FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0477, 305 aa 1>>>pF1KE0477 305 - 305 aa - 305 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.8537+/-0.00085; mu= 12.0553+/- 0.051 mean_var=60.7481+/-12.367, 0's: 0 Z-trim(105.8): 22 B-trim: 0 in 0/50 Lambda= 0.164554 statistics sampled from 8593 (8599) to 8593 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.641), E-opt: 0.2 (0.264), width: 16 Scan time: 2.440 The best scores are: opt bits E(32554) CCDS3668.2 PPA2 gene_id:27068|Hs108|chr4 ( 305) 2074 500.8 5.3e-142 CCDS3667.1 PPA2 gene_id:27068|Hs108|chr4 ( 334) 1084 265.8 3.2e-71 CCDS3669.2 PPA2 gene_id:27068|Hs108|chr4 ( 232) 1077 264.1 7.2e-71 CCDS34043.1 PPA2 gene_id:27068|Hs108|chr4 ( 168) 801 198.6 2.8e-51 CCDS7299.1 PPA1 gene_id:5464|Hs108|chr10 ( 289) 642 160.9 1.1e-39 >>CCDS3668.2 PPA2 gene_id:27068|Hs108|chr4 (305 aa) initn: 2074 init1: 2074 opt: 2074 Z-score: 2662.9 bits: 500.8 E(32554): 5.3e-142 Smith-Waterman score: 2074; 100.0% identity (100.0% similar) in 305 aa overlap (1-305:1-305) 10 20 30 40 50 60 pF1KE0 MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS36 MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 SPFHDIPLKVNSKEENGIPMKKARNDEYENLFNMIVEIPRWTNAKMEIATKEPMNPIKQY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS36 SPFHDIPLKVNSKEENGIPMKKARNDEYENLFNMIVEIPRWTNAKMEIATKEPMNPIKQY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 VKDGKLRYVANIFPYKGYIWNYGTLPQILSCGEVIHVKILGILALIDEGETDWKLIAINA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS36 VKDGKLRYVANIFPYKGYIWNYGTLPQILSCGEVIHVKILGILALIDEGETDWKLIAINA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 NDPEASKFHDIDDVKKFKPGYLEATLNWFRLYKVPDGKPENQFAFNGEFKNKAFALEVIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS36 NDPEASKFHDIDDVKKFKPGYLEATLNWFRLYKVPDGKPENQFAFNGEFKNKAFALEVIK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 STHQCWKALLMKKCNGGAINCTNVQISDSPFRCTQEEARSLVESVSSSPNKESNEEEQVW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS36 STHQCWKALLMKKCNGGAINCTNVQISDSPFRCTQEEARSLVESVSSSPNKESNEEEQVW 250 260 270 280 290 300 pF1KE0 HFLGK ::::: CCDS36 HFLGK >>CCDS3667.1 PPA2 gene_id:27068|Hs108|chr4 (334 aa) initn: 1077 init1: 1077 opt: 1084 Z-score: 1392.1 bits: 265.8 E(32554): 3.2e-71 Smith-Waterman score: 2006; 91.3% identity (91.3% similar) in 334 aa overlap (1-305:1-334) 10 20 30 40 50 60 pF1KE0 MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS36 MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 SPFHDIPLKVNSKEENGIPMKKARNDEYENLFNMIVEIPRWTNAKMEIATKEPMNPIKQY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS36 SPFHDIPLKVNSKEENGIPMKKARNDEYENLFNMIVEIPRWTNAKMEIATKEPMNPIKQY 70 80 90 100 110 120 130 140 150 pF1KE0 VKDGKLRYVANIFPYKGYIWNYGTLPQ-----------------------------ILSC ::::::::::::::::::::::::::: :::: CCDS36 VKDGKLRYVANIFPYKGYIWNYGTLPQTWEDPHEKDKSTNCFGDNDPIDVCEIGSKILSC 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE0 GEVIHVKILGILALIDEGETDWKLIAINANDPEASKFHDIDDVKKFKPGYLEATLNWFRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS36 GEVIHVKILGILALIDEGETDWKLIAINANDPEASKFHDIDDVKKFKPGYLEATLNWFRL 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE0 YKVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISDSPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS36 YKVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISDSPF 250 260 270 280 290 300 280 290 300 pF1KE0 RCTQEEARSLVESVSSSPNKESNEEEQVWHFLGK :::::::::::::::::::::::::::::::::: CCDS36 RCTQEEARSLVESVSSSPNKESNEEEQVWHFLGK 310 320 330 >>CCDS3669.2 PPA2 gene_id:27068|Hs108|chr4 (232 aa) initn: 1077 init1: 1077 opt: 1077 Z-score: 1385.8 bits: 264.1 E(32554): 7.2e-71 Smith-Waterman score: 1413; 76.1% identity (76.1% similar) in 305 aa overlap (1-305:1-232) 10 20 30 40 50 60 pF1KE0 MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS36 MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 SPFHDIPLKVNSKEENGIPMKKARNDEYENLFNMIVEIPRWTNAKMEIATKEPMNPIKQY :::::::::::::: CCDS36 SPFHDIPLKVNSKE---------------------------------------------- 70 130 140 150 160 170 180 pF1KE0 VKDGKLRYVANIFPYKGYIWNYGTLPQILSCGEVIHVKILGILALIDEGETDWKLIAINA ::::::::::::::::::::::::::::::::: CCDS36 ---------------------------ILSCGEVIHVKILGILALIDEGETDWKLIAINA 80 90 100 190 200 210 220 230 240 pF1KE0 NDPEASKFHDIDDVKKFKPGYLEATLNWFRLYKVPDGKPENQFAFNGEFKNKAFALEVIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS36 NDPEASKFHDIDDVKKFKPGYLEATLNWFRLYKVPDGKPENQFAFNGEFKNKAFALEVIK 110 120 130 140 150 160 250 260 270 280 290 300 pF1KE0 STHQCWKALLMKKCNGGAINCTNVQISDSPFRCTQEEARSLVESVSSSPNKESNEEEQVW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS36 STHQCWKALLMKKCNGGAINCTNVQISDSPFRCTQEEARSLVESVSSSPNKESNEEEQVW 170 180 190 200 210 220 pF1KE0 HFLGK ::::: CCDS36 HFLGK 230 >>CCDS34043.1 PPA2 gene_id:27068|Hs108|chr4 (168 aa) initn: 801 init1: 801 opt: 801 Z-score: 1034.1 bits: 198.6 E(32554): 2.8e-51 Smith-Waterman score: 854; 54.8% identity (55.1% similar) in 305 aa overlap (1-305:1-168) 10 20 30 40 50 60 pF1KE0 MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYI :::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFF-------- 10 20 30 40 50 70 80 90 100 110 120 pF1KE0 SPFHDIPLKVNSKEENGIPMKKARNDEYENLFNMIVEIPRWTNAKMEIATKEPMNPIKQY CCDS34 ------------------------------------------------------------ 130 140 150 160 170 180 pF1KE0 VKDGKLRYVANIFPYKGYIWNYGTLPQILSCGEVIHVKILGILALIDEGETDWKLIAINA CCDS34 ------------------------------------------------------------ 190 200 210 220 230 240 pF1KE0 NDPEASKFHDIDDVKKFKPGYLEATLNWFRLYKVPDGKPENQFAFNGEFKNKAFALEVIK .:::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 ---------NIDDVKKFKPGYLEATLNWFRLYKVPDGKPENQFAFNGEFKNKAFALEVIK 60 70 80 90 100 250 260 270 280 290 300 pF1KE0 STHQCWKALLMKKCNGGAINCTNVQISDSPFRCTQEEARSLVESVSSSPNKESNEEEQVW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 STHQCWKALLMKKCNGGAINCTNVQISDSPFRCTQEEARSLVESVSSSPNKESNEEEQVW 110 120 130 140 150 160 pF1KE0 HFLGK ::::: CCDS34 HFLGK >>CCDS7299.1 PPA1 gene_id:5464|Hs108|chr10 (289 aa) initn: 1105 init1: 640 opt: 642 Z-score: 826.1 bits: 160.9 E(32554): 1.1e-39 Smith-Waterman score: 1031; 54.3% identity (74.2% similar) in 291 aa overlap (32-293:1-272) 10 20 30 40 50 60 pF1KE0 SALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYIS :. . ::::. : : .::.:.:: :.::: CCDS72 MSGFSTEERAAPFSLEYRVFLKNEKGQYIS 10 20 30 70 80 90 100 110 120 pF1KE0 PFHDIPLKVNSKEENGIPMKKARNDEYENLFNMIVEIPRWTNAKMEIATKEPMNPIKQYV ::::::. .. ...:.:.::.:::.:::::::::.:.::::: : CCDS72 PFHDIPIYAD-----------------KDVFHMVVEVPRWSNAKMEIATKDPLNPIKQDV 40 50 60 70 130 140 150 pF1KE0 KDGKLRYVANIFPYKGYIWNYGTLPQ--------------------ILSC---------G : ::::::::.:::::::::::..:: : : : CCDS72 KKGKLRYVANLFPYKGYIWNYGAIPQTWEDPGHNDKHTGCCGDNDPIDVCEIGSKVCARG 80 90 100 110 120 130 160 170 180 190 200 210 pF1KE0 EVIHVKILGILALIDEGETDWKLIAINANDPEASKFHDIDDVKKFKPGYLEATLNWFRLY :.: ::.:::::.:::::::::.::::..::.:....::.:::..::::::::..::: : CCDS72 EIIGVKVLGILAMIDEGETDWKVIAINVDDPDAANYNDINDVKRLKPGYLEATVDWFRRY 140 150 160 170 180 190 220 230 240 250 260 270 pF1KE0 KVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISDSPFR :::::::::.::::.:::.: ::...:::::. ::::. :: :: .:.: :. .:.:::. CCDS72 KVPDGKPENEFAFNAEFKDKDFAIDIIKSTHDHWKALVTKKTNGKGISCMNTTLSESPFK 200 210 220 230 240 250 280 290 300 pF1KE0 CTQEEARSLVESVSSSPNKESNEEEQVWHFLGK : . ::..:... : :: CCDS72 CDPDAARAIVDALP--PPCESACTVPTDVDKWFHHQKN 260 270 280 305 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 05:27:57 2016 done: Thu Nov 3 05:27:57 2016 Total Scan time: 2.440 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]