FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0450, 448 aa 1>>>pF1KE0450 448 - 448 aa - 448 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2058+/-0.000368; mu= 19.2406+/- 0.023 mean_var=85.5188+/-18.204, 0's: 0 Z-trim(114.4): 22 B-trim: 1175 in 1/50 Lambda= 0.138689 statistics sampled from 24285 (24303) to 24285 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.644), E-opt: 0.2 (0.285), width: 16 Scan time: 9.470 The best scores are: opt bits E(85289) NP_001135863 (OMIM: 312090) P3 protein isoform 2 p ( 448) 2871 584.5 1.9e-166 XP_006724911 (OMIM: 312090) PREDICTED: P3 protein ( 541) 2871 584.6 2.2e-166 XP_011529503 (OMIM: 312090) PREDICTED: P3 protein ( 477) 2083 426.9 5.8e-119 NP_001135864 (OMIM: 312090) P3 protein isoform 1 p ( 477) 2083 426.9 5.8e-119 NP_062822 (OMIM: 312090) P3 protein isoform 1 prec ( 477) 2083 426.9 5.8e-119 XP_005277970 (OMIM: 312090) PREDICTED: P3 protein ( 532) 2083 426.9 6.3e-119 XP_011529502 (OMIM: 312090) PREDICTED: P3 protein ( 532) 2083 426.9 6.3e-119 XP_006724910 (OMIM: 312090) PREDICTED: P3 protein ( 570) 2083 426.9 6.6e-119 NP_932069 (OMIM: 613366) solute carrier family 10 ( 377) 452 100.4 8.5e-21 NP_003040 (OMIM: 182396) sodium/bile acid cotransp ( 349) 438 97.6 5.6e-20 NP_000443 (OMIM: 601295,613291) ileal sodium/bile ( 348) 434 96.8 9.7e-20 >>NP_001135863 (OMIM: 312090) P3 protein isoform 2 precu (448 aa) initn: 2871 init1: 2871 opt: 2871 Z-score: 3109.2 bits: 584.5 E(85289): 1.9e-166 Smith-Waterman score: 2871; 100.0% identity (100.0% similar) in 448 aa overlap (1-448:1-448) 10 20 30 40 50 60 pF1KE0 MVLMQDKGSSQQWPGLGGEGGGTGPLSMLRAALLLISLPWGAQGTASTSLSTAGGHTVPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MVLMQDKGSSQQWPGLGGEGGGTGPLSMLRAALLLISLPWGAQGTASTSLSTAGGHTVPP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 TGGRYLSIGDGSVMEFEFPEDSEGIIVISSQYPGQANRTAPGPMLRVTSLDTEVLTIKNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TGGRYLSIGDGSVMEFEFPEDSEGIIVISSQYPGQANRTAPGPMLRVTSLDTEVLTIKNL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 VDAHEAPPTLIEERRDFCIKVSPAEDTPATLSADLAHFSENPILYLLLPLIFVNKCSFGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VDAHEAPPTLIEERRDFCIKVSPAEDTPATLSADLAHFSENPILYLLLPLIFVNKCSFGC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 KVELEVLKGLMQSPQPMLLGLLGQFLVMPLYAFLMAKVFMLPKALALGLIITCSSPGGGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KVELEVLKGLMQSPQPMLLGLLGQFLVMPLYAFLMAKVFMLPKALALGLIITCSSPGGGG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 SYLFSLLLGGDVTLAISMTFLSTVAATGFLPLSSAIYSRLLSIHETLHVPISKILGTLLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SYLFSLLLGGDVTLAISMTFLSTVAATGFLPLSSAIYSRLLSIHETLHVPISKILGTLLF 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 IAIPIAVGVLIKSKLPKFSQLLLQVVKPFSFVLLLGGLFLAYRMGVFILAGIRLPIVLVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IAIPIAVGVLIKSKLPKFSQLLLQVVKPFSFVLLLGGLFLAYRMGVFILAGIRLPIVLVG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 ITVPLVGLLVGYCLATCLKLPVAQRRTVSIEVGVQNSLLALAMLQLSLRRLQADYASQAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ITVPLVGLLVGYCLATCLKLPVAQRRTVSIEVGVQNSLLALAMLQLSLRRLQADYASQAP 370 380 390 400 410 420 430 440 pF1KE0 FIVALSGTSEMLALVIGHFIYSSLFPVP :::::::::::::::::::::::::::: NP_001 FIVALSGTSEMLALVIGHFIYSSLFPVP 430 440 >>XP_006724911 (OMIM: 312090) PREDICTED: P3 protein isof (541 aa) initn: 2871 init1: 2871 opt: 2871 Z-score: 3108.1 bits: 584.6 E(85289): 2.2e-166 Smith-Waterman score: 2871; 100.0% identity (100.0% similar) in 448 aa overlap (1-448:94-541) 10 20 30 pF1KE0 MVLMQDKGSSQQWPGLGGEGGGTGPLSMLR :::::::::::::::::::::::::::::: XP_006 PFSGQPNSTSGDVLLSRRGPGHAIRPPGRAMVLMQDKGSSQQWPGLGGEGGGTGPLSMLR 70 80 90 100 110 120 40 50 60 70 80 90 pF1KE0 AALLLISLPWGAQGTASTSLSTAGGHTVPPTGGRYLSIGDGSVMEFEFPEDSEGIIVISS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 AALLLISLPWGAQGTASTSLSTAGGHTVPPTGGRYLSIGDGSVMEFEFPEDSEGIIVISS 130 140 150 160 170 180 100 110 120 130 140 150 pF1KE0 QYPGQANRTAPGPMLRVTSLDTEVLTIKNLVDAHEAPPTLIEERRDFCIKVSPAEDTPAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QYPGQANRTAPGPMLRVTSLDTEVLTIKNLVDAHEAPPTLIEERRDFCIKVSPAEDTPAT 190 200 210 220 230 240 160 170 180 190 200 210 pF1KE0 LSADLAHFSENPILYLLLPLIFVNKCSFGCKVELEVLKGLMQSPQPMLLGLLGQFLVMPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LSADLAHFSENPILYLLLPLIFVNKCSFGCKVELEVLKGLMQSPQPMLLGLLGQFLVMPL 250 260 270 280 290 300 220 230 240 250 260 270 pF1KE0 YAFLMAKVFMLPKALALGLIITCSSPGGGGSYLFSLLLGGDVTLAISMTFLSTVAATGFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YAFLMAKVFMLPKALALGLIITCSSPGGGGSYLFSLLLGGDVTLAISMTFLSTVAATGFL 310 320 330 340 350 360 280 290 300 310 320 330 pF1KE0 PLSSAIYSRLLSIHETLHVPISKILGTLLFIAIPIAVGVLIKSKLPKFSQLLLQVVKPFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PLSSAIYSRLLSIHETLHVPISKILGTLLFIAIPIAVGVLIKSKLPKFSQLLLQVVKPFS 370 380 390 400 410 420 340 350 360 370 380 390 pF1KE0 FVLLLGGLFLAYRMGVFILAGIRLPIVLVGITVPLVGLLVGYCLATCLKLPVAQRRTVSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 FVLLLGGLFLAYRMGVFILAGIRLPIVLVGITVPLVGLLVGYCLATCLKLPVAQRRTVSI 430 440 450 460 470 480 400 410 420 430 440 pF1KE0 EVGVQNSLLALAMLQLSLRRLQADYASQAPFIVALSGTSEMLALVIGHFIYSSLFPVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EVGVQNSLLALAMLQLSLRRLQADYASQAPFIVALSGTSEMLALVIGHFIYSSLFPVP 490 500 510 520 530 540 >>XP_011529503 (OMIM: 312090) PREDICTED: P3 protein isof (477 aa) initn: 2083 init1: 2083 opt: 2083 Z-score: 2256.7 bits: 426.9 E(85289): 5.8e-119 Smith-Waterman score: 2803; 93.9% identity (93.9% similar) in 477 aa overlap (1-448:1-477) 10 20 30 40 50 60 pF1KE0 MVLMQDKGSSQQWPGLGGEGGGTGPLSMLRAALLLISLPWGAQGTASTSLSTAGGHTVPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MVLMQDKGSSQQWPGLGGEGGGTGPLSMLRAALLLISLPWGAQGTASTSLSTAGGHTVPP 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 TGGRYLSIGDGSVMEFEFPEDSEGIIVISSQYPGQANRTAPGPMLRVTSLDTEVLTIKN- ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TGGRYLSIGDGSVMEFEFPEDSEGIIVISSQYPGQANRTAPGPMLRVTSLDTEVLTIKNV 70 80 90 100 110 120 120 130 140 150 pF1KE0 ----------------------------LVDAHEAPPTLIEERRDFCIKVSPAEDTPATL :::::::::::::::::::::::::::::::: XP_011 SAITWGGGGGFVVSIHSGLAGLAPLHIQLVDAHEAPPTLIEERRDFCIKVSPAEDTPATL 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE0 SADLAHFSENPILYLLLPLIFVNKCSFGCKVELEVLKGLMQSPQPMLLGLLGQFLVMPLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SADLAHFSENPILYLLLPLIFVNKCSFGCKVELEVLKGLMQSPQPMLLGLLGQFLVMPLY 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE0 AFLMAKVFMLPKALALGLIITCSSPGGGGSYLFSLLLGGDVTLAISMTFLSTVAATGFLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AFLMAKVFMLPKALALGLIITCSSPGGGGSYLFSLLLGGDVTLAISMTFLSTVAATGFLP 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE0 LSSAIYSRLLSIHETLHVPISKILGTLLFIAIPIAVGVLIKSKLPKFSQLLLQVVKPFSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSSAIYSRLLSIHETLHVPISKILGTLLFIAIPIAVGVLIKSKLPKFSQLLLQVVKPFSF 310 320 330 340 350 360 340 350 360 370 380 390 pF1KE0 VLLLGGLFLAYRMGVFILAGIRLPIVLVGITVPLVGLLVGYCLATCLKLPVAQRRTVSIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLLLGGLFLAYRMGVFILAGIRLPIVLVGITVPLVGLLVGYCLATCLKLPVAQRRTVSIE 370 380 390 400 410 420 400 410 420 430 440 pF1KE0 VGVQNSLLALAMLQLSLRRLQADYASQAPFIVALSGTSEMLALVIGHFIYSSLFPVP ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VGVQNSLLALAMLQLSLRRLQADYASQAPFIVALSGTSEMLALVIGHFIYSSLFPVP 430 440 450 460 470 >>NP_001135864 (OMIM: 312090) P3 protein isoform 1 precu (477 aa) initn: 2083 init1: 2083 opt: 2083 Z-score: 2256.7 bits: 426.9 E(85289): 5.8e-119 Smith-Waterman score: 2803; 93.9% identity (93.9% similar) in 477 aa overlap (1-448:1-477) 10 20 30 40 50 60 pF1KE0 MVLMQDKGSSQQWPGLGGEGGGTGPLSMLRAALLLISLPWGAQGTASTSLSTAGGHTVPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MVLMQDKGSSQQWPGLGGEGGGTGPLSMLRAALLLISLPWGAQGTASTSLSTAGGHTVPP 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 TGGRYLSIGDGSVMEFEFPEDSEGIIVISSQYPGQANRTAPGPMLRVTSLDTEVLTIKN- ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TGGRYLSIGDGSVMEFEFPEDSEGIIVISSQYPGQANRTAPGPMLRVTSLDTEVLTIKNV 70 80 90 100 110 120 120 130 140 150 pF1KE0 ----------------------------LVDAHEAPPTLIEERRDFCIKVSPAEDTPATL :::::::::::::::::::::::::::::::: NP_001 SAITWGGGGGFVVSIHSGLAGLAPLHIQLVDAHEAPPTLIEERRDFCIKVSPAEDTPATL 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE0 SADLAHFSENPILYLLLPLIFVNKCSFGCKVELEVLKGLMQSPQPMLLGLLGQFLVMPLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SADLAHFSENPILYLLLPLIFVNKCSFGCKVELEVLKGLMQSPQPMLLGLLGQFLVMPLY 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE0 AFLMAKVFMLPKALALGLIITCSSPGGGGSYLFSLLLGGDVTLAISMTFLSTVAATGFLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AFLMAKVFMLPKALALGLIITCSSPGGGGSYLFSLLLGGDVTLAISMTFLSTVAATGFLP 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE0 LSSAIYSRLLSIHETLHVPISKILGTLLFIAIPIAVGVLIKSKLPKFSQLLLQVVKPFSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSSAIYSRLLSIHETLHVPISKILGTLLFIAIPIAVGVLIKSKLPKFSQLLLQVVKPFSF 310 320 330 340 350 360 340 350 360 370 380 390 pF1KE0 VLLLGGLFLAYRMGVFILAGIRLPIVLVGITVPLVGLLVGYCLATCLKLPVAQRRTVSIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VLLLGGLFLAYRMGVFILAGIRLPIVLVGITVPLVGLLVGYCLATCLKLPVAQRRTVSIE 370 380 390 400 410 420 400 410 420 430 440 pF1KE0 VGVQNSLLALAMLQLSLRRLQADYASQAPFIVALSGTSEMLALVIGHFIYSSLFPVP ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VGVQNSLLALAMLQLSLRRLQADYASQAPFIVALSGTSEMLALVIGHFIYSSLFPVP 430 440 450 460 470 >>NP_062822 (OMIM: 312090) P3 protein isoform 1 precurso (477 aa) initn: 2083 init1: 2083 opt: 2083 Z-score: 2256.7 bits: 426.9 E(85289): 5.8e-119 Smith-Waterman score: 2803; 93.9% identity (93.9% similar) in 477 aa overlap (1-448:1-477) 10 20 30 40 50 60 pF1KE0 MVLMQDKGSSQQWPGLGGEGGGTGPLSMLRAALLLISLPWGAQGTASTSLSTAGGHTVPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_062 MVLMQDKGSSQQWPGLGGEGGGTGPLSMLRAALLLISLPWGAQGTASTSLSTAGGHTVPP 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 TGGRYLSIGDGSVMEFEFPEDSEGIIVISSQYPGQANRTAPGPMLRVTSLDTEVLTIKN- ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_062 TGGRYLSIGDGSVMEFEFPEDSEGIIVISSQYPGQANRTAPGPMLRVTSLDTEVLTIKNV 70 80 90 100 110 120 120 130 140 150 pF1KE0 ----------------------------LVDAHEAPPTLIEERRDFCIKVSPAEDTPATL :::::::::::::::::::::::::::::::: NP_062 SAITWGGGGGFVVSIHSGLAGLAPLHIQLVDAHEAPPTLIEERRDFCIKVSPAEDTPATL 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE0 SADLAHFSENPILYLLLPLIFVNKCSFGCKVELEVLKGLMQSPQPMLLGLLGQFLVMPLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_062 SADLAHFSENPILYLLLPLIFVNKCSFGCKVELEVLKGLMQSPQPMLLGLLGQFLVMPLY 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE0 AFLMAKVFMLPKALALGLIITCSSPGGGGSYLFSLLLGGDVTLAISMTFLSTVAATGFLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_062 AFLMAKVFMLPKALALGLIITCSSPGGGGSYLFSLLLGGDVTLAISMTFLSTVAATGFLP 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE0 LSSAIYSRLLSIHETLHVPISKILGTLLFIAIPIAVGVLIKSKLPKFSQLLLQVVKPFSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_062 LSSAIYSRLLSIHETLHVPISKILGTLLFIAIPIAVGVLIKSKLPKFSQLLLQVVKPFSF 310 320 330 340 350 360 340 350 360 370 380 390 pF1KE0 VLLLGGLFLAYRMGVFILAGIRLPIVLVGITVPLVGLLVGYCLATCLKLPVAQRRTVSIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_062 VLLLGGLFLAYRMGVFILAGIRLPIVLVGITVPLVGLLVGYCLATCLKLPVAQRRTVSIE 370 380 390 400 410 420 400 410 420 430 440 pF1KE0 VGVQNSLLALAMLQLSLRRLQADYASQAPFIVALSGTSEMLALVIGHFIYSSLFPVP ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_062 VGVQNSLLALAMLQLSLRRLQADYASQAPFIVALSGTSEMLALVIGHFIYSSLFPVP 430 440 450 460 470 >>XP_005277970 (OMIM: 312090) PREDICTED: P3 protein isof (532 aa) initn: 2083 init1: 2083 opt: 2083 Z-score: 2256.1 bits: 426.9 E(85289): 6.3e-119 Smith-Waterman score: 2803; 93.9% identity (93.9% similar) in 477 aa overlap (1-448:56-532) 10 20 30 pF1KE0 MVLMQDKGSSQQWPGLGGEGGGTGPLSMLR :::::::::::::::::::::::::::::: XP_005 PFSGQPNSTSGDVLLSRRGPGHAIRPPGRAMVLMQDKGSSQQWPGLGGEGGGTGPLSMLR 30 40 50 60 70 80 40 50 60 70 80 90 pF1KE0 AALLLISLPWGAQGTASTSLSTAGGHTVPPTGGRYLSIGDGSVMEFEFPEDSEGIIVISS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AALLLISLPWGAQGTASTSLSTAGGHTVPPTGGRYLSIGDGSVMEFEFPEDSEGIIVISS 90 100 110 120 130 140 100 110 120 pF1KE0 QYPGQANRTAPGPMLRVTSLDTEVLTIKN-----------------------------LV ::::::::::::::::::::::::::::: :: XP_005 QYPGQANRTAPGPMLRVTSLDTEVLTIKNVSAITWGGGGGFVVSIHSGLAGLAPLHIQLV 150 160 170 180 190 200 130 140 150 160 170 180 pF1KE0 DAHEAPPTLIEERRDFCIKVSPAEDTPATLSADLAHFSENPILYLLLPLIFVNKCSFGCK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DAHEAPPTLIEERRDFCIKVSPAEDTPATLSADLAHFSENPILYLLLPLIFVNKCSFGCK 210 220 230 240 250 260 190 200 210 220 230 240 pF1KE0 VELEVLKGLMQSPQPMLLGLLGQFLVMPLYAFLMAKVFMLPKALALGLIITCSSPGGGGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VELEVLKGLMQSPQPMLLGLLGQFLVMPLYAFLMAKVFMLPKALALGLIITCSSPGGGGS 270 280 290 300 310 320 250 260 270 280 290 300 pF1KE0 YLFSLLLGGDVTLAISMTFLSTVAATGFLPLSSAIYSRLLSIHETLHVPISKILGTLLFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YLFSLLLGGDVTLAISMTFLSTVAATGFLPLSSAIYSRLLSIHETLHVPISKILGTLLFI 330 340 350 360 370 380 310 320 330 340 350 360 pF1KE0 AIPIAVGVLIKSKLPKFSQLLLQVVKPFSFVLLLGGLFLAYRMGVFILAGIRLPIVLVGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AIPIAVGVLIKSKLPKFSQLLLQVVKPFSFVLLLGGLFLAYRMGVFILAGIRLPIVLVGI 390 400 410 420 430 440 370 380 390 400 410 420 pF1KE0 TVPLVGLLVGYCLATCLKLPVAQRRTVSIEVGVQNSLLALAMLQLSLRRLQADYASQAPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TVPLVGLLVGYCLATCLKLPVAQRRTVSIEVGVQNSLLALAMLQLSLRRLQADYASQAPF 450 460 470 480 490 500 430 440 pF1KE0 IVALSGTSEMLALVIGHFIYSSLFPVP ::::::::::::::::::::::::::: XP_005 IVALSGTSEMLALVIGHFIYSSLFPVP 510 520 530 >>XP_011529502 (OMIM: 312090) PREDICTED: P3 protein isof (532 aa) initn: 2083 init1: 2083 opt: 2083 Z-score: 2256.1 bits: 426.9 E(85289): 6.3e-119 Smith-Waterman score: 2803; 93.9% identity (93.9% similar) in 477 aa overlap (1-448:56-532) 10 20 30 pF1KE0 MVLMQDKGSSQQWPGLGGEGGGTGPLSMLR :::::::::::::::::::::::::::::: XP_011 PFSGQPNSTSGDVLLSRRGPGHAIRPPGRAMVLMQDKGSSQQWPGLGGEGGGTGPLSMLR 30 40 50 60 70 80 40 50 60 70 80 90 pF1KE0 AALLLISLPWGAQGTASTSLSTAGGHTVPPTGGRYLSIGDGSVMEFEFPEDSEGIIVISS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AALLLISLPWGAQGTASTSLSTAGGHTVPPTGGRYLSIGDGSVMEFEFPEDSEGIIVISS 90 100 110 120 130 140 100 110 120 pF1KE0 QYPGQANRTAPGPMLRVTSLDTEVLTIKN-----------------------------LV ::::::::::::::::::::::::::::: :: XP_011 QYPGQANRTAPGPMLRVTSLDTEVLTIKNVSAITWGGGGGFVVSIHSGLAGLAPLHIQLV 150 160 170 180 190 200 130 140 150 160 170 180 pF1KE0 DAHEAPPTLIEERRDFCIKVSPAEDTPATLSADLAHFSENPILYLLLPLIFVNKCSFGCK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DAHEAPPTLIEERRDFCIKVSPAEDTPATLSADLAHFSENPILYLLLPLIFVNKCSFGCK 210 220 230 240 250 260 190 200 210 220 230 240 pF1KE0 VELEVLKGLMQSPQPMLLGLLGQFLVMPLYAFLMAKVFMLPKALALGLIITCSSPGGGGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VELEVLKGLMQSPQPMLLGLLGQFLVMPLYAFLMAKVFMLPKALALGLIITCSSPGGGGS 270 280 290 300 310 320 250 260 270 280 290 300 pF1KE0 YLFSLLLGGDVTLAISMTFLSTVAATGFLPLSSAIYSRLLSIHETLHVPISKILGTLLFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YLFSLLLGGDVTLAISMTFLSTVAATGFLPLSSAIYSRLLSIHETLHVPISKILGTLLFI 330 340 350 360 370 380 310 320 330 340 350 360 pF1KE0 AIPIAVGVLIKSKLPKFSQLLLQVVKPFSFVLLLGGLFLAYRMGVFILAGIRLPIVLVGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AIPIAVGVLIKSKLPKFSQLLLQVVKPFSFVLLLGGLFLAYRMGVFILAGIRLPIVLVGI 390 400 410 420 430 440 370 380 390 400 410 420 pF1KE0 TVPLVGLLVGYCLATCLKLPVAQRRTVSIEVGVQNSLLALAMLQLSLRRLQADYASQAPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TVPLVGLLVGYCLATCLKLPVAQRRTVSIEVGVQNSLLALAMLQLSLRRLQADYASQAPF 450 460 470 480 490 500 430 440 pF1KE0 IVALSGTSEMLALVIGHFIYSSLFPVP ::::::::::::::::::::::::::: XP_011 IVALSGTSEMLALVIGHFIYSSLFPVP 510 520 530 >>XP_006724910 (OMIM: 312090) PREDICTED: P3 protein isof (570 aa) initn: 2083 init1: 2083 opt: 2083 Z-score: 2255.7 bits: 426.9 E(85289): 6.6e-119 Smith-Waterman score: 2803; 93.9% identity (93.9% similar) in 477 aa overlap (1-448:94-570) 10 20 30 pF1KE0 MVLMQDKGSSQQWPGLGGEGGGTGPLSMLR :::::::::::::::::::::::::::::: XP_006 PFSGQPNSTSGDVLLSRRGPGHAIRPPGRAMVLMQDKGSSQQWPGLGGEGGGTGPLSMLR 70 80 90 100 110 120 40 50 60 70 80 90 pF1KE0 AALLLISLPWGAQGTASTSLSTAGGHTVPPTGGRYLSIGDGSVMEFEFPEDSEGIIVISS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 AALLLISLPWGAQGTASTSLSTAGGHTVPPTGGRYLSIGDGSVMEFEFPEDSEGIIVISS 130 140 150 160 170 180 100 110 120 pF1KE0 QYPGQANRTAPGPMLRVTSLDTEVLTIKN-----------------------------LV ::::::::::::::::::::::::::::: :: XP_006 QYPGQANRTAPGPMLRVTSLDTEVLTIKNVSAITWGGGGGFVVSIHSGLAGLAPLHIQLV 190 200 210 220 230 240 130 140 150 160 170 180 pF1KE0 DAHEAPPTLIEERRDFCIKVSPAEDTPATLSADLAHFSENPILYLLLPLIFVNKCSFGCK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DAHEAPPTLIEERRDFCIKVSPAEDTPATLSADLAHFSENPILYLLLPLIFVNKCSFGCK 250 260 270 280 290 300 190 200 210 220 230 240 pF1KE0 VELEVLKGLMQSPQPMLLGLLGQFLVMPLYAFLMAKVFMLPKALALGLIITCSSPGGGGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VELEVLKGLMQSPQPMLLGLLGQFLVMPLYAFLMAKVFMLPKALALGLIITCSSPGGGGS 310 320 330 340 350 360 250 260 270 280 290 300 pF1KE0 YLFSLLLGGDVTLAISMTFLSTVAATGFLPLSSAIYSRLLSIHETLHVPISKILGTLLFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YLFSLLLGGDVTLAISMTFLSTVAATGFLPLSSAIYSRLLSIHETLHVPISKILGTLLFI 370 380 390 400 410 420 310 320 330 340 350 360 pF1KE0 AIPIAVGVLIKSKLPKFSQLLLQVVKPFSFVLLLGGLFLAYRMGVFILAGIRLPIVLVGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 AIPIAVGVLIKSKLPKFSQLLLQVVKPFSFVLLLGGLFLAYRMGVFILAGIRLPIVLVGI 430 440 450 460 470 480 370 380 390 400 410 420 pF1KE0 TVPLVGLLVGYCLATCLKLPVAQRRTVSIEVGVQNSLLALAMLQLSLRRLQADYASQAPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TVPLVGLLVGYCLATCLKLPVAQRRTVSIEVGVQNSLLALAMLQLSLRRLQADYASQAPF 490 500 510 520 530 540 430 440 pF1KE0 IVALSGTSEMLALVIGHFIYSSLFPVP ::::::::::::::::::::::::::: XP_006 IVALSGTSEMLALVIGHFIYSSLFPVP 550 560 570 >>NP_932069 (OMIM: 613366) solute carrier family 10 memb (377 aa) initn: 454 init1: 357 opt: 452 Z-score: 494.4 bits: 100.4 E(85289): 8.5e-21 Smith-Waterman score: 452; 31.7% identity (63.5% similar) in 271 aa overlap (143-408:12-278) 120 130 140 150 160 170 pF1KE0 EVLTIKNLVDAHEAPPTLIEERRDFCIKVSPAEDTPATLSADLAHFSENPILYLLLPLIF ::... : . : .. ... .. .. NP_932 MRANCSSSSACPANSSEEELPVGLEVHGNLELVFTVVSTVM 10 20 30 40 180 190 200 210 220 230 pF1KE0 VN--KCSFGCKVELEVLKGLMQSPQPMLLGLLGQFLVMPLYAFLMAKVFMLPKALALGLI .. :.::.::.. : . .. : . .::: :: .::. :.:.: : : . :.... NP_932 MGLLMFSLGCSVEIRKLWSHIRRPWGIAVGLLCQFGLMPFTAYLLAISFSLKPVQAIAVL 50 60 70 80 90 100 240 250 260 270 280 290 pF1KE0 ITCSSPGGGGSYLFSLLLGGDVTLAISMTFLSTVAATGFLPLSSAIYSRLLSIHETLHVP : ::: : .:.. . ::. :.:::: ::::: :..:: .:. :....: .: NP_932 IMGCCPGGTISNIFTFWVDGDMDLSISMTTCSTVAALGMMPLCIYLYTWSWSLQQNLTIP 110 120 130 140 150 160 300 310 320 330 340 350 pF1KE0 ISKILGTLLFIAIPIAVGVLIKSKLPKFSQLLLQVVKPFSFVLLLGGLFLAYRMGVFILA ..: ::. ..::.: :: .. . :: :...:.. . :::: .. :: . NP_932 YQNIGITLVCLTIPVAFGVYVNYRWPKQSKIILKIGAVVGGVLLL----VVAVAGVVLAK 170 180 190 200 210 360 370 380 390 400 pF1KE0 GI---RLPIVLVGITVPLVGLLVGYCLATCLKLPVAQRRTVSIEVGVQNSLLALAMLQLS : . .. ... ::.: ..:. :: . . ::.:.:.:.:: . ..::::: NP_932 GSWNSDITLLTISFIFPLIGHVTGFLLALFTHQSWQRCRTISLETGAQNIQMCITMLQLS 220 230 240 250 260 270 410 420 430 440 pF1KE0 LRRLQADYASQAPFIVALSGTSEMLALVIGHFIYSSLFPVP . NP_932 FTAEHLVQMLSFPLAYGLFQLIDGFLIVAAYQTYKRRLKNKHGKKNSGCTEVCHTRKSTS 280 290 300 310 320 330 >>NP_003040 (OMIM: 182396) sodium/bile acid cotransporte (349 aa) initn: 409 init1: 271 opt: 438 Z-score: 479.7 bits: 97.6 E(85289): 5.6e-20 Smith-Waterman score: 438; 33.1% identity (65.7% similar) in 248 aa overlap (166-408:30-274) 140 150 160 170 180 190 pF1KE0 DFCIKVSPAEDTPATLSADLAHFSENPILYLLLPLIFVNKCSFGCKVELEVLKGLMQSPQ .:. ..: :.:: .:. .:. . .:. NP_003 MEAHNASAPFNFTLPPNFGKRPTDLALSVILVFMLFFIMLSLGCTMEFSKIKAHLWKPK 10 20 30 40 50 200 210 220 230 240 250 pF1KE0 PMLLGLLGQFLVMPLYAFLMAKVFMLPKALALGLIITCSSPGGGGSYLFSLLLGGDVTLA . ..:..:. .::: ::...::: : . ::.... ::::. : .::: . ::..:. NP_003 GLAIALVAQYGIMPLTAFVLGKVFRLKNIEALAILVCGCSPGGNLSNVFSLAMKGDMNLS 60 70 80 90 100 110 260 270 280 290 300 310 pF1KE0 ISMTFLSTVAATGFLPLSSAIYSRLLSIHETL-HVPISKILGTLLFIAIPIAVGVLIKSK : :: :: : :..:: :::: . . .:: . :. .:... :: ..:...::: NP_003 IVMTTCSTFCALGMMPLLLYIYSRGIYDGDLKDKVPYKGIVISLVLVLIPCTIGIVLKSK 120 130 140 150 160 170 320 330 340 350 360 370 pF1KE0 LPKFSQLLLQVVKPFSFVLLLGGLFL----AYRMGVFILAGIRLPIVLVGITVPLVGLLV : : . :.: ...:: .. . : .: :. .. .. .. .:..:.:. NP_003 RP---QYMRYVIKGGMIIILLCSVAVTVLSAINVGKSIMFAMTPLLIATSSLMPFIGFLL 180 190 200 210 220 230 380 390 400 410 420 430 pF1KE0 GYCLATCLKLPVAQRRTVSIEVGVQNSLLALAMLQLSLRRLQADYASQAPFIVALSGTSE :: :.. . : :::::.:.: :: : ..:.... NP_003 GYVLSALFCLNGRCRRTVSMETGCQNVQLCSTILNVAFPPEVIGPLFFFPLLYMIFQLGE 240 250 260 270 280 290 440 pF1KE0 MLALVIGHFIYSSLFPVP NP_003 GLLLIAIFWCYEKFKTPKDKTKMIYTAATTEETIPGALGNGTYKGEDCSPCTA 300 310 320 330 340 448 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 08:11:15 2016 done: Thu Nov 3 08:11:17 2016 Total Scan time: 9.470 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]