FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0445, 320 aa 1>>>pF1KE0445 320 - 320 aa - 320 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.8276+/-0.00103; mu= 18.1873+/- 0.062 mean_var=63.4978+/-13.548, 0's: 0 Z-trim(102.8): 21 B-trim: 25 in 1/46 Lambda= 0.160951 statistics sampled from 7110 (7126) to 7110 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.587), E-opt: 0.2 (0.219), width: 16 Scan time: 2.460 The best scores are: opt bits E(32554) CCDS55272.1 SLC30A8 gene_id:169026|Hs108|chr8 ( 320) 2068 489.2 1.8e-138 CCDS6322.1 SLC30A8 gene_id:169026|Hs108|chr8 ( 369) 2068 489.2 2.1e-138 CCDS30644.1 SLC30A2 gene_id:7780|Hs108|chr1 ( 372) 1162 278.8 4.4e-75 CCDS272.1 SLC30A2 gene_id:7780|Hs108|chr1 ( 323) 825 200.6 1.4e-51 CCDS1743.1 SLC30A3 gene_id:7781|Hs108|chr2 ( 388) 548 136.3 3.8e-32 CCDS10125.1 SLC30A4 gene_id:7782|Hs108|chr15 ( 429) 432 109.4 5.3e-24 CCDS31026.1 SLC30A10 gene_id:55532|Hs108|chr1 ( 485) 277 73.4 4e-13 >>CCDS55272.1 SLC30A8 gene_id:169026|Hs108|chr8 (320 aa) initn: 2068 init1: 2068 opt: 2068 Z-score: 2599.3 bits: 489.2 E(32554): 1.8e-138 Smith-Waterman score: 2068; 99.4% identity (99.4% similar) in 320 aa overlap (1-320:1-320) 10 20 30 40 50 60 pF1KE0 MYHCHSGSKPTEKGANEYAYAKWKLCSASAICFIFMIAEVVGGHIAGSLAVVTDAAHLLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 MYHCHSGSKPTEKGANEYAYAKWKLCSASAICFIFMIAEVVGGHIAGSLAVVTDAAHLLI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 DLTSFLLSLFSLWLSSKPPSKRLTFGWHRAEILGALLSILCIWVVTGVLVYLACERLLYP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 DLTSFLLSLFSLWLSSKPPSKRLTFGWHRAEILGALLSILCIWVVTGVLVYLACERLLYP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 DYQIQATVMIIVSSCAVAANIVLTVVLHQRCLGHNHKEVQANASVRAAFVHAPGDLFQSI :::::::::::::::::::::::::::::::::::::::::::::::::::: ::::::: CCDS55 DYQIQATVMIIVSSCAVAANIVLTVVLHQRCLGHNHKEVQANASVRAAFVHALGDLFQSI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 SVLISALIIYFKPEYKIADPICTFIFSILVLASTITILKDFSILLMEGVPKSLNYSGVKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 SVLISALIIYFKPEYKIADPICTFIFSILVLASTITILKDFSILLMEGVPKSLNYSGVKE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 LILAVDGVLSVHCLHIWSLTMNQVILSAHVATAASRDSQVVRREIAKALSKSFTMHSLTI :::::::::::: ::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 LILAVDGVLSVHSLHIWSLTMNQVILSAHVATAASRDSQVVRREIAKALSKSFTMHSLTI 250 260 270 280 290 300 310 320 pF1KE0 QMESPVDQDPDCLFCEDPCD :::::::::::::::::::: CCDS55 QMESPVDQDPDCLFCEDPCD 310 320 >>CCDS6322.1 SLC30A8 gene_id:169026|Hs108|chr8 (369 aa) initn: 2068 init1: 2068 opt: 2068 Z-score: 2598.4 bits: 489.2 E(32554): 2.1e-138 Smith-Waterman score: 2068; 99.4% identity (99.4% similar) in 320 aa overlap (1-320:50-369) 10 20 30 pF1KE0 MYHCHSGSKPTEKGANEYAYAKWKLCSASA :::::::::::::::::::::::::::::: CCDS63 FTLESVELQQKPVNKDQCPRERPEELESGGMYHCHSGSKPTEKGANEYAYAKWKLCSASA 20 30 40 50 60 70 40 50 60 70 80 90 pF1KE0 ICFIFMIAEVVGGHIAGSLAVVTDAAHLLIDLTSFLLSLFSLWLSSKPPSKRLTFGWHRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 ICFIFMIAEVVGGHIAGSLAVVTDAAHLLIDLTSFLLSLFSLWLSSKPPSKRLTFGWHRA 80 90 100 110 120 130 100 110 120 130 140 150 pF1KE0 EILGALLSILCIWVVTGVLVYLACERLLYPDYQIQATVMIIVSSCAVAANIVLTVVLHQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 EILGALLSILCIWVVTGVLVYLACERLLYPDYQIQATVMIIVSSCAVAANIVLTVVLHQR 140 150 160 170 180 190 160 170 180 190 200 210 pF1KE0 CLGHNHKEVQANASVRAAFVHAPGDLFQSISVLISALIIYFKPEYKIADPICTFIFSILV :::::::::::::::::::::: ::::::::::::::::::::::::::::::::::::: CCDS63 CLGHNHKEVQANASVRAAFVHALGDLFQSISVLISALIIYFKPEYKIADPICTFIFSILV 200 210 220 230 240 250 220 230 240 250 260 270 pF1KE0 LASTITILKDFSILLMEGVPKSLNYSGVKELILAVDGVLSVHCLHIWSLTMNQVILSAHV :::::::::::::::::::::::::::::::::::::::::: ::::::::::::::::: CCDS63 LASTITILKDFSILLMEGVPKSLNYSGVKELILAVDGVLSVHSLHIWSLTMNQVILSAHV 260 270 280 290 300 310 280 290 300 310 320 pF1KE0 ATAASRDSQVVRREIAKALSKSFTMHSLTIQMESPVDQDPDCLFCEDPCD :::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 ATAASRDSQVVRREIAKALSKSFTMHSLTIQMESPVDQDPDCLFCEDPCD 320 330 340 350 360 >>CCDS30644.1 SLC30A2 gene_id:7780|Hs108|chr1 (372 aa) initn: 1139 init1: 606 opt: 1162 Z-score: 1461.4 bits: 278.8 E(32554): 4.4e-75 Smith-Waterman score: 1162; 52.8% identity (82.3% similar) in 322 aa overlap (2-320:51-372) 10 20 30 pF1KE0 MYHCHSGSKPTEKGANEYAYAKWKLCSASAI .:::. . : . . . :. .: :::: CCDS30 GSLWQEGAGWIPLPRPGLDLQAIELAAQSNHHCHAQKGPDSHCDPKKGKAQRQLYVASAI 30 40 50 60 70 80 40 50 60 70 80 90 pF1KE0 CFIFMIAEVVGGHIAGSLAVVTDAAHLLIDLTSFLLSLFSLWLSSKPPSKRLTFGWHRAE :..:::.:::::..: ::::.::::::: :..:.:.::::::.::.: .: ..:::.::: CCDS30 CLLFMIGEVVGGYLAHSLAVMTDAAHLLTDFASMLISLFSLWMSSRPATKTMNFGWQRAE 90 100 110 120 130 140 100 110 120 130 140 150 pF1KE0 ILGALLSILCIWVVTGVLVYLACERLLYPDYQIQATVMIIVSSCAVAANIVLTVVLHQRC :::::.:.: :::::::::::: :::. ::.:.. .:.:.:.::::.::.. ..::: CCDS30 ILGALVSVLSIWVVTGVLVYLAVERLISGDYEIDGGTMLITSGCAVAVNIIMGLTLHQSG 150 160 170 180 190 200 160 170 180 190 200 pF1KE0 LGHNH---KEVQANASVRAAFVHAPGDLFQSISVLISALIIYFKPEYKIADPICTFIFSI ::.: .. . : ::::::.:. ::..::..::..: :.::::::: .::::::.::: CCDS30 HGHSHGTTNQQEENPSVRAAFIHVIGDFMQSMGVLVAAYILYFKPEYKYVDPICTFVFSI 210 220 230 240 250 260 210 220 230 240 250 260 pF1KE0 LVLASTITILKDFSILLMEGVPKSLNYSGVKELILAVDGVLSVHCLHIWSLTMNQVILSA :::..:.:::.: ..::::.::......:..:.:.:.:: ..: ::::.::. : .::. CCDS30 LVLGTTLTILRDVILVLMEGTPKGVDFTAVRDLLLSVEGVEALHSLHIWALTVAQPVLSV 270 280 290 300 310 320 270 280 290 300 310 320 pF1KE0 HVATAASRDSQVVRREIAKALSKSFTMHSLTIQMESPVDQDPDCLFCEDPCD :.: : . :.:.: . .. :. .: .:..:::.:. .. :: :. : : CCDS30 HIAIAQNTDAQAVLKTASSRLQGKFHFHTVTIQIEDYSEDMKDCQACQGPSD 330 340 350 360 370 >>CCDS272.1 SLC30A2 gene_id:7780|Hs108|chr1 (323 aa) initn: 896 init1: 547 opt: 825 Z-score: 1039.3 bits: 200.6 E(32554): 1.4e-51 Smith-Waterman score: 825; 51.9% identity (82.4% similar) in 233 aa overlap (91-320:91-323) 70 80 90 100 110 120 pF1KE0 DLTSFLLSLFSLWLSSKPPSKRLTFGWHRAEILGALLSILCIWVVTGVLVYLACERLLYP ::::::.:.: :::::::::::: :::. CCDS27 SHCDPKKGKAQRQLYVASAICLLFMIGEVVEILGALVSVLSIWVVTGVLVYLAVERLISG 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 DYQIQATVMIIVSSCAVAANIVLTVVLHQRCLGHNH---KEVQANASVRAAFVHAPGDLF ::.:.. .:.:.:.::::.::.. ..::: ::.: .. . : ::::::.:. ::.. CCDS27 DYEIDGGTMLITSGCAVAVNIIMGLTLHQSGHGHSHGTTNQQEENPSVRAAFIHVIGDFM 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE0 QSISVLISALIIYFKPEYKIADPICTFIFSILVLASTITILKDFSILLMEGVPKSLNYSG ::..::..: :.::::::: .::::::.::::::..:.:::.: ..::::.::...... CCDS27 QSMGVLVAAYILYFKPEYKYVDPICTFVFSILVLGTTLTILRDVILVLMEGTPKGVDFTA 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE0 VKELILAVDGVLSVHCLHIWSLTMNQVILSAHVATAASRDSQVVRREIAKALSKSFTMHS :..:.:.:.:: ..: ::::.::. : .::.:.: : . :.:.: . .. :. .: .:. CCDS27 VRDLLLSVEGVEALHSLHIWALTVAQPVLSVHIAIAQNTDAQAVLKTASSRLQGKFHFHT 250 260 270 280 290 300 300 310 320 pF1KE0 LTIQMESPVDQDPDCLFCEDPCD .:::.:. .. :: :. : : CCDS27 VTIQIEDYSEDMKDCQACQGPSD 310 320 >>CCDS1743.1 SLC30A3 gene_id:7781|Hs108|chr2 (388 aa) initn: 975 init1: 538 opt: 548 Z-score: 690.6 bits: 136.3 E(32554): 3.8e-32 Smith-Waterman score: 961; 44.7% identity (71.8% similar) in 333 aa overlap (2-318:53-385) 10 20 30 pF1KE0 MYHCHSGSKPTEKGANEYAYAKWKLCSASAI .::: : . : .:. .: .: :. CCDS17 GAGGSLRLKSLFTEPSEPLPEESKPVEMPFHHCHRDPLPPPGLTPERLHARRQLYAACAV 30 40 50 60 70 80 40 50 60 70 80 90 pF1KE0 CFIFMIAEVVGGHIAGSLAVVTDAAHLLIDLTSFLLSLFSLWLSSKPPSKRLTFGWHRAE ::.:: .:::::..: :::..::::::: :. :.. ::::::::..: .. .::::::.: CCDS17 CFVFMAGEVVGGYLAHSLAIMTDAAHLLADVGSMMGSLFSLWLSTRPATRTMTFGWHRSE 90 100 110 120 130 140 100 110 120 130 140 150 pF1KE0 ILGALLSILCIWVVTGVLVYLACERLLYPDYQIQATVMIIVSSCAVAANIVLTVVLHQRC :::: :.. .:.:::.:.::: :::. ::.:.. .:....: :: ::.... :::: CCDS17 TLGALASVVSLWMVTGILLYLAFVRLLHSDYHIEGGAMLLTASIAVCANLLMAFVLHQAG 150 160 170 180 190 200 160 170 180 190 pF1KE0 LGHNHKEVQA----------------NASVRAAFVHAPGDLFQSISVLISALIIYFKPEY :.: : :.::::::::. :::.::..:: ....:::::.: CCDS17 PPHSHGSRGAEYAPLEEGPEEPLPLGNTSVRAAFVHVLGDLLQSFGVLAASILIYFKPQY 210 220 230 240 250 260 200 210 220 230 240 250 pF1KE0 KIADPICTFIFSILVLASTITILKDFSILLMEGVPKSLNYSGVKELILAVDGVLSVHCLH : :::: ::.::: .:.:: :.: .::::.:..... :.. .:.: :: ..: :: CCDS17 KAADPISTFLFSICALGSTAPTLRDVLRILMEGTPRNVGFEPVRDTLLSVPGVRATHELH 270 280 290 300 310 320 260 270 280 290 300 310 pF1KE0 IWSLTMNQVILSAHVATAASRDSQVVRREIAKALSKSFTMHSLTIQMESPVDQDPDCLFC .:.::.. . :::.: .. : ..: : .. : . : . : :.:.:. . .:: : CCDS17 LWALTLTYHVASAHLAIDSTADPEAVLAEASSRLYSRFGFSSCTLQVEQYQPEMAQCLRC 330 340 350 360 370 380 320 pF1KE0 EDPCD ..: CCDS17 QEPPQA >>CCDS10125.1 SLC30A4 gene_id:7782|Hs108|chr15 (429 aa) initn: 786 init1: 426 opt: 432 Z-score: 544.4 bits: 109.4 E(32554): 5.3e-24 Smith-Waterman score: 802; 39.9% identity (70.0% similar) in 333 aa overlap (4-316:95-425) 10 20 30 pF1KE0 MYHCHSGSKPTEKGANEYAYAKWKLCSASAICF : . :: : . .: .: :... . CCDS10 AHPTLQADDDSLLDQDLPLTNSQLSLKVDSCDNCSKQRE--ILKQRKVKARLTIAAVLYL 70 80 90 100 110 120 40 50 60 70 80 90 pF1KE0 IFMIAEVVGGHIAGSLAVVTDAAHLLIDLTSFLLSLFSLWLSSKPPSKRLTFGWHRAEIL .:::.:.:::.::.:::..::: :.: ::....:.:..:::::: :.::.:::.:: :.: CCDS10 LFMIGELVGGYIANSLAIMTDALHMLTDLSAIILTLLALWLSSKSPTKRFTFGFHRLEVL 130 140 150 160 170 180 100 110 120 130 140 150 pF1KE0 GALLSILCIWVVTGVLVYLACERLLYPDYQIQATVMIIVSSCAVAANIVLTVVLHQRCLG .:..:.: .... : :.: : .: .. .:.:.. .:.:... .::.:... .:.: CCDS10 SAMISVLLVYILMGFLLYEAVQRTIHMNYEINGDIMLITAAVGVAVNVIMGFLLNQSGHR 190 200 210 220 230 240 160 170 180 190 pF1KE0 HNHKEV-----------------QANASVRAAFVHAPGDLFQSISVLISALIIYFKPEYK :.:.. : . .:::::::: ::: ::..:::.: :: :::::: CCDS10 HSHSHSLPSNSPTRGSGCERNHGQDSLAVRAAFVHALGDLVQSVGVLIAAYIIRFKPEYK 250 260 270 280 290 300 200 210 220 230 240 250 pF1KE0 IADPICTFIFSILVLASTITILKDFSILLMEGVPKSLNYSGVKELILAVDGVLSVHCLHI :::::::..::.:: .:. :. : ....::::. :: . .:: .. .. : ::. :.: CCDS10 IADPICTYVFSLLVAFTTFRIIWDTVVIILEGVPSHLNVDYIKEALMKIEDVYSVEDLNI 310 320 330 340 350 360 260 270 280 290 300 310 pF1KE0 WSLTMNQVILSAHVATAASRDSQV--VRREIAKALSKSFTMHSLTIQMESPVDQ-DPDCL :::: .. .:. . .:. :. . . : ..: :. :::..: .. : : CCDS10 WSLTSGKSTAIVHIQLIPGSSSKWEEVQSKANHLLLNTFGMYRCTIQLQSYRQEVDRTCA 370 380 390 400 410 420 320 pF1KE0 FCEDPCD :. CCDS10 NCQSSSP >>CCDS31026.1 SLC30A10 gene_id:55532|Hs108|chr1 (485 aa) initn: 225 init1: 167 opt: 277 Z-score: 349.2 bits: 73.4 E(32554): 4e-13 Smith-Waterman score: 282; 30.3% identity (64.0% similar) in 178 aa overlap (157-319:229-404) 130 140 150 160 170 180 pF1KE0 TVMIIVSSCAVAANIVLTVVLHQRCLGHNHKEVQANA-SVRAAFVHAPGDLFQSISVLIS :: ...: ..:....:. :: . :. :.:. CCDS31 ERKREKGATVFANVAGDSFNTQNEPEDMMKKEKKSEALNIRGVLLHVMGDALGSVVVVIT 200 210 220 230 240 250 190 200 210 220 230 pF1KE0 ALIIYFKPEYKIADPI---C------TFIFSILVLASTITILKDFSILLMEGVPKSLNYS :.:.: : : :: : : .. :..:.:.. ..:. . .:.. :::..:. CCDS31 AIIFYVLP-LKSEDPCNWQCYIDPSLTVLMVIIILSSAFPLIKETAAILLQMVPKGVNME 260 270 280 290 300 310 240 250 260 270 280 290 pF1KE0 GVKELILAVDGVLSVHCLHIWSLTMNQVILSAHVATAASRDSQVVRREIAKALSKSFTMH . . :: :. ::: .::: :. ...: . :. .: : . .: . . .. .: CCDS31 ELMSKLSAVPGISSVHEVHIWELVSGKIIATLHIKYPKDRGYQDASTKIREIFHHA-GIH 320 330 340 350 360 370 300 310 320 pF1KE0 SLTIQMES-----PVDQDPDCLFCEDPCD ..:::.:. :..: :.:..:: CCDS31 NVTIQFENVDLKEPLEQKDLLLLCNSPCISKGCAKQLCCPPGALPLAHVNGCAEHNGGPS 380 390 400 410 420 430 320 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 08:29:47 2016 done: Thu Nov 3 08:29:48 2016 Total Scan time: 2.460 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]