FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0450, 448 aa 1>>>pF1KE0450 448 - 448 aa - 448 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.8985+/-0.00084; mu= 15.1843+/- 0.050 mean_var=82.3418+/-17.147, 0's: 0 Z-trim(108.2): 27 B-trim: 547 in 1/49 Lambda= 0.141340 statistics sampled from 10046 (10056) to 10046 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.668), E-opt: 0.2 (0.309), width: 16 Scan time: 3.330 The best scores are: opt bits E(32554) CCDS48195.1 SLC10A3 gene_id:8273|Hs108|chrX ( 448) 2871 595.1 4.6e-170 CCDS14755.1 SLC10A3 gene_id:8273|Hs108|chrX ( 477) 2083 434.5 1.1e-121 CCDS34915.1 SLC10A5 gene_id:347051|Hs108|chr8 ( 438) 926 198.5 1.1e-50 CCDS3614.1 SLC10A6 gene_id:345274|Hs108|chr4 ( 377) 452 101.8 1.2e-21 CCDS9797.1 SLC10A1 gene_id:6554|Hs108|chr14 ( 349) 438 99.0 8.3e-21 CCDS9506.1 SLC10A2 gene_id:6555|Hs108|chr13 ( 348) 434 98.1 1.5e-20 CCDS3482.1 SLC10A4 gene_id:201780|Hs108|chr4 ( 437) 416 94.5 2.2e-19 >>CCDS48195.1 SLC10A3 gene_id:8273|Hs108|chrX (448 aa) initn: 2871 init1: 2871 opt: 2871 Z-score: 3166.6 bits: 595.1 E(32554): 4.6e-170 Smith-Waterman score: 2871; 100.0% identity (100.0% similar) in 448 aa overlap (1-448:1-448) 10 20 30 40 50 60 pF1KE0 MVLMQDKGSSQQWPGLGGEGGGTGPLSMLRAALLLISLPWGAQGTASTSLSTAGGHTVPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS48 MVLMQDKGSSQQWPGLGGEGGGTGPLSMLRAALLLISLPWGAQGTASTSLSTAGGHTVPP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 TGGRYLSIGDGSVMEFEFPEDSEGIIVISSQYPGQANRTAPGPMLRVTSLDTEVLTIKNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS48 TGGRYLSIGDGSVMEFEFPEDSEGIIVISSQYPGQANRTAPGPMLRVTSLDTEVLTIKNL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 VDAHEAPPTLIEERRDFCIKVSPAEDTPATLSADLAHFSENPILYLLLPLIFVNKCSFGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS48 VDAHEAPPTLIEERRDFCIKVSPAEDTPATLSADLAHFSENPILYLLLPLIFVNKCSFGC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 KVELEVLKGLMQSPQPMLLGLLGQFLVMPLYAFLMAKVFMLPKALALGLIITCSSPGGGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS48 KVELEVLKGLMQSPQPMLLGLLGQFLVMPLYAFLMAKVFMLPKALALGLIITCSSPGGGG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 SYLFSLLLGGDVTLAISMTFLSTVAATGFLPLSSAIYSRLLSIHETLHVPISKILGTLLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS48 SYLFSLLLGGDVTLAISMTFLSTVAATGFLPLSSAIYSRLLSIHETLHVPISKILGTLLF 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 IAIPIAVGVLIKSKLPKFSQLLLQVVKPFSFVLLLGGLFLAYRMGVFILAGIRLPIVLVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS48 IAIPIAVGVLIKSKLPKFSQLLLQVVKPFSFVLLLGGLFLAYRMGVFILAGIRLPIVLVG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 ITVPLVGLLVGYCLATCLKLPVAQRRTVSIEVGVQNSLLALAMLQLSLRRLQADYASQAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS48 ITVPLVGLLVGYCLATCLKLPVAQRRTVSIEVGVQNSLLALAMLQLSLRRLQADYASQAP 370 380 390 400 410 420 430 440 pF1KE0 FIVALSGTSEMLALVIGHFIYSSLFPVP :::::::::::::::::::::::::::: CCDS48 FIVALSGTSEMLALVIGHFIYSSLFPVP 430 440 >>CCDS14755.1 SLC10A3 gene_id:8273|Hs108|chrX (477 aa) initn: 2083 init1: 2083 opt: 2083 Z-score: 2297.8 bits: 434.5 E(32554): 1.1e-121 Smith-Waterman score: 2803; 93.9% identity (93.9% similar) in 477 aa overlap (1-448:1-477) 10 20 30 40 50 60 pF1KE0 MVLMQDKGSSQQWPGLGGEGGGTGPLSMLRAALLLISLPWGAQGTASTSLSTAGGHTVPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 MVLMQDKGSSQQWPGLGGEGGGTGPLSMLRAALLLISLPWGAQGTASTSLSTAGGHTVPP 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 TGGRYLSIGDGSVMEFEFPEDSEGIIVISSQYPGQANRTAPGPMLRVTSLDTEVLTIKN- ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 TGGRYLSIGDGSVMEFEFPEDSEGIIVISSQYPGQANRTAPGPMLRVTSLDTEVLTIKNV 70 80 90 100 110 120 120 130 140 150 pF1KE0 ----------------------------LVDAHEAPPTLIEERRDFCIKVSPAEDTPATL :::::::::::::::::::::::::::::::: CCDS14 SAITWGGGGGFVVSIHSGLAGLAPLHIQLVDAHEAPPTLIEERRDFCIKVSPAEDTPATL 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE0 SADLAHFSENPILYLLLPLIFVNKCSFGCKVELEVLKGLMQSPQPMLLGLLGQFLVMPLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 SADLAHFSENPILYLLLPLIFVNKCSFGCKVELEVLKGLMQSPQPMLLGLLGQFLVMPLY 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE0 AFLMAKVFMLPKALALGLIITCSSPGGGGSYLFSLLLGGDVTLAISMTFLSTVAATGFLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 AFLMAKVFMLPKALALGLIITCSSPGGGGSYLFSLLLGGDVTLAISMTFLSTVAATGFLP 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE0 LSSAIYSRLLSIHETLHVPISKILGTLLFIAIPIAVGVLIKSKLPKFSQLLLQVVKPFSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 LSSAIYSRLLSIHETLHVPISKILGTLLFIAIPIAVGVLIKSKLPKFSQLLLQVVKPFSF 310 320 330 340 350 360 340 350 360 370 380 390 pF1KE0 VLLLGGLFLAYRMGVFILAGIRLPIVLVGITVPLVGLLVGYCLATCLKLPVAQRRTVSIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 VLLLGGLFLAYRMGVFILAGIRLPIVLVGITVPLVGLLVGYCLATCLKLPVAQRRTVSIE 370 380 390 400 410 420 400 410 420 430 440 pF1KE0 VGVQNSLLALAMLQLSLRRLQADYASQAPFIVALSGTSEMLALVIGHFIYSSLFPVP ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 VGVQNSLLALAMLQLSLRRLQADYASQAPFIVALSGTSEMLALVIGHFIYSSLFPVP 430 440 450 460 470 >>CCDS34915.1 SLC10A5 gene_id:347051|Hs108|chr8 (438 aa) initn: 968 init1: 888 opt: 926 Z-score: 1023.4 bits: 198.5 E(32554): 1.1e-50 Smith-Waterman score: 926; 42.7% identity (76.1% similar) in 330 aa overlap (107-436:91-416) 80 90 100 110 120 130 pF1KE0 EFPEDSEGIIVISSQYPGQANRTAPGPMLRVTSLDTEVLTIKNLVDAHEAPPTLIEERRD ::. . :. . .: :.. :::: .. CCDS34 FVKIEDPKILQMVNVAKKISSDATNFTINLVTDEEGETNVTIQLWDSEGRQERLIEEIKN 70 80 90 100 110 120 140 150 160 170 180 190 pF1KE0 FCIKVSPAEDTPATLSADLAHFSENPILYLLLPLIFVNKCSFGCKVELEVLKGLMQSPQP .:: .:. :.: . :...: ::.:.::::..:::.::::.::.... . . : : CCDS34 VKVKVLKQKDS--LLQAPM-HIDRN-ILMLILPLILLNKCAFGCKIELQLFQTVWKRPLP 130 140 150 160 170 200 210 220 230 240 250 pF1KE0 MLLGLLGQFLVMPLYAFLMAKVFMLPKALALGLIITCSSPGGGGSYLFSLLLGGDVTLAI ..:: . ::..::. .::.... ::.: :.:...::. :::::.:::.::: :: :::: CCDS34 VILGAVTQFFLMPFCGFLLSQIVALPEAQAFGVVMTCTCPGGGGGYLFALLLDGDFTLAI 180 190 200 210 220 230 260 270 280 290 300 310 pF1KE0 SMTFLSTVAATGFLPLSSAIYSRLLSIHETLHVPISKILGTLLFIAIPIAVGVLIKSKLP :: ::. : ..:..: ::::.:.. :.:.:.:::..::::: .:...:..:: ..: CCDS34 LMTCTSTLLALIMMPVNSYIYSRILGLSGTFHIPVSKIVSTLLFILVPVSIGIVIKHRIP 240 250 260 270 280 290 320 330 340 350 360 370 pF1KE0 KFSQLLLQVVKPFSFVLLLGGLFLAYRMGVFILAGIRLPIVLVGITVPLVGLLVGYCLAT . ...: ....:.::.:.. :..:.. .:. .: : ..:.:. :: .::: :: .: CCDS34 EKASFLERIIRPLSFILMFVGIYLTFTVGLVFLKTDNLEVILLGLLVPALGLLFGYSFAK 300 310 320 330 340 350 380 390 400 410 420 430 pF1KE0 CLKLPVAQRRTVSIEVGVQNSLLALAMLQLSLRRLQADYASQAPFIVALSGTSEMLALVI ::. .::.:: :. ::.::::..:::. . .:. :: ::: ::. . ::: ... CCDS34 VCTLPLPVCKTVAIESGMLNSFLALAVIQLSFPQSKANLASVAPFTVAMCSGCEMLLIIL 360 370 380 390 400 410 440 pF1KE0 GHFIYSSLFPVP CCDS34 VYKAKKRCIFFLQDKRKRNFLI 420 430 >>CCDS3614.1 SLC10A6 gene_id:345274|Hs108|chr4 (377 aa) initn: 454 init1: 357 opt: 452 Z-score: 502.0 bits: 101.8 E(32554): 1.2e-21 Smith-Waterman score: 452; 31.7% identity (63.5% similar) in 271 aa overlap (143-408:12-278) 120 130 140 150 160 170 pF1KE0 EVLTIKNLVDAHEAPPTLIEERRDFCIKVSPAEDTPATLSADLAHFSENPILYLLLPLIF ::... : . : .. ... .. .. CCDS36 MRANCSSSSACPANSSEEELPVGLEVHGNLELVFTVVSTVM 10 20 30 40 180 190 200 210 220 230 pF1KE0 VN--KCSFGCKVELEVLKGLMQSPQPMLLGLLGQFLVMPLYAFLMAKVFMLPKALALGLI .. :.::.::.. : . .. : . .::: :: .::. :.:.: : : . :.... CCDS36 MGLLMFSLGCSVEIRKLWSHIRRPWGIAVGLLCQFGLMPFTAYLLAISFSLKPVQAIAVL 50 60 70 80 90 100 240 250 260 270 280 290 pF1KE0 ITCSSPGGGGSYLFSLLLGGDVTLAISMTFLSTVAATGFLPLSSAIYSRLLSIHETLHVP : ::: : .:.. . ::. :.:::: ::::: :..:: .:. :....: .: CCDS36 IMGCCPGGTISNIFTFWVDGDMDLSISMTTCSTVAALGMMPLCIYLYTWSWSLQQNLTIP 110 120 130 140 150 160 300 310 320 330 340 350 pF1KE0 ISKILGTLLFIAIPIAVGVLIKSKLPKFSQLLLQVVKPFSFVLLLGGLFLAYRMGVFILA ..: ::. ..::.: :: .. . :: :...:.. . :::: .. :: . CCDS36 YQNIGITLVCLTIPVAFGVYVNYRWPKQSKIILKIGAVVGGVLLL----VVAVAGVVLAK 170 180 190 200 210 360 370 380 390 400 pF1KE0 GI---RLPIVLVGITVPLVGLLVGYCLATCLKLPVAQRRTVSIEVGVQNSLLALAMLQLS : . .. ... ::.: ..:. :: . . ::.:.:.:.:: . ..::::: CCDS36 GSWNSDITLLTISFIFPLIGHVTGFLLALFTHQSWQRCRTISLETGAQNIQMCITMLQLS 220 230 240 250 260 270 410 420 430 440 pF1KE0 LRRLQADYASQAPFIVALSGTSEMLALVIGHFIYSSLFPVP . CCDS36 FTAEHLVQMLSFPLAYGLFQLIDGFLIVAAYQTYKRRLKNKHGKKNSGCTEVCHTRKSTS 280 290 300 310 320 330 >>CCDS9797.1 SLC10A1 gene_id:6554|Hs108|chr14 (349 aa) initn: 409 init1: 271 opt: 438 Z-score: 487.1 bits: 99.0 E(32554): 8.3e-21 Smith-Waterman score: 438; 33.1% identity (65.7% similar) in 248 aa overlap (166-408:30-274) 140 150 160 170 180 190 pF1KE0 DFCIKVSPAEDTPATLSADLAHFSENPILYLLLPLIFVNKCSFGCKVELEVLKGLMQSPQ .:. ..: :.:: .:. .:. . .:. CCDS97 MEAHNASAPFNFTLPPNFGKRPTDLALSVILVFMLFFIMLSLGCTMEFSKIKAHLWKPK 10 20 30 40 50 200 210 220 230 240 250 pF1KE0 PMLLGLLGQFLVMPLYAFLMAKVFMLPKALALGLIITCSSPGGGGSYLFSLLLGGDVTLA . ..:..:. .::: ::...::: : . ::.... ::::. : .::: . ::..:. CCDS97 GLAIALVAQYGIMPLTAFVLGKVFRLKNIEALAILVCGCSPGGNLSNVFSLAMKGDMNLS 60 70 80 90 100 110 260 270 280 290 300 310 pF1KE0 ISMTFLSTVAATGFLPLSSAIYSRLLSIHETL-HVPISKILGTLLFIAIPIAVGVLIKSK : :: :: : :..:: :::: . . .:: . :. .:... :: ..:...::: CCDS97 IVMTTCSTFCALGMMPLLLYIYSRGIYDGDLKDKVPYKGIVISLVLVLIPCTIGIVLKSK 120 130 140 150 160 170 320 330 340 350 360 370 pF1KE0 LPKFSQLLLQVVKPFSFVLLLGGLFL----AYRMGVFILAGIRLPIVLVGITVPLVGLLV : : . :.: ...:: .. . : .: :. .. .. .. .:..:.:. CCDS97 RP---QYMRYVIKGGMIIILLCSVAVTVLSAINVGKSIMFAMTPLLIATSSLMPFIGFLL 180 190 200 210 220 230 380 390 400 410 420 430 pF1KE0 GYCLATCLKLPVAQRRTVSIEVGVQNSLLALAMLQLSLRRLQADYASQAPFIVALSGTSE :: :.. . : :::::.:.: :: : ..:.... CCDS97 GYVLSALFCLNGRCRRTVSMETGCQNVQLCSTILNVAFPPEVIGPLFFFPLLYMIFQLGE 240 250 260 270 280 290 440 pF1KE0 MLALVIGHFIYSSLFPVP CCDS97 GLLLIAIFWCYEKFKTPKDKTKMIYTAATTEETIPGALGNGTYKGEDCSPCTA 300 310 320 330 340 >>CCDS9506.1 SLC10A2 gene_id:6555|Hs108|chr13 (348 aa) initn: 336 init1: 225 opt: 434 Z-score: 482.7 bits: 98.1 E(32554): 1.5e-20 Smith-Waterman score: 434; 28.8% identity (64.1% similar) in 281 aa overlap (163-440:37-309) 140 150 160 170 180 190 pF1KE0 ERRDFCIKVSPAEDTPATLSADLAHFSENPILYLLLPLIFVNKCSFGCKVELEVLKGLMQ .: .:: :.. :.::.::.. . : .. CCDS95 CVDNATVCSGASCVVPESNFNNILSVVLSTVLTILLALVMF---SMGCNVEIKKFLGHIK 10 20 30 40 50 60 200 210 220 230 240 250 pF1KE0 SPQPMLLGLLGQFLVMPLYAFLMAKVF-MLPKALALGLIITCSSPGGGGSYLFSLLLGGD : . .:.: :: .::: .:... .: .:: .. ::: : ::: .: ... . :: CCDS95 RPWGICVGFLCQFGIMPLTGFILSVAFDILPLQAVVVLIIGCC-PGGTASNILAYWVDGD 70 80 90 100 110 120 260 270 280 290 300 310 pF1KE0 VTLAISMTFLSTVAATGFLPLSSAIYSRLLSIHETLHVPISKILGTLLFIAIPIAVGVLI . :..::: ::. : :..:: ::... .. .: ..: .:. ...:...:... CCDS95 MDLSVSMTTCSTLLALGMMPLCLLIYTKMWVDSGSIVIPYDNIGTSLVSLVVPVSIGMFV 130 140 150 160 170 180 320 330 340 350 360 pF1KE0 KSKLPKFSQLLLQVVKPFSFVLLLGGLFLAYRMGVFIL-AGIRLP-IVLVGITVPLVGLL . : :. ....:.. . . .:.. ..: :.. : : : . ..: :..: CCDS95 NHKWPQKAKIILKIGSIAGAILIV---LIAVVGGILYQSAWIIAPKLWIIGTIFPVAGYS 190 200 210 220 230 370 380 390 400 410 420 pF1KE0 VGYCLATCLKLPVAQRRTVSIEVGVQNSLLALAMLQLSLRRLQADYASQAPFIVALSGTS .:. :: :: . :::..:.:.::. : ...:::. . . . :.: .. . CCDS95 LGFLLARIAGLPWYRCRTVAFETGMQNTQLCSTIVQLSFTPEELNVVFTFPLIYSIFQLA 240 250 260 270 280 290 430 440 pF1KE0 EMLALVIGHFIYSSLFPVP . :. .: .. CCDS95 -FAAIFLGFYVAYKKCHGKNKAEIPESKENGTEPESSFYKANGGFQPDEK 300 310 320 330 340 >>CCDS3482.1 SLC10A4 gene_id:201780|Hs108|chr4 (437 aa) initn: 394 init1: 220 opt: 416 Z-score: 461.3 bits: 94.5 E(32554): 2.2e-19 Smith-Waterman score: 430; 29.2% identity (56.5% similar) in 391 aa overlap (56-443:19-387) 30 40 50 60 70 80 pF1KE0 LSMLRAALLLISLPWGAQGTASTSLSTAGGHTVPPTGGRYLSIGDGSVMEFEFPEDSEGI .:. :... :.: :. . . : .: : CCDS34 MDGNDNVTLLFAPLLRDNYTLAPNAS---SLGPGTDLALA-PASSAGP 10 20 30 40 90 100 110 120 130 140 pF1KE0 IVISSQYPGQANRTAPGPMLRVTSLDTEVLTIKNLVDAHEAPPTLIEERRDFCIKVSPAE : :: . .::: . . . . . . . .: : : . .. : CCDS34 GPGLSLGPGPSFGFSPGP---TPTPEPTTSGLAGGAASHGPSPF----PRPWAPHALPFW 50 60 70 80 90 150 160 170 180 190 200 pF1KE0 DTPATLSADLAHFSENPILYLLLPLIFVNKCSFGCKVELEVLKGLMQSPQPMLLGLLGQF ::: :. : : . .: : :: :... . . .. : ::. : :: CCDS34 DTP--LNHGLNVFVGAALCITMLGL--------GCTVDVNHFGAHVRRPVGALLAALCQF 100 110 120 130 140 210 220 230 240 250 260 pF1KE0 LVMPLYAFLMAKVFMLPKALALGLIITCSSPGGGGSYLFSLLLGGDVTLAISMTFLSTVA ..:: :::.: .: : .. :..... :::. : :.:::. ::..:.: ::. ::. CCDS34 GLLPLLAFLLALAFKLDEVAAVAVLLCGCCPGGNLSNLMSLLVDGDMNLSIIMTISSTLL 150 160 170 180 190 200 270 280 290 300 310 320 pF1KE0 ATGFLPLSSAIYS-RLLSIHETLHVPISKILGTLLFIAIPIAVGVLIKSKLPKFSQLLLQ : ..:: ::: .. . .:.. . :: :::..::.:. : . .. ... CCDS34 ALVLMPLCLWIYSWAWINTPIVQLLPLGTVTLTLCSTLIPIGLGVFIRYKYSRVADYIVK 210 220 230 240 250 260 330 340 350 360 370 380 pF1KE0 VVKPFSFVLLLGGLFL--AYRMGVFILAGIRLPIVLVGITVPLVGLLVGYCLATCLKLPV : . .:... : ::. . .: .::.: . ...: .::.: :: ::: ..:: CCDS34 V-SLWSLLVTLVVLFIMTGTMLGPELLASIPAAVYVIAIFMPLAGYASGYGLATLFHLPP 270 280 290 300 310 320 390 400 410 420 430 440 pF1KE0 AQRRTVSIEVGVQNSLLALAMLQLSLRRLQADYASQAPFIVALSGTSEMLALVIGHFIYS .::: .:.: :: : :.:.:.. . :.. :: ..: .:. . .:. CCDS34 NCKRTVCLETGSQNVQLCTAILKLAFPPQFIGSMYMFPLLYALFQSAEAGIFVLIYKMYG 330 340 350 360 370 380 pF1KE0 SLFPVP : CCDS34 SEMLHKRDPLDEDEDTDISYKKLKEEEMADTSYGTVKAENIIMMETAQTSL 390 400 410 420 430 448 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 08:11:15 2016 done: Thu Nov 3 08:11:15 2016 Total Scan time: 3.330 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]