FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0329, 508 aa 1>>>pF1KE0329 508 - 508 aa - 508 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.6201+/-0.000417; mu= 5.4288+/- 0.026 mean_var=317.4879+/-64.226, 0's: 0 Z-trim(119.8): 15 B-trim: 0 in 0/59 Lambda= 0.071980 statistics sampled from 34190 (34205) to 34190 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.728), E-opt: 0.2 (0.401), width: 16 Scan time: 11.790 The best scores are: opt bits E(85289) NP_055422 (OMIM: 611216) UBX domain-containing pro ( 508) 3263 352.8 1.3e-96 XP_016873363 (OMIM: 616378) PREDICTED: UBX domain- ( 297) 361 51.2 5e-06 NP_001273006 (OMIM: 616378) UBX domain-containing ( 297) 361 51.2 5e-06 NP_001273007 (OMIM: 616378) UBX domain-containing ( 238) 338 48.7 2.3e-05 XP_005274090 (OMIM: 616378) PREDICTED: UBX domain- ( 312) 340 49.0 2.4e-05 NP_056937 (OMIM: 616378) UBX domain-containing pro ( 312) 340 49.0 2.4e-05 >>NP_055422 (OMIM: 611216) UBX domain-containing protein (508 aa) initn: 3263 init1: 3263 opt: 3263 Z-score: 1855.2 bits: 352.8 E(85289): 1.3e-96 Smith-Waterman score: 3263; 100.0% identity (100.0% similar) in 508 aa overlap (1-508:1-508) 10 20 30 40 50 60 pF1KE0 MLWFQGAIPAAIATAKRSGAVFVVFVAGDDEQSTQMAASWEDDKVTEASSNSFVAIKIDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MLWFQGAIPAAIATAKRSGAVFVVFVAGDDEQSTQMAASWEDDKVTEASSNSFVAIKIDT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 KSEACLQFSQIYPVVCVPSSFFIGDSGIPLEVIAGSVSADELVTRIHKVRQMHLLKSETS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 KSEACLQFSQIYPVVCVPSSFFIGDSGIPLEVIAGSVSADELVTRIHKVRQMHLLKSETS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 VANGSQSESSVSTPSASFEPNNTCENSQSRNAELCEIPPTSDTKSDTATGGESAGHATSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 VANGSQSESSVSTPSASFEPNNTCENSQSRNAELCEIPPTSDTKSDTATGGESAGHATSS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 QEPSGCSDQRPAEDLNIRVERLTKKLEERREEKRKEEEQREIKKEIERRKTGKEMLDYKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 QEPSGCSDQRPAEDLNIRVERLTKKLEERREEKRKEEEQREIKKEIERRKTGKEMLDYKR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 KQEEELTKRMLEERNREKAEDRAARERIKQQIALDRAERAARFAKTKEEVEAAKAAALLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 KQEEELTKRMLEERNREKAEDRAARERIKQQIALDRAERAARFAKTKEEVEAAKAAALLA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 KQAEMEVKRESYARERSTVARIQFRLPDGSSFTNQFPSDAPLEEARQFAAQTVGNTYGNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 KQAEMEVKRESYARERSTVARIQFRLPDGSSFTNQFPSDAPLEEARQFAAQTVGNTYGNF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 SLATMFPRREFTKEDYKKKLLDLELAPSASVVLLPAGRPTASIVHSSSGDIWTLLGTVLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 SLATMFPRREFTKEDYKKKLLDLELAPSASVVLLPAGRPTASIVHSSSGDIWTLLGTVLY 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE0 PFLAIWRLISNFLFSNPPPTQTSVRVTSSEPPNPASSSKSEKREPVRKRVLEKRGDDFKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 PFLAIWRLISNFLFSNPPPTQTSVRVTSSEPPNPASSSKSEKREPVRKRVLEKRGDDFKK 430 440 450 460 470 480 490 500 pF1KE0 EGKIYRLRTQDDGEDENNTWNGNSTQQM :::::::::::::::::::::::::::: NP_055 EGKIYRLRTQDDGEDENNTWNGNSTQQM 490 500 >>XP_016873363 (OMIM: 616378) PREDICTED: UBX domain-cont (297 aa) initn: 354 init1: 218 opt: 361 Z-score: 229.1 bits: 51.2 E(85289): 5e-06 Smith-Waterman score: 363; 31.8% identity (59.2% similar) in 255 aa overlap (156-393:43-291) 130 140 150 160 170 180 pF1KE0 QSESSVSTPSASFEPNNTCENSQSRNAELCEIPPTSDTKSDTATGGESAGHATSSQ---- : : : .: : . . :::. XP_016 MGFPRGRAEKALALTGNQGIEAAMDWLMEHEDDPDVDEPLETPLGHILGREPTSSEQGGL 20 30 40 50 60 70 190 200 210 220 230 pF1KE0 EPSGCS--DQRPAEDLNIRVERLTKKLE--ERREEKRKEEEQRE-IKKEIERRKTGKEML : :: . . .:: . . : :. . :: .....:.:.:.:: ...: .::. :.:. XP_016 EGSGSAAGEGKPALSEEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELS 80 90 100 110 120 130 240 250 260 270 280 290 pF1KE0 DYKRKQEEELTKRMLEERNREKAEDRAARERIKQQIALDRAERAARFAKT----KEEVEA ... .:. .: ::: :::::. :::.:....: :.:::: ... . : XP_016 AARQRLQEDEMRRAAEERRREKAEELAARQRVREKIERDKAERAKKYGGSVGSQPPPVAP 140 150 160 170 180 190 300 310 320 330 340 350 pF1KE0 AKAAALLAKQAEMEVKRESYARERSTVARIQFRLPDGSSFTNQFPSDAPLEEARQFAAQT . . . . : .::: : . ::: :::::.:.:. : . : .: .. XP_016 EPGPVPSSPSQEPPTKRE-YDQ-----CRIQVRLPDGTSLTQTFRAREQLAAVRLYVELH 200 210 220 230 240 360 370 380 390 400 pF1KE0 VGNTYGN----FSLATMFPRREFTKEDYKKKLLDLELAPSASVVLLPAGRPTASIVHSSS :. :. .: . :::: :.. :... : .: :.::: ... XP_016 RGEELGGGQDPVQLLSGFPRRAFSEADMERPLQELGLVPSAVLIVAKKCPS 250 260 270 280 290 410 420 430 440 450 460 pF1KE0 GDIWTLLGTVLYPFLAIWRLISNFLFSNPPPTQTSVRVTSSEPPNPASSSKSEKREPVRK >>NP_001273006 (OMIM: 616378) UBX domain-containing prot (297 aa) initn: 354 init1: 218 opt: 361 Z-score: 229.1 bits: 51.2 E(85289): 5e-06 Smith-Waterman score: 363; 31.8% identity (59.2% similar) in 255 aa overlap (156-393:43-291) 130 140 150 160 170 180 pF1KE0 QSESSVSTPSASFEPNNTCENSQSRNAELCEIPPTSDTKSDTATGGESAGHATSSQ---- : : : .: : . . :::. NP_001 MGFPRGRAEKALALTGNQGIEAAMDWLMEHEDDPDVDEPLETPLGHILGREPTSSEQGGL 20 30 40 50 60 70 190 200 210 220 230 pF1KE0 EPSGCS--DQRPAEDLNIRVERLTKKLE--ERREEKRKEEEQRE-IKKEIERRKTGKEML : :: . . .:: . . : :. . :: .....:.:.:.:: ...: .::. :.:. NP_001 EGSGSAAGEGKPALSEEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELS 80 90 100 110 120 130 240 250 260 270 280 290 pF1KE0 DYKRKQEEELTKRMLEERNREKAEDRAARERIKQQIALDRAERAARFAKT----KEEVEA ... .:. .: ::: :::::. :::.:....: :.:::: ... . : NP_001 AARQRLQEDEMRRAAEERRREKAEELAARQRVREKIERDKAERAKKYGGSVGSQPPPVAP 140 150 160 170 180 190 300 310 320 330 340 350 pF1KE0 AKAAALLAKQAEMEVKRESYARERSTVARIQFRLPDGSSFTNQFPSDAPLEEARQFAAQT . . . . : .::: : . ::: :::::.:.:. : . : .: .. NP_001 EPGPVPSSPSQEPPTKRE-YDQ-----CRIQVRLPDGTSLTQTFRAREQLAAVRLYVELH 200 210 220 230 240 360 370 380 390 400 pF1KE0 VGNTYGN----FSLATMFPRREFTKEDYKKKLLDLELAPSASVVLLPAGRPTASIVHSSS :. :. .: . :::: :.. :... : .: :.::: ... NP_001 RGEELGGGQDPVQLLSGFPRRAFSEADMERPLQELGLVPSAVLIVAKKCPS 250 260 270 280 290 410 420 430 440 450 460 pF1KE0 GDIWTLLGTVLYPFLAIWRLISNFLFSNPPPTQTSVRVTSSEPPNPASSSKSEKREPVRK >>NP_001273007 (OMIM: 616378) UBX domain-containing prot (238 aa) initn: 345 init1: 209 opt: 338 Z-score: 217.3 bits: 48.7 E(85289): 2.3e-05 Smith-Waterman score: 338; 32.8% identity (63.1% similar) in 198 aa overlap (205-393:41-232) 180 190 200 210 220 230 pF1KE0 GHATSSQEPSGCSDQRPAEDLNIRVERLTKKLEERREEKRKEEEQRE-IKKEIERRKTGK .: .....:.:.:.:: ...: .::. :. NP_001 IEMGFPRGRAEKALALTGNQGIEAAMDWMLELVAQKQREREEREEREALERERQRRRQGQ 20 30 40 50 60 70 240 250 260 270 280 pF1KE0 EMLDYKRKQEEELTKRMLEERNREKAEDRAARERIKQQIALDRAERAARFAKT----KEE :. ... .:. .: ::: :::::. :::.:....: :.:::: ... . NP_001 ELSAARQRLQEDEMRRAAEERRREKAEELAARQRVREKIERDKAERAKKYGGSVGSQPPP 80 90 100 110 120 130 290 300 310 320 330 340 pF1KE0 VEAAKAAALLAKQAEMEVKRESYARERSTVARIQFRLPDGSSFTNQFPSDAPLEEARQFA : . . . . : .::: : . ::: :::::.:.:. : . : .: .. NP_001 VAPEPGPVPSSPSQEPPTKRE-YDQ-----CRIQVRLPDGTSLTQTFRAREQLAAVRLYV 140 150 160 170 180 350 360 370 380 390 400 pF1KE0 AQTVGNTYGN----FSLATMFPRREFTKEDYKKKLLDLELAPSASVVLLPAGRPTASIVH :. :. .: . :::: :.. :... : .: :.::: ... NP_001 ELHRGEELGGGQDPVQLLSGFPRRAFSEADMERPLQELGLVPSAVLIVAKKCPS 190 200 210 220 230 410 420 430 440 450 460 pF1KE0 SSSGDIWTLLGTVLYPFLAIWRLISNFLFSNPPPTQTSVRVTSSEPPNPASSSKSEKREP >>XP_005274090 (OMIM: 616378) PREDICTED: UBX domain-cont (312 aa) initn: 280 init1: 218 opt: 340 Z-score: 217.1 bits: 49.0 E(85289): 2.4e-05 Smith-Waterman score: 342; 31.5% identity (58.5% similar) in 248 aa overlap (156-386:43-284) 130 140 150 160 170 180 pF1KE0 QSESSVSTPSASFEPNNTCENSQSRNAELCEIPPTSDTKSDTATGGESAGHATSSQ---- : : : .: : . . :::. XP_005 MGFPRGRAEKALALTGNQGIEAAMDWLMEHEDDPDVDEPLETPLGHILGREPTSSEQGGL 20 30 40 50 60 70 190 200 210 220 230 pF1KE0 EPSGCS--DQRPAEDLNIRVERLTKKLE--ERREEKRKEEEQRE-IKKEIERRKTGKEML : :: . . .:: . . : :. . :: .....:.:.:.:: ...: .::. :.:. XP_005 EGSGSAAGEGKPALSEEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELS 80 90 100 110 120 130 240 250 260 270 280 290 pF1KE0 DYKRKQEEELTKRMLEERNREKAEDRAARERIKQQIALDRAERAARFAKT----KEEVEA ... .:. .: ::: :::::. :::.:....: :.:::: ... . : XP_005 AARQRLQEDEMRRAAEERRREKAEELAARQRVREKIERDKAERAKKYGGSVGSQPPPVAP 140 150 160 170 180 190 300 310 320 330 340 350 pF1KE0 AKAAALLAKQAEMEVKRESYARERSTVARIQFRLPDGSSFTNQFPSDAPLEEARQFAAQT . . . . : .::: : . ::: :::::.:.:. : . : .: .. XP_005 EPGPVPSSPSQEPPTKRE-YDQ-----CRIQVRLPDGTSLTQTFRAREQLAAVRLYVELH 200 210 220 230 240 360 370 380 390 400 pF1KE0 VGNTYGN----FSLATMFPRREFTKEDYKKKLLDLELAPSASVVLLPAGRPTASIVHSSS :. :. .: . :::: :.. :... : .: .: XP_005 RGEELGGGQDPVQLLSGFPRRAFSEADMERPLQELGMAARLETRTRNWGSREACLGKGGM 250 260 270 280 290 300 410 420 430 440 450 460 pF1KE0 GDIWTLLGTVLYPFLAIWRLISNFLFSNPPPTQTSVRVTSSEPPNPASSSKSEKREPVRK XP_005 QREGAL 310 >>NP_056937 (OMIM: 616378) UBX domain-containing protein (312 aa) initn: 280 init1: 218 opt: 340 Z-score: 217.1 bits: 49.0 E(85289): 2.4e-05 Smith-Waterman score: 342; 31.5% identity (58.5% similar) in 248 aa overlap (156-386:43-284) 130 140 150 160 170 180 pF1KE0 QSESSVSTPSASFEPNNTCENSQSRNAELCEIPPTSDTKSDTATGGESAGHATSSQ---- : : : .: : . . :::. NP_056 MGFPRGRAEKALALTGNQGIEAAMDWLMEHEDDPDVDEPLETPLGHILGREPTSSEQGGL 20 30 40 50 60 70 190 200 210 220 230 pF1KE0 EPSGCS--DQRPAEDLNIRVERLTKKLE--ERREEKRKEEEQRE-IKKEIERRKTGKEML : :: . . .:: . . : :. . :: .....:.:.:.:: ...: .::. :.:. NP_056 EGSGSAAGEGKPALSEEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELS 80 90 100 110 120 130 240 250 260 270 280 290 pF1KE0 DYKRKQEEELTKRMLEERNREKAEDRAARERIKQQIALDRAERAARFAKT----KEEVEA ... .:. .: ::: :::::. :::.:....: :.:::: ... . : NP_056 AARQRLQEDEMRRAAEERRREKAEELAARQRVREKIERDKAERAKKYGGSVGSQPPPVAP 140 150 160 170 180 190 300 310 320 330 340 350 pF1KE0 AKAAALLAKQAEMEVKRESYARERSTVARIQFRLPDGSSFTNQFPSDAPLEEARQFAAQT . . . . : .::: : . ::: :::::.:.:. : . : .: .. NP_056 EPGPVPSSPSQEPPTKRE-YDQ-----CRIQVRLPDGTSLTQTFRAREQLAAVRLYVELH 200 210 220 230 240 360 370 380 390 400 pF1KE0 VGNTYGN----FSLATMFPRREFTKEDYKKKLLDLELAPSASVVLLPAGRPTASIVHSSS :. :. .: . :::: :.. :... : .: .: NP_056 RGEELGGGQDPVQLLSGFPRRAFSEADMERPLQELGMAARLETRTRNWGSREACLGKGGM 250 260 270 280 290 300 410 420 430 440 450 460 pF1KE0 GDIWTLLGTVLYPFLAIWRLISNFLFSNPPPTQTSVRVTSSEPPNPASSSKSEKREPVRK NP_056 QREGAL 310 508 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 15:45:26 2016 done: Thu Nov 3 15:45:28 2016 Total Scan time: 11.790 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]