FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0342, 625 aa 1>>>pF1KE0342 625 - 625 aa - 625 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.2279+/-0.0007; mu= 16.5631+/- 0.043 mean_var=102.0471+/-20.380, 0's: 0 Z-trim(112.8): 27 B-trim: 5 in 1/52 Lambda= 0.126962 statistics sampled from 13467 (13484) to 13467 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.749), E-opt: 0.2 (0.414), width: 16 Scan time: 3.940 The best scores are: opt bits E(32554) CCDS13774.1 TRMT2A gene_id:27037|Hs108|chr22 ( 625) 4263 791.1 0 CCDS58793.1 TRMT2A gene_id:27037|Hs108|chr22 ( 562) 3718 691.3 9.1e-199 CCDS82693.1 TRMT2A gene_id:27037|Hs108|chr22 ( 643) 3085 575.4 8.1e-164 CCDS14477.1 TRMT2B gene_id:79979|Hs108|chrX ( 504) 1063 204.9 2.1e-52 CCDS55464.1 TRMT2B gene_id:79979|Hs108|chrX ( 459) 943 182.9 8e-46 >>CCDS13774.1 TRMT2A gene_id:27037|Hs108|chr22 (625 aa) initn: 4263 init1: 4263 opt: 4263 Z-score: 4220.8 bits: 791.1 E(32554): 0 Smith-Waterman score: 4263; 100.0% identity (100.0% similar) in 625 aa overlap (1-625:1-625) 10 20 30 40 50 60 pF1KE0 MSENLDNEGPKPMESCGQESSSALSCPTVSVPPAAPAALEEVEKEGAGAATGPGPQPGLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 MSENLDNEGPKPMESCGQESSSALSCPTVSVPPAAPAALEEVEKEGAGAATGPGPQPGLY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 SYIRDDLFTSEIFKLELQNVPRHASFSDVRRFLGRFGLQPHKTKLFGQPPCAFVTFRSAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 SYIRDDLFTSEIFKLELQNVPRHASFSDVRRFLGRFGLQPHKTKLFGQPPCAFVTFRSAA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 ERDKALRVLHGALWKGRPLSVRLARPKADPMARRRRQEGESEPPVTRVADVVTPLWTVPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 ERDKALRVLHGALWKGRPLSVRLARPKADPMARRRRQEGESEPPVTRVADVVTPLWTVPY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 AEQLERKQLECEQVLQKLAKEIGSTNRALLPWLLEQRHKHNKACCPLEGVRPSPQQTEYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 AEQLERKQLECEQVLQKLAKEIGSTNRALLPWLLEQRHKHNKACCPLEGVRPSPQQTEYR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 NKCEFLVGVGVDGEDNTVGCRLGKYKGGTCAVAAPFDTVHIPEATKQVVKAFQEFIRSTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 NKCEFLVGVGVDGEDNTVGCRLGKYKGGTCAVAAPFDTVHIPEATKQVVKAFQEFIRSTP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 YSAYDPETYTGHWKQLTVRTSRRHQAMAIAYFHPQKLSPEELAELKTSLAQHFTAGPGRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 YSAYDPETYTGHWKQLTVRTSRRHQAMAIAYFHPQKLSPEELAELKTSLAQHFTAGPGRA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 SGVTCLYFVEEGQRKTPSQEGLPLEHVAGDRCIHEDLLGLTFRISPHAFFQVNTPAAEVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 SGVTCLYFVEEGQRKTPSQEGLPLEHVAGDRCIHEDLLGLTFRISPHAFFQVNTPAAEVL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE0 YTVIQDWAQLDAGSMVLDVCCGTGTIGLALARKVKRVIGVELCPEAVEDARVNAQDNELS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 YTVIQDWAQLDAGSMVLDVCCGTGTIGLALARKVKRVIGVELCPEAVEDARVNAQDNELS 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE0 NVEFHCGRAEDLVPTLVSRLASQHLVAILDPPRAGLHSKVILAIRRAKNLRRLLYVSCNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 NVEFHCGRAEDLVPTLVSRLASQHLVAILDPPRAGLHSKVILAIRRAKNLRRLLYVSCNP 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE0 RAAMGNFVDLCRAPSNRVKGIPFRPVKAVAVDLFPQTPHCEMLILFERVEHPNGTGVLGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 RAAMGNFVDLCRAPSNRVKGIPFRPVKAVAVDLFPQTPHCEMLILFERVEHPNGTGVLGP 550 560 570 580 590 600 610 620 pF1KE0 HSPPAQPTPGPPDNTLQETGTFPSS ::::::::::::::::::::::::: CCDS13 HSPPAQPTPGPPDNTLQETGTFPSS 610 620 >>CCDS58793.1 TRMT2A gene_id:27037|Hs108|chr22 (562 aa) initn: 3718 init1: 3718 opt: 3718 Z-score: 3682.0 bits: 691.3 E(32554): 9.1e-199 Smith-Waterman score: 3718; 100.0% identity (100.0% similar) in 549 aa overlap (1-549:1-549) 10 20 30 40 50 60 pF1KE0 MSENLDNEGPKPMESCGQESSSALSCPTVSVPPAAPAALEEVEKEGAGAATGPGPQPGLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 MSENLDNEGPKPMESCGQESSSALSCPTVSVPPAAPAALEEVEKEGAGAATGPGPQPGLY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 SYIRDDLFTSEIFKLELQNVPRHASFSDVRRFLGRFGLQPHKTKLFGQPPCAFVTFRSAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 SYIRDDLFTSEIFKLELQNVPRHASFSDVRRFLGRFGLQPHKTKLFGQPPCAFVTFRSAA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 ERDKALRVLHGALWKGRPLSVRLARPKADPMARRRRQEGESEPPVTRVADVVTPLWTVPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 ERDKALRVLHGALWKGRPLSVRLARPKADPMARRRRQEGESEPPVTRVADVVTPLWTVPY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 AEQLERKQLECEQVLQKLAKEIGSTNRALLPWLLEQRHKHNKACCPLEGVRPSPQQTEYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 AEQLERKQLECEQVLQKLAKEIGSTNRALLPWLLEQRHKHNKACCPLEGVRPSPQQTEYR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 NKCEFLVGVGVDGEDNTVGCRLGKYKGGTCAVAAPFDTVHIPEATKQVVKAFQEFIRSTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 NKCEFLVGVGVDGEDNTVGCRLGKYKGGTCAVAAPFDTVHIPEATKQVVKAFQEFIRSTP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 YSAYDPETYTGHWKQLTVRTSRRHQAMAIAYFHPQKLSPEELAELKTSLAQHFTAGPGRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 YSAYDPETYTGHWKQLTVRTSRRHQAMAIAYFHPQKLSPEELAELKTSLAQHFTAGPGRA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 SGVTCLYFVEEGQRKTPSQEGLPLEHVAGDRCIHEDLLGLTFRISPHAFFQVNTPAAEVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 SGVTCLYFVEEGQRKTPSQEGLPLEHVAGDRCIHEDLLGLTFRISPHAFFQVNTPAAEVL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE0 YTVIQDWAQLDAGSMVLDVCCGTGTIGLALARKVKRVIGVELCPEAVEDARVNAQDNELS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 YTVIQDWAQLDAGSMVLDVCCGTGTIGLALARKVKRVIGVELCPEAVEDARVNAQDNELS 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE0 NVEFHCGRAEDLVPTLVSRLASQHLVAILDPPRAGLHSKVILAIRRAKNLRRLLYVSCNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 NVEFHCGRAEDLVPTLVSRLASQHLVAILDPPRAGLHSKVILAIRRAKNLRRLLYVSCNP 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE0 RAAMGNFVDLCRAPSNRVKGIPFRPVKAVAVDLFPQTPHCEMLILFERVEHPNGTGVLGP ::::::::: CCDS58 RAAMGNFVDAPLFPPQPLQSPI 550 560 >>CCDS82693.1 TRMT2A gene_id:27037|Hs108|chr22 (643 aa) initn: 3085 init1: 3085 opt: 3085 Z-score: 3054.5 bits: 575.4 E(32554): 8.1e-164 Smith-Waterman score: 4217; 97.2% identity (97.2% similar) in 643 aa overlap (1-625:1-643) 10 20 30 40 50 60 pF1KE0 MSENLDNEGPKPMESCGQESSSALSCPTVSVPPAAPAALEEVEKEGAGAATGPGPQPGLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 MSENLDNEGPKPMESCGQESSSALSCPTVSVPPAAPAALEEVEKEGAGAATGPGPQPGLY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 SYIRDDLFTSEIFKLELQNVPRHASFSDVRRFLGRFGLQPHKTKLFGQPPCAFVTFRSAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 SYIRDDLFTSEIFKLELQNVPRHASFSDVRRFLGRFGLQPHKTKLFGQPPCAFVTFRSAA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 ERDKALRVLHGALWKGRPLSVRLARPKADPMARRRRQEGESEPPVTRVADVVTPLWTVPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 ERDKALRVLHGALWKGRPLSVRLARPKADPMARRRRQEGESEPPVTRVADVVTPLWTVPY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 AEQLERKQLECEQVLQKLAKEIGSTNRALLPWLLEQRHKHNKACCPLEGVRPSPQQTEYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 AEQLERKQLECEQVLQKLAKEIGSTNRALLPWLLEQRHKHNKACCPLEGVRPSPQQTEYR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 NKCEFLVGVGVDGEDNTVGCRLGKYKGGTCAVAAPFDTVHIPEATKQVVKAFQEFIRSTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 NKCEFLVGVGVDGEDNTVGCRLGKYKGGTCAVAAPFDTVHIPEATKQVVKAFQEFIRSTP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 YSAYDPETYTGHWKQLTVRTSRRHQAMAIAYFHPQKLSPEELAELKTSLAQHFTAGPGRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 YSAYDPETYTGHWKQLTVRTSRRHQAMAIAYFHPQKLSPEELAELKTSLAQHFTAGPGRA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 SGVTCLYFVEEGQRKTPSQEGLPLEHVAGDRCIHEDLLGLTFRISPHAFFQVNTPAAEVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 SGVTCLYFVEEGQRKTPSQEGLPLEHVAGDRCIHEDLLGLTFRISPHAFFQVNTPAAEVL 370 380 390 400 410 420 430 440 450 460 pF1KE0 YTVIQDWAQLDAGSMVLDVCCGTGTIGLALAR------------------KVKRVIGVEL :::::::::::::::::::::::::::::::: :::::::::: CCDS82 YTVIQDWAQLDAGSMVLDVCCGTGTIGLALARGPMYSPPWVGRHHAFLFQKVKRVIGVEL 430 440 450 460 470 480 470 480 490 500 510 520 pF1KE0 CPEAVEDARVNAQDNELSNVEFHCGRAEDLVPTLVSRLASQHLVAILDPPRAGLHSKVIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 CPEAVEDARVNAQDNELSNVEFHCGRAEDLVPTLVSRLASQHLVAILDPPRAGLHSKVIL 490 500 510 520 530 540 530 540 550 560 570 580 pF1KE0 AIRRAKNLRRLLYVSCNPRAAMGNFVDLCRAPSNRVKGIPFRPVKAVAVDLFPQTPHCEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 AIRRAKNLRRLLYVSCNPRAAMGNFVDLCRAPSNRVKGIPFRPVKAVAVDLFPQTPHCEM 550 560 570 580 590 600 590 600 610 620 pF1KE0 LILFERVEHPNGTGVLGPHSPPAQPTPGPPDNTLQETGTFPSS ::::::::::::::::::::::::::::::::::::::::::: CCDS82 LILFERVEHPNGTGVLGPHSPPAQPTPGPPDNTLQETGTFPSS 610 620 630 640 >>CCDS14477.1 TRMT2B gene_id:79979|Hs108|chrX (504 aa) initn: 573 init1: 371 opt: 1063 Z-score: 1054.4 bits: 204.9 E(32554): 2.1e-52 Smith-Waterman score: 1065; 37.3% identity (63.3% similar) in 520 aa overlap (77-588:1-504) 50 60 70 80 90 100 pF1KE0 AGAATGPGPQPGLYSYIRDDLFTSEIFKLELQNVPRHASFSDVRRFLGRFGL--QPHKTK . .. :.. . ..: :.. :: .: CCDS14 MAGLKRRVPLHSLRYFISMVGLFSKPGLLP 10 20 30 110 120 130 140 150 160 pF1KE0 LFGQ-PPCAFVTFRSAAERDKALRVLHGALWKGRPLSVRLARPKA-DPMARRRRQEGESE ... :: : ... . ::. ::. . .:. :. .: . CCDS14 WYARNPPGWSQLFLGTVCKGDFTRVIATKCQKGQKSQ---KKPSHLGPL------DGSWQ 40 50 60 70 80 170 180 190 200 210 220 pF1KE0 PPVTRVADVVTPLWTVPYAEQLERKQLECEQVLQKLAKEIGSTNRALLPWLLEQRHKHNK :.:::::::: . : :::. : ...::.: . : : . . . : .. CCDS14 E---RLADVVTPLWRLSYEEQLKVKFAAQKKILQRLESYIQMLNGVSVTTAVP---KSER 90 100 110 120 130 230 240 250 260 270 280 pF1KE0 ACCPLEGVRPSPQQTEYRNKCEFLVGVGVDGEDNTVGCRLGKYKGGTCAVAAPFDTVHIP : :. . ::: . :::: : :. : ::. .::: :: .. :. . . .:: CCDS14 LSCLLHPIIPSPVINGYRNKSTFSVNRGPDGNPKTVGFYLGTWRDGNVVCVQSNHLKNIP 140 150 160 170 180 190 290 300 310 320 330 340 pF1KE0 EATKQVVKAFQEFIRSTPYSAYDPETYTGHWKQLTVRTSRRHQAMAIAYFHPQKLSPEEL : .::.. .. :.:..: :.:..:::::. . ..::: ::::::: ::: CCDS14 EKHSQVAQYYEVFLRQSPLEPCLVFHEGGYWRELTVRTNSQGHTMAIITFHPQKLSQEEL 200 210 220 230 240 250 350 360 370 380 390 400 pF1KE0 AELKTSLAQHFTAGPGRASGVTCLYFVEEGQRKTPSQEGLPLEHVAGDRCIHEDLLGLTF : . . : ::: : :.: ::: : . . :.. : . . :. : :.::.: . CCDS14 HVQKEIVKEFFIRGPGAACGLTSLYFQESTMTRCSHQQS-PYQLLFGEPYIFEELLSLKI 260 270 280 290 300 310 410 420 430 440 450 460 pF1KE0 RISPHAFFQVNTPAAEVLYTVIQDWAQLDAGSMVLDVCCGTGTIGLALARKVKRVIGVEL :::: ::::.:: .::.:: .. . . ... ...::.:::::.:::.::....::.:.:: CCDS14 RISPDAFFQINTAGAEMLYRTVGELTGVNSDTILLDICCGTGVIGLSLAQHTSRVLGIEL 320 330 340 350 360 370 470 480 490 500 510 520 pF1KE0 CPEAVEDARVNAQDNELSNVEFHCGRAEDLVPTLV-SRLASQHLVAILDPPRAGLHSKVI .:::::: .: : ..: ::: :.:: ..: :. :. .: .::...: ::::: ::: CCDS14 LEQAVEDARWTAAFNGITNSEFHTGQAEKILPGLLKSKEDGQSIVAVVNPARAGLHYKVI 380 390 400 410 420 430 530 540 550 560 570 pF1KE0 LAIRRAKNLRRLLYVSCNPRA-AMGNFVDLCRAP--SNRVKGIPFRPVKAVAVDLFPQTP ::: . .. :..:::. .. . : ..:: : .... : :: .:: :::::.:: CCDS14 QAIRNFRAIHTLVFVSCKLHGESTRNVIELCCPPDPAKKLLGEPFVLQQAVPVDLFPHTP 440 450 460 470 480 490 580 590 600 610 620 pF1KE0 HCEMLILFERVEHPNGTGVLGPHSPPAQPTPGPPDNTLQETGTFPSS :::...:: : CCDS14 HCELVLLFTR 500 >>CCDS55464.1 TRMT2B gene_id:79979|Hs108|chrX (459 aa) initn: 529 init1: 349 opt: 943 Z-score: 936.2 bits: 182.9 E(32554): 8e-46 Smith-Waterman score: 943; 42.9% identity (69.1% similar) in 359 aa overlap (234-588:102-459) 210 220 230 240 250 260 pF1KE0 STNRALLPWLLEQRHKHNKACCPLEGVRPSPQQTEYRNKCEFLVGVGVDGEDNTVGCRLG : . :::: : :. : ::. .::: :: CCDS55 HLGPLDGSWQERLADVVTPLWRLSYEEQLKPVINGYRNKSTFSVNRGPDGNPKTVGFYLG 80 90 100 110 120 130 270 280 290 300 310 320 pF1KE0 KYKGGTCAVAAPFDTVHIPEATKQVVKAFQEFIRSTPYSAYDPETYTGHWKQLTVRTSRR .. :. . . .::: .::.. .. :.:..: :.:..:::::. . CCDS55 TWRDGNVVCVQSNHLKNIPEKHSQVAQYYEVFLRQSPLEPCLVFHEGGYWRELTVRTNSQ 140 150 160 170 180 190 330 340 350 360 370 380 pF1KE0 HQAMAIAYFHPQKLSPEELAELKTSLAQHFTAGPGRASGVTCLYFVEEGQRKTPSQEGLP ..::: ::::::: ::: : . . : ::: : :.: ::: : . . :.. : CCDS55 GHTMAIITFHPQKLSQEELHVQKEIVKEFFIRGPGAACGLTSLYFQESTMTRCSHQQS-P 200 210 220 230 240 250 390 400 410 420 430 440 pF1KE0 LEHVAGDRCIHEDLLGLTFRISPHAFFQVNTPAAEVLYTVIQDWAQLDAGSMVLDVCCGT . . :. : :.::.: .:::: ::::.:: .::.:: .. . . ... ...::.:::: CCDS55 YQLLFGEPYIFEELLSLKIRISPDAFFQINTAGAEMLYRTVGELTGVNSDTILLDICCGT 260 270 280 290 300 310 450 460 470 480 490 500 pF1KE0 GTIGLALARKVKRVIGVELCPEAVEDARVNAQDNELSNVEFHCGRAEDLVPTLV-SRLAS :.:::.::....::.:.:: .:::::: .: : ..: ::: :.:: ..: :. :. . CCDS55 GVIGLSLAQHTSRVLGIELLEQAVEDARWTAAFNGITNSEFHTGQAEKILPGLLKSKEDG 320 330 340 350 360 370 510 520 530 540 550 pF1KE0 QHLVAILDPPRAGLHSKVILAIRRAKNLRRLLYVSCNPRA-AMGNFVDLCRAP--SNRVK : .::...: ::::: ::: ::: . .. :..:::. .. . : ..:: : .... CCDS55 QSIVAVVNPARAGLHYKVIQAIRNFRAIHTLVFVSCKLHGESTRNVIELCCPPDPAKKLL 380 390 400 410 420 430 560 570 580 590 600 610 pF1KE0 GIPFRPVKAVAVDLFPQTPHCEMLILFERVEHPNGTGVLGPHSPPAQPTPGPPDNTLQET : :: .:: :::::.:::::...:: : CCDS55 GEPFVLQQAVPVDLFPHTPHCELVLLFTR 440 450 625 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 15:05:07 2016 done: Thu Nov 3 15:05:08 2016 Total Scan time: 3.940 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]