FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0406, 341 aa 1>>>pF1KE0406 341 - 341 aa - 341 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.7355+/-0.000913; mu= 13.2420+/- 0.055 mean_var=60.6715+/-11.956, 0's: 0 Z-trim(104.7): 28 B-trim: 0 in 0/48 Lambda= 0.164658 statistics sampled from 8008 (8018) to 8008 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.62), E-opt: 0.2 (0.246), width: 16 Scan time: 2.540 The best scores are: opt bits E(32554) CCDS82795.1 PDHB gene_id:5162|Hs108|chr3 ( 341) 2277 549.5 1.5e-156 CCDS2890.1 PDHB gene_id:5162|Hs108|chr3 ( 359) 2200 531.2 4.9e-151 CCDS54602.1 PDHB gene_id:5162|Hs108|chr3 ( 341) 1434 349.2 2.8e-96 CCDS4994.1 BCKDHB gene_id:594|Hs108|chr6 ( 392) 630 158.3 1e-38 >>CCDS82795.1 PDHB gene_id:5162|Hs108|chr3 (341 aa) initn: 2277 init1: 2277 opt: 2277 Z-score: 2924.3 bits: 549.5 E(32554): 1.5e-156 Smith-Waterman score: 2277; 100.0% identity (100.0% similar) in 341 aa overlap (1-341:1-341) 10 20 30 40 50 60 pF1KE0 MAAVSGLVRRPLREVTVRDAINQGMDEELERDEKVFLLGEEVAQYDGAYKVSRGLWKKYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 MAAVSGLVRRPLREVTVRDAINQGMDEELERDEKVFLLGEEVAQYDGAYKVSRGLWKKYG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 DKRIIDTPISEMGFAGIAVGAAMAGLRPICEFMTFNFSMQAIDQVINSAAKTYYMSGGLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 DKRIIDTPISEMGFAGIAVGAAMAGLRPICEFMTFNFSMQAIDQVINSAAKTYYMSGGLQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 PVPIVFRGPNGASAGVAAQHSQCFAAWYGHCPGLKVVSPWNSEDAKGLIKSAIRDNNPVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 PVPIVFRGPNGASAGVAAQHSQCFAAWYGHCPGLKVVSPWNSEDAKGLIKSAIRDNNPVV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 VLENELMYGVPFEFPPEAQSKDFLIPIGKAKIERQGTHITVVSHSRPVGHCLEAAAVLSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 VLENELMYGVPFEFPPEAQSKDFLIPIGKAKIERQGTHITVVSHSRPVGHCLEAAAVLSK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 EGVECEVINMRTIRPMDMETIEASVMKTNHLVTVEGGWPQFGVGAEICARIMEGPAFNFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 EGVECEVINMRTIRPMDMETIEASVMKTNHLVTVEGGWPQFGVGAEICARIMEGPAFNFL 250 260 270 280 290 300 310 320 330 340 pF1KE0 DAPAVRVTGADVPMPYAKILEDNSIPQVKDIIFAIKKTLNI ::::::::::::::::::::::::::::::::::::::::: CCDS82 DAPAVRVTGADVPMPYAKILEDNSIPQVKDIIFAIKKTLNI 310 320 330 340 >>CCDS2890.1 PDHB gene_id:5162|Hs108|chr3 (359 aa) initn: 2192 init1: 2192 opt: 2200 Z-score: 2825.0 bits: 531.2 E(32554): 4.9e-151 Smith-Waterman score: 2231; 95.0% identity (95.0% similar) in 359 aa overlap (1-341:1-359) 10 20 30 40 pF1KE0 MAAVSGLVRRPLREV------------------TVRDAINQGMDEELERDEKVFLLGEEV ::::::::::::::: ::::::::::::::::::::::::::: CCDS28 MAAVSGLVRRPLREVSGLLKRRFHWTAPAALQVTVRDAINQGMDEELERDEKVFLLGEEV 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE0 AQYDGAYKVSRGLWKKYGDKRIIDTPISEMGFAGIAVGAAMAGLRPICEFMTFNFSMQAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS28 AQYDGAYKVSRGLWKKYGDKRIIDTPISEMGFAGIAVGAAMAGLRPICEFMTFNFSMQAI 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE0 DQVINSAAKTYYMSGGLQPVPIVFRGPNGASAGVAAQHSQCFAAWYGHCPGLKVVSPWNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS28 DQVINSAAKTYYMSGGLQPVPIVFRGPNGASAGVAAQHSQCFAAWYGHCPGLKVVSPWNS 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE0 EDAKGLIKSAIRDNNPVVVLENELMYGVPFEFPPEAQSKDFLIPIGKAKIERQGTHITVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS28 EDAKGLIKSAIRDNNPVVVLENELMYGVPFEFPPEAQSKDFLIPIGKAKIERQGTHITVV 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE0 SHSRPVGHCLEAAAVLSKEGVECEVINMRTIRPMDMETIEASVMKTNHLVTVEGGWPQFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS28 SHSRPVGHCLEAAAVLSKEGVECEVINMRTIRPMDMETIEASVMKTNHLVTVEGGWPQFG 250 260 270 280 290 300 290 300 310 320 330 340 pF1KE0 VGAEICARIMEGPAFNFLDAPAVRVTGADVPMPYAKILEDNSIPQVKDIIFAIKKTLNI ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS28 VGAEICARIMEGPAFNFLDAPAVRVTGADVPMPYAKILEDNSIPQVKDIIFAIKKTLNI 310 320 330 340 350 >>CCDS54602.1 PDHB gene_id:5162|Hs108|chr3 (341 aa) initn: 1419 init1: 1399 opt: 1434 Z-score: 1842.0 bits: 349.2 E(32554): 2.8e-96 Smith-Waterman score: 2059; 90.0% identity (90.0% similar) in 359 aa overlap (1-341:1-341) 10 20 30 40 pF1KE0 MAAVSGLVRRPLREV------------------TVRDAINQGMDEELERDEKVFLLGEEV ::::::::::::::: ::::::::::::::::::::::::::: CCDS54 MAAVSGLVRRPLREVSGLLKRRFHWTAPAALQVTVRDAINQGMDEELERDEKVFLLGEEV 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE0 AQYDGAYKVSRGLWKKYGDKRIIDTPISEMGFAGIAVGAAMAGLRPICEFMTFNFSMQAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS54 AQYDGAYKVSRGLWKKYGDKRIIDTPISEMGFAGIAVGAAMAGLRPICEFMTFNFSMQAI 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE0 DQVINSAAKTYYMSGGLQPVPIVFRGPNGASAGVAAQHSQCFAAWYGHCPGLKVVSPWNS ::::::::::::::: ::::::::::::::::::::::::::: CCDS54 DQVINSAAKTYYMSG------------------VAAQHSQCFAAWYGHCPGLKVVSPWNS 130 140 150 160 170 180 190 200 210 220 pF1KE0 EDAKGLIKSAIRDNNPVVVLENELMYGVPFEFPPEAQSKDFLIPIGKAKIERQGTHITVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS54 EDAKGLIKSAIRDNNPVVVLENELMYGVPFEFPPEAQSKDFLIPIGKAKIERQGTHITVV 170 180 190 200 210 220 230 240 250 260 270 280 pF1KE0 SHSRPVGHCLEAAAVLSKEGVECEVINMRTIRPMDMETIEASVMKTNHLVTVEGGWPQFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS54 SHSRPVGHCLEAAAVLSKEGVECEVINMRTIRPMDMETIEASVMKTNHLVTVEGGWPQFG 230 240 250 260 270 280 290 300 310 320 330 340 pF1KE0 VGAEICARIMEGPAFNFLDAPAVRVTGADVPMPYAKILEDNSIPQVKDIIFAIKKTLNI ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS54 VGAEICARIMEGPAFNFLDAPAVRVTGADVPMPYAKILEDNSIPQVKDIIFAIKKTLNI 290 300 310 320 330 340 >>CCDS4994.1 BCKDHB gene_id:594|Hs108|chr6 (392 aa) initn: 464 init1: 178 opt: 630 Z-score: 808.8 bits: 158.3 E(32554): 1e-38 Smith-Waterman score: 630; 34.4% identity (66.8% similar) in 331 aa overlap (13-340:69-391) 10 20 30 40 pF1KE0 MAAVSGLVRRPLREVTVRDAINQGMDEELERDEKVFLLGEEV ..... .......:. : .: . ..::.: CCDS49 AATVEDAAQRRQVAHFTFQPDPEPREYGQTQKMNLFQSVTSALDNSLAKDPTAVIFGEDV 40 50 60 70 80 90 50 60 70 80 90 100 pF1KE0 AQYDGAYKVSRGLWKKYGDKRIIDTPISEMGFAGIAVGAAMAGLRPICEFMTFNFSMQAI : . :... . :: ::: :...::. :.:..:...: :..: : :.. .. . :. CCDS49 A-FGGVFRCTVGLRDKYGKDRVFNTPLCEQGIVGFGIGIAVTGATAIAEIQFADYIFPAF 100 110 120 130 140 150 110 120 130 140 150 160 pF1KE0 DQVINSAAKTYYMSGGLQPV-PIVFRGPNGASAGVAAQHSQCFAAWYGHCPGLKVVSPWN ::..: ::: : :: : ...:.: : . : ::: :...::::.::: : . CCDS49 DQIVNEAAKYRYRSGDLFNCGSLTIRSPWGCVGHGALYHSQSPEAFFAHCPGIKVVIPRS 160 170 180 190 200 210 170 180 190 200 210 220 pF1KE0 SEDAKGLIKSAIRDNNPVVVLENELMYGVPFEFPPEAQSKDFLIPIGKAKIERQGTHITV .::::. : :.:.:: . .: ...: . : :. . . ::...:.. ..:. .:. CCDS49 PFQAKGLLLSCIEDKNPCIFFEPKILYRAAAE---EVPIEPYNIPLSQAEVIQEGSDVTL 220 230 240 250 260 270 230 240 250 260 270 pF1KE0 VSHSRPVGHCLEAAAVLSKE--GVECEVINMRTIRPMDMETIEASVMKTNHLVTVEGGWP :. . : : .. .: ..:: :: ::::..::: : :..:: ::.::..:. . . CCDS49 VAWGTQV-HVIREVASMAKEKLGVSCEVIDLRTIIPWDVDTICKSVIKTGRLLISHEAPL 280 290 300 310 320 330 280 290 300 310 320 330 pF1KE0 QFGVGAEICARIMEGPAFNFLDAPAVRVTGADVPMPYAKILEDNSIPQVKDIIFAIKKTL : ..:: . ..: : :.:: :: : :.:.:. :.: ::. :..: . CCDS49 TGGFASEISSTVQE-ECFLNLEAPISRVCGYDTPFPH--IFEPFYIPDKWKCYDALRKMI 340 350 360 370 380 390 340 pF1KE0 NI : CCDS49 NY 341 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 12:09:16 2016 done: Thu Nov 3 12:09:16 2016 Total Scan time: 2.540 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]