FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0340, 507 aa 1>>>pF1KE0340 507 - 507 aa - 507 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.3951+/-0.000823; mu= 18.4953+/- 0.049 mean_var=76.5985+/-15.244, 0's: 0 Z-trim(107.4): 14 B-trim: 0 in 0/54 Lambda= 0.146543 statistics sampled from 9567 (9576) to 9567 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.665), E-opt: 0.2 (0.294), width: 16 Scan time: 3.250 The best scores are: opt bits E(32554) CCDS14007.1 XPNPEP3 gene_id:63929|Hs108|chr22 ( 507) 3450 738.9 3e-213 CCDS42544.1 PEPD gene_id:5184|Hs108|chr19 ( 493) 464 107.6 3.2e-23 CCDS54244.1 PEPD gene_id:5184|Hs108|chr19 ( 429) 376 89.0 1.1e-17 CCDS54245.1 PEPD gene_id:5184|Hs108|chr19 ( 452) 316 76.3 7.9e-14 >>CCDS14007.1 XPNPEP3 gene_id:63929|Hs108|chr22 (507 aa) initn: 3450 init1: 3450 opt: 3450 Z-score: 3941.9 bits: 738.9 E(32554): 3e-213 Smith-Waterman score: 3450; 100.0% identity (100.0% similar) in 507 aa overlap (1-507:1-507) 10 20 30 40 50 60 pF1KE0 MPWLLSAPKLVPAVANVRGLSGCMLCSQRRYSLQPVPERRIPNRYLGQPSPFTHPHLLRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 MPWLLSAPKLVPAVANVRGLSGCMLCSQRRYSLQPVPERRIPNRYLGQPSPFTHPHLLRP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 GEVTPGLSQVEYALRRHKLMSLIQKEAQGQSGTDQTVVVLSNPTYYMSNDIPYTFHQDNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 GEVTPGLSQVEYALRRHKLMSLIQKEAQGQSGTDQTVVVLSNPTYYMSNDIPYTFHQDNN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 FLYLCGFQEPDSILVLQSLPGKQLPSHKAILFVPRRDPSRELWDGPRSGTDGAIALTGVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 FLYLCGFQEPDSILVLQSLPGKQLPSHKAILFVPRRDPSRELWDGPRSGTDGAIALTGVD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 EAYTLEEFQHLLPKMKAETNMVWYDWMRPSHAQLHSDYMQPLTEAKAKSKNKVRGVQQLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 EAYTLEEFQHLLPKMKAETNMVWYDWMRPSHAQLHSDYMQPLTEAKAKSKNKVRGVQQLI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 QRLRLIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRARGADILAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 QRLRLIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECRARGADILAY 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 PPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTAPQAEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 PPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRFTAPQAEL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 YEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKNIKENNAFKAARKYCPH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 YEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKNIKENNAFKAARKYCPH 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE0 HVGHYLGMDVHDTPDMPRSLPLQPGMVITIEPGIYIPEDDKDAPEKFRGLGVRIEDDVVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 HVGHYLGMDVHDTPDMPRSLPLQPGMVITIEPGIYIPEDDKDAPEKFRGLGVRIEDDVVV 430 440 450 460 470 480 490 500 pF1KE0 TQDSPLILSADCPKEMNDIEQICSQAS ::::::::::::::::::::::::::: CCDS14 TQDSPLILSADCPKEMNDIEQICSQAS 490 500 >>CCDS42544.1 PEPD gene_id:5184|Hs108|chr19 (493 aa) initn: 383 init1: 130 opt: 464 Z-score: 530.3 bits: 107.6 E(32554): 3.2e-23 Smith-Waterman score: 572; 29.3% identity (57.1% similar) in 468 aa overlap (72-500:23-476) 50 60 70 80 90 100 pF1KE0 PNRYLGQPSPFTHPHLLRPGEVTPGLSQVEYALRRHKLMSLIQKEAQGQSGTDQTVVVLS .:: :..: ..:. :.:. .:::. CCDS42 MAAATGPSFWLGNETLKVPLALFALNRQRLCERLRKNPAVQAGS---IVVLQ 10 20 30 40 110 120 130 140 150 pF1KE0 N--PTYYMSNDIPYTFHQDNNFLYLCGFQEPDSILVLQSLPGKQLPSHKAILFVPRRDPS . : . .: :.:.. : . : :: :.. :: . ::::: : CCDS42 GGEETQRYCTDTGVLFRQESFFHWAFGVTEPGCYGVIDVDTGK------STLFVPRLPAS 50 60 70 80 90 100 160 170 180 190 200 210 pF1KE0 RELWDGPRSGTDGAIALTGVDEAYTLEEFQHLLPKMKAETNMVWYDWMRPSHAQLHSDYM . : : . . .::.. ..:. .: ..: . .. .: ... : CCDS42 HATWMGKIHSKEHFKEKYAVDDVQYVDEIASVLTSQKPSVLLT----LRGVNTDSGSVCR 110 120 130 140 150 220 230 240 250 260 270 pF1KE0 QPLTEAKAKSKNKVRGVQQLIQRLRLIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEE . .. .: . . .. : . :..:. :.: .. ..:..:.: :.: . :. ..: CCDS42 EASFDGISKFEVNNTILHPEIVECRVFKTDMELEVLRYTNKISSEAHREVMKAVKVGMKE 160 170 180 190 200 210 280 290 300 310 320 330 pF1KE0 AFLYAKFEFECRARGA-DILAYPPVVAGGNRSNTLHY----VKNNQLIKDGEMVLLDGGC : . :: : .::. .: . ..:. : .::: . :.. :..:.: :.: : CCDS42 YELESLFEHYCYSRGGMRHSSYTCICGSGENSAVLHYGHAGAPNDRTIQNGDMCLFDMGG 220 230 240 250 260 270 340 350 360 370 380 390 pF1KE0 ESSCYVSDITRTWPVNGRFTAPQAELYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQ : :..:::: ..:.::.::: : .:::::. .: .. ::. ... . . . CCDS42 EYYCFASDITCSFPANGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLADRIHLE 280 290 300 310 320 330 400 410 420 430 440 pF1KE0 KLKDLGIMK-NIKENNAFKAARKYCPHHVGHYLGMDVHDTPDMP-----------RSL-- .: .::.. .. . . . :: .::.::.::::. .: ::: CCDS42 ELAHMGILSGSVDAMVQAHLGAVFMPHGLGHFLGIDVHDVGGYPEGVERIDEPGLRSLRT 340 350 360 370 380 390 450 460 470 480 pF1KE0 --PLQPGMVITIEPGIYIPED---------------DKDAPEKFRGLG-VRIEDDVVVTQ ::::::.:.:::::. . .... ..:::.: ::::.::::: CCDS42 ARHLQPGMVLTVEPGIYFIDHLLDEALADPARASFLNREVLQRFRGFGGVRIEEDVVVT- 400 410 420 430 440 450 490 500 pF1KE0 DSPLILSADCPKEMNDIEQICSQAS :: . : . :. ...:: CCDS42 DSGIELLTCVPRTVEEIEACMAGCDKAFTPFSGPK 460 470 480 490 >>CCDS54244.1 PEPD gene_id:5184|Hs108|chr19 (429 aa) initn: 339 init1: 130 opt: 376 Z-score: 430.7 bits: 89.0 E(32554): 1.1e-17 Smith-Waterman score: 484; 33.7% identity (61.6% similar) in 294 aa overlap (244-500:120-412) 220 230 240 250 260 270 pF1KE0 LHSDYMQPLTEAKAKSKNKVRGVQQLIQRLRLIKSPAEIERMQIAGKLTSQAFIETMFTS :..:. :.: .. ..:..:.: :.: . CCDS54 SGSVCREASFDGISKFEVNNTILHPEIVECRVFKTDMELEVLRYTNKISSEAHREVMKAV 90 100 110 120 130 140 280 290 300 310 320 pF1KE0 KAPVEEAFLYAKFEFECRARGA-DILAYPPVVAGGNRSNTLHY----VKNNQLIKDGEMV :. ..: : . :: : .::. .: . ..:. : .::: . :.. :..:.: CCDS54 KVGMKEYELESLFEHYCYSRGGMRHSSYTCICGSGENSAVLHYGHAGAPNDRTIQNGDMC 150 160 170 180 190 200 330 340 350 360 370 380 pF1KE0 LLDGGCESSCYVSDITRTWPVNGRFTAPQAELYEAVLEIQRDCLALCFPGTSLENIYSMM :.: : : :..:::: ..:.::.::: : .:::::. .: .. ::. ... . CCDS54 LFDMGGEYYCFASDITCSFPANGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLA 210 220 230 240 250 260 390 400 410 420 430 pF1KE0 LTLIGQKLKDLGIMK-NIKENNAFKAARKYCPHHVGHYLGMDVHDTPDMP---------- . ..: .::.. .. . . . :: .::.::.::::. .: CCDS54 DRIHLEELAHMGILSGSVDAMVQAHLGAVFMPHGLGHFLGIDVHDVGGYPEGVERIDEPG 270 280 290 300 310 320 440 450 460 470 pF1KE0 -RSL----PLQPGMVITIEPGIYIPED---------------DKDAPEKFRGLG-VRIED ::: ::::::.:.:::::. . .... ..:::.: ::::. CCDS54 LRSLRTARHLQPGMVLTVEPGIYFIDHLLDEALADPARASFLNREVLQRFRGFGGVRIEE 330 340 350 360 370 380 480 490 500 pF1KE0 DVVVTQDSPLILSADCPKEMNDIEQICSQAS ::::: :: . : . :. ...:: CCDS54 DVVVT-DSGIELLTCVPRTVEEIEACMAGCDKAFTPFSGPK 390 400 410 420 >>CCDS54245.1 PEPD gene_id:5184|Hs108|chr19 (452 aa) initn: 383 init1: 130 opt: 316 Z-score: 361.8 bits: 76.3 E(32554): 7.9e-14 Smith-Waterman score: 453; 27.6% identity (51.5% similar) in 468 aa overlap (72-500:23-435) 50 60 70 80 90 100 pF1KE0 PNRYLGQPSPFTHPHLLRPGEVTPGLSQVEYALRRHKLMSLIQKEAQGQSGTDQTVVVLS .:: :..: ..:. :.:. .:::. CCDS54 MAAATGPSFWLGNETLKVPLALFALNRQRLCERLRKNPAVQAGS---IVVLQ 10 20 30 40 110 120 130 140 150 pF1KE0 N--PTYYMSNDIPYTFHQDNNFLYLCGFQEPDSILVLQSLPGKQLPSHKAILFVPRRDPS . : . .: :.:.. : . : :: :.. :: . ::::: : CCDS54 GGEETQRYCTDTGVLFRQESFFHWAFGVTEPGCYGVIDVDTGK------STLFVPRLPAS 50 60 70 80 90 100 160 170 180 190 200 210 pF1KE0 RELWDGPRSGTDGAIALTGVDEAYTLEEFQHLLPKMKAETNMVWYDWMRPSHAQLHSDYM . : : . . .::.. ..:. .: ..: :: . CCDS54 HATWMGKIHSKEHFKEKYAVDDVQYVDEIASVLTSQK------------PS-------VL 110 120 130 140 220 230 240 250 260 270 pF1KE0 QPLTEAKAKSKNKVRGVQQLIQRLRLIKSPAEIERMQIAGKLTSQAFIETMFTSKAPVEE : ... : . : . : : .... . . ..: . CCDS54 LTLRGVNTDSGSVCREA-----------SFDGISKFEVNNTILHPEIVECL--------- 150 160 170 180 280 290 300 310 320 330 pF1KE0 AFLYAKFEFECRARGA-DILAYPPVVAGGNRSNTLHY----VKNNQLIKDGEMVLLDGGC :: : .::. .: . ..:. : .::: . :.. :..:.: :.: : CCDS54 ------FEHYCYSRGGMRHSSYTCICGSGENSAVLHYGHAGAPNDRTIQNGDMCLFDMGG 190 200 210 220 230 340 350 360 370 380 390 pF1KE0 ESSCYVSDITRTWPVNGRFTAPQAELYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQ : :..:::: ..:.::.::: : .:::::. .: .. ::. ... . . . CCDS54 EYYCFASDITCSFPANGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLADRIHLE 240 250 260 270 280 290 400 410 420 430 440 pF1KE0 KLKDLGIMK-NIKENNAFKAARKYCPHHVGHYLGMDVHDTPDMP-----------RSL-- .: .::.. .. . . . :: .::.::.::::. .: ::: CCDS54 ELAHMGILSGSVDAMVQAHLGAVFMPHGLGHFLGIDVHDVGGYPEGVERIDEPGLRSLRT 300 310 320 330 340 350 450 460 470 480 pF1KE0 --PLQPGMVITIEPGIYIPED---------------DKDAPEKFRGLG-VRIEDDVVVTQ ::::::.:.:::::. . .... ..:::.: ::::.::::: CCDS54 ARHLQPGMVLTVEPGIYFIDHLLDEALADPARASFLNREVLQRFRGFGGVRIEEDVVVT- 360 370 380 390 400 410 490 500 pF1KE0 DSPLILSADCPKEMNDIEQICSQAS :: . : . :. ...:: CCDS54 DSGIELLTCVPRTVEEIEACMAGCDKAFTPFSGPK 420 430 440 450 507 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 15:13:11 2016 done: Thu Nov 3 15:13:11 2016 Total Scan time: 3.250 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]