FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0632, 376 aa 1>>>pF1KE0632 376 - 376 aa - 376 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.6065+/-0.000761; mu= 11.9187+/- 0.046 mean_var=128.6393+/-24.546, 0's: 0 Z-trim(112.7): 60 B-trim: 7 in 1/53 Lambda= 0.113080 statistics sampled from 13404 (13460) to 13404 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.757), E-opt: 0.2 (0.413), width: 16 Scan time: 3.090 The best scores are: opt bits E(32554) CCDS12022.1 PARD6G gene_id:84552|Hs108|chr18 ( 376) 2525 422.8 2.4e-118 CCDS33485.1 PARD6B gene_id:84612|Hs108|chr20 ( 372) 1331 228.0 1e-59 CCDS10843.1 PARD6A gene_id:50855|Hs108|chr16 ( 346) 1084 187.7 1.3e-47 CCDS45514.1 PARD6A gene_id:50855|Hs108|chr16 ( 345) 1081 187.2 1.9e-47 >>CCDS12022.1 PARD6G gene_id:84552|Hs108|chr18 (376 aa) initn: 2525 init1: 2525 opt: 2525 Z-score: 2238.1 bits: 422.8 E(32554): 2.4e-118 Smith-Waterman score: 2525; 100.0% identity (100.0% similar) in 376 aa overlap (1-376:1-376) 10 20 30 40 50 60 pF1KE0 MNRSFHKSQTLRFYDCSAVEVKSKFGAEFRRFSLDRHKPGKFEDFYKLVVHTHHISNSDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 MNRSFHKSQTLRFYDCSAVEVKSKFGAEFRRFSLDRHKPGKFEDFYKLVVHTHHISNSDV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 TIGYADVHGDLLPINNDDNFCKAVSSANPLLRVFIQKREEAERGSLGAGSLCRRRRALGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 TIGYADVHGDLLPINNDDNFCKAVSSANPLLRVFIQKREEAERGSLGAGSLCRRRRALGA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 LRDEGPRRRAHLDIGLPRDFRPVSSIIDVDLVPETHRRVRLHRHGCEKPLGFYIRDGASV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 LRDEGPRRRAHLDIGLPRDFRPVSSIIDVDLVPETHRRVRLHRHGCEKPLGFYIRDGASV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 RVTPHGLEKVPGIFISRMVPGGLAESTGLLAVNDEVLEVNGIEVAGKTLDQVTDMMIANS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 RVTPHGLEKVPGIFISRMVPGGLAESTGLLAVNDEVLEVNGIEVAGKTLDQVTDMMIANS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 HNLIVTVKPANQRNNVVRGGRALGSSGPPSDGTAGFVGPPAPRVLQNFHPDEAESDEDND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 HNLIVTVKPANQRNNVVRGGRALGSSGPPSDGTAGFVGPPAPRVLQNFHPDEAESDEDND 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 VVIEGTLEPARPPQTPGAPAGSLSRVNGAGLAQRLQRDLALDGGLQRLLSSLRADPRHSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 VVIEGTLEPARPPQTPGAPAGSLSRVNGAGLAQRLQRDLALDGGLQRLLSSLRADPRHSL 310 320 330 340 350 360 370 pF1KE0 ALPPGGVEEHGPAVTL :::::::::::::::: CCDS12 ALPPGGVEEHGPAVTL 370 >>CCDS33485.1 PARD6B gene_id:84612|Hs108|chr20 (372 aa) initn: 1306 init1: 802 opt: 1331 Z-score: 1185.4 bits: 228.0 E(32554): 1e-59 Smith-Waterman score: 1331; 64.2% identity (86.4% similar) in 316 aa overlap (1-314:1-309) 10 20 30 40 50 pF1KE0 MNRSFHKSQTLRFYDC-SAVEVKSKFGAEFRRFSLDRHKPGKFEDFYKLVVHTHHISNSD :::: :. . : ...:::::::::::::::.: ::::::.:: :. :.:.: : : CCDS33 MNRS-HRHGAGS--GCLGTMEVKSKFGAEFRRFSLERSKPGKFEEFYGLLQHVHKIPNVD 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 VTIGYADVHGDLLPINNDDNFCKAVSSANPLLRVFIQKREEAERGSLGAGSLCRRRRAL- : .::::.::::::::::::. ::::.::::::.::::.:::. ...:. .: ... .: CCDS33 VLVGYADIHGDLLPINNDDNYHKAVSTANPLLRIFIQKKEEADYSAFGTDTLIKKKNVLT 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 GALRDEGPRRRAHLDIGLPRDFRPVSSIIDVDLVPETHRRVRLHRHGCEKPLGFYIRDGA ..:: .. :.. :. :..:.::::::::::::..:::::::::...: :::::::::::. CCDS33 NVLRPDNHRKKPHIVISMPQDFRPVSSIIDVDILPETHRRVRLYKYGTEKPLGFYIRDGS 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE0 SVRVTPHGLEKVPGIFISRMVPGGLAESTGLLAVNDEVLEVNGIEVAGKTLDQVTDMMIA :::::::::::::::::::.::::::.:::::::::::::::::::.::.:::::::::: CCDS33 SVRVTPHGLEKVPGIFISRLVPGGLAQSTGLLAVNDEVLEVNGIEVSGKSLDQVTDMMIA 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE0 NSHNLIVTVKPANQRNNVVRGGRALGSSGPPSDGTAGFVGPPAPRVLQNFHPDEAESDED ::.:::.::.::::::::::..:. :::: .:.. ..: : .. .:.:.. .:.:: CCDS33 NSRNLIITVRPANQRNNVVRNSRTSGSSGQSTDNS--LLGYPQ-QIEPSFEPEDEDSEED 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE0 NDVVIEGTLEPARPPQTPGAPAGSLSRVNGAGLAQRLQRDLALDGGLQRLLSSLRADPRH :..:: . : . :. CCDS33 -DIIIEDNGVPQQIPKAVPNTESLESLTQIELSFESGQNGFIPSNEVSLAAIASSSNTEF 300 310 320 330 340 350 >>CCDS10843.1 PARD6A gene_id:50855|Hs108|chr16 (346 aa) initn: 776 init1: 749 opt: 1084 Z-score: 968.1 bits: 187.7 E(32554): 1.3e-47 Smith-Waterman score: 1110; 59.6% identity (77.9% similar) in 312 aa overlap (17-323:14-307) 10 20 30 40 50 60 pF1KE0 MNRSFHKSQTLRFYDCSAVEVKSKFGAEFRRFSLDRHKPGKFEDFYKLVVHTHHISNSDV : ::::::: ::::::.: : . . :..: .:. .:.: . :: CCDS10 MARPQRTPARSPDSIVEVKSKFDAEFRRFALPRASVSGFQEFSRLLRAVHQIPGLDV 10 20 30 40 50 70 80 90 100 110 pF1KE0 TIGYADVHGDLLPINNDDNFCKAVSSANPLLRVFIQKREEAERGSLG--AGSLCRRRRAL .::.:.::::::..:::.. .:..:. : ::...::: ::. ..:. ..:: ::...: CCDS10 LLGYTDAHGDLLPLTNDDSLHRALASGPPPLRLLVQKRAEADSSGLAFASNSLQRRKKGL 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 GALRDEGP-RRRAHLDIGLPRDFRPVSSIIDVDLVPETHRRVRLHRHGCEKPLGFYIRDG :: .: : : : :.::.::: :::.:::::.::::::::::.:: ..::::::::: CCDS10 -LLRPVAPLRTRPPLLISLPQDFRQVSSVIDVDLLPETHRRVRLHKHGSDRPLGFYIRDG 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE0 ASVRVTPHGLEKVPGIFISRMVPGGLAESTGLLAVNDEVLEVNGIEVAGKTLDQVTDMMI ::::.:.:::.::::::::.: ::::::::::::.::.::::::::::::::::::::. CCDS10 MSVRVAPQGLERVPGIFISRLVRGGLAESTGLLAVSDEILEVNGIEVAGKTLDQVTDMMV 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE0 ANSHNLIVTVKPANQRNNVVRGGRALGS-SGPPSDGTAGFVGPPAPRVLQNFHPDEAESD :::::::::::::::::::::: : : .:::: : :: : .:: CCDS10 ANSHNLIVTVKPANQRNNVVRG--ASGRLTGPPSAGP----GPAEP-----------DSD 240 250 260 270 300 310 320 330 340 350 pF1KE0 EDN-DVVIEGTLEPARPPQTPGAPAGSLSRVNGAGLAQRLQRDLALDGGLQRLLSSLRAD .:. :.:::. :. . : : .: CCDS10 DDSSDLVIENRQPPSSNGLSQGPPCWDLHPGCRHPGTRSSLPSLDDQEQASSGWGSRIRG 280 290 300 310 320 330 >>CCDS45514.1 PARD6A gene_id:50855|Hs108|chr16 (345 aa) initn: 756 init1: 756 opt: 1081 Z-score: 965.4 bits: 187.2 E(32554): 1.9e-47 Smith-Waterman score: 1107; 59.5% identity (77.5% similar) in 311 aa overlap (17-323:14-306) 10 20 30 40 50 60 pF1KE0 MNRSFHKSQTLRFYDCSAVEVKSKFGAEFRRFSLDRHKPGKFEDFYKLVVHTHHISNSDV : ::::::: ::::::.: : . . :..: .:. .:.: . :: CCDS45 MARPQRTPARSPDSIVEVKSKFDAEFRRFALPRASVSGFQEFSRLLRAVHQIPGLDV 10 20 30 40 50 70 80 90 100 110 pF1KE0 TIGYADVHGDLLPINNDDNFCKAVSSANPLLRVFIQKREEAERG-SLGAGSLCRRRRALG .::.:.::::::..:::.. .:..:. : ::...:::: : .....:: ::...: CCDS45 LLGYTDAHGDLLPLTNDDSLHRALASGPPPLRLLVQKREADSSGLAFASNSLQRRKKGL- 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 ALRDEGP-RRRAHLDIGLPRDFRPVSSIIDVDLVPETHRRVRLHRHGCEKPLGFYIRDGA :: .: : : : :.::.::: :::.:::::.::::::::::.:: ..::::::::: CCDS45 LLRPVAPLRTRPPLLISLPQDFRQVSSVIDVDLLPETHRRVRLHKHGSDRPLGFYIRDGM 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE0 SVRVTPHGLEKVPGIFISRMVPGGLAESTGLLAVNDEVLEVNGIEVAGKTLDQVTDMMIA ::::.:.:::.::::::::.: ::::::::::::.::.::::::::::::::::::::.: CCDS45 SVRVAPQGLERVPGIFISRLVRGGLAESTGLLAVSDEILEVNGIEVAGKTLDQVTDMMVA 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE0 NSHNLIVTVKPANQRNNVVRGGRALGS-SGPPSDGTAGFVGPPAPRVLQNFHPDEAESDE ::::::::::::::::::::: : : .:::: : :: : .::. CCDS45 NSHNLIVTVKPANQRNNVVRG--ASGRLTGPPSAGP----GPAEP-----------DSDD 240 250 260 270 300 310 320 330 340 350 pF1KE0 DN-DVVIEGTLEPARPPQTPGAPAGSLSRVNGAGLAQRLQRDLALDGGLQRLLSSLRADP :. :.:::. :. . : : .: CCDS45 DSSDLVIENRQPPSSNGLSQGPPCWDLHPGCRHPGTRSSLPSLDDQEQASSGWGSRIRGD 280 290 300 310 320 330 376 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 17:54:01 2016 done: Sat Nov 5 17:54:02 2016 Total Scan time: 3.090 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]