FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0380, 581 aa 1>>>pF1KE0380 581 - 581 aa - 581 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.8418+/-0.000325; mu= 13.4287+/- 0.020 mean_var=115.6452+/-23.467, 0's: 0 Z-trim(119.7): 110 B-trim: 1011 in 1/52 Lambda= 0.119264 statistics sampled from 33866 (33977) to 33866 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.731), E-opt: 0.2 (0.398), width: 16 Scan time: 11.900 The best scores are: opt bits E(85289) NP_078918 (OMIM: 608812,610290) polypeptide N-acet ( 581) 4031 704.3 2.8e-202 XP_011517320 (OMIM: 608812,610290) PREDICTED: poly ( 507) 3198 560.9 3.5e-159 XP_016870622 (OMIM: 608812,610290) PREDICTED: poly ( 497) 3191 559.7 7.9e-159 XP_011517322 (OMIM: 608812,610290) PREDICTED: poly ( 345) 2400 423.5 5.5e-118 NP_003765 (OMIM: 603565) polypeptide N-acetylgalac ( 578) 2164 383.1 1.4e-105 XP_006717350 (OMIM: 608812,610290) PREDICTED: poly ( 284) 2011 356.5 6.6e-98 XP_016858750 (OMIM: 608369) PREDICTED: polypeptide ( 556) 1482 265.7 2.8e-70 NP_443149 (OMIM: 608369) polypeptide N-acetylgalac ( 556) 1482 265.7 2.8e-70 XP_011508839 (OMIM: 608369) PREDICTED: polypeptide ( 571) 1456 261.2 6.5e-69 XP_016858748 (OMIM: 608369) PREDICTED: polypeptide ( 571) 1456 261.2 6.5e-69 XP_016858747 (OMIM: 608369) PREDICTED: polypeptide ( 571) 1456 261.2 6.5e-69 XP_005258296 (OMIM: 602273) PREDICTED: polypeptide ( 559) 1446 259.5 2.1e-68 NP_065207 (OMIM: 602273) polypeptide N-acetylgalac ( 559) 1446 259.5 2.1e-68 XP_016881181 (OMIM: 602273) PREDICTED: polypeptide ( 559) 1446 259.5 2.1e-68 XP_016858749 (OMIM: 608369) PREDICTED: polypeptide ( 561) 1397 251.1 7.3e-66 NP_001288556 (OMIM: 608369) polypeptide N-acetylga ( 561) 1397 251.1 7.3e-66 NP_473451 (OMIM: 615131) polypeptide N-acetylgalac ( 639) 1369 246.3 2.3e-64 NP_004472 (OMIM: 602274) polypeptide N-acetylgalac ( 571) 1340 241.3 6.6e-63 NP_001278795 (OMIM: 602274) polypeptide N-acetylga ( 533) 1326 238.9 3.3e-62 XP_005246506 (OMIM: 601756) PREDICTED: polypeptide ( 633) 1325 238.7 4.3e-62 XP_016859259 (OMIM: 601756) PREDICTED: polypeptide ( 633) 1325 238.7 4.3e-62 XP_011509231 (OMIM: 601756) PREDICTED: polypeptide ( 633) 1325 238.7 4.3e-62 NP_004473 (OMIM: 601756) polypeptide N-acetylgalac ( 633) 1325 238.7 4.3e-62 XP_006719277 (OMIM: 605148) PREDICTED: polypeptide ( 622) 1322 238.2 6e-62 XP_011536124 (OMIM: 605148) PREDICTED: polypeptide ( 622) 1322 238.2 6e-62 NP_009141 (OMIM: 605148) polypeptide N-acetylgalac ( 622) 1322 238.2 6e-62 XP_011536121 (OMIM: 605148) PREDICTED: polypeptide ( 622) 1322 238.2 6e-62 XP_016874233 (OMIM: 605148) PREDICTED: polypeptide ( 622) 1322 238.2 6e-62 XP_005268664 (OMIM: 605148) PREDICTED: polypeptide ( 622) 1322 238.2 6e-62 XP_016874234 (OMIM: 605148) PREDICTED: polypeptide ( 622) 1322 238.2 6e-62 XP_016856452 (OMIM: 602274) PREDICTED: polypeptide ( 636) 1296 233.7 1.4e-60 NP_001305980 (OMIM: 615131) polypeptide N-acetylga ( 617) 1291 232.9 2.4e-60 NP_938080 (OMIM: 608043) polypeptide N-acetylgalac ( 603) 1288 232.3 3.4e-60 XP_005264909 (OMIM: 615131) PREDICTED: polypeptide ( 593) 1283 231.5 6.1e-60 XP_016856455 (OMIM: 602274) PREDICTED: polypeptide ( 569) 1282 231.3 6.6e-60 XP_016856454 (OMIM: 602274) PREDICTED: polypeptide ( 598) 1282 231.3 6.9e-60 XP_016856453 (OMIM: 602274) PREDICTED: polypeptide ( 605) 1282 231.3 7e-60 NP_001030017 (OMIM: 615138) polypeptide N-acetylga ( 601) 1239 223.9 1.2e-57 XP_011530295 (OMIM: 615138) PREDICTED: polypeptide ( 522) 1238 223.7 1.2e-57 XP_016863733 (OMIM: 615138) PREDICTED: polypeptide ( 609) 1239 223.9 1.2e-57 NP_001291443 (OMIM: 615130) polypeptide N-acetylga ( 527) 1193 216.0 2.5e-55 XP_016876987 (OMIM: 615132) PREDICTED: polypeptide ( 558) 1186 214.8 6.1e-55 NP_001161840 (OMIM: 615132) polypeptide N-acetylga ( 558) 1186 214.8 6.1e-55 NP_065743 (OMIM: 615132) polypeptide N-acetylgalac ( 558) 1186 214.8 6.1e-55 XP_011535307 (OMIM: 615132) PREDICTED: polypeptide ( 558) 1186 214.8 6.1e-55 XP_011535308 (OMIM: 615132) PREDICTED: polypeptide ( 558) 1186 214.8 6.1e-55 XP_006716145 (OMIM: 615130) PREDICTED: polypeptide ( 608) 1179 213.6 1.5e-54 NP_071370 (OMIM: 615130) polypeptide N-acetylgalac ( 608) 1179 213.6 1.5e-54 XP_006716147 (OMIM: 615130) PREDICTED: polypeptide ( 608) 1179 213.6 1.5e-54 XP_006716146 (OMIM: 615130) PREDICTED: polypeptide ( 608) 1179 213.6 1.5e-54 >>NP_078918 (OMIM: 608812,610290) polypeptide N-acetylga (581 aa) initn: 4031 init1: 4031 opt: 4031 Z-score: 3752.6 bits: 704.3 E(85289): 2.8e-202 Smith-Waterman score: 4031; 100.0% identity (100.0% similar) in 581 aa overlap (1-581:1-581) 10 20 30 40 50 60 pF1KE0 MWGRTARRRCPRELRRGREALLVLLALLALAGLGSVLRAQRGAGAGAAEPGPPRTPRPGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_078 MWGRTARRRCPRELRRGREALLVLLALLALAGLGSVLRAQRGAGAGAAEPGPPRTPRPGR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 REPVMPRPPVPANALGARGEAVRLQLQGEELRLQEESVRLHQINIYLSDRISLHRRLPER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_078 REPVMPRPPVPANALGARGEAVRLQLQGEELRLQEESVRLHQINIYLSDRISLHRRLPER 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 WNPLCKEKKYDYDNLPRTSVIIAFYNEAWSTLLRTVYSVLETSPDILLEEVILVDDYSDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_078 WNPLCKEKKYDYDNLPRTSVIIAFYNEAWSTLLRTVYSVLETSPDILLEEVILVDDYSDR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 EHLKERLANELSGLPKVRLIRANKREGLVRARLLGASAARGDVLTFLDCHCECHEGWLEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_078 EHLKERLANELSGLPKVRLIRANKREGLVRARLLGASAARGDVLTFLDCHCECHEGWLEP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 LLQRIHEEESAVVCPVIDVIDWNTFEYLGNSGEPQIGGFDWRLVFTWHTVPERERIRMQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_078 LLQRIHEEESAVVCPVIDVIDWNTFEYLGNSGEPQIGGFDWRLVFTWHTVPERERIRMQS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 PVDVIRSPTMAGGLFAVSKKYFEYLGSYDTGMEVWGGENLEFSFRIWQCGGVLETHPCSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_078 PVDVIRSPTMAGGLFAVSKKYFEYLGSYDTGMEVWGGENLEFSFRIWQCGGVLETHPCSH 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 VGHVFPKQAPYSRNKALANSVRAAEVWMDEFKELYYHRNPRARLEPFGDVTERKQLRDKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_078 VGHVFPKQAPYSRNKALANSVRAAEVWMDEFKELYYHRNPRARLEPFGDVTERKQLRDKL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE0 QCKDFKWFLETVYPELHVPEDRPGFFGMLQNKGLTDYCFDYNPPDENQIVGHQVILYLCH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_078 QCKDFKWFLETVYPELHVPEDRPGFFGMLQNKGLTDYCFDYNPPDENQIVGHQVILYLCH 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE0 GMGQNQFFEYTSQKEIRYNTHQPEGCIAVEAGMDTLIMHLCEETAPENQKFILQEDGSLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_078 GMGQNQFFEYTSQKEIRYNTHQPEGCIAVEAGMDTLIMHLCEETAPENQKFILQEDGSLF 490 500 510 520 530 540 550 560 570 580 pF1KE0 HEQSKKCVQAARKESSDSFVPLLRDCTNSDHQKWFFKERML ::::::::::::::::::::::::::::::::::::::::: NP_078 HEQSKKCVQAARKESSDSFVPLLRDCTNSDHQKWFFKERML 550 560 570 580 >>XP_011517320 (OMIM: 608812,610290) PREDICTED: polypept (507 aa) initn: 3190 init1: 3190 opt: 3198 Z-score: 2978.9 bits: 560.9 E(85289): 3.5e-159 Smith-Waterman score: 3198; 93.9% identity (97.0% similar) in 492 aa overlap (91-581:16-507) 70 80 90 100 110 pF1KE0 REPVMPRPPVPANALGARGEAVRLQLQGEELRLQEESVRLHQINI-YLSDRISLHRRLPE : :....:..: . .. . . . . : XP_011 MPPASNSCSKACWVILTQPERKIHLENIRVAFFLESVLQYFKSTE 10 20 30 40 120 130 140 150 160 170 pF1KE0 RWNPLCKEKKYDYDNLPRTSVIIAFYNEAWSTLLRTVYSVLETSPDILLEEVILVDDYSD . . ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HVQFRCKEKKYDYDNLPRTSVIIAFYNEAWSTLLRTVYSVLETSPDILLEEVILVDDYSD 50 60 70 80 90 100 180 190 200 210 220 230 pF1KE0 REHLKERLANELSGLPKVRLIRANKREGLVRARLLGASAARGDVLTFLDCHCECHEGWLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 REHLKERLANELSGLPKVRLIRANKREGLVRARLLGASAARGDVLTFLDCHCECHEGWLE 110 120 130 140 150 160 240 250 260 270 280 290 pF1KE0 PLLQRIHEEESAVVCPVIDVIDWNTFEYLGNSGEPQIGGFDWRLVFTWHTVPERERIRMQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PLLQRIHEEESAVVCPVIDVIDWNTFEYLGNSGEPQIGGFDWRLVFTWHTVPERERIRMQ 170 180 190 200 210 220 300 310 320 330 340 350 pF1KE0 SPVDVIRSPTMAGGLFAVSKKYFEYLGSYDTGMEVWGGENLEFSFRIWQCGGVLETHPCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SPVDVIRSPTMAGGLFAVSKKYFEYLGSYDTGMEVWGGENLEFSFRIWQCGGVLETHPCS 230 240 250 260 270 280 360 370 380 390 400 410 pF1KE0 HVGHVFPKQAPYSRNKALANSVRAAEVWMDEFKELYYHRNPRARLEPFGDVTERKQLRDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HVGHVFPKQAPYSRNKALANSVRAAEVWMDEFKELYYHRNPRARLEPFGDVTERKQLRDK 290 300 310 320 330 340 420 430 440 450 460 470 pF1KE0 LQCKDFKWFLETVYPELHVPEDRPGFFGMLQNKGLTDYCFDYNPPDENQIVGHQVILYLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LQCKDFKWFLETVYPELHVPEDRPGFFGMLQNKGLTDYCFDYNPPDENQIVGHQVILYLC 350 360 370 380 390 400 480 490 500 510 520 530 pF1KE0 HGMGQNQFFEYTSQKEIRYNTHQPEGCIAVEAGMDTLIMHLCEETAPENQKFILQEDGSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HGMGQNQFFEYTSQKEIRYNTHQPEGCIAVEAGMDTLIMHLCEETAPENQKFILQEDGSL 410 420 430 440 450 460 540 550 560 570 580 pF1KE0 FHEQSKKCVQAARKESSDSFVPLLRDCTNSDHQKWFFKERML :::::::::::::::::::::::::::::::::::::::::: XP_011 FHEQSKKCVQAARKESSDSFVPLLRDCTNSDHQKWFFKERML 470 480 490 500 >>XP_016870622 (OMIM: 608812,610290) PREDICTED: polypept (497 aa) initn: 3190 init1: 3190 opt: 3191 Z-score: 2972.5 bits: 559.7 E(85289): 7.9e-159 Smith-Waterman score: 3191; 94.8% identity (97.5% similar) in 485 aa overlap (98-581:13-497) 70 80 90 100 110 120 pF1KE0 PPVPANALGARGEAVRLQLQGEELRLQEESVRLHQINI-YLSDRISLHRRLPERWNPLCK ..:..: . .. . . . . :. . :: XP_016 MMTRNPSLHGNIIHLENIRVAFFLESVLQYFKSTEHVQFRCK 10 20 30 40 130 140 150 160 170 180 pF1KE0 EKKYDYDNLPRTSVIIAFYNEAWSTLLRTVYSVLETSPDILLEEVILVDDYSDREHLKER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EKKYDYDNLPRTSVIIAFYNEAWSTLLRTVYSVLETSPDILLEEVILVDDYSDREHLKER 50 60 70 80 90 100 190 200 210 220 230 240 pF1KE0 LANELSGLPKVRLIRANKREGLVRARLLGASAARGDVLTFLDCHCECHEGWLEPLLQRIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LANELSGLPKVRLIRANKREGLVRARLLGASAARGDVLTFLDCHCECHEGWLEPLLQRIH 110 120 130 140 150 160 250 260 270 280 290 300 pF1KE0 EEESAVVCPVIDVIDWNTFEYLGNSGEPQIGGFDWRLVFTWHTVPERERIRMQSPVDVIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EEESAVVCPVIDVIDWNTFEYLGNSGEPQIGGFDWRLVFTWHTVPERERIRMQSPVDVIR 170 180 190 200 210 220 310 320 330 340 350 360 pF1KE0 SPTMAGGLFAVSKKYFEYLGSYDTGMEVWGGENLEFSFRIWQCGGVLETHPCSHVGHVFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SPTMAGGLFAVSKKYFEYLGSYDTGMEVWGGENLEFSFRIWQCGGVLETHPCSHVGHVFP 230 240 250 260 270 280 370 380 390 400 410 420 pF1KE0 KQAPYSRNKALANSVRAAEVWMDEFKELYYHRNPRARLEPFGDVTERKQLRDKLQCKDFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KQAPYSRNKALANSVRAAEVWMDEFKELYYHRNPRARLEPFGDVTERKQLRDKLQCKDFK 290 300 310 320 330 340 430 440 450 460 470 480 pF1KE0 WFLETVYPELHVPEDRPGFFGMLQNKGLTDYCFDYNPPDENQIVGHQVILYLCHGMGQNQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WFLETVYPELHVPEDRPGFFGMLQNKGLTDYCFDYNPPDENQIVGHQVILYLCHGMGQNQ 350 360 370 380 390 400 490 500 510 520 530 540 pF1KE0 FFEYTSQKEIRYNTHQPEGCIAVEAGMDTLIMHLCEETAPENQKFILQEDGSLFHEQSKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FFEYTSQKEIRYNTHQPEGCIAVEAGMDTLIMHLCEETAPENQKFILQEDGSLFHEQSKK 410 420 430 440 450 460 550 560 570 580 pF1KE0 CVQAARKESSDSFVPLLRDCTNSDHQKWFFKERML ::::::::::::::::::::::::::::::::::: XP_016 CVQAARKESSDSFVPLLRDCTNSDHQKWFFKERML 470 480 490 >>XP_011517322 (OMIM: 608812,610290) PREDICTED: polypept (345 aa) initn: 2400 init1: 2400 opt: 2400 Z-score: 2239.3 bits: 423.5 E(85289): 5.5e-118 Smith-Waterman score: 2400; 100.0% identity (100.0% similar) in 338 aa overlap (244-581:8-345) 220 230 240 250 260 270 pF1KE0 LGASAARGDVLTFLDCHCECHEGWLEPLLQRIHEEESAVVCPVIDVIDWNTFEYLGNSGE :::::::::::::::::::::::::::::: XP_011 MDVLGAFRIHEEESAVVCPVIDVIDWNTFEYLGNSGE 10 20 30 280 290 300 310 320 330 pF1KE0 PQIGGFDWRLVFTWHTVPERERIRMQSPVDVIRSPTMAGGLFAVSKKYFEYLGSYDTGME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PQIGGFDWRLVFTWHTVPERERIRMQSPVDVIRSPTMAGGLFAVSKKYFEYLGSYDTGME 40 50 60 70 80 90 340 350 360 370 380 390 pF1KE0 VWGGENLEFSFRIWQCGGVLETHPCSHVGHVFPKQAPYSRNKALANSVRAAEVWMDEFKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VWGGENLEFSFRIWQCGGVLETHPCSHVGHVFPKQAPYSRNKALANSVRAAEVWMDEFKE 100 110 120 130 140 150 400 410 420 430 440 450 pF1KE0 LYYHRNPRARLEPFGDVTERKQLRDKLQCKDFKWFLETVYPELHVPEDRPGFFGMLQNKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LYYHRNPRARLEPFGDVTERKQLRDKLQCKDFKWFLETVYPELHVPEDRPGFFGMLQNKG 160 170 180 190 200 210 460 470 480 490 500 510 pF1KE0 LTDYCFDYNPPDENQIVGHQVILYLCHGMGQNQFFEYTSQKEIRYNTHQPEGCIAVEAGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LTDYCFDYNPPDENQIVGHQVILYLCHGMGQNQFFEYTSQKEIRYNTHQPEGCIAVEAGM 220 230 240 250 260 270 520 530 540 550 560 570 pF1KE0 DTLIMHLCEETAPENQKFILQEDGSLFHEQSKKCVQAARKESSDSFVPLLRDCTNSDHQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DTLIMHLCEETAPENQKFILQEDGSLFHEQSKKCVQAARKESSDSFVPLLRDCTNSDHQK 280 290 300 310 320 330 580 pF1KE0 WFFKERML :::::::: XP_011 WFFKERML 340 >>NP_003765 (OMIM: 603565) polypeptide N-acetylgalactosa (578 aa) initn: 2076 init1: 1927 opt: 2164 Z-score: 2016.5 bits: 383.1 E(85289): 1.4e-105 Smith-Waterman score: 2166; 57.0% identity (77.9% similar) in 570 aa overlap (23-578:13-578) 10 20 30 40 50 pF1KE0 MWGRTARRRCPRELRRGREALLVLLALLALAG-----LGSVLRAQRGAGAGAAEPGPPRT .:::.:..: : :...:. ::: : : : : NP_003 MAVRWTWAGKSCLLLAFLTVAYIFVELLVSTFHASAGAGR-ARELGSRRL 10 20 30 40 60 70 80 90 100 110 pF1KE0 PRPGRR-----EPVMPRPPVPANALGARGEAVRLQLQGEELRLQEESVRLHQINIYLSDR . .:.. .::. . ::: :.: .:::. .::. ::: .. . :::::::: NP_003 SDLQKNTEDLSRPLYKKPPADSRALGEWGKASKLQLNEDELKQQEELIERYAINIYLSDR 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE0 ISLHRRLPERWNPLCKEKKYDYDNLPRTSVIIAFYNEAWSTLLRTVYSVLETSPDILLEE :::::.. .. :: .:..: .:: ::::::::::::::::::..::::::: .::.: NP_003 ISLHRHIEDKRMYECKSQKFNYRTLPTTSVIIAFYNEAWSTLLRTIHSVLETSPAVLLKE 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE0 VILVDDYSDREHLKERLANELSGLPKVRLIRANKREGLVRARLLGASAARGDVLTFLDCH .::::: ::: .:: .: . .:.: .:::::.:::::::::::.::. : :::::::::: NP_003 IILVDDLSDRVYLKTQLETYISNLDRVRLIRTNKREGLVRARLIGATFATGDVLTFLDCH 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE0 CECHEGWLEPLLQRIHEEESAVVCPVIDVIDWNTFEYLGNSGEPQIGGFDWRLVFTWHTV :::. :::::::.:: ..:.::::::::.:::::::. . :::.::::::::.: ::.: NP_003 CECNSGWLEPLLERIGRDETAVVCPVIDTIDWNTFEFYMQIGEPMIGGFDWRLTFQWHSV 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE0 PERERIRMQSPVDVIRSPTMAGGLFAVSKKYFEYLGSYDTGMEVWGGENLEFSFRIWQCG :..:: : : .: ::::::::::::::::::.:::.::::::::::::::.:::.:::: NP_003 PKQERDRRISRIDPIRSPTMAGGLFAVSKKYFQYLGTYDTGMEVWGGENLELSFRVWQCG 290 300 310 320 330 340 360 370 380 390 400 410 pF1KE0 GVLETHPCSHVGHVFPKQAPYSRNKALANSVRAAEVWMDEFKELYYHRNPRARLEPFGDV : :: ::::::::::::.:::.: . : :..:::::::::.:: .:.::: :: : .::. NP_003 GKLEIHPCSHVGHVFPKRAPYARPNFLQNTARAAEVWMDEYKEHFYNRNPPARKEAYGDI 350 360 370 380 390 400 420 430 440 450 460 470 pF1KE0 TERKQLRDKLQCKDFKWFLETVYPELHVPEDRPGFFGMLQNKGLTDYCFDYNPPDENQIV .::: ::..:.::.: :.:..:.:.:::::::::. : ....:... :.::: ::.: . NP_003 SERKLLRERLRCKSFDWYLKNVFPNLHVPEDRPGWHGAIRSRGISSECLDYNSPDNNP-T 410 420 430 440 450 460 480 490 500 510 520 pF1KE0 GHQVILYLCHGMGQNQFFEYTSQKEIRYNTHQPEGCIAVEAGMDTLIMHLCEETA---PE : .. :. :::.: ::::::::.::::.:. : : : . . :. : . . : NP_003 GANLSLFGCHGQGGNQFFEYTSNKEIRFNS-VTELCAEVPEQKNYVGMQNCPKDGFPVPA 470 480 490 500 510 520 530 540 550 560 570 580 pF1KE0 NQKFILQEDGSLFHEQSKKCVQAARKESSDSFVPLLRDCTNSD-HQKWFFKERML : . ..:::..:: .: :..: : . : . : : : .: : :.. NP_003 NIIWHFKEDGTIFHPHSGLCLSAYRTPEGRPDVQM-RTCDALDKNQIWSFEK 530 540 550 560 570 >>XP_006717350 (OMIM: 608812,610290) PREDICTED: polypept (284 aa) initn: 2011 init1: 2011 opt: 2011 Z-score: 1878.8 bits: 356.5 E(85289): 6.6e-98 Smith-Waterman score: 2011; 100.0% identity (100.0% similar) in 284 aa overlap (298-581:1-284) 270 280 290 300 310 320 pF1KE0 LGNSGEPQIGGFDWRLVFTWHTVPERERIRMQSPVDVIRSPTMAGGLFAVSKKYFEYLGS :::::::::::::::::::::::::::::: XP_006 MQSPVDVIRSPTMAGGLFAVSKKYFEYLGS 10 20 30 330 340 350 360 370 380 pF1KE0 YDTGMEVWGGENLEFSFRIWQCGGVLETHPCSHVGHVFPKQAPYSRNKALANSVRAAEVW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YDTGMEVWGGENLEFSFRIWQCGGVLETHPCSHVGHVFPKQAPYSRNKALANSVRAAEVW 40 50 60 70 80 90 390 400 410 420 430 440 pF1KE0 MDEFKELYYHRNPRARLEPFGDVTERKQLRDKLQCKDFKWFLETVYPELHVPEDRPGFFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MDEFKELYYHRNPRARLEPFGDVTERKQLRDKLQCKDFKWFLETVYPELHVPEDRPGFFG 100 110 120 130 140 150 450 460 470 480 490 500 pF1KE0 MLQNKGLTDYCFDYNPPDENQIVGHQVILYLCHGMGQNQFFEYTSQKEIRYNTHQPEGCI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MLQNKGLTDYCFDYNPPDENQIVGHQVILYLCHGMGQNQFFEYTSQKEIRYNTHQPEGCI 160 170 180 190 200 210 510 520 530 540 550 560 pF1KE0 AVEAGMDTLIMHLCEETAPENQKFILQEDGSLFHEQSKKCVQAARKESSDSFVPLLRDCT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 AVEAGMDTLIMHLCEETAPENQKFILQEDGSLFHEQSKKCVQAARKESSDSFVPLLRDCT 220 230 240 250 260 270 570 580 pF1KE0 NSDHQKWFFKERML :::::::::::::: XP_006 NSDHQKWFFKERML 280 >>XP_016858750 (OMIM: 608369) PREDICTED: polypeptide N-a (556 aa) initn: 1218 init1: 657 opt: 1482 Z-score: 1382.6 bits: 265.7 E(85289): 2.8e-70 Smith-Waterman score: 1482; 46.2% identity (71.2% similar) in 513 aa overlap (76-581:58-554) 50 60 70 80 90 100 pF1KE0 GAAEPGPPRTPRPGRREPVMPRPPVPANALGARGEAVRLQLQGEELRLQEESVRLHQINI : :.:: . . .: ...: ...:.:. XP_016 FSECNKCDDKKERSLLPALRAVISRNQEGPGEMGKAVLIPKDDQE-KMKEL-FKINQFNL 30 40 50 60 70 80 110 120 130 140 150 160 pF1KE0 YLSDRISLHRRLPERWNPLCKEKKYDYDNLPRTSVIIAFYNEAWSTLLRTVYSVLETSPD . :: :.:.: ::. :: : : :.:: :::.:.:.::::::::::::::.. :: XP_016 MASDLIALNRSLPDVRLEGCKTKVYP-DELPNTSVVIVFHNEAWSTLLRTVYSVINRSPH 90 100 110 120 130 140 170 180 190 200 210 220 pF1KE0 ILLEEVILVDDYSDREHLKERLANELSGLP-KVRLIRANKREGLVRARLLGASAARGDVL :: ::::::: :.:. :: : : ...: :..:: ..: ::.:::: ::.:..:.:. XP_016 YLLSEVILVDDASERDFLKLTLENYVKNLEVPVKIIRMEERSGLIRARLRGAAASKGQVI 150 160 170 180 190 200 230 240 250 260 270 280 pF1KE0 TFLDCHCECHEGWLEPLLQRIHEEESAVVCPVIDVIDWNTFEYLGNSGEPQIGGFDWRLV :::: :::: ::::::: ::.:....::::.::::. .::::...: . :::.:.: XP_016 TFLDAHCECTLGWLEPLLARIKEDRKTVVCPIIDVISDDTFEYMAGS-DMTYGGFNWKLN 210 220 230 240 250 260 290 300 310 320 330 340 pF1KE0 FTWHTVPERERIRMQSPVDV-IRSPTMAGGLFAVSKKYFEYLGSYDTGMEVWGGENLEFS : :. ::.:: : .. . .:.::::::::.....::: .:.::.::..:::::::.: XP_016 FRWYPVPQREMDRRKGDRTLPVRTPTMAGGLFSIDRNYFEEIGTYDAGMDIWGGENLEMS 270 280 290 300 310 320 350 360 370 380 390 pF1KE0 FRIWQCGGVLETHPCSHVGHVFPKQAPYSRNKALA-----NSVRAAEVWMDEFKELYYHR :::::::: :: :::::::: : .::. . . :. : :::::::::...: XP_016 FRIWQCGGSLEIVTCSHVGHVFRKATPYTFPGGTGHVINKNNRRLAEVWMDEFKDFFYII 330 340 350 360 370 380 400 410 420 430 440 450 pF1KE0 NPRARLEPFGDVTERKQLRDKLQCKDFKWFLETVYPELHVPEDRPGFFGMLQNKGLTDYC .: . .:::. :: ::..:.:: :.:.::..::. ..:. : .: ..: :. : XP_016 SPGVVKVDYGDVSVRKTLRENLKCKPFSWYLENIYPDSQIPR-RYYSLGEIRNVE-TNQC 390 400 410 420 430 440 460 470 480 490 500 510 pF1KE0 FDYNPPDENQIVGHQVILYLCHGMGQNQFFEYTSQKEIRYNTHQPEGCIAVEAGMDTLIM .: ::. :: .. ::::: :: : ::..:::: . . :. : .:: XP_016 LDNMGRKENEKVG----IFNCHGMGGNQVFSYTADKEIRTD----DLCLDVSRLNGPVIM 450 460 470 480 490 520 530 540 550 560 570 pF1KE0 HLCEETAPENQKFILQEDGSLFHEQSKKCVQAARKESSDSFVPLLRDCTNSDHQKWFFKE :.. .. : .: : .:..:.. .: :..:: ..::..: :.:.... XP_016 LKCHHMRGNQLWEYDAERLTLRHVNSNQCLDEPSEE--DKMVPTMQDCSGSRSQQWLLRN 500 510 520 530 540 550 580 pF1KE0 RML : XP_016 MTLGT >>NP_443149 (OMIM: 608369) polypeptide N-acetylgalactosa (556 aa) initn: 1218 init1: 657 opt: 1482 Z-score: 1382.6 bits: 265.7 E(85289): 2.8e-70 Smith-Waterman score: 1482; 46.2% identity (71.2% similar) in 513 aa overlap (76-581:58-554) 50 60 70 80 90 100 pF1KE0 GAAEPGPPRTPRPGRREPVMPRPPVPANALGARGEAVRLQLQGEELRLQEESVRLHQINI : :.:: . . .: ...: ...:.:. NP_443 FSECNKCDDKKERSLLPALRAVISRNQEGPGEMGKAVLIPKDDQE-KMKEL-FKINQFNL 30 40 50 60 70 80 110 120 130 140 150 160 pF1KE0 YLSDRISLHRRLPERWNPLCKEKKYDYDNLPRTSVIIAFYNEAWSTLLRTVYSVLETSPD . :: :.:.: ::. :: : : :.:: :::.:.:.::::::::::::::.. :: NP_443 MASDLIALNRSLPDVRLEGCKTKVYP-DELPNTSVVIVFHNEAWSTLLRTVYSVINRSPH 90 100 110 120 130 140 170 180 190 200 210 220 pF1KE0 ILLEEVILVDDYSDREHLKERLANELSGLP-KVRLIRANKREGLVRARLLGASAARGDVL :: ::::::: :.:. :: : : ...: :..:: ..: ::.:::: ::.:..:.:. NP_443 YLLSEVILVDDASERDFLKLTLENYVKNLEVPVKIIRMEERSGLIRARLRGAAASKGQVI 150 160 170 180 190 200 230 240 250 260 270 280 pF1KE0 TFLDCHCECHEGWLEPLLQRIHEEESAVVCPVIDVIDWNTFEYLGNSGEPQIGGFDWRLV :::: :::: ::::::: ::.:....::::.::::. .::::...: . :::.:.: NP_443 TFLDAHCECTLGWLEPLLARIKEDRKTVVCPIIDVISDDTFEYMAGS-DMTYGGFNWKLN 210 220 230 240 250 260 290 300 310 320 330 340 pF1KE0 FTWHTVPERERIRMQSPVDV-IRSPTMAGGLFAVSKKYFEYLGSYDTGMEVWGGENLEFS : :. ::.:: : .. . .:.::::::::.....::: .:.::.::..:::::::.: NP_443 FRWYPVPQREMDRRKGDRTLPVRTPTMAGGLFSIDRNYFEEIGTYDAGMDIWGGENLEMS 270 280 290 300 310 320 350 360 370 380 390 pF1KE0 FRIWQCGGVLETHPCSHVGHVFPKQAPYSRNKALA-----NSVRAAEVWMDEFKELYYHR :::::::: :: :::::::: : .::. . . :. : :::::::::...: NP_443 FRIWQCGGSLEIVTCSHVGHVFRKATPYTFPGGTGHVINKNNRRLAEVWMDEFKDFFYII 330 340 350 360 370 380 400 410 420 430 440 450 pF1KE0 NPRARLEPFGDVTERKQLRDKLQCKDFKWFLETVYPELHVPEDRPGFFGMLQNKGLTDYC .: . .:::. :: ::..:.:: :.:.::..::. ..:. : .: ..: :. : NP_443 SPGVVKVDYGDVSVRKTLRENLKCKPFSWYLENIYPDSQIPR-RYYSLGEIRNVE-TNQC 390 400 410 420 430 440 460 470 480 490 500 510 pF1KE0 FDYNPPDENQIVGHQVILYLCHGMGQNQFFEYTSQKEIRYNTHQPEGCIAVEAGMDTLIM .: ::. :: .. ::::: :: : ::..:::: . . :. : .:: NP_443 LDNMGRKENEKVG----IFNCHGMGGNQVFSYTADKEIRTD----DLCLDVSRLNGPVIM 450 460 470 480 490 520 530 540 550 560 570 pF1KE0 HLCEETAPENQKFILQEDGSLFHEQSKKCVQAARKESSDSFVPLLRDCTNSDHQKWFFKE :.. .. : .: : .:..:.. .: :..:: ..::..: :.:.... NP_443 LKCHHMRGNQLWEYDAERLTLRHVNSNQCLDEPSEE--DKMVPTMQDCSGSRSQQWLLRN 500 510 520 530 540 550 580 pF1KE0 RML : NP_443 MTLGT >>XP_011508839 (OMIM: 608369) PREDICTED: polypeptide N-a (571 aa) initn: 1165 init1: 657 opt: 1456 Z-score: 1358.2 bits: 261.2 E(85289): 6.5e-69 Smith-Waterman score: 1456; 46.0% identity (70.9% similar) in 509 aa overlap (76-577:58-551) 50 60 70 80 90 100 pF1KE0 GAAEPGPPRTPRPGRREPVMPRPPVPANALGARGEAVRLQLQGEELRLQEESVRLHQINI : :.:: . . .: ...: ...:.:. XP_011 FSECNKCDDKKERSLLPALRAVISRNQEGPGEMGKAVLIPKDDQE-KMKEL-FKINQFNL 30 40 50 60 70 80 110 120 130 140 150 160 pF1KE0 YLSDRISLHRRLPERWNPLCKEKKYDYDNLPRTSVIIAFYNEAWSTLLRTVYSVLETSPD . :: :.:.: ::. :: : : :.:: :::.:.:.::::::::::::::.. :: XP_011 MASDLIALNRSLPDVRLEGCKTKVYP-DELPNTSVVIVFHNEAWSTLLRTVYSVINRSPH 90 100 110 120 130 140 170 180 190 200 210 220 pF1KE0 ILLEEVILVDDYSDREHLKERLANELSGLP-KVRLIRANKREGLVRARLLGASAARGDVL :: ::::::: :.:. :: : : ...: :..:: ..: ::.:::: ::.:..:.:. XP_011 YLLSEVILVDDASERDFLKLTLENYVKNLEVPVKIIRMEERSGLIRARLRGAAASKGQVI 150 160 170 180 190 200 230 240 250 260 270 280 pF1KE0 TFLDCHCECHEGWLEPLLQRIHEEESAVVCPVIDVIDWNTFEYLGNSGEPQIGGFDWRLV :::: :::: ::::::: ::.:....::::.::::. .::::...: . :::.:.: XP_011 TFLDAHCECTLGWLEPLLARIKEDRKTVVCPIIDVISDDTFEYMAGS-DMTYGGFNWKLN 210 220 230 240 250 260 290 300 310 320 330 340 pF1KE0 FTWHTVPERERIRMQSPVDV-IRSPTMAGGLFAVSKKYFEYLGSYDTGMEVWGGENLEFS : :. ::.:: : .. . .:.::::::::.....::: .:.::.::..:::::::.: XP_011 FRWYPVPQREMDRRKGDRTLPVRTPTMAGGLFSIDRNYFEEIGTYDAGMDIWGGENLEMS 270 280 290 300 310 320 350 360 370 380 390 pF1KE0 FRIWQCGGVLETHPCSHVGHVFPKQAPYSRNKALA-----NSVRAAEVWMDEFKELYYHR :::::::: :: :::::::: : .::. . . :. : :::::::::...: XP_011 FRIWQCGGSLEIVTCSHVGHVFRKATPYTFPGGTGHVINKNNRRLAEVWMDEFKDFFYII 330 340 350 360 370 380 400 410 420 430 440 450 pF1KE0 NPRARLEPFGDVTERKQLRDKLQCKDFKWFLETVYPELHVPEDRPGFFGMLQNKGLTDYC .: . .:::. :: ::..:.:: :.:.::..::. ..:. : .: ..: :. : XP_011 SPGVVKVDYGDVSVRKTLRENLKCKPFSWYLENIYPDSQIPR-RYYSLGEIRNVE-TNQC 390 400 410 420 430 440 460 470 480 490 500 510 pF1KE0 FDYNPPDENQIVGHQVILYLCHGMGQNQFFEYTSQKEIRYNTHQPEGCIAVEAGMDTLIM .: ::. :: .. ::::: :: : ::..:::: . . :. : .:: XP_011 LDNMGRKENEKVG----IFNCHGMGGNQVFSYTADKEIRTD----DLCLDVSRLNGPVIM 450 460 470 480 490 520 530 540 550 560 570 pF1KE0 HLCEETAPENQKFILQEDGSLFHEQSKKCVQAARKESSDSFVPLLRDCTNSDHQKWFFKE :.. .. : .:.: ...:. .. : .. : : .. :..: :::... XP_011 LKCHHMRGNQLWEYDAETHTLLHIITQSCL-SVNKVADGSQHPTVETCNDSTLQKWLLRN 500 510 520 530 540 550 580 pF1KE0 RML XP_011 YTRMEIFRNIFGNSTDYIL 560 570 >>XP_016858748 (OMIM: 608369) PREDICTED: polypeptide N-a (571 aa) initn: 1165 init1: 657 opt: 1456 Z-score: 1358.2 bits: 261.2 E(85289): 6.5e-69 Smith-Waterman score: 1456; 46.0% identity (70.9% similar) in 509 aa overlap (76-577:58-551) 50 60 70 80 90 100 pF1KE0 GAAEPGPPRTPRPGRREPVMPRPPVPANALGARGEAVRLQLQGEELRLQEESVRLHQINI : :.:: . . .: ...: ...:.:. XP_016 FSECNKCDDKKERSLLPALRAVISRNQEGPGEMGKAVLIPKDDQE-KMKEL-FKINQFNL 30 40 50 60 70 80 110 120 130 140 150 160 pF1KE0 YLSDRISLHRRLPERWNPLCKEKKYDYDNLPRTSVIIAFYNEAWSTLLRTVYSVLETSPD . :: :.:.: ::. :: : : :.:: :::.:.:.::::::::::::::.. :: XP_016 MASDLIALNRSLPDVRLEGCKTKVYP-DELPNTSVVIVFHNEAWSTLLRTVYSVINRSPH 90 100 110 120 130 140 170 180 190 200 210 220 pF1KE0 ILLEEVILVDDYSDREHLKERLANELSGLP-KVRLIRANKREGLVRARLLGASAARGDVL :: ::::::: :.:. :: : : ...: :..:: ..: ::.:::: ::.:..:.:. XP_016 YLLSEVILVDDASERDFLKLTLENYVKNLEVPVKIIRMEERSGLIRARLRGAAASKGQVI 150 160 170 180 190 200 230 240 250 260 270 280 pF1KE0 TFLDCHCECHEGWLEPLLQRIHEEESAVVCPVIDVIDWNTFEYLGNSGEPQIGGFDWRLV :::: :::: ::::::: ::.:....::::.::::. .::::...: . :::.:.: XP_016 TFLDAHCECTLGWLEPLLARIKEDRKTVVCPIIDVISDDTFEYMAGS-DMTYGGFNWKLN 210 220 230 240 250 260 290 300 310 320 330 340 pF1KE0 FTWHTVPERERIRMQSPVDV-IRSPTMAGGLFAVSKKYFEYLGSYDTGMEVWGGENLEFS : :. ::.:: : .. . .:.::::::::.....::: .:.::.::..:::::::.: XP_016 FRWYPVPQREMDRRKGDRTLPVRTPTMAGGLFSIDRNYFEEIGTYDAGMDIWGGENLEMS 270 280 290 300 310 320 350 360 370 380 390 pF1KE0 FRIWQCGGVLETHPCSHVGHVFPKQAPYSRNKALA-----NSVRAAEVWMDEFKELYYHR :::::::: :: :::::::: : .::. . . :. : :::::::::...: XP_016 FRIWQCGGSLEIVTCSHVGHVFRKATPYTFPGGTGHVINKNNRRLAEVWMDEFKDFFYII 330 340 350 360 370 380 400 410 420 430 440 450 pF1KE0 NPRARLEPFGDVTERKQLRDKLQCKDFKWFLETVYPELHVPEDRPGFFGMLQNKGLTDYC .: . .:::. :: ::..:.:: :.:.::..::. ..:. : .: ..: :. : XP_016 SPGVVKVDYGDVSVRKTLRENLKCKPFSWYLENIYPDSQIPR-RYYSLGEIRNVE-TNQC 390 400 410 420 430 440 460 470 480 490 500 510 pF1KE0 FDYNPPDENQIVGHQVILYLCHGMGQNQFFEYTSQKEIRYNTHQPEGCIAVEAGMDTLIM .: ::. :: .. ::::: :: : ::..:::: . . :. : .:: XP_016 LDNMGRKENEKVG----IFNCHGMGGNQVFSYTADKEIRTD----DLCLDVSRLNGPVIM 450 460 470 480 490 520 530 540 550 560 570 pF1KE0 HLCEETAPENQKFILQEDGSLFHEQSKKCVQAARKESSDSFVPLLRDCTNSDHQKWFFKE :.. .. : .:.: ...:. .. : .. : : .. :..: :::... XP_016 LKCHHMRGNQLWEYDAETHTLLHIITQSCL-SVNKVADGSQHPTVETCNDSTLQKWLLRN 500 510 520 530 540 550 580 pF1KE0 RML XP_016 YTRMEIFRNIFGNSTDYIL 560 570 581 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 13:18:41 2016 done: Thu Nov 3 13:18:43 2016 Total Scan time: 11.900 Total Display time: 0.100 Function used was FASTA [36.3.4 Apr, 2011]