FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0669, 249 aa 1>>>pF1KE0669 249 - 249 aa - 249 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 11.4970+/-0.000366; mu= -11.3638+/- 0.023 mean_var=424.0495+/-85.886, 0's: 0 Z-trim(125.5): 17 B-trim: 0 in 0/62 Lambda= 0.062282 statistics sampled from 49470 (49487) to 49470 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.836), E-opt: 0.2 (0.58), width: 16 Scan time: 7.210 The best scores are: opt bits E(85289) XP_006719320 (OMIM: 614239) PREDICTED: sesquipedal ( 249) 1724 167.8 1.7e-41 NP_653272 (OMIM: 614239) sesquipedalian-1 isoform ( 249) 1724 167.8 1.7e-41 NP_001171468 (OMIM: 614239) sesquipedalian-1 isofo ( 249) 1724 167.8 1.7e-41 XP_011536278 (OMIM: 614239) PREDICTED: sesquipedal ( 249) 1724 167.8 1.7e-41 XP_016874372 (OMIM: 614239) PREDICTED: sesquipedal ( 249) 1724 167.8 1.7e-41 NP_001171467 (OMIM: 614239) sesquipedalian-1 isofo ( 262) 1724 167.8 1.7e-41 XP_005261430 (OMIM: 614240) PREDICTED: sesquipedal ( 259) 482 56.2 6.7e-08 NP_001002034 (OMIM: 614240) sesquipedalian-2 [Homo ( 259) 482 56.2 6.7e-08 >>XP_006719320 (OMIM: 614239) PREDICTED: sesquipedalian- (249 aa) initn: 1724 init1: 1724 opt: 1724 Z-score: 866.2 bits: 167.8 E(85289): 1.7e-41 Smith-Waterman score: 1724; 100.0% identity (100.0% similar) in 249 aa overlap (1-249:1-249) 10 20 30 40 50 60 pF1KE0 MKLNERSLAFYATCDAPVDNAGFLYKKGGRHAAYHRRWFVLRGNMLFYFEDAASREPVGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MKLNERSLAFYATCDAPVDNAGFLYKKGGRHAAYHRRWFVLRGNMLFYFEDAASREPVGV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 IILEGCTVELVEAAEEFAFAVRFAGTRARTYVLAAESQDAMEGWVKALSRASFDYLRLVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 IILEGCTVELVEAAEEFAFAVRFAGTRARTYVLAAESQDAMEGWVKALSRASFDYLRLVV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 RELEQQLAAVRGGGGMALPQPQPQSLPLPPSLPSALAPVPSLPSAPAPVPALPLPRRPSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RELEQQLAAVRGGGGMALPQPQPQSLPLPPSLPSALAPVPSLPSAPAPVPALPLPRRPSA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 LPPKENGCAVWSTEATFRPGPEPPPPPPRRRASAPHGPLDMAPFARLHECYGQEIRALRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LPPKENGCAVWSTEATFRPGPEPPPPPPRRRASAPHGPLDMAPFARLHECYGQEIRALRG 190 200 210 220 230 240 pF1KE0 QWLSSRVQP ::::::::: XP_006 QWLSSRVQP >>NP_653272 (OMIM: 614239) sesquipedalian-1 isoform 2 [H (249 aa) initn: 1724 init1: 1724 opt: 1724 Z-score: 866.2 bits: 167.8 E(85289): 1.7e-41 Smith-Waterman score: 1724; 100.0% identity (100.0% similar) in 249 aa overlap (1-249:1-249) 10 20 30 40 50 60 pF1KE0 MKLNERSLAFYATCDAPVDNAGFLYKKGGRHAAYHRRWFVLRGNMLFYFEDAASREPVGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_653 MKLNERSLAFYATCDAPVDNAGFLYKKGGRHAAYHRRWFVLRGNMLFYFEDAASREPVGV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 IILEGCTVELVEAAEEFAFAVRFAGTRARTYVLAAESQDAMEGWVKALSRASFDYLRLVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_653 IILEGCTVELVEAAEEFAFAVRFAGTRARTYVLAAESQDAMEGWVKALSRASFDYLRLVV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 RELEQQLAAVRGGGGMALPQPQPQSLPLPPSLPSALAPVPSLPSAPAPVPALPLPRRPSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_653 RELEQQLAAVRGGGGMALPQPQPQSLPLPPSLPSALAPVPSLPSAPAPVPALPLPRRPSA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 LPPKENGCAVWSTEATFRPGPEPPPPPPRRRASAPHGPLDMAPFARLHECYGQEIRALRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_653 LPPKENGCAVWSTEATFRPGPEPPPPPPRRRASAPHGPLDMAPFARLHECYGQEIRALRG 190 200 210 220 230 240 pF1KE0 QWLSSRVQP ::::::::: NP_653 QWLSSRVQP >>NP_001171468 (OMIM: 614239) sesquipedalian-1 isoform 2 (249 aa) initn: 1724 init1: 1724 opt: 1724 Z-score: 866.2 bits: 167.8 E(85289): 1.7e-41 Smith-Waterman score: 1724; 100.0% identity (100.0% similar) in 249 aa overlap (1-249:1-249) 10 20 30 40 50 60 pF1KE0 MKLNERSLAFYATCDAPVDNAGFLYKKGGRHAAYHRRWFVLRGNMLFYFEDAASREPVGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MKLNERSLAFYATCDAPVDNAGFLYKKGGRHAAYHRRWFVLRGNMLFYFEDAASREPVGV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 IILEGCTVELVEAAEEFAFAVRFAGTRARTYVLAAESQDAMEGWVKALSRASFDYLRLVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IILEGCTVELVEAAEEFAFAVRFAGTRARTYVLAAESQDAMEGWVKALSRASFDYLRLVV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 RELEQQLAAVRGGGGMALPQPQPQSLPLPPSLPSALAPVPSLPSAPAPVPALPLPRRPSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RELEQQLAAVRGGGGMALPQPQPQSLPLPPSLPSALAPVPSLPSAPAPVPALPLPRRPSA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 LPPKENGCAVWSTEATFRPGPEPPPPPPRRRASAPHGPLDMAPFARLHECYGQEIRALRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPPKENGCAVWSTEATFRPGPEPPPPPPRRRASAPHGPLDMAPFARLHECYGQEIRALRG 190 200 210 220 230 240 pF1KE0 QWLSSRVQP ::::::::: NP_001 QWLSSRVQP >>XP_011536278 (OMIM: 614239) PREDICTED: sesquipedalian- (249 aa) initn: 1724 init1: 1724 opt: 1724 Z-score: 866.2 bits: 167.8 E(85289): 1.7e-41 Smith-Waterman score: 1724; 100.0% identity (100.0% similar) in 249 aa overlap (1-249:1-249) 10 20 30 40 50 60 pF1KE0 MKLNERSLAFYATCDAPVDNAGFLYKKGGRHAAYHRRWFVLRGNMLFYFEDAASREPVGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MKLNERSLAFYATCDAPVDNAGFLYKKGGRHAAYHRRWFVLRGNMLFYFEDAASREPVGV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 IILEGCTVELVEAAEEFAFAVRFAGTRARTYVLAAESQDAMEGWVKALSRASFDYLRLVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IILEGCTVELVEAAEEFAFAVRFAGTRARTYVLAAESQDAMEGWVKALSRASFDYLRLVV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 RELEQQLAAVRGGGGMALPQPQPQSLPLPPSLPSALAPVPSLPSAPAPVPALPLPRRPSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RELEQQLAAVRGGGGMALPQPQPQSLPLPPSLPSALAPVPSLPSAPAPVPALPLPRRPSA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 LPPKENGCAVWSTEATFRPGPEPPPPPPRRRASAPHGPLDMAPFARLHECYGQEIRALRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LPPKENGCAVWSTEATFRPGPEPPPPPPRRRASAPHGPLDMAPFARLHECYGQEIRALRG 190 200 210 220 230 240 pF1KE0 QWLSSRVQP ::::::::: XP_011 QWLSSRVQP >>XP_016874372 (OMIM: 614239) PREDICTED: sesquipedalian- (249 aa) initn: 1724 init1: 1724 opt: 1724 Z-score: 866.2 bits: 167.8 E(85289): 1.7e-41 Smith-Waterman score: 1724; 100.0% identity (100.0% similar) in 249 aa overlap (1-249:1-249) 10 20 30 40 50 60 pF1KE0 MKLNERSLAFYATCDAPVDNAGFLYKKGGRHAAYHRRWFVLRGNMLFYFEDAASREPVGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MKLNERSLAFYATCDAPVDNAGFLYKKGGRHAAYHRRWFVLRGNMLFYFEDAASREPVGV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 IILEGCTVELVEAAEEFAFAVRFAGTRARTYVLAAESQDAMEGWVKALSRASFDYLRLVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IILEGCTVELVEAAEEFAFAVRFAGTRARTYVLAAESQDAMEGWVKALSRASFDYLRLVV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 RELEQQLAAVRGGGGMALPQPQPQSLPLPPSLPSALAPVPSLPSAPAPVPALPLPRRPSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RELEQQLAAVRGGGGMALPQPQPQSLPLPPSLPSALAPVPSLPSAPAPVPALPLPRRPSA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 LPPKENGCAVWSTEATFRPGPEPPPPPPRRRASAPHGPLDMAPFARLHECYGQEIRALRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LPPKENGCAVWSTEATFRPGPEPPPPPPRRRASAPHGPLDMAPFARLHECYGQEIRALRG 190 200 210 220 230 240 pF1KE0 QWLSSRVQP ::::::::: XP_016 QWLSSRVQP >>NP_001171467 (OMIM: 614239) sesquipedalian-1 isoform 1 (262 aa) initn: 1724 init1: 1724 opt: 1724 Z-score: 865.9 bits: 167.8 E(85289): 1.7e-41 Smith-Waterman score: 1724; 100.0% identity (100.0% similar) in 249 aa overlap (1-249:14-262) 10 20 30 40 pF1KE0 MKLNERSLAFYATCDAPVDNAGFLYKKGGRHAAYHRRWFVLRGNMLF ::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAPGSPPGPAIATMKLNERSLAFYATCDAPVDNAGFLYKKGGRHAAYHRRWFVLRGNMLF 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE0 YFEDAASREPVGVIILEGCTVELVEAAEEFAFAVRFAGTRARTYVLAAESQDAMEGWVKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YFEDAASREPVGVIILEGCTVELVEAAEEFAFAVRFAGTRARTYVLAAESQDAMEGWVKA 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE0 LSRASFDYLRLVVRELEQQLAAVRGGGGMALPQPQPQSLPLPPSLPSALAPVPSLPSAPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSRASFDYLRLVVRELEQQLAAVRGGGGMALPQPQPQSLPLPPSLPSALAPVPSLPSAPA 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE0 PVPALPLPRRPSALPPKENGCAVWSTEATFRPGPEPPPPPPRRRASAPHGPLDMAPFARL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PVPALPLPRRPSALPPKENGCAVWSTEATFRPGPEPPPPPPRRRASAPHGPLDMAPFARL 190 200 210 220 230 240 230 240 pF1KE0 HECYGQEIRALRGQWLSSRVQP :::::::::::::::::::::: NP_001 HECYGQEIRALRGQWLSSRVQP 250 260 >>XP_005261430 (OMIM: 614240) PREDICTED: sesquipedalian- (259 aa) initn: 522 init1: 211 opt: 482 Z-score: 262.8 bits: 56.2 E(85289): 6.7e-08 Smith-Waterman score: 484; 41.1% identity (61.2% similar) in 263 aa overlap (1-248:1-247) 10 20 30 40 50 pF1KE0 MKLNERSLAFYATCDAPVDNAGFLYKKGG-----RHAAYHRR-WFVLRGNMLFYFEDAAS :::::::.: :: :.:.:. ::: :: .. :: ::::.::.:: ::. . XP_005 MKLNERSVAHYALSDSPADHMGFLRTWGGPGTPPTPSGTGRRCWFVLKGNLLFSFESREG 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE0 REPVGVIILEGCTVELVEAA--EEFAFAVRFAGTRARTYVLAAESQDAMEGWVKALSRAS : :.....::::::::.:: ::::::. : . .: ..::::. :.:.:::.::::: XP_005 RAPLSLVVLEGCTVELAEAPVPEEFAFAICFDAPGVRPHLLAAEGPAAQEAWVKVLSRAS 70 80 90 100 110 120 120 130 140 150 160 pF1KE0 FDYLRLVVRELEQQLAAVRGGGGMALPQPQP-QSL-----PLPPSLPSA-LAPVPSLPSA : :.::::::::.:: .: . .:: . . .:. : :. .: : : . XP_005 FGYMRLVVRELESQLQDARQS--LALQRRSSWKSVASRCKPQAPNHRAAGLENGHCLSKD 130 140 150 160 170 170 180 190 200 210 220 pF1KE0 PAPVPALPLPRRPSALPPKENGCAVWSTEATFRPGPEPPPPPPRRRASAPHGPLDMAPFA .:: . :: : : : .. : ....: .: . . :. XP_005 SSPVGLVEEAGSRSA----GWGLAEWELQG--------PASLLLGKGQSPVSP-ETSCFS 180 190 200 210 220 230 240 pF1KE0 RLHECYGQEIRALRGQWLSSRVQP ::. ::::: :: : ..:.: XP_005 TLHDWYGQEIVELRQCW-QKRAQGSHSKCEEQDRP 230 240 250 >>NP_001002034 (OMIM: 614240) sesquipedalian-2 [Homo sap (259 aa) initn: 522 init1: 211 opt: 482 Z-score: 262.8 bits: 56.2 E(85289): 6.7e-08 Smith-Waterman score: 484; 41.1% identity (61.2% similar) in 263 aa overlap (1-248:1-247) 10 20 30 40 50 pF1KE0 MKLNERSLAFYATCDAPVDNAGFLYKKGG-----RHAAYHRR-WFVLRGNMLFYFEDAAS :::::::.: :: :.:.:. ::: :: .. :: ::::.::.:: ::. . NP_001 MKLNERSVAHYALSDSPADHMGFLRTWGGPGTPPTPSGTGRRCWFVLKGNLLFSFESREG 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE0 REPVGVIILEGCTVELVEAA--EEFAFAVRFAGTRARTYVLAAESQDAMEGWVKALSRAS : :.....::::::::.:: ::::::. : . .: ..::::. :.:.:::.::::: NP_001 RAPLSLVVLEGCTVELAEAPVPEEFAFAICFDAPGVRPHLLAAEGPAAQEAWVKVLSRAS 70 80 90 100 110 120 120 130 140 150 160 pF1KE0 FDYLRLVVRELEQQLAAVRGGGGMALPQPQP-QSL-----PLPPSLPSA-LAPVPSLPSA : :.::::::::.:: .: . .:: . . .:. : :. .: : : . NP_001 FGYMRLVVRELESQLQDARQS--LALQRRSSWKSVASRCKPQAPNHRAAGLENGHCLSKD 130 140 150 160 170 170 180 190 200 210 220 pF1KE0 PAPVPALPLPRRPSALPPKENGCAVWSTEATFRPGPEPPPPPPRRRASAPHGPLDMAPFA .:: . :: : : : .. : ....: .: . . :. NP_001 SSPVGLVEEAGSRSA----GWGLAEWELQG--------PASLLLGKGQSPVSP-ETSCFS 180 190 200 210 220 230 240 pF1KE0 RLHECYGQEIRALRGQWLSSRVQP ::. ::::: :: : ..:.: NP_001 TLHDWYGQEIVELRQCW-QKRAQGSHSKCEEQDRP 230 240 250 249 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Wed Nov 2 18:11:59 2016 done: Wed Nov 2 18:12:00 2016 Total Scan time: 7.210 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]