FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0624, 370 aa 1>>>pF1KE0624 370 - 370 aa - 370 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.3495+/-0.00061; mu= -3.0815+/- 0.036 mean_var=556.4677+/-126.262, 0's: 0 Z-trim(116.4): 1901 B-trim: 488 in 1/52 Lambda= 0.054369 statistics sampled from 24884 (27498) to 24884 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.686), E-opt: 0.2 (0.322), width: 16 Scan time: 5.040 The best scores are: opt bits E(85289) NP_003647 (OMIM: 604998) calcium/calmodulin-depend ( 370) 2508 212.2 1.6e-54 XP_005265573 (OMIM: 604998) PREDICTED: calcium/cal ( 413) 2305 196.3 1e-49 XP_016862843 (OMIM: 604998) PREDICTED: calcium/cal ( 326) 2051 176.2 9.2e-44 XP_005265574 (OMIM: 604998) PREDICTED: calcium/cal ( 369) 1848 160.4 6.1e-39 XP_006717546 (OMIM: 607957) PREDICTED: calcium/cal ( 355) 1801 156.7 7.7e-38 NP_065130 (OMIM: 607957) calcium/calmodulin-depend ( 357) 1801 156.7 7.7e-38 NP_705718 (OMIM: 607957) calcium/calmodulin-depend ( 385) 1801 156.7 8e-38 XP_006717545 (OMIM: 607957) PREDICTED: calcium/cal ( 362) 1795 156.2 1.1e-37 XP_006717544 (OMIM: 607957) PREDICTED: calcium/cal ( 366) 1721 150.4 6.1e-36 XP_011517893 (OMIM: 607957) PREDICTED: calcium/cal ( 372) 1719 150.3 6.8e-36 XP_011517895 (OMIM: 607957) PREDICTED: calcium/cal ( 311) 1519 134.5 3.3e-31 XP_011517894 (OMIM: 607957) PREDICTED: calcium/cal ( 315) 1519 134.5 3.3e-31 XP_005274708 (OMIM: 300680) PREDICTED: calcium/cal ( 343) 1516 134.3 4.1e-31 XP_016884767 (OMIM: 300680) PREDICTED: calcium/cal ( 343) 1516 134.3 4.1e-31 XP_016884768 (OMIM: 300680) PREDICTED: calcium/cal ( 343) 1516 134.3 4.1e-31 XP_011529409 (OMIM: 300680) PREDICTED: calcium/cal ( 343) 1516 134.3 4.1e-31 XP_011529414 (OMIM: 300680) PREDICTED: calcium/cal ( 343) 1516 134.3 4.1e-31 XP_011529412 (OMIM: 300680) PREDICTED: calcium/cal ( 343) 1516 134.3 4.1e-31 XP_011529413 (OMIM: 300680) PREDICTED: calcium/cal ( 343) 1516 134.3 4.1e-31 XP_006724872 (OMIM: 300680) PREDICTED: calcium/cal ( 343) 1516 134.3 4.1e-31 NP_001129212 (OMIM: 300680) calcium/calmodulin-dep ( 360) 1516 134.3 4.2e-31 XP_011529410 (OMIM: 300680) PREDICTED: calcium/cal ( 361) 1516 134.3 4.2e-31 NP_001034671 (OMIM: 300680) calcium/calmodulin-dep ( 426) 1516 134.4 4.5e-31 XP_016884766 (OMIM: 300680) PREDICTED: calcium/cal ( 426) 1516 134.4 4.5e-31 XP_016857355 (OMIM: 614994) PREDICTED: calcium/cal ( 476) 1482 131.9 3e-30 NP_065172 (OMIM: 614994) calcium/calmodulin-depend ( 476) 1482 131.9 3e-30 XP_016871928 (OMIM: 607957) PREDICTED: calcium/cal ( 260) 1408 125.6 1.3e-28 XP_011517897 (OMIM: 607957) PREDICTED: calcium/cal ( 288) 1408 125.7 1.3e-28 XP_016871927 (OMIM: 607957) PREDICTED: calcium/cal ( 288) 1408 125.7 1.3e-28 XP_011517896 (OMIM: 607957) PREDICTED: calcium/cal ( 248) 1191 108.6 1.6e-23 NP_076951 (OMIM: 614993) caM kinase-like vesicle-a ( 501) 1005 94.5 5.7e-19 NP_001307076 (OMIM: 614993) caM kinase-like vesicl ( 470) 999 94.0 7.7e-19 NP_001310304 (OMIM: 114080) calcium/calmodulin-dep ( 473) 927 88.3 3.9e-17 NP_001735 (OMIM: 114080) calcium/calmodulin-depend ( 473) 927 88.3 3.9e-17 NP_001310303 (OMIM: 114080) calcium/calmodulin-dep ( 473) 927 88.3 3.9e-17 NP_006733 (OMIM: 177015) serine/threonine-protein ( 424) 925 88.1 4.1e-17 XP_016857356 (OMIM: 614994) PREDICTED: calcium/cal ( 316) 885 84.7 3.1e-16 XP_005262843 (OMIM: 613166) PREDICTED: serine/thre ( 765) 871 84.3 1e-15 NP_001035350 (OMIM: 613166) serine/threonine-prote ( 766) 871 84.3 1e-15 XP_005262842 (OMIM: 613166) PREDICTED: serine/thre ( 782) 871 84.3 1e-15 NP_001035351 (OMIM: 613166) serine/threonine-prote ( 783) 871 84.3 1e-15 XP_016863321 (OMIM: 613166) PREDICTED: serine/thre ( 717) 865 83.8 1.4e-15 NP_001182344 (OMIM: 604742) serine/threonine-prote ( 422) 850 82.2 2.4e-15 NP_001182345 (OMIM: 604742) serine/threonine-prote ( 433) 850 82.2 2.4e-15 XP_016876336 (OMIM: 604742) PREDICTED: serine/thre ( 708) 850 82.6 3.1e-15 NP_004725 (OMIM: 604742) serine/threonine-protein ( 729) 850 82.6 3.2e-15 NP_001317000 (OMIM: 604742) serine/threonine-prote ( 740) 850 82.6 3.2e-15 NP_001317001 (OMIM: 604742) serine/threonine-prote ( 740) 850 82.6 3.2e-15 XP_016884769 (OMIM: 300680) PREDICTED: calcium/cal ( 221) 783 76.5 6.6e-14 NP_751910 (OMIM: 602123) calcium/calmodulin-depend ( 518) 784 77.2 9.6e-14 >>NP_003647 (OMIM: 604998) calcium/calmodulin-dependent (370 aa) initn: 2508 init1: 2508 opt: 2508 Z-score: 1099.9 bits: 212.2 E(85289): 1.6e-54 Smith-Waterman score: 2508; 100.0% identity (100.0% similar) in 370 aa overlap (1-370:1-370) 10 20 30 40 50 60 pF1KE0 MLGAVEGPRWKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MLGAVEGPRWKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 GSMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 GSMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 LIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 TPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 TPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 YWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQSVSEQIKKNFAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 YWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQSVSEQIKKNFAK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 SKWKQAFNATAVVRHMRKLQLGTSQEGQGQTASHGELLTPVAGGPAAGCCCRDCCVEPGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 SKWKQAFNATAVVRHMRKLQLGTSQEGQGQTASHGELLTPVAGGPAAGCCCRDCCVEPGT 310 320 330 340 350 360 370 pF1KE0 ELSPTLPHQL :::::::::: NP_003 ELSPTLPHQL 370 >>XP_005265573 (OMIM: 604998) PREDICTED: calcium/calmodu (413 aa) initn: 2298 init1: 2298 opt: 2305 Z-score: 1013.4 bits: 196.3 E(85289): 1e-49 Smith-Waterman score: 2305; 94.3% identity (95.4% similar) in 371 aa overlap (1-367:1-371) 10 20 30 40 50 60 pF1KE0 MLGAVEGPRWKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MLGAVEGPRWKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 GSMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GSMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 LIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 TPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 YWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQSVSEQIKKNFAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQSVSEQIKKNFAK 250 260 270 280 290 300 310 320 330 340 350 pF1KE0 SKWKQAFNATAVVRHMRKLQLGTSQEGQGQTASHGELLTPVAGGPA----AGCCCRDCCV :::::::::::::::::::::::::::::::::::::::::::: : . :. XP_005 SKWKQAFNATAVVRHMRKLQLGTSQEGQGQTASHGELLTPVAGGEERALQKGMGGPQRCT 310 320 330 340 350 360 360 370 pF1KE0 EPGTELSPTLPHQL . :.: : : XP_005 RAGVEGLPLRPPLFCLPMQGRQLAVAVETAAWSRAQNCPPHCPTSSRALDLGS 370 380 390 400 410 >>XP_016862843 (OMIM: 604998) PREDICTED: calcium/calmodu (326 aa) initn: 2051 init1: 2051 opt: 2051 Z-score: 906.6 bits: 176.2 E(85289): 9.2e-44 Smith-Waterman score: 2141; 88.1% identity (88.1% similar) in 370 aa overlap (1-370:1-326) 10 20 30 40 50 60 pF1KE0 MLGAVEGPRWKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKE :::::::::::::::::::::::::::: XP_016 MLGAVEGPRWKQAEDIRDIYDFRDVLGT-------------------------------- 10 20 70 80 90 100 110 120 pF1KE0 GSMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASR :::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ------------IKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASR 30 40 50 60 70 130 140 150 160 170 180 pF1KE0 LIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACG 80 90 100 110 120 130 190 200 210 220 230 240 pF1KE0 TPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSP 140 150 160 170 180 190 250 260 270 280 290 300 pF1KE0 YWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQSVSEQIKKNFAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQSVSEQIKKNFAK 200 210 220 230 240 250 310 320 330 340 350 360 pF1KE0 SKWKQAFNATAVVRHMRKLQLGTSQEGQGQTASHGELLTPVAGGPAAGCCCRDCCVEPGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SKWKQAFNATAVVRHMRKLQLGTSQEGQGQTASHGELLTPVAGGPAAGCCCRDCCVEPGT 260 270 280 290 300 310 370 pF1KE0 ELSPTLPHQL :::::::::: XP_016 ELSPTLPHQL 320 >>XP_005265574 (OMIM: 604998) PREDICTED: calcium/calmodu (369 aa) initn: 1841 init1: 1841 opt: 1848 Z-score: 820.1 bits: 160.4 E(85289): 6.1e-39 Smith-Waterman score: 1938; 82.5% identity (83.6% similar) in 371 aa overlap (1-367:1-327) 10 20 30 40 50 60 pF1KE0 MLGAVEGPRWKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKE :::::::::::::::::::::::::::: XP_005 MLGAVEGPRWKQAEDIRDIYDFRDVLGT-------------------------------- 10 20 70 80 90 100 110 120 pF1KE0 GSMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASR :::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ------------IKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASR 30 40 50 60 70 130 140 150 160 170 180 pF1KE0 LIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACG 80 90 100 110 120 130 190 200 210 220 230 240 pF1KE0 TPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSP 140 150 160 170 180 190 250 260 270 280 290 300 pF1KE0 YWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQSVSEQIKKNFAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQSVSEQIKKNFAK 200 210 220 230 240 250 310 320 330 340 350 pF1KE0 SKWKQAFNATAVVRHMRKLQLGTSQEGQGQTASHGELLTPVAGGPA----AGCCCRDCCV :::::::::::::::::::::::::::::::::::::::::::: : . :. XP_005 SKWKQAFNATAVVRHMRKLQLGTSQEGQGQTASHGELLTPVAGGEERALQKGMGGPQRCT 260 270 280 290 300 310 360 370 pF1KE0 EPGTELSPTLPHQL . :.: : : XP_005 RAGVEGLPLRPPLFCLPMQGRQLAVAVETAAWSRAQNCPPHCPTSSRALDLGS 320 330 340 350 360 >>XP_006717546 (OMIM: 607957) PREDICTED: calcium/calmodu (355 aa) initn: 1847 init1: 1798 opt: 1801 Z-score: 800.3 bits: 156.7 E(85289): 7.7e-38 Smith-Waterman score: 1801; 82.2% identity (94.2% similar) in 325 aa overlap (10-333:12-336) 10 20 30 40 50 pF1KE0 MLGAVEGPRWK-QAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALE :: :::::. :..:...:::::::::.:::.: : :: :.::: :.::. XP_006 MARENGESSSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALK 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE0 GKEGSMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERD :::.:.:::::::.:::: :::::.::::: .::::.:::::::::::::::::::::.: XP_006 GKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKD 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE0 ASRLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLST :: :: :::::: ::: .:::::::::::::::: ::.:::::::::::::: :.:.:: XP_006 ASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMST 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE0 ACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEF ::::::::::::::::::::::::::::::::::::::::::::::.::::::::::::: XP_006 ACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEF 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE0 DSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQSVSEQIKKN :::::::::::::::::.::::::.::.::::: .::::::::::.::::.::: ::.:: XP_006 DSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKN 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE0 FAKSKWKQAFNATAVVRHMRKLQLGTSQEGQGQTASHGELLTPVAGGPAAGCCCRDCCVE ::::::.:::::::::::::::.::.: .... ..: XP_006 FAKSKWRQAFNATAVVRHMRKLHLGSSLDSSNASVSSSLSLASQKDCASGTFHAL 310 320 330 340 350 360 370 pF1KE0 PGTELSPTLPHQL >>NP_065130 (OMIM: 607957) calcium/calmodulin-dependent (357 aa) initn: 1847 init1: 1798 opt: 1801 Z-score: 800.3 bits: 156.7 E(85289): 7.7e-38 Smith-Waterman score: 1801; 82.2% identity (94.2% similar) in 325 aa overlap (10-333:12-336) 10 20 30 40 50 pF1KE0 MLGAVEGPRWK-QAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALE :: :::::. :..:...:::::::::.:::.: : :: :.::: :.::. NP_065 MARENGESSSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALK 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE0 GKEGSMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERD :::.:.:::::::.:::: :::::.::::: .::::.:::::::::::::::::::::.: NP_065 GKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKD 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE0 ASRLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLST :: :: :::::: ::: .:::::::::::::::: ::.:::::::::::::: :.:.:: NP_065 ASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMST 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE0 ACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEF ::::::::::::::::::::::::::::::::::::::::::::::.::::::::::::: NP_065 ACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEF 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE0 DSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQSVSEQIKKN :::::::::::::::::.::::::.::.::::: .::::::::::.::::.::: ::.:: NP_065 DSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKN 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE0 FAKSKWKQAFNATAVVRHMRKLQLGTSQEGQGQTASHGELLTPVAGGPAAGCCCRDCCVE ::::::.:::::::::::::::.::.: .... ..: NP_065 FAKSKWRQAFNATAVVRHMRKLHLGSSLDSSNASVSSSLSLASQKDCAYVAKPESLS 310 320 330 340 350 360 370 pF1KE0 PGTELSPTLPHQL >>NP_705718 (OMIM: 607957) calcium/calmodulin-dependent (385 aa) initn: 1827 init1: 1798 opt: 1801 Z-score: 800.0 bits: 156.7 E(85289): 8e-38 Smith-Waterman score: 1801; 82.2% identity (94.2% similar) in 325 aa overlap (10-333:12-336) 10 20 30 40 50 pF1KE0 MLGAVEGPRWK-QAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALE :: :::::. :..:...:::::::::.:::.: : :: :.::: :.::. NP_705 MARENGESSSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALK 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE0 GKEGSMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERD :::.:.:::::::.:::: :::::.::::: .::::.:::::::::::::::::::::.: NP_705 GKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKD 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE0 ASRLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLST :: :: :::::: ::: .:::::::::::::::: ::.:::::::::::::: :.:.:: NP_705 ASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMST 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE0 ACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEF ::::::::::::::::::::::::::::::::::::::::::::::.::::::::::::: NP_705 ACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEF 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE0 DSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQSVSEQIKKN :::::::::::::::::.::::::.::.::::: .::::::::::.::::.::: ::.:: NP_705 DSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKN 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE0 FAKSKWKQAFNATAVVRHMRKLQLGTSQEGQGQTASHGELLTPVAGGPAAGCCCRDCCVE ::::::.:::::::::::::::.::.: .... ..: NP_705 FAKSKWRQAFNATAVVRHMRKLHLGSSLDSSNASVSSSLSLASQKDCLAPSTLCSFISSS 310 320 330 340 350 360 360 370 pF1KE0 PGTELSPTLPHQL NP_705 SGVSGVGAERRPRPTTVTAVHSGSK 370 380 >>XP_006717545 (OMIM: 607957) PREDICTED: calcium/calmodu (362 aa) initn: 1821 init1: 1792 opt: 1795 Z-score: 797.7 bits: 156.2 E(85289): 1.1e-37 Smith-Waterman score: 1795; 84.2% identity (94.6% similar) in 316 aa overlap (10-324:12-327) 10 20 30 40 50 pF1KE0 MLGAVEGPRWK-QAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALE :: :::::. :..:...:::::::::.:::.: : :: :.::: :.::. XP_006 MARENGESSSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALK 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE0 GKEGSMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERD :::.:.:::::::.:::: :::::.::::: .::::.:::::::::::::::::::::.: XP_006 GKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKD 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE0 ASRLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLST :: :: :::::: ::: .:::::::::::::::: ::.:::::::::::::: :.:.:: XP_006 ASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMST 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE0 ACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEF ::::::::::::::::::::::::::::::::::::::::::::::.::::::::::::: XP_006 ACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEF 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE0 DSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQSVSEQIKKN :::::::::::::::::.::::::.::.::::: .::::::::::.::::.::: ::.:: XP_006 DSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKN 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE0 FAKSKWKQAFNATAVVRHMRKLQLGTSQEGQGQTASHGELLTPVAGGPAAGCCCRDCCVE ::::::.:::::::::::::::.::.: XP_006 FAKSKWRQAFNATAVVRHMRKLHLGSSLDSSNVWHLPRSVVSFLLRRGSQELEPSGDPGP 310 320 330 340 350 360 >>XP_006717544 (OMIM: 607957) PREDICTED: calcium/calmodu (366 aa) initn: 1746 init1: 1717 opt: 1721 Z-score: 766.3 bits: 150.4 E(85289): 6.1e-36 Smith-Waterman score: 1721; 83.1% identity (94.2% similar) in 308 aa overlap (26-333:10-317) 10 20 30 40 50 60 pF1KE0 MLGAVEGPRWKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKE : .::::::.:::.: : :: :.::: :.::.::: XP_006 MNVDLLSCALWSGAFSEVVLAEEKATGKLFAVKCIPKKALKGKE 10 20 30 40 70 80 90 100 110 120 pF1KE0 GSMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASR .:.:::::::.:::: :::::.::::: .::::.:::::::::::::::::::::.::: XP_006 SSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDAST 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE0 LIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACG :: :::::: ::: .:::::::::::::::: ::.:::::::::::::: :.:.::::: XP_006 LIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACG 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE0 TPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSP :::::::::::::::::::::::::::::::::::::::::::.:::::::::::::::: XP_006 TPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSP 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE0 YWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQSVSEQIKKNFAK ::::::::::::::.::::::.::.::::: .::::::::::.::::.::: ::.::::: XP_006 YWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKNFAK 230 240 250 260 270 280 310 320 330 340 350 360 pF1KE0 SKWKQAFNATAVVRHMRKLQLGTSQEGQGQTASHGELLTPVAGGPAAGCCCRDCCVEPGT :::.:::::::::::::::.::.: .... ..: XP_006 SKWRQAFNATAVVRHMRKLHLGSSLDSSNASVSSSLSLASQKDCLAPSTLCSFISSSSGV 290 300 310 320 330 340 370 pF1KE0 ELSPTLPHQL XP_006 SGVGAERRPRPTTVTAVHSGSK 350 360 >>XP_011517893 (OMIM: 607957) PREDICTED: calcium/calmodu (372 aa) initn: 1746 init1: 1717 opt: 1719 Z-score: 765.4 bits: 150.3 E(85289): 6.8e-36 Smith-Waterman score: 1719; 83.3% identity (94.4% similar) in 306 aa overlap (28-333:18-323) 10 20 30 40 50 60 pF1KE0 MLGAVEGPRWKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKE .::::::.:::.: : :: :.::: :.::.::: XP_011 METPPYSMEGPSCPICPSGAFSEVVLAEEKATGKLFAVKCIPKKALKGKE 10 20 30 40 50 70 80 90 100 110 120 pF1KE0 GSMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASR .:.:::::::.:::: :::::.::::: .::::.:::::::::::::::::::::.::: XP_011 SSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDAST 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE0 LIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACG :: :::::: ::: .:::::::::::::::: ::.:::::::::::::: :.:.::::: XP_011 LIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACG 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE0 TPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSP :::::::::::::::::::::::::::::::::::::::::::.:::::::::::::::: XP_011 TPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSP 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE0 YWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQSVSEQIKKNFAK ::::::::::::::.::::::.::.::::: .::::::::::.::::.::: ::.::::: XP_011 YWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKNFAK 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE0 SKWKQAFNATAVVRHMRKLQLGTSQEGQGQTASHGELLTPVAGGPAAGCCCRDCCVEPGT :::.:::::::::::::::.::.: .... ..: XP_011 SKWRQAFNATAVVRHMRKLHLGSSLDSSNASVSSSLSLASQKDCLAPSTLCSFISSSSGV 300 310 320 330 340 350 370 pF1KE0 ELSPTLPHQL XP_011 SGVGAERRPRPTTVTAVHSGSK 360 370 370 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Wed Nov 2 19:48:31 2016 done: Wed Nov 2 19:48:31 2016 Total Scan time: 5.040 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]