FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0501, 205 aa 1>>>pF1KE0501 205 - 205 aa - 205 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.3226+/-0.000736; mu= 13.1409+/- 0.045 mean_var=60.9220+/-12.148, 0's: 0 Z-trim(108.7): 18 B-trim: 233 in 1/53 Lambda= 0.164319 statistics sampled from 10376 (10392) to 10376 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.704), E-opt: 0.2 (0.319), width: 16 Scan time: 2.140 The best scores are: opt bits E(32554) CCDS13831.1 CRYBB2 gene_id:1415|Hs108|chr22 ( 205) 1442 349.9 6.6e-97 CCDS13830.1 CRYBB3 gene_id:1417|Hs108|chr22 ( 211) 838 206.7 8.6e-54 CCDS13840.1 CRYBB1 gene_id:1414|Hs108|chr22 ( 252) 805 198.9 2.3e-51 CCDS11249.1 CRYBA1 gene_id:1411|Hs108|chr17 ( 215) 579 145.3 2.7e-35 CCDS13841.1 CRYBA4 gene_id:1413|Hs108|chr22 ( 196) 512 129.4 1.5e-30 CCDS2429.1 CRYBA2 gene_id:1412|Hs108|chr2 ( 197) 478 121.3 4e-28 CCDS3275.1 CRYGS gene_id:1427|Hs108|chr3 ( 178) 406 104.2 5e-23 CCDS2380.1 CRYGB gene_id:1419|Hs108|chr2 ( 175) 398 102.3 1.8e-22 CCDS2379.1 CRYGC gene_id:1420|Hs108|chr2 ( 174) 388 100.0 9.4e-22 CCDS33367.1 CRYGA gene_id:1418|Hs108|chr2 ( 174) 380 98.1 3.5e-21 CCDS2378.1 CRYGD gene_id:1421|Hs108|chr2 ( 174) 348 90.5 6.7e-19 CCDS34506.1 AIM1 gene_id:202|Hs108|chr6 (1723) 321 84.5 4.2e-16 >>CCDS13831.1 CRYBB2 gene_id:1415|Hs108|chr22 (205 aa) initn: 1442 init1: 1442 opt: 1442 Z-score: 1853.2 bits: 349.9 E(32554): 6.6e-97 Smith-Waterman score: 1442; 100.0% identity (100.0% similar) in 205 aa overlap (1-205:1-205) 10 20 30 40 50 60 pF1KE0 MASDHQTQAGKPQSLNPKIIIFEQENFQGHSHELNGPCPNLKETGVEKAGSVLVQAGPWV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 MASDHQTQAGKPQSLNPKIIIFEQENFQGHSHELNGPCPNLKETGVEKAGSVLVQAGPWV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 GYEQANCKGEQFVFEKGEYPRWDSWTSSRRTDSLSSLRPIKVDSQEHKIILYENPNFTGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 GYEQANCKGEQFVFEKGEYPRWDSWTSSRRTDSLSSLRPIKVDSQEHKIILYENPNFTGK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 KMEIIDDDVPSFHAHGYQEKVSSVRVQSGTWVGYQYPGYRGLQYLLEKGDYKDSSDFGAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 KMEIIDDDVPSFHAHGYQEKVSSVRVQSGTWVGYQYPGYRGLQYLLEKGDYKDSSDFGAP 130 140 150 160 170 180 190 200 pF1KE0 HPQVQSVRRIRDMQWHQRGAFHPSN ::::::::::::::::::::::::: CCDS13 HPQVQSVRRIRDMQWHQRGAFHPSN 190 200 >>CCDS13830.1 CRYBB3 gene_id:1417|Hs108|chr22 (211 aa) initn: 965 init1: 805 opt: 838 Z-score: 1079.2 bits: 206.7 E(32554): 8.6e-54 Smith-Waterman score: 838; 53.8% identity (83.0% similar) in 212 aa overlap (1-205:1-211) 10 20 30 40 50 pF1KE0 MASDH----QTQAGKPQSL---NPKIIIFEQENFQGHSHELNGPCPNLKETGVEKAGSVL :: .: :. ::: .. . :.:..: :::::. ::.. ::.: .. .::.::. CCDS13 MAEQHGAPEQAAAGKSHGDLGGSYKVILYELENFQGKRCELSAECPSLTDSLLEKVGSIQ 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE0 VQAGPWVGYEQANCKGEQFVFEKGEYPRWDSWTSSRRTDSLSSLRPIKVDSQEHKIILYE :..:::...:. .:::::.:::.:::::.:..:: .::: ::::...:: .::. :.: CCDS13 VESGPWLAFESRAFRGEQFVLEKGDYPRWDAWSNSRDSDSLLSLRPLNIDSPHHKLHLFE 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE0 NPNFTGKKMEIIDDDVPSFHAHGYQEKVSSVRVQSGTWVGYQYPGYRGLQYLLEKGDYKD :: :.:.::::.::::::. :::.:..:.:::. .::::::..::::: ::..:.:.:. CCDS13 NPAFSGRKMEIVDDDVPSLWAHGFQDRVASVRAINGTWVGYEFPGYRGRQYVFERGEYRH 130 140 150 160 170 180 180 190 200 pF1KE0 SSDFGAPHPQVQSVRRIRDMQWHQRGAFHPSN ... : .::.::::::::..::.:: : ::. CCDS13 WNEWDASQPQLQSVRRIRDQKWHKRGRF-PSS 190 200 210 >>CCDS13840.1 CRYBB1 gene_id:1414|Hs108|chr22 (252 aa) initn: 934 init1: 788 opt: 805 Z-score: 1035.7 bits: 198.9 E(32554): 2.3e-51 Smith-Waterman score: 805; 55.9% identity (84.9% similar) in 186 aa overlap (16-201:58-243) 10 20 30 40 pF1KE0 MASDHQTQAGKPQSLNPKIIIFEQENFQGHSHELNGPCPNLKETG : ....:: :::::. :..: : :: . : CCDS13 PAGTSPSPGTTLAPTTVPITSAKAAELPPGNYRLVVFELENFQGRRAEFSGECSNLADRG 30 40 50 60 70 80 50 60 70 80 90 100 pF1KE0 VEKAGSVLVQAGPWVGYEQANCKGEQFVFEKGEYPRWDSWTSSRRTDSLSSLRPIKVDSQ ... :..:.:::::..::.: .::.:..::::::::..:.:: :.: : :.::::.:.: CCDS13 FDRVRSIIVSAGPWVAFEQSNFRGEMFILEKGEYPRWNTWSSSYRSDRLMSFRPIKMDAQ 90 100 110 120 130 140 110 120 130 140 150 160 pF1KE0 EHKIILYENPNFTGKKMEIIDDDVPSFHAHGYQEKVSSVRVQSGTWVGYQYPGYRGLQYL :::: :.:. :: :. .:: ::.::. ..:....:.::.:.:::::::::::::: ::: CCDS13 EHKISLFEGANFKGNTIEIQGDDAPSLWVYGFSDRVGSVKVSSGTWVGYQYPGYRGYQYL 150 160 170 180 190 200 170 180 190 200 pF1KE0 LEKGDYKDSSDFGAPHPQVQSVRRIRDMQWHQRGAFHPSN :: ::.. ...:: .::.::.::.:: ::: .:.: CCDS13 LEPGDFRHWNEWGAFQPQMQSLRRLRDKQWHLEGSFPVLATEPPK 210 220 230 240 250 >>CCDS11249.1 CRYBA1 gene_id:1411|Hs108|chr17 (215 aa) initn: 511 init1: 282 opt: 579 Z-score: 747.3 bits: 145.3 E(32554): 2.7e-35 Smith-Waterman score: 585; 46.1% identity (76.4% similar) in 191 aa overlap (12-191:25-214) 10 20 30 40 pF1KE0 MASDHQTQAGKPQSLNP-KIIIFEQENFQGHSHELNGPCPNLKETGV : ::.: :: :..::::::. :... :::..: . CCDS11 METQAEQQELETLPTTKMAQTNPTPGSLGPWKITIYDQENFQGKRMEFTSSCPNVSERSF 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE0 EKAGSVLVQAGPWVGYEQANCKGEQFVFEKGEYPRWDSWTSSR--RTDSLSSLRPI-KVD ... :. :..: :.:::... :.::..:.:::::::.:..: . . : :.::: ... CCDS11 DNVRSLKVESGAWIGYEHTSFCGQQFILERGEYPRWDAWSGSNAYHIERLMSFRPICSAN 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE0 SQEHKIILYENPNFTGKKMEIIDDDVPSFHAHG-YQEKVSSVRVQSGTWVGYQYPGYRGL .: :. ..:. :: :.. :: .:: ::..: : ....:.:...:::.:: :::::::: CCDS11 HKESKMTIFEKENFIGRQWEI-SDDYPSLQAMGWFNNEVGSMKIQSGAWVCYQYPGYRGY 130 140 150 160 170 170 180 190 200 pF1KE0 QYLLE----KGDYKDSSDFG--APHPQVQSVRRIRDMQWHQRGAFHPSN ::.:: :::: ..: : :.::.:::. CCDS11 QYILECDHHGGDYKHWREWGSHAQTSQIQSIRRIQQ 180 190 200 210 >>CCDS13841.1 CRYBA4 gene_id:1413|Hs108|chr22 (196 aa) initn: 477 init1: 237 opt: 512 Z-score: 662.0 bits: 129.4 E(32554): 1.5e-30 Smith-Waterman score: 531; 41.6% identity (75.8% similar) in 190 aa overlap (13-191:7-195) 10 20 30 40 50 pF1KE0 MASDHQTQAGKPQSLNP-KIIIFEQENFQGHSHELNGPCPNLKETGVEKAGSVLVQAGPW .: .: :........:::. ::... ::.. : : : . :. : .: : CCDS13 MTLQCTKSAGPWKMVVWDEDGFQGRRHEFTAECPSVLELGFETVRSLKVLSGAW 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 VGYEQANCKGEQFVFEKGEYPRWDSW--TSSRRTDSLSSLRPIK-VDSQEHKIILYENPN ::.:.:. .:.:...:.:::: ::.: ... .. :.:.:: .. .. .. ..:. : CCDS13 VGFEHAGFQGQQYILERGEYPSWDAWGGNTAYPAERLTSFRPAACANHRDSRLTIFEQEN 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 FTGKKMEIIDDDVPSFHAHGYQ-EKVSSVRVQSGTWVGYQYPGYRGLQYLLE----KGDY : ::: :. .:: ::..: :.. ..:.: .:.::.:: :.:::::.::.:: .::: CCDS13 FLGKKGEL-SDDYPSLQAMGWEGNEVGSFHVHSGAWVCSQFPGYRGFQYVLECDHHSGDY 120 130 140 150 160 170 180 190 200 pF1KE0 KDSSDFG--APHPQVQSVRRIRDMQWHQRGAFHPSN : ..: :: ::::.:::. CCDS13 KHFREWGSHAPTFQVQSIRRIQQ 180 190 >>CCDS2429.1 CRYBA2 gene_id:1412|Hs108|chr2 (197 aa) initn: 383 init1: 193 opt: 478 Z-score: 618.4 bits: 121.3 E(32554): 4e-28 Smith-Waterman score: 478; 37.8% identity (71.4% similar) in 196 aa overlap (7-191:2-196) 10 20 30 40 50 pF1KE0 MASDHQTQAGKPQSLNPKIIIFEQENFQGHSHELNGPCPNLKETG-VEKAGSVLVQAGPW ..: : .. ....:.:::. .: . : :. : : . .. :: :. : : CCDS24 MSSAPAPGPAPASLTLWDEEDFQGRRCRLLSDCANVCERGGLPRVRSVKVENGVW 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 VGYEQANCKGEQFVFEKGEYPRWDSWT--SSRRTDSLSSLRPIK-VDSQEHKIILYENPN :..: . .:.::..:::.::::..:. ::. ...: :.::. .. .. .. :.:. : CCDS24 VAFEYPDFQGQQFILEKGDYPRWSAWSGSSSHNSNQLLSFRPVLCANHNDSRVTLFEGDN 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 FTGKKMEIIDDDVPSFHAHGYQEK-VSSVRVQSGTWVGYQYPGYRGLQYLLEK----GDY : : :....:: ::. . :. : :.:..:.::.::.:::::::: ::.::. :.. CCDS24 FQGCKFDLVDD-YPSLPSMGWASKDVGSLKVSSGAWVAYQYPGYRGYQYVLERDRHSGEF 120 130 140 150 160 170 180 190 200 pF1KE0 KDSSDFG--APHPQVQSVRRIRDMQWHQRGAFHPSN ...: : :.::.::.. CCDS24 CTYGELGTQAHTGQLQSIRRVQH 180 190 >>CCDS3275.1 CRYGS gene_id:1427|Hs108|chr3 (178 aa) initn: 318 init1: 199 opt: 406 Z-score: 526.9 bits: 104.2 E(32554): 5e-23 Smith-Waterman score: 406; 35.6% identity (69.0% similar) in 174 aa overlap (18-190:7-176) 10 20 30 40 50 60 pF1KE0 MASDHQTQAGKPQSLNPKIIIFEQENFQGHSHELNGPCPNLKETGVEKAGSVLVQAGPWV :: ..:..::::. .. . : ... : . . .:. :..: :. CCDS32 MSKTGTKITFYEDKNFQGRRYDCDCDCADFH-TYLSRCNSIKVEGGTWA 10 20 30 40 70 80 90 100 110 pF1KE0 GYEQANCKGEQFVFEKGEYPRWDSWTSSRRTDSLSSLRPIKVDSQ-EHKIILYENPNFTG ::. : : .... .::::... : . .: ::: : ... : ..:: ..:. .:.: CCDS32 VYERPNFAGYMYILPQGEYPEYQRWMG--LNDRLSSCRAVHLPSGGQYKIQIFEKGDFSG 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE0 KKMEIIDDDVPSFHAHGYQEKVSSVRVQSGTWVGYQYPGYRGLQYLLEKGDYKDSSDFGA . .: .: ::. . ..... : .: :.:. :. :.::: ::::.: .:. :.:: CCDS32 QMYETTED-CPSIMEQFHMREIHSCKVLEGVWIFYELPNYRGRQYLLDKKEYRKPIDWGA 110 120 130 140 150 160 180 190 200 pF1KE0 PHPQVQSVRRIRDMQWHQRGAFHPSN : ::: ::: CCDS32 ASPAVQSFRRIVE 170 >>CCDS2380.1 CRYGB gene_id:1419|Hs108|chr2 (175 aa) initn: 414 init1: 193 opt: 398 Z-score: 516.8 bits: 102.3 E(32554): 1.8e-22 Smith-Waterman score: 398; 34.7% identity (67.0% similar) in 176 aa overlap (18-193:3-174) 10 20 30 40 50 60 pF1KE0 MASDHQTQAGKPQSLNPKIIIFEQENFQGHSHELNGPCPNLKETGVEKAGSVLVQAGPWV :: ..:.. :::.:.: . ::::. . .:. :..: :. CCDS23 MGKITFYEDRAFQGRSYECTTDCPNLQPY-FSRCNSIRVESGCWM 10 20 30 40 70 80 90 100 110 120 pF1KE0 GYEQANCKGEQFVFEKGEYPRWDSWTSSRRTDSLSSLRPIKVDSQEHKIILYENPNFTGK ::. : .:.:. ...:::: ...: . .::. : : : ... .:. .. :. CCDS23 IYERPNYQGHQYFLRRGEYPDYQQWMGL--SDSIRSCCLIPPHSGAYRMKIYDRDELRGQ 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE0 KMEIIDDDVPSFHAHGYQEKVSSVRVQSGTWVGYQYPGYRGLQYLLEKGDYKDSSDFGAP :. :: . : . . . .. :. : :.:. :..:.::: ::::. :.:. :.::: CCDS23 MSELTDDCI-SVQDRFHLTEIHSLNVLEGSWILYEMPNYRGRQYLLRPGEYRRFLDWGAP 110 120 130 140 150 160 190 200 pF1KE0 HPQVQSVRRIRDMQWHQRGAFHPSN . .: :.::. :. CCDS23 NAKVGSLRRVMDLY 170 >>CCDS2379.1 CRYGC gene_id:1420|Hs108|chr2 (174 aa) initn: 385 init1: 164 opt: 388 Z-score: 504.0 bits: 100.0 E(32554): 9.4e-22 Smith-Waterman score: 388; 36.0% identity (66.9% similar) in 178 aa overlap (18-193:3-173) 10 20 30 40 50 60 pF1KE0 MASDHQTQAGKPQSLNPKIIIFEQENFQGHSHELNGPCPNLKETGVEKAGSVLVQAGPWV :: ..:.. :::.:.: . ::::. . .:. :..: :. CCDS23 MGKITFYEDRAFQGRSYETTTDCPNLQPY-FSRCNSIRVESGCWM 10 20 30 40 70 80 90 100 110 pF1KE0 GYEQANCKGEQFVFEKGEYPRWDSWTSSRRTDSLSS--LRPIKVDSQEHKIILYENPNFT ::. : .:.:.....:::: ...: . .::. : : : :. :.. ::: . CCDS23 LYERPNYQGQQYLLRRGEYPDYQQWMGL--SDSIRSCCLIPQTVS---HRLRLYEREDHK 50 60 70 80 90 120 130 140 150 160 170 pF1KE0 GKKMEIIDDDVPSFHAHGYQEKVSSVRVQSGTWVGYQYPGYRGLQYLLEKGDYKDSSDFG : ::. ..: ::.. . . .. :..: : :: :. :.::: ::::. .:. .:.: CCDS23 GLMMEL-SEDCPSIQDRFHLSEIRSLHVLEGCWVLYELPNYRGRQYLLRPQEYRRCQDWG 100 110 120 130 140 150 180 190 200 pF1KE0 APHPQVQSVRRIRDMQWHQRGAFHPSN : .. :.::. :. CCDS23 AMDAKAGSLRRVVDLY 160 170 >>CCDS33367.1 CRYGA gene_id:1418|Hs108|chr2 (174 aa) initn: 385 init1: 173 opt: 380 Z-score: 493.7 bits: 98.1 E(32554): 3.5e-21 Smith-Waterman score: 380; 36.0% identity (65.2% similar) in 178 aa overlap (18-193:3-173) 10 20 30 40 50 60 pF1KE0 MASDHQTQAGKPQSLNPKIIIFEQENFQGHSHELNGPCPNLKETGVEKAGSVLVQAGPWV :: ..:...:::. .. . ::::. . . .:. :..: :. CCDS33 MGKITFYEDRDFQGRCYNCISDCPNLR-VYFSRCNSIRVDSGCWM 10 20 30 40 70 80 90 100 110 120 pF1KE0 GYEQANCKGEQFVFEKGEYPRWDSWTSSRRTDSLSSLRPIKVDSQEHKIILYENPNFTGK ::. : .:.:. ...:.:: .. : . .::..: : : :. ::. ::: .. : CCDS33 LYERPNYQGHQYFLRRGKYPDYQHWMGL--SDSVQSCRIIPHTSS-HKLRLYERDDYRGL 50 60 70 80 90 100 130 140 150 160 170 pF1KE0 KMEIIDDD--VPSFHAHGYQEKVSSVRVQSGTWVGYQYPGYRGLQYLLEKGDYKDSSDFG :. :: :: . .. :..: : :: :..:.::: ::::. :::. :.: CCDS33 MSELTDDCACVPELF---RLPEIYSLHVLEGCWVLYEMPNYRGRQYLLRPGDYRRYHDWG 110 120 130 140 150 180 190 200 pF1KE0 APHPQVQSVRRIRDMQWHQRGAFHPSN . .: :.::. :. CCDS33 GADAKVGSLRRVTDLY 160 170 205 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 03:56:41 2016 done: Thu Nov 3 03:56:41 2016 Total Scan time: 2.140 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]