FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0412, 243 aa 1>>>pF1KE0412 243 - 243 aa - 243 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9536+/-0.000318; mu= 18.0017+/- 0.020 mean_var=81.1648+/-16.636, 0's: 0 Z-trim(118.2): 15 B-trim: 977 in 2/54 Lambda= 0.142361 statistics sampled from 30903 (30918) to 30903 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.723), E-opt: 0.2 (0.363), width: 16 Scan time: 7.100 The best scores are: opt bits E(85289) NP_005077 (OMIM: 601599) sarcospan isoform 1 [Homo ( 243) 1661 350.0 2.2e-96 XP_011519157 (OMIM: 601599) PREDICTED: sarcospan i ( 140) 947 203.1 2.1e-52 XP_011519155 (OMIM: 601599) PREDICTED: sarcospan i ( 140) 947 203.1 2.1e-52 NP_001129295 (OMIM: 601599) sarcospan isoform 2 [H ( 140) 947 203.1 2.1e-52 XP_011519156 (OMIM: 601599) PREDICTED: sarcospan i ( 140) 947 203.1 2.1e-52 XP_005252364 (OMIM: 607710) PREDICTED: protein FAM ( 603) 156 41.3 0.0047 >>NP_005077 (OMIM: 601599) sarcospan isoform 1 [Homo sap (243 aa) initn: 1661 init1: 1661 opt: 1661 Z-score: 1851.4 bits: 350.0 E(85289): 2.2e-96 Smith-Waterman score: 1661; 100.0% identity (100.0% similar) in 243 aa overlap (1-243:1-243) 10 20 30 40 50 60 pF1KE0 MGKNKQPRGQQRQGGPPAADAAGPDDMEPKKGTGAPKECGEEEPRTCCGCRFPLLLALLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MGKNKQPRGQQRQGGPPAADAAGPDDMEPKKGTGAPKECGEEEPRTCCGCRFPLLLALLQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 LALGIAVTVVGFLMASISSSLLVRDTPFWAGIIVCLVAYLGLFMLCVSYQVDERTCIQFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LALGIAVTVVGFLMASISSSLLVRDTPFWAGIIVCLVAYLGLFMLCVSYQVDERTCIQFS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 MKLLYFLLSALGLTVCVLAVAFAAHHYSQLTQFTCETTLDSCQCKLPSSEPLSRTFVYRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MKLLYFLLSALGLTVCVLAVAFAAHHYSQLTQFTCETTLDSCQCKLPSSEPLSRTFVYRD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 VTDCTSVTGTFKLFLLIQMILNLVCGLVCLLACFVMWKHRYQVFYVGVRICSLTASEGPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 VTDCTSVTGTFKLFLLIQMILNLVCGLVCLLACFVMWKHRYQVFYVGVRICSLTASEGPQ 190 200 210 220 230 240 pF1KE0 QKI ::: NP_005 QKI >>XP_011519157 (OMIM: 601599) PREDICTED: sarcospan isofo (140 aa) initn: 947 init1: 947 opt: 947 Z-score: 1061.9 bits: 203.1 E(85289): 2.1e-52 Smith-Waterman score: 947; 100.0% identity (100.0% similar) in 140 aa overlap (104-243:1-140) 80 90 100 110 120 130 pF1KE0 MASISSSLLVRDTPFWAGIIVCLVAYLGLFMLCVSYQVDERTCIQFSMKLLYFLLSALGL :::::::::::::::::::::::::::::: XP_011 MLCVSYQVDERTCIQFSMKLLYFLLSALGL 10 20 30 140 150 160 170 180 190 pF1KE0 TVCVLAVAFAAHHYSQLTQFTCETTLDSCQCKLPSSEPLSRTFVYRDVTDCTSVTGTFKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TVCVLAVAFAAHHYSQLTQFTCETTLDSCQCKLPSSEPLSRTFVYRDVTDCTSVTGTFKL 40 50 60 70 80 90 200 210 220 230 240 pF1KE0 FLLIQMILNLVCGLVCLLACFVMWKHRYQVFYVGVRICSLTASEGPQQKI :::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FLLIQMILNLVCGLVCLLACFVMWKHRYQVFYVGVRICSLTASEGPQQKI 100 110 120 130 140 >>XP_011519155 (OMIM: 601599) PREDICTED: sarcospan isofo (140 aa) initn: 947 init1: 947 opt: 947 Z-score: 1061.9 bits: 203.1 E(85289): 2.1e-52 Smith-Waterman score: 947; 100.0% identity (100.0% similar) in 140 aa overlap (104-243:1-140) 80 90 100 110 120 130 pF1KE0 MASISSSLLVRDTPFWAGIIVCLVAYLGLFMLCVSYQVDERTCIQFSMKLLYFLLSALGL :::::::::::::::::::::::::::::: XP_011 MLCVSYQVDERTCIQFSMKLLYFLLSALGL 10 20 30 140 150 160 170 180 190 pF1KE0 TVCVLAVAFAAHHYSQLTQFTCETTLDSCQCKLPSSEPLSRTFVYRDVTDCTSVTGTFKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TVCVLAVAFAAHHYSQLTQFTCETTLDSCQCKLPSSEPLSRTFVYRDVTDCTSVTGTFKL 40 50 60 70 80 90 200 210 220 230 240 pF1KE0 FLLIQMILNLVCGLVCLLACFVMWKHRYQVFYVGVRICSLTASEGPQQKI :::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FLLIQMILNLVCGLVCLLACFVMWKHRYQVFYVGVRICSLTASEGPQQKI 100 110 120 130 140 >>NP_001129295 (OMIM: 601599) sarcospan isoform 2 [Homo (140 aa) initn: 947 init1: 947 opt: 947 Z-score: 1061.9 bits: 203.1 E(85289): 2.1e-52 Smith-Waterman score: 947; 100.0% identity (100.0% similar) in 140 aa overlap (104-243:1-140) 80 90 100 110 120 130 pF1KE0 MASISSSLLVRDTPFWAGIIVCLVAYLGLFMLCVSYQVDERTCIQFSMKLLYFLLSALGL :::::::::::::::::::::::::::::: NP_001 MLCVSYQVDERTCIQFSMKLLYFLLSALGL 10 20 30 140 150 160 170 180 190 pF1KE0 TVCVLAVAFAAHHYSQLTQFTCETTLDSCQCKLPSSEPLSRTFVYRDVTDCTSVTGTFKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TVCVLAVAFAAHHYSQLTQFTCETTLDSCQCKLPSSEPLSRTFVYRDVTDCTSVTGTFKL 40 50 60 70 80 90 200 210 220 230 240 pF1KE0 FLLIQMILNLVCGLVCLLACFVMWKHRYQVFYVGVRICSLTASEGPQQKI :::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FLLIQMILNLVCGLVCLLACFVMWKHRYQVFYVGVRICSLTASEGPQQKI 100 110 120 130 140 >>XP_011519156 (OMIM: 601599) PREDICTED: sarcospan isofo (140 aa) initn: 947 init1: 947 opt: 947 Z-score: 1061.9 bits: 203.1 E(85289): 2.1e-52 Smith-Waterman score: 947; 100.0% identity (100.0% similar) in 140 aa overlap (104-243:1-140) 80 90 100 110 120 130 pF1KE0 MASISSSLLVRDTPFWAGIIVCLVAYLGLFMLCVSYQVDERTCIQFSMKLLYFLLSALGL :::::::::::::::::::::::::::::: XP_011 MLCVSYQVDERTCIQFSMKLLYFLLSALGL 10 20 30 140 150 160 170 180 190 pF1KE0 TVCVLAVAFAAHHYSQLTQFTCETTLDSCQCKLPSSEPLSRTFVYRDVTDCTSVTGTFKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TVCVLAVAFAAHHYSQLTQFTCETTLDSCQCKLPSSEPLSRTFVYRDVTDCTSVTGTFKL 40 50 60 70 80 90 200 210 220 230 240 pF1KE0 FLLIQMILNLVCGLVCLLACFVMWKHRYQVFYVGVRICSLTASEGPQQKI :::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FLLIQMILNLVCGLVCLLACFVMWKHRYQVFYVGVRICSLTASEGPQQKI 100 110 120 130 140 >>XP_005252364 (OMIM: 607710) PREDICTED: protein FAM189A (603 aa) initn: 105 init1: 63 opt: 156 Z-score: 175.9 bits: 41.3 E(85289): 0.0047 Smith-Waterman score: 156; 26.5% identity (51.7% similar) in 238 aa overlap (6-231:51-272) 10 20 30 pF1KE0 MGKNKQPRGQQRQGGPPAADA-AGPDDMEPKKGTG :: .. : .. :: . :.: . ..... XP_005 PQAGGPGAAAAAAQEPPLPPLRPRWPRGALQPPSRPRCAATAAAGVLAAPPALSSRRAVA 30 40 50 60 70 80 40 50 60 70 80 90 pF1KE0 APKECGEEEPRTCCGCRFPLL-LALLQLALGIAVTVVGFLMASISSSLLVRDT-PFWAGI : . : . ::: :.:::: :: .....: :.::: :... ::::: XP_005 AAAAAA---PGSALLPARPLLSLGLLQLILGCCMVALSFGALSLSSSPQVKNSCPFWAGS 90 100 110 120 130 100 110 120 130 140 pF1KE0 IVCLVAYLGL------FMLCVS-YQVDERTCIQFSMKLLYFLLSALG--LTVCVLAVAFA : : . .:: ..: :. . . .:. ..: :.:. : .. : .. XP_005 SVILSGIIGLTTWKRPMILLVNLFVLLSVVCVL--LNLAGFILGCQGAQFVSSVPRCDLV 140 150 160 170 180 190 150 160 170 180 190 200 pF1KE0 AHHYSQLTQFTCETTLDSCQCKLPSSEPLSRTFVYRDVTDCTSVTGTFKLFLLIQMILNL ... : :: .. .: ..: . : : :..: .: :. :: XP_005 DLGEGKIC-FCCEE-FQPAKCT--DKENALKLF---PVQPCSAVHLLLKKVLFALCALNA 200 210 220 230 240 210 220 230 240 pF1KE0 VCGLVCLLACFVMWKHRYQVFYVGVRICSLTASEGPQQKI . :::.: . :: ... : : XP_005 LTTTVCLVAAAL----RYLQIFATRRSCIDESQISAEEAEDHGRIPDPDDFVPPVPPPSY 250 260 270 280 290 300 243 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 11:42:38 2016 done: Thu Nov 3 11:42:39 2016 Total Scan time: 7.100 Total Display time: -0.030 Function used was FASTA [36.3.4 Apr, 2011]