FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0544, 427 aa 1>>>pF1KE0544 427 - 427 aa - 427 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.7551+/-0.000886; mu= 14.1493+/- 0.053 mean_var=62.7989+/-12.417, 0's: 0 Z-trim(105.5): 18 B-trim: 0 in 0/49 Lambda= 0.161845 statistics sampled from 8446 (8452) to 8446 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.641), E-opt: 0.2 (0.26), width: 16 Scan time: 2.620 The best scores are: opt bits E(32554) CCDS13881.1 TCN2 gene_id:6948|Hs108|chr22 ( 427) 2837 671.2 5.2e-193 CCDS54519.1 TCN2 gene_id:6948|Hs108|chr22 ( 400) 1877 447.1 1.5e-125 CCDS7978.1 TCN1 gene_id:6947|Hs108|chr11 ( 433) 452 114.4 2.3e-25 CCDS7977.1 GIF gene_id:2694|Hs108|chr11 ( 417) 261 69.8 5.8e-12 >>CCDS13881.1 TCN2 gene_id:6948|Hs108|chr22 (427 aa) initn: 2837 init1: 2837 opt: 2837 Z-score: 3578.7 bits: 671.2 E(32554): 5.2e-193 Smith-Waterman score: 2837; 99.8% identity (99.8% similar) in 427 aa overlap (1-427:1-427) 10 20 30 40 50 60 pF1KE0 MRHLGAFLFLLGVLGALTEMCEIPEMDSHLVEKLGQHLLPWMDRLSLEHLNPSIYVGLRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 MRHLGAFLFLLGVLGALTEMCEIPEMDSHLVEKLGQHLLPWMDRLSLEHLNPSIYVGLRL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 SSLQAGTKEDLYLHSLKLGYQQCLLGSAFSEDDGDCQGKPSMGQLALYLLALRANCEFVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 SSLQAGTKEDLYLHSLKLGYQQCLLGSAFSEDDGDCQGKPSMGQLALYLLALRANCEFVR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 GHKGDRLVSQLKWFLEDEKRAIGHDHKGHPHTSYYQYGLGILALCLHQKRVHDSVVDKLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 GHKGDRLVSQLKWFLEDEKRAIGHDHKGHPHTSYYQYGLGILALCLHQKRVHDSVVDKLL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 YAVEPFHQGHHSVDTAAMAGLAFTCLKRSNFNPGRRQRITMAIRTVREEILKAQTPEGHF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 YAVEPFHQGHHSVDTAAMAGLAFTCLKRSNFNPGRRQRITMAIRTVREEILKAQTPEGHF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 GNVYSTPLALQFLMTSPMPGAELGTACLKARVALLASLQDGAFQNALMISQLLPVLNHKT :::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::: CCDS13 GNVYSTPLALQFLMTSPMRGAELGTACLKARVALLASLQDGAFQNALMISQLLPVLNHKT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 YIDLIFPDCLAPRVMLEPAAETIPQTQEIISVTLQVLSLLPPYRQSISVLAGSTVEDVLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 YIDLIFPDCLAPRVMLEPAAETIPQTQEIISVTLQVLSLLPPYRQSISVLAGSTVEDVLK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 KAHELGGFTYETQASLSGPYLTSVMGKAAGEREFWQLLRDPNTPLLQGIADYRPKDGETI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 KAHELGGFTYETQASLSGPYLTSVMGKAAGEREFWQLLRDPNTPLLQGIADYRPKDGETI 370 380 390 400 410 420 pF1KE0 ELRLVSW ::::::: CCDS13 ELRLVSW >>CCDS54519.1 TCN2 gene_id:6948|Hs108|chr22 (400 aa) initn: 1874 init1: 1874 opt: 1877 Z-score: 2367.7 bits: 447.1 E(32554): 1.5e-125 Smith-Waterman score: 2580; 93.4% identity (93.4% similar) in 427 aa overlap (1-427:1-400) 10 20 30 40 50 60 pF1KE0 MRHLGAFLFLLGVLGALTEMCEIPEMDSHLVEKLGQHLLPWMDRLSLEHLNPSIYVGLRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS54 MRHLGAFLFLLGVLGALTEMCEIPEMDSHLVEKLGQHLLPWMDRLSLEHLNPSIYVGLRL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 SSLQAGTKEDLYLHSLKLGYQQCLLGSAFSEDDGDCQGKPSMGQLALYLLALRANCEFVR ::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS54 SSLQAGTKEDLYLHSLKLGYQQCLLGSAFSEDDGDCQGKPSMGQLALYLLALRAN----- 70 80 90 100 110 130 140 150 160 170 180 pF1KE0 GHKGDRLVSQLKWFLEDEKRAIGHDHKGHPHTSYYQYGLGILALCLHQKRVHDSVVDKLL : ::::::::::::::::::::::::::::::::::::: CCDS54 ------------W----------HDHKGHPHTSYYQYGLGILALCLHQKRVHDSVVDKLL 120 130 140 150 190 200 210 220 230 240 pF1KE0 YAVEPFHQGHHSVDTAAMAGLAFTCLKRSNFNPGRRQRITMAIRTVREEILKAQTPEGHF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS54 YAVEPFHQGHHSVDTAAMAGLAFTCLKRSNFNPGRRQRITMAIRTVREEILKAQTPEGHF 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE0 GNVYSTPLALQFLMTSPMPGAELGTACLKARVALLASLQDGAFQNALMISQLLPVLNHKT :::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::: CCDS54 GNVYSTPLALQFLMTSPMRGAELGTACLKARVALLASLQDGAFQNALMISQLLPVLNHKT 220 230 240 250 260 270 310 320 330 340 350 360 pF1KE0 YIDLIFPDCLAPRVMLEPAAETIPQTQEIISVTLQVLSLLPPYRQSISVLAGSTVEDVLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS54 YIDLIFPDCLAPRVMLEPAAETIPQTQEIISVTLQVLSLLPPYRQSISVLAGSTVEDVLK 280 290 300 310 320 330 370 380 390 400 410 420 pF1KE0 KAHELGGFTYETQASLSGPYLTSVMGKAAGEREFWQLLRDPNTPLLQGIADYRPKDGETI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS54 KAHELGGFTYETQASLSGPYLTSVMGKAAGEREFWQLLRDPNTPLLQGIADYRPKDGETI 340 350 360 370 380 390 pF1KE0 ELRLVSW ::::::: CCDS54 ELRLVSW 400 >>CCDS7978.1 TCN1 gene_id:6947|Hs108|chr11 (433 aa) initn: 389 init1: 132 opt: 452 Z-score: 568.9 bits: 114.4 E(32554): 2.3e-25 Smith-Waterman score: 484; 29.4% identity (59.0% similar) in 446 aa overlap (4-423:10-429) 10 20 30 40 50 pF1KE0 MRHLGAFLFLLGVLGALTEMCEIPEMDSHLVEKLGQHLLPWMDRLSLEHLNPSI .: .:: . . . : :.::. : . .. : . .. . .: . CCDS79 MRQSHQLPLVGLLLFSF-IPSQLCEICEVSEENYIRLKPLLNTMIQSNYNRGTSAVN--V 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 YVGLRLSSLQAGTKEDLYLHSLKLGYQQCLLGSAFSEDDGDCQGKPSMGQLALYLLAL-- ..:.: ..: : . .....: . .. : .: : :.::: .::: CCDS79 VLSLKLVGIQIQTLMQKMIQQIKYNVKSRL---------SDV----SSGELALIILALGV 60 70 80 90 100 120 130 140 150 160 pF1KE0 --RANCEFVRG-HKGDRLVSQLKWFLEDEKRAIGHDHKGHPHTSYYQYGLGILALCLHQK :. ... : :.: .... .:. . :.: : :.::: .: .::::: . CCDS79 CRNAEENLIYDYHLIDKLENKFQAEIENMEA-----HNGTPLTNYYQLSLDVLALCLFNG 110 120 130 140 150 170 180 190 200 210 220 pF1KE0 RVHDS-VVDKLLYAVEPFHQGHH-SVDTAAMAGLAFTCLKRSNFN------PGRRQRITM . ::... . .. : . ::::.::: ::.::.:.: .: : . :.. CCDS79 NYSTAEVVNHFTPENKNYYFGSQFSVDTGAMAVLALTCVKKSLINGQIKADEGSLKNISI 160 170 180 190 200 210 230 240 250 260 270 280 pF1KE0 AIRTVREEILKAQTPEGHFGNVYSTPLALQFLMTSPMPGAELGTACLKARVALLASLQDG ... :.::. . .: .::..:: :.: :..: : : .. ..:. ...: CCDS79 YTKSLVEKILSEKKENGLIGNTFSTGEAMQALFVSSDYYNENDWNCQQTLNTVLTEISQG 220 230 240 250 260 270 290 300 310 320 330 pF1KE0 AFQNALMISQLLPVLNHKTYIDLIFPD--CLAPRVML-----EPAAETIPQTQEIISVTL ::.: .:.::.: ::..: : : :.. . :: . : :..: :::. CCDS79 AFSNPNAAAQVLPALMGKTFLD-INKDSSCVSASGNFNISADEPITVTPPDSQSYISVNY 280 290 300 310 320 330 340 350 360 370 380 390 pF1KE0 QVLSLLPPYRQSISVLAGSTVEDVLKKAHELG----GFTYETQASLSGPYLTSVMGKAAG .: . : ...:: ::. .:..::.... :::.: .. :::.: ..: :. CCDS79 SV-RINETYFTNVTVLNGSVFLSVMEKAQKMNDTIFGFTMEERS--WGPYITCIQGLCAN 340 350 360 370 380 390 400 410 420 pF1KE0 --EREFWQLLRDPNTPLLQGIADYRPKDGETIELRLVSW .: .:.:: . . :: :: ..: ..::..:.: CCDS79 NNDRTYWELL-SGGEPLSQGAGSYVVRNGENLEVRWSKY 400 410 420 430 >>CCDS7977.1 GIF gene_id:2694|Hs108|chr11 (417 aa) initn: 193 init1: 65 opt: 261 Z-score: 328.2 bits: 69.8 E(32554): 5.8e-12 Smith-Waterman score: 405; 28.2% identity (56.4% similar) in 440 aa overlap (8-420:6-410) 10 20 30 40 50 pF1KE0 MRHLGAFLFLLGVL----GALTEM---CEIPEMDSHLVEKLGQHLLPWMDRLSLEHLNPS :.::..: :. :. : .: . ::. : ..: . : . ::: CCDS79 MAWFALYLLSLLWATAGTSTQTQSSCSVPSAQEPLVN--GIQVLMENSVTSSAYPNPS 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 IYVGLRLSSLQAGTKEDLYLHSLKLGYQQCLLGSAFSEDDGDCQGKPSMGQLALYLLALR : ... : ::. ..:: :. : . .: :..: ..:::.: ..:: CCDS79 ILIAMNL----AGA------YNLKA--QKLLTYQLMSSDNNDL----TIGQLGLTIMALT 60 70 80 90 100 120 130 140 150 160 170 pF1KE0 ANCEFVRGHKGDRLVSQLKWFLEDEKRAIGHDHKGHPHTSYYQYGLGILALCLHQKRVHD ..:. ::. :: :. .:. . . . ...: .:.::::: ..... CCDS79 SSCR----DPGDK-VSILQRQMEN----WAPSSPNAEASAFYGPSLAILALCQKNSEATL 110 120 130 140 150 180 190 200 210 220 pF1KE0 SVVDK----LLYAVEPFHQGHHSVDTAAMAGLAFTCLKRS---NFNPGRRQRITMAIRTV .. . :: ::. :::.::: ::.::. . . . : :. . .... . CCDS79 PIAVRFAKTLLANSSPFN-----VDTGAMATLALTCMYNKIPVGSEEGYRSLFGQVLKDI 160 170 180 190 200 230 240 250 260 270 280 pF1KE0 REEILKAQTPEGHFGNVYSTPLALQFLMTSPMPGAELGTACLKARVALLASLQDGAFQNA :.: .: .:..::: ::.: : ..: :. . . : :. .: ...: :.: CCDS79 VEKISMKIKDNGIIGDIYSTGLAMQALSVTPEPSKKEWN-CKKTTDMILNEIKQGKFHNP 210 220 230 240 250 260 290 300 310 320 330 pF1KE0 LMISQLLPVLNHKTYIDLIFPDCLAPRVMLEPAAETIP----QTQEIISVTLQV------ . :.:.:: :. :::.:. : .: ..:. . : . :.: . CCDS79 MSIAQILPSLKGKTYLDVPQVTC-SPDHEVQPTLPSNPGPGPTSASNITVIYTINNQLRG 270 280 290 300 310 320 340 350 360 370 380 390 pF1KE0 LSLLPPYRQSISVLAGSTVEDVLKKAHELGG-FTYETQASLSGPYLTSV--MGKAAGERE . :: ..:: .::.. ::..:.. . : .:: . : ..:. ... .... CCDS79 VELLFNETINVSVKSGSVLLVVLEEAQRKNPMFKFETTMTSWGLVVSSINNIAENVNHKT 330 340 350 360 370 380 400 410 420 pF1KE0 FWQLLRDPNTPLLQGIADYRPKDGETIELRLVSW .::.: ::: .:.::: : . : : CCDS79 YWQFLSGV-TPLNEGVADYIPFNHEHITANFTQY 390 400 410 427 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 00:04:58 2016 done: Thu Nov 3 00:04:58 2016 Total Scan time: 2.620 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]