPVVPGEVVAMDRHYFQNTGAYDSLMSLRGGENLELSFKAWLCGGSVEILPCSRVGHIYQ 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE0 NQDSHSPLDQEATLRNRVRIAETWLGSFKETFYKHSPEAFSLSKAEKPDCMERLQLQRRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NQDSHSPLDQEATLRNRVRIAETWLGSFKETFYKHSPEAFSLSKAEKPDCMERLQLQRRL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE0 GCRTFHWFLANVYPELYPSEPRPSFSGKLHNTGLGLCADCQAEGDILGCPMVLAPCSDSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GCRTFHWFLANVYPELYPSEPRPSFSGKLHNTGLGLCADCQAEGDILGCPMVLAPCSDSR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE0 QQQYLQHTSRKEIHFGSPQHLCFAVRQEQVILQNCTEEGLAIHQQHWDFQENGMIVHILS :::::::::::::::::::::::::::::::::::::::::::::::::::. NP_001 QQQYLQHTSRKEIHFGSPQHLCFAVRQEQVILQNCTEEGLAIHQQHWDFQEDENRANSAA 550 560 570 580 590 600 610 620 630 pF1KE0 GKCMEAVVQENNKDLYLRPCDGKARQQWRFDQINAVDER NP_001 AEAYQRPLTFQQIVNNG 610 >>XP_005264909 (OMIM: 615131) PREDICTED: polypeptide N-a (593 aa) initn: 4079 init1: 4079 opt: 4079 Z-score: 4470.5 bits: 837.3 E(85289): 0 Smith-Waterman score: 4079; 99.8% identity (99.8% similar) in 591 aa overlap (1-591:1-591) 10 20 30 40 50 60 pF1KE0 MLLRKRYRHRPCRLQFLLLLLMLGCVLMMVAMLHPPHHTLHQTDTAQASKHSPEARYRLD ::::::::::::::::::::::::::::::::::::::::::: :::::::::::::::: XP_005 MLLRKRYRHRPCRLQFLLLLLMLGCVLMMVAMLHPPHHTLHQTVTAQASKHSPEARYRLD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 FGESQDWVLEAEDEGEEYSPLEGLPPFISLREDQLLVAVALPQARRNQSQGRRGGSYRLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FGESQDWVLEAEDEGEEYSPLEGLPPFISLREDQLLVAVALPQARRNQSQGRRGGSYRLI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 KQPRRQDKEAPKRDWGADEDGEVSEEEELTPFSLDPRGLQEALSARIPLQRALPEVRHPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KQPRRQDKEAPKRDWGADEDGEVSEEEELTPFSLDPRGLQEALSARIPLQRALPEVRHPL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 CLQQHPQDSLPTASVILCFHDEAWSTLLRTVHSILDTVPRAFLKEIILVDDLSQQGQLKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CLQQHPQDSLPTASVILCFHDEAWSTLLRTVHSILDTVPRAFLKEIILVDDLSQQGQLKS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 ALSEYVARLEGVKLLRSNKRLGAIRARMLGATRATGDVLVFMDAHCECHPGWLEPLLSRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ALSEYVARLEGVKLLRSNKRLGAIRARMLGATRATGDVLVFMDAHCECHPGWLEPLLSRI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 AGDRSRVVSPVIDVIDWKTFQYYPSKDLQRGVLDWKLDFHWEPLPEHVRKALQSPISPIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AGDRSRVVSPVIDVIDWKTFQYYPSKDLQRGVLDWKLDFHWEPLPEHVRKALQSPISPIR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 SPVVPGEVVAMDRHYFQNTGAYDSLMSLRGGENLELSFKAWLCGGSVEILPCSRVGHIYQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SPVVPGEVVAMDRHYFQNTGAYDSLMSLRGGENLELSFKAWLCGGSVEILPCSRVGHIYQ 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE0 NQDSHSPLDQEATLRNRVRIAETWLGSFKETFYKHSPEAFSLSKAEKPDCMERLQLQRRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NQDSHSPLDQEATLRNRVRIAETWLGSFKETFYKHSPEAFSLSKAEKPDCMERLQLQRRL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE0 GCRTFHWFLANVYPELYPSEPRPSFSGKLHNTGLGLCADCQAEGDILGCPMVLAPCSDSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GCRTFHWFLANVYPELYPSEPRPSFSGKLHNTGLGLCADCQAEGDILGCPMVLAPCSDSR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE0 QQQYLQHTSRKEIHFGSPQHLCFAVRQEQVILQNCTEEGLAIHQQHWDFQENGMIVHILS ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QQQYLQHTSRKEIHFGSPQHLCFAVRQEQVILQNCTEEGLAIHQQHWDFQEVS 550 560 570 580 590 610 620 630 pF1KE0 GKCMEAVVQENNKDLYLRPCDGKARQQWRFDQINAVDER >>XP_016861172 (OMIM: 615131) PREDICTED: polypeptide N-a (372 aa) initn: 2639 init1: 2639 opt: 2639 Z-score: 2895.0 bits: 545.1 E(85289): 1.6e-154 Smith-Waterman score: 2639; 100.0% identity (100.0% similar) in 372 aa overlap (268-639:1-372) 240 250 260 270 280 290 pF1KE0 LKSALSEYVARLEGVKLLRSNKRLGAIRARMLGATRATGDVLVFMDAHCECHPGWLEPLL :::::::::::::::::::::::::::::: XP_016 MLGATRATGDVLVFMDAHCECHPGWLEPLL 10 20 30 300 310 320 330 340 350 pF1KE0 SRIAGDRSRVVSPVIDVIDWKTFQYYPSKDLQRGVLDWKLDFHWEPLPEHVRKALQSPIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SRIAGDRSRVVSPVIDVIDWKTFQYYPSKDLQRGVLDWKLDFHWEPLPEHVRKALQSPIS 40 50 60 70 80 90 360 370 380 390 400 410 pF1KE0 PIRSPVVPGEVVAMDRHYFQNTGAYDSLMSLRGGENLELSFKAWLCGGSVEILPCSRVGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PIRSPVVPGEVVAMDRHYFQNTGAYDSLMSLRGGENLELSFKAWLCGGSVEILPCSRVGH 100 110 120 130 140 150 420 430 440 450 460 470 pF1KE0 IYQNQDSHSPLDQEATLRNRVRIAETWLGSFKETFYKHSPEAFSLSKAEKPDCMERLQLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IYQNQDSHSPLDQEATLRNRVRIAETWLGSFKETFYKHSPEAFSLSKAEKPDCMERLQLQ 160 170 180 190 200 210 480 490 500 510 520 530 pF1KE0 RRLGCRTFHWFLANVYPELYPSEPRPSFSGKLHNTGLGLCADCQAEGDILGCPMVLAPCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RRLGCRTFHWFLANVYPELYPSEPRPSFSGKLHNTGLGLCADCQAEGDILGCPMVLAPCS 220 230 240 250 260 270 540 550 560 570 580 590 pF1KE0 DSRQQQYLQHTSRKEIHFGSPQHLCFAVRQEQVILQNCTEEGLAIHQQHWDFQENGMIVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DSRQQQYLQHTSRKEIHFGSPQHLCFAVRQEQVILQNCTEEGLAIHQQHWDFQENGMIVH 280 290 300 310 320 330 600 610 620 630 pF1KE0 ILSGKCMEAVVQENNKDLYLRPCDGKARQQWRFDQINAVDER :::::::::::::::::::::::::::::::::::::::::: XP_016 ILSGKCMEAVVQENNKDLYLRPCDGKARQQWRFDQINAVDER 340 350 360 370 >>XP_016861171 (OMIM: 615131) PREDICTED: polypeptide N-a (372 aa) initn: 2639 init1: 2639 opt: 2639 Z-score: 2895.0 bits: 545.1 E(85289): 1.6e-154 Smith-Waterman score: 2639; 100.0% identity (100.0% similar) in 372 aa overlap (268-639:1-372) 240 250 260 270 280 290 pF1KE0 LKSALSEYVARLEGVKLLRSNKRLGAIRARMLGATRATGDVLVFMDAHCECHPGWLEPLL :::::::::::::::::::::::::::::: XP_016 MLGATRATGDVLVFMDAHCECHPGWLEPLL 10 20 30 300 310 320 330 340 350 pF1KE0 SRIAGDRSRVVSPVIDVIDWKTFQYYPSKDLQRGVLDWKLDFHWEPLPEHVRKALQSPIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SRIAGDRSRVVSPVIDVIDWKTFQYYPSKDLQRGVLDWKLDFHWEPLPEHVRKALQSPIS 40 50 60 70 80 90 360 370 380 390 400 410 pF1KE0 PIRSPVVPGEVVAMDRHYFQNTGAYDSLMSLRGGENLELSFKAWLCGGSVEILPCSRVGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PIRSPVVPGEVVAMDRHYFQNTGAYDSLMSLRGGENLELSFKAWLCGGSVEILPCSRVGH 100 110 120 130 140 150 420 430 440 450 460 470 pF1KE0 IYQNQDSHSPLDQEATLRNRVRIAETWLGSFKETFYKHSPEAFSLSKAEKPDCMERLQLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IYQNQDSHSPLDQEATLRNRVRIAETWLGSFKETFYKHSPEAFSLSKAEKPDCMERLQLQ 160 170 180 190 200 210 480 490 500 510 520 530 pF1KE0 RRLGCRTFHWFLANVYPELYPSEPRPSFSGKLHNTGLGLCADCQAEGDILGCPMVLAPCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RRLGCRTFHWFLANVYPELYPSEPRPSFSGKLHNTGLGLCADCQAEGDILGCPMVLAPCS 220 230 240 250 260 270 540 550 560 570 580 590 pF1KE0 DSRQQQYLQHTSRKEIHFGSPQHLCFAVRQEQVILQNCTEEGLAIHQQHWDFQENGMIVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DSRQQQYLQHTSRKEIHFGSPQHLCFAVRQEQVILQNCTEEGLAIHQQHWDFQENGMIVH 280 290 300 310 320 330 600 610 620 630 pF1KE0 ILSGKCMEAVVQENNKDLYLRPCDGKARQQWRFDQINAVDER :::::::::::::::::::::::::::::::::::::::::: XP_016 ILSGKCMEAVVQENNKDLYLRPCDGKARQQWRFDQINAVDER 340 350 360 370 >>XP_016861173 (OMIM: 615131) PREDICTED: polypeptide N-a (350 aa) initn: 2332 init1: 2304 opt: 2304 Z-score: 2528.2 bits: 477.2 E(85289): 4.4e-134 Smith-Waterman score: 2304; 99.7% identity (100.0% similar) in 325 aa overlap (268-592:1-325) 240 250 260 270 280 290 pF1KE0 LKSALSEYVARLEGVKLLRSNKRLGAIRARMLGATRATGDVLVFMDAHCECHPGWLEPLL :::::::::::::::::::::::::::::: XP_016 MLGATRATGDVLVFMDAHCECHPGWLEPLL 10 20 30 300 310 320 330 340 350 pF1KE0 SRIAGDRSRVVSPVIDVIDWKTFQYYPSKDLQRGVLDWKLDFHWEPLPEHVRKALQSPIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SRIAGDRSRVVSPVIDVIDWKTFQYYPSKDLQRGVLDWKLDFHWEPLPEHVRKALQSPIS 40 50 60 70 80 90 360 370 380 390 400 410 pF1KE0 PIRSPVVPGEVVAMDRHYFQNTGAYDSLMSLRGGENLELSFKAWLCGGSVEILPCSRVGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PIRSPVVPGEVVAMDRHYFQNTGAYDSLMSLRGGENLELSFKAWLCGGSVEILPCSRVGH 100 110 120 130 140 150 420 430 440 450 460 470 pF1KE0 IYQNQDSHSPLDQEATLRNRVRIAETWLGSFKETFYKHSPEAFSLSKAEKPDCMERLQLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IYQNQDSHSPLDQEATLRNRVRIAETWLGSFKETFYKHSPEAFSLSKAEKPDCMERLQLQ 160 170 180 190 200 210 480 490 500 510 520 530 pF1KE0 RRLGCRTFHWFLANVYPELYPSEPRPSFSGKLHNTGLGLCADCQAEGDILGCPMVLAPCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RRLGCRTFHWFLANVYPELYPSEPRPSFSGKLHNTGLGLCADCQAEGDILGCPMVLAPCS 220 230 240 250 260 270 540 550 560 570 580 590 pF1KE0 DSRQQQYLQHTSRKEIHFGSPQHLCFAVRQEQVILQNCTEEGLAIHQQHWDFQENGMIVH ::::::::::::::::::::::::::::::::::::::::::::::::::::::. XP_016 DSRQQQYLQHTSRKEIHFGSPQHLCFAVRQEQVILQNCTEEGLAIHQQHWDFQEDENRAN 280 290 300 310 320 330 600 610 620 630 pF1KE0 ILSGKCMEAVVQENNKDLYLRPCDGKARQQWRFDQINAVDER XP_016 SAAAEAYQRPLTFQQIVNNG 340 350 >>NP_003765 (OMIM: 603565) polypeptide N-acetylgalactosa (578 aa) initn: 1143 init1: 588 opt: 1371 Z-score: 1502.1 bits: 288.0 E(85289): 6.3e-77 Smith-Waterman score: 1374; 40.6% identity (67.1% similar) in 556 aa overlap (99-632:29-578) 70 80 90 100 110 pF1KE0 LEAEDEGEEYSPLEGLPPFISLREDQLLVAVALPQARRNQSQGRRGGSYRL--------- :. .: . ...:. :: :: NP_003 MAVRWTWAGKSCLLLAFLTVAYIFVELLVSTFHASAGAGRARELGSRRLSDLQKNTED 10 20 30 40 50 120 130 140 150 160 170 pF1KE0 IKQPRRQDKEAPKR---DWGADEDGEVSEEEELTPFSLDPR-GLQEALSARIPLQRALPE ...: . : .: .:: ...:.: : : ... :: :: :.: . . NP_003 LSRPLYKKPPADSRALGEWGKASKLQLNEDELKQQEELIERYAINIYLSDRISLHRHIED 60 70 80 90 100 110 180 190 200 210 220 230 pF1KE0 VRHPLCL-QQHPQDSLPTASVILCFHDEAWSTLLRTVHSILDTVPRAFLKEIILVDDLSQ : : :. .:::.:::. :..:::::::::.::.:.: : ..:::::::::::. NP_003 KRMYECKSQKFNYRTLPTTSVIIAFYNEAWSTLLRTIHSVLETSPAVLLKEIILVDDLSD 120 130 140 150 160 170 240 250 260 270 280 290 pF1KE0 QGQLKSALSEYVARLEGVKLLRSNKRLGAIRARMLGATRATGDVLVFMDAHCECHPGWLE . ::. : :.. :. :.:.:.::: : .:::..::: ::::::.:.: ::::. :::: NP_003 RVYLKTQLETYISNLDRVRLIRTNKREGLVRARLIGATFATGDVLTFLDCHCECNSGWLE 180 190 200 210 220 230 300 310 320 330 340 350 pF1KE0 PLLSRIAGDRSRVVSPVIDVIDWKTFQYYPS-KDLQRGVLDWKLDFHWEPLPEHVRKALQ ::: ::. :.. :: ::::.:::.::..: . . . : .::.: :.:. .:.. : NP_003 PLLERIGRDETAVVCPVIDTIDWNTFEFYMQIGEPMIGGFDWRLTFQWHSVPKQERDRRI 240 250 260 270 280 290 360 370 380 390 400 410 pF1KE0 SPISPIRSPVVPGEVVAMDRHYFQNTGAYDSLMSLRGGENLELSFKAWLCGGSVEILPCS : :.:::::.. : . :....::: :.::. : . :::::::::..: :::..:: ::: NP_003 SRIDPIRSPTMAGGLFAVSKKYFQYLGTYDTGMEVWGGENLELSFRVWQCGGKLEIHPCS 300 310 320 330 340 350 420 430 440 450 460 470 pF1KE0 RVGHIYQNQDSHSPLDQEATLRNRVRIAETWLGSFKETFYKHSPEAFSLSKAEKPDCMER .:::.. .. .: . :.: .: ::.:. .:: ::...: : : : :: NP_003 HVGHVFPKR---APYARPNFLQNTARAAEVWMDEYKEHFYNRNPPA---RKEAYGDISER 360 370 380 390 400 410 480 490 500 510 520 530 pF1KE0 LQLQRRLGCRTFHWFLANVYPELYPSEPRPSFSGKLHNTGLGL-CADCQA-EGDILGCPM :..:: :..: :.: ::.:.:. : ::.. : ... :.. : : .. ... : . NP_003 KLLRERLRCKSFDWYLKNVFPNLHVPEDRPGWHGAIRSRGISSECLDYNSPDNNPTGANL 420 430 440 450 460 470 540 550 560 570 580 pF1KE0 VLAPCSDSRQQQYLQHTSRKEIHFGSPQHLCFAVRQEQ--VILQNCTEEGLAIHQQH-WD : : . .:....:: :::.:.: .:: : ... : .::: ..:. . . : NP_003 SLFGCHGQGGNQFFEYTSNKEIRFNSVTELCAEVPEQKNYVGMQNCPKDGFPVPANIIWH 480 490 500 510 520 530 590 600 610 620 630 pF1KE0 FQENGMIVHILSGKCMEAV-VQENNKDLYLRPCDGKARQQ-WRFDQINAVDER :.:.: : : :: :. : . :. :. .: ::. ..: : :.. NP_003 FKEDGTIFHPHSGLCLSAYRTPEGRPDVQMRTCDALDKNQIWSFEK 540 550 560 570 >>NP_078918 (OMIM: 608812,610290) polypeptide N-acetylga (581 aa) initn: 1187 init1: 558 opt: 1369 Z-score: 1499.9 bits: 287.6 E(85289): 8.3e-77 Smith-Waterman score: 1369; 42.4% identity (67.5% similar) in 550 aa overlap (100-632:48-578) 70 80 90 100 110 120 pF1KE0 EAEDEGEEYSPLEGLPPFISLREDQLLVAVALPQARRNQSQGRRGGSYRLIKQPRRQDKE : : :. ::: .: NP_078 REALLVLLALLALAGLGSVLRAQRGAGAGAAEPGPPRTPRPGRR--------EPVMPRPP 20 30 40 50 60 130 140 150 160 170 180 pF1KE0 APKRDWGADEDGEV------SEEEELTPFSLDPRGLQEALSARIPLQRALPEVRHPLCLQ .: :: ::. .:: .: :. . .. :: :: :.: ::: .::: . NP_078 VPANALGAR--GEAVRLQLQGEELRLQEESVRLHQINIYLSDRISLHRRLPERWNPLCKE 70 80 90 100 110 120 190 200 210 220 230 240 pF1KE0 Q-HPQDSLPTASVILCFHDEAWSTLLRTVHSILDTVPRAFLKEIILVDDLSQQGQLKSAL . . :.:: .:::. :..::::::::::.:.:.: : .:.:.::::: :.. .:: : NP_078 KKYDYDNLPRTSVIIAFYNEAWSTLLRTVYSVLETSPDILLEEVILVDDYSDREHLKERL 130 140 150 160 170 180 250 260 270 280 290 300 pF1KE0 SEYVARLEGVKLLRSNKRLGAIRARMLGATRATGDVLVFMDAHCECHPGWLEPLLSRIAG .. .. : :.:.:.::: : .:::.:::. : ::::.:.: ::::: :::::::.:: NP_078 ANELSGLPKVRLIRANKREGLVRARLLGASAARGDVLTFLDCHCECHEGWLEPLLQRIHE 190 200 210 220 230 240 310 320 330 340 350 360 pF1KE0 DRSRVVSPVIDVIDWKTFQYYP-SKDLQRGVLDWKLDFHWEPLPEHVRKALQSPISPIRS ..: :: ::::::::.::.: : . : : .::.: : :. .::. : .:::.. ::: NP_078 EESAVVCPVIDVIDWNTFEYLGNSGEPQIGGFDWRLVFTWHTVPERERIRMQSPVDVIRS 250 260 270 280 290 300 370 380 390 400 410 420 pF1KE0 PVVPGEVVAMDRHYFQNTGAYDSLMSLRGGENLELSFKAWLCGGSVEILPCSRVGHIYQN :.. : . :....::. :.::. : . ::::::.::. : ::: .: :::.:::.. . NP_078 PTMAGGLFAVSKKYFEYLGSYDTGMEVWGGENLEFSFRIWQCGGVLETHPCSHVGHVFPK 310 320 330 340 350 360 430 440 450 460 470 480 pF1KE0 QDSHSPLDQEATLRNRVRIAETWLGSFKETFYKHSPEAFSLSKAEK-PDCMERLQLQRRL : .: ... .: : :: ::.:. ::: .:...:.: . : : :: ::. .: NP_078 Q---APYSRNKALANSVRAAEVWMDEFKELYYHRNPRA----RLEPFGDVTERKQLRDKL 370 380 390 400 410 420 490 500 510 520 530 pF1KE0 GCRTFHWFLANVYPELYPSEPRPSFSGKLHNTGL-GLCADCQA--EGDILGCPMVLAPCS :. :.::: .:::::. : ::.: : :.: :: : : . :..:.: ..: : NP_078 QCKDFKWFLETVYPELHVPEDRPGFFGMLQNKGLTDYCFDYNPPDENQIVGHQVILYLCH 430 440 450 460 470 480 540 550 560 570 580 590 pF1KE0 DSRQQQYLQHTSRKEIHFGSPQ-HLCFAVR--QEQVILQNCTEEGLAIHQQHWDFQENGM :.:....::.:::.... : . :.::. .. .:.. : : : ..:.. .::.: NP_078 GMGQNQFFEYTSQKEIRYNTHQPEGCIAVEAGMDTLIMHLCEE--TAPENQKFILQEDGS 490 500 510 520 530 600 610 620 630 pF1KE0 IVHILSGKCMEAVVQENNKDLY--LRPCDGKARQQWRFDQINAVDER . : : ::..:. .:.. .. :: : .. .:.: : . NP_078 LFHEQSKKCVQAARKESSDSFVPLLRDCTNSDHQKWFFKERML 540 550 560 570 580 >>XP_016870622 (OMIM: 608812,610290) PREDICTED: polypept (497 aa) initn: 1172 init1: 558 opt: 1306 Z-score: 1431.9 bits: 274.8 E(85289): 5.1e-73 Smith-Waterman score: 1306; 44.6% identity (72.0% similar) in 460 aa overlap (183-632:44-494) 160 170 180 190 200 210 pF1KE0 SLDPRGLQEALSARIPLQRALPEVRHPLCLQQHPQDSLPTASVILCFHDEAWSTLLRTVH ... :.:: .:::. :..::::::::::. XP_016 HLENIRVAFFLESVLQYFKSTEHVQFRCKEKKYDYDNLPRTSVIIAFYNEAWSTLLRTVY 20 30 40 50 60 70 220 230 240 250 260 270 pF1KE0 SILDTVPRAFLKEIILVDDLSQQGQLKSALSEYVARLEGVKLLRSNKRLGAIRARMLGAT :.:.: : .:.:.::::: :.. .:: :.. .. : :.:.:.::: : .:::.:::. XP_016 SVLETSPDILLEEVILVDDYSDREHLKERLANELSGLPKVRLIRANKREGLVRARLLGAS 80 90 100 110 120 130 280 290 300 310 320 330 pF1KE0 RATGDVLVFMDAHCECHPGWLEPLLSRIAGDRSRVVSPVIDVIDWKTFQYYP-SKDLQRG : ::::.:.: ::::: :::::::.:: ..: :: ::::::::.::.: : . : : XP_016 AARGDVLTFLDCHCECHEGWLEPLLQRIHEEESAVVCPVIDVIDWNTFEYLGNSGEPQIG 140 150 160 170 180 190 340 350 360 370 380 390 pF1KE0 VLDWKLDFHWEPLPEHVRKALQSPISPIRSPVVPGEVVAMDRHYFQNTGAYDSLMSLRGG .::.: : :. .::. : .:::.. ::::.. : . :....::. :.::. : . :: XP_016 GFDWRLVFTWHTVPERERIRMQSPVDVIRSPTMAGGLFAVSKKYFEYLGSYDTGMEVWGG 200 210 220 230 240 250 400 410 420 430 440 450 pF1KE0 ENLELSFKAWLCGGSVEILPCSRVGHIYQNQDSHSPLDQEATLRNRVRIAETWLGSFKET ::::.::. : ::: .: :::.:::.. .: .: ... .: : :: ::.:. ::: XP_016 ENLEFSFRIWQCGGVLETHPCSHVGHVFPKQ---APYSRNKALANSVRAAEVWMDEFKEL 260 270 280 290 300 310 460 470 480 490 500 510 pF1KE0 FYKHSPEAFSLSKAEK-PDCMERLQLQRRLGCRTFHWFLANVYPELYPSEPRPSFSGKLH .:...:.: . : : :: ::. .: :. :.::: .:::::. : ::.: : :. XP_016 YYHRNPRA----RLEPFGDVTERKQLRDKLQCKDFKWFLETVYPELHVPEDRPGFFGMLQ 320 330 340 350 360 520 530 540 550 560 pF1KE0 NTGL-GLCADCQA--EGDILGCPMVLAPCSDSRQQQYLQHTSRKEIHFGSPQ-HLCFAVR : :: : : . :..:.: ..: : :.:....::.:::.... : . :.::. XP_016 NKGLTDYCFDYNPPDENQIVGHQVILYLCHGMGQNQFFEYTSQKEIRYNTHQPEGCIAVE 370 380 390 400 410 420 570 580 590 600 610 620 pF1KE0 --QEQVILQNCTEEGLAIHQQHWDFQENGMIVHILSGKCMEAVVQENNKDLY--LRPCDG .. .:.. : : : ..:.. .::.: . : : ::..:. .:.. .. :: : . XP_016 AGMDTLIMHLCEET--APENQKFILQEDGSLFHEQSKKCVQAARKESSDSFVPLLRDCTN 430 440 450 460 470 480 630 pF1KE0 KARQQWRFDQINAVDER . .:.: : . XP_016 SDHQKWFFKERML 490 >>XP_011517320 (OMIM: 608812,610290) PREDICTED: polypept (507 aa) initn: 1172 init1: 558 opt: 1306 Z-score: 1431.7 bits: 274.8 E(85289): 5.2e-73 Smith-Waterman score: 1306; 44.6% identity (72.0% similar) in 460 aa overlap (183-632:54-504) 160 170 180 190 200 210 pF1KE0 SLDPRGLQEALSARIPLQRALPEVRHPLCLQQHPQDSLPTASVILCFHDEAWSTLLRTVH ... :.:: .:::. :..::::::::::. XP_011 HLENIRVAFFLESVLQYFKSTEHVQFRCKEKKYDYDNLPRTSVIIAFYNEAWSTLLRTVY 30 40 50 60 70 80 220 230 240 250 260 270 pF1KE0 SILDTVPRAFLKEIILVDDLSQQGQLKSALSEYVARLEGVKLLRSNKRLGAIRARMLGAT :.:.: : .:.:.::::: :.. .:: :.. .. : :.:.:.::: : .:::.:::. XP_011 SVLETSPDILLEEVILVDDYSDREHLKERLANELSGLPKVRLIRANKREGLVRARLLGAS 90 100 110 120 130 140 280 290 300 310 320 330 pF1KE0 RATGDVLVFMDAHCECHPGWLEPLLSRIAGDRSRVVSPVIDVIDWKTFQYYP-SKDLQRG : ::::.:.: ::::: :::::::.:: ..: :: ::::::::.::.: : . : : XP_011 AARGDVLTFLDCHCECHEGWLEPLLQRIHEEESAVVCPVIDVIDWNTFEYLGNSGEPQIG 150 160 170 180 190 200 340 350 360 370 380 390 pF1KE0 VLDWKLDFHWEPLPEHVRKALQSPISPIRSPVVPGEVVAMDRHYFQNTGAYDSLMSLRGG .::.: : :. .::. : .:::.. ::::.. : . :....::. :.::. : . :: XP_011 GFDWRLVFTWHTVPERERIRMQSPVDVIRSPTMAGGLFAVSKKYFEYLGSYDTGMEVWGG 210 220 230 240 250 260 400 410 420 430 440 450 pF1KE0 ENLELSFKAWLCGGSVEILPCSRVGHIYQNQDSHSPLDQEATLRNRVRIAETWLGSFKET ::::.::. : ::: .: :::.:::.. .: .: ... .: : :: ::.:. ::: XP_011 ENLEFSFRIWQCGGVLETHPCSHVGHVFPKQ---APYSRNKALANSVRAAEVWMDEFKEL 270 280 290 300 310 320 460 470 480 490 500 510 pF1KE0 FYKHSPEAFSLSKAEK-PDCMERLQLQRRLGCRTFHWFLANVYPELYPSEPRPSFSGKLH .:...:.: . : : :: ::. .: :. :.::: .:::::. : ::.: : :. XP_011 YYHRNPRA----RLEPFGDVTERKQLRDKLQCKDFKWFLETVYPELHVPEDRPGFFGMLQ 330 340 350 360 370 520 530 540 550 560 pF1KE0 NTGL-GLCADCQA--EGDILGCPMVLAPCSDSRQQQYLQHTSRKEIHFGSPQ-HLCFAVR : :: : : . :..:.: ..: : :.:....::.:::.... : . :.::. XP_011 NKGLTDYCFDYNPPDENQIVGHQVILYLCHGMGQNQFFEYTSQKEIRYNTHQPEGCIAVE 380 390 400 410 420 430 570 580 590 600 610 620 pF1KE0 --QEQVILQNCTEEGLAIHQQHWDFQENGMIVHILSGKCMEAVVQENNKDLY--LRPCDG .. .:.. : : : ..:.. .::.: . : : ::..:. .:.. .. :: : . XP_011 AGMDTLIMHLCEET--APENQKFILQEDGSLFHEQSKKCVQAARKESSDSFVPLLRDCTN 440 450 460 470 480 490 630 pF1KE0 KARQQWRFDQINAVDER . .:.: : . XP_011 SDHQKWFFKERML 500 639 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 15:51:41 2016 done: Thu Nov 3 15:51:42 2016 Total Scan time: 9.250 Total Display time: 0.120 Function used was FASTA [36.3.4 Apr, 2011]