FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0534, 441 aa 1>>>pF1KE0534 441 - 441 aa - 441 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.4272+/-0.000331; mu= 17.2815+/- 0.021 mean_var=70.4770+/-14.172, 0's: 0 Z-trim(116.5): 61 B-trim: 0 in 0/51 Lambda= 0.152774 statistics sampled from 27677 (27738) to 27677 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.698), E-opt: 0.2 (0.325), width: 16 Scan time: 9.280 The best scores are: opt bits E(85289) NP_005437 (OMIM: 608077) P2X purinoceptor 6 isofor ( 441) 3098 691.8 9.6e-199 NP_001153026 (OMIM: 608077) P2X purinoceptor 6 iso ( 415) 2720 608.4 1.1e-173 XP_011528800 (OMIM: 608077) PREDICTED: P2X purinoc ( 539) 2339 524.5 2.6e-148 XP_016884557 (OMIM: 608077) PREDICTED: P2X purinoc ( 393) 2336 523.8 3.2e-148 XP_016884558 (OMIM: 608077) PREDICTED: P2X purinoc ( 391) 2232 500.8 2.5e-141 XP_016884556 (OMIM: 608077) PREDICTED: P2X purinoc ( 417) 2232 500.9 2.6e-141 XP_016884564 (OMIM: 608077) PREDICTED: P2X purinoc ( 290) 2019 453.8 2.6e-127 XP_016884562 (OMIM: 608077) PREDICTED: P2X purinoc ( 290) 2019 453.8 2.6e-127 XP_016884563 (OMIM: 608077) PREDICTED: P2X purinoc ( 290) 2019 453.8 2.6e-127 XP_016884565 (OMIM: 608077) PREDICTED: P2X purinoc ( 290) 2019 453.8 2.6e-127 XP_016884561 (OMIM: 608077) PREDICTED: P2X purinoc ( 290) 2019 453.8 2.6e-127 XP_011528802 (OMIM: 608077) PREDICTED: P2X purinoc ( 513) 1961 441.2 3e-123 XP_011528804 (OMIM: 608077) PREDICTED: P2X purinoc ( 324) 1836 413.5 4e-115 XP_016884555 (OMIM: 608077) PREDICTED: P2X purinoc ( 425) 1836 413.6 5e-115 XP_005261876 (OMIM: 608077) PREDICTED: P2X purinoc ( 473) 1836 413.6 5.5e-115 XP_011528801 (OMIM: 608077) PREDICTED: P2X purinoc ( 515) 1473 333.6 7.2e-91 XP_016884559 (OMIM: 608077) PREDICTED: P2X purinoc ( 388) 1260 286.6 7.7e-77 XP_011528803 (OMIM: 608077) PREDICTED: P2X purinoc ( 388) 1260 286.6 7.7e-77 NP_002552 (OMIM: 602836) P2X purinoceptor 5 isofor ( 422) 1106 252.7 1.4e-66 NP_002549 (OMIM: 600845,609821) P2X purinoceptor 1 ( 399) 1101 251.6 2.8e-66 NP_001191448 (OMIM: 602836) P2X purinoceptor 5 iso ( 421) 1084 247.8 3.9e-65 XP_016874524 (OMIM: 600844,608224) PREDICTED: P2X ( 462) 1028 235.5 2.2e-61 NP_733782 (OMIM: 600844,608224) P2X purinoceptor 2 ( 471) 1027 235.3 2.6e-61 NP_777362 (OMIM: 600844,608224) P2X purinoceptor 2 ( 404) 1005 230.4 6.6e-60 XP_011522201 (OMIM: 600845,609821) PREDICTED: P2X ( 411) 993 227.8 4.2e-59 XP_005266213 (OMIM: 600844,608224) PREDICTED: P2X ( 430) 965 221.6 3.1e-57 XP_005266212 (OMIM: 600844,608224) PREDICTED: P2X ( 488) 965 221.6 3.5e-57 NP_733783 (OMIM: 600844,608224) P2X purinoceptor 2 ( 497) 965 221.7 3.5e-57 NP_001248327 (OMIM: 600846) P2X purinoceptor 4 iso ( 341) 910 209.4 1.2e-53 NP_002551 (OMIM: 600846) P2X purinoceptor 4 isofor ( 388) 910 209.5 1.3e-53 NP_001269094 (OMIM: 600844,608224) P2X purinocepto ( 349) 887 204.4 3.9e-52 XP_011522199 (OMIM: 600845,609821) PREDICTED: P2X ( 419) 844 194.9 3.3e-49 NP_001243725 (OMIM: 600846) P2X purinoceptor 4 iso ( 404) 819 189.4 1.4e-47 XP_005266211 (OMIM: 600844,608224) PREDICTED: P2X ( 512) 812 187.9 5.1e-47 NP_002553 (OMIM: 602566) P2X purinoceptor 7 [Homo ( 595) 785 182.0 3.6e-45 XP_016884560 (OMIM: 608077) PREDICTED: P2X purinoc ( 322) 757 175.7 1.6e-43 XP_011522198 (OMIM: 600845,609821) PREDICTED: P2X ( 431) 736 171.1 4.9e-42 NP_057402 (OMIM: 600844,608224) P2X purinoceptor 2 ( 447) 727 169.2 2e-41 NP_777361 (OMIM: 600844,608224) P2X purinoceptor 2 ( 379) 717 166.9 8e-41 NP_036358 (OMIM: 600844,608224) P2X purinoceptor 2 ( 399) 691 161.2 4.5e-39 XP_011533088 (OMIM: 600844,608224) PREDICTED: P2X ( 473) 665 155.5 2.7e-37 XP_011536721 (OMIM: 602566) PREDICTED: P2X purinoc ( 491) 660 154.4 6e-37 NP_002550 (OMIM: 600843) P2X purinoceptor 3 [Homo ( 397) 623 146.2 1.4e-34 XP_011543371 (OMIM: 600843) PREDICTED: P2X purinoc ( 397) 623 146.2 1.4e-34 XP_011543372 (OMIM: 600843) PREDICTED: P2X purinoc ( 397) 623 146.2 1.4e-34 XP_011543373 (OMIM: 600843) PREDICTED: P2X purinoc ( 395) 619 145.3 2.6e-34 XP_011522200 (OMIM: 600845,609821) PREDICTED: P2X ( 414) 610 143.4 1.1e-33 XP_011543374 (OMIM: 600843) PREDICTED: P2X purinoc ( 323) 598 140.7 5.5e-33 XP_016874853 (OMIM: 602566) PREDICTED: P2X purinoc ( 475) 573 135.2 3.5e-31 XP_016874854 (OMIM: 602566) PREDICTED: P2X purinoc ( 475) 573 135.2 3.5e-31 >>NP_005437 (OMIM: 608077) P2X purinoceptor 6 isoform 1 (441 aa) initn: 3098 init1: 3098 opt: 3098 Z-score: 3689.1 bits: 691.8 E(85289): 9.6e-199 Smith-Waterman score: 3098; 100.0% identity (100.0% similar) in 441 aa overlap (1-441:1-441) 10 20 30 40 50 60 pF1KE0 MCPQLAGAGSMGSPGATTGWGLLDYKTEKYVMTRNWRVGALQRLLQFGIVVYVVGWALLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MCPQLAGAGSMGSPGATTGWGLLDYKTEKYVMTRNWRVGALQRLLQFGIVVYVVGWALLA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 KKGYQERDLEPQFSIITKLKGVSVTQIKELGNRLWDVADFVKPPQGENVFFLVTNFLVTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 KKGYQERDLEPQFSIITKLKGVSVTQIKELGNRLWDVADFVKPPQGENVFFLVTNFLVTP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 AQVQGRCPEHPSVPLANCWVDEDCPEGEGGTHSHGVKTGQCVVFNGTHRTCEIWSWCPVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 AQVQGRCPEHPSVPLANCWVDEDCPEGEGGTHSHGVKTGQCVVFNGTHRTCEIWSWCPVE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 SGVVPSRPLLAQAQNFTLFIKNTVTFSKFNFSKSNALETWDPTYFKHCRYEPQFSPYCPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 SGVVPSRPLLAQAQNFTLFIKNTVTFSKFNFSKSNALETWDPTYFKHCRYEPQFSPYCPV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 FRIGDLVAKAGGTFEDLALLGGSVGIRVHWDCDLDTGDSGCWPHYSFQLQEKSYNFRTAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 FRIGDLVAKAGGTFEDLALLGGSVGIRVHWDCDLDTGDSGCWPHYSFQLQEKSYNFRTAT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 HWWEQPGVEARTLLKLYGIRFDILVTGQAGKFGLIPTAVTLGTGAAWLGVVTFFCDLLLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 HWWEQPGVEARTLLKLYGIRFDILVTGQAGKFGLIPTAVTLGTGAAWLGVVTFFCDLLLL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 YVDREAHFYWRTKYEEAKAPKATANSVWRELALASQARLAECLRRSSAPAPTATAAGSQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 YVDREAHFYWRTKYEEAKAPKATANSVWRELALASQARLAECLRRSSAPAPTATAAGSQT 370 380 390 400 410 420 430 440 pF1KE0 QTPGWPCPSSDTHLPTHSGSL ::::::::::::::::::::: NP_005 QTPGWPCPSSDTHLPTHSGSL 430 440 >>NP_001153026 (OMIM: 608077) P2X purinoceptor 6 isoform (415 aa) initn: 2720 init1: 2720 opt: 2720 Z-score: 3239.2 bits: 608.4 E(85289): 1.1e-173 Smith-Waterman score: 2864; 94.1% identity (94.1% similar) in 441 aa overlap (1-441:1-415) 10 20 30 40 50 60 pF1KE0 MCPQLAGAGSMGSPGATTGWGLLDYKTEKYVMTRNWRVGALQRLLQFGIVVYVVGWALLA ::::::::::::::::::::::::::::: ::::: NP_001 MCPQLAGAGSMGSPGATTGWGLLDYKTEK--------------------------WALLA 10 20 30 70 80 90 100 110 120 pF1KE0 KKGYQERDLEPQFSIITKLKGVSVTQIKELGNRLWDVADFVKPPQGENVFFLVTNFLVTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KKGYQERDLEPQFSIITKLKGVSVTQIKELGNRLWDVADFVKPPQGENVFFLVTNFLVTP 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE0 AQVQGRCPEHPSVPLANCWVDEDCPEGEGGTHSHGVKTGQCVVFNGTHRTCEIWSWCPVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AQVQGRCPEHPSVPLANCWVDEDCPEGEGGTHSHGVKTGQCVVFNGTHRTCEIWSWCPVE 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE0 SGVVPSRPLLAQAQNFTLFIKNTVTFSKFNFSKSNALETWDPTYFKHCRYEPQFSPYCPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SGVVPSRPLLAQAQNFTLFIKNTVTFSKFNFSKSNALETWDPTYFKHCRYEPQFSPYCPV 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE0 FRIGDLVAKAGGTFEDLALLGGSVGIRVHWDCDLDTGDSGCWPHYSFQLQEKSYNFRTAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FRIGDLVAKAGGTFEDLALLGGSVGIRVHWDCDLDTGDSGCWPHYSFQLQEKSYNFRTAT 220 230 240 250 260 270 310 320 330 340 350 360 pF1KE0 HWWEQPGVEARTLLKLYGIRFDILVTGQAGKFGLIPTAVTLGTGAAWLGVVTFFCDLLLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HWWEQPGVEARTLLKLYGIRFDILVTGQAGKFGLIPTAVTLGTGAAWLGVVTFFCDLLLL 280 290 300 310 320 330 370 380 390 400 410 420 pF1KE0 YVDREAHFYWRTKYEEAKAPKATANSVWRELALASQARLAECLRRSSAPAPTATAAGSQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YVDREAHFYWRTKYEEAKAPKATANSVWRELALASQARLAECLRRSSAPAPTATAAGSQT 340 350 360 370 380 390 430 440 pF1KE0 QTPGWPCPSSDTHLPTHSGSL ::::::::::::::::::::: NP_001 QTPGWPCPSSDTHLPTHSGSL 400 410 >>XP_011528800 (OMIM: 608077) PREDICTED: P2X purinocepto (539 aa) initn: 2339 init1: 2339 opt: 2339 Z-score: 2783.7 bits: 524.5 E(85289): 2.6e-148 Smith-Waterman score: 2339; 99.7% identity (100.0% similar) in 330 aa overlap (1-330:1-330) 10 20 30 40 50 60 pF1KE0 MCPQLAGAGSMGSPGATTGWGLLDYKTEKYVMTRNWRVGALQRLLQFGIVVYVVGWALLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MCPQLAGAGSMGSPGATTGWGLLDYKTEKYVMTRNWRVGALQRLLQFGIVVYVVGWALLA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 KKGYQERDLEPQFSIITKLKGVSVTQIKELGNRLWDVADFVKPPQGENVFFLVTNFLVTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KKGYQERDLEPQFSIITKLKGVSVTQIKELGNRLWDVADFVKPPQGENVFFLVTNFLVTP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 AQVQGRCPEHPSVPLANCWVDEDCPEGEGGTHSHGVKTGQCVVFNGTHRTCEIWSWCPVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AQVQGRCPEHPSVPLANCWVDEDCPEGEGGTHSHGVKTGQCVVFNGTHRTCEIWSWCPVE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 SGVVPSRPLLAQAQNFTLFIKNTVTFSKFNFSKSNALETWDPTYFKHCRYEPQFSPYCPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SGVVPSRPLLAQAQNFTLFIKNTVTFSKFNFSKSNALETWDPTYFKHCRYEPQFSPYCPV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 FRIGDLVAKAGGTFEDLALLGGSVGIRVHWDCDLDTGDSGCWPHYSFQLQEKSYNFRTAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FRIGDLVAKAGGTFEDLALLGGSVGIRVHWDCDLDTGDSGCWPHYSFQLQEKSYNFRTAT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 HWWEQPGVEARTLLKLYGIRFDILVTGQAGKFGLIPTAVTLGTGAAWLGVVTFFCDLLLL ::::::::::::::::::::::::::::.: XP_011 HWWEQPGVEARTLLKLYGIRFDILVTGQVGTGREVRAHPHGRHTGHRGSLAGRGECEHCG 310 320 330 340 350 360 >>XP_016884557 (OMIM: 608077) PREDICTED: P2X purinocepto (393 aa) initn: 2359 init1: 2336 opt: 2336 Z-score: 2782.1 bits: 523.8 E(85289): 3.2e-148 Smith-Waterman score: 2663; 89.1% identity (89.1% similar) in 441 aa overlap (1-441:1-393) 10 20 30 40 50 60 pF1KE0 MCPQLAGAGSMGSPGATTGWGLLDYKTEKYVMTRNWRVGALQRLLQFGIVVYVVGWALLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MCPQLAGAGSMGSPGATTGWGLLDYKTEKYVMTRNWRVGALQRLLQFGIVVYVVGWALLA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 KKGYQERDLEPQFSIITKLKGVSVTQIKELGNRLWDVADFVKPPQGENVFFLVTNFLVTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KKGYQERDLEPQFSIITKLKGVSVTQIKELGNRLWDVADFVKPPQGENVFFLVTNFLVTP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 AQVQGRCPEHPSVPLANCWVDEDCPEGEGGTHSHGVKTGQCVVFNGTHRTCEIWSWCPVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AQVQGRCPEHPSVPLANCWVDEDCPEGEGGTHSHGVKTGQCVVFNGTHRTCEIWSWCPVE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 SGVVPSRPLLAQAQNFTLFIKNTVTFSKFNFSKSNALETWDPTYFKHCRYEPQFSPYCPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SGVVPSRPLLAQAQNFTLFIKNTVTFSKFNFSKSNALETWDPTYFKHCRYEPQFSPYCPV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 FRIGDLVAKAGGTFEDLALLGGSVGIRVHWDCDLDTGDSGCWPHYSFQLQEKSYNFRTAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FRIGDLVAKAGGTFEDLALLGGSVGIRVHWDCDLDTGDSGCWPHYSFQLQEKSYNFRTAT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 HWWEQPGVEARTLLKLYGIRFDILVTGQAGKFGLIPTAVTLGTGAAWLGVVTFFCDLLLL ::::::::::::::::::::::::::::: XP_016 HWWEQPGVEARTLLKLYGIRFDILVTGQA------------------------------- 310 320 370 380 390 400 410 420 pF1KE0 YVDREAHFYWRTKYEEAKAPKATANSVWRELALASQARLAECLRRSSAPAPTATAAGSQT ::::::::::::::::::::::::::::::::::::::::::: XP_016 -----------------KAPKATANSVWRELALASQARLAECLRRSSAPAPTATAAGSQT 330 340 350 360 370 430 440 pF1KE0 QTPGWPCPSSDTHLPTHSGSL ::::::::::::::::::::: XP_016 QTPGWPCPSSDTHLPTHSGSL 380 390 >>XP_016884558 (OMIM: 608077) PREDICTED: P2X purinocepto (391 aa) initn: 2432 init1: 2232 opt: 2232 Z-score: 2658.3 bits: 500.8 E(85289): 2.5e-141 Smith-Waterman score: 2641; 88.7% identity (88.7% similar) in 441 aa overlap (1-441:1-391) 10 20 30 40 50 60 pF1KE0 MCPQLAGAGSMGSPGATTGWGLLDYKTEKYVMTRNWRVGALQRLLQFGIVVYVVGWALLA ::::::::::::::::::::::::::::: ::::: XP_016 MCPQLAGAGSMGSPGATTGWGLLDYKTEK--------------------------WALLA 10 20 30 70 80 90 100 110 120 pF1KE0 KKGYQERDLEPQFSIITKLKGVSVTQIKELGNRLWDVADFVKPPQGENVFFLVTNFLVTP ::::::::::::::::::::::::::::::::::::::::::::: XP_016 KKGYQERDLEPQFSIITKLKGVSVTQIKELGNRLWDVADFVKPPQ--------------- 40 50 60 70 130 140 150 160 170 180 pF1KE0 AQVQGRCPEHPSVPLANCWVDEDCPEGEGGTHSHGVKTGQCVVFNGTHRTCEIWSWCPVE ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ---------HPSVPLANCWVDEDCPEGEGGTHSHGVKTGQCVVFNGTHRTCEIWSWCPVE 80 90 100 110 120 130 190 200 210 220 230 240 pF1KE0 SGVVPSRPLLAQAQNFTLFIKNTVTFSKFNFSKSNALETWDPTYFKHCRYEPQFSPYCPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SGVVPSRPLLAQAQNFTLFIKNTVTFSKFNFSKSNALETWDPTYFKHCRYEPQFSPYCPV 140 150 160 170 180 190 250 260 270 280 290 300 pF1KE0 FRIGDLVAKAGGTFEDLALLGGSVGIRVHWDCDLDTGDSGCWPHYSFQLQEKSYNFRTAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FRIGDLVAKAGGTFEDLALLGGSVGIRVHWDCDLDTGDSGCWPHYSFQLQEKSYNFRTAT 200 210 220 230 240 250 310 320 330 340 350 360 pF1KE0 HWWEQPGVEARTLLKLYGIRFDILVTGQAGKFGLIPTAVTLGTGAAWLGVVTFFCDLLLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HWWEQPGVEARTLLKLYGIRFDILVTGQAGKFGLIPTAVTLGTGAAWLGVVTFFCDLLLL 260 270 280 290 300 310 370 380 390 400 410 420 pF1KE0 YVDREAHFYWRTKYEEAKAPKATANSVWRELALASQARLAECLRRSSAPAPTATAAGSQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YVDREAHFYWRTKYEEAKAPKATANSVWRELALASQARLAECLRRSSAPAPTATAAGSQT 320 330 340 350 360 370 430 440 pF1KE0 QTPGWPCPSSDTHLPTHSGSL ::::::::::::::::::::: XP_016 QTPGWPCPSSDTHLPTHSGSL 380 390 >>XP_016884556 (OMIM: 608077) PREDICTED: P2X purinocepto (417 aa) initn: 2232 init1: 2232 opt: 2232 Z-score: 2657.9 bits: 500.9 E(85289): 2.6e-141 Smith-Waterman score: 2875; 94.6% identity (94.6% similar) in 441 aa overlap (1-441:1-417) 10 20 30 40 50 60 pF1KE0 MCPQLAGAGSMGSPGATTGWGLLDYKTEKYVMTRNWRVGALQRLLQFGIVVYVVGWALLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MCPQLAGAGSMGSPGATTGWGLLDYKTEKYVMTRNWRVGALQRLLQFGIVVYVVGWALLA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 KKGYQERDLEPQFSIITKLKGVSVTQIKELGNRLWDVADFVKPPQGENVFFLVTNFLVTP ::::::::::::::::::::::::::::::::::::::::::::: XP_016 KKGYQERDLEPQFSIITKLKGVSVTQIKELGNRLWDVADFVKPPQ--------------- 70 80 90 100 130 140 150 160 170 180 pF1KE0 AQVQGRCPEHPSVPLANCWVDEDCPEGEGGTHSHGVKTGQCVVFNGTHRTCEIWSWCPVE ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ---------HPSVPLANCWVDEDCPEGEGGTHSHGVKTGQCVVFNGTHRTCEIWSWCPVE 110 120 130 140 150 190 200 210 220 230 240 pF1KE0 SGVVPSRPLLAQAQNFTLFIKNTVTFSKFNFSKSNALETWDPTYFKHCRYEPQFSPYCPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SGVVPSRPLLAQAQNFTLFIKNTVTFSKFNFSKSNALETWDPTYFKHCRYEPQFSPYCPV 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE0 FRIGDLVAKAGGTFEDLALLGGSVGIRVHWDCDLDTGDSGCWPHYSFQLQEKSYNFRTAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FRIGDLVAKAGGTFEDLALLGGSVGIRVHWDCDLDTGDSGCWPHYSFQLQEKSYNFRTAT 220 230 240 250 260 270 310 320 330 340 350 360 pF1KE0 HWWEQPGVEARTLLKLYGIRFDILVTGQAGKFGLIPTAVTLGTGAAWLGVVTFFCDLLLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HWWEQPGVEARTLLKLYGIRFDILVTGQAGKFGLIPTAVTLGTGAAWLGVVTFFCDLLLL 280 290 300 310 320 330 370 380 390 400 410 420 pF1KE0 YVDREAHFYWRTKYEEAKAPKATANSVWRELALASQARLAECLRRSSAPAPTATAAGSQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YVDREAHFYWRTKYEEAKAPKATANSVWRELALASQARLAECLRRSSAPAPTATAAGSQT 340 350 360 370 380 390 430 440 pF1KE0 QTPGWPCPSSDTHLPTHSGSL ::::::::::::::::::::: XP_016 QTPGWPCPSSDTHLPTHSGSL 400 410 >>XP_016884564 (OMIM: 608077) PREDICTED: P2X purinocepto (290 aa) initn: 2019 init1: 2019 opt: 2019 Z-score: 2406.5 bits: 453.8 E(85289): 2.6e-127 Smith-Waterman score: 2019; 100.0% identity (100.0% similar) in 287 aa overlap (155-441:4-290) 130 140 150 160 170 180 pF1KE0 GRCPEHPSVPLANCWVDEDCPEGEGGTHSHGVKTGQCVVFNGTHRTCEIWSWCPVESGVV :::::::::::::::::::::::::::::: XP_016 MPRGVKTGQCVVFNGTHRTCEIWSWCPVESGVV 10 20 30 190 200 210 220 230 240 pF1KE0 PSRPLLAQAQNFTLFIKNTVTFSKFNFSKSNALETWDPTYFKHCRYEPQFSPYCPVFRIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSRPLLAQAQNFTLFIKNTVTFSKFNFSKSNALETWDPTYFKHCRYEPQFSPYCPVFRIG 40 50 60 70 80 90 250 260 270 280 290 300 pF1KE0 DLVAKAGGTFEDLALLGGSVGIRVHWDCDLDTGDSGCWPHYSFQLQEKSYNFRTATHWWE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLVAKAGGTFEDLALLGGSVGIRVHWDCDLDTGDSGCWPHYSFQLQEKSYNFRTATHWWE 100 110 120 130 140 150 310 320 330 340 350 360 pF1KE0 QPGVEARTLLKLYGIRFDILVTGQAGKFGLIPTAVTLGTGAAWLGVVTFFCDLLLLYVDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QPGVEARTLLKLYGIRFDILVTGQAGKFGLIPTAVTLGTGAAWLGVVTFFCDLLLLYVDR 160 170 180 190 200 210 370 380 390 400 410 420 pF1KE0 EAHFYWRTKYEEAKAPKATANSVWRELALASQARLAECLRRSSAPAPTATAAGSQTQTPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EAHFYWRTKYEEAKAPKATANSVWRELALASQARLAECLRRSSAPAPTATAAGSQTQTPG 220 230 240 250 260 270 430 440 pF1KE0 WPCPSSDTHLPTHSGSL ::::::::::::::::: XP_016 WPCPSSDTHLPTHSGSL 280 290 >>XP_016884562 (OMIM: 608077) PREDICTED: P2X purinocepto (290 aa) initn: 2019 init1: 2019 opt: 2019 Z-score: 2406.5 bits: 453.8 E(85289): 2.6e-127 Smith-Waterman score: 2019; 100.0% identity (100.0% similar) in 287 aa overlap (155-441:4-290) 130 140 150 160 170 180 pF1KE0 GRCPEHPSVPLANCWVDEDCPEGEGGTHSHGVKTGQCVVFNGTHRTCEIWSWCPVESGVV :::::::::::::::::::::::::::::: XP_016 MPRGVKTGQCVVFNGTHRTCEIWSWCPVESGVV 10 20 30 190 200 210 220 230 240 pF1KE0 PSRPLLAQAQNFTLFIKNTVTFSKFNFSKSNALETWDPTYFKHCRYEPQFSPYCPVFRIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSRPLLAQAQNFTLFIKNTVTFSKFNFSKSNALETWDPTYFKHCRYEPQFSPYCPVFRIG 40 50 60 70 80 90 250 260 270 280 290 300 pF1KE0 DLVAKAGGTFEDLALLGGSVGIRVHWDCDLDTGDSGCWPHYSFQLQEKSYNFRTATHWWE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLVAKAGGTFEDLALLGGSVGIRVHWDCDLDTGDSGCWPHYSFQLQEKSYNFRTATHWWE 100 110 120 130 140 150 310 320 330 340 350 360 pF1KE0 QPGVEARTLLKLYGIRFDILVTGQAGKFGLIPTAVTLGTGAAWLGVVTFFCDLLLLYVDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QPGVEARTLLKLYGIRFDILVTGQAGKFGLIPTAVTLGTGAAWLGVVTFFCDLLLLYVDR 160 170 180 190 200 210 370 380 390 400 410 420 pF1KE0 EAHFYWRTKYEEAKAPKATANSVWRELALASQARLAECLRRSSAPAPTATAAGSQTQTPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EAHFYWRTKYEEAKAPKATANSVWRELALASQARLAECLRRSSAPAPTATAAGSQTQTPG 220 230 240 250 260 270 430 440 pF1KE0 WPCPSSDTHLPTHSGSL ::::::::::::::::: XP_016 WPCPSSDTHLPTHSGSL 280 290 >>XP_016884563 (OMIM: 608077) PREDICTED: P2X purinocepto (290 aa) initn: 2019 init1: 2019 opt: 2019 Z-score: 2406.5 bits: 453.8 E(85289): 2.6e-127 Smith-Waterman score: 2019; 100.0% identity (100.0% similar) in 287 aa overlap (155-441:4-290) 130 140 150 160 170 180 pF1KE0 GRCPEHPSVPLANCWVDEDCPEGEGGTHSHGVKTGQCVVFNGTHRTCEIWSWCPVESGVV :::::::::::::::::::::::::::::: XP_016 MPRGVKTGQCVVFNGTHRTCEIWSWCPVESGVV 10 20 30 190 200 210 220 230 240 pF1KE0 PSRPLLAQAQNFTLFIKNTVTFSKFNFSKSNALETWDPTYFKHCRYEPQFSPYCPVFRIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSRPLLAQAQNFTLFIKNTVTFSKFNFSKSNALETWDPTYFKHCRYEPQFSPYCPVFRIG 40 50 60 70 80 90 250 260 270 280 290 300 pF1KE0 DLVAKAGGTFEDLALLGGSVGIRVHWDCDLDTGDSGCWPHYSFQLQEKSYNFRTATHWWE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLVAKAGGTFEDLALLGGSVGIRVHWDCDLDTGDSGCWPHYSFQLQEKSYNFRTATHWWE 100 110 120 130 140 150 310 320 330 340 350 360 pF1KE0 QPGVEARTLLKLYGIRFDILVTGQAGKFGLIPTAVTLGTGAAWLGVVTFFCDLLLLYVDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QPGVEARTLLKLYGIRFDILVTGQAGKFGLIPTAVTLGTGAAWLGVVTFFCDLLLLYVDR 160 170 180 190 200 210 370 380 390 400 410 420 pF1KE0 EAHFYWRTKYEEAKAPKATANSVWRELALASQARLAECLRRSSAPAPTATAAGSQTQTPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EAHFYWRTKYEEAKAPKATANSVWRELALASQARLAECLRRSSAPAPTATAAGSQTQTPG 220 230 240 250 260 270 430 440 pF1KE0 WPCPSSDTHLPTHSGSL ::::::::::::::::: XP_016 WPCPSSDTHLPTHSGSL 280 290 >>XP_016884565 (OMIM: 608077) PREDICTED: P2X purinocepto (290 aa) initn: 2019 init1: 2019 opt: 2019 Z-score: 2406.5 bits: 453.8 E(85289): 2.6e-127 Smith-Waterman score: 2019; 100.0% identity (100.0% similar) in 287 aa overlap (155-441:4-290) 130 140 150 160 170 180 pF1KE0 GRCPEHPSVPLANCWVDEDCPEGEGGTHSHGVKTGQCVVFNGTHRTCEIWSWCPVESGVV :::::::::::::::::::::::::::::: XP_016 MPRGVKTGQCVVFNGTHRTCEIWSWCPVESGVV 10 20 30 190 200 210 220 230 240 pF1KE0 PSRPLLAQAQNFTLFIKNTVTFSKFNFSKSNALETWDPTYFKHCRYEPQFSPYCPVFRIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSRPLLAQAQNFTLFIKNTVTFSKFNFSKSNALETWDPTYFKHCRYEPQFSPYCPVFRIG 40 50 60 70 80 90 250 260 270 280 290 300 pF1KE0 DLVAKAGGTFEDLALLGGSVGIRVHWDCDLDTGDSGCWPHYSFQLQEKSYNFRTATHWWE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLVAKAGGTFEDLALLGGSVGIRVHWDCDLDTGDSGCWPHYSFQLQEKSYNFRTATHWWE 100 110 120 130 140 150 310 320 330 340 350 360 pF1KE0 QPGVEARTLLKLYGIRFDILVTGQAGKFGLIPTAVTLGTGAAWLGVVTFFCDLLLLYVDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QPGVEARTLLKLYGIRFDILVTGQAGKFGLIPTAVTLGTGAAWLGVVTFFCDLLLLYVDR 160 170 180 190 200 210 370 380 390 400 410 420 pF1KE0 EAHFYWRTKYEEAKAPKATANSVWRELALASQARLAECLRRSSAPAPTATAAGSQTQTPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EAHFYWRTKYEEAKAPKATANSVWRELALASQARLAECLRRSSAPAPTATAAGSQTQTPG 220 230 240 250 260 270 430 440 pF1KE0 WPCPSSDTHLPTHSGSL ::::::::::::::::: XP_016 WPCPSSDTHLPTHSGSL 280 290 441 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 00:51:32 2016 done: Thu Nov 3 00:51:33 2016 Total Scan time: 9.280 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]