Result of FASTA (omim) for
pF1KE0365
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0365, 520 aa
1>>>pF1KE0365 520 - 520 aa - 520 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.9581+/-0.000372; mu= 20.3500+/- 0.023
mean_var=63.5651+/-13.195, 0's: 0 Z-trim(113.8): 179 B-trim: 826 in 1/53
Lambda= 0.160866
statistics sampled from 23185 (23371) to 23185 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.642), E-opt: 0.2 (0.274), width: 16
Scan time: 8.720
The best scores are: opt bits E(85289)
NP_009184 (OMIM: 611545) cytochrome P450 4F8 precu ( 520) 3586 841.1 0
NP_001073 (OMIM: 604426) phylloquinone omega-hydro ( 520) 3000 705.1 1.3e-202
XP_016882303 (OMIM: 601270) PREDICTED: docosahexae ( 520) 2979 700.2 3.8e-201
NP_001186137 (OMIM: 601270) docosahexaenoic acid o ( 520) 2979 700.2 3.8e-201
NP_001186138 (OMIM: 601270) docosahexaenoic acid o ( 520) 2979 700.2 3.8e-201
NP_001122404 (OMIM: 611517) phylloquinone omega-hy ( 524) 2912 684.6 1.8e-196
NP_067010 (OMIM: 611517) phylloquinone omega-hydro ( 524) 2912 684.6 1.8e-196
NP_076433 (OMIM: 611485) cytochrome P450 4F12 [Hom ( 524) 2864 673.5 4.2e-193
XP_016881721 (OMIM: 611545) PREDICTED: cytochrome ( 418) 2857 671.8 1.1e-192
NP_000887 (OMIM: 601270) docosahexaenoic acid omeg ( 520) 2801 658.9 1e-188
XP_011525994 (OMIM: 611495) PREDICTED: cytochrome ( 531) 2249 530.8 3.9e-150
NP_775754 (OMIM: 611495) cytochrome P450 4F22 [Hom ( 531) 2249 530.8 3.9e-150
XP_011525995 (OMIM: 611495) PREDICTED: cytochrome ( 531) 2249 530.8 3.9e-150
XP_011526316 (OMIM: 601270) PREDICTED: docosahexae ( 371) 2172 512.8 7e-145
XP_005259968 (OMIM: 601270) PREDICTED: docosahexae ( 371) 2172 512.8 7e-145
XP_016882304 (OMIM: 601270) PREDICTED: docosahexae ( 391) 2095 495.0 1.8e-139
XP_006722913 (OMIM: 611485) PREDICTED: cytochrome ( 375) 2089 493.5 4.4e-139
XP_011526504 (OMIM: 611485) PREDICTED: cytochrome ( 375) 2089 493.5 4.4e-139
XP_011526510 (OMIM: 611485) PREDICTED: cytochrome ( 375) 2089 493.5 4.4e-139
XP_016882661 (OMIM: 611485) PREDICTED: cytochrome ( 411) 2011 475.5 1.3e-133
XP_011526506 (OMIM: 611485) PREDICTED: cytochrome ( 352) 1957 462.9 7.1e-130
XP_011526507 (OMIM: 611485) PREDICTED: cytochrome ( 352) 1957 462.9 7.1e-130
XP_011526505 (OMIM: 611485) PREDICTED: cytochrome ( 352) 1957 462.9 7.1e-130
XP_011526509 (OMIM: 611485) PREDICTED: cytochrome ( 334) 1891 447.6 2.8e-125
NP_000769 (OMIM: 601310) cytochrome P450 4A11 isof ( 519) 1428 340.2 8.7e-93
NP_001093242 (OMIM: 124075) cytochrome P450 4B1 is ( 512) 1413 336.8 9.6e-92
NP_000770 (OMIM: 124075) cytochrome P450 4B1 isofo ( 511) 1406 335.1 3e-91
XP_016855954 (OMIM: 601310) PREDICTED: cytochrome ( 415) 1353 322.8 1.3e-87
NP_001010969 (OMIM: 615341) cytochrome P450 4A22 i ( 519) 1352 322.6 1.8e-87
XP_016855955 (OMIM: 124075) PREDICTED: cytochrome ( 496) 1339 319.6 1.4e-86
NP_828847 (OMIM: 614999) cytochrome P450 4X1 isofo ( 509) 1332 318.0 4.4e-86
NP_001306090 (OMIM: 124075) cytochrome P450 4B1 is ( 497) 1329 317.2 6.9e-86
NP_001307218 (OMIM: 614999) cytochrome P450 4X1 is ( 508) 1298 310.1 1e-83
NP_001307219 (OMIM: 614999) cytochrome P450 4X1 is ( 444) 1294 309.1 1.8e-83
XP_016856462 (OMIM: 614999) PREDICTED: cytochrome ( 470) 1237 295.9 1.8e-79
NP_001306092 (OMIM: 124075) cytochrome P450 4B1 is ( 348) 1165 279.1 1.5e-74
NP_001306091 (OMIM: 124075) cytochrome P450 4B1 is ( 349) 1155 276.8 7.5e-74
NP_997235 (OMIM: 210370,608614) cytochrome P450 4V ( 525) 1045 251.4 5e-66
XP_005262992 (OMIM: 210370,608614) PREDICTED: cyto ( 524) 1034 248.8 3e-65
NP_001306084 (OMIM: 601310) cytochrome P450 4A11 i ( 487) 978 235.8 2.3e-61
XP_016863526 (OMIM: 210370,608614) PREDICTED: cyto ( 393) 890 215.3 2.7e-55
XP_011539135 (OMIM: 124075) PREDICTED: cytochrome ( 278) 845 204.8 2.8e-52
NP_001278759 (OMIM: 145500,605325) cytochrome P450 ( 492) 588 145.3 4e-34
NP_000768 (OMIM: 145500,605325) cytochrome P450 3A ( 502) 588 145.3 4.1e-34
NP_073731 (OMIM: 606534) cytochrome P450 3A43 isof ( 504) 579 143.2 1.8e-33
XP_011539134 (OMIM: 124075) PREDICTED: cytochrome ( 296) 576 142.3 1.9e-33
NP_476436 (OMIM: 606534) cytochrome P450 3A43 isof ( 503) 574 142.0 3.9e-33
XP_016868031 (OMIM: 606534) PREDICTED: cytochrome ( 394) 562 139.2 2.2e-32
XP_016868032 (OMIM: 606534) PREDICTED: cytochrome ( 394) 562 139.2 2.2e-32
NP_000756 (OMIM: 605340) cytochrome P450 3A7 [Homo ( 503) 562 139.2 2.7e-32
>>NP_009184 (OMIM: 611545) cytochrome P450 4F8 precursor (520 aa)
initn: 3586 init1: 3586 opt: 3586 Z-score: 4493.5 bits: 841.1 E(85289): 0
Smith-Waterman score: 3586; 100.0% identity (100.0% similar) in 520 aa overlap (1-520:1-520)
10 20 30 40 50 60
pF1KE0 MSLLSLSWLGLRPVAASPWLLLLVVGASWLLARILAWTYAFYHNGRRLRCFPQPRKQNWF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 MSLLSLSWLGLRPVAASPWLLLLVVGASWLLARILAWTYAFYHNGRRLRCFPQPRKQNWF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 LGHLGLVTPTEEGLRVLTQLVATYPQGFVRWLGPITPIINLCHPDIVRSVINTSDAITDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 LGHLGLVTPTEEGLRVLTQLVATYPQGFVRWLGPITPIINLCHPDIVRSVINTSDAITDK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 DIVFYKTLKPWLGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 DIVFYKTLKPWLGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 LAMEGSTCLDVFEHISLMTLDSLQKCIFSFDSNCQEKPSEYITAIMELSALVVKRNNQFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 LAMEGSTCLDVFEHISLMTLDSLQKCIFSFDSNCQEKPSEYITAIMELSALVVKRNNQFF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 RYKDFLYFLTPCGRRFHRACRLVHDFTDAVIQERRRTLTSQGVDDFLQAKAKSKTLDFID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 RYKDFLYFLTPCGRRFHRACRLVHDFTDAVIQERRRTLTSQGVDDFLQAKAKSKTLDFID
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 VLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 VLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 LLKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 LLKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVC
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE0 NINIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_009 NINIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKV
430 440 450 460 470 480
490 500 510 520
pF1KE0 VLALTLLRFRILPDHREPRRTPEIVLRAEDGLWLRVEPLG
::::::::::::::::::::::::::::::::::::::::
NP_009 VLALTLLRFRILPDHREPRRTPEIVLRAEDGLWLRVEPLG
490 500 510 520
>>NP_001073 (OMIM: 604426) phylloquinone omega-hydroxyla (520 aa)
initn: 3000 init1: 3000 opt: 3000 Z-score: 3758.5 bits: 705.1 E(85289): 1.3e-202
Smith-Waterman score: 3000; 81.3% identity (93.6% similar) in 519 aa overlap (1-519:1-519)
10 20 30 40 50 60
pF1KE0 MSLLSLSWLGLRPVAASPWLLLLVVGASWLLARILAWTYAFYHNGRRLRCFPQPRKQNWF
:: :::::::: :::::::::::.::::::::..:::::::: : ::::::::: ..:::
NP_001 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 LGHLGLVTPTEEGLRVLTQLVATYPQGFVRWLGPITPIINLCHPDIVRSVINTSDAITDK
:: :.:.:::::.:::::::::::::: :.:::.:...::::::.:::::.: ::. :
NP_001 WGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 DIVFYKTLKPWLGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQR
: ::. :.::::::::::.:::: .:::.:::::::::::::.:::..:.::::::::
NP_001 DKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 LAMEGSTCLDVFEHISLMTLDSLQKCIFSFDSNCQEKPSEYITAIMELSALVVKRNNQFF
:: :::.:::.:::::::::::::::.:::::.:::::::::.::.:::::: ::.....
NP_001 LASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEIL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 RYKDFLYFLTPCGRRFHRACRLVHDFTDAVIQERRRTLTSQGVDDFLQAKAKSKTLDFID
. ::::.::: :.::.::::::::::::::::::::: :::::::::::::::::::::
NP_001 LHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFID
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 VLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQE
:::::.:..::.::::::::::::::: ::::::::::::::.::.::::::::::::::
NP_001 VLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 LLKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVC
::::::::::::::::.:::::::.:::::::::.:...: :::.::::.:::::: .:
NP_001 LLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIIC
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE0 NINIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKV
:..:. ::::.::::::::::::::::: ..:::.::::::::::::::: ::::::::
NP_001 LISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKV
430 440 450 460 470 480
490 500 510 520
pF1KE0 VLALTLLRFRILPDHREPRRTPEIVLRAEDGLWLRVEPLG
::::::::::.:::: :::: ::.::::: :::::::::
NP_001 VLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS
490 500 510 520
>>XP_016882303 (OMIM: 601270) PREDICTED: docosahexaenoic (520 aa)
initn: 2979 init1: 2979 opt: 2979 Z-score: 3732.1 bits: 700.2 E(85289): 3.8e-201
Smith-Waterman score: 2979; 81.7% identity (93.3% similar) in 519 aa overlap (1-519:1-519)
10 20 30 40 50 60
pF1KE0 MSLLSLSWLGLRPVAASPWLLLLVVGASWLLARILAWTYAFYHNGRRLRCFPQPRKQNWF
: :::: ::: :.:::::::::.:::::::::::::::.:: : :::::::: :.:::
XP_016 MPQLSLSSLGLWPMAASPWLLLLLVGASWLLARILAWTYTFYDNCCRLRCFPQPPKRNWF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 LGHLGLVTPTEEGLRVLTQLVATYPQGFVRWLGPITPIINLCHPDIVRSVINTSDAITDK
:::::::::::.:.:::::::::::::: :.::: :.: .:::.:.:::::.: ::. :
XP_016 LGHLGLVTPTEQGMRVLTQLVATYPQGFKVWMGPIFPVIRFCHPNIIRSVINASAAIVPK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 DIVFYKTLKPWLGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQR
: :::. ::::::::::::.:.:: .:::.:::::::::::::.:::..:.::::::::
XP_016 DKVFYSFLKPWLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 LAMEGSTCLDVFEHISLMTLDSLQKCIFSFDSNCQEKPSEYITAIMELSALVVKRNNQFF
:: :::. ::.:::::::::::::::.:::::.:::::::::.::.::::::.::..:..
XP_016 LASEGSARLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVTKRHQQIL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 RYKDFLYFLTPCGRRFHRACRLVHDFTDAVIQERRRTLTSQGVDDFLQAKAKSKTLDFID
: ::::.::: :.::.::::::::::::::::::::: :::::::::::::::::::::
XP_016 LYIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFID
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 VLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQE
:::::.:..::.::::::::::::::: ::::::::::::::.::.::::::::::::::
XP_016 VLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 LLKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVC
::::::::::::::::::::::::.:::::::::.:. .: ::::.::::.:::::: .:
XP_016 LLKDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIIC
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE0 NINIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKV
:..:. ::::.:::::::::::::::.: ..:::.::::::::::::::: ::::::::
XP_016 LISVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKV
430 440 450 460 470 480
490 500 510 520
pF1KE0 VLALTLLRFRILPDHREPRRTPEIVLRAEDGLWLRVEPLG
::.:::::::.:::: :::: ::.::::: :::::::::
XP_016 VLGLTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS
490 500 510 520
>>NP_001186137 (OMIM: 601270) docosahexaenoic acid omega (520 aa)
initn: 2979 init1: 2979 opt: 2979 Z-score: 3732.1 bits: 700.2 E(85289): 3.8e-201
Smith-Waterman score: 2979; 81.7% identity (93.3% similar) in 519 aa overlap (1-519:1-519)
10 20 30 40 50 60
pF1KE0 MSLLSLSWLGLRPVAASPWLLLLVVGASWLLARILAWTYAFYHNGRRLRCFPQPRKQNWF
: :::: ::: :.:::::::::.:::::::::::::::.:: : :::::::: :.:::
NP_001 MPQLSLSSLGLWPMAASPWLLLLLVGASWLLARILAWTYTFYDNCCRLRCFPQPPKRNWF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 LGHLGLVTPTEEGLRVLTQLVATYPQGFVRWLGPITPIINLCHPDIVRSVINTSDAITDK
:::::::::::.:.:::::::::::::: :.::: :.: .:::.:.:::::.: ::. :
NP_001 LGHLGLVTPTEQGMRVLTQLVATYPQGFKVWMGPIFPVIRFCHPNIIRSVINASAAIVPK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 DIVFYKTLKPWLGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQR
: :::. ::::::::::::.:.:: .:::.:::::::::::::.:::..:.::::::::
NP_001 DKVFYSFLKPWLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 LAMEGSTCLDVFEHISLMTLDSLQKCIFSFDSNCQEKPSEYITAIMELSALVVKRNNQFF
:: :::. ::.:::::::::::::::.:::::.:::::::::.::.::::::.::..:..
NP_001 LASEGSARLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVTKRHQQIL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 RYKDFLYFLTPCGRRFHRACRLVHDFTDAVIQERRRTLTSQGVDDFLQAKAKSKTLDFID
: ::::.::: :.::.::::::::::::::::::::: :::::::::::::::::::::
NP_001 LYIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFID
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 VLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQE
:::::.:..::.::::::::::::::: ::::::::::::::.::.::::::::::::::
NP_001 VLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 LLKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVC
::::::::::::::::::::::::.:::::::::.:. .: ::::.::::.:::::: .:
NP_001 LLKDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIIC
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE0 NINIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKV
:..:. ::::.:::::::::::::::.: ..:::.::::::::::::::: ::::::::
NP_001 LISVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKV
430 440 450 460 470 480
490 500 510 520
pF1KE0 VLALTLLRFRILPDHREPRRTPEIVLRAEDGLWLRVEPLG
::.:::::::.:::: :::: ::.::::: :::::::::
NP_001 VLGLTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS
490 500 510 520
>>NP_001186138 (OMIM: 601270) docosahexaenoic acid omega (520 aa)
initn: 2979 init1: 2979 opt: 2979 Z-score: 3732.1 bits: 700.2 E(85289): 3.8e-201
Smith-Waterman score: 2979; 81.7% identity (93.3% similar) in 519 aa overlap (1-519:1-519)
10 20 30 40 50 60
pF1KE0 MSLLSLSWLGLRPVAASPWLLLLVVGASWLLARILAWTYAFYHNGRRLRCFPQPRKQNWF
: :::: ::: :.:::::::::.:::::::::::::::.:: : :::::::: :.:::
NP_001 MPQLSLSSLGLWPMAASPWLLLLLVGASWLLARILAWTYTFYDNCCRLRCFPQPPKRNWF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 LGHLGLVTPTEEGLRVLTQLVATYPQGFVRWLGPITPIINLCHPDIVRSVINTSDAITDK
:::::::::::.:.:::::::::::::: :.::: :.: .:::.:.:::::.: ::. :
NP_001 LGHLGLVTPTEQGMRVLTQLVATYPQGFKVWMGPIFPVIRFCHPNIIRSVINASAAIVPK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 DIVFYKTLKPWLGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQR
: :::. ::::::::::::.:.:: .:::.:::::::::::::.:::..:.::::::::
NP_001 DKVFYSFLKPWLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 LAMEGSTCLDVFEHISLMTLDSLQKCIFSFDSNCQEKPSEYITAIMELSALVVKRNNQFF
:: :::. ::.:::::::::::::::.:::::.:::::::::.::.::::::.::..:..
NP_001 LASEGSARLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVTKRHQQIL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 RYKDFLYFLTPCGRRFHRACRLVHDFTDAVIQERRRTLTSQGVDDFLQAKAKSKTLDFID
: ::::.::: :.::.::::::::::::::::::::: :::::::::::::::::::::
NP_001 LYIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFID
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 VLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQE
:::::.:..::.::::::::::::::: ::::::::::::::.::.::::::::::::::
NP_001 VLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 LLKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVC
::::::::::::::::::::::::.:::::::::.:. .: ::::.::::.:::::: .:
NP_001 LLKDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIIC
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE0 NINIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKV
:..:. ::::.:::::::::::::::.: ..:::.::::::::::::::: ::::::::
NP_001 LISVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKV
430 440 450 460 470 480
490 500 510 520
pF1KE0 VLALTLLRFRILPDHREPRRTPEIVLRAEDGLWLRVEPLG
::.:::::::.:::: :::: ::.::::: :::::::::
NP_001 VLGLTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS
490 500 510 520
>>NP_001122404 (OMIM: 611517) phylloquinone omega-hydrox (524 aa)
initn: 2912 init1: 2912 opt: 2912 Z-score: 3648.1 bits: 684.6 E(85289): 1.8e-196
Smith-Waterman score: 2912; 79.2% identity (91.5% similar) in 520 aa overlap (1-520:1-520)
10 20 30 40 50 60
pF1KE0 MSLLSLSWLGLRPVAASPWLLLLVVGASWLLARILAWTYAFYHNGRRLRCFPQPRKQNWF
: :::::::: :::::::::::.::.::::::.:::::.:: : :::.::::: :::::
NP_001 MPQLSLSWLGLGPVAASPWLLLLLVGGSWLLARVLAWTYTFYDNCRRLQCFPQPPKQNWF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 LGHLGLVTPTEEGLRVLTQLVATYPQGFVRWLGPITPIINLCHPDIVRSVINTSDAITDK
:: :::::::::...:::::.:::::: :::: :.. ::::::.: . ..: :.. :
NP_001 WGHQGLVTPTEEGMKTLTQLVTTYPQGFKLWLGPTFPLLILCHPDIIRPITSASAAVAPK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 DIVFYKTLKPWLGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQR
:..:: :::::::::::: :::: .:::.:::::::::::::.:::.::.:::: ::::
NP_001 DMIFYGFLKPWLGDGLLLSGGDKWSRHRRMLTPAFHFNILKPYMKIFNKSVNIMHDKWQR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 LAMEGSTCLDVFEHISLMTLDSLQKCIFSFDSNCQEKPSEYITAIMELSALVVKRNNQFF
:: :::. ::.:::::::::::::::.:::.:::::::::::.::.::::.: :::.:..
NP_001 LASEGSARLDMFEHISLMTLDSLQKCVFSFESNCQEKPSEYIAAILELSAFVEKRNQQIL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 RYKDFLYFLTPCGRRFHRACRLVHDFTDAVIQERRRTLTSQGVDDFLQAKAKSKTLDFID
. ::::.::: :.::.:::.:::::::::::::: :: .::.::::. :::::::::::
NP_001 LHTDFLYYLTPDGQRFRRACHLVHDFTDAVIQERRCTLPTQGIDDFLKNKAKSKTLDFID
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 VLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQE
:::::.:..:::::::::::::::::: ::::::::::::::.::.::::::.:::::::
NP_001 VLLLSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 LLKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVC
::::::: ::::::::::::::::.:::::::::.:...: :::: ::::.:::::: ::
NP_001 LLKDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVC
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE0 NINIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKV
:::..::.::.:::::::::::::: :: ..:::.::::::::::::::: ::::::::
NP_001 LINIIGIHYNPTVWPDPEVYDPFRFDQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKV
430 440 450 460 470 480
490 500 510 520
pF1KE0 VLALTLLRFRILPDHREPRRTPEIVLRAEDGLWLRVEPLG
:::::::.::::: : :::: ::..:::: ::::::::::
NP_001 VLALTLLHFRILPTHTEPRRKPELILRAEGGLWLRVEPLGANSQ
490 500 510 520
>>NP_067010 (OMIM: 611517) phylloquinone omega-hydroxyla (524 aa)
initn: 2912 init1: 2912 opt: 2912 Z-score: 3648.1 bits: 684.6 E(85289): 1.8e-196
Smith-Waterman score: 2912; 79.2% identity (91.5% similar) in 520 aa overlap (1-520:1-520)
10 20 30 40 50 60
pF1KE0 MSLLSLSWLGLRPVAASPWLLLLVVGASWLLARILAWTYAFYHNGRRLRCFPQPRKQNWF
: :::::::: :::::::::::.::.::::::.:::::.:: : :::.::::: :::::
NP_067 MPQLSLSWLGLGPVAASPWLLLLLVGGSWLLARVLAWTYTFYDNCRRLQCFPQPPKQNWF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 LGHLGLVTPTEEGLRVLTQLVATYPQGFVRWLGPITPIINLCHPDIVRSVINTSDAITDK
:: :::::::::...:::::.:::::: :::: :.. ::::::.: . ..: :.. :
NP_067 WGHQGLVTPTEEGMKTLTQLVTTYPQGFKLWLGPTFPLLILCHPDIIRPITSASAAVAPK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 DIVFYKTLKPWLGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQR
:..:: :::::::::::: :::: .:::.:::::::::::::.:::.::.:::: ::::
NP_067 DMIFYGFLKPWLGDGLLLSGGDKWSRHRRMLTPAFHFNILKPYMKIFNKSVNIMHDKWQR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 LAMEGSTCLDVFEHISLMTLDSLQKCIFSFDSNCQEKPSEYITAIMELSALVVKRNNQFF
:: :::. ::.:::::::::::::::.:::.:::::::::::.::.::::.: :::.:..
NP_067 LASEGSARLDMFEHISLMTLDSLQKCVFSFESNCQEKPSEYIAAILELSAFVEKRNQQIL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 RYKDFLYFLTPCGRRFHRACRLVHDFTDAVIQERRRTLTSQGVDDFLQAKAKSKTLDFID
. ::::.::: :.::.:::.:::::::::::::: :: .::.::::. :::::::::::
NP_067 LHTDFLYYLTPDGQRFRRACHLVHDFTDAVIQERRCTLPTQGIDDFLKNKAKSKTLDFID
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 VLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQE
:::::.:..:::::::::::::::::: ::::::::::::::.::.::::::.:::::::
NP_067 VLLLSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 LLKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVC
::::::: ::::::::::::::::.:::::::::.:...: :::: ::::.:::::: ::
NP_067 LLKDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVC
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE0 NINIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKV
:::..::.::.:::::::::::::: :: ..:::.::::::::::::::: ::::::::
NP_067 LINIIGIHYNPTVWPDPEVYDPFRFDQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKV
430 440 450 460 470 480
490 500 510 520
pF1KE0 VLALTLLRFRILPDHREPRRTPEIVLRAEDGLWLRVEPLG
:::::::.::::: : :::: ::..:::: ::::::::::
NP_067 VLALTLLHFRILPTHTEPRRKPELILRAEGGLWLRVEPLGANSQ
490 500 510 520
>>NP_076433 (OMIM: 611485) cytochrome P450 4F12 [Homo sa (524 aa)
initn: 2864 init1: 2864 opt: 2864 Z-score: 3587.9 bits: 673.5 E(85289): 4.2e-193
Smith-Waterman score: 2864; 78.2% identity (91.1% similar) in 519 aa overlap (1-519:1-519)
10 20 30 40 50 60
pF1KE0 MSLLSLSWLGLRPVAASPWLLLLVVGASWLLARILAWTYAFYHNGRRLRCFPQPRKQNWF
:::::: ::::::::.:::::::.: .:::::::::::::::.: :::.::::: :.:::
NP_076 MSLLSLPWLGLRPVATSPWLLLLLVVGSWLLARILAWTYAFYNNCRRLQCFPQPPKRNWF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 LGHLGLVTPTEEGLRVLTQLVATYPQGFVRWLGPITPIINLCHPDIVRSVINTSDAITDK
:::::.:::::::. ::. ::: :::. ::::: :.: ::::: .::. :.: ::. :
NP_076 WGHLGLITPTEEGLKNSTQMSATYSQGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 DIVFYKTLKPWLGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQR
: .: . ::::::.:.::: :::: .:::.::::::::::: :: ::.:::::: :::.
NP_076 DNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQH
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 LAMEGSTCLDVFEHISLMTLDSLQKCIFSFDSNCQEKPSEYITAIMELSALVVKRNNQFF
:: :::. ::.:::::::::::::::::::::.:::.:::::..:.:::::: ::.....
NP_076 LASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQHIL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 RYKDFLYFLTPCGRRFHRACRLVHDFTDAVIQERRRTLTSQGVDDFLQAKAKSKTLDFID
.. ::::.:. :::::::::::::::::::.:::::: .::.:::.. :::::::::::
NP_076 QHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFID
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 VLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQE
:::::.:..:: ::::::::::::::::::::::::::::::::::::::::::::::::
NP_076 VLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 LLKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVC
:::::.::::::::::::::::::.::::::::: : ..: ::::.::::.:::::: .:
NP_076 LLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITC
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE0 NINIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKV
:.:...::::.:::::::::::::::::.. :::.::::::::::::::: ::::::::
NP_076 LIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKV
430 440 450 460 470 480
490 500 510 520
pF1KE0 VLALTLLRFRILPDHREPRRTPEIVLRAEDGLWLRVEPLG
:::: ::.::.:::: :::: :...::: :::::::::
NP_076 VLALMLLHFRFLPDHTEPRRKLELIMRAEGGLWLRVEPLNVSLQ
490 500 510 520
>>XP_016881721 (OMIM: 611545) PREDICTED: cytochrome P450 (418 aa)
initn: 2857 init1: 2857 opt: 2857 Z-score: 3580.5 bits: 671.8 E(85289): 1.1e-192
Smith-Waterman score: 2857; 100.0% identity (100.0% similar) in 417 aa overlap (1-417:1-417)
10 20 30 40 50 60
pF1KE0 MSLLSLSWLGLRPVAASPWLLLLVVGASWLLARILAWTYAFYHNGRRLRCFPQPRKQNWF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSLLSLSWLGLRPVAASPWLLLLVVGASWLLARILAWTYAFYHNGRRLRCFPQPRKQNWF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 LGHLGLVTPTEEGLRVLTQLVATYPQGFVRWLGPITPIINLCHPDIVRSVINTSDAITDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGHLGLVTPTEEGLRVLTQLVATYPQGFVRWLGPITPIINLCHPDIVRSVINTSDAITDK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 DIVFYKTLKPWLGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DIVFYKTLKPWLGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 LAMEGSTCLDVFEHISLMTLDSLQKCIFSFDSNCQEKPSEYITAIMELSALVVKRNNQFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LAMEGSTCLDVFEHISLMTLDSLQKCIFSFDSNCQEKPSEYITAIMELSALVVKRNNQFF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 RYKDFLYFLTPCGRRFHRACRLVHDFTDAVIQERRRTLTSQGVDDFLQAKAKSKTLDFID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RYKDFLYFLTPCGRRFHRACRLVHDFTDAVIQERRRTLTSQGVDDFLQAKAKSKTLDFID
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 VLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 LLKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVC
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGL
370 380 390 400 410
430 440 450 460 470 480
pF1KE0 NINIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKV
>>NP_000887 (OMIM: 601270) docosahexaenoic acid omega-hy (520 aa)
initn: 2801 init1: 2801 opt: 2801 Z-score: 3508.9 bits: 658.9 E(85289): 1e-188
Smith-Waterman score: 2801; 77.3% identity (89.8% similar) in 519 aa overlap (1-519:1-519)
10 20 30 40 50 60
pF1KE0 MSLLSLSWLGLRPVAASPWLLLLVVGASWLLARILAWTYAFYHNGRRLRCFPQPRKQNWF
: :::: ::: :.:::::::::.:::::::::::::::.:: : :::::::: :.:::
NP_000 MPQLSLSSLGLWPMAASPWLLLLLVGASWLLARILAWTYTFYDNCCRLRCFPQPPKRNWF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 LGHLGLVTPTEEGLRVLTQLVATYPQGFVRWLGPITPIINLCHPDIVRSVINTSDAITDK
::::::. .:::: .:. :. . :.:: :. . :: .. :. . ::. :
NP_000 LGHLGLIHSSEEGLLYTQSLACTFGDMCCWWVGPWHAIVRIFHPTYIKPVLFAPAAIVPK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 DIVFYKTLKPWLGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQR
: :::. ::::::::::::.:.:: .:::.:::::::::::::.:::..:.::::::::
NP_000 DKVFYSFLKPWLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 LAMEGSTCLDVFEHISLMTLDSLQKCIFSFDSNCQEKPSEYITAIMELSALVVKRNNQFF
:: :::. ::.:::::::::::::::.:::::.:::::::::.::.::::::.::..:..
NP_000 LASEGSARLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVTKRHQQIL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 RYKDFLYFLTPCGRRFHRACRLVHDFTDAVIQERRRTLTSQGVDDFLQAKAKSKTLDFID
: ::::.::: :.::.::::::::::::::::::::: :::::::::::::::::::::
NP_000 LYIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFID
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 VLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQE
:::::.:..::.::::::::::::::: ::::::::::::::.::.::::::::::::::
NP_000 VLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 LLKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVC
::::::::::::::::::::::::.:::::::::.:. .: ::::.::::.:::::: .:
NP_000 LLKDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIIC
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE0 NINIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKV
:..:. ::::.:::::::::::::::.: ..:::.::::::::::::::: ::::::::
NP_000 LISVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKV
430 440 450 460 470 480
490 500 510 520
pF1KE0 VLALTLLRFRILPDHREPRRTPEIVLRAEDGLWLRVEPLG
::.:::::::.:::: :::: ::.::::: :::::::::
NP_000 VLGLTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS
490 500 510 520
520 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 13:54:12 2016 done: Thu Nov 3 13:54:14 2016
Total Scan time: 8.720 Total Display time: 0.100
Function used was FASTA [36.3.4 Apr, 2011]