Result of FASTA (omim) for
pF1KE0351
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0351, 818 aa
1>>>pF1KE0351 818 - 818 aa - 818 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.3790+/-0.0004; mu= 14.7013+/- 0.025
mean_var=89.4179+/-18.050, 0's: 0 Z-trim(114.0): 201 B-trim: 321 in 1/53
Lambda= 0.135632
statistics sampled from 23413 (23650) to 23413 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.646), E-opt: 0.2 (0.277), width: 16
Scan time: 12.910
The best scores are: opt bits E(85289)
NP_828848 (OMIM: 612864) cytosolic phospholipase A ( 818) 5484 1083.9 0
XP_011519769 (OMIM: 612864) PREDICTED: cytosolic p ( 762) 5094 1007.5 0
NP_001108105 (OMIM: 606088) cytosolic phospholipas ( 781) 2086 419.0 4.1e-116
XP_011507944 (OMIM: 600522) PREDICTED: cytosolic p ( 749) 643 136.6 4e-31
NP_077734 (OMIM: 600522) cytosolic phospholipase A ( 749) 643 136.6 4e-31
XP_005245324 (OMIM: 600522) PREDICTED: cytosolic p ( 754) 643 136.6 4e-31
NP_001298122 (OMIM: 600522) cytosolic phospholipas ( 689) 582 124.6 1.5e-27
XP_016882900 (OMIM: 603602) PREDICTED: cytosolic p ( 509) 417 92.3 5.9e-18
XP_011525733 (OMIM: 603602) PREDICTED: cytosolic p ( 523) 417 92.3 6e-18
XP_016882903 (OMIM: 603602) PREDICTED: cytosolic p ( 282) 254 60.3 1.4e-08
NP_001152794 (OMIM: 603602) cytosolic phospholipas ( 551) 258 61.2 1.5e-08
XP_011525735 (OMIM: 603602) PREDICTED: cytosolic p ( 384) 254 60.3 1.8e-08
XP_011525734 (OMIM: 603602) PREDICTED: cytosolic p ( 445) 254 60.4 2.1e-08
NP_001152795 (OMIM: 603602) cytosolic phospholipas ( 527) 254 60.4 2.4e-08
NP_003697 (OMIM: 603602) cytosolic phospholipase A ( 541) 254 60.4 2.5e-08
XP_016882902 (OMIM: 603602) PREDICTED: cytosolic p ( 348) 248 59.1 3.8e-08
XP_016882901 (OMIM: 603602) PREDICTED: cytosolic p ( 362) 248 59.2 3.9e-08
NP_001153116 (OMIM: 616297) multiple C2 and transm ( 306) 174 44.6 0.00078
XP_016880330 (OMIM: 176960) PREDICTED: protein kin ( 324) 174 44.7 0.00082
XP_005255017 (OMIM: 616297) PREDICTED: multiple C2 ( 466) 174 44.7 0.0011
XP_011520077 (OMIM: 616297) PREDICTED: multiple C2 ( 506) 174 44.7 0.0012
XP_016880329 (OMIM: 176960) PREDICTED: protein kin ( 586) 174 44.8 0.0014
XP_016880328 (OMIM: 176960) PREDICTED: protein kin ( 586) 174 44.8 0.0014
XP_016880327 (OMIM: 176960) PREDICTED: protein kin ( 586) 174 44.8 0.0014
NP_001153801 (OMIM: 600327) synaptotagmin-3 [Homo ( 590) 174 44.8 0.0014
XP_011525693 (OMIM: 600327) PREDICTED: synaptotagm ( 590) 174 44.8 0.0014
NP_115674 (OMIM: 600327) synaptotagmin-3 [Homo sap ( 590) 174 44.8 0.0014
NP_001153800 (OMIM: 600327) synaptotagmin-3 [Homo ( 590) 174 44.8 0.0014
XP_011525692 (OMIM: 600327) PREDICTED: synaptotagm ( 590) 174 44.8 0.0014
XP_016880326 (OMIM: 176960) PREDICTED: protein kin ( 621) 174 44.8 0.0014
XP_016880325 (OMIM: 176960) PREDICTED: protein kin ( 645) 174 44.8 0.0015
NP_002728 (OMIM: 176960) protein kinase C alpha ty ( 672) 174 44.8 0.0015
NP_002730 (OMIM: 176980,605361) protein kinase C g ( 697) 174 44.8 0.0016
NP_001303258 (OMIM: 176980,605361) protein kinase ( 710) 174 44.8 0.0016
XP_016865354 (OMIM: 616296) PREDICTED: multiple C2 ( 537) 165 43.0 0.0043
XP_016862796 (OMIM: 616692) PREDICTED: extended sy ( 753) 167 43.4 0.0044
NP_001309763 (OMIM: 616692) extended synaptotagmin ( 874) 167 43.5 0.005
NP_001309760 (OMIM: 616692) extended synaptotagmin ( 886) 167 43.5 0.005
NP_114119 (OMIM: 616692) extended synaptotagmin-3 ( 886) 167 43.5 0.005
XP_016874523 (OMIM: 612159) PREDICTED: rabphilin-3 ( 346) 161 42.1 0.005
XP_011541952 (OMIM: 616296) PREDICTED: multiple C2 ( 660) 165 43.0 0.0051
XP_016865351 (OMIM: 616296) PREDICTED: multiple C2 ( 681) 165 43.0 0.0053
NP_001284706 (OMIM: 616296) multiple C2 and transm ( 692) 165 43.0 0.0053
XP_016865350 (OMIM: 616296) PREDICTED: multiple C2 ( 694) 165 43.0 0.0053
XP_016865353 (OMIM: 616296) PREDICTED: multiple C2 ( 694) 165 43.0 0.0053
XP_016865348 (OMIM: 616296) PREDICTED: multiple C2 ( 700) 165 43.0 0.0054
XP_016865347 (OMIM: 616296) PREDICTED: multiple C2 ( 701) 165 43.0 0.0054
XP_016865346 (OMIM: 616296) PREDICTED: multiple C2 ( 714) 165 43.0 0.0055
XP_016865352 (OMIM: 616296) PREDICTED: multiple C2 ( 719) 165 43.0 0.0055
XP_016865344 (OMIM: 616296) PREDICTED: multiple C2 ( 727) 165 43.1 0.0056
>>NP_828848 (OMIM: 612864) cytosolic phospholipase A2 de (818 aa)
initn: 5484 init1: 5484 opt: 5484 Z-score: 5798.6 bits: 1083.9 E(85289): 0
Smith-Waterman score: 5484; 100.0% identity (100.0% similar) in 818 aa overlap (1-818:1-818)
10 20 30 40 50 60
pF1KE0 MESLSPGGPPGHPYQGEASTCWQLTVRVLEARNLRWADLLSEADPYVILQLSTAPGMKFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_828 MESLSPGGPPGHPYQGEASTCWQLTVRVLEARNLRWADLLSEADPYVILQLSTAPGMKFK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 TKTLTDTSHPVWNEAFRFLIQSQVKNVLELSIYDEDSVTEDDICFKVLYDISEVLPGKLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_828 TKTLTDTSHPVWNEAFRFLIQSQVKNVLELSIYDEDSVTEDDICFKVLYDISEVLPGKLL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 RKTFSQSPQGEEELDVEFLMEETSDRPENLITNKVIVARELSCLDVHLDSTGSTAVVADQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_828 RKTFSQSPQGEEELDVEFLMEETSDRPENLITNKVIVARELSCLDVHLDSTGSTAVVADQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 DKLELELVLKGSYEDTQTSFLGTASAFRFHYMAALETELSGRLRSSRSNGWNGDNSAGYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_828 DKLELELVLKGSYEDTQTSFLGTASAFRFHYMAALETELSGRLRSSRSNGWNGDNSAGYL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 TVPLRPLTIGKEVTMDVPAPNAPGVRLQLKAEGCPEELAVHLGFNLCAEEQAFLSRRKQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_828 TVPLRPLTIGKEVTMDVPAPNAPGVRLQLKAEGCPEELAVHLGFNLCAEEQAFLSRRKQV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 VAKALKQALQLDRDLQEDEVPVVGIMATGGGARAMTSLYGHLLALQKLGLLDCVTYFSGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_828 VAKALKQALQLDRDLQEDEVPVVGIMATGGGARAMTSLYGHLLALQKLGLLDCVTYFSGI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 SGSTWTMAHLYGDPEWSQRDLEGPIRYAREHLAKSKLEVFSPERLASYRRELELRAEQGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_828 SGSTWTMAHLYGDPEWSQRDLEGPIRYAREHLAKSKLEVFSPERLASYRRELELRAEQGH
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE0 PTTFVDLWALVLESMLHGQVMDQKLSGQRAALERGQNPLPLYLSLNVKENNLETLDFKEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_828 PTTFVDLWALVLESMLHGQVMDQKLSGQRAALERGQNPLPLYLSLNVKENNLETLDFKEW
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE0 VEFSPYEVGFLKYGAFVPPELFGSEFFMGRLMRRIPEPRICFLEAIWSNIFSLNLLDAWY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_828 VEFSPYEVGFLKYGAFVPPELFGSEFFMGRLMRRIPEPRICFLEAIWSNIFSLNLLDAWY
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE0 DLTSSGESWKQHIKDKTRSLEKEPLTTSGTSSRLEASWLQPGTALAQAFKGFLTGRPLHQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_828 DLTSSGESWKQHIKDKTRSLEKEPLTTSGTSSRLEASWLQPGTALAQAFKGFLTGRPLHQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE0 RSPNFLQGLQLHQDYCSHKDFSTWADYQLDSMPSQLTPKEPRLCLVDAAYFINTSSPSMF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_828 RSPNFLQGLQLHQDYCSHKDFSTWADYQLDSMPSQLTPKEPRLCLVDAAYFINTSSPSMF
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE0 RPGRRLDLILSFDYSLSAPFEALQQTELYCRARGLPFPRVEPSPQDQHQPRECHLFSDPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_828 RPGRRLDLILSFDYSLSAPFEALQQTELYCRARGLPFPRVEPSPQDQHQPRECHLFSDPA
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE0 CPEAPILLHFPLVNASFKDHSAPGVQRSPAELQGGQVDLTGATCPYTLSNMTYKEEDFER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_828 CPEAPILLHFPLVNASFKDHSAPGVQRSPAELQGGQVDLTGATCPYTLSNMTYKEEDFER
730 740 750 760 770 780
790 800 810
pF1KE0 LLRLSDYNVQTSQGAILQALRTALKHRTLEARPPRAQT
::::::::::::::::::::::::::::::::::::::
NP_828 LLRLSDYNVQTSQGAILQALRTALKHRTLEARPPRAQT
790 800 810
>>XP_011519769 (OMIM: 612864) PREDICTED: cytosolic phosp (762 aa)
initn: 5094 init1: 5094 opt: 5094 Z-score: 5386.7 bits: 1007.5 E(85289): 0
Smith-Waterman score: 5094; 100.0% identity (100.0% similar) in 762 aa overlap (57-818:1-762)
30 40 50 60 70 80
pF1KE0 RVLEARNLRWADLLSEADPYVILQLSTAPGMKFKTKTLTDTSHPVWNEAFRFLIQSQVKN
::::::::::::::::::::::::::::::
XP_011 MKFKTKTLTDTSHPVWNEAFRFLIQSQVKN
10 20 30
90 100 110 120 130 140
pF1KE0 VLELSIYDEDSVTEDDICFKVLYDISEVLPGKLLRKTFSQSPQGEEELDVEFLMEETSDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLELSIYDEDSVTEDDICFKVLYDISEVLPGKLLRKTFSQSPQGEEELDVEFLMEETSDR
40 50 60 70 80 90
150 160 170 180 190 200
pF1KE0 PENLITNKVIVARELSCLDVHLDSTGSTAVVADQDKLELELVLKGSYEDTQTSFLGTASA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PENLITNKVIVARELSCLDVHLDSTGSTAVVADQDKLELELVLKGSYEDTQTSFLGTASA
100 110 120 130 140 150
210 220 230 240 250 260
pF1KE0 FRFHYMAALETELSGRLRSSRSNGWNGDNSAGYLTVPLRPLTIGKEVTMDVPAPNAPGVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FRFHYMAALETELSGRLRSSRSNGWNGDNSAGYLTVPLRPLTIGKEVTMDVPAPNAPGVR
160 170 180 190 200 210
270 280 290 300 310 320
pF1KE0 LQLKAEGCPEELAVHLGFNLCAEEQAFLSRRKQVVAKALKQALQLDRDLQEDEVPVVGIM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQLKAEGCPEELAVHLGFNLCAEEQAFLSRRKQVVAKALKQALQLDRDLQEDEVPVVGIM
220 230 240 250 260 270
330 340 350 360 370 380
pF1KE0 ATGGGARAMTSLYGHLLALQKLGLLDCVTYFSGISGSTWTMAHLYGDPEWSQRDLEGPIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ATGGGARAMTSLYGHLLALQKLGLLDCVTYFSGISGSTWTMAHLYGDPEWSQRDLEGPIR
280 290 300 310 320 330
390 400 410 420 430 440
pF1KE0 YAREHLAKSKLEVFSPERLASYRRELELRAEQGHPTTFVDLWALVLESMLHGQVMDQKLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YAREHLAKSKLEVFSPERLASYRRELELRAEQGHPTTFVDLWALVLESMLHGQVMDQKLS
340 350 360 370 380 390
450 460 470 480 490 500
pF1KE0 GQRAALERGQNPLPLYLSLNVKENNLETLDFKEWVEFSPYEVGFLKYGAFVPPELFGSEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GQRAALERGQNPLPLYLSLNVKENNLETLDFKEWVEFSPYEVGFLKYGAFVPPELFGSEF
400 410 420 430 440 450
510 520 530 540 550 560
pF1KE0 FMGRLMRRIPEPRICFLEAIWSNIFSLNLLDAWYDLTSSGESWKQHIKDKTRSLEKEPLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FMGRLMRRIPEPRICFLEAIWSNIFSLNLLDAWYDLTSSGESWKQHIKDKTRSLEKEPLT
460 470 480 490 500 510
570 580 590 600 610 620
pF1KE0 TSGTSSRLEASWLQPGTALAQAFKGFLTGRPLHQRSPNFLQGLQLHQDYCSHKDFSTWAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TSGTSSRLEASWLQPGTALAQAFKGFLTGRPLHQRSPNFLQGLQLHQDYCSHKDFSTWAD
520 530 540 550 560 570
630 640 650 660 670 680
pF1KE0 YQLDSMPSQLTPKEPRLCLVDAAYFINTSSPSMFRPGRRLDLILSFDYSLSAPFEALQQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YQLDSMPSQLTPKEPRLCLVDAAYFINTSSPSMFRPGRRLDLILSFDYSLSAPFEALQQT
580 590 600 610 620 630
690 700 710 720 730 740
pF1KE0 ELYCRARGLPFPRVEPSPQDQHQPRECHLFSDPACPEAPILLHFPLVNASFKDHSAPGVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ELYCRARGLPFPRVEPSPQDQHQPRECHLFSDPACPEAPILLHFPLVNASFKDHSAPGVQ
640 650 660 670 680 690
750 760 770 780 790 800
pF1KE0 RSPAELQGGQVDLTGATCPYTLSNMTYKEEDFERLLRLSDYNVQTSQGAILQALRTALKH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RSPAELQGGQVDLTGATCPYTLSNMTYKEEDFERLLRLSDYNVQTSQGAILQALRTALKH
700 710 720 730 740 750
810
pF1KE0 RTLEARPPRAQT
::::::::::::
XP_011 RTLEARPPRAQT
760
>>NP_001108105 (OMIM: 606088) cytosolic phospholipase A2 (781 aa)
initn: 2567 init1: 1272 opt: 2086 Z-score: 2205.5 bits: 419.0 E(85289): 4.1e-116
Smith-Waterman score: 2603; 51.0% identity (75.0% similar) in 800 aa overlap (20-813:9-780)
10 20 30 40 50 60
pF1KE0 MESLSPGGPPGHPYQGEASTCWQLTVRVLEARNLRWADLLSEADPYVILQLSTAPGMKFK
:: ::::::.:. : ::.. .: :: : : :: . ...
NP_001 MAVAEVSRTCL-LTVRVLQAHRLPSKDLVTPSDCYVTLWLPTACSHRLQ
10 20 30 40
70 80 90 100 110 120
pF1KE0 TKTLTDTSHPVWNEAFRFLIQSQVKNVLELSIYDEDSVTEDDICFKVLYDISEVLPGKLL
:.:. ..: ::::..:.: :. :.:::.::...:.: :: :: ..::.: . . :..
NP_001 TRTVKNSSSPVWNQSFHFRIHRQLKNVMELKVFDQDLVTGDDPVLSVLFDAGTLRAGEFR
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE0 RKTFSQSPQGEEELDVEFLMEETSDRPENLITNKVIVARELSCLDVHLDSTGSTAVVADQ
:..:: ::::: .:.::: .. .:: : :..: :.:::::::: :.:. :: ::
NP_001 RESFSLSPQGEGRLEVEFRLQSLADRGEWLVSNGVLVARELSCLHVQLEETG------DQ
110 120 130 140 150 160
190 200 210 220 230
pF1KE0 DKLE--LELVLKGSYEDTQTSFLGTASAFRFHYMAALETELSGRLRSSRSNGWNGDNSAG
. : ..::. :: : : . .::.. :::: : : ::: ::. :
NP_001 KSSEHRVQLVVPGSCEGPQEASVGTGT-FRFHCPACWEQELSIRLQ---------DAPEE
170 180 190 200 210
240 250 260 270 280 290
pF1KE0 YLTVPLRPLTIGKEVTMDVPAPNAPGVRLQLKAEGCPEELAVHLGFNLCAEEQAFLSRRK
: .:: : :. : . :. . : .:..:: :. .::::.:::. ::::::::::::
NP_001 QLKAPLSALPSGQVVRLVFPTSQEPLMRVELKKEAGLRELAVRLGFGPCAEEQAFLSRRK
220 230 240 250 260 270
300 310 320 330 340 350
pF1KE0 QVVAKALKQALQLDRDLQEDEVPVVGIMATGGGARAMTSLYGHLLALQKLGLLDCVTYFS
:::: ::.:::::: ::::::.:::.::::::: ::::::::.: .:..:::::::.:..
NP_001 QVVAAALRQALQLDGDLQEDEIPVVAIMATGGGIRAMTSLYGQLAGLKELGLLDCVSYIT
280 290 300 310 320 330
360 370 380 390 400 410
pF1KE0 GISGSTWTMAHLYGDPEWSQRDLEGPIRYAREHLAKSKLEVFSPERLASYRRELELRAEQ
: :::::..:.:: ::::::.:: :: . . ...:.:: :..: .: ::.:: ::.
NP_001 GASGSTWALANLYEDPEWSQKDLAGPTELLKTQVTKNKLGVLAPSQLQRYRQELAERARL
340 350 360 370 380 390
420 430 440 450 460 470
pF1KE0 GHPTTFVDLWALVLESMLHGQVMDQKLSGQRAALERGQNPLPLYLSLNVKENNLETLDFK
:.:. :..::::. :..:: . :.::: :: :: .::::::.: .::.: ..: :..:
NP_001 GYPSCFTNLWALINEALLHDEPHDHKLSDQREALSHGQNPLPIYCALNTKGQSLTTFEFG
400 410 420 430 440 450
480 490 500 510 520 530
pF1KE0 EWVEFSPYEVGFLKYGAFVPPELFGSEFFMGRLMRRIPEPRICFLEAIWSNIFSLNLLDA
:: ::::::::: :::::.: ::::::::::.::.:.:: ::::::.::::... :: :.
NP_001 EWCEFSPYEVGFPKYGAFIPSELFGSEFFMGQLMKRLPESRICFLEGIWSNLYAANLQDS
460 470 480 490 500 510
540 550 560 570 580 590
pF1KE0 WYDLTSSGESWKQHIKDKTRSLEKE--PLTTSGTSSRLEASWLQPGTA--LAQAFKGFLT
: . .. : . ..... .:.:: :: ..: :.:: .:. : .::
NP_001 LYWASEPSQFWDRWVRNQA-NLDKEQVPLL------KIEE---PPSTAGRIAEFFTDLLT
520 530 540 550 560
600 610 620 630 640 650
pF1KE0 GRPLHQRSPNFLQGLQLHQDYCSHKDFSTWADYQLDSMPSQLTPKEPRLCLVDAAYFINT
::: : . :::.::..:.:: .: :::: ::..:.::::.::.:::.:..:.:::
NP_001 WRPLAQATHNFLRGLHFHKDYFQHPHFSTWKATTLDGLPNQLTPSEPHLCLLDVGYLINT
570 580 590 600 610 620
660 670 680 690 700 710
pF1KE0 SSPSMFRPGRRLDLILSFDYSLSAPFEALQQTELYCRARGLPFPRVEPSPQDQHQPRECH
: ...: : .:::::.::.: . :. :: .:. .:.::: . :::..: ::::::
NP_001 SCLPLLQPTRDVDLILSLDYNLHGAFQQLQLLGRFCQEQGIPFPPISPSPEEQLQPRECH
630 640 650 660 670 680
720 730 740 750 760 770
pF1KE0 LFSDPACPEAPILLHFPLVNASFKDHSAPGVQRSPAELQGGQVDLTGATCPYTLSNMTYK
::::.:: :: .::::::. ::...:::::.:.: : .:.:.:... :: ...::.
NP_001 TFSDPTCPGAPAVLHFPLVSDSFREYSAPGVRRTPEEAAAGEVNLSSSDSPYHYTKVTYS
690 700 710 720 730 740
780 790 800 810
pF1KE0 EEDFERLLRLSDYNVQTSQGAILQALRTALKHRTLEARPPRAQT
.:: ..::.:. ::: ..: .:.::: :...: . ::
NP_001 QEDVDKLLHLTHYNVCNNQEQLLEALRQAVQRRR-QRRPH
750 760 770 780
>>XP_011507944 (OMIM: 600522) PREDICTED: cytosolic phosp (749 aa)
initn: 933 init1: 342 opt: 643 Z-score: 679.8 bits: 136.6 E(85289): 4e-31
Smith-Waterman score: 923; 30.4% identity (61.5% similar) in 621 aa overlap (234-800:99-712)
210 220 230 240 250 260
pF1KE0 ASAFRFHYMAALETELSGRLRSSRSNGWNGDNSAGYLTVPLRPLTIG--KEVTMDVPAPN
:.. : : . . .: ::: . .
XP_011 PVWNETFEFILDPNQENVLEITLMDANYVMDETLGTATFTVSSMKVGEKKEVPFIFNQVT
70 80 90 100 110 120
270 280 290 300 310
pF1KE0 APGVRLQLKAEGCPEELAVHLGFNLCAEEQAFLSRRKQVVAKALKQAL--QLDRDLQED-
....:.. .::. ..... :: .:..: ..::. . ...:. : . .. :.
XP_011 EMVLEMSLEVCSCPD---LRFSMALCDQEKTFRQQRKEHIRESMKKLLGPKNSEGLHSAR
130 140 150 160 170 180
320 330 340 350 360 370
pF1KE0 EVPVVGIMATGGGARAMTSLYGHLLALQKLGLLDCVTYFSGISGSTWTMAHLYGDPEWSQ
.::::.:...::: :::... : . :: . :.:::.:: .:.::::: :. ::. :.. .
XP_011 DVPVVAILGSGGGFRAMVGFSGVMKALYESGILDCATYVAGLSGSTWYMSTLYSHPDFPE
190 200 210 220 230 240
380 390 400 410 420 430
pF1KE0 RDLEGPIRYAREHLAKSKLEVFSPERLASYRRELELRAEQGHPTTFVDLWALVL-ESMLH
. : . ...... : ...:... : . : . .:.:.::.:...... :...:
XP_011 KGPEEINEELMKNVSHNPLLLLTPQKVKRYVESLWKKKSSGQPVTFTDIFGMLIGETLIH
250 260 270 280 290 300
440 450 460 470 480 490
pF1KE0 GQVMDQKLSGQRAALERGQNPLPLYLSLNVKENNLETLDFKEWVEFSPYEVGFLKYGAFV
.. :. ::. . .. .: ::::. :.:: . : . : .::::::::.:. :::.:.
XP_011 NR-MNTTLSSLKEKVNTAQCPLPLFTCLHVKPDVSELM-FADWVEFSPYEIGMAKYGTFM
310 320 330 340 350 360
500 510 520 530 540 550
pF1KE0 PPELFGSEFFMGRLMRRIPEPRICFLEAIWSNIFSLNLLDAWYDLTSS---GESWKQ---
:.::::.:::: .... : . :: ..:.. ::. :.. ...: : . ..
XP_011 APDLFGSKFFMGTVVKKYEENPLHFLMGVWGSAFSI-LFNRVLGVSGSQSRGSTMEEELE
370 380 390 400 410 420
560 570 580 590
pF1KE0 -----HI--KDKTRSLEK--EPLTT------SGTSSRLEASWLQPGT-ALAQAFKGFLTG
:: .:.. : .. :: : : .: .:::.. ::.. : :
XP_011 NITTKHIVSNDSSDSDDESHEPKGTENEDAGSDYQSDNQASWIHRMIMALVSDSALFNTR
430 440 450 460 470 480
600 610 620 630 640
pF1KE0 RPLHQRSPNFLQGLQLHQDY--CSHKDFST---WADYQLDSM---PSQ-------LTPKE
. . ::. ::.:. .: .::.: . : .::. :.. : :
XP_011 EGRAGKVHNFMLGLNLNTSYPLSPLSDFATQDSFDDDELDAAVADPDEFERIYEPLDVKS
490 500 510 520 530 540
650 660 670 680 690
pF1KE0 PRLCLVDAAYFINTSSPSMFRPGRRLDLILSFDYSL-----SAPFEALQQTELYCRARGL
.. .::.. .: : ..:: : .:::.:::.: : ::. : .: . . :
XP_011 KKIHVVDSGLTFNLPYPLILRPQRGVDLIISFDFSARPSDSSPPFKELLLAEKWAKMNKL
550 560 570 580 590 600
700 710 720 730 740 750
pF1KE0 PFPRVEPSPQDQHQPRECHLFSDPACPEA----PILLHFPLVNASFKDHSAPGVQR-SPA
:::...: :.. .::..:. : :. : ..:: :.: .:. . :::: : .
XP_011 PFPKIDPYVFDREGLKECYVFK-PKNPDMEKDCPTIIHFVLANINFRKYRAPGVPRETEE
610 620 630 640 650 660
760 770 780 790 800
pF1KE0 ELQGGQVDL-TGATCPYTLSNMTYKEEDFERLLRLSDYNVQTSQGAILQALRTALKHRTL
: . .. :. :.. :. : .. :.:: : .:. .. .: .:.
XP_011 EKEIADFDIFDDPESPFSTFNFQYPNQAFKRLHDLMHFNTLNNIDVIKEAMVESIEYRRQ
670 680 690 700 710 720
810
pF1KE0 EARPPRAQT
XP_011 NPSRCSVSLSNVEARRFFNKEFLSKPKA
730 740
>>NP_077734 (OMIM: 600522) cytosolic phospholipase A2 is (749 aa)
initn: 934 init1: 342 opt: 643 Z-score: 679.8 bits: 136.6 E(85289): 4e-31
Smith-Waterman score: 924; 30.4% identity (61.7% similar) in 621 aa overlap (234-800:99-712)
210 220 230 240 250 260
pF1KE0 ASAFRFHYMAALETELSGRLRSSRSNGWNGDNSAGYLTVPLRPLTIG--KEVTMDVPAPN
:.. : : . . .: ::: . .
NP_077 PVWNETFEFILDPNQENVLEITLMDANYVMDETLGTATFTVSSMKVGEKKEVPFIFNQVT
70 80 90 100 110 120
270 280 290 300 310
pF1KE0 APGVRLQLKAEGCPEELAVHLGFNLCAEEQAFLSRRKQVVAKALKQAL--QLDRDLQED-
....:.. .::. ..... :: .:..: ..::. . ...:. : . .. :.
NP_077 EMVLEMSLEVCSCPD---LRFSMALCDQEKTFRQQRKEHIRESMKKLLGPKNSEGLHSAR
130 140 150 160 170 180
320 330 340 350 360 370
pF1KE0 EVPVVGIMATGGGARAMTSLYGHLLALQKLGLLDCVTYFSGISGSTWTMAHLYGDPEWSQ
.::::.:...::: :::... : . :: . :.:::.:: .:.::::: :. ::. :.. .
NP_077 DVPVVAILGSGGGFRAMVGFSGVMKALYESGILDCATYVAGLSGSTWYMSTLYSHPDFPE
190 200 210 220 230 240
380 390 400 410 420 430
pF1KE0 RDLEGPIRYAREHLAKSKLEVFSPERLASYRRELELRAEQGHPTTFVDLWALVL-ESMLH
. : . ...... : ...:... : . : . .:.:.::.:...... :...:
NP_077 KGPEEINEELMKNVSHNPLLLLTPQKVKRYVESLWKKKSSGQPVTFTDIFGMLIGETLIH
250 260 270 280 290 300
440 450 460 470 480 490
pF1KE0 GQVMDQKLSGQRAALERGQNPLPLYLSLNVKENNLETLDFKEWVEFSPYEVGFLKYGAFV
.. :. ::. . .. .: ::::. :.:: . : . : .::::::::.:. :::.:.
NP_077 NR-MNTTLSSLKEKVNTAQCPLPLFTCLHVKPDVSELM-FADWVEFSPYEIGMAKYGTFM
310 320 330 340 350 360
500 510 520 530 540 550
pF1KE0 PPELFGSEFFMGRLMRRIPEPRICFLEAIWSNIFSLNLLDAWYDLTSS---GESWKQ---
:.::::.:::: .... : . :: ..:.. ::. :.. ...: : . ..
NP_077 APDLFGSKFFMGTVVKKYEENPLHFLMGVWGSAFSI-LFNRVLGVSGSQSRGSTMEEELE
370 380 390 400 410 420
560 570 580 590
pF1KE0 -----HI--KDKTRSLEK--EPLTT------SGTSSRLEASWLQPGT-ALAQAFKGFLTG
:: .:.. : .. :: : : .: .:::.. ::.. : :
NP_077 NITTKHIVSNDSSDSDDESHEPKGTENEDAGSDYQSDNQASWIHRMIMALVSDSALFNTR
430 440 450 460 470 480
600 610 620 630 640
pF1KE0 RPLHQRSPNFLQGLQLHQDY--CSHKDFST---WADYQLDSM---PSQ-------LTPKE
. . ::. ::.:. .: .::.: . : .::. :.. : :
NP_077 EGRAGKVHNFMLGLNLNTSYPLSPLSDFATQDSFDDDELDAAVADPDEFERIYEPLDVKS
490 500 510 520 530 540
650 660 670 680 690
pF1KE0 PRLCLVDAAYFINTSSPSMFRPGRRLDLILSFDYSL-----SAPFEALQQTELYCRARGL
.. .::.. .: : ..:: : .:::.:::.: : ::. : .: . . :
NP_077 KKIHVVDSGLTFNLPYPLILRPQRGVDLIISFDFSARPSDSSPPFKELLLAEKWAKMNKL
550 560 570 580 590 600
700 710 720 730 740 750
pF1KE0 PFPRVEPSPQDQHQPRECHLFSDPACPEA----PILLHFPLVNASFKDHSAPGVQR-SPA
:::...: :.. .::..:. : :. : ..:: :.: .:. ..:::: : .
NP_077 PFPKIDPYVFDREGLKECYVFK-PKNPDMEKDCPTIIHFVLANINFRKYKAPGVPRETEE
610 620 630 640 650 660
760 770 780 790 800
pF1KE0 ELQGGQVDL-TGATCPYTLSNMTYKEEDFERLLRLSDYNVQTSQGAILQALRTALKHRTL
: . .. :. :.. :. : .. :.:: : .:. .. .: .:.
NP_077 EKEIADFDIFDDPESPFSTFNFQYPNQAFKRLHDLMHFNTLNNIDVIKEAMVESIEYRRQ
670 680 690 700 710 720
810
pF1KE0 EARPPRAQT
NP_077 NPSRCSVSLSNVEARRFFNKEFLSKPKA
730 740
>>XP_005245324 (OMIM: 600522) PREDICTED: cytosolic phosp (754 aa)
initn: 933 init1: 342 opt: 643 Z-score: 679.7 bits: 136.6 E(85289): 4e-31
Smith-Waterman score: 923; 30.4% identity (61.5% similar) in 621 aa overlap (234-800:104-717)
210 220 230 240 250 260
pF1KE0 ASAFRFHYMAALETELSGRLRSSRSNGWNGDNSAGYLTVPLRPLTIG--KEVTMDVPAPN
:.. : : . . .: ::: . .
XP_005 PVWNETFEFILDPNQENVLEITLMDANYVMDETLGTATFTVSSMKVGEKKEVPFIFNQVT
80 90 100 110 120 130
270 280 290 300 310
pF1KE0 APGVRLQLKAEGCPEELAVHLGFNLCAEEQAFLSRRKQVVAKALKQAL--QLDRDLQED-
....:.. .::. ..... :: .:..: ..::. . ...:. : . .. :.
XP_005 EMVLEMSLEVCSCPD---LRFSMALCDQEKTFRQQRKEHIRESMKKLLGPKNSEGLHSAR
140 150 160 170 180 190
320 330 340 350 360 370
pF1KE0 EVPVVGIMATGGGARAMTSLYGHLLALQKLGLLDCVTYFSGISGSTWTMAHLYGDPEWSQ
.::::.:...::: :::... : . :: . :.:::.:: .:.::::: :. ::. :.. .
XP_005 DVPVVAILGSGGGFRAMVGFSGVMKALYESGILDCATYVAGLSGSTWYMSTLYSHPDFPE
200 210 220 230 240 250
380 390 400 410 420 430
pF1KE0 RDLEGPIRYAREHLAKSKLEVFSPERLASYRRELELRAEQGHPTTFVDLWALVL-ESMLH
. : . ...... : ...:... : . : . .:.:.::.:...... :...:
XP_005 KGPEEINEELMKNVSHNPLLLLTPQKVKRYVESLWKKKSSGQPVTFTDIFGMLIGETLIH
260 270 280 290 300 310
440 450 460 470 480 490
pF1KE0 GQVMDQKLSGQRAALERGQNPLPLYLSLNVKENNLETLDFKEWVEFSPYEVGFLKYGAFV
.. :. ::. . .. .: ::::. :.:: . : . : .::::::::.:. :::.:.
XP_005 NR-MNTTLSSLKEKVNTAQCPLPLFTCLHVKPDVSELM-FADWVEFSPYEIGMAKYGTFM
320 330 340 350 360
500 510 520 530 540 550
pF1KE0 PPELFGSEFFMGRLMRRIPEPRICFLEAIWSNIFSLNLLDAWYDLTSS---GESWKQ---
:.::::.:::: .... : . :: ..:.. ::. :.. ...: : . ..
XP_005 APDLFGSKFFMGTVVKKYEENPLHFLMGVWGSAFSI-LFNRVLGVSGSQSRGSTMEEELE
370 380 390 400 410 420
560 570 580 590
pF1KE0 -----HI--KDKTRSLEK--EPLTT------SGTSSRLEASWLQPGT-ALAQAFKGFLTG
:: .:.. : .. :: : : .: .:::.. ::.. : :
XP_005 NITTKHIVSNDSSDSDDESHEPKGTENEDAGSDYQSDNQASWIHRMIMALVSDSALFNTR
430 440 450 460 470 480
600 610 620 630 640
pF1KE0 RPLHQRSPNFLQGLQLHQDY--CSHKDFST---WADYQLDSM---PSQ-------LTPKE
. . ::. ::.:. .: .::.: . : .::. :.. : :
XP_005 EGRAGKVHNFMLGLNLNTSYPLSPLSDFATQDSFDDDELDAAVADPDEFERIYEPLDVKS
490 500 510 520 530 540
650 660 670 680 690
pF1KE0 PRLCLVDAAYFINTSSPSMFRPGRRLDLILSFDYSL-----SAPFEALQQTELYCRARGL
.. .::.. .: : ..:: : .:::.:::.: : ::. : .: . . :
XP_005 KKIHVVDSGLTFNLPYPLILRPQRGVDLIISFDFSARPSDSSPPFKELLLAEKWAKMNKL
550 560 570 580 590 600
700 710 720 730 740 750
pF1KE0 PFPRVEPSPQDQHQPRECHLFSDPACPEA----PILLHFPLVNASFKDHSAPGVQR-SPA
:::...: :.. .::..:. : :. : ..:: :.: .:. . :::: : .
XP_005 PFPKIDPYVFDREGLKECYVFK-PKNPDMEKDCPTIIHFVLANINFRKYRAPGVPRETEE
610 620 630 640 650 660
760 770 780 790 800
pF1KE0 ELQGGQVDL-TGATCPYTLSNMTYKEEDFERLLRLSDYNVQTSQGAILQALRTALKHRTL
: . .. :. :.. :. : .. :.:: : .:. .. .: .:.
XP_005 EKEIADFDIFDDPESPFSTFNFQYPNQAFKRLHDLMHFNTLNNIDVIKEAMVESIEYRRQ
670 680 690 700 710 720
810
pF1KE0 EARPPRAQT
XP_005 NPSRCSVSLSNVEARRFFNKEFLSKPKA
730 740 750
>>NP_001298122 (OMIM: 600522) cytosolic phospholipase A2 (689 aa)
initn: 947 init1: 340 opt: 582 Z-score: 615.8 bits: 124.6 E(85289): 1.5e-27
Smith-Waterman score: 863; 32.0% identity (62.0% similar) in 532 aa overlap (318-800:125-652)
290 300 310 320 330 340
pF1KE0 AEEQAFLSRRKQVVAKALKQALQLDRDLQEDEVPVVGIMATGGGARAMTSLYGHLLALQK
..::::.:...::: :::... : . :: .
NP_001 NYVMDETLGTATFTVSSMKVGEKKEVPFIFNQVPVVAILGSGGGFRAMVGFSGVMKALYE
100 110 120 130 140 150
350 360 370 380 390 400
pF1KE0 LGLLDCVTYFSGISGSTWTMAHLYGDPEWSQRDLEGPIRYAREHLAKSKLEVFSPERLAS
:.:::.:: .:.::::: :. ::. :.. .. : . ...... : ...:...
NP_001 SGILDCATYVAGLSGSTWYMSTLYSHPDFPEKGPEEINEELMKNVSHNPLLLLTPQKVKR
160 170 180 190 200 210
410 420 430 440 450 460
pF1KE0 YRRELELRAEQGHPTTFVDLWALVL-ESMLHGQVMDQKLSGQRAALERGQNPLPLYLSLN
: . : . .:.:.::.:...... :...:.. :. ::. . .. .: ::::. :.
NP_001 YVESLWKKKSSGQPVTFTDIFGMLIGETLIHNR-MNTTLSSLKEKVNTAQCPLPLFTCLH
220 230 240 250 260 270
470 480 490 500 510 520
pF1KE0 VKENNLETLDFKEWVEFSPYEVGFLKYGAFVPPELFGSEFFMGRLMRRIPEPRICFLEAI
:: . : . : .::::::::.:. :::.:. :.::::.:::: .... : . :: ..
NP_001 VKPDVSELM-FADWVEFSPYEIGMAKYGTFMAPDLFGSKFFMGTVVKKYEENPLHFLMGV
280 290 300 310 320 330
530 540 550 560
pF1KE0 WSNIFSLNLLDAWYDLTSS---GESWKQ--------HI--KDKTRSLEK--EPLTT----
:.. ::. :.. ...: : . .. :: .:.. : .. :: :
NP_001 WGSAFSI-LFNRVLGVSGSQSRGSTMEEELENITTKHIVSNDSSDSDDESHEPKGTENED
340 350 360 370 380 390
570 580 590 600 610 620
pF1KE0 --SGTSSRLEASWLQPGT-ALAQAFKGFLTGRPLHQRSPNFLQGLQLHQDY--CSHKDFS
: .: .:::.. ::.. : : . . ::. ::.:. .: .::.
NP_001 AGSDYQSDNQASWIHRMIMALVSDSALFNTREGRAGKVHNFMLGLNLNTSYPLSPLSDFA
400 410 420 430 440 450
630 640 650 660
pF1KE0 T---WADYQLDSM---PSQ-------LTPKEPRLCLVDAAYFINTSSPSMFRPGRRLDLI
: . : .::. :.. : : .. .::.. .: : ..:: : .:::
NP_001 TQDSFDDDELDAAVADPDEFERIYEPLDVKSKKIHVVDSGLTFNLPYPLILRPQRGVDLI
460 470 480 490 500 510
670 680 690 700 710 720
pF1KE0 LSFDYSL-----SAPFEALQQTELYCRARGLPFPRVEPSPQDQHQPRECHLFSDPACPEA
.:::.: : ::. : .: . . ::::...: :.. .::..:. : :.
NP_001 ISFDFSARPSDSSPPFKELLLAEKWAKMNKLPFPKIDPYVFDREGLKECYVFK-PKNPDM
520 530 540 550 560 570
730 740 750 760 770
pF1KE0 ----PILLHFPLVNASFKDHSAPGVQR-SPAELQGGQVDL-TGATCPYTLSNMTYKEEDF
: ..:: :.: .:. ..:::: : . : . .. :. :.. :. : .. :
NP_001 EKDCPTIIHFVLANINFRKYKAPGVPRETEEEKEIADFDIFDDPESPFSTFNFQYPNQAF
580 590 600 610 620 630
780 790 800 810
pF1KE0 ERLLRLSDYNVQTSQGAILQALRTALKHRTLEARPPRAQT
.:: : .:. .. .: .:.
NP_001 KRLHDLMHFNTLNNIDVIKEAMVESIEYRRQNPSRCSVSLSNVEARRFFNKEFLSKPKA
640 650 660 670 680
>--
initn: 190 init1: 160 opt: 188 Z-score: 199.2 bits: 47.5 E(85289): 0.00023
Smith-Waterman score: 188; 34.0% identity (69.1% similar) in 97 aa overlap (13-103:6-102)
10 20 30 40 50
pF1KE0 MESLSPGGPPGHPYQG---EASTCWQLTVRVLEARNLR---WADLLSEADPYVILQLSTA
::: : . ..:: ::.: .. ..:.:. :::: : .::.
NP_001 MSFIDPYQHIIVEHQYSHKFTVVVLRATKVTKGAFGDMLDTPDPYVELFISTT
10 20 30 40 50
60 70 80 90 100 110
pF1KE0 PGMKFKTKTLTDTSHPVWNEAFRFLIQSQVKNVLELSIYDEDSVTEDDICFKVLYDISEV
: . .:. ... .:::::.:.:... . .::::....: . : .. .
NP_001 PDSRKRTRHFNNDINPVWNETFEFILDPNQENVLEITLMDANYVMDETLGTATFTVSSMK
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE0 LPGKLLRKTFSQSPQGEEELDVEFLMEETSDRPENLITNKVIVARELSCLDVHLDSTGST
NP_001 VGEKKEVPFIFNQVPVVAILGSGGGFRAMVGFSGVMKALYESGILDCATYVAGLSGSTWY
120 130 140 150 160 170
>>XP_016882900 (OMIM: 603602) PREDICTED: cytosolic phosp (509 aa)
initn: 545 init1: 195 opt: 417 Z-score: 443.4 bits: 92.3 E(85289): 5.9e-18
Smith-Waterman score: 660; 30.2% identity (59.4% similar) in 473 aa overlap (286-734:12-453)
260 270 280 290 300 310
pF1KE0 DVPAPNAPGVRLQLKAEGCPEELAVHLGFNLCAEEQAFLSRRKQVVAKALKQALQLDRDL
: ::.: . ::. : ::::. .
XP_016 MGSSEVSIIPGLQKEEKAAVERRRLHVLKALKKL-----RI
10 20 30
320 330 340 350 360 370
pF1KE0 QEDEVPVVGIMATGGGARAMTSLYGHLLALQKLGLLDCVTYFSGISGSTWTMAHLY---G
. ::.:::.....::: :: . : : ... :::: :::..:.:::::... :: :
XP_016 EADEAPVVAVLGSGGGLRAHIACLGVLSEMKEQGLLDAVTYLAGVSGSTWAISSLYTNDG
40 50 60 70 80 90
380 390 400 410 420 430
pF1KE0 DPEWSQRDLEGPIRYAREH--LAKSKLEVFSPERLASYRRELELRAEQGHPTTFVDLWAL
: : . ::. :..:.. :::: .... : .: ...:.::
XP_016 DMEALEADLKH--RFTRQEWDLAKSLQKTIQAARSENY--------------SLTDFWAY
100 110 120 130 140
440 450 460 470 480
pF1KE0 VLESMLHGQVMDQKLSGQRAALERGQNPLPLYLSLN--VKENNLETLDFKEWVEFSPYEV
.. : .. ...::... .:.: : :.. ... .. . :. . : ::.:...
XP_016 MVISKQTRELPESHLSNMKKPVEEGTLPYPIFAAIDNDLQPSWQEARAPETWFEFTPHHA
150 160 170 180 190 200
490 500 510 520 530 540
pF1KE0 GFLKYGAFVPPELFGSEFFMGRLMRRIPEPRICFLEAIW------SNIFSLNLLDAWYDL
:: :::: :::.: :::.: :: . ::...: .... ..: .:
XP_016 GFSALGAFVSITHFGSKFKKGRLVRTHPERDLTFLRGLWGSALGNTEVIREYIFDQLRNL
210 220 230 240 250 260
550 560 570 580 590 600
pF1KE0 TSSGESWKQHIKDKTRSLEKEPLTTSGTSSRLEASWLQPGTALAQAFKGFLTGRPLHQRS
: .: :.. . . ..:. . . .: : .:: : . . : . ...
XP_016 TLKGL-WRRAVAN-AKSIGHLIFDEGGEP---EHTWLT--EMLENWTRTSLEKQEQPHED
270 280 290 300 310
610 620 630 640 650
pF1KE0 PNFLQGLQLHQDY------CSHK-DFSTWAD--YQLDSMPSQLTPKEPRLCLVDAAYFIN
:. .:. .:. :. : ...: . :. .. ... .. .: ::::. ::
XP_016 PERKGSLSNLMDFVKKTGICASKWEWGTTHNFLYKHGGIRDKIMSSRKHLHLVDAGLAIN
320 330 340 350 360 370
660 670 680 690 700 710
pF1KE0 TSSPSMFRPGRRLDLILSFDYSLSAPFEALQQTELYCRARGLPFPRVEPSPQD--QHQPR
: : .. : :.. ::::::.: . :::... : ::: . .:::.:: . : .. :
XP_016 TPFPLVLPPTREVHLILSFDFSAGDPFETIRATTDYCRRHKIPFPQVEEAELDLWSKAPA
380 390 400 410 420 430
720 730 740 750 760 770
pF1KE0 ECHLFSDPACPEAPILLHFPLVNASFKDHSAPGVQRSPAELQGGQVDLTGATCPYTLSNM
:.... . .:...:::: :
XP_016 SCYILKGET---GPVVMHFPLFNIDACGGDIEAWSDTYDTFKLADTYTLDVVVLLLALAK
440 450 460 470 480 490
>>XP_011525733 (OMIM: 603602) PREDICTED: cytosolic phosp (523 aa)
initn: 545 init1: 195 opt: 417 Z-score: 443.2 bits: 92.3 E(85289): 6e-18
Smith-Waterman score: 660; 30.2% identity (59.4% similar) in 473 aa overlap (286-734:12-453)
260 270 280 290 300 310
pF1KE0 DVPAPNAPGVRLQLKAEGCPEELAVHLGFNLCAEEQAFLSRRKQVVAKALKQALQLDRDL
: ::.: . ::. : ::::. .
XP_011 MGSSEVSIIPGLQKEEKAAVERRRLHVLKALKKL-----RI
10 20 30
320 330 340 350 360 370
pF1KE0 QEDEVPVVGIMATGGGARAMTSLYGHLLALQKLGLLDCVTYFSGISGSTWTMAHLY---G
. ::.:::.....::: :: . : : ... :::: :::..:.:::::... :: :
XP_011 EADEAPVVAVLGSGGGLRAHIACLGVLSEMKEQGLLDAVTYLAGVSGSTWAISSLYTNDG
40 50 60 70 80 90
380 390 400 410 420 430
pF1KE0 DPEWSQRDLEGPIRYAREH--LAKSKLEVFSPERLASYRRELELRAEQGHPTTFVDLWAL
: : . ::. :..:.. :::: .... : .: ...:.::
XP_011 DMEALEADLKH--RFTRQEWDLAKSLQKTIQAARSENY--------------SLTDFWAY
100 110 120 130 140
440 450 460 470 480
pF1KE0 VLESMLHGQVMDQKLSGQRAALERGQNPLPLYLSLN--VKENNLETLDFKEWVEFSPYEV
.. : .. ...::... .:.: : :.. ... .. . :. . : ::.:...
XP_011 MVISKQTRELPESHLSNMKKPVEEGTLPYPIFAAIDNDLQPSWQEARAPETWFEFTPHHA
150 160 170 180 190 200
490 500 510 520 530 540
pF1KE0 GFLKYGAFVPPELFGSEFFMGRLMRRIPEPRICFLEAIW------SNIFSLNLLDAWYDL
:: :::: :::.: :::.: :: . ::...: .... ..: .:
XP_011 GFSALGAFVSITHFGSKFKKGRLVRTHPERDLTFLRGLWGSALGNTEVIREYIFDQLRNL
210 220 230 240 250 260
550 560 570 580 590 600
pF1KE0 TSSGESWKQHIKDKTRSLEKEPLTTSGTSSRLEASWLQPGTALAQAFKGFLTGRPLHQRS
: .: :.. . . ..:. . . .: : .:: : . . : . ...
XP_011 TLKGL-WRRAVAN-AKSIGHLIFDEGGEP---EHTWLT--EMLENWTRTSLEKQEQPHED
270 280 290 300 310
610 620 630 640 650
pF1KE0 PNFLQGLQLHQDY------CSHK-DFSTWAD--YQLDSMPSQLTPKEPRLCLVDAAYFIN
:. .:. .:. :. : ...: . :. .. ... .. .: ::::. ::
XP_011 PERKGSLSNLMDFVKKTGICASKWEWGTTHNFLYKHGGIRDKIMSSRKHLHLVDAGLAIN
320 330 340 350 360 370
660 670 680 690 700 710
pF1KE0 TSSPSMFRPGRRLDLILSFDYSLSAPFEALQQTELYCRARGLPFPRVEPSPQD--QHQPR
: : .. : :.. ::::::.: . :::... : ::: . .:::.:: . : .. :
XP_011 TPFPLVLPPTREVHLILSFDFSAGDPFETIRATTDYCRRHKIPFPQVEEAELDLWSKAPA
380 390 400 410 420 430
720 730 740 750 760 770
pF1KE0 ECHLFSDPACPEAPILLHFPLVNASFKDHSAPGVQRSPAELQGGQVDLTGATCPYTLSNM
:.... . .:...:::: :
XP_011 SCYILKGET---GPVVMHFPLFNIDACGGDIEAWSDTYDTFKLADTYTLDVVVLLLALAK
440 450 460 470 480 490
>>XP_016882903 (OMIM: 603602) PREDICTED: cytosolic phosp (282 aa)
initn: 368 init1: 195 opt: 254 Z-score: 275.0 bits: 60.3 E(85289): 1.4e-08
Smith-Waterman score: 441; 32.2% identity (61.1% similar) in 283 aa overlap (286-555:12-272)
260 270 280 290 300 310
pF1KE0 DVPAPNAPGVRLQLKAEGCPEELAVHLGFNLCAEEQAFLSRRKQVVAKALKQALQLDRDL
: ::.: . ::. : ::::. :...
XP_016 MGSSEVSIIPGLQKEEKAAVERRRLHVLKALKK-LRIE---
10 20 30
320 330 340 350 360 370
pF1KE0 QEDEVPVVGIMATGGGARAMTSLYGHLLALQKLGLLDCVTYFSGISGSTWTMAHLY---G
::.:::.....::: :: . : : ... :::: :::..:.:::::... :: :
XP_016 -ADEAPVVAVLGSGGGLRAHIACLGVLSEMKEQGLLDAVTYLAGVSGSTWAISSLYTNDG
40 50 60 70 80 90
380 390 400 410 420 430
pF1KE0 DPEWSQRDLEGPIRYAREH--LAKSKLEVFSPERLASYRRELELRAEQGHPTTFVDLWAL
: : . ::. :..:.. :::: .... : .: ...:.::
XP_016 DMEALEADLKH--RFTRQEWDLAKSLQKTIQAARSENY--------------SLTDFWAY
100 110 120 130 140
440 450 460 470 480
pF1KE0 VLESMLHGQVMDQKLSGQRAALERGQNPLPLYLSLN--VKENNLETLDFKEWVEFSPYEV
.. : .. ...::... .:.: : :.. ... .. . :. . : ::.:...
XP_016 MVISKQTRELPESHLSNMKKPVEEGTLPYPIFAAIDNDLQPSWQEARAPETWFEFTPHHA
150 160 170 180 190 200
490 500 510 520 530 540
pF1KE0 GFLKYGAFVPPELFGSEFFMGRLMRRIPEPRICFLEAIW------SNIFSLNLLDAWYDL
:: :::: :::.: :::.: :: . ::...: .... ..: .:
XP_016 GFSALGAFVSITHFGSKFKKGRLVRTHPERDLTFLRGLWGSALGNTEVIREYIFDQLRNL
210 220 230 240 250 260
550 560 570 580 590 600
pF1KE0 TSSGESWKQHIKDKTRSLEKEPLTTSGTSSRLEASWLQPGTALAQAFKGFLTGRPLHQRS
: .: :.. . .
XP_016 TLKGL-WRRAVANAKSIGHLIFV
270 280
818 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 14:45:29 2016 done: Thu Nov 3 14:45:31 2016
Total Scan time: 12.910 Total Display time: 0.170
Function used was FASTA [36.3.4 Apr, 2011]