FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0611, 172 aa 1>>>pF1KE0611 172 - 172 aa - 172 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.9545+/-0.000505; mu= 13.2647+/- 0.032 mean_var=321.6845+/-72.875, 0's: 0 Z-trim(117.4): 303 B-trim: 1817 in 1/50 Lambda= 0.071509 statistics sampled from 29056 (29430) to 29056 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.686), E-opt: 0.2 (0.345), width: 16 Scan time: 5.510 The best scores are: opt bits E(85289) NP_001271 (OMIM: 602649) cold-inducible RNA-bindin ( 172) 1159 132.3 3.9e-31 XP_006722700 (OMIM: 602649) PREDICTED: cold-induci ( 172) 1159 132.3 3.9e-31 NP_001287758 (OMIM: 602649) cold-inducible RNA-bin ( 297) 1133 130.0 3.1e-30 NP_001287744 (OMIM: 602649) cold-inducible RNA-bin ( 168) 1126 128.8 4.1e-30 XP_016881726 (OMIM: 602649) PREDICTED: cold-induci ( 168) 1126 128.8 4.1e-30 XP_011525970 (OMIM: 602649) PREDICTED: cold-induci ( 202) 1126 129.0 4.4e-30 NP_006734 (OMIM: 300027) RNA-binding protein 3 [Ho ( 157) 526 66.9 1.7e-11 NP_002130 (OMIM: 300199,300238) RNA-binding motif ( 391) 412 55.9 8.7e-08 NP_055284 (OMIM: 605444) RNA-binding motif protein ( 392) 374 52.0 1.3e-06 XP_011529740 (OMIM: 400006,415000) PREDICTED: RNA- ( 385) 355 50.0 5.1e-06 XP_011529739 (OMIM: 400006,415000) PREDICTED: RNA- ( 422) 355 50.1 5.3e-06 NP_001307873 (OMIM: 400006,415000) RNA-binding mot ( 459) 355 50.1 5.5e-06 NP_005049 (OMIM: 400006,415000) RNA-binding motif ( 496) 355 50.2 5.7e-06 XP_011511374 (OMIM: 602719) PREDICTED: transformer ( 188) 347 48.6 6.6e-06 NP_001230808 (OMIM: 602719) transformer-2 protein ( 188) 347 48.6 6.6e-06 XP_005247760 (OMIM: 602719) PREDICTED: transformer ( 188) 347 48.6 6.6e-06 XP_016862522 (OMIM: 602719) PREDICTED: transformer ( 188) 347 48.6 6.6e-06 NP_004584 (OMIM: 602719) transformer-2 protein hom ( 288) 347 48.9 8e-06 NP_006796 (OMIM: 609409) heterogeneous nuclear rib ( 305) 344 48.7 1e-05 NP_001269688 (OMIM: 602718) transformer-2 protein ( 180) 331 46.9 2e-05 XP_005249782 (OMIM: 602718) PREDICTED: transformer ( 181) 328 46.6 2.5e-05 XP_016867578 (OMIM: 602718) PREDICTED: transformer ( 181) 328 46.6 2.5e-05 NP_001269687 (OMIM: 602718) transformer-2 protein ( 181) 328 46.6 2.5e-05 NP_001269686 (OMIM: 602718) transformer-2 protein ( 181) 328 46.6 2.5e-05 XP_016867579 (OMIM: 602718) PREDICTED: transformer ( 181) 328 46.6 2.5e-05 NP_037425 (OMIM: 602718) transformer-2 protein hom ( 282) 328 46.9 3.1e-05 NP_005372 (OMIM: 164035) nucleolin [Homo sapiens] ( 710) 325 47.4 5.6e-05 XP_016880431 (OMIM: 600813) PREDICTED: serine/argi ( 221) 291 42.9 0.00039 NP_001182356 (OMIM: 600813) serine/arginine-rich s ( 221) 291 42.9 0.00039 NP_003007 (OMIM: 600813) serine/arginine-rich spli ( 221) 291 42.9 0.00039 NP_001158275 (OMIM: 300199,300238) RNA-binding mot ( 196) 285 42.2 0.00057 NP_115285 (OMIM: 603269) serine/arginine-rich spli ( 282) 281 42.1 0.00088 XP_016872631 (OMIM: 603269) PREDICTED: serine/argi ( 282) 281 42.1 0.00088 NP_001287865 (OMIM: 605221) serine/arginine-rich s ( 172) 252 38.7 0.0057 NP_001177935 (OMIM: 605221) serine/arginine-rich s ( 173) 252 38.7 0.0057 NP_001287866 (OMIM: 605221) serine/arginine-rich s ( 217) 250 38.7 0.0073 NP_001177934 (OMIM: 605221) serine/arginine-rich s ( 261) 250 38.8 0.0079 NP_473357 (OMIM: 605221) serine/arginine-rich spli ( 262) 250 38.8 0.0079 NP_001177936 (OMIM: 605221) serine/arginine-rich s ( 182) 247 38.2 0.0083 NP_006616 (OMIM: 605221) serine/arginine-rich spli ( 183) 247 38.2 0.0084 >>NP_001271 (OMIM: 602649) cold-inducible RNA-binding pr (172 aa) initn: 1159 init1: 1159 opt: 1159 Z-score: 680.0 bits: 132.3 E(85289): 3.9e-31 Smith-Waterman score: 1159; 100.0% identity (100.0% similar) in 172 aa overlap (1-172:1-172) 10 20 30 40 50 60 pF1KE0 MASDEGKLFVGGLSFDTNEQSLEQVFSKYGQISEVVVVKDRETQRSRGFGFVTFENIDDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MASDEGKLFVGGLSFDTNEQSLEQVFSKYGQISEVVVVKDRETQRSRGFGFVTFENIDDA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 KDAMMAMNGKSVDGRQIRVDQAGKSSDNRSRGYRGGSAGGRGFFRGGRGRGRGFSRGGGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KDAMMAMNGKSVDGRQIRVDQAGKSSDNRSRGYRGGSAGGRGFFRGGRGRGRGFSRGGGD 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 RGYGGNRFESRSGGYGGSRDYYSSRSQSGGYSDRSSGGSYRDSYDSYATHNE :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RGYGGNRFESRSGGYGGSRDYYSSRSQSGGYSDRSSGGSYRDSYDSYATHNE 130 140 150 160 170 >>XP_006722700 (OMIM: 602649) PREDICTED: cold-inducible (172 aa) initn: 1159 init1: 1159 opt: 1159 Z-score: 680.0 bits: 132.3 E(85289): 3.9e-31 Smith-Waterman score: 1159; 100.0% identity (100.0% similar) in 172 aa overlap (1-172:1-172) 10 20 30 40 50 60 pF1KE0 MASDEGKLFVGGLSFDTNEQSLEQVFSKYGQISEVVVVKDRETQRSRGFGFVTFENIDDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MASDEGKLFVGGLSFDTNEQSLEQVFSKYGQISEVVVVKDRETQRSRGFGFVTFENIDDA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 KDAMMAMNGKSVDGRQIRVDQAGKSSDNRSRGYRGGSAGGRGFFRGGRGRGRGFSRGGGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KDAMMAMNGKSVDGRQIRVDQAGKSSDNRSRGYRGGSAGGRGFFRGGRGRGRGFSRGGGD 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 RGYGGNRFESRSGGYGGSRDYYSSRSQSGGYSDRSSGGSYRDSYDSYATHNE :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RGYGGNRFESRSGGYGGSRDYYSSRSQSGGYSDRSSGGSYRDSYDSYATHNE 130 140 150 160 170 >>NP_001287758 (OMIM: 602649) cold-inducible RNA-binding (297 aa) initn: 1126 init1: 1126 opt: 1133 Z-score: 663.7 bits: 130.0 E(85289): 3.1e-30 Smith-Waterman score: 1133; 97.7% identity (99.4% similar) in 173 aa overlap (1-172:1-173) 10 20 30 40 50 60 pF1KE0 MASDEGKLFVGGLSFDTNEQSLEQVFSKYGQISEVVVVKDRETQRSRGFGFVTFENIDDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MASDEGKLFVGGLSFDTNEQSLEQVFSKYGQISEVVVVKDRETQRSRGFGFVTFENIDDA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 KDAMMAMNGKSVDGRQIRVDQAGKSSDNRSRGYRGGSAGGRGFFRGGRGRGRGFSRGGGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KDAMMAMNGKSVDGRQIRVDQAGKSSDNRSRGYRGGSAGGRGFFRGGRGRGRGFSRGGGD 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 RGYGGNRFESRSGGYGGSRDYYSSRSQSGGYSDRSSGGSYRDSYDSYA-THNE :::::::::::::::::::::::::::::::::::::::::::::::. .:.: NP_001 RGYGGNRFESRSGGYGGSRDYYSSRSQSGGYSDRSSGGSYRDSYDSYGKSHSEGATLLWP 130 140 150 160 170 180 NP_001 AVGARFTLVPSPSTLGWTLRPCHCACPEEAHLSSQSHFYRRTQKPNETDQKGKGERGPAG 190 200 210 220 230 240 >>NP_001287744 (OMIM: 602649) cold-inducible RNA-binding (168 aa) initn: 1126 init1: 1126 opt: 1126 Z-score: 661.7 bits: 128.8 E(85289): 4.1e-30 Smith-Waterman score: 1126; 100.0% identity (100.0% similar) in 167 aa overlap (1-167:1-167) 10 20 30 40 50 60 pF1KE0 MASDEGKLFVGGLSFDTNEQSLEQVFSKYGQISEVVVVKDRETQRSRGFGFVTFENIDDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MASDEGKLFVGGLSFDTNEQSLEQVFSKYGQISEVVVVKDRETQRSRGFGFVTFENIDDA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 KDAMMAMNGKSVDGRQIRVDQAGKSSDNRSRGYRGGSAGGRGFFRGGRGRGRGFSRGGGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KDAMMAMNGKSVDGRQIRVDQAGKSSDNRSRGYRGGSAGGRGFFRGGRGRGRGFSRGGGD 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 RGYGGNRFESRSGGYGGSRDYYSSRSQSGGYSDRSSGGSYRDSYDSYATHNE ::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RGYGGNRFESRSGGYGGSRDYYSSRSQSGGYSDRSSGGSYRDSYDSYG 130 140 150 160 >>XP_016881726 (OMIM: 602649) PREDICTED: cold-inducible (168 aa) initn: 1126 init1: 1126 opt: 1126 Z-score: 661.7 bits: 128.8 E(85289): 4.1e-30 Smith-Waterman score: 1126; 100.0% identity (100.0% similar) in 167 aa overlap (1-167:1-167) 10 20 30 40 50 60 pF1KE0 MASDEGKLFVGGLSFDTNEQSLEQVFSKYGQISEVVVVKDRETQRSRGFGFVTFENIDDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MASDEGKLFVGGLSFDTNEQSLEQVFSKYGQISEVVVVKDRETQRSRGFGFVTFENIDDA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 KDAMMAMNGKSVDGRQIRVDQAGKSSDNRSRGYRGGSAGGRGFFRGGRGRGRGFSRGGGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KDAMMAMNGKSVDGRQIRVDQAGKSSDNRSRGYRGGSAGGRGFFRGGRGRGRGFSRGGGD 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 RGYGGNRFESRSGGYGGSRDYYSSRSQSGGYSDRSSGGSYRDSYDSYATHNE ::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RGYGGNRFESRSGGYGGSRDYYSSRSQSGGYSDRSSGGSYRDSYDSYG 130 140 150 160 >>XP_011525970 (OMIM: 602649) PREDICTED: cold-inducible (202 aa) initn: 1126 init1: 1126 opt: 1126 Z-score: 661.1 bits: 129.0 E(85289): 4.4e-30 Smith-Waterman score: 1126; 100.0% identity (100.0% similar) in 167 aa overlap (1-167:1-167) 10 20 30 40 50 60 pF1KE0 MASDEGKLFVGGLSFDTNEQSLEQVFSKYGQISEVVVVKDRETQRSRGFGFVTFENIDDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MASDEGKLFVGGLSFDTNEQSLEQVFSKYGQISEVVVVKDRETQRSRGFGFVTFENIDDA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 KDAMMAMNGKSVDGRQIRVDQAGKSSDNRSRGYRGGSAGGRGFFRGGRGRGRGFSRGGGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KDAMMAMNGKSVDGRQIRVDQAGKSSDNRSRGYRGGSAGGRGFFRGGRGRGRGFSRGGGD 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 RGYGGNRFESRSGGYGGSRDYYSSRSQSGGYSDRSSGGSYRDSYDSYATHNE ::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RGYGGNRFESRSGGYGGSRDYYSSRSQSGGYSDRSSGGSYRDSYDSYEAGQRAEARGIPG 130 140 150 160 170 180 XP_011 RPQTASRLASSAVASRVLSILC 190 200 >>NP_006734 (OMIM: 300027) RNA-binding protein 3 [Homo s (157 aa) initn: 669 init1: 466 opt: 526 Z-score: 327.4 bits: 66.9 E(85289): 1.7e-11 Smith-Waterman score: 653; 64.9% identity (83.0% similar) in 171 aa overlap (1-166:1-157) 10 20 30 40 50 60 pF1KE0 MASDEGKLFVGGLSFDTNEQSLEQVFSKYGQISEVVVVKDRETQRSRGFGFVTFENIDDA :.:.:::::::::.:.:.::.::. ::..: ::::::::::::::::::::.:: : . : NP_006 MSSEEGKLFVGGLNFNTDEQALEDHFSSFGPISEVVVVKDRETQRSRGFGFITFTNPEHA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 KDAMMAMNGKSVDGRQIRVDQAGKSSDNRSRGYRGGSAGGRGFFRGGRGRGRGFSRGGGD . :: ::::.:.::::::::.::::. :: ::: :: :..::::..:::::: NP_006 SVAMRAMNGESLDGRQIRVDHAGKSA----RGTRGG-----GF--GAHGRGRSYSRGGGD 70 80 90 100 130 140 150 160 170 pF1KE0 RGYGGNRF-ESRSGGYG-G---SRDYYSSRSQSGGYSDRSSGGSYRDSYDSYATHNE .:::..:. .:: :::: : :::: ..:.: ::: :: :::.:::.::. NP_006 QGYGSGRYYDSRPGGYGYGYGRSRDY-NGRNQ-GGY-DRYSGGNYRDNYDN 110 120 130 140 150 >>NP_002130 (OMIM: 300199,300238) RNA-binding motif prot (391 aa) initn: 451 init1: 368 opt: 412 Z-score: 260.8 bits: 55.9 E(85289): 8.7e-08 Smith-Waterman score: 412; 48.2% identity (66.5% similar) in 170 aa overlap (2-166:4-168) 10 20 30 40 50 pF1KE0 MASDEGKLFVGGLSFDTNEQSLEQVFSKYGQISEVVVVKDRETQRSRGFGFVTFENID :. ::::.:::. .:::..:: ::.:::.: ::...:::::..::::.:::::. NP_002 MVEADRPGKLFIGGLNTETNEKALEAVFGKYGRIVEVLLMKDRETNKSRGFAFVTFESPA 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE0 DAKDAMMAMNGKSVDGRQIRVDQAGKSSDNRSRGYRGGSAG--GRGFFRGGRGRGRGFSR ::::: :::::.::. :.:.:: : : : :: .:: :: :: ::: : NP_002 DAKDAARDMNGKSLDGKAIKVEQATKPS--FESGRRGPPPPPRSRGPPRGLRG-GRGGS- 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 GGGDRGYGGNRFESRSGGYGGSRDYYSSRSQ---SGGYSDRSSGGSYRDSYDSYATHNE :: :: . . .:::. . .. :::. . : ::.: . : : NP_002 -GGTRGPPSRGGHMDDGGYSMNFNMSSSRGPLPVKRGPPPRSGGPPPKRSAPSGPVRSSS 120 130 140 150 160 170 NP_002 GMGGRAPVSRGRDSYGGPPRREPLPSRRDVYLSPRDDGYSTKDSYSSRDYPSSRDTRDYA 180 190 200 210 220 230 >>NP_055284 (OMIM: 605444) RNA-binding motif protein, X- (392 aa) initn: 395 init1: 322 opt: 374 Z-score: 239.6 bits: 52.0 E(85289): 1.3e-06 Smith-Waterman score: 374; 47.0% identity (66.9% similar) in 151 aa overlap (2-146:4-144) 10 20 30 40 50 pF1KE0 MASDEGKLFVGGLSFDTNEQSLEQVFSKYGQISEVVVVKDRETQRSRGFGFVTFENID :. ::::.:::...:.:..:: :.:::.: ::...:::::..::::.:::::. NP_055 MVEADRPGKLFIGGLNLETDEKALEAEFGKYGRIVEVLLMKDRETNKSRGFAFVTFESPA 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE0 DAKDAMMAMNGKSVDGRQIRVDQAGKSS-DNRSRGYRGGSAGGRG-FFRGGRGRG----R ::: : :::::.::. :.: :: : . .. :: . :: :.:: :: : : NP_055 DAKAAARDMNGKSLDGKAIKVAQATKPAFESSRRGPPPPRSRGRPRFLRGTRGGGGGPRR 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE0 GFSRGGGDRGYGGNRFESRSGGYGGSRDYYSSRSQSGGYSDRSSGGSYRDSYDSYATHNE . :::: : .::: .. : ::. NP_055 SPSRGGPDD----------DGGYTADFDLRPSRAPMPMKRGPPPRRVGPPPKRAAPSGPA 130 140 150 160 170 NP_055 RSSGGGMRGRALAVRGRDGYSGPPRREPLPPRRDPYLGPRDEGYSSRDGYSSRDYREPRG 180 190 200 210 220 230 >>XP_011529740 (OMIM: 400006,415000) PREDICTED: RNA-bind (385 aa) initn: 299 init1: 168 opt: 355 Z-score: 229.1 bits: 50.0 E(85289): 5.1e-06 Smith-Waterman score: 355; 44.7% identity (67.6% similar) in 170 aa overlap (2-166:4-169) 10 20 30 40 50 pF1KE0 MASDEGKLFVGGLSFDTNEQSLEQVFSKYGQISEVVVVKDRETQRSRGFGFVTFENID :. ::::.:::. .:::. :. ::.:.: ::::...::: :..::::.:.:::: XP_011 MVEADHPGKLFIGGLNRETNEKMLKAVFGKHGPISEVLLIKDR-TSKSRGFAFITFENPA 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 DAKDAMMAMNGKSVDGRQIRVDQAGKSSDNRSRGYRGGSAGGRGFFRGGRGRG-RGFSRG :::.: :::::. :. :.:.:: : : .: : : :..:. .: :. :: ::: XP_011 DAKNAAKDMNGKSLHGKAIKVEQAKKPS-FQSGGRRRPPASSRNRSPSGSLRSARG-SRG 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 GGDRGY-GGNRFESRSGGYGGSRDYYSSRSQ---SGGYSDRSSGGSYRDSYDSYATHNE : ::. ... . .::: . . ::. . : :.::.: . : : XP_011 G-TRGWLPSHEGHLDDGGYTPDLKMSYSRGLIPVKRGPSSRSGGPPPKKSAPSAVARSNS 120 130 140 150 160 170 XP_011 WMGSQGPMSQRRENYGVPPRRATISSWRNDRMSTRHDGYATNDGNHPSCQETRDYAPPSR 180 190 200 210 220 230 172 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Wed Nov 2 20:25:36 2016 done: Wed Nov 2 20:25:37 2016 Total Scan time: 5.510 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]