FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0668, 393 aa 1>>>pF1KE0668 393 - 393 aa - 393 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.9222+/-0.000471; mu= 1.6782+/- 0.029 mean_var=553.4146+/-124.471, 0's: 0 Z-trim(120.2): 1403 B-trim: 33 in 1/53 Lambda= 0.054519 statistics sampled from 33032 (35219) to 33032 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.765), E-opt: 0.2 (0.413), width: 16 Scan time: 9.680 The best scores are: opt bits E(85289) NP_002746 (OMIM: 163950,176872,615279) dual specif ( 393) 2625 221.5 2.8e-57 XP_011520085 (OMIM: 163950,176872,615279) PREDICTE ( 371) 2444 207.2 5.2e-53 NP_109587 (OMIM: 601263,615280) dual specificity m ( 400) 2130 182.6 1.5e-45 XP_016882478 (OMIM: 601263,615280) PREDICTED: dual ( 512) 1861 161.6 3.9e-39 XP_016877901 (OMIM: 163950,176872,615279) PREDICTE ( 345) 1510 133.7 6.6e-31 XP_016877900 (OMIM: 163950,176872,615279) PREDICTE ( 367) 1510 133.7 6.8e-31 XP_016877902 (OMIM: 163950,176872,615279) PREDICTE ( 217) 1390 123.9 3.6e-28 XP_016882480 (OMIM: 601263,615280) PREDICTED: dual ( 252) 1270 114.6 2.7e-25 XP_006722862 (OMIM: 601263,615280) PREDICTED: dual ( 307) 1268 114.6 3.3e-25 XP_016882479 (OMIM: 601263,615280) PREDICTED: dual ( 419) 1270 115.0 3.5e-25 NP_001193733 (OMIM: 602520) dual specificity mitog ( 412) 808 78.6 3e-14 NP_660143 (OMIM: 602520) dual specificity mitogen- ( 448) 808 78.7 3.1e-14 NP_002748 (OMIM: 602520) dual specificity mitogen- ( 438) 761 75.0 4e-13 NP_002749 (OMIM: 601254) dual specificity mitogen- ( 334) 636 64.9 3.2e-10 XP_011523328 (OMIM: 601254) PREDICTED: dual specif ( 337) 636 64.9 3.2e-10 XP_011523327 (OMIM: 601254) PREDICTED: dual specif ( 345) 636 64.9 3.2e-10 NP_003001 (OMIM: 601335) dual specificity mitogen- ( 399) 612 63.2 1.3e-09 NP_001268364 (OMIM: 601335) dual specificity mitog ( 410) 612 63.2 1.3e-09 XP_005256780 (OMIM: 602315) PREDICTED: dual specif ( 318) 608 62.7 1.4e-09 NP_002747 (OMIM: 602315) dual specificity mitogen- ( 318) 608 62.7 1.4e-09 XP_016880348 (OMIM: 602315) PREDICTED: dual specif ( 318) 608 62.7 1.4e-09 XP_011522261 (OMIM: 602315) PREDICTED: dual specif ( 318) 608 62.7 1.4e-09 NP_001303261 (OMIM: 602315) dual specificity mitog ( 318) 608 62.7 1.4e-09 XP_016880347 (OMIM: 602315) PREDICTED: dual specif ( 318) 608 62.7 1.4e-09 XP_016880346 (OMIM: 602315) PREDICTED: dual specif ( 343) 608 62.7 1.5e-09 NP_659731 (OMIM: 602315) dual specificity mitogen- ( 347) 608 62.8 1.5e-09 XP_011522260 (OMIM: 602315) PREDICTED: dual specif ( 298) 601 62.1 2e-09 XP_005257573 (OMIM: 601254) PREDICTED: dual specif ( 278) 600 62.0 2.1e-09 XP_006722038 (OMIM: 601254) PREDICTED: dual specif ( 278) 600 62.0 2.1e-09 NP_001317379 (OMIM: 601254) dual specificity mitog ( 278) 600 62.0 2.1e-09 XP_011523329 (OMIM: 601254) PREDICTED: dual specif ( 278) 600 62.0 2.1e-09 NP_660186 (OMIM: 603014) dual specificity mitogen- ( 419) 590 61.5 4.4e-09 NP_001284484 (OMIM: 603014) dual specificity mitog ( 435) 590 61.5 4.5e-09 XP_005256810 (OMIM: 601335) PREDICTED: dual specif ( 281) 569 59.5 1.1e-08 XP_011522278 (OMIM: 601335) PREDICTED: dual specif ( 319) 567 59.5 1.3e-08 NP_001284485 (OMIM: 603014) dual specificity mitog ( 426) 556 58.8 2.8e-08 XP_006722863 (OMIM: 603014) PREDICTED: dual specif ( 442) 556 58.8 2.9e-08 XP_005256812 (OMIM: 601335) PREDICTED: dual specif ( 253) 513 55.0 2.3e-07 XP_011522279 (OMIM: 601335) PREDICTED: dual specif ( 253) 513 55.0 2.3e-07 XP_016883522 (OMIM: 604965,614868) PREDICTED: seri ( 388) 510 55.1 3.3e-07 XP_005260590 (OMIM: 604965,614868) PREDICTED: seri ( 462) 510 55.3 3.6e-07 NP_006273 (OMIM: 604965,614868) serine/threonine-p ( 487) 510 55.3 3.7e-07 XP_016869247 (OMIM: 605030) PREDICTED: serine/thre ( 456) 509 55.2 3.8e-07 NP_001243241 (OMIM: 605030) serine/threonine-prote ( 519) 510 55.3 3.8e-07 XP_016869246 (OMIM: 605030) PREDICTED: serine/thre ( 524) 510 55.3 3.8e-07 NP_006272 (OMIM: 605030) serine/threonine-protein ( 491) 509 55.2 3.9e-07 XP_016869250 (OMIM: 605030) PREDICTED: serine/thre ( 403) 507 54.9 4e-07 XP_011515550 (OMIM: 605030) PREDICTED: serine/thre ( 576) 510 55.4 4e-07 XP_016869245 (OMIM: 605030) PREDICTED: serine/thre ( 580) 510 55.4 4e-07 XP_011515553 (OMIM: 605030) PREDICTED: serine/thre ( 522) 509 55.3 4e-07 >>NP_002746 (OMIM: 163950,176872,615279) dual specificit (393 aa) initn: 2625 init1: 2625 opt: 2625 Z-score: 1149.4 bits: 221.5 E(85289): 2.8e-57 Smith-Waterman score: 2625; 100.0% identity (100.0% similar) in 393 aa overlap (1-393:1-393) 10 20 30 40 50 60 pF1KE0 MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF 310 320 330 340 350 360 370 380 390 pF1KE0 IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV ::::::::::::::::::::::::::::::::: NP_002 IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV 370 380 390 >>XP_011520085 (OMIM: 163950,176872,615279) PREDICTED: d (371 aa) initn: 2444 init1: 2444 opt: 2444 Z-score: 1072.6 bits: 207.2 E(85289): 5.2e-53 Smith-Waterman score: 2444; 100.0% identity (100.0% similar) in 366 aa overlap (28-393:6-371) 10 20 30 40 50 60 pF1KE0 MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV ::::::::::::::::::::::::::::::::: XP_011 MKLERTNLEALQKKLEELELDEQQRKRLEAFLTQKQKV 10 20 30 70 80 90 100 110 120 pF1KE0 GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE0 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE0 REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE0 SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY 220 230 240 250 260 270 310 320 330 340 350 360 pF1KE0 GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF 280 290 300 310 320 330 370 380 390 pF1KE0 IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV ::::::::::::::::::::::::::::::::: XP_011 IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV 340 350 360 370 >>NP_109587 (OMIM: 601263,615280) dual specificity mitog (400 aa) initn: 2120 init1: 1539 opt: 2130 Z-score: 938.9 bits: 182.6 E(85289): 1.5e-45 Smith-Waterman score: 2130; 80.4% identity (92.0% similar) in 398 aa overlap (1-391:2-399) 10 20 30 40 50 pF1KE0 MPKKKPT-P-IQLNPA-PDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQ . ..::. : . .::. .: . .. ...:.:: ::::::::::::::.::::::::: NP_109 MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQ 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE0 KQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQ : :::::::::::.:::::::::::: ::.:.::::.::::::::::::::::::::::: NP_109 KAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQ 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE0 VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKG ::::::::::::::::::::::::::::::::::::::::.: ::::.:::::::::..: NP_109 VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE0 LTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQ :.::::::.:::::::::::::::::::::::::::::::::::::::::::::.::::: NP_109 LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQ 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE0 GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQV----EGDAAETPPRPRT :::::::::::::::::::.:::::::::::::::: .:: : ::. :::: NP_109 GTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRP 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE0 PGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADL ::::.:..:::::: :::::::::::::::::::.:::. .::.:::::::::::::::: NP_109 PGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADL 310 320 330 340 350 360 360 370 380 390 pF1KE0 KQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV :.: :.:::::..::::::::::.:. ::::.:::..: NP_109 KMLTNHTFIKRSEVEEVDFAGWLCKTLRLNQPGTPTRTAV 370 380 390 400 >>XP_016882478 (OMIM: 601263,615280) PREDICTED: dual spe (512 aa) initn: 1539 init1: 1539 opt: 1861 Z-score: 823.6 bits: 161.6 E(85289): 3.9e-39 Smith-Waterman score: 1861; 81.0% identity (91.6% similar) in 347 aa overlap (1-340:2-348) 10 20 30 40 50 pF1KE0 MPKKKPT-P-IQLNPA-PDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQ . ..::. : . .::. .: . .. ...:.:: ::::::::::::::.::::::::: XP_016 MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQ 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE0 KQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQ : :::::::::::.:::::::::::: ::.:.::::.::::::::::::::::::::::: XP_016 KAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQ 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE0 VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKG ::::::::::::::::::::::::::::::::::::::::.: ::::.:::::::::..: XP_016 VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE0 LTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQ :.::::::.:::::::::::::::::::::::::::::::::::::::::::::.::::: XP_016 LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQ 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE0 GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQV----EGDAAETPPRPRT :::::::::::::::::::.:::::::::::::::: .:: : ::. :::: XP_016 GTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRP 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE0 PGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADL ::::.:..:::::: :::::::::::::::::::.:::. .::.:::: XP_016 PGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKWFWEGRQPHSIL 310 320 330 340 350 360 360 370 380 390 pF1KE0 KQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV XP_016 LPPSTQQHLWRGLHRHVPQTTGKELRTPRCPQGRSMCVSSGRRGTAPHSWCRSCPGPLAC 370 380 390 400 410 420 >>XP_016877901 (OMIM: 163950,176872,615279) PREDICTED: d (345 aa) initn: 2267 init1: 1506 opt: 1510 Z-score: 675.9 bits: 133.7 E(85289): 6.6e-31 Smith-Waterman score: 2219; 92.9% identity (92.9% similar) in 366 aa overlap (28-393:6-345) 10 20 30 40 50 60 pF1KE0 MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV ::::::::::::::::::::::::::::::::: XP_016 MKLERTNLEALQKKLEELELDEQQRKRLEAFLTQKQKV 10 20 30 70 80 90 100 110 120 pF1KE0 GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE0 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL :::::::::::::::::::::::::: :::::::: XP_016 CNSPYIVGFYGAFYSDGEISICMEHM--------------------------VIKGLTYL 100 110 120 130 190 200 210 220 230 240 pF1KE0 REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY 140 150 160 170 180 190 250 260 270 280 290 300 pF1KE0 SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY 200 210 220 230 240 250 310 320 330 340 350 360 pF1KE0 GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF 260 270 280 290 300 310 370 380 390 pF1KE0 IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV ::::::::::::::::::::::::::::::::: XP_016 IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV 320 330 340 >>XP_016877900 (OMIM: 163950,176872,615279) PREDICTED: d (367 aa) initn: 2448 init1: 1506 opt: 1510 Z-score: 675.7 bits: 133.7 E(85289): 6.8e-31 Smith-Waterman score: 2400; 93.4% identity (93.4% similar) in 393 aa overlap (1-393:1-367) 10 20 30 40 50 60 pF1KE0 MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL :::::::::::::::::::::::::: :::::::: XP_016 CNSPYIVGFYGAFYSDGEISICMEHM--------------------------VIKGLTYL 130 140 150 190 200 210 220 230 240 pF1KE0 REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE0 SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY 220 230 240 250 260 270 310 320 330 340 350 360 pF1KE0 GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF 280 290 300 310 320 330 370 380 390 pF1KE0 IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV ::::::::::::::::::::::::::::::::: XP_016 IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV 340 350 360 >>XP_016877902 (OMIM: 163950,176872,615279) PREDICTED: d (217 aa) initn: 1390 init1: 1390 opt: 1390 Z-score: 626.6 bits: 123.9 E(85289): 3.6e-28 Smith-Waterman score: 1390; 98.5% identity (100.0% similar) in 206 aa overlap (188-393:12-217) 160 170 180 190 200 210 pF1KE0 AGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID ...::::::::::::::::::::::::::: XP_016 MVPVHQQFLSKQHNVKPSNILVNSRGEIKLCDFGVSGQLID 10 20 30 40 220 230 240 250 260 270 pF1KE0 SMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGC 50 60 70 80 90 100 280 290 300 310 320 330 pF1KE0 QVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDF 110 120 130 140 150 160 340 350 360 370 380 390 pF1KE0 VNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV 170 180 190 200 210 >>XP_016882480 (OMIM: 601263,615280) PREDICTED: dual spe (252 aa) initn: 1227 init1: 1227 opt: 1270 Z-score: 575.1 bits: 114.6 E(85289): 2.7e-25 Smith-Waterman score: 1270; 78.5% identity (90.4% similar) in 251 aa overlap (1-248:2-250) 10 20 30 40 50 pF1KE0 MPKKKPT-P-IQLNPA-PDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQ . ..::. : . .::. .: . .. ...:.:: ::::::::::::::.::::::::: XP_016 MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQ 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE0 KQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQ : :::::::::::.:::::::::::: ::.:.::::.::::::::::::::::::::::: XP_016 KAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQ 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE0 VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKG ::::::::::::::::::::::::::::::::::::::::.: ::::.:::::::::..: XP_016 VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE0 LTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQ :.::::::.:::::::::::::::::::::::::::::::::::::::::::::. . XP_016 LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMA--ETT 190 200 210 220 230 240 250 260 270 280 290 pF1KE0 GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRP : . : . :: XP_016 GDSATCQIEPWSSL 240 250 >>XP_006722862 (OMIM: 601263,615280) PREDICTED: dual spe (307 aa) initn: 1608 init1: 1237 opt: 1268 Z-score: 573.5 bits: 114.6 E(85289): 3.3e-25 Smith-Waterman score: 1455; 62.7% identity (72.8% similar) in 394 aa overlap (1-391:2-306) 10 20 30 40 50 pF1KE0 MPKKKPT-P-IQLNPA-PDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQ . ..::. : . .::. .: . .. ...:.:: ::::::::::::::.::::::::: XP_006 MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQ 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE0 KQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQ : :::::::::::.:::::::::::: ::.:.::::.::::::::::::::::::::::: XP_006 KAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQ 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE0 VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKG ::::::::::::::::::::::::::::::::::::::::.: ::::.:::::::::..: XP_006 VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE0 LTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQ :.::::::.:::::::::::::::::::::::::::::::::::::::::::::.: XP_006 LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAP---- 190 200 210 220 230 240 250 260 270 280 290 pF1KE0 GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRP XP_006 ------------------------------------------------------------ 300 310 320 330 340 350 pF1KE0 LSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLM :::::.:::. .::.:::::::::::::::::.: XP_006 -------------------------PPKLPNGVFTPDFQEFVNKCLIKNPAERADLKMLT 240 250 260 270 360 370 380 390 pF1KE0 VHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV :.:::::..::::::::::.:. ::::.:::..: XP_006 NHTFIKRSEVEEVDFAGWLCKTLRLNQPGTPTRTAV 280 290 300 >>XP_016882479 (OMIM: 601263,615280) PREDICTED: dual spe (419 aa) initn: 1273 init1: 1251 opt: 1270 Z-score: 573.1 bits: 115.0 E(85289): 3.5e-25 Smith-Waterman score: 1270; 62.9% identity (76.6% similar) in 342 aa overlap (1-326:2-333) 10 20 30 40 50 pF1KE0 MPKKKPT-P-IQLNPA-PDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQ . ..::. : . .::. .: . .. ...:.:: ::::::::::::::.::::::::: XP_016 MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQ 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE0 KQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQ : :::::::::::.:::::::::::: ::.:.::::.::::::::::::::::::::::: XP_016 KAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQ 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE0 VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKG ::::::::::::::::::::::::::::::::::::::::.: ::::.:::::::::..: XP_016 VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE0 LTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPE-RL :.::::::.:::::::::::::::::::::::::::::::::::::::::::::.: .: XP_016 LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPPPKL 190 200 210 220 230 240 240 250 260 270 280 pF1KE0 QGTHYS------VQSDIWSMGLSLVEMAVGRYP----IPPPDAKELELMFGCQVEGDAAE . .. :.. .: :: : .:: ..: . .: ... XP_016 PNGVFTPDFQEFVNKWFWE----------GRQPHSILLPPSTQQHLWRGLHRHVPQTTGK 250 260 270 280 290 290 300 310 320 330 340 pF1KE0 TPPRPRTP-GRPLS-SYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLI :: : :: . : : . : . . . : :: XP_016 ELRTPRCPQGRSMCVSSGRRGTAPHSWCRSCPGPLACAPAMLPRAWGFIRQLAGVASRLL 300 310 320 330 340 350 350 360 370 380 390 pF1KE0 KNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV XP_016 THQAGFPTLFPSHPPAGGCPAPGTKVQRWIPRPLPGGRTEQPLCATLSGRRDPGPLRPRP 360 370 380 390 400 410 393 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Wed Nov 2 18:11:26 2016 done: Wed Nov 2 18:11:28 2016 Total Scan time: 9.680 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]