FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0656, 388 aa 1>>>pF1KE0656 388 - 388 aa - 388 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.2507+/-0.000692; mu= 3.1917+/- 0.041 mean_var=588.4297+/-131.859, 0's: 0 Z-trim(113.4): 1941 B-trim: 799 in 1/52 Lambda= 0.052872 statistics sampled from 20268 (22676) to 20268 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.631), E-opt: 0.2 (0.266), width: 16 Scan time: 6.290 The best scores are: opt bits E(85289) XP_006721397 (OMIM: 612147) PREDICTED: myosin ligh ( 478) 1463 127.7 5.7e-29 NP_001295230 (OMIM: 612147) myosin light chain kin ( 478) 1463 127.7 5.7e-29 NP_872299 (OMIM: 612147) myosin light chain kinase ( 819) 1463 128.2 7.2e-29 NP_149109 (OMIM: 192600,606566) myosin light chain ( 596) 1244 111.2 6.7e-24 XP_016861959 (OMIM: 600922,613780) PREDICTED: myos ( 713) 984 91.5 6.7e-18 XP_016861960 (OMIM: 600922,613780) PREDICTED: myos ( 714) 984 91.5 6.7e-18 XP_016861958 (OMIM: 600922,613780) PREDICTED: myos ( 991) 984 91.8 7.8e-18 NP_001308238 (OMIM: 600922,613780) myosin light ch (1738) 984 92.2 9.9e-18 NP_444254 (OMIM: 600922,613780) myosin light chain (1845) 984 92.3 1e-17 XP_011511162 (OMIM: 600922,613780) PREDICTED: myos (1913) 984 92.3 1e-17 NP_444253 (OMIM: 600922,613780) myosin light chain (1914) 984 92.3 1e-17 XP_011519718 (OMIM: 616567) PREDICTED: death-assoc ( 488) 840 80.2 1.2e-14 XP_016877533 (OMIM: 616567) PREDICTED: death-assoc ( 350) 832 79.3 1.5e-14 XP_011519717 (OMIM: 616567) PREDICTED: death-assoc ( 359) 832 79.3 1.5e-14 NP_055141 (OMIM: 616567) death-associated protein ( 370) 832 79.4 1.6e-14 XP_011519716 (OMIM: 616567) PREDICTED: death-assoc ( 380) 832 79.4 1.6e-14 XP_011519715 (OMIM: 616567) PREDICTED: death-assoc ( 389) 832 79.4 1.6e-14 XP_005251814 (OMIM: 600831) PREDICTED: death-assoc ( 839) 823 79.4 3.6e-14 NP_004929 (OMIM: 600831) death-associated protein (1430) 823 79.8 4.5e-14 NP_001275659 (OMIM: 600831) death-associated prote (1430) 823 79.8 4.5e-14 NP_001275660 (OMIM: 600831) death-associated prote (1430) 823 79.8 4.5e-14 NP_001275658 (OMIM: 600831) death-associated prote (1430) 823 79.8 4.5e-14 NP_001339 (OMIM: 603289) death-associated protein ( 454) 790 76.3 1.6e-13 XP_005259565 (OMIM: 603289) PREDICTED: death-assoc ( 454) 790 76.3 1.6e-13 XP_011519719 (OMIM: 616567) PREDICTED: death-assoc ( 316) 780 75.3 2.3e-13 XP_016877535 (OMIM: 616567) PREDICTED: death-assoc ( 316) 780 75.3 2.3e-13 XP_016877534 (OMIM: 616567) PREDICTED: death-assoc ( 316) 780 75.3 2.3e-13 XP_011511163 (OMIM: 600922,613780) PREDICTED: myos (1846) 763 75.4 1.2e-12 NP_003310 (OMIM: 188840,600334,603689,604145,60880 (26926) 757 77.1 5.4e-12 XP_016860312 (OMIM: 188840,600334,603689,604145,60 (26973) 757 77.1 5.4e-12 NP_597676 (OMIM: 188840,600334,603689,604145,60880 (27051) 757 77.1 5.4e-12 NP_597681 (OMIM: 188840,600334,603689,604145,60880 (27118) 757 77.1 5.4e-12 XP_016860311 (OMIM: 188840,600334,603689,604145,60 (33101) 757 77.3 5.9e-12 NP_596869 (OMIM: 188840,600334,603689,604145,60880 (33423) 757 77.3 5.9e-12 XP_016860310 (OMIM: 188840,600334,603689,604145,60 (34087) 757 77.3 5.9e-12 XP_016860309 (OMIM: 188840,600334,603689,604145,60 (34088) 757 77.3 5.9e-12 NP_001243779 (OMIM: 188840,600334,603689,604145,60 (34350) 757 77.3 6e-12 XP_016860308 (OMIM: 188840,600334,603689,604145,60 (35622) 757 77.4 6e-12 NP_001254479 (OMIM: 188840,600334,603689,604145,60 (35991) 757 77.4 6.1e-12 NP_444256 (OMIM: 600922,613780) myosin light chain (1794) 721 72.2 1.1e-11 NP_444255 (OMIM: 600922,613780) myosin light chain (1863) 721 72.2 1.1e-11 NP_004751 (OMIM: 604726) serine/threonine-protein ( 414) 699 69.3 1.9e-11 NP_004217 (OMIM: 604727) serine/threonine-protein ( 372) 678 67.6 5.4e-11 XP_011510470 (OMIM: 604727) PREDICTED: serine/thre ( 372) 678 67.6 5.4e-11 XP_011510471 (OMIM: 604727) PREDICTED: serine/thre ( 372) 678 67.6 5.4e-11 XP_011510472 (OMIM: 604727) PREDICTED: serine/thre ( 372) 678 67.6 5.4e-11 XP_006717546 (OMIM: 607957) PREDICTED: calcium/cal ( 355) 668 66.8 9e-11 NP_065130 (OMIM: 607957) calcium/calmodulin-depend ( 357) 668 66.8 9e-11 XP_006717545 (OMIM: 607957) PREDICTED: calcium/cal ( 362) 668 66.8 9e-11 NP_705718 (OMIM: 607957) calcium/calmodulin-depend ( 385) 668 66.9 9.3e-11 >>XP_006721397 (OMIM: 612147) PREDICTED: myosin light ch (478 aa) initn: 1453 init1: 1453 opt: 1463 Z-score: 641.1 bits: 127.7 E(85289): 5.7e-29 Smith-Waterman score: 1463; 63.1% identity (85.5% similar) in 339 aa overlap (40-373:108-446) 10 20 30 40 50 60 pF1KE0 FNTCYNSNQLEKMAFFQCREEVEKVKCFLEKNSGDQDSRSGHNEAKEVWSNADLTERMPV :. : . . .. : .. :. ..::: XP_006 RAGAEPGTRPSLARSDDNDHEVGALGLQQGKSPGAGNPEPEQDCAARAPVRAEAVRRMPP 80 90 100 110 120 130 70 80 90 100 110 120 pF1KE0 KSKRTSALAVDIPAPPAPFDHRIVTAKQGAVNSFYTVSKTEILGGGRFGQVHKCEETATG .. :.. : :::::::.::.:..:. .... : : . :.::::::::::.: : .:: XP_006 GAEAGSVVLDDSPAPPAPFEHRVVSVKETSISAGYEVCQHEVLGGGRFGQVHRCTEKSTG 140 150 160 170 180 190 130 140 150 160 170 180 pF1KE0 LKLAAKIIKTRGMKDKEEVKNEISVMNQLDHANLIQLYDAFESKNDIVLVMEYVDGGELF : :::::::... ::.:.:::::..::::.:.::::::::::::.. .:::::::::::: XP_006 LPLAAKIIKVKSAKDREDVKNEINIMNQLSHVNLIQLYDAFESKHSCTLVMEYVDGGELF 200 210 220 230 240 250 190 200 210 220 230 240 pF1KE0 DRIIDESYNLTELDTILFMKQICEGIRHMHQMYILHLDLKPENILCVNRDAKQIKIIDFG ::: ::.:.:::::..:: .:::::....:: ::::::::::::::::. ..:::::::: XP_006 DRITDEKYHLTELDVVLFTRQICEGVHYLHQHYILHLDLKPENILCVNQTGHQIKIIDFG 260 270 280 290 300 310 250 260 270 280 290 300 pF1KE0 LARRYKPREKLKVNFGTPEFLAPEVVNYDFVSFPTDMWSVGVIAYMLLSGLSPFLGDNDA ::::::::::::::::::::::::::::.::::::::::::::.::::::::::::..:: XP_006 LARRYKPREKLKVNFGTPEFLAPEVVNYEFVSFPTDMWSVGVITYMLLSGLSPFLGETDA 320 330 340 350 360 370 310 320 330 340 350 360 pF1KE0 ETLNNILACRWDLEDEEFQDISEEAKEFISKLLIKEKSWRISASEALKHPWLSD-----H ::.: :. : ::.. . :. .:::::.:.:.::.:::: :.::.. ::: ::.. XP_006 ETMNFIVNCSWDFDADTFEGLSEEAKDFVSRLLVKEKSCRMSATQCLKHEWLNNLPAKAS 380 390 400 410 420 430 370 380 pF1KE0 KLHSRLNAQKKKNRGSDAQDFVTK . ..::..: XP_006 RSKTRLKSQLLLQKYIAQRKWKKHFYVVTAANRLRKFPTSP 440 450 460 470 >>NP_001295230 (OMIM: 612147) myosin light chain kinase (478 aa) initn: 1453 init1: 1453 opt: 1463 Z-score: 641.1 bits: 127.7 E(85289): 5.7e-29 Smith-Waterman score: 1463; 63.1% identity (85.5% similar) in 339 aa overlap (40-373:108-446) 10 20 30 40 50 60 pF1KE0 FNTCYNSNQLEKMAFFQCREEVEKVKCFLEKNSGDQDSRSGHNEAKEVWSNADLTERMPV :. : . . .. : .. :. ..::: NP_001 RAGAEPGTRPSLARSDDNDHEVGALGLQQGKSPGAGNPEPEQDCAARAPVRAEAVRRMPP 80 90 100 110 120 130 70 80 90 100 110 120 pF1KE0 KSKRTSALAVDIPAPPAPFDHRIVTAKQGAVNSFYTVSKTEILGGGRFGQVHKCEETATG .. :.. : :::::::.::.:..:. .... : : . :.::::::::::.: : .:: NP_001 GAEAGSVVLDDSPAPPAPFEHRVVSVKETSISAGYEVCQHEVLGGGRFGQVHRCTEKSTG 140 150 160 170 180 190 130 140 150 160 170 180 pF1KE0 LKLAAKIIKTRGMKDKEEVKNEISVMNQLDHANLIQLYDAFESKNDIVLVMEYVDGGELF : :::::::... ::.:.:::::..::::.:.::::::::::::.. .:::::::::::: NP_001 LPLAAKIIKVKSAKDREDVKNEINIMNQLSHVNLIQLYDAFESKHSCTLVMEYVDGGELF 200 210 220 230 240 250 190 200 210 220 230 240 pF1KE0 DRIIDESYNLTELDTILFMKQICEGIRHMHQMYILHLDLKPENILCVNRDAKQIKIIDFG ::: ::.:.:::::..:: .:::::....:: ::::::::::::::::. ..:::::::: NP_001 DRITDEKYHLTELDVVLFTRQICEGVHYLHQHYILHLDLKPENILCVNQTGHQIKIIDFG 260 270 280 290 300 310 250 260 270 280 290 300 pF1KE0 LARRYKPREKLKVNFGTPEFLAPEVVNYDFVSFPTDMWSVGVIAYMLLSGLSPFLGDNDA ::::::::::::::::::::::::::::.::::::::::::::.::::::::::::..:: NP_001 LARRYKPREKLKVNFGTPEFLAPEVVNYEFVSFPTDMWSVGVITYMLLSGLSPFLGETDA 320 330 340 350 360 370 310 320 330 340 350 360 pF1KE0 ETLNNILACRWDLEDEEFQDISEEAKEFISKLLIKEKSWRISASEALKHPWLSD-----H ::.: :. : ::.. . :. .:::::.:.:.::.:::: :.::.. ::: ::.. NP_001 ETMNFIVNCSWDFDADTFEGLSEEAKDFVSRLLVKEKSCRMSATQCLKHEWLNNLPAKAS 380 390 400 410 420 430 370 380 pF1KE0 KLHSRLNAQKKKNRGSDAQDFVTK . ..::..: NP_001 RSKTRLKSQLLLQKYIAQRKWKKHFYVVTAANRLRKFPTSP 440 450 460 470 >>NP_872299 (OMIM: 612147) myosin light chain kinase 3 i (819 aa) initn: 1453 init1: 1453 opt: 1463 Z-score: 639.3 bits: 128.2 E(85289): 7.2e-29 Smith-Waterman score: 1463; 63.1% identity (85.5% similar) in 339 aa overlap (40-373:449-787) 10 20 30 40 50 60 pF1KE0 FNTCYNSNQLEKMAFFQCREEVEKVKCFLEKNSGDQDSRSGHNEAKEVWSNADLTERMPV :. : . . .. : .. :. ..::: NP_872 RAGAEPGTRPSLARSDDNDHEVGALGLQQGKSPGAGNPEPEQDCAARAPVRAEAVRRMPP 420 430 440 450 460 470 70 80 90 100 110 120 pF1KE0 KSKRTSALAVDIPAPPAPFDHRIVTAKQGAVNSFYTVSKTEILGGGRFGQVHKCEETATG .. :.. : :::::::.::.:..:. .... : : . :.::::::::::.: : .:: NP_872 GAEAGSVVLDDSPAPPAPFEHRVVSVKETSISAGYEVCQHEVLGGGRFGQVHRCTEKSTG 480 490 500 510 520 530 130 140 150 160 170 180 pF1KE0 LKLAAKIIKTRGMKDKEEVKNEISVMNQLDHANLIQLYDAFESKNDIVLVMEYVDGGELF : :::::::... ::.:.:::::..::::.:.::::::::::::.. .:::::::::::: NP_872 LPLAAKIIKVKSAKDREDVKNEINIMNQLSHVNLIQLYDAFESKHSCTLVMEYVDGGELF 540 550 560 570 580 590 190 200 210 220 230 240 pF1KE0 DRIIDESYNLTELDTILFMKQICEGIRHMHQMYILHLDLKPENILCVNRDAKQIKIIDFG ::: ::.:.:::::..:: .:::::....:: ::::::::::::::::. ..:::::::: NP_872 DRITDEKYHLTELDVVLFTRQICEGVHYLHQHYILHLDLKPENILCVNQTGHQIKIIDFG 600 610 620 630 640 650 250 260 270 280 290 300 pF1KE0 LARRYKPREKLKVNFGTPEFLAPEVVNYDFVSFPTDMWSVGVIAYMLLSGLSPFLGDNDA ::::::::::::::::::::::::::::.::::::::::::::.::::::::::::..:: NP_872 LARRYKPREKLKVNFGTPEFLAPEVVNYEFVSFPTDMWSVGVITYMLLSGLSPFLGETDA 660 670 680 690 700 710 310 320 330 340 350 360 pF1KE0 ETLNNILACRWDLEDEEFQDISEEAKEFISKLLIKEKSWRISASEALKHPWLSD-----H ::.: :. : ::.. . :. .:::::.:.:.::.:::: :.::.. ::: ::.. NP_872 ETMNFIVNCSWDFDADTFEGLSEEAKDFVSRLLVKEKSCRMSATQCLKHEWLNNLPAKAS 720 730 740 750 760 770 370 380 pF1KE0 KLHSRLNAQKKKNRGSDAQDFVTK . ..::..: NP_872 RSKTRLKSQLLLQKYIAQRKWKKHFYVVTAANRLRKFPTSP 780 790 800 810 >>NP_149109 (OMIM: 192600,606566) myosin light chain kin (596 aa) initn: 1228 init1: 1228 opt: 1244 Z-score: 550.1 bits: 111.2 E(85289): 6.7e-24 Smith-Waterman score: 1244; 60.5% identity (82.6% similar) in 299 aa overlap (80-373:259-557) 50 60 70 80 90 100 pF1KE0 GHNEAKEVWSNADLTERMPVKSKRTSALAVDIPAPPAPFDHRIVTAKQGAVNSFYTVSKT : : ::::: ::.: . : :.: ..... NP_149 EFQAVPSEKSEVGQALCLTAREEDCFQILDDCPPPPAPFPHRMVELRTGNVSSEFSMNSK 230 240 250 260 270 280 110 120 130 140 150 160 pF1KE0 EILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEEVKNEISVMNQLDHANLIQLYDA : ::::.:: : : : :::::::::.:: . :::: : :: :::::.: :::::: : NP_149 EALGGGKFGAVCTCMEKATGLKLAAKVIKKQTPKDKEMVLLEIEVMNQLNHRNLIQLYAA 290 300 310 320 330 340 170 180 190 200 210 220 pF1KE0 FESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYILHLDLK .:. ..::: :::..:::::.::.::.:.:::.::..:..:::.:: ::.: .:::::: NP_149 IETPHEIVLFMEYIEGGELFERIVDEDYHLTEVDTMVFVRQICDGILFMHKMRVLHLDLK 350 360 370 380 390 400 230 240 250 260 270 280 pF1KE0 PENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYDFVSFPTDMWSV :::::::: .. .:::::::::::.: :::::::::::::.::::::: .: :::::. NP_149 PENILCVNTTGHLVKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQISDKTDMWSM 410 420 430 440 450 460 290 300 310 320 330 340 pF1KE0 GVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKEFISKLLIKEKSWR :::.:::::::::::::.:.:::::.:. : ...: :. .:.:::.:.:.:..:.. : NP_149 GVITYMLLSGLSPFLGDDDTETLNNVLSGNWYFDEETFEAVSDEAKDFVSNLIVKDQRAR 470 480 490 500 510 520 350 360 370 380 pF1KE0 ISASEALKHPWLSD-----HKLHSRLNAQKKKNRGSDAQDFVTK ..:.. : ::::.. .. . ::..: NP_149 MNAAQCLAHPWLNNLAEKAKRCNRRLKSQILLKKYLMKRRWKKNFIAVSAANRFKKISSS 530 540 550 560 570 580 >>XP_016861959 (OMIM: 600922,613780) PREDICTED: myosin l (713 aa) initn: 989 init1: 957 opt: 984 Z-score: 442.3 bits: 91.5 E(85289): 6.7e-18 Smith-Waterman score: 984; 49.2% identity (75.7% similar) in 313 aa overlap (68-378:228-535) 40 50 60 70 80 90 pF1KE0 LEKNSGDQDSRSGHNEAKEVWSNADLTERMPVKSKRTSALAVDIPAPPAPFDHRIVTAK- : . : .. : : :.: :: . XP_016 HEYKFRVRAINVYGTSEPSQESELTTVGEKPEEPKDEVEVSDDDEKEPE-VDYRTVTINT 200 210 220 230 240 250 100 110 120 130 140 150 pF1KE0 QGAVNSFYTVSKTEILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEEVKNEISVMN . :..:: . : ::.:.:::: . : : :.:..:. . :.::....:::.:: XP_016 EQKVSDFYDIE--ERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISIMN 260 270 280 290 300 310 160 170 180 190 200 210 pF1KE0 QLDHANLIQLYDAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIR : : .:.: :::: : .::.:.: :.:::::.:::::...::: . : .:.:: ::.. XP_016 CLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVE 320 330 340 350 360 370 220 230 240 250 260 270 pF1KE0 HMHQMYILHLDLKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVN ..:.. :.:::::::::.:::. . .::.:::::::: . .::: ::::::.::::.: XP_016 YIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRLENAGSLKVLFGTPEFVAPEVIN 380 390 400 410 420 430 280 290 300 310 320 330 pF1KE0 YDFVSFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKE :. ... :::::.::: :.:.::::::.:::: ::: :. . ::..:: :..::..::. XP_016 YEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKD 440 450 460 470 480 490 340 350 360 370 380 pF1KE0 FISKLLIKEKSWRISASEALKHPWLSDHKLHSRLNAQK-KKNRGSDAQDFVTK :::.:: :. . :.. .. :.:::: : . ..:.: .:.: XP_016 FISNLLKKDMKNRLDCTQCLQHPWL--MKDTKNMEAKKLSKDRMKKYMARRKWQKTGNAV 500 510 520 530 540 550 XP_016 RAIGRLSSMAMISGLSGRKSSTGSPTSPLNAEKLESEDVSQAFLEAVAEEKPHVKPYFSK 560 570 580 590 600 610 >>XP_016861960 (OMIM: 600922,613780) PREDICTED: myosin l (714 aa) initn: 989 init1: 957 opt: 984 Z-score: 442.3 bits: 91.5 E(85289): 6.7e-18 Smith-Waterman score: 984; 49.2% identity (75.7% similar) in 313 aa overlap (68-378:228-535) 40 50 60 70 80 90 pF1KE0 LEKNSGDQDSRSGHNEAKEVWSNADLTERMPVKSKRTSALAVDIPAPPAPFDHRIVTAK- : . : .. : : :.: :: . XP_016 HEYKFRVRAINVYGTSEPSQESELTTVGEKPEEPKDEVEVSDDDEKEPE-VDYRTVTINT 200 210 220 230 240 250 100 110 120 130 140 150 pF1KE0 QGAVNSFYTVSKTEILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEEVKNEISVMN . :..:: . : ::.:.:::: . : : :.:..:. . :.::....:::.:: XP_016 EQKVSDFYDIE--ERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISIMN 260 270 280 290 300 310 160 170 180 190 200 210 pF1KE0 QLDHANLIQLYDAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIR : : .:.: :::: : .::.:.: :.:::::.:::::...::: . : .:.:: ::.. XP_016 CLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVE 320 330 340 350 360 370 220 230 240 250 260 270 pF1KE0 HMHQMYILHLDLKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVN ..:.. :.:::::::::.:::. . .::.:::::::: . .::: ::::::.::::.: XP_016 YIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRLENAGSLKVLFGTPEFVAPEVIN 380 390 400 410 420 430 280 290 300 310 320 330 pF1KE0 YDFVSFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKE :. ... :::::.::: :.:.::::::.:::: ::: :. . ::..:: :..::..::. XP_016 YEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKD 440 450 460 470 480 490 340 350 360 370 380 pF1KE0 FISKLLIKEKSWRISASEALKHPWLSDHKLHSRLNAQK-KKNRGSDAQDFVTK :::.:: :. . :.. .. :.:::: : . ..:.: .:.: XP_016 FISNLLKKDMKNRLDCTQCLQHPWL--MKDTKNMEAKKLSKDRMKKYMARRKWQKTGNAV 500 510 520 530 540 550 XP_016 RAIGRLSSMAMISGLSGRKSSTGSPTSPLNAEKLESEEDVSQAFLEAVAEEKPHVKPYFS 560 570 580 590 600 610 >>XP_016861958 (OMIM: 600922,613780) PREDICTED: myosin l (991 aa) initn: 989 init1: 957 opt: 984 Z-score: 441.2 bits: 91.8 E(85289): 7.8e-18 Smith-Waterman score: 984; 49.2% identity (75.7% similar) in 313 aa overlap (68-378:506-813) 40 50 60 70 80 90 pF1KE0 LEKNSGDQDSRSGHNEAKEVWSNADLTERMPVKSKRTSALAVDIPAPPAPFDHRIVTAK- : . : .. : : :.: :: . XP_016 HEYKFRVRAINVYGTSEPSQESELTTVGEKPEEPKDEVEVSDDDEKEPE-VDYRTVTINT 480 490 500 510 520 530 100 110 120 130 140 150 pF1KE0 QGAVNSFYTVSKTEILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEEVKNEISVMN . :..:: . : ::.:.:::: . : : :.:..:. . :.::....:::.:: XP_016 EQKVSDFYDIE--ERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISIMN 540 550 560 570 580 590 160 170 180 190 200 210 pF1KE0 QLDHANLIQLYDAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIR : : .:.: :::: : .::.:.: :.:::::.:::::...::: . : .:.:: ::.. XP_016 CLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVE 600 610 620 630 640 650 220 230 240 250 260 270 pF1KE0 HMHQMYILHLDLKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVN ..:.. :.:::::::::.:::. . .::.:::::::: . .::: ::::::.::::.: XP_016 YIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRLENAGSLKVLFGTPEFVAPEVIN 660 670 680 690 700 710 280 290 300 310 320 330 pF1KE0 YDFVSFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKE :. ... :::::.::: :.:.::::::.:::: ::: :. . ::..:: :..::..::. XP_016 YEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKD 720 730 740 750 760 770 340 350 360 370 380 pF1KE0 FISKLLIKEKSWRISASEALKHPWLSDHKLHSRLNAQK-KKNRGSDAQDFVTK :::.:: :. . :.. .. :.:::: : . ..:.: .:.: XP_016 FISNLLKKDMKNRLDCTQCLQHPWL--MKDTKNMEAKKLSKDRMKKYMARRKWQKTGNAV 780 790 800 810 820 830 XP_016 RAIGRLSSMAMISGLSGRKSSTGSPTSPLNAEKLESEDVSQAFLEAVAEEKPHVKPYFSK 840 850 860 870 880 890 >>NP_001308238 (OMIM: 600922,613780) myosin light chain (1738 aa) initn: 1016 init1: 957 opt: 984 Z-score: 439.3 bits: 92.2 E(85289): 9.9e-18 Smith-Waterman score: 984; 49.2% identity (75.7% similar) in 313 aa overlap (68-378:1252-1559) 40 50 60 70 80 90 pF1KE0 LEKNSGDQDSRSGHNEAKEVWSNADLTERMPVKSKRTSALAVDIPAPPAPFDHRIVTAK- : . : .. : : :.: :: . NP_001 HEYKFRVRAINVYGTSEPSQESELTTVGEKPEEPKDEVEVSDDDEKEPE-VDYRTVTINT 1230 1240 1250 1260 1270 1280 100 110 120 130 140 150 pF1KE0 QGAVNSFYTVSKTEILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEEVKNEISVMN . :..:: . : ::.:.:::: . : : :.:..:. . :.::....:::.:: NP_001 EQKVSDFYDIE--ERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISIMN 1290 1300 1310 1320 1330 160 170 180 190 200 210 pF1KE0 QLDHANLIQLYDAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIR : : .:.: :::: : .::.:.: :.:::::.:::::...::: . : .:.:: ::.. NP_001 CLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVE 1340 1350 1360 1370 1380 1390 220 230 240 250 260 270 pF1KE0 HMHQMYILHLDLKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVN ..:.. :.:::::::::.:::. . .::.:::::::: . .::: ::::::.::::.: NP_001 YIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRLENAGSLKVLFGTPEFVAPEVIN 1400 1410 1420 1430 1440 1450 280 290 300 310 320 330 pF1KE0 YDFVSFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKE :. ... :::::.::: :.:.::::::.:::: ::: :. . ::..:: :..::..::. NP_001 YEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKD 1460 1470 1480 1490 1500 1510 340 350 360 370 380 pF1KE0 FISKLLIKEKSWRISASEALKHPWLSDHKLHSRLNAQK-KKNRGSDAQDFVTK :::.:: :. . :.. .. :.:::: : . ..:.: .:.: NP_001 FISNLLKKDMKNRLDCTQCLQHPWL--MKDTKNMEAKKLSKDRMKKYMARRKWQKTGNAV 1520 1530 1540 1550 1560 1570 NP_001 RAIGRLSSMAMISGLSGRKSSTGSPTSPLNAEKLESEEDVSQAFLEAVAEEKPHVKPYFS 1580 1590 1600 1610 1620 1630 >>NP_444254 (OMIM: 600922,613780) myosin light chain kin (1845 aa) initn: 1016 init1: 957 opt: 984 Z-score: 439.1 bits: 92.3 E(85289): 1e-17 Smith-Waterman score: 984; 49.2% identity (75.7% similar) in 313 aa overlap (68-378:1359-1666) 40 50 60 70 80 90 pF1KE0 LEKNSGDQDSRSGHNEAKEVWSNADLTERMPVKSKRTSALAVDIPAPPAPFDHRIVTAK- : . : .. : : :.: :: . NP_444 HEYKFRVRAINVYGTSEPSQESELTTVGEKPEEPKDEVEVSDDDEKEPE-VDYRTVTINT 1330 1340 1350 1360 1370 1380 100 110 120 130 140 150 pF1KE0 QGAVNSFYTVSKTEILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEEVKNEISVMN . :..:: . : ::.:.:::: . : : :.:..:. . :.::....:::.:: NP_444 EQKVSDFYDIE--ERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISIMN 1390 1400 1410 1420 1430 1440 160 170 180 190 200 210 pF1KE0 QLDHANLIQLYDAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIR : : .:.: :::: : .::.:.: :.:::::.:::::...::: . : .:.:: ::.. NP_444 CLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVE 1450 1460 1470 1480 1490 1500 220 230 240 250 260 270 pF1KE0 HMHQMYILHLDLKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVN ..:.. :.:::::::::.:::. . .::.:::::::: . .::: ::::::.::::.: NP_444 YIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRLENAGSLKVLFGTPEFVAPEVIN 1510 1520 1530 1540 1550 1560 280 290 300 310 320 330 pF1KE0 YDFVSFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKE :. ... :::::.::: :.:.::::::.:::: ::: :. . ::..:: :..::..::. NP_444 YEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKD 1570 1580 1590 1600 1610 1620 340 350 360 370 380 pF1KE0 FISKLLIKEKSWRISASEALKHPWLSDHKLHSRLNAQK-KKNRGSDAQDFVTK :::.:: :. . :.. .. :.:::: : . ..:.: .:.: NP_444 FISNLLKKDMKNRLDCTQCLQHPWL--MKDTKNMEAKKLSKDRMKKYMARRKWQKTGNAV 1630 1640 1650 1660 1670 1680 NP_444 RAIGRLSSMAMISGLSGRKSSTGSPTSPLNAEKLESEEDVSQAFLEAVAEEKPHVKPYFS 1690 1700 1710 1720 1730 1740 >>XP_011511162 (OMIM: 600922,613780) PREDICTED: myosin l (1913 aa) initn: 1016 init1: 957 opt: 984 Z-score: 439.0 bits: 92.3 E(85289): 1e-17 Smith-Waterman score: 984; 49.2% identity (75.7% similar) in 313 aa overlap (68-378:1428-1735) 40 50 60 70 80 90 pF1KE0 LEKNSGDQDSRSGHNEAKEVWSNADLTERMPVKSKRTSALAVDIPAPPAPFDHRIVTAK- : . : .. : : :.: :: . XP_011 HEYKFRVRAINVYGTSEPSQESELTTVGEKPEEPKDEVEVSDDDEKEPE-VDYRTVTINT 1400 1410 1420 1430 1440 1450 100 110 120 130 140 150 pF1KE0 QGAVNSFYTVSKTEILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEEVKNEISVMN . :..:: . : ::.:.:::: . : : :.:..:. . :.::....:::.:: XP_011 EQKVSDFYDIE--ERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISIMN 1460 1470 1480 1490 1500 1510 160 170 180 190 200 210 pF1KE0 QLDHANLIQLYDAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIR : : .:.: :::: : .::.:.: :.:::::.:::::...::: . : .:.:: ::.. XP_011 CLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVE 1520 1530 1540 1550 1560 1570 220 230 240 250 260 270 pF1KE0 HMHQMYILHLDLKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVN ..:.. :.:::::::::.:::. . .::.:::::::: . .::: ::::::.::::.: XP_011 YIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRLENAGSLKVLFGTPEFVAPEVIN 1580 1590 1600 1610 1620 1630 280 290 300 310 320 330 pF1KE0 YDFVSFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKE :. ... :::::.::: :.:.::::::.:::: ::: :. . ::..:: :..::..::. XP_011 YEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKD 1640 1650 1660 1670 1680 1690 340 350 360 370 380 pF1KE0 FISKLLIKEKSWRISASEALKHPWLSDHKLHSRLNAQK-KKNRGSDAQDFVTK :::.:: :. . :.. .. :.:::: : . ..:.: .:.: XP_011 FISNLLKKDMKNRLDCTQCLQHPWL--MKDTKNMEAKKLSKDRMKKYMARRKWQKTGNAV 1700 1710 1720 1730 1740 1750 XP_011 RAIGRLSSMAMISGLSGRKSSTGSPTSPLNAEKLESEDVSQAFLEAVAEEKPHVKPYFSK 1760 1770 1780 1790 1800 1810 388 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Wed Nov 2 18:43:18 2016 done: Wed Nov 2 18:43:19 2016 Total Scan time: 6.290 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]