FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0570, 246 aa 1>>>pF1KE0570 246 - 246 aa - 246 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1424+/-0.000692; mu= 15.2806+/- 0.041 mean_var=66.9412+/-13.667, 0's: 0 Z-trim(109.9): 39 B-trim: 0 in 0/48 Lambda= 0.156757 statistics sampled from 11160 (11199) to 11160 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.735), E-opt: 0.2 (0.344), width: 16 Scan time: 2.200 The best scores are: opt bits E(32554) CCDS5224.1 RAET1L gene_id:154064|Hs108|chr6 ( 246) 1701 393.1 9.2e-110 CCDS5222.1 ULBP2 gene_id:80328|Hs108|chr6 ( 246) 1593 368.7 2.1e-102 CCDS43514.1 RAET1G gene_id:353091|Hs108|chr6 ( 334) 1445 335.3 3.2e-92 CCDS5223.1 ULBP1 gene_id:80329|Hs108|chr6 ( 244) 1003 235.2 3e-62 CCDS5225.1 ULBP3 gene_id:79465|Hs108|chr6 ( 244) 823 194.5 5.4e-50 CCDS5221.1 RAET1E gene_id:135250|Hs108|chr6 ( 263) 438 107.5 9.4e-24 CCDS59042.1 RAET1E gene_id:135250|Hs108|chr6 ( 209) 433 106.3 1.7e-23 CCDS59043.1 RAET1E gene_id:135250|Hs108|chr6 ( 212) 433 106.3 1.7e-23 CCDS59044.1 RAET1E gene_id:135250|Hs108|chr6 ( 227) 337 84.6 6.2e-17 CCDS75412.1 HFE gene_id:3077|Hs108|chr6 ( 337) 253 65.7 4.5e-11 CCDS4578.1 HFE gene_id:3077|Hs108|chr6 ( 348) 253 65.7 4.6e-11 >>CCDS5224.1 RAET1L gene_id:154064|Hs108|chr6 (246 aa) initn: 1701 init1: 1701 opt: 1701 Z-score: 2084.1 bits: 393.1 E(32554): 9.2e-110 Smith-Waterman score: 1701; 100.0% identity (100.0% similar) in 246 aa overlap (1-246:1-246) 10 20 30 40 50 60 pF1KE0 MAAAAIPALLLCLPLLFLLFGWSRARRDDPHSLCYDITVIPKFRPGPRWCAVQGQVDEKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS52 MAAAAIPALLLCLPLLFLLFGWSRARRDDPHSLCYDITVIPKFRPGPRWCAVQGQVDEKT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 FLHYDCGNKTVTPVSPLGKKLNVTMAWKAQNPVLREVVDILTEQLLDIQLENYTPKEPLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS52 FLHYDCGNKTVTPVSPLGKKLNVTMAWKAQNPVLREVVDILTEQLLDIQLENYTPKEPLT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 LQARMSCEQKAEGHSSGSWQFSIDGQTFLLFDSEKRMWTTVHPGARKMKEKWENDKDVAM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS52 LQARMSCEQKAEGHSSGSWQFSIDGQTFLLFDSEKRMWTTVHPGARKMKEKWENDKDVAM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 SFHYISMGDCIGWLEDFLMGMDSTLEPSAGAPLAMSSGTTQLRATATTLILCCLLIILPC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS52 SFHYISMGDCIGWLEDFLMGMDSTLEPSAGAPLAMSSGTTQLRATATTLILCCLLIILPC 190 200 210 220 230 240 pF1KE0 FILPGI :::::: CCDS52 FILPGI >>CCDS5222.1 ULBP2 gene_id:80328|Hs108|chr6 (246 aa) initn: 1593 init1: 1593 opt: 1593 Z-score: 1952.1 bits: 368.7 E(32554): 2.1e-102 Smith-Waterman score: 1593; 94.3% identity (95.9% similar) in 246 aa overlap (1-246:1-246) 10 20 30 40 50 60 pF1KE0 MAAAAIPALLLCLPLLFLLFGWSRARRDDPHSLCYDITVIPKFRPGPRWCAVQGQVDEKT ::::: .:::::::.:: ::::: : :::::::::::::::::::::::::::::::: CCDS52 MAAAAATKILLCLPLLLLLSGWSRAGRADPHSLCYDITVIPKFRPGPRWCAVQGQVDEKT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 FLHYDCGNKTVTPVSPLGKKLNVTMAWKAQNPVLREVVDILTEQLLDIQLENYTPKEPLT :::::::::::::::::::::::: :::::::::::::::::::: :::::::::::::: CCDS52 FLHYDCGNKTVTPVSPLGKKLNVTTAWKAQNPVLREVVDILTEQLRDIQLENYTPKEPLT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 LQARMSCEQKAEGHSSGSWQFSIDGQTFLLFDSEKRMWTTVHPGARKMKEKWENDKDVAM ::::::::::::::::::::::.::: ::::::::::::::::::::::::::::: ::: CCDS52 LQARMSCEQKAEGHSSGSWQFSFDGQIFLLFDSEKRMWTTVHPGARKMKEKWENDKVVAM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 SFHYISMGDCIGWLEDFLMGMDSTLEPSAGAPLAMSSGTTQLRATATTLILCCLLIILPC ::::.::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS52 SFHYFSMGDCIGWLEDFLMGMDSTLEPSAGAPLAMSSGTTQLRATATTLILCCLLIILPC 190 200 210 220 230 240 pF1KE0 FILPGI :::::: CCDS52 FILPGI >>CCDS43514.1 RAET1G gene_id:353091|Hs108|chr6 (334 aa) initn: 1463 init1: 1441 opt: 1445 Z-score: 1769.2 bits: 335.3 E(32554): 3.2e-92 Smith-Waterman score: 1445; 86.8% identity (93.8% similar) in 243 aa overlap (1-243:1-241) 10 20 30 40 50 60 pF1KE0 MAAAAIPALLLCLPLLFLLFGWSRARRDDPHSLCYDITVIPKFRPGPRWCAVQGQVDEKT ::::: ::.:: ::::.:: .: :. :::::::::::::::::::::::::::::::: CCDS43 MAAAASPAFLLRLPLLLLLSSWCRTGLADPHSLCYDITVIPKFRPGPRWCAVQGQVDEKT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 FLHYDCGNKTVTPVSPLGKKLNVTMAWKAQNPVLREVVDILTEQLLDIQLENYTPKEPLT :::::::.:::::::::::::::: :::::::::::::::::::::::::::: :::::: CCDS43 FLHYDCGSKTVTPVSPLGKKLNVTTAWKAQNPVLREVVDILTEQLLDIQLENYIPKEPLT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 LQARMSCEQKAEGHSSGSWQFSIDGQTFLLFDSEKRMWTTVHPGARKMKEKWENDKDVAM ::::::::::::::.:::::.:.::: :::::::.::::::::::::::::::::::..: CCDS43 LQARMSCEQKAEGHGSGSWQLSFDGQIFLLFDSENRMWTTVHPGARKMKEKWENDKDMTM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 SFHYISMGDCIGWLEDFLMGMDSTLEPSAGAPLAMSSGTTQLRATATTLILCCLLIILPC :::::::::: ::::::::::::::::::::: .:::::.: ::::::::::::::. : CCDS43 SFHYISMGDCTGWLEDFLMGMDSTLEPSAGAPPTMSSGTAQPRATATTLILCCLLIM--C 190 200 210 220 230 pF1KE0 FILPGI ... CCDS43 LLICSRHSLTQSHGHHPQSLQPPPHPPLLHPTWLLRRVLWSDSYQIAKRPLSGGHVTRVT 240 250 260 270 280 290 >>CCDS5223.1 ULBP1 gene_id:80329|Hs108|chr6 (244 aa) initn: 1027 init1: 927 opt: 1003 Z-score: 1231.0 bits: 235.2 E(32554): 3e-62 Smith-Waterman score: 1003; 60.4% identity (78.0% similar) in 245 aa overlap (1-245:1-243) 10 20 30 40 50 60 pF1KE0 MAAAAIPALLLCLPLLFLLFGWSRARRDDPHSLCYDITVIPKFRPGPRWCAVQGQVDEKT ::::: ::.::::::: :: ::::: : : ::::. . :: :: :.:: ::: :::. CCDS52 MAAAASPAFLLCLPLLHLLSGWSRAGWVDTHCLCYDFIITPKSRPEPQWCEVQGLVDERP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 FLHYDCGNKTVTPVSPLGKKLNVTMAWKAQNPVLREVVDILTEQLLDIQLENYTPKEPLT :::::: :. . . ::::.::: .:. :. .::.:::.: ::::::.:: : :::: CCDS52 FLHYDCVNHKAKAFASLGKKVNVTKTWEEQTETLRDVVDFLKGQLLDIQVENLIPIEPLT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 LQARMSCEQKAEGHSSGSWQFSIDGQTFLLFDSEKRMWTTVHPGARKMKEKWENDKDVAM ::::::::..:.::. ::::: ..:: ::::::..: ::..::::.:: ::::...::.: CCDS52 LQARMSCEHEAHGHGRGSWQFLFNGQKFLLFDSNNRKWTALHPGAKKMTEKWEKNRDVTM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 SFHYISMGDCIGWLEDFLMGMDSTLEPSAGAPLAMSSGTTQLRATATTLILCCLLIILPC :. ::.::: :::.::: .. :.:. : ... :::: .: :::: ::::. : CCDS52 FFQKISLGDCKMWLEEFLMYWEQMLDPT--KPPSLAPGTTQPKAMATTLSPWSLLIIFLC 190 200 210 220 230 pF1KE0 FILPGI ::: : CCDS52 FILAGR 240 >>CCDS5225.1 ULBP3 gene_id:79465|Hs108|chr6 (244 aa) initn: 753 init1: 707 opt: 823 Z-score: 1011.0 bits: 194.5 E(32554): 5.4e-50 Smith-Waterman score: 823; 53.8% identity (74.1% similar) in 247 aa overlap (1-246:1-244) 10 20 30 40 50 pF1KE0 MAAAAIPALLLCLPLL-FLLFGWSRARRDDPHSLCYDITVIPKFRPGPRWCAVQGQVDEK ::::: ::.: : .: .::: :: . : : ::: :..:.: : : .:: ::.:::.: CCDS52 MAAAASPAILPRLAILPYLLFDWSGTGRADAHSLWYNFTIIHLPRHGQQWCEVQSQVDQK 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE0 TFLHYDCGNKTVTPVSPLGKKLNVTMAWKAQNPVLREVVDILTEQLLDIQLENYTPKEPL .:: ::::. : .. : ..: .: :: : .:::: . : .: : .::..::. :: CCDS52 NFLSYDCGSDKVLSMGHLEEQLYATDAWGKQLEMLREVGQRLRLELADTELEDFTPSGPL 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE0 TLQARMSCEQKAEGHSSGSWQFSIDGQTFLLFDSEKRMWTTVHPGARKMKEKWENDKDVA :::.::::: .:.:. ::::::.::. ::::::..: ::.:: :::.::::::.:. .. CCDS52 TLQVRMSCECEADGYIRGSWQFSFDGRKFLLFDSNNRKWTVVHAGARRMKEKWEKDSGLT 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE0 MSFHYISMGDCIGWLEDFLMGMDSTLEPSAGAPLAMSSGTTQLRATATTLILCCLLIILP :...:: :: .::.:::: . :::.: : .:. : .: .: :::: .:::: CCDS52 TFFKMVSMRDCKSWLRDFLMHRKKRLEPTA--PPTMAPGLAQPKAIATTLSPWSFLIIL- 190 200 210 220 230 240 pF1KE0 CFILPGI ::::::: CCDS52 CFILPGI 240 >>CCDS5221.1 RAET1E gene_id:135250|Hs108|chr6 (263 aa) initn: 433 init1: 263 opt: 438 Z-score: 540.0 bits: 107.5 E(32554): 9.4e-24 Smith-Waterman score: 438; 34.3% identity (63.4% similar) in 216 aa overlap (31-240:31-245) 10 20 30 40 50 60 pF1KE0 MAAAAIPALLLCLPLLFLLFGWSRARRDDPHSLCYDITVIPKFRPGPRWCAVQGQVDEKT ::::...:. ::: :: .: .... CCDS52 MRRISLTSSPVRLLLFLLLLLIALEIMVGGHSLCFNFTIKSLSRPGQPWCEAQVFLNKNL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 FLHYDCGNKTVTPVSPLGKKLNVTMAWKAQNPVLREVVDILTEQLLDIQLENYTPKEPLT ::.:. :. : :.. ::::. .: .: . .: :: : : ::. . : ..: : CCDS52 FLQYNSDNNMVKPLGLLGKKVYATSTWGELTQTLGEVGRDLRMLLCDIKPQIKT-SDPST 70 80 90 100 110 130 140 150 160 170 180 pF1KE0 LQARMSCEQKAEGHSSGSWQFSIDGQTFLLFDSEKRMWTTVHPGARKMKEKWENDKDVAM ::..: :...:: ...::::. .:. ::::. . ::... : :.:: :..:. . CCDS52 LQVEMFCQREAERCTGASWQFATNGEKSLLFDAMNMTWTVINHEASKIKETWKKDRGLEK 120 130 140 150 160 170 190 200 210 220 230 pF1KE0 SFHYISMGDCIGWLEDFLMGMDSTLEPSAG----APLAMSSGTTQLR--ATATTLILCCL :. .: ::: ::..:: .. ::... . . ::.. : .. ..: . CCDS52 YFRKLSKGDCDHWLREFLGHWEAMPEPTVSPVNASDIHWSSSSLPDRWIILGAFILLVLM 180 190 200 210 220 230 240 pF1KE0 LIILPCFILPGI :.: : CCDS52 GIVLICVWWQNGEWQAGLWPLRTS 240 250 260 >>CCDS59042.1 RAET1E gene_id:135250|Hs108|chr6 (209 aa) initn: 433 init1: 263 opt: 433 Z-score: 535.3 bits: 106.3 E(32554): 1.7e-23 Smith-Waterman score: 433; 37.6% identity (66.3% similar) in 178 aa overlap (31-208:31-207) 10 20 30 40 50 60 pF1KE0 MAAAAIPALLLCLPLLFLLFGWSRARRDDPHSLCYDITVIPKFRPGPRWCAVQGQVDEKT ::::...:. ::: :: .: .... CCDS59 MRRISLTSSPVRLLLFLLLLLIALEIMVGGHSLCFNFTIKSLSRPGQPWCEAQVFLNKNL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 FLHYDCGNKTVTPVSPLGKKLNVTMAWKAQNPVLREVVDILTEQLLDIQLENYTPKEPLT ::.:. :. : :.. ::::. .: .: . .: :: : : ::. . : ..: : CCDS59 FLQYNSDNNMVKPLGLLGKKVYATSTWGELTQTLGEVGRDLRMLLCDIKPQIKT-SDPST 70 80 90 100 110 130 140 150 160 170 180 pF1KE0 LQARMSCEQKAEGHSSGSWQFSIDGQTFLLFDSEKRMWTTVHPGARKMKEKWENDKDVAM ::..: :...:: ...::::. .:. ::::. . ::... : :.:: :..:. . CCDS59 LQVEMFCQREAERCTGASWQFATNGEKSLLFDAMNMTWTVINHEASKIKETWKKDRGLEK 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE0 SFHYISMGDCIGWLEDFLMGMDSTLEPSAGAPLAMSSGTTQLRATATTLILCCLLIILPC :. .: ::: ::..:: .. ::. CCDS59 YFRKLSKGDCDHWLREFLGHWEAMPEPTGN 180 190 200 >>CCDS59043.1 RAET1E gene_id:135250|Hs108|chr6 (212 aa) initn: 433 init1: 263 opt: 433 Z-score: 535.2 bits: 106.3 E(32554): 1.7e-23 Smith-Waterman score: 433; 37.6% identity (66.3% similar) in 178 aa overlap (31-208:31-207) 10 20 30 40 50 60 pF1KE0 MAAAAIPALLLCLPLLFLLFGWSRARRDDPHSLCYDITVIPKFRPGPRWCAVQGQVDEKT ::::...:. ::: :: .: .... CCDS59 MRRISLTSSPVRLLLFLLLLLIALEIMVGGHSLCFNFTIKSLSRPGQPWCEAQVFLNKNL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 FLHYDCGNKTVTPVSPLGKKLNVTMAWKAQNPVLREVVDILTEQLLDIQLENYTPKEPLT ::.:. :. : :.. ::::. .: .: . .: :: : : ::. . : ..: : CCDS59 FLQYNSDNNMVKPLGLLGKKVYATSTWGELTQTLGEVGRDLRMLLCDIKPQIKT-SDPST 70 80 90 100 110 130 140 150 160 170 180 pF1KE0 LQARMSCEQKAEGHSSGSWQFSIDGQTFLLFDSEKRMWTTVHPGARKMKEKWENDKDVAM ::..: :...:: ...::::. .:. ::::. . ::... : :.:: :..:. . CCDS59 LQVEMFCQREAERCTGASWQFATNGEKSLLFDAMNMTWTVINHEASKIKETWKKDRGLEK 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE0 SFHYISMGDCIGWLEDFLMGMDSTLEPSAGAPLAMSSGTTQLRATATTLILCCLLIILPC :. .: ::: ::..:: .. ::. CCDS59 YFRKLSKGDCDHWLREFLGHWEAMPEPTGRRST 180 190 200 210 >>CCDS59044.1 RAET1E gene_id:135250|Hs108|chr6 (227 aa) initn: 322 init1: 263 opt: 337 Z-score: 417.4 bits: 84.6 E(32554): 6.2e-17 Smith-Waterman score: 337; 33.0% identity (62.2% similar) in 185 aa overlap (62-240:26-209) 40 50 60 70 80 90 pF1KE0 SLCYDITVIPKFRPGPRWCAVQGQVDEKTFLHYDCGNKTVTPVSPLGKKLNVTMAWKAQN . :. :. : :.. ::::. .: .: . CCDS59 MRRISLTSSPVRLLLFLLLLLIALEIMYNSDNNMVKPLGLLGKKVYATSTWGELT 10 20 30 40 50 100 110 120 130 140 150 pF1KE0 PVLREVVDILTEQLLDIQLENYTPKEPLTLQARMSCEQKAEGHSSGSWQFSIDGQTFLLF .: :: : : ::. . : ..: :::..: :...:: ...::::. .:. ::: CCDS59 QTLGEVGRDLRMLLCDIKPQIKT-SDPSTLQVEMFCQREAERCTGASWQFATNGEKSLLF 60 70 80 90 100 110 160 170 180 190 200 210 pF1KE0 DSEKRMWTTVHPGARKMKEKWENDKDVAMSFHYISMGDCIGWLEDFLMGMDSTLEPSAG- :. . ::... : :.:: :..:. . :. .: ::: ::..:: .. ::... CCDS59 DAMNMTWTVINHEASKIKETWKKDRGLEKYFRKLSKGDCDHWLREFLGHWEAMPEPTVSP 120 130 140 150 160 170 220 230 240 pF1KE0 ---APLAMSSGTTQLR--ATATTLILCCLLIILPCFILPGI . . ::.. : .. ..: . :.: : CCDS59 VNASDIHWSSSSLPDRWIILGAFILLVLMGIVLICVWWQNGEWQAGLWPLRTS 180 190 200 210 220 >>CCDS75412.1 HFE gene_id:3077|Hs108|chr6 (337 aa) initn: 255 init1: 213 opt: 253 Z-score: 312.3 bits: 65.7 E(32554): 4.5e-11 Smith-Waterman score: 253; 27.7% identity (53.7% similar) in 231 aa overlap (1-226:1-227) 10 20 30 40 50 60 pF1KE0 MAAAAIPALLLCLPLLFLLFGWSRARRDDPHSLCYDITVIPKFRPGPRWCAVQGQVDEKT :. : ::::: :..: . ..: ::: : . . : . : ::.. CCDS75 MGPRARPALLL---LMLLQTAVLQGRLLRSHSLHYLFMGASEQDLGLSLFEALGYVDDQL 10 20 30 40 50 70 80 90 100 110 pF1KE0 FLHYDCGNKTVTPVSPLGKKLNVTMAWKAQNPVLREVVDILTEQLLDIQLENYT-PKEPL :. :: .. : : .: .. .. : . :. ..: .. : .::.. :: CCDS75 FVFYDHESRRVEPRTPWVSSRISSQMWLQLSQSLKGWDHMFTVDFWTI-MENHNHSKESH 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 TLQARMSCEQKAEGHSSGSWQFSIDGQTFLLFDSEKRMWTTVHPGARKMKEKWENDKDVA :::. ..::.. .. . : :... ::: : : . : ...: : : .:: : : CCDS75 TLQVILGCEMQEDNSTEGYWKYGYDGQDHLEFCPDTLDWRAAEPRAWPTKLEWERHKIRA 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE0 MSFHYISMGDCIGWLEDFL-MG---MDSTLEPSAGAPLAMSSGTTQLRATATTLILCCLL . . :: . :...: .: .:. . : . . ..:..: :: : CCDS75 RQNRAYLERDCPAQLQQLLELGRGVLDQQVPPLVKVTHHVTSSVTTLRCRALNYYPQNIT 180 190 200 210 220 230 240 pF1KE0 IILPCFILPGI CCDS75 MKWLKDKQPMDAKEFEPKDVLPNGDGTYQGWITLAVPPGEEQRYTCQVEHPGLDQPLIVI 240 250 260 270 280 290 246 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Wed Nov 2 22:47:37 2016 done: Wed Nov 2 22:47:37 2016 Total Scan time: 2.200 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]