FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0638, 447 aa 1>>>pF1KE0638 447 - 447 aa - 447 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.8289+/-0.000302; mu= 22.4388+/- 0.019 mean_var=96.5483+/-21.914, 0's: 0 Z-trim(119.4): 632 B-trim: 2993 in 2/53 Lambda= 0.130527 statistics sampled from 32715 (33490) to 32715 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.724), E-opt: 0.2 (0.393), width: 16 Scan time: 10.650 The best scores are: opt bits E(85289) NP_795344 (OMIM: 118445) gastrin/cholecystokinin t ( 447) 2993 573.6 3.6e-163 XP_016874005 (OMIM: 118445) PREDICTED: gastrin/cho ( 381) 2560 492.0 1.1e-138 NP_001304958 (OMIM: 118445) gastrin/cholecystokini ( 363) 2138 412.5 9.2e-115 XP_005253267 (OMIM: 118445) PREDICTED: gastrin/cho ( 516) 1760 341.5 3.1e-93 NP_000721 (OMIM: 118444) cholecystokinin receptor ( 428) 1243 244.1 5.5e-64 XP_005263095 (OMIM: 602001) PREDICTED: neuropeptid ( 445) 398 85.0 4.5e-16 NP_006165 (OMIM: 602001) neuropeptide Y receptor t ( 445) 398 85.0 4.5e-16 NP_001304020 (OMIM: 602001) neuropeptide Y recepto ( 445) 398 85.0 4.5e-16 XP_011530319 (OMIM: 602001) PREDICTED: neuropeptid ( 445) 398 85.0 4.5e-16 NP_001304021 (OMIM: 602001) neuropeptide Y recepto ( 445) 398 85.0 4.5e-16 XP_016863744 (OMIM: 602001) PREDICTED: neuropeptid ( 452) 398 85.0 4.6e-16 XP_016863745 (OMIM: 602001) PREDICTED: neuropeptid ( 452) 398 85.0 4.6e-16 XP_011530317 (OMIM: 602001) PREDICTED: neuropeptid ( 452) 398 85.0 4.6e-16 NP_001517 (OMIM: 602393) orexin receptor type 2 [H ( 444) 397 84.8 5.1e-16 XP_016866287 (OMIM: 602393) PREDICTED: orexin rece ( 461) 397 84.8 5.3e-16 XP_011530312 (OMIM: 162641) PREDICTED: neuropeptid ( 384) 369 79.4 1.8e-14 NP_000900 (OMIM: 162641) neuropeptide Y receptor t ( 384) 369 79.4 1.8e-14 XP_005263088 (OMIM: 162641) PREDICTED: neuropeptid ( 384) 369 79.4 1.8e-14 NP_000901 (OMIM: 162642) neuropeptide Y receptor t ( 381) 368 79.2 2.1e-14 XP_005263090 (OMIM: 162642) PREDICTED: neuropeptid ( 381) 368 79.2 2.1e-14 XP_005263091 (OMIM: 162642) PREDICTED: neuropeptid ( 381) 368 79.2 2.1e-14 XP_016856596 (OMIM: 602392) PREDICTED: orexin rece ( 389) 368 79.2 2.1e-14 XP_016856594 (OMIM: 602392) PREDICTED: orexin rece ( 425) 368 79.3 2.2e-14 XP_016856595 (OMIM: 602392) PREDICTED: orexin rece ( 425) 368 79.3 2.2e-14 NP_001516 (OMIM: 602392) orexin receptor type 1 [H ( 425) 368 79.3 2.2e-14 NP_000674 (OMIM: 104250) alpha-2C adrenergic recep ( 462) 365 78.8 3.4e-14 NP_003605 (OMIM: 603692) galanin receptor type 3 [ ( 368) 358 77.3 7.4e-14 NP_937822 (OMIM: 606925) pyroglutamylated RFamide ( 431) 357 77.2 9.3e-14 NP_004239 (OMIM: 600895) prolactin-releasing pepti ( 370) 356 77.0 9.6e-14 NP_000902 (OMIM: 165195) delta-type opioid recepto ( 372) 350 75.8 2.1e-13 NP_001186948 (OMIM: 602548) nociceptin receptor is ( 370) 342 74.3 6e-13 NP_000904 (OMIM: 602548) nociceptin receptor isofo ( 370) 342 74.3 6e-13 XP_016883343 (OMIM: 602548) PREDICTED: nociceptin ( 370) 342 74.3 6e-13 NP_872588 (OMIM: 602548) nociceptin receptor isofo ( 370) 342 74.3 6e-13 XP_016883341 (OMIM: 602548) PREDICTED: nociceptin ( 388) 342 74.3 6.2e-13 XP_011527130 (OMIM: 602548) PREDICTED: nociceptin ( 388) 342 74.3 6.2e-13 XP_016883342 (OMIM: 602548) PREDICTED: nociceptin ( 388) 342 74.3 6.2e-13 NP_001305782 (OMIM: 602548) nociceptin receptor is ( 399) 342 74.4 6.3e-13 NP_003848 (OMIM: 603691) galanin receptor type 2 [ ( 387) 339 73.8 9.1e-13 NP_071429 (OMIM: 607448) neuropeptide FF receptor ( 430) 337 73.5 1.3e-12 XP_016881180 (OMIM: 600377) PREDICTED: galanin rec ( 269) 334 72.6 1.4e-12 XP_011515565 (OMIM: 188545) PREDICTED: thyrotropin ( 398) 335 73.0 1.6e-12 NP_003292 (OMIM: 188545) thyrotropin-releasing hor ( 398) 335 73.0 1.6e-12 NP_001043 (OMIM: 182454) somatostatin receptor typ ( 388) 334 72.8 1.8e-12 XP_016883344 (OMIM: 602548) PREDICTED: nociceptin ( 365) 332 72.4 2.2e-12 NP_001305783 (OMIM: 602548) nociceptin receptor is ( 365) 332 72.4 2.2e-12 NP_444264 (OMIM: 607449) neuropeptide FF receptor ( 420) 332 72.5 2.4e-12 NP_001138228 (OMIM: 607449) neuropeptide FF recept ( 423) 332 72.5 2.4e-12 NP_001138757 (OMIM: 600018) mu-type opioid recepto ( 389) 331 72.3 2.6e-12 NP_001008504 (OMIM: 600018) mu-type opioid recepto ( 392) 331 72.3 2.6e-12 >>NP_795344 (OMIM: 118445) gastrin/cholecystokinin type (447 aa) initn: 2993 init1: 2993 opt: 2993 Z-score: 3050.5 bits: 573.6 E(85289): 3.6e-163 Smith-Waterman score: 2993; 100.0% identity (100.0% similar) in 447 aa overlap (1-447:1-447) 10 20 30 40 50 60 pF1KE0 MELLKLNRSVQGTGPGPGASLCRPGAPLLNSSSVGNLSCEPPRIRGAGTRELELAIRITL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_795 MELLKLNRSVQGTGPGPGASLCRPGAPLLNSSSVGNLSCEPPRIRGAGTRELELAIRITL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 YAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_795 YAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 IFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_795 IFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 LSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_795 LSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 ISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVGEDSDGCYVQLPRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_795 ISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVGEDSDGCYVQLPRS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 RPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_795 RPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 PGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_795 PGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRAL 370 380 390 400 410 420 430 440 pF1KE0 PDEDPPTPSIASLSRLSYTTISTLGPG ::::::::::::::::::::::::::: NP_795 PDEDPPTPSIASLSRLSYTTISTLGPG 430 440 >>XP_016874005 (OMIM: 118445) PREDICTED: gastrin/cholecy (381 aa) initn: 2560 init1: 2560 opt: 2560 Z-score: 2610.6 bits: 492.0 E(85289): 1.1e-138 Smith-Waterman score: 2560; 100.0% identity (100.0% similar) in 381 aa overlap (67-447:1-381) 40 50 60 70 80 90 pF1KE0 LSCEPPRIRGAGTRELELAIRITLYAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSL :::::::::::::::::::::::::::::: XP_016 MSVGGNMLIIVVLGLSRRLRTVTNAFLLSL 10 20 30 100 110 120 130 140 150 pF1KE0 AVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAI 40 50 60 70 80 90 160 170 180 190 200 210 pF1KE0 CRPLQARVWQTRSHAARVIVATWLLSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CRPLQARVWQTRSHAARVIVATWLLSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQ 100 110 120 130 140 150 220 230 240 250 260 270 pF1KE0 TWSVLLLLLLFFIPGVVMAVAYGLISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TWSVLLLLLLFFIPGVVMAVAYGLISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQN 160 170 180 190 200 210 280 290 300 310 320 330 pF1KE0 GRCRPETGAVGEDSDGCYVQLPRSRPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GRCRPETGAVGEDSDGCYVQLPRSRPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLL 220 230 240 250 260 270 340 350 360 370 380 390 pF1KE0 VIVVLFFLCWLPVYSANTWRAFDGPGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VIVVLFFLCWLPVYSANTWRAFDGPGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRR 280 290 300 310 320 330 400 410 420 430 440 pF1KE0 FRQACLETCARCCPRPPRARPRALPDEDPPTPSIASLSRLSYTTISTLGPG ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FRQACLETCARCCPRPPRARPRALPDEDPPTPSIASLSRLSYTTISTLGPG 340 350 360 370 380 >>NP_001304958 (OMIM: 118445) gastrin/cholecystokinin ty (363 aa) initn: 2138 init1: 2138 opt: 2138 Z-score: 2181.4 bits: 412.5 E(85289): 9.2e-115 Smith-Waterman score: 2303; 81.2% identity (81.2% similar) in 447 aa overlap (1-447:1-363) 10 20 30 40 50 60 pF1KE0 MELLKLNRSVQGTGPGPGASLCRPGAPLLNSSSVGNLSCEPPRIRGAGTRELELAIRITL :::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MELLKLNRSVQGTGPGPGASLCRPGAPLLNSSSVGNLSCEPPRIRGAGTR---------- 10 20 30 40 50 70 80 90 100 110 120 pF1KE0 YAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTF NP_001 ------------------------------------------------------------ 130 140 150 160 170 180 pF1KE0 IFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWL :::::::::::::::::::::::::::::::::::::::::::::: NP_001 --------------GVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWL 60 70 80 90 190 200 210 220 230 240 pF1KE0 LSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGL 100 110 120 130 140 150 250 260 270 280 290 300 pF1KE0 ISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVGEDSDGCYVQLPRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVGEDSDGCYVQLPRS 160 170 180 190 200 210 310 320 330 340 350 360 pF1KE0 RPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDG 220 230 240 250 260 270 370 380 390 400 410 420 pF1KE0 PGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRAL 280 290 300 310 320 330 430 440 pF1KE0 PDEDPPTPSIASLSRLSYTTISTLGPG ::::::::::::::::::::::::::: NP_001 PDEDPPTPSIASLSRLSYTTISTLGPG 340 350 360 >>XP_005253267 (OMIM: 118445) PREDICTED: gastrin/cholecy (516 aa) initn: 1760 init1: 1760 opt: 1760 Z-score: 1794.9 bits: 341.5 E(85289): 3.1e-93 Smith-Waterman score: 2594; 85.6% identity (85.6% similar) in 479 aa overlap (1-410:1-479) 10 20 30 40 50 60 pF1KE0 MELLKLNRSVQGTGPGPGASLCRPGAPLLNSSSVGNLSCEPPRIRGAGTRELELAIRITL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MELLKLNRSVQGTGPGPGASLCRPGAPLLNSSSVGNLSCEPPRIRGAGTRELELAIRITL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 YAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 IFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 LSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGL 190 200 210 220 230 240 250 260 270 pF1KE0 ISRELYLGLRFDGDSDSDSQSRVRNQGGLPG----------------------------- ::::::::::::::::::::::::::::::: XP_005 ISRELYLGLRFDGDSDSDSQSRVRNQGGLPGGAGPREQNLGEAELWRATGPAGVGGTEMK 250 260 270 280 290 300 280 290 pF1KE0 ----------------------------------------AVHQNGRCRPETGAVGEDSD :::::::::::::::::::: XP_005 VRVRRKLEMELSWERRSGGDWAGDWGDSPFSLTAHPLCSGAVHQNGRCRPETGAVGEDSD 310 320 330 340 350 360 300 310 320 330 340 350 pF1KE0 GCYVQLPRSRPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GCYVQLPRSRPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYS 370 380 390 400 410 420 360 370 380 390 400 410 pF1KE0 ANTWRAFDGPGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPR ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ANTWRAFDGPGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPR 430 440 450 460 470 480 420 430 440 pF1KE0 PPRARPRALPDEDPPTPSIASLSRLSYTTISTLGPG XP_005 PPRARPRALPDEDPPTPSIASLSRLSYTTISTLGPG 490 500 510 >-- initn: 251 init1: 251 opt: 251 Z-score: 259.2 bits: 57.4 E(85289): 1.1e-07 Smith-Waterman score: 251; 100.0% identity (100.0% similar) in 37 aa overlap (411-447:480-516) 390 400 410 420 430 440 pF1KE0 ASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRALPDEDPPTPSIASLSRLSYTT :::::::::::::::::::::::::::::: XP_005 ASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRALPDEDPPTPSIASLSRLSYTT 450 460 470 480 490 500 pF1KE0 ISTLGPG ::::::: XP_005 ISTLGPG 510 >>NP_000721 (OMIM: 118444) cholecystokinin receptor type (428 aa) initn: 1294 init1: 603 opt: 1243 Z-score: 1269.7 bits: 244.1 E(85289): 5.5e-64 Smith-Waterman score: 1313; 50.4% identity (73.8% similar) in 423 aa overlap (37-446:27-426) 10 20 30 40 50 60 pF1KE0 NRSVQGTGPGPGASLCRPGAPLLNSSSVGNLSC-EPPRIRGAGTRELELAIRITLYAVIF : : . :: ..: . :..: ::..:: NP_000 MDVVDSLLVNGSNITPPCELGLENETLFCLDQPR----PSKEWQPAVQILLYSLIF 10 20 30 40 50 70 80 90 100 110 120 pF1KE0 LMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTV :.:: :: :.:.:: ..:.::::: ::::::::::.: . ::::.:.:::. ::::.. NP_000 LLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSA 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE0 ICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWLLSGLL .::...:.::.::::::..::::.::::.:::.:::.:::::.::: .::.::: :: . NP_000 VCKTTTYFMGTSVSVSTFNLVAISLERYGAICKPLQSRVWQTKSHALKVIAATWCLSFTI 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE0 MVPYPVYTVVQPVGPRVLQ----CVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGLI :.:::.:. . : : : :. ..:.: ..:::.::.:::.:: :::::: NP_000 MTPYPIYSNLVPFTKNNNQTANMCRFLLPNDVMQQSWHTFLLLILFLIPGIVMMVAYGLI 180 190 200 210 220 230 250 260 270 280 290 pF1KE0 SRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVG--EDSDGCYVQLPR : ::: :..:.... .... : .: : . : :::::::.: : NP_000 SLELYQGIKFEASQKKSAKER-----------------KPSTTSSGKYEDSDGCYLQKTR 240 250 260 270 300 310 320 330 340 350 pF1KE0 SRPALELTALTAPGPGSGSR----PTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTW ::: :.. . . ..: . :.:.:::::.:::.::::::::::.:..:::.: NP_000 PPRKLELRQLSTGSSSRANRIRSNSSAANLMAKKRVIRMLIVIVVLFFLCWMPIFSANAW 280 290 300 310 320 330 360 370 380 390 400 410 pF1KE0 RAFDGPGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRP--P ::.: .:.: :::.::::: ::::.:.::::..::::..::: . . : ::: : : NP_000 RAYDTASAERRLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFP-CCPNPGPP 340 350 360 370 380 390 420 430 440 pF1KE0 RARPRALPDEDPPTPSIASLSRLSYTTISTLGPG :: .. .:. : . :::::.::. .:. : NP_000 GARGEVGEEEEGGTTG-ASLSRFSYSHMSASVPPQ 400 410 420 >>XP_005263095 (OMIM: 602001) PREDICTED: neuropeptide Y (445 aa) initn: 430 init1: 252 opt: 398 Z-score: 409.5 bits: 85.0 E(85289): 4.5e-16 Smith-Waterman score: 407; 25.6% identity (55.6% similar) in 410 aa overlap (58-408:45-442) 30 40 50 60 70 80 pF1KE0 LLNSSSVGNLSCEPPRIRGAGTRELELAIRITLYAVIFLMSVGGNMLIIVVLGLSRRLRT : ::. . :.. ::.::...: .: .: XP_005 TENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKT 20 30 40 50 60 70 90 100 110 120 130 140 pF1KE0 VTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVA ..: .. .:: ::.:... : :::: :. ..:: :.:. . .:. ::: :::: :.. XP_005 TVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILIS 80 90 100 110 120 130 150 160 170 180 190 200 pF1KE0 IALERYSAICRPLQARVWQTRSHAARVIVATWLLSGLLMVPYPVY-TVVQ---PVGPRVL ::. :: : .:.. . : .:. .:...: :. . : ::. ..:. : .: XP_005 IAIVRYHMIKHPISNNL--TANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALL 140 150 160 170 180 190 210 220 230 240 250 pF1KE0 Q----CVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGLISRELYLGLRFDGDSDSDS . ::. ::: : .... :::. ...: : ..:.. . : . :: :.. XP_005 SSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGL-------SNK 200 210 220 230 240 260 270 280 290 300 pF1KE0 QSRVRNQGGLPGAVHQNGRCRPETGAVGEDS----------------DGCYVQLPRSRPA ..:.... . ..: . . :.. : . .: . :. ::. XP_005 ENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPE-RPS 250 260 270 280 290 300 310 320 330 pF1KE0 LE----------------LTALTAPGPGSGS----RPTQA----KLLAKKRVVRM----- : :.. . :: . .: . .: .:. :.:. XP_005 QENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSR 310 320 330 340 350 360 340 350 360 370 380 pF1KE0 -----LLVIVVLFFLCWLPVYSANTWRAF-DGPGAHRALSGAPISFIHLLSYASACVNPL : .....: . :.:.. .. : :. ..: .. . . :::.. : :.::. XP_005 SVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLV-YCICHLLGMMSCCLNPI 370 380 390 400 410 420 390 400 410 420 430 440 pF1KE0 VYCFMHRRFRQACLETCARCCPRPPRARPRALPDEDPPTPSIASLSRLSYTTISTLGPG .: :.. .. : : . .: XP_005 LYGFLNNGIK-ADLVSLIHCLHM 430 440 >>NP_006165 (OMIM: 602001) neuropeptide Y receptor type (445 aa) initn: 430 init1: 252 opt: 398 Z-score: 409.5 bits: 85.0 E(85289): 4.5e-16 Smith-Waterman score: 407; 25.6% identity (55.6% similar) in 410 aa overlap (58-408:45-442) 30 40 50 60 70 80 pF1KE0 LLNSSSVGNLSCEPPRIRGAGTRELELAIRITLYAVIFLMSVGGNMLIIVVLGLSRRLRT : ::. . :.. ::.::...: .: .: NP_006 TENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKT 20 30 40 50 60 70 90 100 110 120 130 140 pF1KE0 VTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVA ..: .. .:: ::.:... : :::: :. ..:: :.:. . .:. ::: :::: :.. NP_006 TVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILIS 80 90 100 110 120 130 150 160 170 180 190 200 pF1KE0 IALERYSAICRPLQARVWQTRSHAARVIVATWLLSGLLMVPYPVY-TVVQ---PVGPRVL ::. :: : .:.. . : .:. .:...: :. . : ::. ..:. : .: NP_006 IAIVRYHMIKHPISNNL--TANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALL 140 150 160 170 180 190 210 220 230 240 250 pF1KE0 Q----CVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGLISRELYLGLRFDGDSDSDS . ::. ::: : .... :::. ...: : ..:.. . : . :: :.. NP_006 SSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGL-------SNK 200 210 220 230 240 260 270 280 290 300 pF1KE0 QSRVRNQGGLPGAVHQNGRCRPETGAVGEDS----------------DGCYVQLPRSRPA ..:.... . ..: . . :.. : . .: . :. ::. NP_006 ENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPE-RPS 250 260 270 280 290 300 310 320 330 pF1KE0 LE----------------LTALTAPGPGSGS----RPTQA----KLLAKKRVVRM----- : :.. . :: . .: . .: .:. :.:. NP_006 QENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSR 310 320 330 340 350 360 340 350 360 370 380 pF1KE0 -----LLVIVVLFFLCWLPVYSANTWRAF-DGPGAHRALSGAPISFIHLLSYASACVNPL : .....: . :.:.. .. : :. ..: .. . . :::.. : :.::. NP_006 SVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLV-YCICHLLGMMSCCLNPI 370 380 390 400 410 420 390 400 410 420 430 440 pF1KE0 VYCFMHRRFRQACLETCARCCPRPPRARPRALPDEDPPTPSIASLSRLSYTTISTLGPG .: :.. .. : : . .: NP_006 LYGFLNNGIK-ADLVSLIHCLHM 430 440 >>NP_001304020 (OMIM: 602001) neuropeptide Y receptor ty (445 aa) initn: 430 init1: 252 opt: 398 Z-score: 409.5 bits: 85.0 E(85289): 4.5e-16 Smith-Waterman score: 407; 25.6% identity (55.6% similar) in 410 aa overlap (58-408:45-442) 30 40 50 60 70 80 pF1KE0 LLNSSSVGNLSCEPPRIRGAGTRELELAIRITLYAVIFLMSVGGNMLIIVVLGLSRRLRT : ::. . :.. ::.::...: .: .: NP_001 TENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKT 20 30 40 50 60 70 90 100 110 120 130 140 pF1KE0 VTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVA ..: .. .:: ::.:... : :::: :. ..:: :.:. . .:. ::: :::: :.. NP_001 TVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILIS 80 90 100 110 120 130 150 160 170 180 190 200 pF1KE0 IALERYSAICRPLQARVWQTRSHAARVIVATWLLSGLLMVPYPVY-TVVQ---PVGPRVL ::. :: : .:.. . : .:. .:...: :. . : ::. ..:. : .: NP_001 IAIVRYHMIKHPISNNL--TANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALL 140 150 160 170 180 190 210 220 230 240 250 pF1KE0 Q----CVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGLISRELYLGLRFDGDSDSDS . ::. ::: : .... :::. ...: : ..:.. . : . :: :.. NP_001 SSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGL-------SNK 200 210 220 230 240 260 270 280 290 300 pF1KE0 QSRVRNQGGLPGAVHQNGRCRPETGAVGEDS----------------DGCYVQLPRSRPA ..:.... . ..: . . :.. : . .: . :. ::. NP_001 ENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPE-RPS 250 260 270 280 290 300 310 320 330 pF1KE0 LE----------------LTALTAPGPGSGS----RPTQA----KLLAKKRVVRM----- : :.. . :: . .: . .: .:. :.:. NP_001 QENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSR 310 320 330 340 350 360 340 350 360 370 380 pF1KE0 -----LLVIVVLFFLCWLPVYSANTWRAF-DGPGAHRALSGAPISFIHLLSYASACVNPL : .....: . :.:.. .. : :. ..: .. . . :::.. : :.::. NP_001 SVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLV-YCICHLLGMMSCCLNPI 370 380 390 400 410 420 390 400 410 420 430 440 pF1KE0 VYCFMHRRFRQACLETCARCCPRPPRARPRALPDEDPPTPSIASLSRLSYTTISTLGPG .: :.. .. : : . .: NP_001 LYGFLNNGIK-ADLVSLIHCLHM 430 440 >>XP_011530319 (OMIM: 602001) PREDICTED: neuropeptide Y (445 aa) initn: 430 init1: 252 opt: 398 Z-score: 409.5 bits: 85.0 E(85289): 4.5e-16 Smith-Waterman score: 407; 25.6% identity (55.6% similar) in 410 aa overlap (58-408:45-442) 30 40 50 60 70 80 pF1KE0 LLNSSSVGNLSCEPPRIRGAGTRELELAIRITLYAVIFLMSVGGNMLIIVVLGLSRRLRT : ::. . :.. ::.::...: .: .: XP_011 TENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKT 20 30 40 50 60 70 90 100 110 120 130 140 pF1KE0 VTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVA ..: .. .:: ::.:... : :::: :. ..:: :.:. . .:. ::: :::: :.. XP_011 TVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILIS 80 90 100 110 120 130 150 160 170 180 190 200 pF1KE0 IALERYSAICRPLQARVWQTRSHAARVIVATWLLSGLLMVPYPVY-TVVQ---PVGPRVL ::. :: : .:.. . : .:. .:...: :. . : ::. ..:. : .: XP_011 IAIVRYHMIKHPISNNL--TANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALL 140 150 160 170 180 190 210 220 230 240 250 pF1KE0 Q----CVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGLISRELYLGLRFDGDSDSDS . ::. ::: : .... :::. ...: : ..:.. . : . :: :.. XP_011 SSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGL-------SNK 200 210 220 230 240 260 270 280 290 300 pF1KE0 QSRVRNQGGLPGAVHQNGRCRPETGAVGEDS----------------DGCYVQLPRSRPA ..:.... . ..: . . :.. : . .: . :. ::. XP_011 ENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPE-RPS 250 260 270 280 290 300 310 320 330 pF1KE0 LE----------------LTALTAPGPGSGS----RPTQA----KLLAKKRVVRM----- : :.. . :: . .: . .: .:. :.:. XP_011 QENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSR 310 320 330 340 350 360 340 350 360 370 380 pF1KE0 -----LLVIVVLFFLCWLPVYSANTWRAF-DGPGAHRALSGAPISFIHLLSYASACVNPL : .....: . :.:.. .. : :. ..: .. . . :::.. : :.::. XP_011 SVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLV-YCICHLLGMMSCCLNPI 370 380 390 400 410 420 390 400 410 420 430 440 pF1KE0 VYCFMHRRFRQACLETCARCCPRPPRARPRALPDEDPPTPSIASLSRLSYTTISTLGPG .: :.. .. : : . .: XP_011 LYGFLNNGIK-ADLVSLIHCLHM 430 440 >>NP_001304021 (OMIM: 602001) neuropeptide Y receptor ty (445 aa) initn: 430 init1: 252 opt: 398 Z-score: 409.5 bits: 85.0 E(85289): 4.5e-16 Smith-Waterman score: 407; 25.6% identity (55.6% similar) in 410 aa overlap (58-408:45-442) 30 40 50 60 70 80 pF1KE0 LLNSSSVGNLSCEPPRIRGAGTRELELAIRITLYAVIFLMSVGGNMLIIVVLGLSRRLRT : ::. . :.. ::.::...: .: .: NP_001 TENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKT 20 30 40 50 60 70 90 100 110 120 130 140 pF1KE0 VTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVA ..: .. .:: ::.:... : :::: :. ..:: :.:. . .:. ::: :::: :.. NP_001 TVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILIS 80 90 100 110 120 130 150 160 170 180 190 200 pF1KE0 IALERYSAICRPLQARVWQTRSHAARVIVATWLLSGLLMVPYPVY-TVVQ---PVGPRVL ::. :: : .:.. . : .:. .:...: :. . : ::. ..:. : .: NP_001 IAIVRYHMIKHPISNNL--TANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALL 140 150 160 170 180 190 210 220 230 240 250 pF1KE0 Q----CVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGLISRELYLGLRFDGDSDSDS . ::. ::: : .... :::. ...: : ..:.. . : . :: :.. NP_001 SSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGL-------SNK 200 210 220 230 240 260 270 280 290 300 pF1KE0 QSRVRNQGGLPGAVHQNGRCRPETGAVGEDS----------------DGCYVQLPRSRPA ..:.... . ..: . . :.. : . .: . :. ::. NP_001 ENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPE-RPS 250 260 270 280 290 300 310 320 330 pF1KE0 LE----------------LTALTAPGPGSGS----RPTQA----KLLAKKRVVRM----- : :.. . :: . .: . .: .:. :.:. NP_001 QENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSR 310 320 330 340 350 360 340 350 360 370 380 pF1KE0 -----LLVIVVLFFLCWLPVYSANTWRAF-DGPGAHRALSGAPISFIHLLSYASACVNPL : .....: . :.:.. .. : :. ..: .. . . :::.. : :.::. NP_001 SVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLV-YCICHLLGMMSCCLNPI 370 380 390 400 410 420 390 400 410 420 430 440 pF1KE0 VYCFMHRRFRQACLETCARCCPRPPRARPRALPDEDPPTPSIASLSRLSYTTISTLGPG .: :.. .. : : . .: NP_001 LYGFLNNGIK-ADLVSLIHCLHM 430 440 447 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 18:17:37 2016 done: Sat Nov 5 18:17:38 2016 Total Scan time: 10.650 Total Display time: 0.080 Function used was FASTA [36.3.4 Apr, 2011]