Result of FASTA (omim) for
pF1KE0433
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0433, 414 aa
1>>>pF1KE0433 414 - 414 aa - 414 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.2726+/-0.000477; mu= 16.8968+/- 0.029
mean_var=62.7008+/-12.489, 0's: 0 Z-trim(108.2): 29 B-trim: 0 in 0/52
Lambda= 0.161971
statistics sampled from 16298 (16311) to 16298 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.548), E-opt: 0.2 (0.191), width: 16
Scan time: 7.380
The best scores are: opt bits E(85289)
NP_001269316 (OMIM: 137800,147700) isocitrate dehy ( 414) 2742 650.0 3.2e-186
NP_005887 (OMIM: 137800,147700) isocitrate dehydro ( 414) 2742 650.0 3.2e-186
NP_001269315 (OMIM: 137800,147700) isocitrate dehy ( 414) 2742 650.0 3.2e-186
NP_002159 (OMIM: 147650,613657) isocitrate dehydro ( 452) 1930 460.2 4.5e-129
NP_001276839 (OMIM: 147650,613657) isocitrate dehy ( 400) 1914 456.5 5.4e-128
NP_001277043 (OMIM: 147650,613657) isocitrate dehy ( 322) 1554 372.3 9.5e-103
>>NP_001269316 (OMIM: 137800,147700) isocitrate dehydrog (414 aa)
initn: 2742 init1: 2742 opt: 2742 Z-score: 3464.3 bits: 650.0 E(85289): 3.2e-186
Smith-Waterman score: 2742; 99.5% identity (100.0% similar) in 414 aa overlap (1-414:1-414)
10 20 30 40 50 60
pF1KE0 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIIPYVELDLHSYDLGIENRDATNDQVTKDA
:::::::::::::::::::::::::::::::.::::::::::::::::::::::::::::
NP_001 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 VSGWVEPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM
:::::.::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE
310 320 330 340 350 360
370 380 390 400 410
pF1KE0 EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL
370 380 390 400 410
>>NP_005887 (OMIM: 137800,147700) isocitrate dehydrogena (414 aa)
initn: 2742 init1: 2742 opt: 2742 Z-score: 3464.3 bits: 650.0 E(85289): 3.2e-186
Smith-Waterman score: 2742; 99.5% identity (100.0% similar) in 414 aa overlap (1-414:1-414)
10 20 30 40 50 60
pF1KE0 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIIPYVELDLHSYDLGIENRDATNDQVTKDA
:::::::::::::::::::::::::::::::.::::::::::::::::::::::::::::
NP_005 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 VSGWVEPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM
:::::.::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE
310 320 330 340 350 360
370 380 390 400 410
pF1KE0 EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL
370 380 390 400 410
>>NP_001269315 (OMIM: 137800,147700) isocitrate dehydrog (414 aa)
initn: 2742 init1: 2742 opt: 2742 Z-score: 3464.3 bits: 650.0 E(85289): 3.2e-186
Smith-Waterman score: 2742; 99.5% identity (100.0% similar) in 414 aa overlap (1-414:1-414)
10 20 30 40 50 60
pF1KE0 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIIPYVELDLHSYDLGIENRDATNDQVTKDA
:::::::::::::::::::::::::::::::.::::::::::::::::::::::::::::
NP_001 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 VSGWVEPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM
:::::.::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE
310 320 330 340 350 360
370 380 390 400 410
pF1KE0 EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL
370 380 390 400 410
>>NP_002159 (OMIM: 147650,613657) isocitrate dehydrogena (452 aa)
initn: 1908 init1: 1134 opt: 1930 Z-score: 2438.2 bits: 460.2 E(85289): 4.5e-129
Smith-Waterman score: 1930; 70.5% identity (88.4% similar) in 397 aa overlap (10-405:50-445)
10 20 30
pF1KE0 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIIPYVELDL
::::.:::::::::..::::::.:.:...:
NP_002 AWAPAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQL
20 30 40 50 60 70
40 50 60 70 80 90
pF1KE0 HSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTI
. .:::. ::: :.:::: :.: : .:..:.:::::::::: ::::::::.:::::::::
NP_002 KYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTI
80 90 100 110 120 130
100 110 120 130 140 150
pF1KE0 RNILGGTVFREAIICKNIPRLVSGWVEPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPS
::::::::::: :::::::::: ::..:: :::::.::::.:::::. : ....::.
NP_002 RNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPK
140 150 160 170 180 190
160 170 180 190 200 210
pF1KE0 DGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKY
::. . :.:: .:::.::::: :.:: :::: ::.:..: ::::.:::::::: :
NP_002 DGSGVKEWEVYNFP-AGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAY
200 210 220 230 240 250
220 230 240 250 260 270
pF1KE0 DGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSD
:::::::::::.::.::..:. .:::::::::::::::..:: :::.:::::::::::::
NP_002 DGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSD
260 270 280 290 300 310
280 290 300 310 320 330
pF1KE0 SVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRG
.:::.::::.::::::::::::.:::::::::::::: .:::. :::::::::::::::
NP_002 ILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRG
320 330 340 350 360 370
340 350 360 370 380 390
pF1KE0 LAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSD-YLNTFEFM
: ::.:::.:..: ::. ::.: .::.:.: ::::::.::.:: ::. .. .::: .:.
NP_002 LEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFL
380 390 400 410 420 430
400 410
pF1KE0 DKLGENLKIKLAQAKL
: . ::
NP_002 DTIKSNLDRALGRQ
440 450
>>NP_001276839 (OMIM: 147650,613657) isocitrate dehydrog (400 aa)
initn: 1892 init1: 1134 opt: 1914 Z-score: 2418.8 bits: 456.5 E(85289): 5.4e-128
Smith-Waterman score: 1914; 70.3% identity (88.3% similar) in 394 aa overlap (13-405:1-393)
10 20 30 40 50 60
pF1KE0 MSKKISGGSVVEMQGDEMTRIIWELIKEKLIIPYVELDLHSYDLGIENRDATNDQVTKDA
:.:::::::::..::::::.:.:...:. .:::. ::: :.:::: :.
NP_001 MDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDS
10 20 30 40
70 80 90 100 110 120
pF1KE0 AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL
: : .:..:.:::::::::: ::::::::.:::::::::::::::::::: :::::::::
NP_001 ALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRL
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE0 VSGWVEPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM
: ::..:: :::::.::::.:::::. : ....::.::. . :.:: .:::.:
NP_001 VPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFP-AGGVGM
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE0 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE
:::: :.:: :::: ::.:..: ::::.:::::::: ::::::::::::.::.::..:.
NP_001 GMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFD
170 180 190 200 210 220
250 260 270 280 290 300
pF1KE0 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG
.:::::::::::::::..:: :::.::::::::::::: .:::.::::.::::::::::
NP_001 KNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDG
230 240 250 260 270 280
310 320 330 340 350 360
pF1KE0 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE
::.:::::::::::::: .:::. :::::::::::::::: ::.:::.:..: ::. ::
NP_001 KTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLE
290 300 310 320 330 340
370 380 390 400 410
pF1KE0 EVSIETIEAGFMTKDLAACIKGLPNVQRSD-YLNTFEFMDKLGENLKIKLAQAKL
.: .::.:.: ::::::.::.:: ::. .. .::: .:.: . ::
NP_001 KVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQ
350 360 370 380 390 400
>>NP_001277043 (OMIM: 147650,613657) isocitrate dehydrog (322 aa)
initn: 1532 init1: 1134 opt: 1554 Z-score: 1965.6 bits: 372.3 E(85289): 9.5e-103
Smith-Waterman score: 1554; 70.9% identity (87.7% similar) in 316 aa overlap (91-405:1-315)
70 80 90 100 110 120
pF1KE0 AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL
:::::::::::::::::::: :::::::::
NP_001 MWKSPNGTIRNILGGTVFREPIICKNIPRL
10 20 30
130 140 150 160 170 180
pF1KE0 VSGWVEPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM
: ::..:: :::::.::::.:::::. : ....::.::. . :.:: .:::.:
NP_001 VPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFP-AGGVGM
40 50 60 70 80
190 200 210 220 230 240
pF1KE0 GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE
:::: :.:: :::: ::.:..: ::::.:::::::: ::::::::::::.::.::..:.
NP_001 GMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFD
90 100 110 120 130 140
250 260 270 280 290 300
pF1KE0 AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG
.:::::::::::::::..:: :::.::::::::::::: .:::.::::.::::::::::
NP_001 KNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDG
150 160 170 180 190 200
310 320 330 340 350 360
pF1KE0 KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE
::.:::::::::::::: .:::. :::::::::::::::: ::.:::.:..: ::. ::
NP_001 KTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLE
210 220 230 240 250 260
370 380 390 400 410
pF1KE0 EVSIETIEAGFMTKDLAACIKGLPNVQRSD-YLNTFEFMDKLGENLKIKLAQAKL
.: .::.:.: ::::::.::.:: ::. .. .::: .:.: . ::
NP_001 KVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQ
270 280 290 300 310 320
414 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 09:26:04 2016 done: Thu Nov 3 09:26:05 2016
Total Scan time: 7.380 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]