FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0384, 489 aa 1>>>pF1KE0384 489 - 489 aa - 489 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.4837+/-0.000347; mu= 6.4048+/- 0.022 mean_var=237.0323+/-48.545, 0's: 0 Z-trim(121.6): 10 B-trim: 878 in 2/56 Lambda= 0.083305 statistics sampled from 38517 (38527) to 38517 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.764), E-opt: 0.2 (0.452), width: 16 Scan time: 11.880 The best scores are: opt bits E(85289) NP_055108 (OMIM: 609474) neuronal pentraxin recept ( 500) 3277 406.6 8.2e-113 NP_002514 (OMIM: 600750) neuronal pentraxin-2 prec ( 431) 1422 183.6 9.6e-46 NP_002513 (OMIM: 602367) neuronal pentraxin-1 prec ( 432) 1266 164.9 4.2e-40 NP_699197 (OMIM: 611691) sushi, von Willebrand fac (3571) 457 68.5 3.5e-10 NP_002843 (OMIM: 602492) pentraxin-related protein ( 381) 347 54.4 6.9e-07 NP_001013680 (OMIM: 613442) pentraxin-4 isoform 2 ( 473) 348 54.6 7.4e-07 NP_001315537 (OMIM: 613442) pentraxin-4 isoform 1 ( 478) 348 54.6 7.4e-07 NP_001315986 (OMIM: 123260) C-reactive protein iso ( 224) 281 46.2 0.00012 NP_000558 (OMIM: 123260) C-reactive protein isofor ( 224) 281 46.2 0.00012 NP_001630 (OMIM: 104770) serum amyloid P-component ( 223) 267 44.5 0.00037 >>NP_055108 (OMIM: 609474) neuronal pentraxin receptor [ (500 aa) initn: 3277 init1: 3277 opt: 3277 Z-score: 2146.3 bits: 406.6 E(85289): 8.2e-113 Smith-Waterman score: 3277; 100.0% identity (100.0% similar) in 489 aa overlap (1-489:12-500) 10 20 30 40 pF1KE0 MLAFLGAVICIIASVPLAASPARALPGGADNASVASGAAASPGPQRSLS ::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MKFLAVLLAAGMLAFLGAVICIIASVPLAASPARALPGGADNASVASGAAASPGPQRSLS 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE0 ALHGAGGSAGPPALPGAPAASAHPLPPGPLFSRFLCTPLAAACPSGAQQGDAAGAAPGER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 ALHGAGGSAGPPALPGAPAASAHPLPPGPLFSRFLCTPLAAACPSGAQQGDAAGAAPGER 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE0 EELLLLQSTAEQLRQTALQQEARIRADQDTIRELTGKLGRCESGLPRGLQGAGPRRDTMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 EELLLLQSTAEQLRQTALQQEARIRADQDTIRELTGKLGRCESGLPRGLQGAGPRRDTMA 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE0 DGPWDSPALILELEDAVRALRDRIDRLEQELPARVNLSAAPAPVSAVPTGLHSKMDQLEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 DGPWDSPALILELEDAVRALRDRIDRLEQELPARVNLSAAPAPVSAVPTGLHSKMDQLEG 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE0 QLLAQVLALEKERVALSHSSRRQRQEVEKELDVLQGRVAELEHGSSAYSPPDAFKISIPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 QLLAQVLALEKERVALSHSSRRQRQEVEKELDVLQGRVAELEHGSSAYSPPDAFKISIPI 250 260 270 280 290 300 290 300 310 320 330 340 pF1KE0 RNNYMYARVRKALPELYAFTACMWLRSRSSGTGQGTPFSYSVPGQANEIVLLEAGHEPME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 RNNYMYARVRKALPELYAFTACMWLRSRSSGTGQGTPFSYSVPGQANEIVLLEAGHEPME 310 320 330 340 350 360 350 360 370 380 390 400 pF1KE0 LLINDKVAQLPLSLKDNGWHHICIAWTTRDGLWSAYQDGELQGSGENLAAWHPIKPHGIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 LLINDKVAQLPLSLKDNGWHHICIAWTTRDGLWSAYQDGELQGSGENLAAWHPIKPHGIL 370 380 390 400 410 420 410 420 430 440 450 460 pF1KE0 ILGQEQDTLGGRFDATQAFVGDIAQFNLWDHALTPAQVLGIANCTAPLLGNVLPWEDKLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 ILGQEQDTLGGRFDATQAFVGDIAQFNLWDHALTPAQVLGIANCTAPLLGNVLPWEDKLV 430 440 450 460 470 480 470 480 pF1KE0 EAFGGATKAAFDVCKGRAKA :::::::::::::::::::: NP_055 EAFGGATKAAFDVCKGRAKA 490 500 >>NP_002514 (OMIM: 600750) neuronal pentraxin-2 precurso (431 aa) initn: 1387 init1: 798 opt: 1422 Z-score: 942.2 bits: 183.6 E(85289): 9.6e-46 Smith-Waterman score: 1422; 51.5% identity (77.4% similar) in 429 aa overlap (66-486:12-427) 40 50 60 70 80 pF1KE0 SGAAASPGPQRSLSALHGAGGSAGPPALPGAPAASAHPLP-PGPLFSRFLCTPLA----- : ::.:. : :: :::.:: : NP_002 MLALLAASVALAVAAGAQDSPAPG---SRFVCTALPPEAVH 10 20 30 90 100 110 120 130 140 pF1KE0 AACPSGAQQGDAAGAAPGEREELLLLQSTAEQLRQTALQQEARIRADQDTIRELTGKLGR :.:: :. :.: . .::: .... :::.:..::. . :....::::::::.: NP_002 AGCPLPAMP--MQGGAQSPEEEL---RAAVLQLRETVVQQKETLGAQREAIRELTGKLAR 40 50 60 70 80 90 150 160 170 180 190 200 pF1KE0 CESGLPRG-LQGAGPR-RDTMADGPWDSPALILELEDAVRALRDRIDRLEQELPARVNLS :: :: : .::: .:::.: : : .. .: ....:.::.. ::..: : :. . NP_002 CE-GLAGGKARGAGATGKDTMGDLPRDPGHVVEQLSRSLQTLKDRLESLEHQLRANVSNA 100 110 120 130 140 150 210 220 230 240 250 260 pF1KE0 AAPAPVSAVPTGLHSKMDQLEGQLLAQVLALEKERVALSHSSRRQRQEVEKELDVLQGRV . :. : :.... .:: ::: .: :: :. : . . .::..:. :..: :: NP_002 GLPGDFREV---LQQRLGELERQLLRKVAELEDEKSLLHNETSAHRQKTESTLNALLQRV 160 170 180 190 200 270 280 290 300 310 320 pF1KE0 AELEHGSSAYSPPDAFKISIPIRNNYMYARVRKALPELYAFTACMWLRSRSSGTGQGTPF .:::.:.::.. :::::.:.:.:.::.:....:.:::::::: :.:::: :.. : :::: NP_002 TELERGNSAFKSPDAFKVSLPLRTNYLYGKIKKTLPELYAFTICLWLRS-SASPGIGTPF 210 220 230 240 250 260 330 340 350 360 370 380 pF1KE0 SYSVPGQANEIVLLEAGHEPMELLINDKVAQLPLSLKDNGWHHICIAWTTRDGLWSAYQD ::.::::::::::.: :..:.::::::::::::: ..:. :::::..::::::.: :.:: NP_002 SYAVPGQANEIVLIEWGNNPIELLINDKVAQLPLFVSDGKWHHICVTWTTRDGMWEAFQD 270 280 290 300 310 320 390 400 410 420 430 440 pF1KE0 GELQGSGENLAAWHPIKPHGILILGQEQDTLGGRFDATQAFVGDIAQFNLWDHALTPAQV :: :.::::: :::::: :.:::::::::.::::::::::::...:::.::..: .. NP_002 GEKLGTGENLAPWHPIKPGGVLILGQEQDTVGGRFDATQAFVGELSQFNIWDRVLRAQEI 330 340 350 360 370 380 450 460 470 480 pF1KE0 LGIANCTAPLLGNVLPWEDKLVEAFGGATKAAFDVCKGRAKA ..::::.. . ::..:: :. :..::::.: ..:. : NP_002 VNIANCSTNMPGNIIPWVDNNVDVFGGASKWPVETCEERLLDL 390 400 410 420 430 >>NP_002513 (OMIM: 602367) neuronal pentraxin-1 precurso (432 aa) initn: 1128 init1: 690 opt: 1266 Z-score: 840.9 bits: 164.9 E(85289): 4.2e-40 Smith-Waterman score: 1266; 48.7% identity (74.8% similar) in 421 aa overlap (77-484:26-429) 50 60 70 80 90 100 pF1KE0 SLSALHGAGGSAGPPALPGAPAASAHPLPPGPLFSRFLCTPLAAACPSGAQQGDAAGAAP :: .::.:: . : :.. :. :: NP_002 MPAGRAARTCALLALCLLGAGAQDFGP--TRFICTSV----PVDADMCAASVAAG 10 20 30 40 110 120 130 140 150 pF1KE0 GEREELLLLQSTAEQLRQTALQQEARIRADQDTIRELTGKLGRCES--------GLPR-- : .: :.:.. :::.:.:::. : ....::::::.::::::: : : NP_002 GAEE----LRSSVLQLRETVLQQKETILSQKETIRELTAKLGRCESQSTLDPGAGEARAG 50 60 70 80 90 100 160 170 180 190 200 210 pF1KE0 -GLQGAGPRRDTMADGPWDSPALIL-ELEDAVRALRDRIDRLEQELPARVNLSAAPAPVS : . : ..::.: : : .: .....:. :.. ::: .:.: :. .. NP_002 GGRKQPGSGKNTMGDLSRTPAAETLSQLGQTLQSLKTRLENLEQY--SRLNSSSQTNSLK 110 120 130 140 150 160 220 230 240 250 260 270 pF1KE0 AVPTGLHSKMDQLEGQLLAQVLALEKERVALSHSSRRQRQEVEKELDVLQGRVAELEHGS . :.::.:.:: :.:..: .::. . . ... ..: ..: : :. :..:::.:. NP_002 DL---LQSKIDELERQVLSRVNTLEEGKGG-PRNDTEERVKIETALTSLHQRISELEKGQ 170 180 190 200 210 280 290 300 310 320 330 pF1KE0 SAYSPPDAFKISIPIRNNYMYARVRKALPELYAFTACMWLRSRSSGTGQGTPFSYSVPGQ . : : :....:.:.:::::.:.:.:::.::::.::::.: :. : ::::::.:::: NP_002 KDNRPGDKFQLTFPLRTNYMYAKVKKSLPEMYAFTVCMWLKS-SATPGVGTPFSYAVPGQ 220 230 240 250 260 270 340 350 360 370 380 390 pF1KE0 ANEIVLLEAGHEPMELLINDKVAQLPLSLKDNGWHHICIAWTTRDGLWSAYQDGELQGSG :::.::.: :..:::.:::::::.::. ..:. :::::..::::::.: ::::: ::: NP_002 ANELVLIEWGNNPMEILINDKVAKLPFVINDGKWHHICVTWTTRDGVWEAYQDGTQGGSG 280 290 300 310 320 330 400 410 420 430 440 450 pF1KE0 ENLAAWHPIKPHGILILGQEQDTLGGRFDATQAFVGDIAQFNLWDHALTPAQVLGIANC- :::: .:::::.:.:.:::::::::: :::::::::..:.::.::. :::..: ..:.: NP_002 ENLAPYHPIKPQGVLVLGQEQDTLGGGFDATQAFVGELAHFNIWDRKLTPGEVYNLATCS 340 350 360 370 380 390 460 470 480 pF1KE0 TAPLLGNVLPWEDKLVEAFGGATKAAFDVCKGRAKA : : :::. : .. .: .::::: .:..:. NP_002 TKALSGNVIAWAESHIEIYGGATKWTFEACRQIN 400 410 420 430 >>NP_699197 (OMIM: 611691) sushi, von Willebrand factor (3571 aa) initn: 376 init1: 331 opt: 457 Z-score: 303.8 bits: 68.5 E(85289): 3.5e-10 Smith-Waterman score: 457; 39.0% identity (69.2% similar) in 195 aa overlap (283-473:1426-1617) 260 270 280 290 300 310 pF1KE0 RQEVEKELDVLQGRVAELEHGSSAYSPPDAFKISIPIRNNYMYARVRKALPELYAFTACM :.... . . : :. . :: :.:.: . NP_699 ATCVDELNSYSCKCQPGFSGKRCETEQSTGFNLDFEVSGIYGYVMLDGMLPSLHALTCTF 1400 1410 1420 1430 1440 1450 320 330 340 350 360 370 pF1KE0 WLRSRSSGTGQGTPFSYSVPGQANEIVLLEAGHEPMELLIN--DKVAQLPLSLKDNGWHH :..: :. . :::.::.: . ... .:: . .. : .: .:... : :..:. ::: NP_699 WMKS-SDDMNYGTPISYAVDNGSDNTLLL-TDYNGWVLYVNGREKITNCP-SVNDGRWHH 1460 1470 1480 1490 1500 1510 380 390 400 410 420 430 pF1KE0 ICIAWTTRDGLWSAYQDGELQGSGENLAAWHPIKPHGILILGQEQDTLGGRFDATQAFVG : :.::. .:.:..: ::.:. .: .:.. :: : :.:::::: : :. ...::: NP_699 IAITWTSANGIWKVYIDGKLSDGGAGLSVGLPIPGGGALVLGQEQDKKGEGFSPAESFVG 1520 1530 1540 1550 1560 1570 440 450 460 470 480 pF1KE0 DIAQFNLWDHALTPAQVLGIA-NCTAPLL-GNVLPWEDKLVEAFGGATKAAFDVCKGRAK .:.:.::::..:.: :: ..: .: : :::: : : : : NP_699 SISQLNLWDYVLSPQQVKSLATSCPEELSKGNVLAWPDFLSGIVGKVKIDSKSIFCSDCP 1580 1590 1600 1610 1620 1630 pF1KE0 A NP_699 RLGGSVPHLRTASEDLKPGSKVNLFCDPGFQLVGNPVQYCLNQGQWTQPLPHCERISCGV 1640 1650 1660 1670 1680 1690 >>NP_002843 (OMIM: 602492) pentraxin-related protein PTX (381 aa) initn: 198 init1: 97 opt: 347 Z-score: 244.7 bits: 54.4 E(85289): 6.9e-07 Smith-Waterman score: 356; 28.3% identity (58.3% similar) in 321 aa overlap (178-475:72-377) 150 160 170 180 190 200 pF1KE0 GRCESGLPRGLQGAGPRRDTMADGPWDSPALILELEDAVRALRDRIDRLEQELPARVNLS ..:. : : :: ...::..:: .. NP_002 EDPTPCACGQEHSEWDKLFIMLENSQMRERMLLQATDDV--LRGELQRLREELGRLAESL 50 60 70 80 90 210 220 230 240 250 pF1KE0 AAP-APVSAVPTGLHSKMDQL------EGQLLAQVLALEKERV-----ALSHSSRRQRQE : : :: . . . : : .:.: :. ::.. . : .: ::. .. :: NP_002 ARPCAPGAPAEARLTSALDELLQATRDAGRRLARMEGAEAQRPEEAGRALAAVLEELRQ- 100 110 120 130 140 150 260 270 280 290 300 310 pF1KE0 VEKELDVLQGRVAELEHGSSAYSPPDA-FKISIPIRNNYMYARVRKALP-ELYAFTACMW .. .: ..:: .:. .. : : .:.:.. ... :. . : .: .:.::.: NP_002 TRADLHAVQGWAAR------SWLPAGCETAILFPMRSKKIFGSVHPVRPMRLESFSACIW 160 170 180 190 200 210 320 330 340 350 360 pF1KE0 LRSRSSGTGQGTPFSYSVPGQANEIVLLEAGHEPMELLI----NDKVAQLPLSLKDNGWH ... .. .. :::.. . :: : ... . ... : ::. .:: . : NP_002 VKA-TDVLNKTILFSYGTKRNPYEI-QLYLSYQSIVFVVGGEENKLVAEAMVSL--GRWT 220 230 240 250 260 370 380 390 400 410 420 pF1KE0 HICIAWTTRDGLWSAYQDGELQGSGENLAAWHPIKPHGILILGQEQD--TLGGRFDATQA :.: .:....:: : . .::: .. ..:. : . ::: .:::.. .:: :: : : NP_002 HLCGTWNSEEGLTSLWVNGELAATTVEMATGHIVPEGGILQIGQEKNGCCVGGGFDETLA 270 280 290 300 310 320 430 440 450 460 470 480 pF1KE0 FVGDIAQFNLWDHALTPAQVL---GIANCTAPLLGNVLPWEDKLVEAFGGATKAAFDVCK : : .. ::.:: .:. .. : .: . ::.. : .. ::: NP_002 FSGRLTGFNIWDSVLSNEEIRETGGAESCH--IRGNIVGWGVTEIQPHGGAQYVS 330 340 350 360 370 380 pF1KE0 GRAKA >>NP_001013680 (OMIM: 613442) pentraxin-4 isoform 2 [Hom (473 aa) initn: 313 init1: 276 opt: 348 Z-score: 244.1 bits: 54.6 E(85289): 7.4e-07 Smith-Waterman score: 392; 28.2% identity (54.6% similar) in 401 aa overlap (115-486:92-471) 90 100 110 120 130 140 pF1KE0 CTPLAAACPSGAQQGDAAGAAPGEREELLLLQSTAEQLRQTALQQEARIRADQDTIRELT .:. ::. . . . : : . .: : NP_001 NVSYNVDVRFRSLAEESQAVAQAVNRSQASVQGELAQLKAWVRKLQRRGRKVDTRLRALD 70 80 90 100 110 120 150 160 170 180 190 200 pF1KE0 GKLGRCESGLPRGLQGAGPRRDTMADGPWDSPALILELEDAVRALRDRIDRLEQELPARV ::. . : .. .::.. :. . .:: :.. :. :: .::. NP_001 LTLGERSQQRARERKAHKAQRDALQDS-------LARLEGLVHSQGARLAALEGRLPVAH 130 140 150 160 170 210 220 230 240 250 260 pF1KE0 NLSAAPAPVSAVPTGLHSKMDQLEGQLLAQVLALEKERVALSHSSRRQRQEVEKELDVLQ .:: .: . ::: . . .: : :...: : .:. .: . :: NP_001 PGTAALGP-ALVPTPTQPE------ELGPTSLKLQRDRQELRAASE-HRGPPQDSSAPLQ 180 190 200 210 220 270 280 290 300 pF1KE0 GRVAELEHGS----SAYSPPD----AFKISIP-----IRNNYMY--ARVRKAL---P--- :: :: :. .: : :.. ..: . . .. : .:... : NP_001 GRREPPASGSHRVLSGTAPKDPRQQAWSPQVPGEICGVGPTLVFPNASTRNVVFLSPGFV 230 240 250 260 270 280 310 320 330 340 350 pF1KE0 -ELYAFTACMWLRSRSSGTGQGTPFSYSVPGQANEIVLLEAGHEPM-----ELLINDKV- : :.. : :.:. .:: :: .::.. . :..:: :.. . ...:.: . NP_001 TALRALSFCSWVRT-ASGR-LGTLLSYATEDNDNKLVL--HGRDSLLPGSIHFVIGDPAF 290 300 310 320 330 340 360 370 380 390 400 410 pF1KE0 AQLPLSLKDNG-WHHICIAWTTRDGLWSAYQDGELQGSGENLAAWHPIKPHGILILGQEQ .:::.: .: :::::. ::. .: . . : .: ..: . . : : : :.::::: NP_001 RELPLQLLLDGQWHHICVIWTSTQGRYWLHVDRRLVATGSRFREGYEIPPGGSLVLGQEQ 350 360 370 380 390 400 420 430 440 450 460 470 pF1KE0 DTLGGRFDATQAFVGDIAQFNLWDHALTPAQVLGIANCTAPLLGNVLPWEDKLVEAFGGA :..:: ::...::::... . .::.::.:..: ..: : .: . . :: NP_001 DSVGGGFDSSEAFVGSMSGLAIWDRALVPGEVANLAIGKEFPTGAILTLANAALA--GGF 410 420 430 440 450 460 480 pF1KE0 TKAAFDVCKGRAKA ...: .: : NP_001 VQGANCTCLERCP 470 >>NP_001315537 (OMIM: 613442) pentraxin-4 isoform 1 prec (478 aa) initn: 313 init1: 276 opt: 348 Z-score: 244.1 bits: 54.6 E(85289): 7.4e-07 Smith-Waterman score: 392; 28.2% identity (54.6% similar) in 401 aa overlap (115-486:97-476) 90 100 110 120 130 140 pF1KE0 CTPLAAACPSGAQQGDAAGAAPGEREELLLLQSTAEQLRQTALQQEARIRADQDTIRELT .:. ::. . . . : : . .: : NP_001 NVSYNVDVRFRSLAEESQAVAQAVNRSQASVQGELAQLKAWVRKLQRRGRKVDTRLRALD 70 80 90 100 110 120 150 160 170 180 190 200 pF1KE0 GKLGRCESGLPRGLQGAGPRRDTMADGPWDSPALILELEDAVRALRDRIDRLEQELPARV ::. . : .. .::.. :. . .:: :.. :. :: .::. NP_001 LTLGERSQQRARERKAHKAQRDALQDS-------LARLEGLVHSQGARLAALEGRLPVAH 130 140 150 160 170 210 220 230 240 250 260 pF1KE0 NLSAAPAPVSAVPTGLHSKMDQLEGQLLAQVLALEKERVALSHSSRRQRQEVEKELDVLQ .:: .: . ::: . . .: : :...: : .:. .: . :: NP_001 PGTAALGP-ALVPTPTQPE------ELGPTSLKLQRDRQELRAASE-HRGPPQDSSAPLQ 180 190 200 210 220 230 270 280 290 300 pF1KE0 GRVAELEHGS----SAYSPPD----AFKISIP-----IRNNYMY--ARVRKAL---P--- :: :: :. .: : :.. ..: . . .. : .:... : NP_001 GRREPPASGSHRVLSGTAPKDPRQQAWSPQVPGEICGVGPTLVFPNASTRNVVFLSPGFV 240 250 260 270 280 290 310 320 330 340 350 pF1KE0 -ELYAFTACMWLRSRSSGTGQGTPFSYSVPGQANEIVLLEAGHEPM-----ELLINDKV- : :.. : :.:. .:: :: .::.. . :..:: :.. . ...:.: . NP_001 TALRALSFCSWVRT-ASGR-LGTLLSYATEDNDNKLVL--HGRDSLLPGSIHFVIGDPAF 300 310 320 330 340 360 370 380 390 400 410 pF1KE0 AQLPLSLKDNG-WHHICIAWTTRDGLWSAYQDGELQGSGENLAAWHPIKPHGILILGQEQ .:::.: .: :::::. ::. .: . . : .: ..: . . : : : :.::::: NP_001 RELPLQLLLDGQWHHICVIWTSTQGRYWLHVDRRLVATGSRFREGYEIPPGGSLVLGQEQ 350 360 370 380 390 400 420 430 440 450 460 470 pF1KE0 DTLGGRFDATQAFVGDIAQFNLWDHALTPAQVLGIANCTAPLLGNVLPWEDKLVEAFGGA :..:: ::...::::... . .::.::.:..: ..: : .: . . :: NP_001 DSVGGGFDSSEAFVGSMSGLAIWDRALVPGEVANLAIGKEFPTGAILTLANAALA--GGF 410 420 430 440 450 460 480 pF1KE0 TKAAFDVCKGRAKA ...: .: : NP_001 VQGANCTCLERCP 470 >>NP_001315986 (OMIM: 123260) C-reactive protein isoform (224 aa) initn: 255 init1: 165 opt: 281 Z-score: 204.7 bits: 46.2 E(85289): 0.00012 Smith-Waterman score: 281; 27.6% identity (59.6% similar) in 203 aa overlap (274-473:14-214) 250 260 270 280 290 300 pF1KE0 ALSHSSRRQRQEVEKELDVLQGRVAELEHGSSAYSPPDAFKISI--PIRNNYMYARVRKA : :.. : . .. : ... :. .. NP_001 MEKLLCFLVLTSLSHAFGQTDMSRKAFVFPKESDTSYVSLKAP 10 20 30 40 310 320 330 340 350 360 pF1KE0 LPE-LYAFTACMWLRSRSSGTGQGTPFSYSVPGQANEIVLLEAGHEPMELLINDKVAQLP : . : :::.:. . .. :.: . :::.. : :::... . . . .. . . NP_001 LTKPLKAFTVCLHFYTELSSTRGYSIFSYATKRQDNEILIFWSKDIGYSFTVGGSEILFE 50 60 70 80 90 100 370 380 390 400 410 420 pF1KE0 LSLKDNGWHHICIAWTTRDGLWSAYQDGELQGSGENLAAWHPIKPHGILILGQEQDTLGG . . ::: .: . .:. . ::. . ..: . . .. .:::::::..:: NP_001 VPEVTVAPVHICTSWESASGIVEFWVDGKPR-VRKSLKKGYTVGAEASIILGQEQDSFGG 110 120 130 140 150 160 430 440 450 460 470 480 pF1KE0 RFDATQAFVGDIAQFNLWDHALTPAQVLGIANCTAPLLGNVLPWEDKLVEAFGGATKAAF :...:..::::.. :.:: .:.: .. : .:. ::: :. :. : NP_001 NFEGSQSLVGDIGNVNMWDFVLSPDEINTIY-LGGPFSPNVLNWRALKYEVQGEVFTKPQ 170 180 190 200 210 220 pF1KE0 DVCKGRAKA NP_001 LWP >>NP_000558 (OMIM: 123260) C-reactive protein isoform 1 (224 aa) initn: 255 init1: 165 opt: 281 Z-score: 204.7 bits: 46.2 E(85289): 0.00012 Smith-Waterman score: 281; 27.6% identity (59.6% similar) in 203 aa overlap (274-473:14-214) 250 260 270 280 290 300 pF1KE0 ALSHSSRRQRQEVEKELDVLQGRVAELEHGSSAYSPPDAFKISI--PIRNNYMYARVRKA : :.. : . .. : ... :. .. NP_000 MEKLLCFLVLTSLSHAFGQTDMSRKAFVFPKESDTSYVSLKAP 10 20 30 40 310 320 330 340 350 360 pF1KE0 LPE-LYAFTACMWLRSRSSGTGQGTPFSYSVPGQANEIVLLEAGHEPMELLINDKVAQLP : . : :::.:. . .. :.: . :::.. : :::... . . . .. . . NP_000 LTKPLKAFTVCLHFYTELSSTRGYSIFSYATKRQDNEILIFWSKDIGYSFTVGGSEILFE 50 60 70 80 90 100 370 380 390 400 410 420 pF1KE0 LSLKDNGWHHICIAWTTRDGLWSAYQDGELQGSGENLAAWHPIKPHGILILGQEQDTLGG . . ::: .: . .:. . ::. . ..: . . .. .:::::::..:: NP_000 VPEVTVAPVHICTSWESASGIVEFWVDGKPR-VRKSLKKGYTVGAEASIILGQEQDSFGG 110 120 130 140 150 160 430 440 450 460 470 480 pF1KE0 RFDATQAFVGDIAQFNLWDHALTPAQVLGIANCTAPLLGNVLPWEDKLVEAFGGATKAAF :...:..::::.. :.:: .:.: .. : .:. ::: :. :. : NP_000 NFEGSQSLVGDIGNVNMWDFVLSPDEINTIY-LGGPFSPNVLNWRALKYEVQGEVFTKPQ 170 180 190 200 210 220 pF1KE0 DVCKGRAKA NP_000 LWP >>NP_001630 (OMIM: 104770) serum amyloid P-component pre (223 aa) initn: 190 init1: 159 opt: 267 Z-score: 195.7 bits: 44.5 E(85289): 0.00037 Smith-Waterman score: 267; 30.9% identity (61.1% similar) in 162 aa overlap (305-465:49-205) 280 290 300 310 320 330 pF1KE0 SAYSPPDAFKISIPIRNNYMYARVRKALPELYAFTACMWLRSRSSGTGQGTPFSYSVPGQ : :: : .:. :. . . :::.. :. NP_001 AHTDLSGKVFVFPRESVTDHVNLITPLEKPLQNFTLC--FRAYSDLSRAYSLFSYNTQGR 20 30 40 50 60 70 340 350 360 370 380 390 pF1KE0 ANEIVLLEAGHEPMELLINDKVAQLPLSLKDNGWHHICIAWTTRDGLWSAYQDGE-LQGS ::... . . : :. . . . : . :::..: . .:. . .: : . NP_001 DNELLVYKERVGEYSLYIGRHKVTSKVIEKFPAPVHICVSWESSSGIAEFWINGTPLVKK 80 90 100 110 120 130 400 410 420 430 440 450 pF1KE0 GENLAAWHPIKPHGILILGQEQDTLGGRFDATQAFVGDIAQFNLWDHALTPAQVLGIANC : . . .:. ..::::::. ::.:: .:.:::.:... .:: .: : ..:. . NP_001 GLRQGYFVEAQPK--IVLGQEQDSYGGKFDRSQSFVGEIGDLYMWDSVLPPENILSAYQG 140 150 160 170 180 190 460 470 480 pF1KE0 TAPLLGNVLPWEDKLVEAFGGATKAAFDVCKGRAKA : :: .:.: :. NP_001 T-PLPANILDWQALNYEIRGYVIIKPLVWV 200 210 220 489 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 13:02:26 2016 done: Thu Nov 3 13:02:28 2016 Total Scan time: 11.880 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]