FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0473, 197 aa 1>>>pF1KE0473 197 - 197 aa - 197 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.7743+/-0.000946; mu= 0.6579+/- 0.058 mean_var=240.3979+/-47.944, 0's: 0 Z-trim(114.4): 34 B-trim: 10 in 1/51 Lambda= 0.082720 statistics sampled from 14948 (14981) to 14948 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.773), E-opt: 0.2 (0.46), width: 16 Scan time: 1.460 The best scores are: opt bits E(32554) CCDS11510.1 MYL4 gene_id:4635|Hs108|chr17 ( 197) 1315 168.5 2.4e-42 CCDS2746.1 MYL3 gene_id:4634|Hs108|chr3 ( 195) 1056 137.6 4.7e-33 CCDS2390.1 MYL1 gene_id:4632|Hs108|chr2 ( 194) 905 119.6 1.3e-27 CCDS8905.1 MYL6B gene_id:140465|Hs108|chr12 ( 208) 834 111.1 4.7e-25 CCDS8906.1 MYL6 gene_id:4637|Hs108|chr12 ( 151) 790 105.8 1.4e-23 CCDS31834.1 MYL6 gene_id:4637|Hs108|chr12 ( 151) 761 102.3 1.6e-22 CCDS2391.1 MYL1 gene_id:4632|Hs108|chr2 ( 150) 740 99.8 8.8e-22 >>CCDS11510.1 MYL4 gene_id:4635|Hs108|chr17 (197 aa) initn: 1315 init1: 1315 opt: 1315 Z-score: 873.9 bits: 168.5 E(32554): 2.4e-42 Smith-Waterman score: 1315; 100.0% identity (100.0% similar) in 197 aa overlap (1-197:1-197) 10 20 30 40 50 60 pF1KE0 MAPKKPEPKKEAAKPAPAPAPAPAPAPAPAPEAPKEPAFDPKSVKIDFTADQIEEFKEAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 MAPKKPEPKKEAAKPAPAPAPAPAPAPAPAPEAPKEPAFDPKSVKIDFTADQIEEFKEAF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 SLFDRTPTGEMKITYGQCGDVLRALGQNPTNAEVLRVLGKPKPEEMNVKMLDFETFLPIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 SLFDRTPTGEMKITYGQCGDVLRALGQNPTNAEVLRVLGKPKPEEMNVKMLDFETFLPIL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 QHISRNKEQGTYEDFVEGLRVFDKESNGTVMGAELRHVLATLGEKMTEAEVEQLLAGQED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 QHISRNKEQGTYEDFVEGLRVFDKESNGTVMGAELRHVLATLGEKMTEAEVEQLLAGQED 130 140 150 160 170 180 190 pF1KE0 ANGCINYEAFVKHIMSG ::::::::::::::::: CCDS11 ANGCINYEAFVKHIMSG 190 >>CCDS2746.1 MYL3 gene_id:4634|Hs108|chr3 (195 aa) initn: 987 init1: 987 opt: 1056 Z-score: 706.9 bits: 137.6 E(32554): 4.7e-33 Smith-Waterman score: 1056; 80.6% identity (90.8% similar) in 196 aa overlap (1-196:1-194) 10 20 30 40 50 60 pF1KE0 MAPKKPEPKKEAAKPAPAPAPAPAPAPAPAPEAPKEPAFDPKSVKIDFTADQIEEFKEAF ::::::::::. :: :: :::::: : : :: ::: :: ...::.:: .::::::::: CCDS27 MAPKKPEPKKDDAKAAPKAAPAPAP-P-PEPERPKEVEFDASKIKIEFTPEQIEEFKEAF 10 20 30 40 50 70 80 90 100 110 120 pF1KE0 SLFDRTPTGEMKITYGQCGDVLRALGQNPTNAEVLRVLGKPKPEEMNVKMLDFETFLPIL :::::: :::::::::::::::::::::.::::::::::. ::.:.::.:::::::.: CCDS27 MLFDRTPKCEMKITYGQCGDVLRALGQNPTQAEVLRVLGKPRQEELNTKMMDFETFLPML 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE0 QHISRNKEQGTYEDFVEGLRVFDKESNGTVMGAELRHVLATLGEKMTEAEVEQLLAGQED ::::.::. ::::::::::::::::.::::::::::::::::::..:: :::.:.::::: CCDS27 QHISKNKDTGTYEDFVEGLRVFDKEGNGTVMGAELRHVLATLGERLTEDEVEKLMAGQED 120 130 140 150 160 170 190 pF1KE0 ANGCINYEAFVKHIMSG .::::::::::::::: CCDS27 SNGCINYEAFVKHIMSS 180 190 >>CCDS2390.1 MYL1 gene_id:4632|Hs108|chr2 (194 aa) initn: 721 init1: 721 opt: 905 Z-score: 609.5 bits: 119.6 E(32554): 1.3e-27 Smith-Waterman score: 905; 71.9% identity (85.2% similar) in 196 aa overlap (1-196:1-193) 10 20 30 40 50 60 pF1KE0 MAPKKPEPKKEAAKPAPAPAPAPAPAPAPAPEAPKEPAFDPKSVKIDFTADQIEEFKEAF ::::: . :: .: : :::::::::::::: ::: .: ...::.:. .: .:::::: CCDS23 MAPKK-DVKKPVAAAAAAPAPAPAPAPAPAPAKPKEEKIDLSAIKIEFSKEQQDEFKEAF 10 20 30 40 50 70 80 90 100 110 120 pF1KE0 SLFDRTPTGEMKITYGQCGDVLRALGQNPTNAEVLRVLGKPKPEEMNVKMLDFETFLPIL :::: ::. ::: .: :::::::: ::::::: .:::.:. ::.:.: ..:: :::.. CCDS23 LLFDR--TGDSKITLSQVGDVLRALGTNPTNAEVRKVLGNPSNEELNAKKIEFEQFLPMM 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE0 QHISRNKEQGTYEDFVEGLRVFDKESNGTVMGAELRHVLATLGEKMTEAEVEQLLAGQED : :: ::.:.:::::::::::::::.:::::::::::::::::::: : ::: :.::::: CCDS23 QAISNNKDQATYEDFVEGLRVFDKEGNGTVMGAELRHVLATLGEKMKEEEVEALMAGQED 120 130 140 150 160 170 190 pF1KE0 ANGCINYEAFVKHIMSG .::::::::::::::: CCDS23 SNGCINYEAFVKHIMSI 180 190 >>CCDS8905.1 MYL6B gene_id:140465|Hs108|chr12 (208 aa) initn: 982 init1: 649 opt: 834 Z-score: 563.3 bits: 111.1 E(32554): 4.7e-25 Smith-Waterman score: 834; 65.8% identity (83.4% similar) in 199 aa overlap (3-196:12-207) 10 20 30 40 pF1KE0 MAPKKPEPKKEAAKPAPAPAPAPAPAPA-PA-PEAPK---EPAFDPKSVKI : : .: ::::: : :: :: . : :: :.::. :: : ..: : CCDS89 MPPKKDVPVKKPAGPSISKPAAKPAAAGAP-PAKTKAEPAVPQAPQKTQEPPVDLSKVVI 10 20 30 40 50 50 60 70 80 90 100 pF1KE0 DFTADQIEEFKEAFSLFDRTPTGEMKITYGQCGDVLRALGQNPTNAEVLRVLGKPKPEEM .:. ::.::::::: ::::. :. :: :.:::::.:::::::::::::.:::.:: .:. CCDS89 EFNKDQLEEFKEAFELFDRV--GDGKILYSQCGDVMRALGQNPTNAEVLKVLGNPKSDEL 60 70 80 90 100 110 110 120 130 140 150 160 pF1KE0 NVKMLDFETFLPILQHISRNKEQGTYEDFVEGLRVFDKESNGTVMGAELRHVLATLGEKM . . .:::::::.:: ...:. ::::::..::.::::::.:: ::::::::::.:::::: CCDS89 KSRRVDFETFLPMLQAVAKNRGQGTYEDYLEGFRVFDKEGNGKVMGAELRHVLTTLGEKM 120 130 140 150 160 170 170 180 190 pF1KE0 TEAEVEQLLAGQEDANGCINYEAFVKHIMSG :: ::: .:::.::.:::::::::.:::.: CCDS89 TEEEVETVLAGHEDSNGCINYEAFLKHILSV 180 190 200 >>CCDS8906.1 MYL6 gene_id:4637|Hs108|chr12 (151 aa) initn: 704 init1: 704 opt: 790 Z-score: 536.8 bits: 105.8 E(32554): 1.4e-23 Smith-Waterman score: 790; 77.5% identity (92.7% similar) in 151 aa overlap (47-197:3-151) 20 30 40 50 60 70 pF1KE0 PAPAPAPAPAPAPAPEAPKEPAFDPKSVKIDFTADQIEEFKEAFSLFDRTPTGEMKITYG ::: :: ::::::.::::: :. :: :. CCDS89 MCDFTEDQTAEFKEAFQLFDRT--GDGKILYS 10 20 30 80 90 100 110 120 130 pF1KE0 QCGDVLRALGQNPTNAEVLRVLGKPKPEEMNVKMLDFETFLPILQHISRNKEQGTYEDFV :::::.:::::::::::::.:::.:: .:::::.:::: :::.:: ...::.::::::.: CCDS89 QCGDVMRALGQNPTNAEVLKVLGNPKSDEMNVKVLDFEHFLPMLQTVAKNKDQGTYEDYV 40 50 60 70 80 90 140 150 160 170 180 190 pF1KE0 EGLRVFDKESNGTVMGAELRHVLATLGEKMTEAEVEQLLAGQEDANGCINYEAFVKHIMS :::::::::.::::::::.::::.:::::::: :::.:.::.::.::::::::::.::.: CCDS89 EGLRVFDKEGNGTVMGAEIRHVLVTLGEKMTEEEVEMLVAGHEDSNGCINYEAFVRHILS 100 110 120 130 140 150 pF1KE0 G : CCDS89 G >>CCDS31834.1 MYL6 gene_id:4637|Hs108|chr12 (151 aa) initn: 832 init1: 675 opt: 761 Z-score: 518.1 bits: 102.3 E(32554): 1.6e-22 Smith-Waterman score: 761; 74.2% identity (91.4% similar) in 151 aa overlap (47-197:3-151) 20 30 40 50 60 70 pF1KE0 PAPAPAPAPAPAPAPEAPKEPAFDPKSVKIDFTADQIEEFKEAFSLFDRTPTGEMKITYG ::: :: ::::::.::::: :. :: :. CCDS31 MCDFTEDQTAEFKEAFQLFDRT--GDGKILYS 10 20 30 80 90 100 110 120 130 pF1KE0 QCGDVLRALGQNPTNAEVLRVLGKPKPEEMNVKMLDFETFLPILQHISRNKEQGTYEDFV :::::.:::::::::::::.:::.:: .:::::.:::: :::.:: ...::.::::::.: CCDS31 QCGDVMRALGQNPTNAEVLKVLGNPKSDEMNVKVLDFEHFLPMLQTVAKNKDQGTYEDYV 40 50 60 70 80 90 140 150 160 170 180 190 pF1KE0 EGLRVFDKESNGTVMGAELRHVLATLGEKMTEAEVEQLLAGQEDANGCINYEAFVKHIMS :::::::::.::::::::.::::.:::::::: :::.:.::.::.::::::: .:. ... CCDS31 EGLRVFDKEGNGTVMGAEIRHVLVTLGEKMTEEEVEMLVAGHEDSNGCINYEELVRMVLN 100 110 120 130 140 150 pF1KE0 G : CCDS31 G >>CCDS2391.1 MYL1 gene_id:4632|Hs108|chr2 (150 aa) initn: 654 init1: 654 opt: 740 Z-score: 504.5 bits: 99.8 E(32554): 8.8e-22 Smith-Waterman score: 740; 76.2% identity (88.7% similar) in 151 aa overlap (46-196:1-149) 20 30 40 50 60 70 pF1KE0 APAPAPAPAPAPAPAPEAPKEPAFDPKSVKIDFTADQIEEFKEAFSLFDRTPTGEMKITY ..:.:::: :::::: :::: ::. ::: CCDS23 MSFSADQIAEFKEAFLLFDR--TGDSKITL 10 20 80 90 100 110 120 130 pF1KE0 GQCGDVLRALGQNPTNAEVLRVLGKPKPEEMNVKMLDFETFLPILQHISRNKEQGTYEDF .: :::::::: ::::::: .:::.:. ::.:.: ..:: :::..: :: ::.:.::::: CCDS23 SQVGDVLRALGTNPTNAEVRKVLGNPSNEELNAKKIEFEQFLPMMQAISNNKDQATYEDF 30 40 50 60 70 80 140 150 160 170 180 190 pF1KE0 VEGLRVFDKESNGTVMGAELRHVLATLGEKMTEAEVEQLLAGQEDANGCINYEAFVKHIM ::::::::::.:::::::::::::::::::: : ::: :.:::::.:::::::::::::: CCDS23 VEGLRVFDKEGNGTVMGAELRHVLATLGEKMKEEEVEALMAGQEDSNGCINYEAFVKHIM 90 100 110 120 130 140 pF1KE0 SG : CCDS23 SI 150 197 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 06:01:43 2016 done: Thu Nov 3 06:01:43 2016 Total Scan time: 1.460 Total Display time: -0.030 Function used was FASTA [36.3.4 Apr, 2011]