FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0531, 411 aa 1>>>pF1KE0531 411 - 411 aa - 411 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9405+/-0.000385; mu= 18.8867+/- 0.024 mean_var=61.6467+/-12.345, 0's: 0 Z-trim(112.1): 18 B-trim: 211 in 1/51 Lambda= 0.163350 statistics sampled from 20869 (20875) to 20869 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.616), E-opt: 0.2 (0.245), width: 16 Scan time: 7.960 The best scores are: opt bits E(85289) XP_005261672 (OMIM: 104170,609241,609242) PREDICTE ( 411) 2872 685.6 5.9e-197 XP_005261673 (OMIM: 104170,609241,609242) PREDICTE ( 411) 2872 685.6 5.9e-197 NP_000253 (OMIM: 104170,609241,609242) alpha-N-ace ( 411) 2872 685.6 5.9e-197 NP_000160 (OMIM: 300644,301500) alpha-galactosidas ( 429) 1282 310.9 3.9e-84 >>XP_005261672 (OMIM: 104170,609241,609242) PREDICTED: a (411 aa) initn: 2872 init1: 2872 opt: 2872 Z-score: 3656.9 bits: 685.6 E(85289): 5.9e-197 Smith-Waterman score: 2872; 100.0% identity (100.0% similar) in 411 aa overlap (1-411:1-411) 10 20 30 40 50 60 pF1KE0 MLLKTVLLLGHVAQVLMLDNGLLQTPPMGWLAWERFRCNINCDEDPKNCISEQLFMEMAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MLLKTVLLLGHVAQVLMLDNGLLQTPPMGWLAWERFRCNINCDEDPKNCISEQLFMEMAD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 RMAQDGWRDMGYTYLNIDDCWIGGRDASGRLMPDPKRFPHGIPFLADYVHSLGLKLGIYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RMAQDGWRDMGYTYLNIDDCWIGGRDASGRLMPDPKRFPHGIPFLADYVHSLGLKLGIYA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 DMGNFTCMGYPGTTLDKVVQDAQTFAEWKVDMLKLDGCFSTPEERAQGYPKMAAALNATG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DMGNFTCMGYPGTTLDKVVQDAQTFAEWKVDMLKLDGCFSTPEERAQGYPKMAAALNATG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 RPIAFSCSWPAYEGGLPPRVNYSLLADICNLWRNYDDIQDSWWSVLSILNWFVEHQDILQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RPIAFSCSWPAYEGGLPPRVNYSLLADICNLWRNYDDIQDSWWSVLSILNWFVEHQDILQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 PVAGPGHWNDPDMLLIGNFGLSLEQSRAQMALWTVLAAPLLMSTDLRTISAQNMDILQNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PVAGPGHWNDPDMLLIGNFGLSLEQSRAQMALWTVLAAPLLMSTDLRTISAQNMDILQNP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 LMIKINQDPLGIQGRRIHKEKSLIEVYMRPLSNKASALVFFSCRTDMPYRYHSSLGQLNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LMIKINQDPLGIQGRRIHKEKSLIEVYMRPLSNKASALVFFSCRTDMPYRYHSSLGQLNF 310 320 330 340 350 360 370 380 390 400 410 pF1KE0 TGSVIYEAQDVYSGDIISGLRDETNFTVIINPSGVVMWYLYPIKNLEMSQQ ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TGSVIYEAQDVYSGDIISGLRDETNFTVIINPSGVVMWYLYPIKNLEMSQQ 370 380 390 400 410 >>XP_005261673 (OMIM: 104170,609241,609242) PREDICTED: a (411 aa) initn: 2872 init1: 2872 opt: 2872 Z-score: 3656.9 bits: 685.6 E(85289): 5.9e-197 Smith-Waterman score: 2872; 100.0% identity (100.0% similar) in 411 aa overlap (1-411:1-411) 10 20 30 40 50 60 pF1KE0 MLLKTVLLLGHVAQVLMLDNGLLQTPPMGWLAWERFRCNINCDEDPKNCISEQLFMEMAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MLLKTVLLLGHVAQVLMLDNGLLQTPPMGWLAWERFRCNINCDEDPKNCISEQLFMEMAD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 RMAQDGWRDMGYTYLNIDDCWIGGRDASGRLMPDPKRFPHGIPFLADYVHSLGLKLGIYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RMAQDGWRDMGYTYLNIDDCWIGGRDASGRLMPDPKRFPHGIPFLADYVHSLGLKLGIYA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 DMGNFTCMGYPGTTLDKVVQDAQTFAEWKVDMLKLDGCFSTPEERAQGYPKMAAALNATG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DMGNFTCMGYPGTTLDKVVQDAQTFAEWKVDMLKLDGCFSTPEERAQGYPKMAAALNATG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 RPIAFSCSWPAYEGGLPPRVNYSLLADICNLWRNYDDIQDSWWSVLSILNWFVEHQDILQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RPIAFSCSWPAYEGGLPPRVNYSLLADICNLWRNYDDIQDSWWSVLSILNWFVEHQDILQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 PVAGPGHWNDPDMLLIGNFGLSLEQSRAQMALWTVLAAPLLMSTDLRTISAQNMDILQNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PVAGPGHWNDPDMLLIGNFGLSLEQSRAQMALWTVLAAPLLMSTDLRTISAQNMDILQNP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 LMIKINQDPLGIQGRRIHKEKSLIEVYMRPLSNKASALVFFSCRTDMPYRYHSSLGQLNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LMIKINQDPLGIQGRRIHKEKSLIEVYMRPLSNKASALVFFSCRTDMPYRYHSSLGQLNF 310 320 330 340 350 360 370 380 390 400 410 pF1KE0 TGSVIYEAQDVYSGDIISGLRDETNFTVIINPSGVVMWYLYPIKNLEMSQQ ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TGSVIYEAQDVYSGDIISGLRDETNFTVIINPSGVVMWYLYPIKNLEMSQQ 370 380 390 400 410 >>NP_000253 (OMIM: 104170,609241,609242) alpha-N-acetylg (411 aa) initn: 2872 init1: 2872 opt: 2872 Z-score: 3656.9 bits: 685.6 E(85289): 5.9e-197 Smith-Waterman score: 2872; 100.0% identity (100.0% similar) in 411 aa overlap (1-411:1-411) 10 20 30 40 50 60 pF1KE0 MLLKTVLLLGHVAQVLMLDNGLLQTPPMGWLAWERFRCNINCDEDPKNCISEQLFMEMAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MLLKTVLLLGHVAQVLMLDNGLLQTPPMGWLAWERFRCNINCDEDPKNCISEQLFMEMAD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 RMAQDGWRDMGYTYLNIDDCWIGGRDASGRLMPDPKRFPHGIPFLADYVHSLGLKLGIYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 RMAQDGWRDMGYTYLNIDDCWIGGRDASGRLMPDPKRFPHGIPFLADYVHSLGLKLGIYA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 DMGNFTCMGYPGTTLDKVVQDAQTFAEWKVDMLKLDGCFSTPEERAQGYPKMAAALNATG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 DMGNFTCMGYPGTTLDKVVQDAQTFAEWKVDMLKLDGCFSTPEERAQGYPKMAAALNATG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 RPIAFSCSWPAYEGGLPPRVNYSLLADICNLWRNYDDIQDSWWSVLSILNWFVEHQDILQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 RPIAFSCSWPAYEGGLPPRVNYSLLADICNLWRNYDDIQDSWWSVLSILNWFVEHQDILQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 PVAGPGHWNDPDMLLIGNFGLSLEQSRAQMALWTVLAAPLLMSTDLRTISAQNMDILQNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 PVAGPGHWNDPDMLLIGNFGLSLEQSRAQMALWTVLAAPLLMSTDLRTISAQNMDILQNP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 LMIKINQDPLGIQGRRIHKEKSLIEVYMRPLSNKASALVFFSCRTDMPYRYHSSLGQLNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 LMIKINQDPLGIQGRRIHKEKSLIEVYMRPLSNKASALVFFSCRTDMPYRYHSSLGQLNF 310 320 330 340 350 360 370 380 390 400 410 pF1KE0 TGSVIYEAQDVYSGDIISGLRDETNFTVIINPSGVVMWYLYPIKNLEMSQQ ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 TGSVIYEAQDVYSGDIISGLRDETNFTVIINPSGVVMWYLYPIKNLEMSQQ 370 380 390 400 410 >>NP_000160 (OMIM: 300644,301500) alpha-galactosidase A (429 aa) initn: 1102 init1: 774 opt: 1282 Z-score: 1631.6 bits: 310.9 E(85289): 3.9e-84 Smith-Waterman score: 1282; 49.9% identity (72.9% similar) in 399 aa overlap (18-409:32-424) 10 20 30 40 pF1KE0 MLLKTVLLLGHVAQVLMLDNGLLQTPPMGWLAWERFRCNINCDEDPK ::::: .:: :::: :::: ::..:.:.: NP_000 QLRNPELHLGCALALRFLALVSWDIPGARALDNGLARTPTMGWLHWERFMCNLDCQEEPD 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE0 NCISEQLFMEMADRMAQDGWRDMGYTYLNIDDCWIGG-RDASGRLMPDPKRFPHGIPFLA .::::.::::::. :...::.: :: :: :::::.. ::. :::. ::.:::::: :: NP_000 SCISEKLFMEMAELMVSEGWKDAGYEYLCIDDCWMAPQRDSEGRLQADPQRFPHGIRQLA 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE0 DYVHSLGLKLGIYADMGNFTCMGYPGTTLDKVVQDAQTFAEWKVDMLKLDGCF-STPEER .:::: :::::::::.:: :: :.::. . ::::::.: ::.::.:::. .. :. NP_000 NYVHSKGLKLGIYADVGNKTCAGFPGS-FGYYDIDAQTFADWGVDLLKFDGCYCDSLENL 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE0 AQGYPKMAAALNATGRPIAFSCSWPAYEGGLPPRVNYSLLADICNLWRNYDDIQDSWWSV :.:: .:. ::: ::: :..:: :: : . . ::. . . :: :::. ::.::: :. NP_000 ADGYKHMSLALNRTGRSIVYSCEWPLYMWPFQ-KPNYTEIRQYCNHWRNFADIDDSWKSI 190 200 210 220 230 230 240 250 260 270 280 pF1KE0 LSILNWFVEHQDILQPVAGPGHWNDPDMLLIGNFGLSLEQSRAQMALWTVLAAPLLMSTD :::.: .:. . ::::: :::::::.::::::: .:. .:::::...::::.::.: NP_000 KSILDWTSFNQERIVDVAGPGGWNDPDMLVIGNFGLSWNQQVTQMALWAIMAAPLFMSND 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE0 LRTISAQNMDILQNPLMIKINQDPLGIQGRRIHKEKSLIEVYMRPLSNKASALVFFSCRT :: :: : .::. .: ::::::: :: .... .. ::. ::::. : :..... : NP_000 LRHISPQAKALLQDKDVIAINQDPLGKQGYQLRQGDNF-EVWERPLSGLAWAVAMIN-RQ 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE0 DM--PYRYH---SSLGQLNFTGSVIYEAQDVYSGDIISGLRDETNFTVIINPSGVVMWYL .. : : .:::. . . . .: . .. . . . :::.:.:. : NP_000 EIGGPRSYTIAVASLGKGVACNPACFITQLLPVKRKLGFYEWTSRLRSHINPTGTVLLQL 360 370 380 390 400 410 410 pF1KE0 YPIKNLEMSQQ ....:: NP_000 E--NTMQMSLKDLL 420 411 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 01:26:01 2016 done: Thu Nov 3 01:26:02 2016 Total Scan time: 7.960 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]