FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0443, 322 aa 1>>>pF1KE0443 322 - 322 aa - 322 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.8352+/-0.000382; mu= 12.7987+/- 0.024 mean_var=68.7836+/-14.027, 0's: 0 Z-trim(112.4): 24 B-trim: 39 in 1/51 Lambda= 0.154644 statistics sampled from 21356 (21373) to 21356 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.622), E-opt: 0.2 (0.251), width: 16 Scan time: 7.930 The best scores are: opt bits E(85289) NP_115661 (OMIM: 615105) methylthioribose-1-phosph ( 322) 2069 470.7 1.8e-132 NP_001316501 (OMIM: 615105) methylthioribose-1-pho ( 340) 1090 252.3 1e-66 NP_001026897 (OMIM: 615105) methylthioribose-1-pho ( 369) 1090 252.3 1.1e-66 XP_011526659 (OMIM: 615105) PREDICTED: methylthior ( 213) 781 183.3 3.9e-46 XP_011526658 (OMIM: 615105) PREDICTED: methylthior ( 322) 781 183.4 5.6e-46 NP_001405 (OMIM: 603896,606686) translation initia ( 305) 213 56.6 7.5e-08 XP_011531449 (OMIM: 603896,606687) PREDICTED: tran ( 317) 207 55.3 2e-07 NP_001305898 (OMIM: 603896,606687) translation ini ( 317) 207 55.3 2e-07 NP_001305897 (OMIM: 603896,606687) translation ini ( 328) 207 55.3 2e-07 NP_001305896 (OMIM: 603896,606687) translation ini ( 492) 207 55.4 2.9e-07 XP_006712195 (OMIM: 603896,606687) PREDICTED: tran ( 507) 207 55.4 3e-07 NP_001305895 (OMIM: 603896,606687) translation ini ( 508) 207 55.4 3e-07 NP_056451 (OMIM: 603896,606687) translation initia ( 522) 207 55.4 3.1e-07 NP_001029288 (OMIM: 603896,606687) translation ini ( 523) 207 55.4 3.1e-07 NP_751945 (OMIM: 603896,606687) translation initia ( 543) 207 55.4 3.2e-07 NP_001305894 (OMIM: 603896,606687) translation ini ( 544) 207 55.4 3.2e-07 NP_055054 (OMIM: 603896,606454) translation initia ( 351) 201 54.0 5.4e-07 >>NP_115661 (OMIM: 615105) methylthioribose-1-phosphate (322 aa) initn: 2069 init1: 2069 opt: 2069 Z-score: 2499.4 bits: 470.7 E(85289): 1.8e-132 Smith-Waterman score: 2069; 100.0% identity (100.0% similar) in 322 aa overlap (1-322:1-322) 10 20 30 40 50 60 pF1KE0 MTLEAIRYSRGSLQILDQLLLPKQSRYEAVGSVHQAWEAIRAMKVRGAPAIALVGCLSLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 MTLEAIRYSRGSLQILDQLLLPKQSRYEAVGSVHQAWEAIRAMKVRGAPAIALVGCLSLA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 VELQAGAGGPGLAALVAFVRDKLSFLVTARPTAVNMARAARDLADVAAREAEREGATEEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 VELQAGAGGPGLAALVAFVRDKLSFLVTARPTAVNMARAARDLADVAAREAEREGATEEA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 VRERRETELCEHWEEHTRQRELPLRGPLGGTVLETRPYNQGARLTAFELVYEQIPATLIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 VRERRETELCEHWEEHTRQRELPLRGPLGGTVLETRPYNQGARLTAFELVYEQIPATLIT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 DSMVAAAMAHRGVSAVVVGADRVVANGDTANKVGTYQLAIVAKHHGIPFYVAAPSSSCDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 DSMVAAAMAHRGVSAVVVGADRVVANGDTANKVGTYQLAIVAKHHGIPFYVAAPSSSCDL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 RLETGKEIIIEERPGQELTDVNGVRIAAPGIGVWNPAFDVTPHDLITGGIITELGVFAPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 RLETGKEIIIEERPGQELTDVNGVRIAAPGIGVWNPAFDVTPHDLITGGIITELGVFAPE 250 260 270 280 290 300 310 320 pF1KE0 ELRTALTTTISSRDGTLDGPQM :::::::::::::::::::::: NP_115 ELRTALTTTISSRDGTLDGPQM 310 320 >>NP_001316501 (OMIM: 615105) methylthioribose-1-phospha (340 aa) initn: 2055 init1: 1090 opt: 1090 Z-score: 1318.6 bits: 252.3 E(85289): 1e-66 Smith-Waterman score: 2023; 94.7% identity (94.7% similar) in 340 aa overlap (1-322:1-340) 10 20 30 40 50 60 pF1KE0 MTLEAIRYSRGSLQILDQLLLPKQSRYEAVGSVHQAWEAIRAMKVRGAPAIALVGCLSLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MTLEAIRYSRGSLQILDQLLLPKQSRYEAVGSVHQAWEAIRAMKVRGAPAIALVGCLSLA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 VELQAGAGGPGLAALVAFVRDKLSFLVTARPTAVNMARAARDLADVAAREAEREGATEEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VELQAGAGGPGLAALVAFVRDKLSFLVTARPTAVNMARAARDLADVAAREAEREGATEEA 70 80 90 100 110 120 130 140 150 160 pF1KE0 VRERRETELCEHWEEHTRQRELPLRGPLGGTVL------------------ETRPYNQGA ::::::::::::::::::::::::::::::::: ::::::::: NP_001 VRERRETELCEHWEEHTRQRELPLRGPLGGTVLGVIRSLHSLGRLEHAFCTETRPYNQGA 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE0 RLTAFELVYEQIPATLITDSMVAAAMAHRGVSAVVVGADRVVANGDTANKVGTYQLAIVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLTAFELVYEQIPATLITDSMVAAAMAHRGVSAVVVGADRVVANGDTANKVGTYQLAIVA 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE0 KHHGIPFYVAAPSSSCDLRLETGKEIIIEERPGQELTDVNGVRIAAPGIGVWNPAFDVTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KHHGIPFYVAAPSSSCDLRLETGKEIIIEERPGQELTDVNGVRIAAPGIGVWNPAFDVTP 250 260 270 280 290 300 290 300 310 320 pF1KE0 HDLITGGIITELGVFAPEELRTALTTTISSRDGTLDGPQM :::::::::::::::::::::::::::::::::::::::: NP_001 HDLITGGIITELGVFAPEELRTALTTTISSRDGTLDGPQM 310 320 330 340 >>NP_001026897 (OMIM: 615105) methylthioribose-1-phospha (369 aa) initn: 1847 init1: 1090 opt: 1090 Z-score: 1318.0 bits: 252.3 E(85289): 1.1e-66 Smith-Waterman score: 1683; 81.6% identity (83.1% similar) in 354 aa overlap (16-322:16-369) 10 20 30 40 50 60 pF1KE0 MTLEAIRYSRGSLQILDQLLLPKQSRYEAVGSVHQAWEAIRAMKVRGAPAIALVGCLSLA ::::::::::::::::::::::::::::::::::::::::::::: NP_001 MTLEAIRYSRGSLQILDQLLLPKQSRYEAVGSVHQAWEAIRAMKVRGAPAIALVGCLSLA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 VELQAGAGGPGLAALVAFVRDKLSFLVTARPTAVNMARAARDLADVAAREAEREGATEEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VELQAGAGGPGLAALVAFVRDKLSFLVTARPTAVNMARAARDLADVAAREAEREGATEEA 70 80 90 100 110 120 130 140 150 pF1KE0 VRERRETELCEHWEEHTRQ---------RELPLR-GPLGG--TVL--------------- :::: . :. :. :.: : .: :: ::: NP_001 VRERVICCTEDMLEKDLRDNRSIGDLGARHLLERVAPSGGKVTVLTHCNTGALATAGYGT 130 140 150 160 170 180 160 170 180 190 pF1KE0 --------------------ETRPYNQGARLTAFELVYEQIPATLITDSMVAAAMAHRGV :::::::::::::::::::::::::::::::::::::::: NP_001 ALGVIRSLHSLGRLEHAFCTETRPYNQGARLTAFELVYEQIPATLITDSMVAAAMAHRGV 190 200 210 220 230 240 200 210 220 230 240 250 pF1KE0 SAVVVGADRVVANGDTANKVGTYQLAIVAKHHGIPFYVAAPSSSCDLRLETGKEIIIEER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SAVVVGADRVVANGDTANKVGTYQLAIVAKHHGIPFYVAAPSSSCDLRLETGKEIIIEER 250 260 270 280 290 300 260 270 280 290 300 310 pF1KE0 PGQELTDVNGVRIAAPGIGVWNPAFDVTPHDLITGGIITELGVFAPEELRTALTTTISSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PGQELTDVNGVRIAAPGIGVWNPAFDVTPHDLITGGIITELGVFAPEELRTALTTTISSR 310 320 330 340 350 360 320 pF1KE0 DGTLDGPQM ::::::::: NP_001 DGTLDGPQM >>XP_011526659 (OMIM: 615105) PREDICTED: methylthioribos (213 aa) initn: 797 init1: 771 opt: 781 Z-score: 949.3 bits: 183.3 E(85289): 3.9e-46 Smith-Waterman score: 781; 79.8% identity (86.3% similar) in 168 aa overlap (1-167:1-165) 10 20 30 40 50 60 pF1KE0 MTLEAIRYSRGSLQILDQLLLPKQSRYEAVGSVHQAWEAIRAMKVRGAPAIALVGCLSLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MTLEAIRYSRGSLQILDQLLLPKQSRYEAVGSVHQAWEAIRAMKVRGAPAIALVGCLSLA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 VELQAGAGGPGLAALVAFVRDKLSFLVTARPTAVNMARAARDLADVAAREAEREGATEEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VELQAGAGGPGLAALVAFVRDKLSFLVTARPTAVNMARAARDLADVAAREAEREGATEEA 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 VRERRETELCEHWEEHTRQ-RELPLRGPLGGTVLETRPYNQGARLTAFELVYEQIPATLI :::: . :. :. : . : ::. : : .:...:.. XP_011 VRERVICCTEDMLEKDLRDNRSI---GDLGARHLLERVAPSGGKVTVLTHCNTGALATAG 130 140 150 160 170 180 190 200 210 220 230 pF1KE0 TDSMVAAAMAHRGVSAVVVGADRVVANGDTANKVGTYQLAIVAKHHGIPFYVAAPSSSCD XP_011 YGTALDVKRSYASIGKSIPGRGNCHCEGPWAGLCSV 180 190 200 210 >>XP_011526658 (OMIM: 615105) PREDICTED: methylthioribos (322 aa) initn: 1503 init1: 771 opt: 781 Z-score: 946.4 bits: 183.4 E(85289): 5.6e-46 Smith-Waterman score: 1429; 79.5% identity (81.1% similar) in 317 aa overlap (1-270:1-317) 10 20 30 40 50 60 pF1KE0 MTLEAIRYSRGSLQILDQLLLPKQSRYEAVGSVHQAWEAIRAMKVRGAPAIALVGCLSLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MTLEAIRYSRGSLQILDQLLLPKQSRYEAVGSVHQAWEAIRAMKVRGAPAIALVGCLSLA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 VELQAGAGGPGLAALVAFVRDKLSFLVTARPTAVNMARAARDLADVAAREAEREGATEEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VELQAGAGGPGLAALVAFVRDKLSFLVTARPTAVNMARAARDLADVAAREAEREGATEEA 70 80 90 100 110 120 130 140 150 pF1KE0 VRERRETELCEHWEEHTRQ---------RELPLR-GPLGG--TVL--------------- :::: . :. :. :.: : .: :: ::: XP_011 VRERVICCTEDMLEKDLRDNRSIGDLGARHLLERVAPSGGKVTVLTHCNTGALATAGYGT 130 140 150 160 170 180 160 170 180 190 pF1KE0 --------------------ETRPYNQGARLTAFELVYEQIPATLITDSMVAAAMAHRGV :::::::::::::::::::::::::::::::::::::::: XP_011 ALGVIRSLHSLGRLEHAFCTETRPYNQGARLTAFELVYEQIPATLITDSMVAAAMAHRGV 190 200 210 220 230 240 200 210 220 230 240 250 pF1KE0 SAVVVGADRVVANGDTANKVGTYQLAIVAKHHGIPFYVAAPSSSCDLRLETGKEIIIEER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SAVVVGADRVVANGDTANKVGTYQLAIVAKHHGIPFYVAAPSSSCDLRLETGKEIIIEER 250 260 270 280 290 300 260 270 280 290 300 310 pF1KE0 PGQELTDVNGVRIAAPGIGVWNPAFDVTPHDLITGGIITELGVFAPEELRTALTTTISSR ::::::::::::::::: XP_011 PGQELTDVNGVRIAAPGFLKRK 310 320 >>NP_001405 (OMIM: 603896,606686) translation initiation (305 aa) initn: 169 init1: 131 opt: 213 Z-score: 261.9 bits: 56.6 E(85289): 7.5e-08 Smith-Waterman score: 213; 31.8% identity (59.9% similar) in 157 aa overlap (152-306:152-300) 130 140 150 160 170 180 pF1KE0 RERRETELCEHWEEHTRQRELPLRGPLGGTVLETRPYNQGARLTAFELVYEQIPATLITD : :..: .: .. : : . ..:.:.. : NP_001 GATILTHAYSRVVLRVLEAAVAAKKRFSVYVTESQPDLSGKKM-AKALCHLNVPVTVVLD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 SMVAAAMAHRGVSAVVVGADRVVANGDTANKVGTYQLAIVAKHHGIPFYVAAPSSSCDLR . :. : . . :.:::. :: :: ::.:: :.:. :: .. ::::.: : . .: NP_001 AAVGYIMEKADL--VIVGAEGVVENGGIINKIGTNQMAVCAKAQNKPFYVVAESFKF-VR 190 200 210 220 230 250 260 270 280 290 pF1KE0 LETGKEIIIEERPGQELTDVNGVRIAAPGIGVW--NPAFDVTPHDLITGGIITELGVFAP : .. .. : . .. ...: : . .: : : .::: ..:.:::..: NP_001 LFPLNQ---QDVPDKFKYKADTLKVAQTGQDLKEEHPWVDYTAPSLITL-LFTDLGVLTP 240 250 260 270 280 290 300 310 320 pF1KE0 EELRTALTTTISSRDGTLDGPQM . : NP_001 SAVSDELIKLYL 300 >>XP_011531449 (OMIM: 603896,606687) PREDICTED: translat (317 aa) initn: 189 init1: 126 opt: 207 Z-score: 254.4 bits: 55.3 E(85289): 2e-07 Smith-Waterman score: 210; 31.0% identity (56.3% similar) in 174 aa overlap (129-296:140-300) 100 110 120 130 140 150 pF1KE0 AARDLADVAAREAEREGATEEAVRERRETELCEHWEEHTRQRELPLRGPLGGTVLETRPY : : : : : : . :...::. XP_011 AQAISRFAYQKISNGDVILVYGCSSLVSRILQEAWTEGRRFRVV---------VVDSRPW 110 120 130 140 150 160 160 170 180 190 200 210 pF1KE0 NQGARLTAFELVYEQIPATLITDSMVAAAMAHRGVSAVVVGADRVVANGDTANKVGTYQL .: : : ::. .::. . . ::... :: :..:: ..:::.. ..::: :: XP_011 LEG-RHTLRSLVHAGVPASYLL--IPAASYVLPEVSKVLLGAHALLANGSVMSRVGTAQL 170 180 190 200 210 220 230 240 250 260 270 pF1KE0 AIVAKHHGIPFYVAAPSSSCDLRLETGKEIIIEERPGQELTDVNGVRIAAPG------IG :.::. :..: : . . :..: . : ..: : ..: . . XP_011 ALVARAHNVPVLVCCETYKFCERVQTDAFVSNELDDPDDLQCKRGEHVALANWQNHASLR 220 230 240 250 260 270 280 290 300 310 320 pF1KE0 VWNPAFDVTPHDLITGGIITELGVFAPEELRTALTTTISSRDGTLDGPQM . : ..:::: .:. .:::::. XP_011 LLNLVYDVTPPELVDL-VITELGMIPCSSVPVVLRVKSSDQ 280 290 300 310 >>NP_001305898 (OMIM: 603896,606687) translation initiat (317 aa) initn: 189 init1: 126 opt: 207 Z-score: 254.4 bits: 55.3 E(85289): 2e-07 Smith-Waterman score: 210; 31.0% identity (56.3% similar) in 174 aa overlap (129-296:140-300) 100 110 120 130 140 150 pF1KE0 AARDLADVAAREAEREGATEEAVRERRETELCEHWEEHTRQRELPLRGPLGGTVLETRPY : : : : : : . :...::. NP_001 AQAISRFAYQKISNGDVILVYGCSSLVSRILQEAWTEGRRFRVV---------VVDSRPW 110 120 130 140 150 160 160 170 180 190 200 210 pF1KE0 NQGARLTAFELVYEQIPATLITDSMVAAAMAHRGVSAVVVGADRVVANGDTANKVGTYQL .: : : ::. .::. . . ::... :: :..:: ..:::.. ..::: :: NP_001 LEG-RHTLRSLVHAGVPASYLL--IPAASYVLPEVSKVLLGAHALLANGSVMSRVGTAQL 170 180 190 200 210 220 230 240 250 260 270 pF1KE0 AIVAKHHGIPFYVAAPSSSCDLRLETGKEIIIEERPGQELTDVNGVRIAAPG------IG :.::. :..: : . . :..: . : ..: : ..: . . NP_001 ALVARAHNVPVLVCCETYKFCERVQTDAFVSNELDDPDDLQCKRGEHVALANWQNHASLR 220 230 240 250 260 270 280 290 300 310 320 pF1KE0 VWNPAFDVTPHDLITGGIITELGVFAPEELRTALTTTISSRDGTLDGPQM . : ..:::: .:. .:::::. NP_001 LLNLVYDVTPPELVDL-VITELGMIPCSSVPVVLRVKSSDQ 280 290 300 310 >>NP_001305897 (OMIM: 603896,606687) translation initiat (328 aa) initn: 189 init1: 126 opt: 207 Z-score: 254.2 bits: 55.3 E(85289): 2e-07 Smith-Waterman score: 210; 31.0% identity (56.3% similar) in 174 aa overlap (129-296:151-311) 100 110 120 130 140 150 pF1KE0 AARDLADVAAREAEREGATEEAVRERRETELCEHWEEHTRQRELPLRGPLGGTVLETRPY : : : : : : . :...::. NP_001 AQAISRFAYQKISNGDVILVYGCSSLVSRILQEAWTEGRRFRVV---------VVDSRPW 130 140 150 160 170 160 170 180 190 200 210 pF1KE0 NQGARLTAFELVYEQIPATLITDSMVAAAMAHRGVSAVVVGADRVVANGDTANKVGTYQL .: : : ::. .::. . . ::... :: :..:: ..:::.. ..::: :: NP_001 LEG-RHTLRSLVHAGVPASYLL--IPAASYVLPEVSKVLLGAHALLANGSVMSRVGTAQL 180 190 200 210 220 220 230 240 250 260 270 pF1KE0 AIVAKHHGIPFYVAAPSSSCDLRLETGKEIIIEERPGQELTDVNGVRIAAPG------IG :.::. :..: : . . :..: . : ..: : ..: . . NP_001 ALVARAHNVPVLVCCETYKFCERVQTDAFVSNELDDPDDLQCKRGEHVALANWQNHASLR 230 240 250 260 270 280 280 290 300 310 320 pF1KE0 VWNPAFDVTPHDLITGGIITELGVFAPEELRTALTTTISSRDGTLDGPQM . : ..:::: .:. .:::::. NP_001 LLNLVYDVTPPELVDL-VITELGMIPCSSVPVVLRVKSSDQ 290 300 310 320 >>NP_001305896 (OMIM: 603896,606687) translation initiat (492 aa) initn: 189 init1: 126 opt: 207 Z-score: 251.3 bits: 55.4 E(85289): 2.9e-07 Smith-Waterman score: 210; 31.0% identity (56.3% similar) in 174 aa overlap (129-296:315-475) 100 110 120 130 140 150 pF1KE0 AARDLADVAAREAEREGATEEAVRERRETELCEHWEEHTRQRELPLRGPLGGTVLETRPY : : : : : : . :...::. NP_001 AQAISRFAYQKISNGDVILVYGCSSLVSRILQEAWTEGRRFRVV---------VVDSRPW 290 300 310 320 330 160 170 180 190 200 210 pF1KE0 NQGARLTAFELVYEQIPATLITDSMVAAAMAHRGVSAVVVGADRVVANGDTANKVGTYQL .: : : ::. .::. . . ::... :: :..:: ..:::.. ..::: :: NP_001 LEG-RHTLRSLVHAGVPASYLL--IPAASYVLPEVSKVLLGAHALLANGSVMSRVGTAQL 340 350 360 370 380 390 220 230 240 250 260 270 pF1KE0 AIVAKHHGIPFYVAAPSSSCDLRLETGKEIIIEERPGQELTDVNGVRIAAPG------IG :.::. :..: : . . :..: . : ..: : ..: . . NP_001 ALVARAHNVPVLVCCETYKFCERVQTDAFVSNELDDPDDLQCKRGEHVALANWQNHASLR 400 410 420 430 440 450 280 290 300 310 320 pF1KE0 VWNPAFDVTPHDLITGGIITELGVFAPEELRTALTTTISSRDGTLDGPQM . : ..:::: .:. .:::::. NP_001 LLNLVYDVTPPELVDL-VITELGMIPCSSVPVVLRVKSSDQ 460 470 480 490 322 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 08:38:39 2016 done: Thu Nov 3 08:38:41 2016 Total Scan time: 7.930 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]