FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE0433, 414 aa
  1>>>pF1KE0433 414 - 414 aa - 414 aa
Library: human.CCDS.faa
  18511270 residues in 32554 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.4650+/-0.0011; mu= 15.6183+/- 0.066
 mean_var=58.5846+/-11.633, 0's: 0 Z-trim(101.6): 25  B-trim: 0 in 0/49
 Lambda= 0.167565
 statistics sampled from 6580 (6589) to 6580 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.563), E-opt: 0.2 (0.202), width:  16
 Scan time:  2.600

The best scores are:                                      opt bits E(32554)
CCDS2381.1 IDH1 gene_id:3417|Hs108|chr2            ( 414) 2742 671.7 3.6e-193
CCDS10359.1 IDH2 gene_id:3418|Hs108|chr15          ( 452) 1930 475.4 4.8e-134
CCDS76792.1 IDH2 gene_id:3418|Hs108|chr15          ( 400) 1914 471.5 6.3e-133


>>CCDS2381.1 IDH1 gene_id:3417|Hs108|chr2                 (414 aa)
 initn: 2742 init1: 2742 opt: 2742  Z-score: 3581.4  bits: 671.7 E(32554): 3.6e-193
Smith-Waterman score: 2742; 99.5% identity (100.0% similar) in 414 aa overlap (1-414:1-414)

               10        20        30        40        50        60
pF1KE0 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIIPYVELDLHSYDLGIENRDATNDQVTKDA
       :::::::::::::::::::::::::::::::.::::::::::::::::::::::::::::
CCDS23 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE0 AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS23 AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE0 VSGWVEPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM
       :::::.::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS23 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE0 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS23 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE0 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS23 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE0 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS23 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE
              310       320       330       340       350       360

              370       380       390       400       410    
pF1KE0 EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS23 EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL
              370       380       390       400       410    

>>CCDS10359.1 IDH2 gene_id:3418|Hs108|chr15               (452 aa)
 initn: 1908 init1: 1134 opt: 1930  Z-score: 2519.9  bits: 475.4 E(32554): 4.8e-134
Smith-Waterman score: 1930; 70.5% identity (88.4% similar) in 397 aa overlap (10-405:50-445)

                                    10        20        30         
pF1KE0                      MSKKISGGSVVEMQGDEMTRIIWELIKEKLIIPYVELDL
                                     ::::.:::::::::..::::::.:.:...:
CCDS10 AWAPAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQL
      20        30        40        50        60        70         

      40        50        60        70        80        90         
pF1KE0 HSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTI
       . .:::. ::: :.:::: :.: : .:..:.:::::::::: ::::::::.:::::::::
CCDS10 KYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTI
      80        90       100       110       120       130         

     100       110       120       130       140       150         
pF1KE0 RNILGGTVFREAIICKNIPRLVSGWVEPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPS
       ::::::::::: :::::::::: ::..:: :::::.::::.:::::.   :  ....::.
CCDS10 RNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPK
     140       150       160       170       180       190         

     160       170       180       190       200       210         
pF1KE0 DGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKY
       ::.    . :.::  .:::.::::: :.::  :::: ::.:..: ::::.:::::::: :
CCDS10 DGSGVKEWEVYNFP-AGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAY
     200       210        220       230       240       250        

     220       230       240       250       260       270         
pF1KE0 DGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSD
       :::::::::::.::.::..:. .:::::::::::::::..:: :::.:::::::::::::
CCDS10 DGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSD
      260       270       280       290       300       310        

     280       290       300       310       320       330         
pF1KE0 SVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRG
        .:::.::::.::::::::::::.:::::::::::::: .:::. :::::::::::::::
CCDS10 ILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRG
      320       330       340       350       360       370        

     340       350       360       370       380       390         
pF1KE0 LAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSD-YLNTFEFM
       : ::.:::.:..:  ::. ::.: .::.:.: ::::::.::.:: ::. .. .::: .:.
CCDS10 LEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFL
      380       390       400       410       420       430        

      400       410    
pF1KE0 DKLGENLKIKLAQAKL
       : .  ::         
CCDS10 DTIKSNLDRALGRQ  
      440       450    

>>CCDS76792.1 IDH2 gene_id:3418|Hs108|chr15               (400 aa)
 initn: 1892 init1: 1134 opt: 1914  Z-score: 2499.9  bits: 471.5 E(32554): 6.3e-133
Smith-Waterman score: 1914; 70.3% identity (88.3% similar) in 394 aa overlap (13-405:1-393)

               10        20        30        40        50        60
pF1KE0 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIIPYVELDLHSYDLGIENRDATNDQVTKDA
                   :.:::::::::..::::::.:.:...:. .:::. ::: :.:::: :.
CCDS76             MDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDS
                           10        20        30        40        

               70        80        90       100       110       120
pF1KE0 AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL
       : : .:..:.:::::::::: ::::::::.:::::::::::::::::::: :::::::::
CCDS76 ALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRL
       50        60        70        80        90       100        

              130       140       150       160       170       180
pF1KE0 VSGWVEPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM
       : ::..:: :::::.::::.:::::.   :  ....::.::.    . :.::  .:::.:
CCDS76 VPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFP-AGGVGM
      110       120       130       140       150       160        

              190       200       210       220       230       240
pF1KE0 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE
       :::: :.::  :::: ::.:..: ::::.:::::::: ::::::::::::.::.::..:.
CCDS76 GMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFD
       170       180       190       200       210       220       

              250       260       270       280       290       300
pF1KE0 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG
        .:::::::::::::::..:: :::.::::::::::::: .:::.::::.::::::::::
CCDS76 KNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDG
       230       240       250       260       270       280       

              310       320       330       340       350       360
pF1KE0 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE
       ::.:::::::::::::: .:::. :::::::::::::::: ::.:::.:..:  ::. ::
CCDS76 KTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLE
       290       300       310       320       330       340       

              370       380       390        400       410    
pF1KE0 EVSIETIEAGFMTKDLAACIKGLPNVQRSD-YLNTFEFMDKLGENLKIKLAQAKL
       .: .::.:.: ::::::.::.:: ::. .. .::: .:.: .  ::         
CCDS76 KVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQ  
       350       360       370       380       390       400  




414 residues in 1 query   sequences
18511270 residues in 32554 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 09:26:03 2016 done: Thu Nov  3 09:26:03 2016
 Total Scan time:  2.600 Total Display time:  0.000

Function used was FASTA [36.3.4 Apr, 2011]