FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0667, 243 aa 1>>>pF1KE0667 243 - 243 aa - 243 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.4672+/-0.000595; mu= 9.6747+/- 0.036 mean_var=98.1739+/-19.822, 0's: 0 Z-trim(114.4): 16 B-trim: 0 in 0/53 Lambda= 0.129442 statistics sampled from 14944 (14960) to 14944 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.801), E-opt: 0.2 (0.46), width: 16 Scan time: 2.420 The best scores are: opt bits E(32554) CCDS59023.1 RCAN2 gene_id:10231|Hs108|chr6 ( 243) 1679 322.9 1.2e-88 CCDS43469.1 RCAN2 gene_id:10231|Hs108|chr6 ( 197) 1189 231.4 3.5e-61 CCDS254.1 RCAN3 gene_id:11123|Hs108|chr1 ( 241) 942 185.3 3.2e-47 CCDS13637.1 RCAN1 gene_id:1827|Hs108|chr21 ( 252) 808 160.3 1.1e-39 CCDS33551.1 RCAN1 gene_id:1827|Hs108|chr21 ( 197) 805 159.6 1.4e-39 CCDS74788.1 RCAN1 gene_id:1827|Hs108|chr21 ( 277) 764 152.1 3.7e-37 CCDS74790.1 RCAN1 gene_id:1827|Hs108|chr21 ( 171) 754 150.1 8.9e-37 CCDS82668.1 RCAN1 gene_id:1827|Hs108|chr21 ( 205) 619 124.9 4e-29 CCDS42921.1 RCAN1 gene_id:1827|Hs108|chr21 ( 117) 516 105.6 1.6e-23 CCDS57981.1 RCAN3 gene_id:11123|Hs108|chr1 ( 183) 509 104.4 5.6e-23 CCDS72730.1 RCAN3 gene_id:11123|Hs108|chr1 ( 116) 500 102.6 1.2e-22 CCDS57979.1 RCAN3 gene_id:11123|Hs108|chr1 ( 231) 455 94.3 7.4e-20 CCDS57980.1 RCAN3 gene_id:11123|Hs108|chr1 ( 173) 443 92.0 2.7e-19 >>CCDS59023.1 RCAN2 gene_id:10231|Hs108|chr6 (243 aa) initn: 1679 init1: 1679 opt: 1679 Z-score: 1705.0 bits: 322.9 E(32554): 1.2e-88 Smith-Waterman score: 1679; 100.0% identity (100.0% similar) in 243 aa overlap (1-243:1-243) 10 20 30 40 50 60 pF1KE0 MRGESYFIGMRSPGQQGHVPEDGGLFLLCCIDRDWAVTRCFAEEAFQAITDFNDLPNSLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 MRGESYFIGMRSPGQQGHVPEDGGLFLLCCIDRDWAVTRCFAEEAFQAITDFNDLPNSLF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 ACNVHQSVFEGEESKEKFEGLFRTYDDCVTFQLFKSFRRVRINFSNPKSAARARIELHET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 ACNVHQSVFEGEESKEKFEGLFRTYDDCVTFQLFKSFRRVRINFSNPKSAARARIELHET 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 QFRGKKLKLYFAQVQTPETDGDKLHLAPPQPAKQFLISPPSSPPVGWQPINDATPVLNYD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 QFRGKKLKLYFAQVQTPETDGDKLHLAPPQPAKQFLISPPSSPPVGWQPINDATPVLNYD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 LLYAVAKLGPGEKYELHAGTESTPSVVVHVCDSDIEEEEDPKTSPKPKIIQTRRPGLPPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 LLYAVAKLGPGEKYELHAGTESTPSVVVHVCDSDIEEEEDPKTSPKPKIIQTRRPGLPPS 190 200 210 220 230 240 pF1KE0 VSN ::: CCDS59 VSN >>CCDS43469.1 RCAN2 gene_id:10231|Hs108|chr6 (197 aa) initn: 1189 init1: 1189 opt: 1189 Z-score: 1211.8 bits: 231.4 E(32554): 3.5e-61 Smith-Waterman score: 1189; 94.1% identity (96.3% similar) in 187 aa overlap (57-243:11-197) 30 40 50 60 70 80 pF1KE0 LLCCIDRDWAVTRCFAEEAFQAITDFNDLPNSLFACNVHQSVFEGEESKEKFEGLFRTYD ..: :: : :: ..: :::::::::::: CCDS43 MPAPSMDCDVSTLVACVVDVEVFTNQEVKEKFEGLFRTYD 10 20 30 40 90 100 110 120 130 140 pF1KE0 DCVTFQLFKSFRRVRINFSNPKSAARARIELHETQFRGKKLKLYFAQVQTPETDGDKLHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 DCVTFQLFKSFRRVRINFSNPKSAARARIELHETQFRGKKLKLYFAQVQTPETDGDKLHL 50 60 70 80 90 100 150 160 170 180 190 200 pF1KE0 APPQPAKQFLISPPSSPPVGWQPINDATPVLNYDLLYAVAKLGPGEKYELHAGTESTPSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 APPQPAKQFLISPPSSPPVGWQPINDATPVLNYDLLYAVAKLGPGEKYELHAGTESTPSV 110 120 130 140 150 160 210 220 230 240 pF1KE0 VVHVCDSDIEEEEDPKTSPKPKIIQTRRPGLPPSVSN ::::::::::::::::::::::::::::::::::::: CCDS43 VVHVCDSDIEEEEDPKTSPKPKIIQTRRPGLPPSVSN 170 180 190 >>CCDS254.1 RCAN3 gene_id:11123|Hs108|chr1 (241 aa) initn: 856 init1: 856 opt: 942 Z-score: 961.2 bits: 185.3 E(32554): 3.2e-47 Smith-Waterman score: 942; 66.4% identity (83.4% similar) in 217 aa overlap (28-242:16-230) 10 20 30 40 50 pF1KE0 MRGESYFIGMRSPGQQGHVPEDGGLFLLCCIDRDWAVTRCFAE--EAFQAITDFNDLPNS :: :.. :.: . .. . :..:::.: CCDS25 MLRDTMKSWNDSQSDLCSTDQEEEEEMIFGENEDDLDEMMDLSDLPTS 10 20 30 40 60 70 80 90 100 110 pF1KE0 LFACNVHQSVFEGEESKEKFEGLFRTYDDCVTFQLFKSFRRVRINFSNPKSAARARIELH ::::.::..:::..:.::.::.:: ::: :::::::::::::::::.:..::::::::: CCDS25 LFACSVHEAVFEAREQKERFEALFTIYDDQVTFQLFKSFRRVRINFSKPEAAARARIELH 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE0 ETQFRGKKLKLYFAQVQTPETDGDKLHLAPPQPAKQFLISPPSSPPVGWQPINDATPVLN ::.: :.:::::::::: :: .: ::::.::::::::.::::::. .:: ::.: CCDS25 ETDFNGQKLKLYFAQVQMSGEVRDKSYLLPPQPVKQFLISPPASPPVGWKQSEDAMPVIN 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE0 YDLLYAVAKLGPGEKYELHAGTESTPSVVVHVCDSDIEEEEDPKTSPKPKIIQTRRPGLP :::: ::.:::::::::::::::::::::::::.:. ::::. : .:: :: ::::: : CCDS25 YDLLCAVSKLGPGEKYELHAGTESTPSVVVHVCESETEEEEETK-NPKQKIAQTRRPD-P 170 180 190 200 210 220 240 pF1KE0 PSVSN :... CCDS25 PTAALNEPQTFDCAL 230 240 >>CCDS13637.1 RCAN1 gene_id:1827|Hs108|chr21 (252 aa) initn: 464 init1: 437 opt: 808 Z-score: 825.7 bits: 160.3 E(32554): 1.1e-39 Smith-Waterman score: 829; 60.0% identity (77.6% similar) in 210 aa overlap (34-239:48-248) 10 20 30 40 50 60 pF1KE0 ESYFIGMRSPGQQGHVPEDGGLFLLCCIDRDWAVTRCFAEEAFQAITDFNDLPNSLFACN ::. : ::. :..:::.. .::. CCDS13 EAAEARARPGVTLRPFAPLSGAAEADEGGGDWSFIDCEMEEV-----DLQDLPSATIACH 20 30 40 50 60 70 70 80 90 100 110 120 pF1KE0 VHQSVFEGEESKEKFEGLFRTYDDCVTFQLFKSFRRVRINFSNPKSAARARIELHETQFR . :: . :::.:::::: .::: ::::.::::::::: ::: ::..::.:.: CCDS13 LDPRVFVDGLCRAKFESLFRTYDKDITFQYFKSFKRVRINFSNPFSAADARLQLHKTEFL 80 90 100 110 120 130 130 140 150 160 170 180 pF1KE0 GKKLKLYFAQVQTPETDGDKLHLAPPQPAKQFLISPPSSPPVGWQPINDATPVLNYDLLY ::..::::::. .. :::::.: ::::::::.::::::. ..:::::.:::::: CCDS13 GKEMKLYFAQTLHIGSS----HLAPPNPDKQFLISPPASPPVGWKQVEDATPVINYDLLY 140 150 160 170 180 190 200 210 220 230 pF1KE0 AVAKLGPGEKYELHAGTESTPSVVVHVCDSDIEEEEDPKTS----PKPKIIQTRRPGLPP :..::::::::::::.:..:::::::::.:: :.::. . ::::::::::: : CCDS13 AISKLGPGEKYELHAATDTTPSVVVHVCESDQEKEEEEEMERMRRPKPKIIQTRRPEYTP 190 200 210 220 230 240 240 pF1KE0 SVSN CCDS13 IHLS 250 >>CCDS33551.1 RCAN1 gene_id:1827|Hs108|chr21 (197 aa) initn: 437 init1: 437 opt: 805 Z-score: 824.3 bits: 159.6 E(32554): 1.4e-39 Smith-Waterman score: 805; 62.7% identity (81.9% similar) in 193 aa overlap (51-239:5-193) 30 40 50 60 70 80 pF1KE0 EDGGLFLLCCIDRDWAVTRCFAEEAFQAITDFNDLPNSLFACNVHQSVFEGEESKEKFEG .:: .::.:: .....: :.. :::. CCDS33 MHFRNFNYSFSSLIACVANSDIFSESETRAKFES 10 20 30 90 100 110 120 130 140 pF1KE0 LFRTYDDCVTFQLFKSFRRVRINFSNPKSAARARIELHETQFRGKKLKLYFAQVQTPETD :::::: .::: ::::.::::::::: ::: ::..::.:.: ::..::::::. .. CCDS33 LFRTYDKDITFQYFKSFKRVRINFSNPFSAADARLQLHKTEFLGKEMKLYFAQTLHIGSS 40 50 60 70 80 90 150 160 170 180 190 200 pF1KE0 GDKLHLAPPQPAKQFLISPPSSPPVGWQPINDATPVLNYDLLYAVAKLGPGEKYELHAGT :::::.: ::::::::.::::::. ..:::::.:::::::..::::::::::::.: CCDS33 ----HLAPPNPDKQFLISPPASPPVGWKQVEDATPVINYDLLYAISKLGPGEKYELHAAT 100 110 120 130 140 150 210 220 230 240 pF1KE0 ESTPSVVVHVCDSDIEEEEDPKTS----PKPKIIQTRRPGLPPSVSN ..:::::::::.:: :.::. . ::::::::::: : CCDS33 DTTPSVVVHVCESDQEKEEEEEMERMRRPKPKIIQTRRPEYTPIHLS 160 170 180 190 >>CCDS74788.1 RCAN1 gene_id:1827|Hs108|chr21 (277 aa) initn: 454 init1: 437 opt: 764 Z-score: 780.7 bits: 152.1 E(32554): 3.7e-37 Smith-Waterman score: 764; 67.6% identity (83.5% similar) in 170 aa overlap (74-239:108-273) 50 60 70 80 90 100 pF1KE0 EAFQAITDFNDLPNSLFACNVHQSVFEGEESKEKFEGLFRTYDDCVTFQLFKSFRRVRIN :: :::.:::::: .::: ::::.::::: CCDS74 LLAVNIPEDTLLSYPESSLPLQRHCAFHRFSKAKFESLFRTYDKDITFQYFKSFKRVRIN 80 90 100 110 120 130 110 120 130 140 150 160 pF1KE0 FSNPKSAARARIELHETQFRGKKLKLYFAQVQTPETDGDKLHLAPPQPAKQFLISPPSSP :::: ::: ::..::.:.: ::..::::::. .. :::::.: ::::::::.:: CCDS74 FSNPFSAADARLQLHKTEFLGKEMKLYFAQTLHIGSS----HLAPPNPDKQFLISPPASP 140 150 160 170 180 190 170 180 190 200 210 220 pF1KE0 PVGWQPINDATPVLNYDLLYAVAKLGPGEKYELHAGTESTPSVVVHVCDSDIEEEEDPKT ::::. ..:::::.:::::::..::::::::::::.:..:::::::::.:: :.::. . CCDS74 PVGWKQVEDATPVINYDLLYAISKLGPGEKYELHAATDTTPSVVVHVCESDQEKEEEEEM 200 210 220 230 240 250 230 240 pF1KE0 S----PKPKIIQTRRPGLPPSVSN ::::::::::: : CCDS74 ERMRRPKPKIIQTRRPEYTPIHLS 260 270 >>CCDS74790.1 RCAN1 gene_id:1827|Hs108|chr21 (171 aa) initn: 437 init1: 437 opt: 754 Z-score: 773.7 bits: 150.1 E(32554): 8.9e-37 Smith-Waterman score: 754; 67.7% identity (83.8% similar) in 167 aa overlap (77-239:5-167) 50 60 70 80 90 100 pF1KE0 QAITDFNDLPNSLFACNVHQSVFEGEESKEKFEGLFRTYDDCVTFQLFKSFRRVRINFSN :::.:::::: .::: ::::.:::::::: CCDS74 MVYAKFESLFRTYDKDITFQYFKSFKRVRINFSN 10 20 30 110 120 130 140 150 160 pF1KE0 PKSAARARIELHETQFRGKKLKLYFAQVQTPETDGDKLHLAPPQPAKQFLISPPSSPPVG : ::: ::..::.:.: ::..::::::. .. :::::.: ::::::::.::::: CCDS74 PFSAADARLQLHKTEFLGKEMKLYFAQTLHIGSS----HLAPPNPDKQFLISPPASPPVG 40 50 60 70 80 90 170 180 190 200 210 220 pF1KE0 WQPINDATPVLNYDLLYAVAKLGPGEKYELHAGTESTPSVVVHVCDSDIEEEEDPKTS-- :. ..:::::.:::::::..::::::::::::.:..:::::::::.:: :.::. . CCDS74 WKQVEDATPVINYDLLYAISKLGPGEKYELHAATDTTPSVVVHVCESDQEKEEEEEMERM 100 110 120 130 140 150 230 240 pF1KE0 --PKPKIIQTRRPGLPPSVSN ::::::::::: : CCDS74 RRPKPKIIQTRRPEYTPIHLS 160 170 >>CCDS82668.1 RCAN1 gene_id:1827|Hs108|chr21 (205 aa) initn: 611 init1: 331 opt: 619 Z-score: 636.3 bits: 124.9 E(32554): 4e-29 Smith-Waterman score: 619; 53.1% identity (78.0% similar) in 177 aa overlap (51-227:5-174) 30 40 50 60 70 80 pF1KE0 EDGGLFLLCCIDRDWAVTRCFAEEAFQAITDFNDLPNSLFACNVHQSVFEGEESKEKFEG .:: .::.:: .....: :.. :::. CCDS82 MHFRNFNYSFSSLIACVANSDIFSESETRAKFES 10 20 30 90 100 110 120 130 140 pF1KE0 LFRTYDDCVTFQLFKSFRRVRINFSNPKSAARARIELHETQFRGKKLKLYFAQVQTPETD :::::: .::: ::::.::::::::: ::: ::..::.:.: ::..::::::. .. CCDS82 LFRTYDKDITFQYFKSFKRVRINFSNPFSAADARLQLHKTEFLGKEMKLYFAQTLHIGSS 40 50 60 70 80 90 150 160 170 180 190 200 pF1KE0 GDKLHLAPPQPAKQFLISPPSSPPVGWQPINDATPVLNYDLLYAVAKLGPGEKYELHAGT :::::.: ::::::::.::::::. ..:::::.:::::::..::::::. .: CCDS82 ----HLAPPNPDKQFLISPPASPPVGWKQVEDATPVINYDLLYAISKLGPGEQGPRVGGR 100 110 120 130 140 150 210 220 230 240 pF1KE0 ESTPSVVVHVCDSDIEEEEDPKTSPKPKIIQTRRPGLPPSVSN .. ... : . . .. :..::.: CCDS82 QGETQLL--PCTRE-QYHHYPRSSPEPMPACFVSFSVFFCATVPCAGSMPASWHHLQC 160 170 180 190 200 >>CCDS42921.1 RCAN1 gene_id:1827|Hs108|chr21 (117 aa) initn: 452 init1: 437 opt: 516 Z-score: 536.0 bits: 105.6 E(32554): 1.6e-23 Smith-Waterman score: 516; 65.8% identity (82.1% similar) in 117 aa overlap (127-239:1-113) 100 110 120 130 140 150 pF1KE0 FRRVRINFSNPKSAARARIELHETQFRGKKLKLYFAQVQTPETDGDKLHLAPPQPAKQFL .::::::. .. :::::.: :::: CCDS42 MKLYFAQTLHIGSS----HLAPPNPDKQFL 10 20 160 170 180 190 200 210 pF1KE0 ISPPSSPPVGWQPINDATPVLNYDLLYAVAKLGPGEKYELHAGTESTPSVVVHVCDSDIE ::::.::::::. ..:::::.:::::::..::::::::::::.:..:::::::::.:: : CCDS42 ISPPASPPVGWKQVEDATPVINYDLLYAISKLGPGEKYELHAATDTTPSVVVHVCESDQE 30 40 50 60 70 80 220 230 240 pF1KE0 EEEDPKTS----PKPKIIQTRRPGLPPSVSN .::. . ::::::::::: : CCDS42 KEEEEEMERMRRPKPKIIQTRRPEYTPIHLS 90 100 110 >>CCDS57981.1 RCAN3 gene_id:11123|Hs108|chr1 (183 aa) initn: 544 init1: 440 opt: 509 Z-score: 526.0 bits: 104.4 E(32554): 5.6e-23 Smith-Waterman score: 518; 44.7% identity (59.4% similar) in 217 aa overlap (28-242:16-172) 10 20 30 40 50 pF1KE0 MRGESYFIGMRSPGQQGHVPEDGGLFLLCCIDRDWAVTRCFAE--EAFQAITDFNDLPNS :: :.. :.: . .. . :..:::.: CCDS57 MLRDTMKSWNDSQSDLCSTDQEEEEEMIFGENEDDLDEMMDLSDLPTS 10 20 30 40 60 70 80 90 100 110 pF1KE0 LFACNVHQSVFEGEESKEKFEGLFRTYDDCVTFQLFKSFRRVRINFSNPKSAARARIELH ::::.::..:::..:.: .. : : CCDS57 LFACSVHEAVFEAREQKVQMSGEVR----------------------------------- 50 60 70 120 130 140 150 160 170 pF1KE0 ETQFRGKKLKLYFAQVQTPETDGDKLHLAPPQPAKQFLISPPSSPPVGWQPINDATPVLN :: .: ::::.::::::::.::::::. .:: ::.: CCDS57 -----------------------DKSYLLPPQPVKQFLISPPASPPVGWKQSEDAMPVIN 80 90 100 110 180 190 200 210 220 230 pF1KE0 YDLLYAVAKLGPGEKYELHAGTESTPSVVVHVCDSDIEEEEDPKTSPKPKIIQTRRPGLP :::: ::.:::::::::::::::::::::::::.:. ::::. : .:: :: ::::: : CCDS57 YDLLCAVSKLGPGEKYELHAGTESTPSVVVHVCESETEEEEETK-NPKQKIAQTRRPD-P 120 130 140 150 160 240 pF1KE0 PSVSN :... CCDS57 PTAALNEPQTFDCAL 170 180 243 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Wed Nov 2 18:17:02 2016 done: Wed Nov 2 18:17:03 2016 Total Scan time: 2.420 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]