FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0408, 329 aa 1>>>pF1KE0408 329 - 329 aa - 329 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.5224+/-0.000291; mu= 11.9772+/- 0.019 mean_var=114.2471+/-22.855, 0's: 0 Z-trim(121.2): 6 B-trim: 278 in 1/49 Lambda= 0.119992 statistics sampled from 37454 (37461) to 37454 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.773), E-opt: 0.2 (0.439), width: 16 Scan time: 8.110 The best scores are: opt bits E(85289) NP_001275685 (OMIM: 612766) BRISC and BRCA1-A comp ( 329) 2204 391.7 1.2e-108 NP_054892 (OMIM: 612766) BRISC and BRCA1-A complex ( 329) 2204 391.7 1.2e-108 NP_001028721 (OMIM: 612766) BRISC and BRCA1-A comp ( 329) 2204 391.7 1.2e-108 NP_001275686 (OMIM: 612766) BRISC and BRCA1-A comp ( 254) 953 175.0 1.5e-43 >>NP_001275685 (OMIM: 612766) BRISC and BRCA1-A complex (329 aa) initn: 2204 init1: 2204 opt: 2204 Z-score: 2071.8 bits: 391.7 E(85289): 1.2e-108 Smith-Waterman score: 2204; 100.0% identity (100.0% similar) in 329 aa overlap (1-329:1-329) 10 20 30 40 50 60 pF1KE0 MEVAEPSSPTEEEEEEEEHSAEPRPRTRSNPEGAEDRAVGAQASVGSRSEGEGEAASADD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEVAEPSSPTEEEEEEEEHSAEPRPRTRSNPEGAEDRAVGAQASVGSRSEGEGEAASADD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 GSLNTSGAGPKSWQVPPPAPEVQIRTPRVNCPEKVIICLDLSEEMSLPKLESFNGSKTNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GSLNTSGAGPKSWQVPPPAPEVQIRTPRVNCPEKVIICLDLSEEMSLPKLESFNGSKTNA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 LNVSQKMIEMFVRTKHKIDKSHEFALVVVNDDTAWLSGLTSDPRELCSCLYDLETASCST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LNVSQKMIEMFVRTKHKIDKSHEFALVVVNDDTAWLSGLTSDPRELCSCLYDLETASCST 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 FNLEGLFSLIQQKTELPVTENVQTIPPPYVVRTILVYSRPPCQPQFSLTEPMKKMFQCPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FNLEGLFSLIQQKTELPVTENVQTIPPPYVVRTILVYSRPPCQPQFSLTEPMKKMFQCPY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 FFFDVVYIHNGTEEKEEEMSWKDMFAFMGSLDTKGTSYKYEVALAGPALELHNCMAKLLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FFFDVVYIHNGTEEKEEEMSWKDMFAFMGSLDTKGTSYKYEVALAGPALELHNCMAKLLA 250 260 270 280 290 300 310 320 pF1KE0 HPLQRPCQSHASYSLLEEEDEAIEVEATV ::::::::::::::::::::::::::::: NP_001 HPLQRPCQSHASYSLLEEEDEAIEVEATV 310 320 >>NP_054892 (OMIM: 612766) BRISC and BRCA1-A complex mem (329 aa) initn: 2204 init1: 2204 opt: 2204 Z-score: 2071.8 bits: 391.7 E(85289): 1.2e-108 Smith-Waterman score: 2204; 100.0% identity (100.0% similar) in 329 aa overlap (1-329:1-329) 10 20 30 40 50 60 pF1KE0 MEVAEPSSPTEEEEEEEEHSAEPRPRTRSNPEGAEDRAVGAQASVGSRSEGEGEAASADD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_054 MEVAEPSSPTEEEEEEEEHSAEPRPRTRSNPEGAEDRAVGAQASVGSRSEGEGEAASADD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 GSLNTSGAGPKSWQVPPPAPEVQIRTPRVNCPEKVIICLDLSEEMSLPKLESFNGSKTNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_054 GSLNTSGAGPKSWQVPPPAPEVQIRTPRVNCPEKVIICLDLSEEMSLPKLESFNGSKTNA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 LNVSQKMIEMFVRTKHKIDKSHEFALVVVNDDTAWLSGLTSDPRELCSCLYDLETASCST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_054 LNVSQKMIEMFVRTKHKIDKSHEFALVVVNDDTAWLSGLTSDPRELCSCLYDLETASCST 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 FNLEGLFSLIQQKTELPVTENVQTIPPPYVVRTILVYSRPPCQPQFSLTEPMKKMFQCPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_054 FNLEGLFSLIQQKTELPVTENVQTIPPPYVVRTILVYSRPPCQPQFSLTEPMKKMFQCPY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 FFFDVVYIHNGTEEKEEEMSWKDMFAFMGSLDTKGTSYKYEVALAGPALELHNCMAKLLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_054 FFFDVVYIHNGTEEKEEEMSWKDMFAFMGSLDTKGTSYKYEVALAGPALELHNCMAKLLA 250 260 270 280 290 300 310 320 pF1KE0 HPLQRPCQSHASYSLLEEEDEAIEVEATV ::::::::::::::::::::::::::::: NP_054 HPLQRPCQSHASYSLLEEEDEAIEVEATV 310 320 >>NP_001028721 (OMIM: 612766) BRISC and BRCA1-A complex (329 aa) initn: 2204 init1: 2204 opt: 2204 Z-score: 2071.8 bits: 391.7 E(85289): 1.2e-108 Smith-Waterman score: 2204; 100.0% identity (100.0% similar) in 329 aa overlap (1-329:1-329) 10 20 30 40 50 60 pF1KE0 MEVAEPSSPTEEEEEEEEHSAEPRPRTRSNPEGAEDRAVGAQASVGSRSEGEGEAASADD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEVAEPSSPTEEEEEEEEHSAEPRPRTRSNPEGAEDRAVGAQASVGSRSEGEGEAASADD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 GSLNTSGAGPKSWQVPPPAPEVQIRTPRVNCPEKVIICLDLSEEMSLPKLESFNGSKTNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GSLNTSGAGPKSWQVPPPAPEVQIRTPRVNCPEKVIICLDLSEEMSLPKLESFNGSKTNA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 LNVSQKMIEMFVRTKHKIDKSHEFALVVVNDDTAWLSGLTSDPRELCSCLYDLETASCST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LNVSQKMIEMFVRTKHKIDKSHEFALVVVNDDTAWLSGLTSDPRELCSCLYDLETASCST 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 FNLEGLFSLIQQKTELPVTENVQTIPPPYVVRTILVYSRPPCQPQFSLTEPMKKMFQCPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FNLEGLFSLIQQKTELPVTENVQTIPPPYVVRTILVYSRPPCQPQFSLTEPMKKMFQCPY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 FFFDVVYIHNGTEEKEEEMSWKDMFAFMGSLDTKGTSYKYEVALAGPALELHNCMAKLLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FFFDVVYIHNGTEEKEEEMSWKDMFAFMGSLDTKGTSYKYEVALAGPALELHNCMAKLLA 250 260 270 280 290 300 310 320 pF1KE0 HPLQRPCQSHASYSLLEEEDEAIEVEATV ::::::::::::::::::::::::::::: NP_001 HPLQRPCQSHASYSLLEEEDEAIEVEATV 310 320 >>NP_001275686 (OMIM: 612766) BRISC and BRCA1-A complex (254 aa) initn: 1087 init1: 947 opt: 953 Z-score: 903.0 bits: 175.0 E(85289): 1.5e-43 Smith-Waterman score: 1556; 77.2% identity (77.2% similar) in 329 aa overlap (1-329:1-254) 10 20 30 40 50 60 pF1KE0 MEVAEPSSPTEEEEEEEEHSAEPRPRTRSNPEGAEDRAVGAQASVGSRSEGEGEAASADD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEVAEPSSPTEEEEEEEEHSAEPRPRTRSNPEGAEDRAVGAQASVGSRSEGEGEAASADD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 GSLNTSGAGPKSWQVPPPAPEVQIRTPRVNCPEKVIICLDLSEEMSLPKLESFNGSKTNA ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GSLNTSGAGPKSWQVPPPAPEVQIRTPRVNCPEKVIICLDLSEEMSLPKLESFNG----- 70 80 90 100 110 130 140 150 160 170 180 pF1KE0 LNVSQKMIEMFVRTKHKIDKSHEFALVVVNDDTAWLSGLTSDPRELCSCLYDLETASCST NP_001 ------------------------------------------------------------ 190 200 210 220 230 240 pF1KE0 FNLEGLFSLIQQKTELPVTENVQTIPPPYVVRTILVYSRPPCQPQFSLTEPMKKMFQCPY :::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ----------QQKTELPVTENVQTIPPPYVVRTILVYSRPPCQPQFSLTEPMKKMFQCPY 120 130 140 150 160 250 260 270 280 290 300 pF1KE0 FFFDVVYIHNGTEEKEEEMSWKDMFAFMGSLDTKGTSYKYEVALAGPALELHNCMAKLLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FFFDVVYIHNGTEEKEEEMSWKDMFAFMGSLDTKGTSYKYEVALAGPALELHNCMAKLLA 170 180 190 200 210 220 310 320 pF1KE0 HPLQRPCQSHASYSLLEEEDEAIEVEATV ::::::::::::::::::::::::::::: NP_001 HPLQRPCQSHASYSLLEEEDEAIEVEATV 230 240 250 329 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 11:57:40 2016 done: Thu Nov 3 11:57:41 2016 Total Scan time: 8.110 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]