FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0406, 341 aa 1>>>pF1KE0406 341 - 341 aa - 341 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2822+/-0.000397; mu= 16.2118+/- 0.025 mean_var=62.1531+/-12.534, 0's: 0 Z-trim(111.5): 24 B-trim: 439 in 2/48 Lambda= 0.162683 statistics sampled from 20131 (20151) to 20131 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.606), E-opt: 0.2 (0.236), width: 16 Scan time: 7.180 The best scores are: opt bits E(85289) NP_001302465 (OMIM: 179060,614111) pyruvate dehydr ( 341) 2277 543.1 3.2e-154 NP_000916 (OMIM: 179060,614111) pyruvate dehydroge ( 359) 2200 525.1 9.1e-149 NP_001166939 (OMIM: 179060,614111) pyruvate dehydr ( 341) 1434 345.3 1.1e-94 XP_011534328 (OMIM: 248600,248611) PREDICTED: 2-ox ( 322) 629 156.3 8.2e-38 NP_001305904 (OMIM: 248600,248611) 2-oxoisovalerat ( 322) 629 156.3 8.2e-38 NP_000047 (OMIM: 248600,248611) 2-oxoisovalerate d ( 392) 630 156.6 8.2e-38 NP_898871 (OMIM: 248600,248611) 2-oxoisovalerate d ( 392) 630 156.6 8.2e-38 XP_011534325 (OMIM: 248600,248611) PREDICTED: 2-ox ( 359) 561 140.4 5.7e-33 XP_005248813 (OMIM: 248600,248611) PREDICTED: 2-ox ( 360) 560 140.2 6.8e-33 XP_011534326 (OMIM: 248600,248611) PREDICTED: 2-ox ( 353) 559 139.9 7.8e-33 XP_011534327 (OMIM: 248600,248611) PREDICTED: 2-ox ( 350) 557 139.4 1.1e-32 NP_001139406 (OMIM: 300044) transketolase-like pro ( 540) 196 54.8 5e-07 NP_001139405 (OMIM: 300044) transketolase-like pro ( 590) 196 54.8 5.4e-07 NP_036385 (OMIM: 300044) transketolase-like protei ( 596) 196 54.8 5.4e-07 XP_011532357 (OMIM: 606781,617044) PREDICTED: tran ( 457) 147 43.3 0.0013 NP_001055 (OMIM: 606781,617044) transketolase isof ( 623) 147 43.3 0.0016 NP_001128527 (OMIM: 606781,617044) transketolase i ( 623) 147 43.3 0.0016 XP_011532356 (OMIM: 606781,617044) PREDICTED: tran ( 631) 147 43.3 0.0017 NP_001244957 (OMIM: 606781,617044) transketolase i ( 631) 147 43.3 0.0017 >>NP_001302465 (OMIM: 179060,614111) pyruvate dehydrogen (341 aa) initn: 2277 init1: 2277 opt: 2277 Z-score: 2889.8 bits: 543.1 E(85289): 3.2e-154 Smith-Waterman score: 2277; 100.0% identity (100.0% similar) in 341 aa overlap (1-341:1-341) 10 20 30 40 50 60 pF1KE0 MAAVSGLVRRPLREVTVRDAINQGMDEELERDEKVFLLGEEVAQYDGAYKVSRGLWKKYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAAVSGLVRRPLREVTVRDAINQGMDEELERDEKVFLLGEEVAQYDGAYKVSRGLWKKYG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 DKRIIDTPISEMGFAGIAVGAAMAGLRPICEFMTFNFSMQAIDQVINSAAKTYYMSGGLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DKRIIDTPISEMGFAGIAVGAAMAGLRPICEFMTFNFSMQAIDQVINSAAKTYYMSGGLQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 PVPIVFRGPNGASAGVAAQHSQCFAAWYGHCPGLKVVSPWNSEDAKGLIKSAIRDNNPVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PVPIVFRGPNGASAGVAAQHSQCFAAWYGHCPGLKVVSPWNSEDAKGLIKSAIRDNNPVV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 VLENELMYGVPFEFPPEAQSKDFLIPIGKAKIERQGTHITVVSHSRPVGHCLEAAAVLSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VLENELMYGVPFEFPPEAQSKDFLIPIGKAKIERQGTHITVVSHSRPVGHCLEAAAVLSK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 EGVECEVINMRTIRPMDMETIEASVMKTNHLVTVEGGWPQFGVGAEICARIMEGPAFNFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EGVECEVINMRTIRPMDMETIEASVMKTNHLVTVEGGWPQFGVGAEICARIMEGPAFNFL 250 260 270 280 290 300 310 320 330 340 pF1KE0 DAPAVRVTGADVPMPYAKILEDNSIPQVKDIIFAIKKTLNI ::::::::::::::::::::::::::::::::::::::::: NP_001 DAPAVRVTGADVPMPYAKILEDNSIPQVKDIIFAIKKTLNI 310 320 330 340 >>NP_000916 (OMIM: 179060,614111) pyruvate dehydrogenase (359 aa) initn: 2192 init1: 2192 opt: 2200 Z-score: 2791.8 bits: 525.1 E(85289): 9.1e-149 Smith-Waterman score: 2231; 95.0% identity (95.0% similar) in 359 aa overlap (1-341:1-359) 10 20 30 40 pF1KE0 MAAVSGLVRRPLREV------------------TVRDAINQGMDEELERDEKVFLLGEEV ::::::::::::::: ::::::::::::::::::::::::::: NP_000 MAAVSGLVRRPLREVSGLLKRRFHWTAPAALQVTVRDAINQGMDEELERDEKVFLLGEEV 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE0 AQYDGAYKVSRGLWKKYGDKRIIDTPISEMGFAGIAVGAAMAGLRPICEFMTFNFSMQAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 AQYDGAYKVSRGLWKKYGDKRIIDTPISEMGFAGIAVGAAMAGLRPICEFMTFNFSMQAI 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE0 DQVINSAAKTYYMSGGLQPVPIVFRGPNGASAGVAAQHSQCFAAWYGHCPGLKVVSPWNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 DQVINSAAKTYYMSGGLQPVPIVFRGPNGASAGVAAQHSQCFAAWYGHCPGLKVVSPWNS 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE0 EDAKGLIKSAIRDNNPVVVLENELMYGVPFEFPPEAQSKDFLIPIGKAKIERQGTHITVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 EDAKGLIKSAIRDNNPVVVLENELMYGVPFEFPPEAQSKDFLIPIGKAKIERQGTHITVV 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE0 SHSRPVGHCLEAAAVLSKEGVECEVINMRTIRPMDMETIEASVMKTNHLVTVEGGWPQFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 SHSRPVGHCLEAAAVLSKEGVECEVINMRTIRPMDMETIEASVMKTNHLVTVEGGWPQFG 250 260 270 280 290 300 290 300 310 320 330 340 pF1KE0 VGAEICARIMEGPAFNFLDAPAVRVTGADVPMPYAKILEDNSIPQVKDIIFAIKKTLNI ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 VGAEICARIMEGPAFNFLDAPAVRVTGADVPMPYAKILEDNSIPQVKDIIFAIKKTLNI 310 320 330 340 350 >>NP_001166939 (OMIM: 179060,614111) pyruvate dehydrogen (341 aa) initn: 1419 init1: 1399 opt: 1434 Z-score: 1820.5 bits: 345.3 E(85289): 1.1e-94 Smith-Waterman score: 2059; 90.0% identity (90.0% similar) in 359 aa overlap (1-341:1-341) 10 20 30 40 pF1KE0 MAAVSGLVRRPLREV------------------TVRDAINQGMDEELERDEKVFLLGEEV ::::::::::::::: ::::::::::::::::::::::::::: NP_001 MAAVSGLVRRPLREVSGLLKRRFHWTAPAALQVTVRDAINQGMDEELERDEKVFLLGEEV 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE0 AQYDGAYKVSRGLWKKYGDKRIIDTPISEMGFAGIAVGAAMAGLRPICEFMTFNFSMQAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AQYDGAYKVSRGLWKKYGDKRIIDTPISEMGFAGIAVGAAMAGLRPICEFMTFNFSMQAI 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE0 DQVINSAAKTYYMSGGLQPVPIVFRGPNGASAGVAAQHSQCFAAWYGHCPGLKVVSPWNS ::::::::::::::: ::::::::::::::::::::::::::: NP_001 DQVINSAAKTYYMSG------------------VAAQHSQCFAAWYGHCPGLKVVSPWNS 130 140 150 160 170 180 190 200 210 220 pF1KE0 EDAKGLIKSAIRDNNPVVVLENELMYGVPFEFPPEAQSKDFLIPIGKAKIERQGTHITVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EDAKGLIKSAIRDNNPVVVLENELMYGVPFEFPPEAQSKDFLIPIGKAKIERQGTHITVV 170 180 190 200 210 220 230 240 250 260 270 280 pF1KE0 SHSRPVGHCLEAAAVLSKEGVECEVINMRTIRPMDMETIEASVMKTNHLVTVEGGWPQFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SHSRPVGHCLEAAAVLSKEGVECEVINMRTIRPMDMETIEASVMKTNHLVTVEGGWPQFG 230 240 250 260 270 280 290 300 310 320 330 340 pF1KE0 VGAEICARIMEGPAFNFLDAPAVRVTGADVPMPYAKILEDNSIPQVKDIIFAIKKTLNI ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VGAEICARIMEGPAFNFLDAPAVRVTGADVPMPYAKILEDNSIPQVKDIIFAIKKTLNI 290 300 310 320 330 340 >>XP_011534328 (OMIM: 248600,248611) PREDICTED: 2-oxoiso (322 aa) initn: 509 init1: 178 opt: 629 Z-score: 799.8 bits: 156.3 E(85289): 8.2e-38 Smith-Waterman score: 629; 35.2% identity (66.4% similar) in 324 aa overlap (20-340:6-321) 10 20 30 40 50 60 pF1KE0 MAAVSGLVRRPLREVTVRDAINQGMDEELERDEKVFLLGEEVAQYDGAYKVSRGLWKKYG ......:. : .: . ..::.:: . :... . :: ::: XP_011 MNLFQSVTSALDNSLAKDPTAVIFGEDVA-FGGVFRCTVGLRDKYG 10 20 30 40 70 80 90 100 110 120 pF1KE0 DKRIIDTPISEMGFAGIAVGAAMAGLRPICEFMTFNFSMQAIDQVINSAAKTYYMSGGLQ :...::. :.:..:...: :..: : :.. .. . :.::..: ::: : :: : XP_011 KDRVFNTPLCEQGIVGFGIGIAVTGATAIAEIQFADYIFPAFDQIVNEAAKYRYRSGDLF 50 60 70 80 90 100 130 140 150 160 170 pF1KE0 PV-PIVFRGPNGASAGVAAQHSQCFAAWYGHCPGLKVVSPWNSEDAKGLIKSAIRDNNPV ...:.: : . : ::: :...::::.::: : . .::::. : :.:.:: XP_011 NCGSLTIRSPWGCVGHGALYHSQSPEAFFAHCPGIKVVIPRSPFQAKGLLLSCIEDKNPC 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE0 VVLENELMYGVPFEFPPEAQSKDFLIPIGKAKIERQGTHITVVSHSRPVGHCLEAAAVLS . .: ...: . : :. . . ::...:.. ..:. .:.:. . : : .. .: .. XP_011 IFFEPKILYRAAAE---EVPIEPYNIPLSQAEVIQEGSDVTLVAWGTQV-HVIREVASMA 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE0 KE--GVECEVINMRTIRPMDMETIEASVMKTNHLVTVEGGWPQFGVGAEICARIMEGPAF :: :: ::::..::: : :..:: ::.::..:. . . : ..:: . ..: : XP_011 KEKLGVSCEVIDLRTIIPWDVDTICKSVIKTGRLLISHEAPLTGGFASEISSTVQE-ECF 230 240 250 260 270 280 300 310 320 330 340 pF1KE0 NFLDAPAVRVTGADVPMPYAKILEDNSIPQVKDIIFAIKKTLNI :.:: :: : :.:.:. :.: ::. :..: .: XP_011 LNLEAPISRVCGYDTPFPH--IFEPFYIPDKWKCYDALRKMINY 290 300 310 320 >>NP_001305904 (OMIM: 248600,248611) 2-oxoisovalerate de (322 aa) initn: 509 init1: 178 opt: 629 Z-score: 799.8 bits: 156.3 E(85289): 8.2e-38 Smith-Waterman score: 629; 35.2% identity (66.4% similar) in 324 aa overlap (20-340:6-321) 10 20 30 40 50 60 pF1KE0 MAAVSGLVRRPLREVTVRDAINQGMDEELERDEKVFLLGEEVAQYDGAYKVSRGLWKKYG ......:. : .: . ..::.:: . :... . :: ::: NP_001 MNLFQSVTSALDNSLAKDPTAVIFGEDVA-FGGVFRCTVGLRDKYG 10 20 30 40 70 80 90 100 110 120 pF1KE0 DKRIIDTPISEMGFAGIAVGAAMAGLRPICEFMTFNFSMQAIDQVINSAAKTYYMSGGLQ :...::. :.:..:...: :..: : :.. .. . :.::..: ::: : :: : NP_001 KDRVFNTPLCEQGIVGFGIGIAVTGATAIAEIQFADYIFPAFDQIVNEAAKYRYRSGDLF 50 60 70 80 90 100 130 140 150 160 170 pF1KE0 PV-PIVFRGPNGASAGVAAQHSQCFAAWYGHCPGLKVVSPWNSEDAKGLIKSAIRDNNPV ...:.: : . : ::: :...::::.::: : . .::::. : :.:.:: NP_001 NCGSLTIRSPWGCVGHGALYHSQSPEAFFAHCPGIKVVIPRSPFQAKGLLLSCIEDKNPC 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE0 VVLENELMYGVPFEFPPEAQSKDFLIPIGKAKIERQGTHITVVSHSRPVGHCLEAAAVLS . .: ...: . : :. . . ::...:.. ..:. .:.:. . : : .. .: .. NP_001 IFFEPKILYRAAAE---EVPIEPYNIPLSQAEVIQEGSDVTLVAWGTQV-HVIREVASMA 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE0 KE--GVECEVINMRTIRPMDMETIEASVMKTNHLVTVEGGWPQFGVGAEICARIMEGPAF :: :: ::::..::: : :..:: ::.::..:. . . : ..:: . ..: : NP_001 KEKLGVSCEVIDLRTIIPWDVDTICKSVIKTGRLLISHEAPLTGGFASEISSTVQE-ECF 230 240 250 260 270 280 300 310 320 330 340 pF1KE0 NFLDAPAVRVTGADVPMPYAKILEDNSIPQVKDIIFAIKKTLNI :.:: :: : :.:.:. :.: ::. :..: .: NP_001 LNLEAPISRVCGYDTPFPH--IFEPFYIPDKWKCYDALRKMINY 290 300 310 320 >>NP_000047 (OMIM: 248600,248611) 2-oxoisovalerate dehyd (392 aa) initn: 464 init1: 178 opt: 630 Z-score: 799.8 bits: 156.6 E(85289): 8.2e-38 Smith-Waterman score: 630; 34.4% identity (66.8% similar) in 331 aa overlap (13-340:69-391) 10 20 30 40 pF1KE0 MAAVSGLVRRPLREVTVRDAINQGMDEELERDEKVFLLGEEV ..... .......:. : .: . ..::.: NP_000 AATVEDAAQRRQVAHFTFQPDPEPREYGQTQKMNLFQSVTSALDNSLAKDPTAVIFGEDV 40 50 60 70 80 90 50 60 70 80 90 100 pF1KE0 AQYDGAYKVSRGLWKKYGDKRIIDTPISEMGFAGIAVGAAMAGLRPICEFMTFNFSMQAI : . :... . :: ::: :...::. :.:..:...: :..: : :.. .. . :. NP_000 A-FGGVFRCTVGLRDKYGKDRVFNTPLCEQGIVGFGIGIAVTGATAIAEIQFADYIFPAF 100 110 120 130 140 150 110 120 130 140 150 160 pF1KE0 DQVINSAAKTYYMSGGLQPV-PIVFRGPNGASAGVAAQHSQCFAAWYGHCPGLKVVSPWN ::..: ::: : :: : ...:.: : . : ::: :...::::.::: : . NP_000 DQIVNEAAKYRYRSGDLFNCGSLTIRSPWGCVGHGALYHSQSPEAFFAHCPGIKVVIPRS 160 170 180 190 200 210 170 180 190 200 210 220 pF1KE0 SEDAKGLIKSAIRDNNPVVVLENELMYGVPFEFPPEAQSKDFLIPIGKAKIERQGTHITV .::::. : :.:.:: . .: ...: . : :. . . ::...:.. ..:. .:. NP_000 PFQAKGLLLSCIEDKNPCIFFEPKILYRAAAE---EVPIEPYNIPLSQAEVIQEGSDVTL 220 230 240 250 260 270 230 240 250 260 270 pF1KE0 VSHSRPVGHCLEAAAVLSKE--GVECEVINMRTIRPMDMETIEASVMKTNHLVTVEGGWP :. . : : .. .: ..:: :: ::::..::: : :..:: ::.::..:. . . NP_000 VAWGTQV-HVIREVASMAKEKLGVSCEVIDLRTIIPWDVDTICKSVIKTGRLLISHEAPL 280 290 300 310 320 330 280 290 300 310 320 330 pF1KE0 QFGVGAEICARIMEGPAFNFLDAPAVRVTGADVPMPYAKILEDNSIPQVKDIIFAIKKTL : ..:: . ..: : :.:: :: : :.:.:. :.: ::. :..: . NP_000 TGGFASEISSTVQE-ECFLNLEAPISRVCGYDTPFPH--IFEPFYIPDKWKCYDALRKMI 340 350 360 370 380 390 340 pF1KE0 NI : NP_000 NY >>NP_898871 (OMIM: 248600,248611) 2-oxoisovalerate dehyd (392 aa) initn: 464 init1: 178 opt: 630 Z-score: 799.8 bits: 156.6 E(85289): 8.2e-38 Smith-Waterman score: 630; 34.4% identity (66.8% similar) in 331 aa overlap (13-340:69-391) 10 20 30 40 pF1KE0 MAAVSGLVRRPLREVTVRDAINQGMDEELERDEKVFLLGEEV ..... .......:. : .: . ..::.: NP_898 AATVEDAAQRRQVAHFTFQPDPEPREYGQTQKMNLFQSVTSALDNSLAKDPTAVIFGEDV 40 50 60 70 80 90 50 60 70 80 90 100 pF1KE0 AQYDGAYKVSRGLWKKYGDKRIIDTPISEMGFAGIAVGAAMAGLRPICEFMTFNFSMQAI : . :... . :: ::: :...::. :.:..:...: :..: : :.. .. . :. NP_898 A-FGGVFRCTVGLRDKYGKDRVFNTPLCEQGIVGFGIGIAVTGATAIAEIQFADYIFPAF 100 110 120 130 140 150 110 120 130 140 150 160 pF1KE0 DQVINSAAKTYYMSGGLQPV-PIVFRGPNGASAGVAAQHSQCFAAWYGHCPGLKVVSPWN ::..: ::: : :: : ...:.: : . : ::: :...::::.::: : . NP_898 DQIVNEAAKYRYRSGDLFNCGSLTIRSPWGCVGHGALYHSQSPEAFFAHCPGIKVVIPRS 160 170 180 190 200 210 170 180 190 200 210 220 pF1KE0 SEDAKGLIKSAIRDNNPVVVLENELMYGVPFEFPPEAQSKDFLIPIGKAKIERQGTHITV .::::. : :.:.:: . .: ...: . : :. . . ::...:.. ..:. .:. NP_898 PFQAKGLLLSCIEDKNPCIFFEPKILYRAAAE---EVPIEPYNIPLSQAEVIQEGSDVTL 220 230 240 250 260 270 230 240 250 260 270 pF1KE0 VSHSRPVGHCLEAAAVLSKE--GVECEVINMRTIRPMDMETIEASVMKTNHLVTVEGGWP :. . : : .. .: ..:: :: ::::..::: : :..:: ::.::..:. . . NP_898 VAWGTQV-HVIREVASMAKEKLGVSCEVIDLRTIIPWDVDTICKSVIKTGRLLISHEAPL 280 290 300 310 320 330 280 290 300 310 320 330 pF1KE0 QFGVGAEICARIMEGPAFNFLDAPAVRVTGADVPMPYAKILEDNSIPQVKDIIFAIKKTL : ..:: . ..: : :.:: :: : :.:.:. :.: ::. :..: . NP_898 TGGFASEISSTVQE-ECFLNLEAPISRVCGYDTPFPH--IFEPFYIPDKWKCYDALRKMI 340 350 360 370 380 390 340 pF1KE0 NI : NP_898 NY >>XP_011534325 (OMIM: 248600,248611) PREDICTED: 2-oxoiso (359 aa) initn: 464 init1: 178 opt: 561 Z-score: 712.9 bits: 140.4 E(85289): 5.7e-33 Smith-Waterman score: 561; 33.3% identity (67.3% similar) in 294 aa overlap (13-303:69-357) 10 20 30 40 pF1KE0 MAAVSGLVRRPLREVTVRDAINQGMDEELERDEKVFLLGEEV ..... .......:. : .: . ..::.: XP_011 AATVEDAAQRRQVAHFTFQPDPEPREYGQTQKMNLFQSVTSALDNSLAKDPTAVIFGEDV 40 50 60 70 80 90 50 60 70 80 90 100 pF1KE0 AQYDGAYKVSRGLWKKYGDKRIIDTPISEMGFAGIAVGAAMAGLRPICEFMTFNFSMQAI : . :... . :: ::: :...::. :.:..:...: :..: : :.. .. . :. XP_011 A-FGGVFRCTVGLRDKYGKDRVFNTPLCEQGIVGFGIGIAVTGATAIAEIQFADYIFPAF 100 110 120 130 140 150 110 120 130 140 150 160 pF1KE0 DQVINSAAKTYYMSGGLQPV-PIVFRGPNGASAGVAAQHSQCFAAWYGHCPGLKVVSPWN ::..: ::: : :: : ...:.: : . : ::: :...::::.::: : . XP_011 DQIVNEAAKYRYRSGDLFNCGSLTIRSPWGCVGHGALYHSQSPEAFFAHCPGIKVVIPRS 160 170 180 190 200 210 170 180 190 200 210 220 pF1KE0 SEDAKGLIKSAIRDNNPVVVLENELMYGVPFEFPPEAQSKDFLIPIGKAKIERQGTHITV .::::. : :.:.:: . .: ...: . : :. . . ::...:.. ..:. .:. XP_011 PFQAKGLLLSCIEDKNPCIFFEPKILYRAAAE---EVPIEPYNIPLSQAEVIQEGSDVTL 220 230 240 250 260 270 230 240 250 260 270 pF1KE0 VSHSRPVGHCLEAAAVLSKE--GVECEVINMRTIRPMDMETIEASVMKTNHLVTVEGGWP :. . : : .. .: ..:: :: ::::..::: : :..:: ::.::..:. . . XP_011 VAWGTQV-HVIREVASMAKEKLGVSCEVIDLRTIIPWDVDTICKSVIKTGRLLISHEAPL 280 290 300 310 320 330 280 290 300 310 320 330 pF1KE0 QFGVGAEICARIMEGPAFNFLDAPAVRVTGADVPMPYAKILEDNSIPQVKDIIFAIKKTL : ..:: . .. . . : : XP_011 TGGFASEISSTVQMSVIQSVCDLPIL 340 350 >>XP_005248813 (OMIM: 248600,248611) PREDICTED: 2-oxoiso (360 aa) initn: 464 init1: 178 opt: 560 Z-score: 711.6 bits: 140.2 E(85289): 6.8e-33 Smith-Waterman score: 560; 33.9% identity (68.2% similar) in 286 aa overlap (13-295:69-349) 10 20 30 40 pF1KE0 MAAVSGLVRRPLREVTVRDAINQGMDEELERDEKVFLLGEEV ..... .......:. : .: . ..::.: XP_005 AATVEDAAQRRQVAHFTFQPDPEPREYGQTQKMNLFQSVTSALDNSLAKDPTAVIFGEDV 40 50 60 70 80 90 50 60 70 80 90 100 pF1KE0 AQYDGAYKVSRGLWKKYGDKRIIDTPISEMGFAGIAVGAAMAGLRPICEFMTFNFSMQAI : . :... . :: ::: :...::. :.:..:...: :..: : :.. .. . :. XP_005 A-FGGVFRCTVGLRDKYGKDRVFNTPLCEQGIVGFGIGIAVTGATAIAEIQFADYIFPAF 100 110 120 130 140 150 110 120 130 140 150 160 pF1KE0 DQVINSAAKTYYMSGGLQPV-PIVFRGPNGASAGVAAQHSQCFAAWYGHCPGLKVVSPWN ::..: ::: : :: : ...:.: : . : ::: :...::::.::: : . XP_005 DQIVNEAAKYRYRSGDLFNCGSLTIRSPWGCVGHGALYHSQSPEAFFAHCPGIKVVIPRS 160 170 180 190 200 210 170 180 190 200 210 220 pF1KE0 SEDAKGLIKSAIRDNNPVVVLENELMYGVPFEFPPEAQSKDFLIPIGKAKIERQGTHITV .::::. : :.:.:: . .: ...: . : :. . . ::...:.. ..:. .:. XP_005 PFQAKGLLLSCIEDKNPCIFFEPKILYRAAAE---EVPIEPYNIPLSQAEVIQEGSDVTL 220 230 240 250 260 270 230 240 250 260 270 pF1KE0 VSHSRPVGHCLEAAAVLSKE--GVECEVINMRTIRPMDMETIEASVMKTNHLVTVEGGWP :. . : : .. .: ..:: :: ::::..::: : :..:: ::.::..:. . . XP_005 VAWGTQV-HVIREVASMAKEKLGVSCEVIDLRTIIPWDVDTICKSVIKTGRLLISHEAPL 280 290 300 310 320 330 280 290 300 310 320 330 pF1KE0 QFGVGAEICARIMEGPAFNFLDAPAVRVTGADVPMPYAKILEDNSIPQVKDIIFAIKKTL : ..:: . .. : XP_005 TGGFASEISSTVQIYPHERTSVKFSVN 340 350 360 >>XP_011534326 (OMIM: 248600,248611) PREDICTED: 2-oxoiso (353 aa) initn: 464 init1: 178 opt: 559 Z-score: 710.4 bits: 139.9 E(85289): 7.8e-33 Smith-Waterman score: 559; 33.8% identity (68.7% similar) in 284 aa overlap (13-293:69-347) 10 20 30 40 pF1KE0 MAAVSGLVRRPLREVTVRDAINQGMDEELERDEKVFLLGEEV ..... .......:. : .: . ..::.: XP_011 AATVEDAAQRRQVAHFTFQPDPEPREYGQTQKMNLFQSVTSALDNSLAKDPTAVIFGEDV 40 50 60 70 80 90 50 60 70 80 90 100 pF1KE0 AQYDGAYKVSRGLWKKYGDKRIIDTPISEMGFAGIAVGAAMAGLRPICEFMTFNFSMQAI : . :... . :: ::: :...::. :.:..:...: :..: : :.. .. . :. XP_011 A-FGGVFRCTVGLRDKYGKDRVFNTPLCEQGIVGFGIGIAVTGATAIAEIQFADYIFPAF 100 110 120 130 140 150 110 120 130 140 150 160 pF1KE0 DQVINSAAKTYYMSGGLQPV-PIVFRGPNGASAGVAAQHSQCFAAWYGHCPGLKVVSPWN ::..: ::: : :: : ...:.: : . : ::: :...::::.::: : . XP_011 DQIVNEAAKYRYRSGDLFNCGSLTIRSPWGCVGHGALYHSQSPEAFFAHCPGIKVVIPRS 160 170 180 190 200 210 170 180 190 200 210 220 pF1KE0 SEDAKGLIKSAIRDNNPVVVLENELMYGVPFEFPPEAQSKDFLIPIGKAKIERQGTHITV .::::. : :.:.:: . .: ...: . : :. . . ::...:.. ..:. .:. XP_011 PFQAKGLLLSCIEDKNPCIFFEPKILYRAAAE---EVPIEPYNIPLSQAEVIQEGSDVTL 220 230 240 250 260 270 230 240 250 260 270 pF1KE0 VSHSRPVGHCLEAAAVLSKE--GVECEVINMRTIRPMDMETIEASVMKTNHLVTVEGGWP :. . : : .. .: ..:: :: ::::..::: : :..:: ::.::..:. . . XP_011 VAWGTQV-HVIREVASMAKEKLGVSCEVIDLRTIIPWDVDTICKSVIKTGRLLISHEAPL 280 290 300 310 320 330 280 290 300 310 320 330 pF1KE0 QFGVGAEICARIMEGPAFNFLDAPAVRVTGADVPMPYAKILEDNSIPQVKDIIFAIKKTL : ..:: . ... XP_011 TGGFASEISSTVQQLEDTGD 340 350 341 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 12:09:16 2016 done: Thu Nov 3 12:09:17 2016 Total Scan time: 7.180 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]