FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0362, 530 aa 1>>>pF1KE0362 530 - 530 aa - 530 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.0354+/-0.000463; mu= 19.5446+/- 0.028 mean_var=65.8615+/-12.948, 0's: 0 Z-trim(109.0): 77 B-trim: 0 in 0/49 Lambda= 0.158037 statistics sampled from 17017 (17094) to 17017 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.547), E-opt: 0.2 (0.2), width: 16 Scan time: 8.410 The best scores are: opt bits E(85289) NP_061950 (OMIM: 606432) UDP-glucuronosyltransfera ( 530) 3606 831.8 0 NP_061949 (OMIM: 606433) UDP-glucuronosyltransfera ( 530) 3387 781.8 0 NP_061948 (OMIM: 606435) UDP-glucuronosyltransfera ( 530) 3380 780.2 0 NP_066307 (OMIM: 606434) UDP-glucuronosyltransfera ( 530) 3349 773.2 0 NP_001063 (OMIM: 606431) UDP-glucuronosyltransfera ( 532) 2384 553.1 7.4e-157 NP_061966 (OMIM: 606428) UDP-glucuronosyltransfera ( 534) 2368 549.5 9.3e-156 NP_061951 (OMIM: 606430) UDP-glucuronosyltransfera ( 534) 2363 548.4 2e-155 NP_000454 (OMIM: 143500,191740,218800,237900,60181 ( 533) 2357 547.0 5.3e-155 NP_009051 (OMIM: 606429) UDP-glucuronosyltransfera ( 534) 2343 543.8 4.8e-154 NP_995584 (OMIM: 606431) UDP-glucuronosyltransfera ( 265) 1736 405.2 1.3e-112 NP_001068 (OMIM: 601903,612560) UDP-glucuronosyltr ( 530) 1524 357.1 7.8e-98 NP_001067 (OMIM: 600069) UDP-glucuronosyltransfera ( 530) 1511 354.1 6.1e-97 NP_001066 (OMIM: 600070) UDP-glucuronosyltransfera ( 528) 1472 345.2 2.9e-94 NP_001065 (OMIM: 600068) UDP-glucuronosyltransfera ( 529) 1465 343.6 8.7e-94 XP_016864074 (OMIM: 600070) PREDICTED: UDP-glucuro ( 525) 1455 341.3 4.2e-93 NP_066962 (OMIM: 600067) UDP-glucuronosyltransfera ( 528) 1448 339.7 1.3e-92 NP_079019 (OMIM: 616382) UDP-glucuronosyltransfera ( 527) 1446 339.3 1.8e-92 NP_001064 (OMIM: 603064) UDP-glucuronosyltransfera ( 529) 1440 337.9 4.5e-92 NP_444267 (OMIM: 606497) UDP-glucuronosyltransfera ( 529) 1435 336.8 1e-91 NP_006789 (OMIM: 604716) UDP-glucuronosyltransfera ( 527) 1421 333.6 9.1e-91 XP_011530549 (OMIM: 616382) PREDICTED: UDP-glucuro ( 533) 1308 307.8 5.2e-83 NP_001284545 (OMIM: 600067) UDP-glucuronosyltransf ( 392) 1276 300.4 6.5e-81 NP_001138239 (OMIM: 600070) UDP-glucuronosyltransf ( 444) 1175 277.4 6.1e-74 NP_001277020 (OMIM: 600070) UDP-glucuronosyltransf ( 280) 1159 273.7 5.3e-73 XP_005265759 (OMIM: 600068) PREDICTED: UDP-glucuro ( 280) 1150 271.6 2.2e-72 XP_011529852 (OMIM: 603064) PREDICTED: UDP-glucuro ( 445) 1141 269.7 1.3e-71 NP_001309042 (OMIM: 601291) 2-hydroxyacylsphingosi ( 541) 1128 266.8 1.2e-70 NP_001309041 (OMIM: 601291) 2-hydroxyacylsphingosi ( 541) 1128 266.8 1.2e-70 NP_001309043 (OMIM: 601291) 2-hydroxyacylsphingosi ( 541) 1128 266.8 1.2e-70 NP_001121646 (OMIM: 601291) 2-hydroxyacylsphingosi ( 541) 1128 266.8 1.2e-70 NP_003351 (OMIM: 601291) 2-hydroxyacylsphingosine ( 541) 1128 266.8 1.2e-70 XP_016863150 (OMIM: 603064) PREDICTED: UDP-glucuro ( 280) 1123 265.4 1.6e-70 XP_016863149 (OMIM: 603064) PREDICTED: UDP-glucuro ( 280) 1123 265.4 1.6e-70 XP_011530531 (OMIM: 600068) PREDICTED: UDP-glucuro ( 450) 1047 248.3 3.8e-65 NP_001239204 (OMIM: 604716) UDP-glucuronosyltransf ( 527) 1047 248.3 4.3e-65 XP_016863792 (OMIM: 606497) PREDICTED: UDP-glucuro ( 391) 901 214.9 3.5e-55 NP_001288168 (OMIM: 604716) UDP-glucuronosyltransf ( 483) 858 205.2 3.7e-52 NP_001239203 (OMIM: 604716) UDP-glucuronosyltransf ( 693) 858 205.3 5e-52 NP_777574 (OMIM: 616384) UDP-glucuronosyltransfera ( 523) 838 200.7 9.4e-51 NP_689617 (OMIM: 616383) UDP-glucuronosyltransfera ( 523) 818 196.1 2.2e-49 XP_016864639 (OMIM: 616384) PREDICTED: UDP-glucuro ( 485) 799 191.7 4.2e-48 NP_001161788 (OMIM: 616384) UDP-glucuronosyltransf ( 489) 799 191.7 4.2e-48 XP_011512290 (OMIM: 616384) PREDICTED: UDP-glucuro ( 550) 799 191.8 4.6e-48 XP_005248300 (OMIM: 616383) PREDICTED: UDP-glucuro ( 469) 773 185.8 2.5e-46 XP_011512261 (OMIM: 616383) PREDICTED: UDP-glucuro ( 469) 773 185.8 2.5e-46 XP_011512260 (OMIM: 616383) PREDICTED: UDP-glucuro ( 489) 773 185.8 2.6e-46 XP_011512259 (OMIM: 616383) PREDICTED: UDP-glucuro ( 492) 773 185.8 2.6e-46 XP_011512263 (OMIM: 616383) PREDICTED: UDP-glucuro ( 410) 771 185.3 3.1e-46 NP_001317648 (OMIM: 600068) UDP-glucuronosyltransf ( 369) 757 182.1 2.6e-45 NP_001284544 (OMIM: 600067) UDP-glucuronosyltransf ( 369) 739 178.0 4.4e-44 >>NP_061950 (OMIM: 606432) UDP-glucuronosyltransferase 1 (530 aa) initn: 3606 init1: 3606 opt: 3606 Z-score: 4442.9 bits: 831.8 E(85289): 0 Smith-Waterman score: 3606; 100.0% identity (100.0% similar) in 530 aa overlap (1-530:1-530) 10 20 30 40 50 60 pF1KE0 MARAGWTGLLPLYVCLLLTCGFAKAGKLLVVPMDGSHWFTMQSVVEKLILRGHEVVVVMP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 MARAGWTGLLPLYVCLLLTCGFAKAGKLLVVPMDGSHWFTMQSVVEKLILRGHEVVVVMP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 EVSWQLGRSLNCTVKTYSTSYTLEDQDREFMVFADARWTAPLRSAFSLLTSSSNGIFDLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 EVSWQLGRSLNCTVKTYSTSYTLEDQDREFMVFADARWTAPLRSAFSLLTSSSNGIFDLF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 FSNCRSLFNDRKLVEYLKESCFDAVFLDPFDACGLIVAKYFSLPSVVFARGIFCHYLEEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 FSNCRSLFNDRKLVEYLKESCFDAVFLDPFDACGLIVAKYFSLPSVVFARGIFCHYLEEG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 AQCPAPLSYVPRLLLGFSDAMTFKERVWNHIMHLEEHLFCPYFFKNVLEIASEILQTPVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 AQCPAPLSYVPRLLLGFSDAMTFKERVWNHIMHLEEHLFCPYFFKNVLEIASEILQTPVT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 AYDLYSHTSIWLLRTDFVLEYPKPVMPNMIFIGGINCHQGKPVPMEFEAYINASGEHGIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 AYDLYSHTSIWLLRTDFVLEYPKPVMPNMIFIGGINCHQGKPVPMEFEAYINASGEHGIV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 VFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 VFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGH 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 PMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 PMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE0 ENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 ENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTW 430 440 450 460 470 480 490 500 510 520 530 pF1KE0 YQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH :::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 YQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH 490 500 510 520 530 >>NP_061949 (OMIM: 606433) UDP-glucuronosyltransferase 1 (530 aa) initn: 3387 init1: 3387 opt: 3387 Z-score: 4173.0 bits: 781.8 E(85289): 0 Smith-Waterman score: 3387; 94.5% identity (97.4% similar) in 530 aa overlap (1-530:1-530) 10 20 30 40 50 60 pF1KE0 MARAGWTGLLPLYVCLLLTCGFAKAGKLLVVPMDGSHWFTMQSVVEKLILRGHEVVVVMP :::.:::. .:: : ::::::::.:::::::::::::::::::::::::::::::::::: NP_061 MARTGWTSPIPLCVSLLLTCGFAEAGKLLVVPMDGSHWFTMQSVVEKLILRGHEVVVVMP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 EVSWQLGRSLNCTVKTYSTSYTLEDQDREFMVFADARWTAPLRSAFSLLTSSSNGIFDLF :::::::.::::::::::::::::: ::::: ::::.: : .:: :::. :::::.:.:: NP_061 EVSWQLGKSLNCTVKTYSTSYTLEDLDREFMDFADAQWKAQVRSLFSLFLSSSNGFFNLF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 FSNCRSLFNDRKLVEYLKESCFDAVFLDPFDACGLIVAKYFSLPSVVFARGIFCHYLEEG ::.::::::::::::::::: ::::::::::::::::::::::::::::::: ::::::: NP_061 FSHCRSLFNDRKLVEYLKESSFDAVFLDPFDACGLIVAKYFSLPSVVFARGIACHYLEEG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 AQCPAPLSYVPRLLLGFSDAMTFKERVWNHIMHLEEHLFCPYFFKNVLEIASEILQTPVT ::::::::::::.:::::::::::::: :::::::::::: :: ::.::::::::::::: NP_061 AQCPAPLSYVPRILLGFSDAMTFKERVRNHIMHLEEHLFCQYFSKNALEIASEILQTPVT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 AYDLYSHTSIWLLRTDFVLEYPKPVMPNMIFIGGINCHQGKPVPMEFEAYINASGEHGIV :::::::::::::::::::.::::::::::::::::::::::.::::::::::::::::: NP_061 AYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGINCHQGKPLPMEFEAYINASGEHGIV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 VFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 VFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGH 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 PMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 PMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE0 ENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 ENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTW 430 440 450 460 470 480 490 500 510 520 530 pF1KE0 YQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH :::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 YQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH 490 500 510 520 530 >>NP_061948 (OMIM: 606435) UDP-glucuronosyltransferase 1 (530 aa) initn: 3380 init1: 3380 opt: 3380 Z-score: 4164.4 bits: 780.2 E(85289): 0 Smith-Waterman score: 3380; 93.8% identity (97.5% similar) in 530 aa overlap (1-530:1-530) 10 20 30 40 50 60 pF1KE0 MARAGWTGLLPLYVCLLLTCGFAKAGKLLVVPMDGSHWFTMQSVVEKLILRGHEVVVVMP :::::::. .:: ::::::::::.:::::::::::::::::::::::::::::::::::: NP_061 MARAGWTSPVPLCVCLLLTCGFAEAGKLLVVPMDGSHWFTMQSVVEKLILRGHEVVVVMP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 EVSWQLGRSLNCTVKTYSTSYTLEDQDREFMVFADARWTAPLRSAFSLLTSSSNGIFDLF :::::: :::::::::::::::::::.::::::: :.: : .: :::: :::.:..::: NP_061 EVSWQLERSLNCTVKTYSTSYTLEDQNREFMVFAHAQWKAQAQSIFSLLMSSSSGFLDLF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 FSNCRSLFNDRKLVEYLKESCFDAVFLDPFDACGLIVAKYFSLPSVVFARGIFCHYLEEG ::.::::::::::::::::: ::::::::::.::::::::::::::::.::::::.:::: NP_061 FSHCRSLFNDRKLVEYLKESSFDAVFLDPFDTCGLIVAKYFSLPSVVFTRGIFCHHLEEG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 AQCPAPLSYVPRLLLGFSDAMTFKERVWNHIMHLEEHLFCPYFFKNVLEIASEILQTPVT ::::::::::: ::::::::::::::::::.:::.:::: :.:.:.::::::::::::: NP_061 AQCPAPLSYVPNDLLGFSDAMTFKERVWNHIVHLEDHLFCQYLFRNALEIASEILQTPVT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 AYDLYSHTSIWLLRTDFVLEYPKPVMPNMIFIGGINCHQGKPVPMEFEAYINASGEHGIV :::::::::::::::::::.::::::::::::::::::::::.::::::::::::::::: NP_061 AYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGINCHQGKPLPMEFEAYINASGEHGIV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 VFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 VFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGH 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 PMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 PMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE0 ENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 ENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTW 430 440 450 460 470 480 490 500 510 520 530 pF1KE0 YQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH :::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 YQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH 490 500 510 520 530 >>NP_066307 (OMIM: 606434) UDP-glucuronosyltransferase 1 (530 aa) initn: 3349 init1: 3349 opt: 3349 Z-score: 4126.2 bits: 773.2 E(85289): 0 Smith-Waterman score: 3349; 93.4% identity (96.6% similar) in 530 aa overlap (1-530:1-530) 10 20 30 40 50 60 pF1KE0 MARAGWTGLLPLYVCLLLTCGFAKAGKLLVVPMDGSHWFTMQSVVEKLILRGHEVVVVMP :: .:::. ::: ::::::::::.:::::::::::::::::.:::::::::::::::::: NP_066 MACTGWTSPLPLCVCLLLTCGFAEAGKLLVVPMDGSHWFTMRSVVEKLILRGHEVVVVMP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 EVSWQLGRSLNCTVKTYSTSYTLEDQDREFMVFADARWTAPLRSAFSLLTSSSNGIFDLF ::::::::::::::::::::::::: :::: .:: :.: : .:: .::: .: : ::::: NP_066 EVSWQLGRSLNCTVKTYSTSYTLEDLDREFKAFAHAQWKAQVRSIYSLLMGSYNDIFDLF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 FSNCRSLFNDRKLVEYLKESCFDAVFLDPFDACGLIVAKYFSLPSVVFARGIFCHYLEEG ::::::::.:.::::::::: :::::::::: ::::::::::::::::::::.::::::: NP_066 FSNCRSLFKDKKLVEYLKESSFDAVFLDPFDNCGLIVAKYFSLPSVVFARGILCHYLEEG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 AQCPAPLSYVPRLLLGFSDAMTFKERVWNHIMHLEEHLFCPYFFKNVLEIASEILQTPVT ::::::::::::.:::::::::::::: ::::::::::.: ::::.::::::::::::: NP_066 AQCPAPLSYVPRILLGFSDAMTFKERVRNHIMHLEEHLLCHRFFKNALEIASEILQTPVT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 AYDLYSHTSIWLLRTDFVLEYPKPVMPNMIFIGGINCHQGKPVPMEFEAYINASGEHGIV ::::::::::::::::::.::::::::::::::::::::::.::::::::::::::::: NP_066 EYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGINCHQGKPLPMEFEAYINASGEHGIV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 VFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_066 VFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGH 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 PMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_066 PMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE0 ENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_066 ENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTW 430 440 450 460 470 480 490 500 510 520 530 pF1KE0 YQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH :::::::::::::::::::::::::::::::::::::::::::::::::: NP_066 YQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH 490 500 510 520 530 >>NP_001063 (OMIM: 606431) UDP-glucuronosyltransferase 1 (532 aa) initn: 2391 init1: 2194 opt: 2384 Z-score: 2937.1 bits: 553.1 E(85289): 7.4e-157 Smith-Waterman score: 2384; 70.2% identity (84.4% similar) in 520 aa overlap (14-530:15-532) 10 20 30 40 50 pF1KE0 MARAGWTGLLPLYVCLLLTCGFAKAGKLLVVPMDGSHWFTMQSVVEKLILRGHEVVVVM : .: :.. . ::::::.:::::..:...:: : ::::.:::. NP_001 MACLLRSFQRISAGVFFLALWGMVVGDKLLVVPQDGSHWLSMKDIVEVLSDRGHEIVVVV 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE0 PEVSWQLGRSLNCTVKTYSTSYTLEDQDREFMVFADARWTA-PLRSAFSLLTSSSNGIFD :::. : .: : : : . : :. ... :.. ... . .: . .. .. NP_001 PEVNLLLKESKYYTRKIYPVPYDQEELKNRYQSFGNNHFAERSFLTAPQTEYRNNMIVIG 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE0 LFFSNCRSLFNDRKLVEYLKESCFDAVFLDPFDACGLIVAKYFSLPSVVFARGIFCHYLE :.: ::.::..:: ....::: :::.: :: ::.:.:.:..:::: . ::. : . NP_001 LYFINCQSLLQDRDTLNFFKESKFDALFTDPALPCGVILAEYLGLPSVYLFRGFPCSLEH 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE0 EGAQCPAPLSYVPRLLLGFSDAMTFKERVWNHIMHL-EEHLF-CPYFFKNVLEIASEILQ .. : :.::.:: ::: :::..:: : ...: : .:: : .:.. :.:: .:. NP_001 TFSRSPDPVSYIPRCYTKFSDHMTFSQRVANFLVNLLEPYLFYC--LFSKYEELASAVLK 190 200 210 220 230 240 250 260 270 280 290 pF1KE0 TPVTAYDLYSHTSIWLLRTDFVLEYPKPVMPNMIFIGGINCHQGKPVPMEFEAYINASGE : ::...:.:::: :::::::.::::::.:::::::.. : . .::::::::::: NP_001 RDVDIITLYQKVSVWLLRYDFVLEYPRPVMPNMVFIGGINCKKRKDLSQEFEAYINASGE 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE0 HGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQND 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE0 LLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMT 360 370 380 390 400 410 420 430 440 450 460 470 pF1KE0 SEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAH 420 430 440 450 460 470 480 490 500 510 520 530 pF1KE0 DLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH 480 490 500 510 520 530 >>NP_061966 (OMIM: 606428) UDP-glucuronosyltransferase 1 (534 aa) initn: 2374 init1: 2181 opt: 2368 Z-score: 2917.4 bits: 549.5 E(85289): 9.3e-156 Smith-Waterman score: 2368; 67.9% identity (83.0% similar) in 529 aa overlap (6-530:11-534) 10 20 30 40 50 pF1KE0 MARAGW--TGLLPLYVCLLLTCG-FAKAGKLLVVPMDGSHWFTMQSVVEKLILRG : :::: :::. .:..::.::::.:::::..:. :...: :: NP_061 MATGLQVPLPWLATGLL-----LLLSVQPWAESGKVLVVPIDGSHWLSMREVLRELHARG 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 HEVVVVMPEVSWQLGRSLNCTVKTYSTSYTLEDQDREFMVFADARW-TAPLRSAFSLLTS :..::. :::. .. . :. ::. :.: .. ::. . .. . : . . : . NP_061 HQAVVLTPEVNMHIKEENFFTLTTYAISWTQDEFDRHVLGHTQLYFETEHFLKKFFRSMA 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 SSNGIFDLFFSNCRSLFNDRKLVEYLKESCFDAVFLDPFDACGLIVAKYFSLPSVVFARG :.. .. .: :.... :...:. . ::.:. :: . :. ..:::.:.:.: : :. NP_061 MLNNMSLVYHRSCVELLHNEALIRHLNATSFDVVLTDPVNLCAAVLAKYLSIPTVFFLRN 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE0 IFCHYLEEGAQCPAPLSYVPRLLLGFSDAMTFKERVWNHIMHLEEHLFCPYFFKNVLEIA : : .:.::: : ::.:::: :: ::: .:: : .. : .: : .: NP_061 IPCDLDFKGTQCPNPSSYIPRLLTTNSDHMTFMQRVKNMLYPLALSYICHAFSAPYASLA 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE0 SEILQTPVTAYDLYSHTSIWLLRTDFVLEYPKPVMPNMIFIGGINCHQGKPVPMEFEAYI ::..: :.. :. ::.:.::.: :::..::.:.::::.::::::: . ::. .:::::: NP_061 SELFQREVSVVDILSHASVWLFRGDFVMDYPRPIMPNMVFIGGINCANRKPLSQEFEAYI 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE0 NASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 NASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKW 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE0 LPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 LPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLN 360 370 380 390 400 410 420 430 440 450 460 470 pF1KE0 VLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 VLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHL 420 430 440 450 460 470 480 490 500 510 520 530 pF1KE0 RPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 RPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH 480 490 500 510 520 530 >>NP_061951 (OMIM: 606430) UDP-glucuronosyltransferase 1 (534 aa) initn: 2359 init1: 2188 opt: 2363 Z-score: 2911.2 bits: 548.4 E(85289): 2e-155 Smith-Waterman score: 2363; 68.6% identity (82.7% similar) in 525 aa overlap (7-530:14-534) 10 20 30 40 50 pF1KE0 MARAGWTGLLPLYVCLLLTCGFAKAGKLLVVPMDGSHWFTMQSVVEKLILRGH :::: :: . .:..::.:::: :::::..:. ... : ::: NP_061 MATGLQVPLPQLATGLL----LLLSVQPWAESGKVLVVPTDGSHWLSMREALRDLHARGH 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 EVVVVMPEVSWQLGRSLNCTVKTYSTSYTLEDQDREFMVFADARW-TAPLRSAFSLLTSS .:::. ::. . . :. ::. :.: .. :: .. ... . : : :: . NP_061 QVVVLTLEVNMYIKEENFFTLTTYAISWTQDEFDRLLLGHTQSFFETEHLLMKFSRRMAI 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 SNGIFDLFFSNCRSLFNDRKLVEYLKESCFDAVFLDPFDACGLIVAKYFSLPSVVFARGI :.. .. .: :.... :...:. . ::.:. ::: :. ..:::.:.:.: : :.: NP_061 MNNMSLIIHRSCVELLHNEALIRHLHATSFDVVLTDPFHLCAAVLAKYLSIPAVFFLRNI 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE0 FCHYLEEGAQCPAPLSYVPRLLLGFSDAMTFKERVWNHIMHLEEHLFCPYFFKNVLEIAS : .:.::: : ::.:::: :: ::: .:: : .. : .: .:: NP_061 PCDLDFKGTQCPNPSSYIPRLLTTNSDHMTFLQRVKNMLYPLALSYLCHAVSAPYASLAS 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE0 EILQTPVTAYDLYSHTSIWLLRTDFVLEYPKPVMPNMIFIGGINCHQGKPVPMEFEAYIN :..: :.. :: ::.:.::.: :::..::.:.::::.::::::: .:::. .::::::: NP_061 ELFQREVSVVDLVSHASVWLFRGDFVMDYPRPIMPNMVFIGGINCANGKPLSQEFEAYIN 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE0 ASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 ASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWL 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE0 PQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 PQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNV 360 370 380 390 400 410 420 430 440 450 460 470 pF1KE0 LEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 LEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLR 420 430 440 450 460 470 480 490 500 510 520 530 pF1KE0 PAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 PAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH 480 490 500 510 520 530 >>NP_000454 (OMIM: 143500,191740,218800,237900,601816,60 (533 aa) initn: 2360 init1: 2181 opt: 2357 Z-score: 2903.8 bits: 547.0 E(85289): 5.3e-155 Smith-Waterman score: 2357; 66.3% identity (83.1% similar) in 534 aa overlap (2-530:5-533) 10 20 30 40 50 pF1KE0 MARAGWTGLLPLYVCLLLTCGFAKAGKLLVVPMDGSHWFTMQSVVEKLILRGHEVVV ...: .: : .:.: ..:::.:..:.:::::..: .....: ::::.:: NP_000 MAVESQGGRPLVLGLLLCVLGPV-VSHAGKILLIPVDGSHWLSMLGAIQQLQQRGHEIVV 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 VMPEVSWQLGRSLNCTVKTYSTSYTLEDQDREFM-----VFADARWTAPLRSAFSLLTSS . :..: . . :.::: . . :: . :. :: . . . .... . .. NP_000 LAPDASLYIRDGAFYTLKTYPVPFQREDVKESFVSLGHNVFENDSFLQRVIKTYKKIKKD 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 SNGIFDLFFSNCRSLFNDRKLVEYLKESCFDAVFLDPFDACGLIVAKYFSLPSVVFARGI : ...:.: :.....:. : :: ::... ::: :. :::.:.:::.: : ... NP_000 SA----MLLSGCSHLLHNKELMASLAESSFDVMLTDPFLPCSPIVAQYLSLPTVFFLHAL 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE0 FCHYLEEGAQCPAPLSYVPRLLLGFSDAMTFKERVWNHIMHLEEHLFCPYFFKNVLEIAS : :..::: :.::::: : . :: ::: .:: : .. . ....: .. .:: NP_000 PCSLEFEATQCPNPFSYVPRPLSSHSDHMTFLQRVKNMLIAFSQNFLCDVVYSPYATLAS 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE0 EILQTPVTAYDLYSHTSIWLLRTDFVLEYPKPVMPNMIFIGGINCHQGKPVPMEFEAYIN :.:: ::. :: : .:.::.:.::: .::.:.::::.:.::::: . .:. .::::::: NP_000 EFLQREVTVQDLLSSASVWLFRSDFVKDYPRPIMPNMVFVGGINCLHQNPLSQEFEAYIN 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE0 ASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 ASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWL 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE0 PQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 PQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNV 360 370 380 390 400 410 420 430 440 450 460 470 pF1KE0 LEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 LEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLR 420 430 440 450 460 470 480 490 500 510 520 530 pF1KE0 PAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 PAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH 480 490 500 510 520 530 >>NP_009051 (OMIM: 606429) UDP-glucuronosyltransferase 1 (534 aa) initn: 2342 init1: 2181 opt: 2343 Z-score: 2886.5 bits: 543.8 E(85289): 4.8e-154 Smith-Waterman score: 2343; 66.9% identity (82.4% similar) in 534 aa overlap (1-530:1-534) 10 20 30 40 50 pF1KE0 MARAGWTGLLPLYVCLLLTCG---FAKAGKLLVVPMDGSHWFTMQSVVEKLILRGHEVVV :::. . : : . ::: . .:..::.:::: ::: :..:. ....: :::..:: NP_009 MARGLQVPLPRLATGLLLLLSVQPWAESGKVLVVPTDGSPWLSMREALRELHARGHQAVV 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE0 VMPEVSWQLGRSLNCTVKTYSTSYTLEDQDREFMVFADARW-TAPLRSAFSLLTSSSNGI . :::. .. . :. .:.. .: .. :: . .... . : : . .: . :.. NP_009 LTPEVNMHIKEEKFFTLTAYAVPWTQKEFDRVTLGYTQGFFETEHLLKRYSRSMAIMNNV 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE0 FDLFFSNCRSLFNDRKLVEYLKESCFDAVFLDPFDACGLIVAKYFSLPSVVFARGIFCHY . : :.... :...:. . ::.:. :: . :: ..:::.:.:.: : : : : NP_009 SLALHRCCVELLHNEALIRHLNATSFDVVLTDPVNLCGAVLAKYLSIPAVFFWRYIPCDL 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE0 LEEGAQCPAPLSYVPRLLLGFSDAMTFKERVWNHIMHLEEHLFCPYFFKNVLEIASEILQ .:.::: : ::.:.:: :: ::: .:: : .. : .: : .:::..: NP_009 DFKGTQCPNPSSYIPKLLTTNSDHMTFLQRVKNMLYPLALSYICHTFSAPYASLASELFQ 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE0 TPVTAYDLYSHTSIWLLRTDFVLEYPKPVMPNMIFIGGINCHQGKPVPMEFEAYINASGE :.. :: :..:.::.: :::..::.:.::::.::::::: .:::. .::::::::::: NP_009 REVSVVDLVSYASVWLFRGDFVMDYPRPIMPNMVFIGGINCANGKPLSQEFEAYINASGE 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE0 HGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 HGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQND 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE0 LLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 LLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMT 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE0 SEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 SEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAH 430 440 450 460 470 480 480 490 500 510 520 530 pF1KE0 DLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 DLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH 490 500 510 520 530 >>NP_995584 (OMIM: 606431) UDP-glucuronosyltransferase 1 (265 aa) initn: 1736 init1: 1736 opt: 1736 Z-score: 2142.9 bits: 405.2 E(85289): 1.3e-112 Smith-Waterman score: 1736; 97.0% identity (98.9% similar) in 265 aa overlap (266-530:1-265) 240 250 260 270 280 290 pF1KE0 QTPVTAYDLYSHTSIWLLRTDFVLEYPKPVMPNMIFIGGINCHQGKPVPMEFEAYINASG ::::.:::::::.. : . .:::::::::: NP_995 MPNMVFIGGINCKKRKDLSQEFEAYINASG 10 20 30 300 310 320 330 340 350 pF1KE0 EHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_995 EHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQN 40 50 60 70 80 90 360 370 380 390 400 410 pF1KE0 DLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_995 DLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEM 100 110 120 130 140 150 420 430 440 450 460 470 pF1KE0 TSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_995 TSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAA 160 170 180 190 200 210 480 490 500 510 520 530 pF1KE0 HDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_995 HDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH 220 230 240 250 260 530 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 14:01:02 2016 done: Thu Nov 3 14:01:03 2016 Total Scan time: 8.410 Total Display time: 0.110 Function used was FASTA [36.3.4 Apr, 2011]