FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0673, 261 aa 1>>>pF1KE0673 261 - 261 aa - 261 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.2472+/-0.000436; mu= 4.5024+/- 0.028 mean_var=344.3430+/-72.509, 0's: 0 Z-trim(120.4): 180 B-trim: 1702 in 1/57 Lambda= 0.069116 statistics sampled from 35461 (35685) to 35461 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.757), E-opt: 0.2 (0.418), width: 16 Scan time: 7.540 The best scores are: opt bits E(85289) NP_473357 (OMIM: 605221) serine/arginine-rich spli ( 262) 834 96.3 6e-20 NP_001177934 (OMIM: 605221) serine/arginine-rich s ( 261) 828 95.7 9.1e-20 NP_001287866 (OMIM: 605221) serine/arginine-rich s ( 217) 766 89.4 6e-18 NP_006616 (OMIM: 605221) serine/arginine-rich spli ( 183) 734 86.1 4.9e-17 NP_001177935 (OMIM: 605221) serine/arginine-rich s ( 173) 729 85.6 6.8e-17 NP_001287865 (OMIM: 605221) serine/arginine-rich s ( 172) 723 85.0 1e-16 NP_001177936 (OMIM: 605221) serine/arginine-rich s ( 182) 722 84.9 1.1e-16 NP_001177938 (OMIM: 605221) serine/arginine-rich s ( 165) 710 83.6 2.4e-16 NP_003007 (OMIM: 600813) serine/arginine-rich spli ( 221) 445 57.4 2.6e-08 NP_001182356 (OMIM: 600813) serine/arginine-rich s ( 221) 445 57.4 2.6e-08 XP_016880431 (OMIM: 600813) PREDICTED: serine/argi ( 221) 445 57.4 2.6e-08 XP_005264541 (OMIM: 600572) PREDICTED: serine/argi ( 235) 399 52.8 6.5e-07 NP_001026854 (OMIM: 600572) serine/arginine-rich s ( 238) 390 52.0 1.2e-06 NP_001182375 (OMIM: 600572) serine/arginine-rich s ( 226) 388 51.7 1.4e-06 XP_005264542 (OMIM: 600572) PREDICTED: serine/argi ( 223) 380 50.9 2.3e-06 XP_016872631 (OMIM: 603269) PREDICTED: serine/argi ( 282) 376 50.7 3.5e-06 NP_115285 (OMIM: 603269) serine/arginine-rich spli ( 282) 376 50.7 3.5e-06 NP_003008 (OMIM: 603364) serine/arginine-rich spli ( 164) 333 46.0 5.1e-05 NP_006266 (OMIM: 601944) serine/arginine-rich spli ( 344) 303 43.5 0.00061 NP_008856 (OMIM: 600914) serine/arginine-rich spli ( 272) 265 39.6 0.0074 NP_001307143 (OMIM: 600914) serine/arginine-rich s ( 272) 265 39.6 0.0074 NP_001034554 (OMIM: 600914) serine/arginine-rich s ( 272) 265 39.6 0.0074 >>NP_473357 (OMIM: 605221) serine/arginine-rich splicing (262 aa) initn: 994 init1: 641 opt: 834 Z-score: 479.1 bits: 96.3 E(85289): 6e-20 Smith-Waterman score: 834; 56.6% identity (74.0% similar) in 265 aa overlap (1-261:1-254) 10 20 30 40 50 60 pF1KE0 MSRYTRPPNTSLFIRNVADATRPEDLRREFGRYGPIVDVYIPLDFYTRRPRGFAYVQFED :::: ::::::::.::::: :: :::::::::::::::::.::::::::::::::::::: NP_473 MSRYLRPPNTSLFVRNVADDTRSEDLRREFGRYGPIVDVYVPLDFYTRRPRGFAYVQFED 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 VRDAEDALYNLNRKWVCGRQIEIQFAQGDRKTPGQMKSKE-RHPCSPSDHRRSRSPSQRR ::::::::.::.:::.:::::::::::::::::.:::.:: :. : : : . :: NP_473 VRDAEDALHNLDRKWICGRQIEIQFAQGDRKTPNQMKAKEGRNVYSSS--RYDDYDRYRR 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 TRSRSSSWGRNRRRSDSLKESRHRRFSYSQSKSRSKSLPRRSTSARQSRTPRRNFGSRGR .:::: .:::: : . . . : ::: .:: . :::: : .: . : . .:. NP_473 SRSRS----YERRRSRSRSFDYNYRRSYSPRNSRPTGRPRRSRS--HSDNDRFKHRNRSF 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE0 SRSKSLQK-RSKSIGKSQSSSPQKQTS-SGTKSRSHGRHSDSIARSPCKSPKGYTNSETK ::::: .. :::: :.. .. ... : : ::.:. .. .:: .. :: . : . : NP_473 SRSKSNSRSRSKSQPKKEMKAKSRSRSASHTKTRGTSK-TDS--KTHYKSGSRYEKESRK 180 190 200 210 220 240 250 260 pF1KE0 VQTAK-HSHFRSHSRSRSYRHKNSW . . .:. ::.::::: .. :: NP_473 KEPPRSKSQSRSQSRSRSKSRSRSWTSPKSSGH 230 240 250 260 >>NP_001177934 (OMIM: 605221) serine/arginine-rich splic (261 aa) initn: 678 init1: 678 opt: 828 Z-score: 475.8 bits: 95.7 E(85289): 9.1e-20 Smith-Waterman score: 828; 55.1% identity (71.5% similar) in 267 aa overlap (1-260:1-258) 10 20 30 40 50 60 pF1KE0 MSRYTRPPNTSLFIRNVADATRPEDLRREFGRYGPIVDVYIPLDFYTRRPRGFAYVQFED :::: ::::::::.::::: :: :::::::::::::::::.::::::::::::::::::: NP_001 MSRYLRPPNTSLFVRNVADDTRSEDLRREFGRYGPIVDVYVPLDFYTRRPRGFAYVQFED 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 VRDAEDALYNLNRKWVCGRQIEIQFAQGDRKTPGQMKSKE-RHPCSPSDH------RRSR ::::::::.::.:::.:::::::::::::::::.:::.:: :. : : . :::: NP_001 VRDAEDALHNLDRKWICGRQIEIQFAQGDRKTPNQMKAKEGRNVYSSSRYDDYDRYRRSR 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE0 SPSQRRTRSRSSSWGRNRRRSDSLKESRHRRFSYSQSKSRSKSLPRRSTSARQSRTPRRN : : .: :::: :. : ::: : .. : :.:.: . . .:. : .:. NP_001 SRSYERRRSRSRSFDYNYRRSYSPRNRPTGRPRRSRSHSDNDRFKHRNRSFSRSK----- 130 140 150 160 170 180 190 200 210 220 230 pF1KE0 FGSRGRSRSKSLQKRSKSIGKSQSSSPQKQTSSGTKSRSHGRHSDSIARSPCKSPKGYTN : .:::::: : ... .::.: : .. . ::.. . : : .: .: : NP_001 --SNSRSRSKS-QPKKEMKAKSRSRSASHTKTRGTSKTDSKTHYKSGSRYEKESRKK-EP 180 190 200 210 220 230 240 250 260 pF1KE0 SETKVQTAKHSHFRSHSRSRSYRHKNSW ..: :. ..:. ::.:::::. .: NP_001 PRSKSQSRSQSRSRSKSRSRSWTSPKSSGH 240 250 260 >>NP_001287866 (OMIM: 605221) serine/arginine-rich splic (217 aa) initn: 955 init1: 641 opt: 766 Z-score: 443.3 bits: 89.4 E(85289): 6e-18 Smith-Waterman score: 781; 63.2% identity (77.4% similar) in 212 aa overlap (1-211:1-198) 10 20 30 40 50 60 pF1KE0 MSRYTRPPNTSLFIRNVADATRPEDLRREFGRYGPIVDVYIPLDFYTRRPRGFAYVQFED :::: ::::::::.::::: :: :::::::::::::::::.::::::::::::::::::: NP_001 MSRYLRPPNTSLFVRNVADDTRSEDLRREFGRYGPIVDVYVPLDFYTRRPRGFAYVQFED 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 VRDAEDALYNLNRKWVCGRQIEIQFAQGDRKTPGQMKSKE-RHPCSPSDHRRSRSPSQRR ::::::::.::.:::.:::::::::::::::::.:::.:: :. : : : . :: NP_001 VRDAEDALHNLDRKWICGRQIEIQFAQGDRKTPNQMKAKEGRNVYSSS--RYDDYDRYRR 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 TRSRSSSWGRNRRRSDSLKESRHRRFSYSQSKSRSKSLPRRSTSARQSRTPRRNFGSRGR .:::: .:::: : . . . : ::: .:: . :::: : .: . : . .:. NP_001 SRSRS----YERRRSRSRSFDYNYRRSYSPRNSRPTGRPRRSRS--HSDNDRFKHRNRSF 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE0 SRSKSLQKRSKSIGKSQSSSPQKQTSSGTKSRSHGRHSDSIARSPCKSPKGYTNSETKVQ ::::: ..::.: ::: :.:. .. ..:: NP_001 SRSKS-NSRSRS--KSQ---PKKEMKAKSRSRPNCSWNTQYSSAYYTSRKI 180 190 200 210 240 250 260 pF1KE0 TAKHSHFRSHSRSRSYRHKNSW >>NP_006616 (OMIM: 605221) serine/arginine-rich splicing (183 aa) initn: 849 init1: 641 opt: 734 Z-score: 426.8 bits: 86.1 E(85289): 4.9e-17 Smith-Waterman score: 734; 65.2% identity (77.9% similar) in 181 aa overlap (1-180:1-175) 10 20 30 40 50 60 pF1KE0 MSRYTRPPNTSLFIRNVADATRPEDLRREFGRYGPIVDVYIPLDFYTRRPRGFAYVQFED :::: ::::::::.::::: :: :::::::::::::::::.::::::::::::::::::: NP_006 MSRYLRPPNTSLFVRNVADDTRSEDLRREFGRYGPIVDVYVPLDFYTRRPRGFAYVQFED 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 VRDAEDALYNLNRKWVCGRQIEIQFAQGDRKTPGQMKSKE-RHPCSPSDHRRSRSPSQRR ::::::::.::.:::.:::::::::::::::::.:::.:: :. : : : . :: NP_006 VRDAEDALHNLDRKWICGRQIEIQFAQGDRKTPNQMKAKEGRNVYSSS--RYDDYDRYRR 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 TRSRSSSWGRNRRRSDSLKESRHRRFSYSQSKSRSKSLPRRSTSARQSRTPRRNFGSRGR .:::: .:::: : . . . : ::: .:: . :::: : .. : ..... NP_006 SRSRS----YERRRSRSRSFDYNYRRSYSPRNSRPTGRPRRSRSHSDNDRPNCSWNTQYS 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE0 SRSKSLQKRSKSIGKSQSSSPQKQTSSGTKSRSHGRHSDSIARSPCKSPKGYTNSETKVQ : NP_006 SAYYTSRKI 180 >>NP_001177935 (OMIM: 605221) serine/arginine-rich splic (173 aa) initn: 860 init1: 641 opt: 729 Z-score: 424.3 bits: 85.6 E(85289): 6.8e-17 Smith-Waterman score: 729; 68.2% identity (79.2% similar) in 173 aa overlap (1-165:1-173) 10 20 30 40 50 60 pF1KE0 MSRYTRPPNTSLFIRNVADATRPEDLRREFGRYGPIVDVYIPLDFYTRRPRGFAYVQFED :::: ::::::::.::::: :: :::::::::::::::::.::::::::::::::::::: NP_001 MSRYLRPPNTSLFVRNVADDTRSEDLRREFGRYGPIVDVYVPLDFYTRRPRGFAYVQFED 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 VRDAEDALYNLNRKWVCGRQIEIQFAQGDRKTPGQMKSKE-RHPCSPSDH------RRSR ::::::::.::.:::.:::::::::::::::::.:::.:: :. : : . :::: NP_001 VRDAEDALHNLDRKWICGRQIEIQFAQGDRKTPNQMKAKEGRNVYSSSRYDDYDRYRRSR 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE0 SPSQRRTRSRSSSWGRNRRRSDSLKESRHR-RFSYSQSKSRSKSLPRRSTSARQSRTPRR : : .: :::: :. : ::: : ..:: : :.:.: . : .. . : NP_001 SRSYERRRSRSRSFDYNYRRSYSPRNSRPTGRPRRSRSHSDNDSQVSKKKNER 130 140 150 160 170 180 190 200 210 220 230 pF1KE0 NFGSRGRSRSKSLQKRSKSIGKSQSSSPQKQTSSGTKSRSHGRHSDSIARSPCKSPKGYT >>NP_001287865 (OMIM: 605221) serine/arginine-rich splic (172 aa) initn: 873 init1: 641 opt: 723 Z-score: 421.1 bits: 85.0 E(85289): 1e-16 Smith-Waterman score: 723; 67.4% identity (78.5% similar) in 172 aa overlap (1-165:1-172) 10 20 30 40 50 60 pF1KE0 MSRYTRPPNTSLFIRNVADATRPEDLRREFGRYGPIVDVYIPLDFYTRRPRGFAYVQFED :::: ::::::::.::::: :: :::::::::::::::::.::::::::::::::::::: NP_001 MSRYLRPPNTSLFVRNVADDTRSEDLRREFGRYGPIVDVYVPLDFYTRRPRGFAYVQFED 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 VRDAEDALYNLNRKWVCGRQIEIQFAQGDRKTPGQMKSKE-RHPCSPSDH------RRSR ::::::::.::.:::.:::::::::::::::::.:::.:: :. : : . :::: NP_001 VRDAEDALHNLDRKWICGRQIEIQFAQGDRKTPNQMKAKEGRNVYSSSRYDDYDRYRRSR 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE0 SPSQRRTRSRSSSWGRNRRRSDSLKESRHRRFSYSQSKSRSKSLPRRSTSARQSRTPRRN : : .: :::: :. : ::: : .. : :.:.: . : .. . : NP_001 SRSYERRRSRSRSFDYNYRRSYSPRNRPTGRPRRSRSHSDNDSQVSKKKNER 130 140 150 160 170 180 190 200 210 220 230 pF1KE0 FGSRGRSRSKSLQKRSKSIGKSQSSSPQKQTSSGTKSRSHGRHSDSIARSPCKSPKGYTN >>NP_001177936 (OMIM: 605221) serine/arginine-rich splic (182 aa) initn: 790 init1: 641 opt: 722 Z-score: 420.3 bits: 84.9 E(85289): 1.1e-16 Smith-Waterman score: 722; 64.6% identity (77.9% similar) in 181 aa overlap (1-180:1-174) 10 20 30 40 50 60 pF1KE0 MSRYTRPPNTSLFIRNVADATRPEDLRREFGRYGPIVDVYIPLDFYTRRPRGFAYVQFED :::: ::::::::.::::: :: :::::::::::::::::.::::::::::::::::::: NP_001 MSRYLRPPNTSLFVRNVADDTRSEDLRREFGRYGPIVDVYVPLDFYTRRPRGFAYVQFED 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 VRDAEDALYNLNRKWVCGRQIEIQFAQGDRKTPGQMKSKE-RHPCSPSDHRRSRSPSQRR ::::::::.::.:::.:::::::::::::::::.:::.:: :. : : : . :: NP_001 VRDAEDALHNLDRKWICGRQIEIQFAQGDRKTPNQMKAKEGRNVYSSS--RYDDYDRYRR 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 TRSRSSSWGRNRRRSDSLKESRHRRFSYSQSKSRSKSLPRRSTSARQSRTPRRNFGSRGR .:::: .:::: : . . . : ::: ..: . :::: : .. : ..... NP_001 SRSRS----YERRRSRSRSFDYNYRRSYSP-RNRPTGRPRRSRSHSDNDRPNCSWNTQYS 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE0 SRSKSLQKRSKSIGKSQSSSPQKQTSSGTKSRSHGRHSDSIARSPCKSPKGYTNSETKVQ : NP_001 SAYYTSRKI 180 >>NP_001177938 (OMIM: 605221) serine/arginine-rich splic (165 aa) initn: 796 init1: 641 opt: 710 Z-score: 414.3 bits: 83.6 E(85289): 2.4e-16 Smith-Waterman score: 713; 69.9% identity (80.4% similar) in 163 aa overlap (1-153:1-163) 10 20 30 40 50 60 pF1KE0 MSRYTRPPNTSLFIRNVADATRPEDLRREFGRYGPIVDVYIPLDFYTRRPRGFAYVQFED :::: ::::::::.::::: :: :::::::::::::::::.::::::::::::::::::: NP_001 MSRYLRPPNTSLFVRNVADDTRSEDLRREFGRYGPIVDVYVPLDFYTRRPRGFAYVQFED 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 VRDAEDALYNLNRKWVCGRQIEIQFAQGDRKTPGQMKSKE-RHPCSPSDH------RRSR ::::::::.::.:::.:::::::::::::::::.:::.:: :. : : . :::: NP_001 VRDAEDALHNLDRKWICGRQIEIQFAQGDRKTPNQMKAKEGRNVYSSSRYDDYDRYRRSR 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE0 SPSQRRTRSRSSSWGRNRRRSDSLKE---SRHRRFSYSQSKSRSKSLPRRSTSARQSRTP : : .: :::: :. : ::: : .. : . ..: . :: NP_001 SRSYERRRSRSRSFDYNYRRSYSPRKPNCSWNTQYSSAYYTSRKI 130 140 150 160 180 190 200 210 220 230 pF1KE0 RRNFGSRGRSRSKSLQKRSKSIGKSQSSSPQKQTSSGTKSRSHGRHSDSIARSPCKSPKG >>NP_003007 (OMIM: 600813) serine/arginine-rich splicing (221 aa) initn: 646 init1: 285 opt: 445 Z-score: 270.2 bits: 57.4 E(85289): 2.6e-08 Smith-Waterman score: 459; 41.4% identity (63.7% similar) in 237 aa overlap (4-229:3-214) 10 20 30 40 50 pF1KE0 MSRYTRPPN-----TSLFIRNVADATRPEDLRREFGRYGPIVDVYIPLDFYTRRPRGFAY : ::: ::: . :.. : :. ::: : .:: . ::::: : ::.. ::::. NP_003 MSYGRPPPDVEGMTSLKVDNLTYRTSPDTLRRVFEKYGRVGDVYIPRDRYTKESRGFAF 10 20 30 40 50 60 70 80 90 100 pF1KE0 VQFEDVRDAEDALYNLNRKWVCGRQIEIQFAQGDRKTPGQMKSKERHPCSPSDH------ :.:.: ::::::. .. . ::....:.:. : : . .:.. : : . NP_003 VRFHDKRDAEDAMDAMDGAVLDGRELRVQMARYGRP-PDSHHSRRGPP--PRRYGGGGYG 60 70 80 90 100 110 110 120 130 140 150 160 pF1KE0 RRSRSPSQRRTRSRSSSWGRNRRRSDSLKESRHRRFSYSQSKSRSKSLPRRSTSARQSRT :::::: .:: :::: : .:.: :: : :.: :.:.::..: :: :. .::. NP_003 RRSRSP-RRRRRSRSRSRSRSRSRSRS-------RYSRSKSRSRTRS---RSRSTSKSRS 120 130 140 150 160 170 180 190 200 210 220 pF1KE0 PRRNFGSRGRSRSKSLQKRSKSIGKSQSSSPQKQTSSGTKSRSHGRHSDSIARSPCKSPK :: :...: : : ..::.: ..:.: :: .. .::::. ..:: :::. NP_003 ARR---SKSKSSSVS-RSRSRSRSRSRSRSPPPVSKRESKSRSR-------SKSPPKSPE 170 180 190 200 210 230 240 250 260 pF1KE0 GYTNSETKVQTAKHSHFRSHSRSRSYRHKNSW NP_003 EEGAVSS 220 >>NP_001182356 (OMIM: 600813) serine/arginine-rich splic (221 aa) initn: 646 init1: 285 opt: 445 Z-score: 270.2 bits: 57.4 E(85289): 2.6e-08 Smith-Waterman score: 459; 41.4% identity (63.7% similar) in 237 aa overlap (4-229:3-214) 10 20 30 40 50 pF1KE0 MSRYTRPPN-----TSLFIRNVADATRPEDLRREFGRYGPIVDVYIPLDFYTRRPRGFAY : ::: ::: . :.. : :. ::: : .:: . ::::: : ::.. ::::. NP_001 MSYGRPPPDVEGMTSLKVDNLTYRTSPDTLRRVFEKYGRVGDVYIPRDRYTKESRGFAF 10 20 30 40 50 60 70 80 90 100 pF1KE0 VQFEDVRDAEDALYNLNRKWVCGRQIEIQFAQGDRKTPGQMKSKERHPCSPSDH------ :.:.: ::::::. .. . ::....:.:. : : . .:.. : : . NP_001 VRFHDKRDAEDAMDAMDGAVLDGRELRVQMARYGRP-PDSHHSRRGPP--PRRYGGGGYG 60 70 80 90 100 110 110 120 130 140 150 160 pF1KE0 RRSRSPSQRRTRSRSSSWGRNRRRSDSLKESRHRRFSYSQSKSRSKSLPRRSTSARQSRT :::::: .:: :::: : .:.: :: : :.: :.:.::..: :: :. .::. NP_001 RRSRSP-RRRRRSRSRSRSRSRSRSRS-------RYSRSKSRSRTRS---RSRSTSKSRS 120 130 140 150 160 170 180 190 200 210 220 pF1KE0 PRRNFGSRGRSRSKSLQKRSKSIGKSQSSSPQKQTSSGTKSRSHGRHSDSIARSPCKSPK :: :...: : : ..::.: ..:.: :: .. .::::. ..:: :::. NP_001 ARR---SKSKSSSVS-RSRSRSRSRSRSRSPPPVSKRESKSRSR-------SKSPPKSPE 170 180 190 200 210 230 240 250 260 pF1KE0 GYTNSETKVQTAKHSHFRSHSRSRSYRHKNSW NP_001 EEGAVSS 220 261 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 18:21:30 2016 done: Sat Nov 5 18:21:31 2016 Total Scan time: 7.540 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]