FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0385, 765 aa 1>>>pF1KE0385 765 - 765 aa - 765 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.3474+/-0.000394; mu= 20.5416+/- 0.025 mean_var=74.3447+/-15.571, 0's: 0 Z-trim(111.5): 77 B-trim: 1277 in 1/52 Lambda= 0.148747 statistics sampled from 20018 (20097) to 20018 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.575), E-opt: 0.2 (0.236), width: 16 Scan time: 10.980 The best scores are: opt bits E(85289) NP_075053 (OMIM: 607819) zinc transporter 5 isofor ( 765) 5065 1097.0 0 XP_005248626 (OMIM: 607819) PREDICTED: zinc transp ( 724) 4611 999.5 0 XP_006714735 (OMIM: 607819) PREDICTED: zinc transp ( 722) 4424 959.4 0 XP_016865238 (OMIM: 607819) PREDICTED: zinc transp ( 681) 3970 862.0 0 XP_016855890 (OMIM: 611149) PREDICTED: zinc transp ( 289) 642 147.5 7.3e-35 NP_001138356 (OMIM: 611149) zinc transporter 7 [Ho ( 376) 642 147.6 9e-35 NP_598003 (OMIM: 611149) zinc transporter 7 [Homo ( 376) 642 147.6 9e-35 XP_016855889 (OMIM: 611149) PREDICTED: zinc transp ( 376) 642 147.6 9e-35 NP_076960 (OMIM: 607819) zinc transporter 5 isofor ( 118) 602 138.7 1.4e-32 XP_011539081 (OMIM: 611149) PREDICTED: zinc transp ( 306) 516 120.5 1.1e-26 XP_006711500 (OMIM: 611146,613280) PREDICTED: zinc ( 422) 427 101.5 7.6e-21 NP_061183 (OMIM: 611146,613280) zinc transporter 1 ( 485) 280 70.0 2.7e-11 XP_016878049 (OMIM: 602095) PREDICTED: zinc transp ( 429) 264 66.5 2.6e-10 NP_037441 (OMIM: 602095) zinc transporter 4 isofor ( 429) 264 66.5 2.6e-10 XP_011520299 (OMIM: 602095) PREDICTED: zinc transp ( 429) 264 66.5 2.6e-10 XP_016859951 (OMIM: 611148) PREDICTED: zinc transp ( 387) 240 61.4 8.6e-09 NP_001317405 (OMIM: 611148) zinc transporter 6 iso ( 387) 240 61.4 8.6e-09 XP_011531264 (OMIM: 611148) PREDICTED: zinc transp ( 387) 240 61.4 8.6e-09 NP_001317408 (OMIM: 611148) zinc transporter 6 iso ( 412) 240 61.4 9e-09 NP_001180444 (OMIM: 611148) zinc transporter 6 iso ( 432) 240 61.4 9.4e-09 NP_060434 (OMIM: 611148) zinc transporter 6 isofor ( 461) 240 61.4 9.9e-09 NP_001180442 (OMIM: 611148) zinc transporter 6 iso ( 501) 240 61.4 1.1e-08 NP_001317406 (OMIM: 611148) zinc transporter 6 iso ( 264) 236 60.4 1.1e-08 NP_001317407 (OMIM: 611148) zinc transporter 6 iso ( 264) 236 60.4 1.1e-08 XP_006712111 (OMIM: 611148) PREDICTED: zinc transp ( 264) 236 60.4 1.1e-08 NP_001166285 (OMIM: 125853,611145) zinc transporte ( 320) 231 59.4 2.8e-08 NP_001166284 (OMIM: 125853,611145) zinc transporte ( 320) 231 59.4 2.8e-08 NP_001166286 (OMIM: 125853,611145) zinc transporte ( 320) 231 59.4 2.8e-08 NP_001166282 (OMIM: 125853,611145) zinc transporte ( 320) 231 59.4 2.8e-08 NP_115902 (OMIM: 608118,609617) zinc transporter 2 ( 323) 231 59.4 2.8e-08 NP_776250 (OMIM: 125853,611145) zinc transporter 8 ( 369) 231 59.4 3.2e-08 NP_001004434 (OMIM: 608118,609617) zinc transporte ( 372) 227 58.5 5.8e-08 NP_001238898 (OMIM: 607819) zinc transporter 5 iso ( 77) 210 54.4 2.1e-07 XP_016857173 (OMIM: 611146,613280) PREDICTED: zinc ( 326) 207 54.2 1e-06 XP_011531405 (OMIM: 602878) PREDICTED: zinc transp ( 274) 187 49.9 1.7e-05 XP_011531404 (OMIM: 602878) PREDICTED: zinc transp ( 315) 187 49.9 1.9e-05 XP_016859955 (OMIM: 611148) PREDICTED: zinc transp ( 228) 183 49.0 2.7e-05 NP_001180443 (OMIM: 611148) zinc transporter 6 iso ( 438) 183 49.2 4.6e-05 XP_016859952 (OMIM: 611148) PREDICTED: zinc transp ( 340) 162 44.6 0.00085 XP_011531265 (OMIM: 611148) PREDICTED: zinc transp ( 362) 162 44.6 0.00089 NP_001305879 (OMIM: 602878) zinc transporter 3 iso ( 375) 158 43.7 0.0017 NP_001305880 (OMIM: 602878) zinc transporter 3 iso ( 375) 158 43.7 0.0017 NP_001305878 (OMIM: 602878) zinc transporter 3 iso ( 383) 158 43.8 0.0017 NP_003450 (OMIM: 602878) zinc transporter 3 a [Hom ( 388) 158 43.8 0.0017 XP_016878051 (OMIM: 602095) PREDICTED: zinc transp ( 187) 154 42.7 0.0017 NP_001307965 (OMIM: 602095) zinc transporter 4 iso ( 187) 154 42.7 0.0017 XP_016878050 (OMIM: 602095) PREDICTED: zinc transp ( 199) 154 42.7 0.0018 NP_001070984 (OMIM: 601416) zinc transporter SLC39 ( 469) 155 43.2 0.0031 NP_008910 (OMIM: 601416) zinc transporter SLC39A7 ( 469) 155 43.2 0.0031 >>NP_075053 (OMIM: 607819) zinc transporter 5 isoform 1 (765 aa) initn: 5065 init1: 5065 opt: 5065 Z-score: 5870.5 bits: 1097.0 E(85289): 0 Smith-Waterman score: 5065; 100.0% identity (100.0% similar) in 765 aa overlap (1-765:1-765) 10 20 30 40 50 60 pF1KE0 MEEKYGGDVLAGPGGGGGLGPVDVPSARLTKYIVLLCFTKFLKAVGLFESYDLLKAVHIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_075 MEEKYGGDVLAGPGGGGGLGPVDVPSARLTKYIVLLCFTKFLKAVGLFESYDLLKAVHIV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 QFIFILKLGTAFFMVLFQKPFSSGKTITKHQWIKIFKHAVAGCIISLLWFFGLTLCGPLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_075 QFIFILKLGTAFFMVLFQKPFSSGKTITKHQWIKIFKHAVAGCIISLLWFFGLTLCGPLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 TLLLFEHSDIVVISLLSVLFTSSGGGPAKTRGAAFFIIAVICLLLFDNDDLMAKMAEHPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_075 TLLLFEHSDIVVISLLSVLFTSSGGGPAKTRGAAFFIIAVICLLLFDNDDLMAKMAEHPE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 GHHDSALTHMLYTAIAFLGVADHKGGVLLLVLALCCKVGFHTASRKLSVDVGGAKRLQAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_075 GHHDSALTHMLYTAIAFLGVADHKGGVLLLVLALCCKVGFHTASRKLSVDVGGAKRLQAL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 SHLVSVLLLCPWVIVLSVTTESKVESWFSLIMPFATVIFFVMILDFYVDSICSVKMEVSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_075 SHLVSVLLLCPWVIVLSVTTESKVESWFSLIMPFATVIFFVMILDFYVDSICSVKMEVSK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 CARYGSFPIFISALLFGNFWTHPITDQLRAMNKAAHQESTEHVLSGGVVVSAIFFILSAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_075 CARYGSFPIFISALLFGNFWTHPITDQLRAMNKAAHQESTEHVLSGGVVVSAIFFILSAN 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 ILSSPSKRGQKGTLIGYSPEGTPLYNFMGDAFQHSSQSIPRFIKESLKQILEESDSRQIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_075 ILSSPSKRGQKGTLIGYSPEGTPLYNFMGDAFQHSSQSIPRFIKESLKQILEESDSRQIF 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE0 YFLCLNLLFTFVELFYGVLTNSLGLISDGFHMLFDCSALVMGLFAALMSRWKATRIFSYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_075 YFLCLNLLFTFVELFYGVLTNSLGLISDGFHMLFDCSALVMGLFAALMSRWKATRIFSYG 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE0 YGRIEILSGFINGLFLIVIAFFVFMESVARLIDPPELDTHMLTPVSVGGLIVNLIGICAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_075 YGRIEILSGFINGLFLIVIAFFVFMESVARLIDPPELDTHMLTPVSVGGLIVNLIGICAF 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE0 SHAHSHAHGASQGSCHSSDHSHSHHMHGHSDHGHGHSHGSAGGGMNANMRGVFLHVLADT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_075 SHAHSHAHGASQGSCHSSDHSHSHHMHGHSDHGHGHSHGSAGGGMNANMRGVFLHVLADT 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE0 LGSIGVIVSTVLIEQFGWFIADPLCSLFIAILIFLSVVPLIKDACQVLLLRLPPEYEKEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_075 LGSIGVIVSTVLIEQFGWFIADPLCSLFIAILIFLSVVPLIKDACQVLLLRLPPEYEKEL 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE0 HIALEKIQKIEGLISYRDPHFWRHSASIVAGTIHIQVTSDVLEQRIVQQVTGILKDAGVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_075 HIALEKIQKIEGLISYRDPHFWRHSASIVAGTIHIQVTSDVLEQRIVQQVTGILKDAGVN 670 680 690 700 710 720 730 740 750 760 pF1KE0 NLTIQVEKEAYFQHMSGLSTGFHDVLAMTKQMESMKYCKDGTYIM ::::::::::::::::::::::::::::::::::::::::::::: NP_075 NLTIQVEKEAYFQHMSGLSTGFHDVLAMTKQMESMKYCKDGTYIM 730 740 750 760 >>XP_005248626 (OMIM: 607819) PREDICTED: zinc transporte (724 aa) initn: 4611 init1: 4611 opt: 4611 Z-score: 5344.3 bits: 999.5 E(85289): 0 Smith-Waterman score: 4717; 94.6% identity (94.6% similar) in 765 aa overlap (1-765:1-724) 10 20 30 40 50 60 pF1KE0 MEEKYGGDVLAGPGGGGGLGPVDVPSARLTKYIVLLCFTKFLKAVGLFESYDLLKAVHIV :::::::::::::::::::::::::::: XP_005 MEEKYGGDVLAGPGGGGGLGPVDVPSAR-------------------------------- 10 20 70 80 90 100 110 120 pF1KE0 QFIFILKLGTAFFMVLFQKPFSSGKTITKHQWIKIFKHAVAGCIISLLWFFGLTLCGPLR ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ---------TAFFMVLFQKPFSSGKTITKHQWIKIFKHAVAGCIISLLWFFGLTLCGPLR 30 40 50 60 70 130 140 150 160 170 180 pF1KE0 TLLLFEHSDIVVISLLSVLFTSSGGGPAKTRGAAFFIIAVICLLLFDNDDLMAKMAEHPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TLLLFEHSDIVVISLLSVLFTSSGGGPAKTRGAAFFIIAVICLLLFDNDDLMAKMAEHPE 80 90 100 110 120 130 190 200 210 220 230 240 pF1KE0 GHHDSALTHMLYTAIAFLGVADHKGGVLLLVLALCCKVGFHTASRKLSVDVGGAKRLQAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GHHDSALTHMLYTAIAFLGVADHKGGVLLLVLALCCKVGFHTASRKLSVDVGGAKRLQAL 140 150 160 170 180 190 250 260 270 280 290 300 pF1KE0 SHLVSVLLLCPWVIVLSVTTESKVESWFSLIMPFATVIFFVMILDFYVDSICSVKMEVSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SHLVSVLLLCPWVIVLSVTTESKVESWFSLIMPFATVIFFVMILDFYVDSICSVKMEVSK 200 210 220 230 240 250 310 320 330 340 350 360 pF1KE0 CARYGSFPIFISALLFGNFWTHPITDQLRAMNKAAHQESTEHVLSGGVVVSAIFFILSAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CARYGSFPIFISALLFGNFWTHPITDQLRAMNKAAHQESTEHVLSGGVVVSAIFFILSAN 260 270 280 290 300 310 370 380 390 400 410 420 pF1KE0 ILSSPSKRGQKGTLIGYSPEGTPLYNFMGDAFQHSSQSIPRFIKESLKQILEESDSRQIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ILSSPSKRGQKGTLIGYSPEGTPLYNFMGDAFQHSSQSIPRFIKESLKQILEESDSRQIF 320 330 340 350 360 370 430 440 450 460 470 480 pF1KE0 YFLCLNLLFTFVELFYGVLTNSLGLISDGFHMLFDCSALVMGLFAALMSRWKATRIFSYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YFLCLNLLFTFVELFYGVLTNSLGLISDGFHMLFDCSALVMGLFAALMSRWKATRIFSYG 380 390 400 410 420 430 490 500 510 520 530 540 pF1KE0 YGRIEILSGFINGLFLIVIAFFVFMESVARLIDPPELDTHMLTPVSVGGLIVNLIGICAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YGRIEILSGFINGLFLIVIAFFVFMESVARLIDPPELDTHMLTPVSVGGLIVNLIGICAF 440 450 460 470 480 490 550 560 570 580 590 600 pF1KE0 SHAHSHAHGASQGSCHSSDHSHSHHMHGHSDHGHGHSHGSAGGGMNANMRGVFLHVLADT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SHAHSHAHGASQGSCHSSDHSHSHHMHGHSDHGHGHSHGSAGGGMNANMRGVFLHVLADT 500 510 520 530 540 550 610 620 630 640 650 660 pF1KE0 LGSIGVIVSTVLIEQFGWFIADPLCSLFIAILIFLSVVPLIKDACQVLLLRLPPEYEKEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LGSIGVIVSTVLIEQFGWFIADPLCSLFIAILIFLSVVPLIKDACQVLLLRLPPEYEKEL 560 570 580 590 600 610 670 680 690 700 710 720 pF1KE0 HIALEKIQKIEGLISYRDPHFWRHSASIVAGTIHIQVTSDVLEQRIVQQVTGILKDAGVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HIALEKIQKIEGLISYRDPHFWRHSASIVAGTIHIQVTSDVLEQRIVQQVTGILKDAGVN 620 630 640 650 660 670 730 740 750 760 pF1KE0 NLTIQVEKEAYFQHMSGLSTGFHDVLAMTKQMESMKYCKDGTYIM ::::::::::::::::::::::::::::::::::::::::::::: XP_005 NLTIQVEKEAYFQHMSGLSTGFHDVLAMTKQMESMKYCKDGTYIM 680 690 700 710 720 >>XP_006714735 (OMIM: 607819) PREDICTED: zinc transporte (722 aa) initn: 4796 init1: 4424 opt: 4424 Z-score: 5127.5 bits: 959.4 E(85289): 0 Smith-Waterman score: 4687; 94.4% identity (94.4% similar) in 765 aa overlap (1-765:1-722) 10 20 30 40 50 60 pF1KE0 MEEKYGGDVLAGPGGGGGLGPVDVPSARLTKYIVLLCFTKFLKAVGLFESYDLLKAVHIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MEEKYGGDVLAGPGGGGGLGPVDVPSARLTKYIVLLCFTKFLKAVGLFESYDLLKAVHIV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 QFIFILKLGTAFFMVLFQKPFSSGKTITKHQWIKIFKHAVAGCIISLLWFFGLTLCGPLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QFIFILKLGTAFFMVLFQKPFSSGKTITKHQWIKIFKHAVAGCIISLLWFFGLTLCGPLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 TLLLFEHSDIVVISLLSVLFTSSGGGPAKTRGAAFFIIAVICLLLFDNDDLMAKMAEHPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TLLLFEHSDIVVISLLSVLFTSSGGGPAKTRGAAFFIIAVICLLLFDNDDLMAKMAEHPE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 GHHDSALTHMLYTAIAFLGVADHKGGVLLLVLALCCKVGFHTASRKLSVDVGGAKRLQAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GHHDSALTHMLYTAIAFLGVADHKGGVLLLVLALCCKVGFHTASRKLSVDVGGAKRLQAL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 SHLVSVLLLCPWVIVLSVTTESKVESWFSLIMPFATVIFFVMILDFYVDSICSVKMEVSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SHLVSVLLLCPWVIVLSVTTESKVESWFSLIMPFATVIFFVMILDFYVDSICSVKMEVSK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 CARYGSFPIFISALLFGNFWTHPITDQLRAMNKAAHQESTEHVLSGGVVVSAIFFILSAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 CARYGSFPIFISALLFGNFWTHPITDQLRAMNKAAHQESTEHVLSGGVVVSAIFFILSAN 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 ILSSPSKRGQKGTLIGYSPEGTPLYNFMGDAFQHSSQSIPRFIKESLKQILEESDSRQIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ILSSPSKRGQKGTLIGYSPEGTPLYNFMGDAFQHSSQSIPRFIKESLKQILEESDSRQIF 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE0 YFLCLNLLFTFVELFYGVLTNSLGLISDGFHMLFDCSALVMGLFAALMSRWKATRIFSYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YFLCLNLLFTFVELFYGVLTNSLGLISDGFHMLFDCSALVMGLFAALMSRWKATRIFSYG 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE0 YGRIEILSGFINGLFLIVIAFFVFMESVARLIDPPELDTHMLTPVSVGGLIVNLIGICAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YGRIEILSGFINGLFLIVIAFFVFMESVARLIDPPELDTHMLTPVSVGGLIVNLIGICAF 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE0 SHAHSHAHGASQGSCHSSDHSHSHHMHGHSDHGHGHSHGSAGGGMNANMRGVFLHVLADT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SHAHSHAHGASQGSCHSSDHSHSHHMHGHSDHGHGHSHGSAGGGMNANMRGVFLHVLADT 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE0 LGSIGVIVSTVLIEQFGWFIADPLCSLFIAILIFLSVVPLIKDACQVLLLRLPPEYEKEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LGSIGVIVSTVLIEQFGWFIADPLCSLFIAILIFLSVVPLIKDACQVLLLRLPPEYEKEL 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE0 HIALEKIQKIEGLISYRDPHFWRHSASIVAGTIHIQVTSDVLEQRIVQQVTGILKDAGVN :::::: ::::::::::: XP_006 HIALEK-------------------------------------------VTGILKDAGVN 670 730 740 750 760 pF1KE0 NLTIQVEKEAYFQHMSGLSTGFHDVLAMTKQMESMKYCKDGTYIM ::::::::::::::::::::::::::::::::::::::::::::: XP_006 NLTIQVEKEAYFQHMSGLSTGFHDVLAMTKQMESMKYCKDGTYIM 680 690 700 710 720 >>XP_016865238 (OMIM: 607819) PREDICTED: zinc transporte (681 aa) initn: 4538 init1: 3970 opt: 3970 Z-score: 4601.3 bits: 862.0 E(85289): 0 Smith-Waterman score: 4339; 89.0% identity (89.0% similar) in 765 aa overlap (1-765:1-681) 10 20 30 40 50 60 pF1KE0 MEEKYGGDVLAGPGGGGGLGPVDVPSARLTKYIVLLCFTKFLKAVGLFESYDLLKAVHIV :::::::::::::::::::::::::::: XP_016 MEEKYGGDVLAGPGGGGGLGPVDVPSAR-------------------------------- 10 20 70 80 90 100 110 120 pF1KE0 QFIFILKLGTAFFMVLFQKPFSSGKTITKHQWIKIFKHAVAGCIISLLWFFGLTLCGPLR ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ---------TAFFMVLFQKPFSSGKTITKHQWIKIFKHAVAGCIISLLWFFGLTLCGPLR 30 40 50 60 70 130 140 150 160 170 180 pF1KE0 TLLLFEHSDIVVISLLSVLFTSSGGGPAKTRGAAFFIIAVICLLLFDNDDLMAKMAEHPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TLLLFEHSDIVVISLLSVLFTSSGGGPAKTRGAAFFIIAVICLLLFDNDDLMAKMAEHPE 80 90 100 110 120 130 190 200 210 220 230 240 pF1KE0 GHHDSALTHMLYTAIAFLGVADHKGGVLLLVLALCCKVGFHTASRKLSVDVGGAKRLQAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GHHDSALTHMLYTAIAFLGVADHKGGVLLLVLALCCKVGFHTASRKLSVDVGGAKRLQAL 140 150 160 170 180 190 250 260 270 280 290 300 pF1KE0 SHLVSVLLLCPWVIVLSVTTESKVESWFSLIMPFATVIFFVMILDFYVDSICSVKMEVSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SHLVSVLLLCPWVIVLSVTTESKVESWFSLIMPFATVIFFVMILDFYVDSICSVKMEVSK 200 210 220 230 240 250 310 320 330 340 350 360 pF1KE0 CARYGSFPIFISALLFGNFWTHPITDQLRAMNKAAHQESTEHVLSGGVVVSAIFFILSAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CARYGSFPIFISALLFGNFWTHPITDQLRAMNKAAHQESTEHVLSGGVVVSAIFFILSAN 260 270 280 290 300 310 370 380 390 400 410 420 pF1KE0 ILSSPSKRGQKGTLIGYSPEGTPLYNFMGDAFQHSSQSIPRFIKESLKQILEESDSRQIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ILSSPSKRGQKGTLIGYSPEGTPLYNFMGDAFQHSSQSIPRFIKESLKQILEESDSRQIF 320 330 340 350 360 370 430 440 450 460 470 480 pF1KE0 YFLCLNLLFTFVELFYGVLTNSLGLISDGFHMLFDCSALVMGLFAALMSRWKATRIFSYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YFLCLNLLFTFVELFYGVLTNSLGLISDGFHMLFDCSALVMGLFAALMSRWKATRIFSYG 380 390 400 410 420 430 490 500 510 520 530 540 pF1KE0 YGRIEILSGFINGLFLIVIAFFVFMESVARLIDPPELDTHMLTPVSVGGLIVNLIGICAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YGRIEILSGFINGLFLIVIAFFVFMESVARLIDPPELDTHMLTPVSVGGLIVNLIGICAF 440 450 460 470 480 490 550 560 570 580 590 600 pF1KE0 SHAHSHAHGASQGSCHSSDHSHSHHMHGHSDHGHGHSHGSAGGGMNANMRGVFLHVLADT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SHAHSHAHGASQGSCHSSDHSHSHHMHGHSDHGHGHSHGSAGGGMNANMRGVFLHVLADT 500 510 520 530 540 550 610 620 630 640 650 660 pF1KE0 LGSIGVIVSTVLIEQFGWFIADPLCSLFIAILIFLSVVPLIKDACQVLLLRLPPEYEKEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LGSIGVIVSTVLIEQFGWFIADPLCSLFIAILIFLSVVPLIKDACQVLLLRLPPEYEKEL 560 570 580 590 600 610 670 680 690 700 710 720 pF1KE0 HIALEKIQKIEGLISYRDPHFWRHSASIVAGTIHIQVTSDVLEQRIVQQVTGILKDAGVN :::::: ::::::::::: XP_016 HIALEK-------------------------------------------VTGILKDAGVN 620 630 730 740 750 760 pF1KE0 NLTIQVEKEAYFQHMSGLSTGFHDVLAMTKQMESMKYCKDGTYIM ::::::::::::::::::::::::::::::::::::::::::::: XP_016 NLTIQVEKEAYFQHMSGLSTGFHDVLAMTKQMESMKYCKDGTYIM 640 650 660 670 680 >>XP_016855890 (OMIM: 611149) PREDICTED: zinc transporte (289 aa) initn: 904 init1: 514 opt: 642 Z-score: 746.9 bits: 147.5 E(85289): 7.3e-35 Smith-Waterman score: 835; 49.0% identity (74.3% similar) in 261 aa overlap (407-640:26-285) 380 390 400 410 420 430 pF1KE0 YSPEGTPLYNFMGDAFQHSSQSIPRFIKESLKQILEESDSRQIFYFLCLNLLFTFVELFY ...:: .. ::..:.:::::: :.::::.: XP_016 MLPLSIKDDEYKPPKFNLFGKISGWFRSILSDKTSRNLFFFLCLNLSFAFVELLY 10 20 30 40 50 440 450 460 470 480 490 pF1KE0 GVLTNSLGLISDGFHMLFDCSALVMGLFAALMSRWKATRIFSYGYGRIEILSGFINGLFL :. .: ::::::.:::.:: .:.. :: :...:.:. . ::::: : :.:.::.::::: XP_016 GIWSNCLGLISDSFHMFFDSTAILAGLAASVISKWRDNDAFSYGYVRAEVLAGFVNGLFL 60 70 80 90 100 110 500 510 520 530 540 550 pF1KE0 IVIAFFVFMESVARLIDPPELDTHMLTPVSVGGLIVNLIGICAFSHA-HSHAHGASQGSC : :::.: :.: : . ::.. . : ::. :..:::::: .:.:. :.:.::...: XP_016 IFTAFFIFSEGVERALAPPDVHHERLLLVSILGFVVNLIGIFVFKHGGHGHSHGSGHGHS 120 130 140 150 160 170 560 570 580 pF1KE0 HS------------SDHSHSH-------HMHGHSDHGHGHSHGSAGGGMNAN-------M :: :: ::: : : :. ::::: :. : ... . . XP_016 HSLFNGALDQAHGHVDHCHSHEVKHGAAHSHDHA-HGHGHFHSHDGPSLKETTGPSRQIL 180 190 200 210 220 230 590 600 610 620 630 640 pF1KE0 RGVFLHVLADTLGSIGVIVSTVLIEQFGWFIADPLCSLFIAILIFLSVVPLIKDACQVLL .:::::.:::::::::::.:......:: .::::.::..::::: .::.:. XP_016 QGVFLHILADTLGSIGVIASAIMMQNFGLMIADPICSILIAILIVVSVIPFPQKF 240 250 260 270 280 650 660 670 680 690 700 pF1KE0 LRLPPEYEKELHIALEKIQKIEGLISYRDPHFWRHSASIVAGTIHIQVTSDVLEQRIVQQ >>NP_001138356 (OMIM: 611149) zinc transporter 7 [Homo s (376 aa) initn: 1103 init1: 510 opt: 642 Z-score: 745.3 bits: 147.6 E(85289): 9e-35 Smith-Waterman score: 1019; 44.0% identity (73.0% similar) in 348 aa overlap (407-727:26-372) 380 390 400 410 420 430 pF1KE0 YSPEGTPLYNFMGDAFQHSSQSIPRFIKESLKQILEESDSRQIFYFLCLNLLFTFVELFY ...:: .. ::..:.:::::: :.::::.: NP_001 MLPLSIKDDEYKPPKFNLFGKISGWFRSILSDKTSRNLFFFLCLNLSFAFVELLY 10 20 30 40 50 440 450 460 470 480 490 pF1KE0 GVLTNSLGLISDGFHMLFDCSALVMGLFAALMSRWKATRIFSYGYGRIEILSGFINGLFL :. .: ::::::.:::.:: .:.. :: :...:.:. . ::::: : :.:.::.::::: NP_001 GIWSNCLGLISDSFHMFFDSTAILAGLAASVISKWRDNDAFSYGYVRAEVLAGFVNGLFL 60 70 80 90 100 110 500 510 520 530 540 550 pF1KE0 IVIAFFVFMESVARLIDPPELDTHMLTPVSVGGLIVNLIGICAFSHA-HSHAHGASQGSC : :::.: :.: : . ::.. . : ::. :..:::::: .:.:. :.:.::...: NP_001 IFTAFFIFSEGVERALAPPDVHHERLLLVSILGFVVNLIGIFVFKHGGHGHSHGSGHGHS 120 130 140 150 160 170 560 570 580 pF1KE0 HS------------SDHSHSH-------HMHGHSDHGHGHSHGSAGGGMNAN-------M :: :: ::: : : :. ::::: :. : ... . . NP_001 HSLFNGALDQAHGHVDHCHSHEVKHGAAHSHDHA-HGHGHFHSHDGPSLKETTGPSRQIL 180 190 200 210 220 230 590 600 610 620 630 640 pF1KE0 RGVFLHVLADTLGSIGVIVSTVLIEQFGWFIADPLCSLFIAILIFLSVVPLIKDACQVLL .:::::.:::::::::::.:......:: .::::.::..::::: .::.::.... .:. NP_001 QGVFLHILADTLGSIGVIASAIMMQNFGLMIADPICSILIAILIVVSVIPLLRESVGILM 240 250 260 270 280 290 650 660 670 680 690 700 pF1KE0 LRLPPEYEKELHIALEKIQKIEGLISYRDPHFWRHSASIVAGTIHIQVTSDVLEQRIVQQ : :: :. : ...:...:. : .. ::: ... .::... :. :. . :..: NP_001 QRTPPLLENSLPQCYQRVQQLQGVYSLQEQHFWTLCSDVYVGTLKLIVAPDADARWILSQ 300 310 320 330 340 350 710 720 730 740 750 760 pF1KE0 VTGILKDAGVNNLTIQVEKEAYFQHMSGLSTGFHDVLAMTKQMESMKYCKDGTYIM . .:. .::: .: .:.. NP_001 THNIFTQAGVRQLYVQIDFAAM 360 370 >>NP_598003 (OMIM: 611149) zinc transporter 7 [Homo sapi (376 aa) initn: 1103 init1: 510 opt: 642 Z-score: 745.3 bits: 147.6 E(85289): 9e-35 Smith-Waterman score: 1019; 44.0% identity (73.0% similar) in 348 aa overlap (407-727:26-372) 380 390 400 410 420 430 pF1KE0 YSPEGTPLYNFMGDAFQHSSQSIPRFIKESLKQILEESDSRQIFYFLCLNLLFTFVELFY ...:: .. ::..:.:::::: :.::::.: NP_598 MLPLSIKDDEYKPPKFNLFGKISGWFRSILSDKTSRNLFFFLCLNLSFAFVELLY 10 20 30 40 50 440 450 460 470 480 490 pF1KE0 GVLTNSLGLISDGFHMLFDCSALVMGLFAALMSRWKATRIFSYGYGRIEILSGFINGLFL :. .: ::::::.:::.:: .:.. :: :...:.:. . ::::: : :.:.::.::::: NP_598 GIWSNCLGLISDSFHMFFDSTAILAGLAASVISKWRDNDAFSYGYVRAEVLAGFVNGLFL 60 70 80 90 100 110 500 510 520 530 540 550 pF1KE0 IVIAFFVFMESVARLIDPPELDTHMLTPVSVGGLIVNLIGICAFSHA-HSHAHGASQGSC : :::.: :.: : . ::.. . : ::. :..:::::: .:.:. :.:.::...: NP_598 IFTAFFIFSEGVERALAPPDVHHERLLLVSILGFVVNLIGIFVFKHGGHGHSHGSGHGHS 120 130 140 150 160 170 560 570 580 pF1KE0 HS------------SDHSHSH-------HMHGHSDHGHGHSHGSAGGGMNAN-------M :: :: ::: : : :. ::::: :. : ... . . NP_598 HSLFNGALDQAHGHVDHCHSHEVKHGAAHSHDHA-HGHGHFHSHDGPSLKETTGPSRQIL 180 190 200 210 220 230 590 600 610 620 630 640 pF1KE0 RGVFLHVLADTLGSIGVIVSTVLIEQFGWFIADPLCSLFIAILIFLSVVPLIKDACQVLL .:::::.:::::::::::.:......:: .::::.::..::::: .::.::.... .:. NP_598 QGVFLHILADTLGSIGVIASAIMMQNFGLMIADPICSILIAILIVVSVIPLLRESVGILM 240 250 260 270 280 290 650 660 670 680 690 700 pF1KE0 LRLPPEYEKELHIALEKIQKIEGLISYRDPHFWRHSASIVAGTIHIQVTSDVLEQRIVQQ : :: :. : ...:...:. : .. ::: ... .::... :. :. . :..: NP_598 QRTPPLLENSLPQCYQRVQQLQGVYSLQEQHFWTLCSDVYVGTLKLIVAPDADARWILSQ 300 310 320 330 340 350 710 720 730 740 750 760 pF1KE0 VTGILKDAGVNNLTIQVEKEAYFQHMSGLSTGFHDVLAMTKQMESMKYCKDGTYIM . .:. .::: .: .:.. NP_598 THNIFTQAGVRQLYVQIDFAAM 360 370 >>XP_016855889 (OMIM: 611149) PREDICTED: zinc transporte (376 aa) initn: 1103 init1: 510 opt: 642 Z-score: 745.3 bits: 147.6 E(85289): 9e-35 Smith-Waterman score: 1019; 44.0% identity (73.0% similar) in 348 aa overlap (407-727:26-372) 380 390 400 410 420 430 pF1KE0 YSPEGTPLYNFMGDAFQHSSQSIPRFIKESLKQILEESDSRQIFYFLCLNLLFTFVELFY ...:: .. ::..:.:::::: :.::::.: XP_016 MLPLSIKDDEYKPPKFNLFGKISGWFRSILSDKTSRNLFFFLCLNLSFAFVELLY 10 20 30 40 50 440 450 460 470 480 490 pF1KE0 GVLTNSLGLISDGFHMLFDCSALVMGLFAALMSRWKATRIFSYGYGRIEILSGFINGLFL :. .: ::::::.:::.:: .:.. :: :...:.:. . ::::: : :.:.::.::::: XP_016 GIWSNCLGLISDSFHMFFDSTAILAGLAASVISKWRDNDAFSYGYVRAEVLAGFVNGLFL 60 70 80 90 100 110 500 510 520 530 540 550 pF1KE0 IVIAFFVFMESVARLIDPPELDTHMLTPVSVGGLIVNLIGICAFSHA-HSHAHGASQGSC : :::.: :.: : . ::.. . : ::. :..:::::: .:.:. :.:.::...: XP_016 IFTAFFIFSEGVERALAPPDVHHERLLLVSILGFVVNLIGIFVFKHGGHGHSHGSGHGHS 120 130 140 150 160 170 560 570 580 pF1KE0 HS------------SDHSHSH-------HMHGHSDHGHGHSHGSAGGGMNAN-------M :: :: ::: : : :. ::::: :. : ... . . XP_016 HSLFNGALDQAHGHVDHCHSHEVKHGAAHSHDHA-HGHGHFHSHDGPSLKETTGPSRQIL 180 190 200 210 220 230 590 600 610 620 630 640 pF1KE0 RGVFLHVLADTLGSIGVIVSTVLIEQFGWFIADPLCSLFIAILIFLSVVPLIKDACQVLL .:::::.:::::::::::.:......:: .::::.::..::::: .::.::.... .:. XP_016 QGVFLHILADTLGSIGVIASAIMMQNFGLMIADPICSILIAILIVVSVIPLLRESVGILM 240 250 260 270 280 290 650 660 670 680 690 700 pF1KE0 LRLPPEYEKELHIALEKIQKIEGLISYRDPHFWRHSASIVAGTIHIQVTSDVLEQRIVQQ : :: :. : ...:...:. : .. ::: ... .::... :. :. . :..: XP_016 QRTPPLLENSLPQCYQRVQQLQGVYSLQEQHFWTLCSDVYVGTLKLIVAPDADARWILSQ 300 310 320 330 340 350 710 720 730 740 750 760 pF1KE0 VTGILKDAGVNNLTIQVEKEAYFQHMSGLSTGFHDVLAMTKQMESMKYCKDGTYIM . .:. .::: .: .:.. XP_016 THNIFTQAGVRQLYVQIDFAAM 360 370 >>NP_076960 (OMIM: 607819) zinc transporter 5 isoform 2 (118 aa) initn: 618 init1: 600 opt: 602 Z-score: 706.0 bits: 138.7 E(85289): 1.4e-32 Smith-Waterman score: 602; 95.9% identity (96.9% similar) in 97 aa overlap (1-97:1-97) 10 20 30 40 50 60 pF1KE0 MEEKYGGDVLAGPGGGGGLGPVDVPSARLTKYIVLLCFTKFLKAVGLFESYDLLKAVHIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_076 MEEKYGGDVLAGPGGGGGLGPVDVPSARLTKYIVLLCFTKFLKAVGLFESYDLLKAVHIV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 QFIFILKLGTAFFMVLFQKPFSSGKTITKHQWIKIFKHAVAGCIISLLWFFGLTLCGPLR ::::::::::::::::::::::::::::::: : .: NP_076 QFIFILKLGTAFFMVLFQKPFSSGKTITKHQIIGSLKIPGRKEFKDKKLNDPRKLVGN 70 80 90 100 110 130 140 150 160 170 180 pF1KE0 TLLLFEHSDIVVISLLSVLFTSSGGGPAKTRGAAFFIIAVICLLLFDNDDLMAKMAEHPE >>XP_011539081 (OMIM: 611149) PREDICTED: zinc transporte (306 aa) initn: 906 init1: 445 opt: 516 Z-score: 600.4 bits: 120.5 E(85289): 1.1e-26 Smith-Waterman score: 826; 41.6% identity (70.6% similar) in 303 aa overlap (452-727:1-302) 430 440 450 460 470 480 pF1KE0 FLCLNLLFTFVELFYGVLTNSLGLISDGFHMLFDCSALVMGLFAALMSRWKATRIFSYGY :.:: .:.. :: :...:.:. . ::::: XP_011 MFFDSTAILAGLAASVISKWRDNDAFSYGY 10 20 30 490 500 510 520 530 540 pF1KE0 GRIEILSGFINGLFLIVIAFFVFMESVARLIDPPELDTHMLTPVSVGGLIVNLIGICAFS : :.:.::.:::::: :::.: :.: : . ::.. . : ::. :..:::::: .:. XP_011 VRAEVLAGFVNGLFLIFTAFFIFSEGVERALAPPDVHHERLLLVSILGFVVNLIGIFVFK 40 50 60 70 80 90 550 560 570 580 pF1KE0 HA-HSHAHGASQGSCHS------------SDHSHSH-------HMHGHSDHGHGHSHGSA :. :.:.::...: :: :: ::: : : :. ::::: :. XP_011 HGGHGHSHGSGHGHSHSLFNGALDQAHGHVDHCHSHEVKHGAAHSHDHA-HGHGHFHSHD 100 110 120 130 140 590 600 610 620 630 pF1KE0 GGGMNAN-------MRGVFLHVLADTLGSIGVIVSTVLIEQFGWFIADPLCSLFIAILIF : ... . ..:::::.:::::::::::.:......:: .::::.::..::::: XP_011 GPSLKETTGPSRQILQGVFLHILADTLGSIGVIASAIMMQNFGLMIADPICSILIAILIV 150 160 170 180 190 200 640 650 660 670 680 690 pF1KE0 LSVVPLIKDACQVLLLRLPPEYEKELHIALEKIQKIEGLISYRDPHFWRHSASIVAGTIH .::.::.... .:. : :: :. : ...:...:. : .. ::: ... .::.. XP_011 VSVIPLLRESVGILMQRTPPLLENSLPQCYQRVQQLQGVYSLQEQHFWTLCSDVYVGTLK 210 220 230 240 250 260 700 710 720 730 740 750 pF1KE0 IQVTSDVLEQRIVQQVTGILKDAGVNNLTIQVEKEAYFQHMSGLSTGFHDVLAMTKQMES . :. :. . :..:. .:. .::: .: .:.. XP_011 LIVAPDADARWILSQTHNIFTQAGVRQLYVQIDFAAM 270 280 290 300 760 pF1KE0 MKYCKDGTYIM 765 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 13:00:06 2016 done: Thu Nov 3 13:00:08 2016 Total Scan time: 10.980 Total Display time: 0.120 Function used was FASTA [36.3.4 Apr, 2011]