Result of FASTA (omim) for
pF1KE0633
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0633, 202 aa
1>>>pF1KE0633 202 - 202 aa - 202 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.2964+/-0.000288; mu= 15.8630+/- 0.018
mean_var=102.9255+/-20.289, 0's: 0 Z-trim(120.4): 22 B-trim: 0 in 0/58
Lambda= 0.126419
statistics sampled from 35469 (35491) to 35469 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.779), E-opt: 0.2 (0.416), width: 16
Scan time: 4.950
The best scores are: opt bits E(85289)
NP_659424 (OMIM: 601080) splicing factor U2AF 26 k ( 202) 1408 266.2 2.6e-71
NP_001035515 (OMIM: 601080) splicing factor U2AF 2 ( 181) 723 141.2 9.7e-34
XP_016883957 (OMIM: 191317) PREDICTED: splicing fa ( 207) 432 88.2 1e-17
XP_011528045 (OMIM: 191317) PREDICTED: splicing fa ( 207) 429 87.6 1.5e-17
NP_001020375 (OMIM: 191317) splicing factor U2AF 3 ( 167) 369 76.6 2.5e-14
NP_001020374 (OMIM: 191317) splicing factor U2AF 3 ( 240) 369 76.8 3.2e-14
NP_006749 (OMIM: 191317) splicing factor U2AF 35 k ( 240) 369 76.8 3.2e-14
XP_005274654 (OMIM: 300028) PREDICTED: U2 small nu ( 348) 162 39.2 0.0095
XP_016885371 (OMIM: 300028) PREDICTED: U2 small nu ( 348) 162 39.2 0.0095
XP_011543892 (OMIM: 300028) PREDICTED: U2 small nu ( 348) 162 39.2 0.0095
XP_016885372 (OMIM: 300028) PREDICTED: U2 small nu ( 348) 162 39.2 0.0095
>>NP_659424 (OMIM: 601080) splicing factor U2AF 26 kDa s (202 aa)
initn: 1408 init1: 1408 opt: 1408 Z-score: 1401.3 bits: 266.2 E(85289): 2.6e-71
Smith-Waterman score: 1408; 100.0% identity (100.0% similar) in 202 aa overlap (1-202:1-202)
10 20 30 40 50 60
pF1KE0 MAEYLASIFGTEKDKVNCSFYFKIGVCRHGDRCSRLHNKPTFSQEVFTELQEKYGEIEEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_659 MAEYLASIFGTEKDKVNCSFYFKIGVCRHGDRCSRLHNKPTFSQEVFTELQEKYGEIEEM
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 NVCDNLGDHLVGNVYVKFRREEDGERAVAELSNRWFNGQAVHGNVPEVASATSCICGPFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_659 NVCDNLGDHLVGNVYVKFRREEDGERAVAELSNRWFNGQAVHGNVPEVASATSCICGPFP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 RTSRGSSMGGDPGAGHPRGSILATIPERGTIGVPLITGMAASEALAPLPFTPNRDRCSWQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_659 RTSRGSSMGGDPGAGHPRGSILATIPERGTIGVPLITGMAASEALAPLPFTPNRDRCSWQ
130 140 150 160 170 180
190 200
pF1KE0 DLSSKPPSLSCPILPRLPGSIM
::::::::::::::::::::::
NP_659 DLSSKPPSLSCPILPRLPGSIM
190 200
>>NP_001035515 (OMIM: 601080) splicing factor U2AF 26 kD (181 aa)
initn: 717 init1: 717 opt: 723 Z-score: 726.7 bits: 141.2 E(85289): 9.7e-34
Smith-Waterman score: 723; 84.3% identity (89.8% similar) in 127 aa overlap (1-125:1-127)
10 20 30 40 50 60
pF1KE0 MAEYLASIFGTEKDKVNCSFYFKIGVCRHGDRCSRLHNKPTFSQEVFTELQEKYGEIEEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAEYLASIFGTEKDKVNCSFYFKIGVCRHGDRCSRLHNKPTFSQEVFTELQEKYGEIEEM
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 NVCDNLGDHLVGNVYVKFRREEDGERAVAELSNRWFNGQAVHGNVPEVASATSCICGPFP
:::::::::::::::::::::::::::::::::::::::::::.. :.. : .
NP_001 NVCDNLGDHLVGNVYVKFRREEDGERAVAELSNRWFNGQAVHGELSPVTDFRESCCRQYE
70 80 90 100 110 120
130 140 150 160 170
pF1KE0 --RTSRGSSMGGDPGAGHPRGSILATIPERGTIGVPLITGMAASEALAPLPFTPNRDRCS
. .::
NP_001 MGECTRGGFCNFMHLRPISQNLQRQLYGRGPRRRSPPRFHTGHHPRERNHRCSPDHWHGR
130 140 150 160 170 180
>>XP_016883957 (OMIM: 191317) PREDICTED: splicing factor (207 aa)
initn: 518 init1: 312 opt: 432 Z-score: 439.2 bits: 88.2 E(85289): 1e-17
Smith-Waterman score: 432; 52.2% identity (72.1% similar) in 136 aa overlap (1-125:1-133)
10 20 30 40 50 60
pF1KE0 MAEYLASIFGTEKDKVNCSFYFKIGVCRHGDRCSRLHNKPTFSQEVFTELQEKYGEIEEM
:::::::::::::::::::::::::.:::::::::::::::::: .. .:. : . ..
XP_016 MAEYLASIFGTEKDKVNCSFYFKIGACRHGDRCSRLHNKPTFSQTIL--IQNIYRNPQNS
10 20 30 40 50
70 80 90 100 110
pF1KE0 NVCDNLGDHL-VGNV--------YVKFRREEDGERAVAELSNRWFNGQAVHGNVPEVASA
. :.: :..: . .::::::.:.:: .:.::::::: .:... :..
XP_016 AQTAD-GSHCAVSDVEMQEHYDEFFEFRREEDAEKAVIDLNNRWFNGQPIHAELSPVTDF
60 70 80 90 100 110
120 130 140 150 160
pF1KE0 TSCICGPFP--RTSRGSSMGGDPGAGHPRGSILATIPERGTIGVPLITGMAASEALAPLP
: . . .::
XP_016 REACCRQYEMGECTRGGFCNFMHLKPISRELRRELYGRRRKKHRSRSRSRERRSRSRDRG
120 130 140 150 160 170
>>XP_011528045 (OMIM: 191317) PREDICTED: splicing factor (207 aa)
initn: 516 init1: 310 opt: 429 Z-score: 436.2 bits: 87.6 E(85289): 1.5e-17
Smith-Waterman score: 429; 51.1% identity (71.9% similar) in 135 aa overlap (1-125:1-133)
10 20 30 40 50
pF1KE0 MAEYLASIFGTEKDKVNCSFYFKIGVCRHGDRCSRLHNKPTFSQ-----EVFTELQEKYG
:::::::::::::::::::::::::.:::::::::::::::::: ... . :..
XP_011 MAEYLASIFGTEKDKVNCSFYFKIGACRHGDRCSRLHNKPTFSQTIALLNIYRNPQNSSQ
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE0 EIEEMN--VCD-NLGDHLVGNVYVKFRREEDGERAVAELSNRWFNGQAVHGNVPEVASAT
. . : : .. .: . . .::::::.:.:: .:.::::::: .:... :..
XP_011 SADGLRCAVSDVEMQEHY--DEFFEFRREEDAEKAVIDLNNRWFNGQPIHAELSPVTDFR
70 80 90 100 110
120 130 140 150 160 170
pF1KE0 SCICGPFP--RTSRGSSMGGDPGAGHPRGSILATIPERGTIGVPLITGMAASEALAPLPF
: . . .::
XP_011 EACCRQYEMGECTRGGFCNFMHLKPISRELRRELYGRRRKKHRSRSRSRERRSRSRDRGR
120 130 140 150 160 170
>>NP_001020375 (OMIM: 191317) splicing factor U2AF 35 kD (167 aa)
initn: 432 init1: 356 opt: 369 Z-score: 378.2 bits: 76.6 E(85289): 2.5e-14
Smith-Waterman score: 369; 61.6% identity (81.4% similar) in 86 aa overlap (42-125:8-93)
20 30 40 50 60 70
pF1KE0 EKDKVNCSFYFKIGVCRHGDRCSRLHNKPTFSQEVFTELQEKYGEIEEMNVCDNLGDHLV
: .:::::..:::::.::::::::::::::
NP_001 MQEHYDEFFEEVFTEMEEKYGEVEEMNVCDNLGDHLV
10 20 30
80 90 100 110 120
pF1KE0 GNVYVKFRREEDGERAVAELSNRWFNGQAVHGNVPEVASATSCICGPFP--RTSRGSSMG
::::::::::::.:.:: .:.::::::: .:... :.. : . . .::
NP_001 GNVYVKFRREEDAEKAVIDLNNRWFNGQPIHAELSPVTDFREACCRQYEMGECTRGGFCN
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE0 GDPGAGHPRGSILATIPERGTIGVPLITGMAASEALAPLPFTPNRDRCSWQDLSSKPPSL
NP_001 FMHLKPISRELRRELYGRRRKKHRSRSRSRERRSRSRDRGRGGGGGGGGGGGGRERDRRR
100 110 120 130 140 150
>>NP_001020374 (OMIM: 191317) splicing factor U2AF 35 kD (240 aa)
initn: 730 init1: 356 opt: 369 Z-score: 376.3 bits: 76.8 E(85289): 3.2e-14
Smith-Waterman score: 540; 55.3% identity (66.0% similar) in 159 aa overlap (8-125:8-166)
10 20 30 40
pF1KE0 MAEYLASIFGTEKDKVNCSFYFKIGVCRHGDRCSRLHNKPTFSQ----------------
::::::::::::::::::.::::::::::::::::::
NP_001 MAEYLASIFGTEKDKVNCSFYFKIGACRHGDRCSRLHNKPTFSQTILIQNIYRNPQNSAQ
10 20 30 40 50 60
50 60 70 80
pF1KE0 -----------------------EVFTELQEKYGEIEEMNVCDNLGDHLVGNVYVKFRRE
:::::..:::::.::::::::::::::::::::::::
NP_001 TADGSHCAVSDVEMQEHYDEFFEEVFTEMEEKYGEVEEMNVCDNLGDHLVGNVYVKFRRE
70 80 90 100 110 120
90 100 110 120 130
pF1KE0 EDGERAVAELSNRWFNGQAVHGNVPEVASATSCICGPFP--RTSRGSSMGGDPGAGHPRG
::.:.:: .:.::::::: .:... :.. : . . .::
NP_001 EDAEKAVIDLNNRWFNGQPIHAELSPVTDFREACCRQYEMGECTRGGFCNFMHLKPISRE
130 140 150 160 170 180
140 150 160 170 180 190
pF1KE0 SILATIPERGTIGVPLITGMAASEALAPLPFTPNRDRCSWQDLSSKPPSLSCPILPRLPG
NP_001 LRRELYGRRRKKHRSRSRSRERRSRSRDRGRGGGGGGGGGGGGRERDRRRSRDRERSGRF
190 200 210 220 230 240
>>NP_006749 (OMIM: 191317) splicing factor U2AF 35 kDa s (240 aa)
initn: 728 init1: 356 opt: 369 Z-score: 376.3 bits: 76.8 E(85289): 3.2e-14
Smith-Waterman score: 540; 55.3% identity (66.0% similar) in 159 aa overlap (8-125:8-166)
10 20 30 40
pF1KE0 MAEYLASIFGTEKDKVNCSFYFKIGVCRHGDRCSRLHNKPTFSQ----------------
::::::::::::::::::.::::::::::::::::::
NP_006 MAEYLASIFGTEKDKVNCSFYFKIGACRHGDRCSRLHNKPTFSQTIALLNIYRNPQNSSQ
10 20 30 40 50 60
50 60 70 80
pF1KE0 -----------------------EVFTELQEKYGEIEEMNVCDNLGDHLVGNVYVKFRRE
:::::..:::::.::::::::::::::::::::::::
NP_006 SADGLRCAVSDVEMQEHYDEFFEEVFTEMEEKYGEVEEMNVCDNLGDHLVGNVYVKFRRE
70 80 90 100 110 120
90 100 110 120 130
pF1KE0 EDGERAVAELSNRWFNGQAVHGNVPEVASATSCICGPFP--RTSRGSSMGGDPGAGHPRG
::.:.:: .:.::::::: .:... :.. : . . .::
NP_006 EDAEKAVIDLNNRWFNGQPIHAELSPVTDFREACCRQYEMGECTRGGFCNFMHLKPISRE
130 140 150 160 170 180
140 150 160 170 180 190
pF1KE0 SILATIPERGTIGVPLITGMAASEALAPLPFTPNRDRCSWQDLSSKPPSLSCPILPRLPG
NP_006 LRRELYGRRRKKHRSRSRSRERRSRSRDRGRGGGGGGGGGGGGRERDRRRSRDRERSGRF
190 200 210 220 230 240
>>XP_005274654 (OMIM: 300028) PREDICTED: U2 small nuclea (348 aa)
initn: 277 init1: 162 opt: 162 Z-score: 170.3 bits: 39.2 E(85289): 0.0095
Smith-Waterman score: 218; 32.0% identity (50.7% similar) in 150 aa overlap (12-119:28-177)
10 20 30 40
pF1KE0 MAEYLASIFGTEKDKVNCSFYFKIGVCRHGDRCSRLHNKPTFS-
:::..:: :: : :.:: :::::: :: :: :
XP_005 MLDQAENELENGTTWQNPEPPVDFRVMEKDRANCPFYSKTGACRFGDRCSRKHNFPTSSP
10 20 30 40 50 60
50 60
pF1KE0 ----QEVFTEL--------------------QEKY-----------------GEIEEMNV
. .:: . .: : :.. ...:
XP_005 TLLIKSMFTTFGMEQCRRDDYDPDASLEYSEEETYQQFLDFYEDVLPEFKNVGKVIQFKV
70 80 90 100 110 120
70 80 90 100 110 120
pF1KE0 CDNLGDHLVGNVYVKFRREEDGERAVAELSNRWFNGQAVHGNVPEVASATSCICGPFPRT
:: :: :::::... ::. . :.. ...::. :. .. . :. ::: :
XP_005 SCNLEPHLRGNVYVQYQSEEECQAALSLFNGRWYAGRQLQCEFCPVTRWKMAICGLFEIQ
130 140 150 160 170 180
130 140 150 160 170 180
pF1KE0 SRGSSMGGDPGAGHPRGSILATIPERGTIGVPLITGMAASEALAPLPFTPNRDRCSWQDL
XP_005 QCPRGKHCNFLHVFRNPNNEFWEANRDIYLSPDRTGSSFGKNSERRERMGHHDDYYSRLR
190 200 210 220 230 240
>>XP_016885371 (OMIM: 300028) PREDICTED: U2 small nuclea (348 aa)
initn: 277 init1: 162 opt: 162 Z-score: 170.3 bits: 39.2 E(85289): 0.0095
Smith-Waterman score: 218; 32.0% identity (50.7% similar) in 150 aa overlap (12-119:28-177)
10 20 30 40
pF1KE0 MAEYLASIFGTEKDKVNCSFYFKIGVCRHGDRCSRLHNKPTFS-
:::..:: :: : :.:: :::::: :: :: :
XP_016 MLDQAENELENGTTWQNPEPPVDFRVMEKDRANCPFYSKTGACRFGDRCSRKHNFPTSSP
10 20 30 40 50 60
50 60
pF1KE0 ----QEVFTEL--------------------QEKY-----------------GEIEEMNV
. .:: . .: : :.. ...:
XP_016 TLLIKSMFTTFGMEQCRRDDYDPDASLEYSEEETYQQFLDFYEDVLPEFKNVGKVIQFKV
70 80 90 100 110 120
70 80 90 100 110 120
pF1KE0 CDNLGDHLVGNVYVKFRREEDGERAVAELSNRWFNGQAVHGNVPEVASATSCICGPFPRT
:: :: :::::... ::. . :.. ...::. :. .. . :. ::: :
XP_016 SCNLEPHLRGNVYVQYQSEEECQAALSLFNGRWYAGRQLQCEFCPVTRWKMAICGLFEIQ
130 140 150 160 170 180
130 140 150 160 170 180
pF1KE0 SRGSSMGGDPGAGHPRGSILATIPERGTIGVPLITGMAASEALAPLPFTPNRDRCSWQDL
XP_016 QCPRGKHCNFLHVFRNPNNEFWEANRDIYLSPDRTGSSFGKNSERRERMGHHDDYYSRLR
190 200 210 220 230 240
>>XP_011543892 (OMIM: 300028) PREDICTED: U2 small nuclea (348 aa)
initn: 277 init1: 162 opt: 162 Z-score: 170.3 bits: 39.2 E(85289): 0.0095
Smith-Waterman score: 218; 32.0% identity (50.7% similar) in 150 aa overlap (12-119:28-177)
10 20 30 40
pF1KE0 MAEYLASIFGTEKDKVNCSFYFKIGVCRHGDRCSRLHNKPTFS-
:::..:: :: : :.:: :::::: :: :: :
XP_011 MLDQAENELENGTTWQNPEPPVDFRVMEKDRANCPFYSKTGACRFGDRCSRKHNFPTSSP
10 20 30 40 50 60
50 60
pF1KE0 ----QEVFTEL--------------------QEKY-----------------GEIEEMNV
. .:: . .: : :.. ...:
XP_011 TLLIKSMFTTFGMEQCRRDDYDPDASLEYSEEETYQQFLDFYEDVLPEFKNVGKVIQFKV
70 80 90 100 110 120
70 80 90 100 110 120
pF1KE0 CDNLGDHLVGNVYVKFRREEDGERAVAELSNRWFNGQAVHGNVPEVASATSCICGPFPRT
:: :: :::::... ::. . :.. ...::. :. .. . :. ::: :
XP_011 SCNLEPHLRGNVYVQYQSEEECQAALSLFNGRWYAGRQLQCEFCPVTRWKMAICGLFEIQ
130 140 150 160 170 180
130 140 150 160 170 180
pF1KE0 SRGSSMGGDPGAGHPRGSILATIPERGTIGVPLITGMAASEALAPLPFTPNRDRCSWQDL
XP_011 QCPRGKHCNFLHVFRNPNNEFWEANRDIYLSPDRTGSSFGKNSERRERMGHHDDYYSRLR
190 200 210 220 230 240
202 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Wed Nov 2 19:28:24 2016 done: Wed Nov 2 19:28:25 2016
Total Scan time: 4.950 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]