FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0592, 476 aa 1>>>pF1KE0592 476 - 476 aa - 476 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.5199+/-0.00114; mu= 16.3655+/- 0.067 mean_var=63.8005+/-13.171, 0's: 0 Z-trim(101.7): 34 B-trim: 270 in 1/46 Lambda= 0.160569 statistics sampled from 6618 (6631) to 6618 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.553), E-opt: 0.2 (0.204), width: 16 Scan time: 2.690 The best scores are: opt bits E(32554) CCDS3046.1 SEC61A1 gene_id:29927|Hs108|chr3 ( 476) 3083 723.4 1.2e-208 CCDS7088.1 SEC61A2 gene_id:55176|Hs108|chr10 ( 476) 2958 694.5 6.5e-200 CCDS44359.1 SEC61A2 gene_id:55176|Hs108|chr10 ( 454) 2655 624.3 8.4e-179 CCDS44358.1 SEC61A2 gene_id:55176|Hs108|chr10 ( 437) 2589 609.0 3.2e-174 >>CCDS3046.1 SEC61A1 gene_id:29927|Hs108|chr3 (476 aa) initn: 3083 init1: 3083 opt: 3083 Z-score: 3859.1 bits: 723.4 E(32554): 1.2e-208 Smith-Waterman score: 3083; 100.0% identity (100.0% similar) in 476 aa overlap (1-476:1-476) 10 20 30 40 50 60 pF1KE0 MAIKFLEVIKPFCVILPEIQKPERKIQFKEKVLWTAITLFIFLVCCQIPLFGIMSSDSAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 MAIKFLEVIKPFCVILPEIQKPERKIQFKEKVLWTAITLFIFLVCCQIPLFGIMSSDSAD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 PFYWMRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVGDTPKDRALFNGAQKLFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 PFYWMRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVGDTPKDRALFNGAQKLFG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 MIITIGQSIVYVMTGMYGDPSEMGAGICLLITIQLFVAGLIVLLLDELLQKGYGLGSGIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 MIITIGQSIVYVMTGMYGDPSEMGAGICLLITIQLFVAGLIVLLLDELLQKGYGLGSGIS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 LFIATNICETIVWKAFSPTTVNTGRGMEFEGAIIALFHLLATRTDKVRALREAFYRQNLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 LFIATNICETIVWKAFSPTTVNTGRGMEFEGAIIALFHLLATRTDKVRALREAFYRQNLP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 NLMNLIATIFVFAVVIYFQGFRVDLPIKSARYRGQYNTYPIKLFYTSNIPIILQSALVSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 NLMNLIATIFVFAVVIYFQGFRVDLPIKSARYRGQYNTYPIKLFYTSNIPIILQSALVSN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 LYVISQMLSARFSGNLLVSLLGTWSDTSSGGPARAYPVGGLCYYLSPPESFGSVLEDPVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 LYVISQMLSARFSGNLLVSLLGTWSDTSSGGPARAYPVGGLCYYLSPPESFGSVLEDPVH 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 AVVYIVFMLGSCAFFSKTWIEVSGSSAKDVAKQLKEQQMVMRGHRETSMVHELNRYIPTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 AVVYIVFMLGSCAFFSKTWIEVSGSSAKDVAKQLKEQQMVMRGHRETSMVHELNRYIPTA 370 380 390 400 410 420 430 440 450 460 470 pF1KE0 AAFGGLCIGALSVLADFLGAIGSGTGILLAVTIIYQYFEIFVKEQSEVGSMGALLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 AAFGGLCIGALSVLADFLGAIGSGTGILLAVTIIYQYFEIFVKEQSEVGSMGALLF 430 440 450 460 470 >>CCDS7088.1 SEC61A2 gene_id:55176|Hs108|chr10 (476 aa) initn: 2977 init1: 2951 opt: 2958 Z-score: 3702.6 bits: 694.5 E(32554): 6.5e-200 Smith-Waterman score: 2958; 93.5% identity (99.4% similar) in 476 aa overlap (1-476:1-476) 10 20 30 40 50 60 pF1KE0 MAIKFLEVIKPFCVILPEIQKPERKIQFKEKVLWTAITLFIFLVCCQIPLFGIMSSDSAD :.:::::::::::..:::::::::::::.::::::::::::::::::::::::::::::: CCDS70 MGIKFLEVIKPFCAVLPEIQKPERKIQFREKVLWTAITLFIFLVCCQIPLFGIMSSDSAD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 PFYWMRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVGDTPKDRALFNGAQKLFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS70 PFYWMRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVGDTPKDRALFNGAQKLFG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 MIITIGQSIVYVMTGMYGDPSEMGAGICLLITIQLFVAGLIVLLLDELLQKGYGLGSGIS :::::::.::::::::::::.:::::::::: :::::::::::::::::::::::::::: CCDS70 MIITIGQAIVYVMTGMYGDPAEMGAGICLLIIIQLFVAGLIVLLLDELLQKGYGLGSGIS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 LFIATNICETIVWKAFSPTTVNTGRGMEFEGAIIALFHLLATRTDKVRALREAFYRQNLP ::::::::::::::::::::.::::: :::::.::::::::::::::::::::::::::: CCDS70 LFIATNICETIVWKAFSPTTINTGRGTEFEGAVIALFHLLATRTDKVRALREAFYRQNLP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 NLMNLIATIFVFAVVIYFQGFRVDLPIKSARYRGQYNTYPIKLFYTSNIPIILQSALVSN ::::::::.:::::::::::::::::::::::::::..:::::::::::::::::::::: CCDS70 NLMNLIATVFVFAVVIYFQGFRVDLPIKSARYRGQYSSYPIKLFYTSNIPIILQSALVSN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 LYVISQMLSARFSGNLLVSLLGTWSDTSSGGPARAYPVGGLCYYLSPPESFGSVLEDPVH :::::::::.:::::.::.::: :.:.:.:::::.:::::::::::::::.:...::::: CCDS70 LYVISQMLSVRFSGNFLVNLLGQWADVSGGGPARSYPVGGLCYYLSPPESMGAIFEDPVH 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 AVVYIVFMLGSCAFFSKTWIEVSGSSAKDVAKQLKEQQMVMRGHRETSMVHELNRYIPTA .::::.:::::::::::::::::::::::::::::::::::::::.:::::::::::::: CCDS70 VVVYIIFMLGSCAFFSKTWIEVSGSSAKDVAKQLKEQQMVMRGHRDTSMVHELNRYIPTA 370 380 390 400 410 420 430 440 450 460 470 pF1KE0 AAFGGLCIGALSVLADFLGAIGSGTGILLAVTIIYQYFEIFVKEQSEVGSMGALLF :::::::::::::::::::::::::::::::::::::::::::::.:::.::::.: CCDS70 AAFGGLCIGALSVLADFLGAIGSGTGILLAVTIIYQYFEIFVKEQAEVGGMGALFF 430 440 450 460 470 >>CCDS44359.1 SEC61A2 gene_id:55176|Hs108|chr10 (454 aa) initn: 2800 init1: 2653 opt: 2655 Z-score: 3323.6 bits: 624.3 E(32554): 8.4e-179 Smith-Waterman score: 2755; 89.1% identity (94.7% similar) in 476 aa overlap (1-476:1-454) 10 20 30 40 50 60 pF1KE0 MAIKFLEVIKPFCVILPEIQKPERKIQFKEKVLWTAITLFIFLVCCQIPLFGIMSSDSAD :.:::::::::::..::::::::::: :::::::::::: CCDS44 MGIKFLEVIKPFCAVLPEIQKPERKI----------------------PLFGIMSSDSAD 10 20 30 70 80 90 100 110 120 pF1KE0 PFYWMRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVGDTPKDRALFNGAQKLFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 PFYWMRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVGDTPKDRALFNGAQKLFG 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE0 MIITIGQSIVYVMTGMYGDPSEMGAGICLLITIQLFVAGLIVLLLDELLQKGYGLGSGIS :::::::.::::::::::::.:::::::::: :::::::::::::::::::::::::::: CCDS44 MIITIGQAIVYVMTGMYGDPAEMGAGICLLIIIQLFVAGLIVLLLDELLQKGYGLGSGIS 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE0 LFIATNICETIVWKAFSPTTVNTGRGMEFEGAIIALFHLLATRTDKVRALREAFYRQNLP ::::::::::::::::::::.::::: :::::.::::::::::::::::::::::::::: CCDS44 LFIATNICETIVWKAFSPTTINTGRGTEFEGAVIALFHLLATRTDKVRALREAFYRQNLP 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE0 NLMNLIATIFVFAVVIYFQGFRVDLPIKSARYRGQYNTYPIKLFYTSNIPIILQSALVSN ::::::::.:::::::::::::::::::::::::::..:::::::::::::::::::::: CCDS44 NLMNLIATVFVFAVVIYFQGFRVDLPIKSARYRGQYSSYPIKLFYTSNIPIILQSALVSN 220 230 240 250 260 270 310 320 330 340 350 360 pF1KE0 LYVISQMLSARFSGNLLVSLLGTWSDTSSGGPARAYPVGGLCYYLSPPESFGSVLEDPVH :::::::::.:::::.::.::: :.:.:.:::::.:::::::::::::::.:...::::: CCDS44 LYVISQMLSVRFSGNFLVNLLGQWADVSGGGPARSYPVGGLCYYLSPPESMGAIFEDPVH 280 290 300 310 320 330 370 380 390 400 410 420 pF1KE0 AVVYIVFMLGSCAFFSKTWIEVSGSSAKDVAKQLKEQQMVMRGHRETSMVHELNRYIPTA .::::.:::::::::::::::::::::::::::::::::::::::.:::::::::::::: CCDS44 VVVYIIFMLGSCAFFSKTWIEVSGSSAKDVAKQLKEQQMVMRGHRDTSMVHELNRYIPTA 340 350 360 370 380 390 430 440 450 460 470 pF1KE0 AAFGGLCIGALSVLADFLGAIGSGTGILLAVTIIYQYFEIFVKEQSEVGSMGALLF :::::::::::::::::::::::::::::::::::::::::::::.:::.::::.: CCDS44 AAFGGLCIGALSVLADFLGAIGSGTGILLAVTIIYQYFEIFVKEQAEVGGMGALFF 400 410 420 430 440 450 >>CCDS44358.1 SEC61A2 gene_id:55176|Hs108|chr10 (437 aa) initn: 2589 init1: 2589 opt: 2589 Z-score: 3241.2 bits: 609.0 E(32554): 3.2e-174 Smith-Waterman score: 2589; 93.3% identity (99.3% similar) in 415 aa overlap (1-415:1-415) 10 20 30 40 50 60 pF1KE0 MAIKFLEVIKPFCVILPEIQKPERKIQFKEKVLWTAITLFIFLVCCQIPLFGIMSSDSAD :.:::::::::::..:::::::::::::.::::::::::::::::::::::::::::::: CCDS44 MGIKFLEVIKPFCAVLPEIQKPERKIQFREKVLWTAITLFIFLVCCQIPLFGIMSSDSAD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 PFYWMRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVGDTPKDRALFNGAQKLFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 PFYWMRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVGDTPKDRALFNGAQKLFG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 MIITIGQSIVYVMTGMYGDPSEMGAGICLLITIQLFVAGLIVLLLDELLQKGYGLGSGIS :::::::.::::::::::::.:::::::::: :::::::::::::::::::::::::::: CCDS44 MIITIGQAIVYVMTGMYGDPAEMGAGICLLIIIQLFVAGLIVLLLDELLQKGYGLGSGIS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 LFIATNICETIVWKAFSPTTVNTGRGMEFEGAIIALFHLLATRTDKVRALREAFYRQNLP ::::::::::::::::::::.::::: :::::.::::::::::::::::::::::::::: CCDS44 LFIATNICETIVWKAFSPTTINTGRGTEFEGAVIALFHLLATRTDKVRALREAFYRQNLP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 NLMNLIATIFVFAVVIYFQGFRVDLPIKSARYRGQYNTYPIKLFYTSNIPIILQSALVSN ::::::::.:::::::::::::::::::::::::::..:::::::::::::::::::::: CCDS44 NLMNLIATVFVFAVVIYFQGFRVDLPIKSARYRGQYSSYPIKLFYTSNIPIILQSALVSN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 LYVISQMLSARFSGNLLVSLLGTWSDTSSGGPARAYPVGGLCYYLSPPESFGSVLEDPVH :::::::::.:::::.::.::: :.:.:.:::::.:::::::::::::::.:...::::: CCDS44 LYVISQMLSVRFSGNFLVNLLGQWADVSGGGPARSYPVGGLCYYLSPPESMGAIFEDPVH 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 AVVYIVFMLGSCAFFSKTWIEVSGSSAKDVAKQLKEQQMVMRGHRETSMVHELNRYIPTA .::::.:::::::::::::::::::::::::::::::::::::::.::::::::: CCDS44 VVVYIIFMLGSCAFFSKTWIEVSGSSAKDVAKQLKEQQMVMRGHRDTSMVHELNRPKVKL 370 380 390 400 410 420 430 440 450 460 470 pF1KE0 AAFGGLCIGALSVLADFLGAIGSGTGILLAVTIIYQYFEIFVKEQSEVGSMGALLF CCDS44 RRWKGEGRHFTKRILFY 430 476 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Wed Nov 2 20:55:32 2016 done: Wed Nov 2 20:55:32 2016 Total Scan time: 2.690 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]