Result of FASTA (omim) for
pF1KE0682
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0682, 389 aa
1>>>pF1KE0682 389 - 389 aa - 389 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 11.0668+/-0.000391; mu= -8.8230+/- 0.024
mean_var=372.3730+/-77.541, 0's: 0 Z-trim(122.8): 25 B-trim: 0 in 0/61
Lambda= 0.066464
statistics sampled from 41384 (41409) to 41384 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.799), E-opt: 0.2 (0.486), width: 16
Scan time: 8.940
The best scores are: opt bits E(85289)
NP_003966 (OMIM: 604514) SH2 domain-containing pro ( 389) 2739 276.2 9e-74
NP_001154916 (OMIM: 604514) SH2 domain-containing ( 389) 2739 276.2 9e-74
XP_006711678 (OMIM: 604514) PREDICTED: SH2 domain- ( 395) 2717 274.1 3.9e-73
XP_016858253 (OMIM: 604514) PREDICTED: SH2 domain- ( 385) 2694 271.9 1.8e-72
NP_001154914 (OMIM: 604514) SH2 domain-containing ( 371) 2584 261.4 2.6e-69
NP_001154915 (OMIM: 604514) SH2 domain-containing ( 361) 2541 257.2 4.4e-68
XP_016858252 (OMIM: 604514) PREDICTED: SH2 domain- ( 401) 2237 228.1 2.9e-59
XP_016858255 (OMIM: 604514) PREDICTED: SH2 domain- ( 377) 2160 220.7 4.6e-57
XP_016858254 (OMIM: 604514) PREDICTED: SH2 domain- ( 381) 2044 209.6 1e-53
NP_001154913 (OMIM: 604514) SH2 domain-containing ( 399) 2044 209.6 1.1e-53
XP_016858251 (OMIM: 604514) PREDICTED: SH2 domain- ( 405) 2044 209.6 1.1e-53
XP_016858256 (OMIM: 604514) PREDICTED: SH2 domain- ( 309) 956 105.2 2.2e-22
NP_116244 (OMIM: 608349) hematopoietic SH2 domain- ( 352) 344 46.5 0.00011
XP_011526692 (OMIM: 608349) PREDICTED: hematopoiet ( 187) 325 44.5 0.00025
XP_016882893 (OMIM: 608349) PREDICTED: hematopoiet ( 176) 324 44.4 0.00026
XP_016882892 (OMIM: 608349) PREDICTED: hematopoiet ( 218) 325 44.5 0.00028
XP_016882891 (OMIM: 608349) PREDICTED: hematopoiet ( 225) 325 44.6 0.00029
XP_011526688 (OMIM: 608349) PREDICTED: hematopoiet ( 405) 323 44.6 0.00051
>>NP_003966 (OMIM: 604514) SH2 domain-containing protein (389 aa)
initn: 2739 init1: 2739 opt: 2739 Z-score: 1445.4 bits: 276.2 E(85289): 9e-74
Smith-Waterman score: 2739; 100.0% identity (100.0% similar) in 389 aa overlap (1-389:1-389)
10 20 30 40 50 60
pF1KE0 MEFPLAQICPQGSHEAPIPTFSTFQITDMTRRSCQNLGYTAASPQAPEAASNTGNAERAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MEFPLAQICPQGSHEAPIPTFSTFQITDMTRRSCQNLGYTAASPQAPEAASNTGNAERAE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 EVPGEGSLFLQAETRAWFQKTQAHWLLQHGAAPAWFHGFITRREAERLLEPKPQGCYLVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 EVPGEGSLFLQAETRAWFQKTQAHWLLQHGAAPAWFHGFITRREAERLLEPKPQGCYLVR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 FSESAVTFVLTYRSRTCCRHFLLAQLRDGRHVVLGEDSAHARLQDLLLHYTAHPLSPYGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 FSESAVTFVLTYRSRTCCRHFLLAQLRDGRHVVLGEDSAHARLQDLLLHYTAHPLSPYGE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 TLTEPLARQTPEPAGLSLRTEESNFGSKSQDPNPQYSPIIKQGQAPVPMQKEGAGEKEPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 TLTEPLARQTPEPAGLSLRTEESNFGSKSQDPNPQYSPIIKQGQAPVPMQKEGAGEKEPS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 QLLRPKPPIPAKPQLPPEVYTIPVPRHRPAPRPKPSNPIYNEPDEPIAFYAMGRGSPGEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 QLLRPKPPIPAKPQLPPEVYTIPVPRHRPAPRPKPSNPIYNEPDEPIAFYAMGRGSPGEA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 PSNIYVEVEDEGLPATLGHPVLRKSWSRPVPGGQNTGGSQLHSENSVIGQGPPLPHQPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 PSNIYVEVEDEGLPATLGHPVLRKSWSRPVPGGQNTGGSQLHSENSVIGQGPPLPHQPPP
310 320 330 340 350 360
370 380
pF1KE0 AWRHTLPHNLSRQVLQDRGQAWLPLGPPQ
:::::::::::::::::::::::::::::
NP_003 AWRHTLPHNLSRQVLQDRGQAWLPLGPPQ
370 380
>>NP_001154916 (OMIM: 604514) SH2 domain-containing prot (389 aa)
initn: 2739 init1: 2739 opt: 2739 Z-score: 1445.4 bits: 276.2 E(85289): 9e-74
Smith-Waterman score: 2739; 100.0% identity (100.0% similar) in 389 aa overlap (1-389:1-389)
10 20 30 40 50 60
pF1KE0 MEFPLAQICPQGSHEAPIPTFSTFQITDMTRRSCQNLGYTAASPQAPEAASNTGNAERAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEFPLAQICPQGSHEAPIPTFSTFQITDMTRRSCQNLGYTAASPQAPEAASNTGNAERAE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 EVPGEGSLFLQAETRAWFQKTQAHWLLQHGAAPAWFHGFITRREAERLLEPKPQGCYLVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVPGEGSLFLQAETRAWFQKTQAHWLLQHGAAPAWFHGFITRREAERLLEPKPQGCYLVR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 FSESAVTFVLTYRSRTCCRHFLLAQLRDGRHVVLGEDSAHARLQDLLLHYTAHPLSPYGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FSESAVTFVLTYRSRTCCRHFLLAQLRDGRHVVLGEDSAHARLQDLLLHYTAHPLSPYGE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 TLTEPLARQTPEPAGLSLRTEESNFGSKSQDPNPQYSPIIKQGQAPVPMQKEGAGEKEPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLTEPLARQTPEPAGLSLRTEESNFGSKSQDPNPQYSPIIKQGQAPVPMQKEGAGEKEPS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 QLLRPKPPIPAKPQLPPEVYTIPVPRHRPAPRPKPSNPIYNEPDEPIAFYAMGRGSPGEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLLRPKPPIPAKPQLPPEVYTIPVPRHRPAPRPKPSNPIYNEPDEPIAFYAMGRGSPGEA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 PSNIYVEVEDEGLPATLGHPVLRKSWSRPVPGGQNTGGSQLHSENSVIGQGPPLPHQPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSNIYVEVEDEGLPATLGHPVLRKSWSRPVPGGQNTGGSQLHSENSVIGQGPPLPHQPPP
310 320 330 340 350 360
370 380
pF1KE0 AWRHTLPHNLSRQVLQDRGQAWLPLGPPQ
:::::::::::::::::::::::::::::
NP_001 AWRHTLPHNLSRQVLQDRGQAWLPLGPPQ
370 380
>>XP_006711678 (OMIM: 604514) PREDICTED: SH2 domain-cont (395 aa)
initn: 2725 init1: 2656 opt: 2717 Z-score: 1433.9 bits: 274.1 E(85289): 3.9e-73
Smith-Waterman score: 2717; 98.5% identity (98.5% similar) in 395 aa overlap (1-389:1-395)
10 20 30 40 50
pF1KE0 MEFPLAQICPQ------GSHEAPIPTFSTFQITDMTRRSCQNLGYTAASPQAPEAASNTG
::::::::::: :::::::::::::::::::::::::::::::::::::::::::
XP_006 MEFPLAQICPQALFVLTGSHEAPIPTFSTFQITDMTRRSCQNLGYTAASPQAPEAASNTG
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE0 NAERAEEVPGEGSLFLQAETRAWFQKTQAHWLLQHGAAPAWFHGFITRREAERLLEPKPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NAERAEEVPGEGSLFLQAETRAWFQKTQAHWLLQHGAAPAWFHGFITRREAERLLEPKPQ
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE0 GCYLVRFSESAVTFVLTYRSRTCCRHFLLAQLRDGRHVVLGEDSAHARLQDLLLHYTAHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GCYLVRFSESAVTFVLTYRSRTCCRHFLLAQLRDGRHVVLGEDSAHARLQDLLLHYTAHP
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE0 LSPYGETLTEPLARQTPEPAGLSLRTEESNFGSKSQDPNPQYSPIIKQGQAPVPMQKEGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LSPYGETLTEPLARQTPEPAGLSLRTEESNFGSKSQDPNPQYSPIIKQGQAPVPMQKEGA
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE0 GEKEPSQLLRPKPPIPAKPQLPPEVYTIPVPRHRPAPRPKPSNPIYNEPDEPIAFYAMGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GEKEPSQLLRPKPPIPAKPQLPPEVYTIPVPRHRPAPRPKPSNPIYNEPDEPIAFYAMGR
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE0 GSPGEAPSNIYVEVEDEGLPATLGHPVLRKSWSRPVPGGQNTGGSQLHSENSVIGQGPPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GSPGEAPSNIYVEVEDEGLPATLGHPVLRKSWSRPVPGGQNTGGSQLHSENSVIGQGPPL
310 320 330 340 350 360
360 370 380
pF1KE0 PHQPPPAWRHTLPHNLSRQVLQDRGQAWLPLGPPQ
:::::::::::::::::::::::::::::::::::
XP_006 PHQPPPAWRHTLPHNLSRQVLQDRGQAWLPLGPPQ
370 380 390
>>XP_016858253 (OMIM: 604514) PREDICTED: SH2 domain-cont (385 aa)
initn: 2425 init1: 2425 opt: 2694 Z-score: 1422.1 bits: 271.9 E(85289): 1.8e-72
Smith-Waterman score: 2694; 99.0% identity (99.0% similar) in 389 aa overlap (1-389:1-385)
10 20 30 40 50 60
pF1KE0 MEFPLAQICPQGSHEAPIPTFSTFQITDMTRRSCQNLGYTAASPQAPEAASNTGNAERAE
:::::::::::::::::::::::::::::::::::::::::: ::::::::::::::
XP_016 MEFPLAQICPQGSHEAPIPTFSTFQITDMTRRSCQNLGYTAA----PEAASNTGNAERAE
10 20 30 40 50
70 80 90 100 110 120
pF1KE0 EVPGEGSLFLQAETRAWFQKTQAHWLLQHGAAPAWFHGFITRREAERLLEPKPQGCYLVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EVPGEGSLFLQAETRAWFQKTQAHWLLQHGAAPAWFHGFITRREAERLLEPKPQGCYLVR
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE0 FSESAVTFVLTYRSRTCCRHFLLAQLRDGRHVVLGEDSAHARLQDLLLHYTAHPLSPYGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FSESAVTFVLTYRSRTCCRHFLLAQLRDGRHVVLGEDSAHARLQDLLLHYTAHPLSPYGE
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE0 TLTEPLARQTPEPAGLSLRTEESNFGSKSQDPNPQYSPIIKQGQAPVPMQKEGAGEKEPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLTEPLARQTPEPAGLSLRTEESNFGSKSQDPNPQYSPIIKQGQAPVPMQKEGAGEKEPS
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE0 QLLRPKPPIPAKPQLPPEVYTIPVPRHRPAPRPKPSNPIYNEPDEPIAFYAMGRGSPGEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLLRPKPPIPAKPQLPPEVYTIPVPRHRPAPRPKPSNPIYNEPDEPIAFYAMGRGSPGEA
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE0 PSNIYVEVEDEGLPATLGHPVLRKSWSRPVPGGQNTGGSQLHSENSVIGQGPPLPHQPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSNIYVEVEDEGLPATLGHPVLRKSWSRPVPGGQNTGGSQLHSENSVIGQGPPLPHQPPP
300 310 320 330 340 350
370 380
pF1KE0 AWRHTLPHNLSRQVLQDRGQAWLPLGPPQ
:::::::::::::::::::::::::::::
XP_016 AWRHTLPHNLSRQVLQDRGQAWLPLGPPQ
360 370 380
>>NP_001154914 (OMIM: 604514) SH2 domain-containing prot (371 aa)
initn: 2584 init1: 2584 opt: 2584 Z-score: 1365.3 bits: 261.4 E(85289): 2.6e-69
Smith-Waterman score: 2584; 100.0% identity (100.0% similar) in 368 aa overlap (22-389:4-371)
10 20 30 40 50 60
pF1KE0 MEFPLAQICPQGSHEAPIPTFSTFQITDMTRRSCQNLGYTAASPQAPEAASNTGNAERAE
:::::::::::::::::::::::::::::::::::::::
NP_001 MSPSTFQITDMTRRSCQNLGYTAASPQAPEAASNTGNAERAE
10 20 30 40
70 80 90 100 110 120
pF1KE0 EVPGEGSLFLQAETRAWFQKTQAHWLLQHGAAPAWFHGFITRREAERLLEPKPQGCYLVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVPGEGSLFLQAETRAWFQKTQAHWLLQHGAAPAWFHGFITRREAERLLEPKPQGCYLVR
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE0 FSESAVTFVLTYRSRTCCRHFLLAQLRDGRHVVLGEDSAHARLQDLLLHYTAHPLSPYGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FSESAVTFVLTYRSRTCCRHFLLAQLRDGRHVVLGEDSAHARLQDLLLHYTAHPLSPYGE
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE0 TLTEPLARQTPEPAGLSLRTEESNFGSKSQDPNPQYSPIIKQGQAPVPMQKEGAGEKEPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLTEPLARQTPEPAGLSLRTEESNFGSKSQDPNPQYSPIIKQGQAPVPMQKEGAGEKEPS
170 180 190 200 210 220
250 260 270 280 290 300
pF1KE0 QLLRPKPPIPAKPQLPPEVYTIPVPRHRPAPRPKPSNPIYNEPDEPIAFYAMGRGSPGEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLLRPKPPIPAKPQLPPEVYTIPVPRHRPAPRPKPSNPIYNEPDEPIAFYAMGRGSPGEA
230 240 250 260 270 280
310 320 330 340 350 360
pF1KE0 PSNIYVEVEDEGLPATLGHPVLRKSWSRPVPGGQNTGGSQLHSENSVIGQGPPLPHQPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSNIYVEVEDEGLPATLGHPVLRKSWSRPVPGGQNTGGSQLHSENSVIGQGPPLPHQPPP
290 300 310 320 330 340
370 380
pF1KE0 AWRHTLPHNLSRQVLQDRGQAWLPLGPPQ
:::::::::::::::::::::::::::::
NP_001 AWRHTLPHNLSRQVLQDRGQAWLPLGPPQ
350 360 370
>>NP_001154915 (OMIM: 604514) SH2 domain-containing prot (361 aa)
initn: 2541 init1: 2541 opt: 2541 Z-score: 1343.2 bits: 257.2 E(85289): 4.4e-68
Smith-Waterman score: 2541; 100.0% identity (100.0% similar) in 361 aa overlap (29-389:1-361)
10 20 30 40 50 60
pF1KE0 MEFPLAQICPQGSHEAPIPTFSTFQITDMTRRSCQNLGYTAASPQAPEAASNTGNAERAE
::::::::::::::::::::::::::::::::
NP_001 MTRRSCQNLGYTAASPQAPEAASNTGNAERAE
10 20 30
70 80 90 100 110 120
pF1KE0 EVPGEGSLFLQAETRAWFQKTQAHWLLQHGAAPAWFHGFITRREAERLLEPKPQGCYLVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVPGEGSLFLQAETRAWFQKTQAHWLLQHGAAPAWFHGFITRREAERLLEPKPQGCYLVR
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE0 FSESAVTFVLTYRSRTCCRHFLLAQLRDGRHVVLGEDSAHARLQDLLLHYTAHPLSPYGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FSESAVTFVLTYRSRTCCRHFLLAQLRDGRHVVLGEDSAHARLQDLLLHYTAHPLSPYGE
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE0 TLTEPLARQTPEPAGLSLRTEESNFGSKSQDPNPQYSPIIKQGQAPVPMQKEGAGEKEPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLTEPLARQTPEPAGLSLRTEESNFGSKSQDPNPQYSPIIKQGQAPVPMQKEGAGEKEPS
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE0 QLLRPKPPIPAKPQLPPEVYTIPVPRHRPAPRPKPSNPIYNEPDEPIAFYAMGRGSPGEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLLRPKPPIPAKPQLPPEVYTIPVPRHRPAPRPKPSNPIYNEPDEPIAFYAMGRGSPGEA
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE0 PSNIYVEVEDEGLPATLGHPVLRKSWSRPVPGGQNTGGSQLHSENSVIGQGPPLPHQPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSNIYVEVEDEGLPATLGHPVLRKSWSRPVPGGQNTGGSQLHSENSVIGQGPPLPHQPPP
280 290 300 310 320 330
370 380
pF1KE0 AWRHTLPHNLSRQVLQDRGQAWLPLGPPQ
:::::::::::::::::::::::::::::
NP_001 AWRHTLPHNLSRQVLQDRGQAWLPLGPPQ
340 350 360
>>XP_016858252 (OMIM: 604514) PREDICTED: SH2 domain-cont (401 aa)
initn: 2303 init1: 2037 opt: 2237 Z-score: 1185.1 bits: 228.1 E(85289): 2.9e-59
Smith-Waterman score: 2642; 95.1% identity (95.1% similar) in 405 aa overlap (1-389:1-401)
10 20 30 40 50
pF1KE0 MEFPLAQICPQ------GSHEAPIPTFSTFQITDMTRRSCQNLGYTAASPQAPEAASNTG
::::::::::: ::::::::::::::::::::::::::::::: ::::::::
XP_016 MEFPLAQICPQALFVLTGSHEAPIPTFSTFQITDMTRRSCQNLGYTAA----PEAASNTG
10 20 30 40 50
60 70 80 90 100
pF1KE0 NAERAEEVPGEGSLFLQAETRAWFQKTQAHWLLQHGAAPAWFHGFITRR----------E
::::::::::::::::::::::::::::::::::::::::::::::::: :
XP_016 NAERAEEVPGEGSLFLQAETRAWFQKTQAHWLLQHGAAPAWFHGFITRRVRPPLSVTHRE
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE0 AERLLEPKPQGCYLVRFSESAVTFVLTYRSRTCCRHFLLAQLRDGRHVVLGEDSAHARLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AERLLEPKPQGCYLVRFSESAVTFVLTYRSRTCCRHFLLAQLRDGRHVVLGEDSAHARLQ
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE0 DLLLHYTAHPLSPYGETLTEPLARQTPEPAGLSLRTEESNFGSKSQDPNPQYSPIIKQGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLLLHYTAHPLSPYGETLTEPLARQTPEPAGLSLRTEESNFGSKSQDPNPQYSPIIKQGQ
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE0 APVPMQKEGAGEKEPSQLLRPKPPIPAKPQLPPEVYTIPVPRHRPAPRPKPSNPIYNEPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APVPMQKEGAGEKEPSQLLRPKPPIPAKPQLPPEVYTIPVPRHRPAPRPKPSNPIYNEPD
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE0 EPIAFYAMGRGSPGEAPSNIYVEVEDEGLPATLGHPVLRKSWSRPVPGGQNTGGSQLHSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EPIAFYAMGRGSPGEAPSNIYVEVEDEGLPATLGHPVLRKSWSRPVPGGQNTGGSQLHSE
300 310 320 330 340 350
350 360 370 380
pF1KE0 NSVIGQGPPLPHQPPPAWRHTLPHNLSRQVLQDRGQAWLPLGPPQ
:::::::::::::::::::::::::::::::::::::::::::::
XP_016 NSVIGQGPPLPHQPPPAWRHTLPHNLSRQVLQDRGQAWLPLGPPQ
360 370 380 390 400
>>XP_016858255 (OMIM: 604514) PREDICTED: SH2 domain-cont (377 aa)
initn: 2162 init1: 2037 opt: 2160 Z-score: 1145.5 bits: 220.7 E(85289): 4.6e-57
Smith-Waterman score: 2509; 96.3% identity (96.3% similar) in 378 aa overlap (22-389:4-377)
10 20 30 40 50 60
pF1KE0 MEFPLAQICPQGSHEAPIPTFSTFQITDMTRRSCQNLGYTAASPQAPEAASNTGNAERAE
::::::::::::::::::::: ::::::::::::::
XP_016 MSPSTFQITDMTRRSCQNLGYTAA----PEAASNTGNAERAE
10 20 30
70 80 90 100 110
pF1KE0 EVPGEGSLFLQAETRAWFQKTQAHWLLQHGAAPAWFHGFITRR----------EAERLLE
::::::::::::::::::::::::::::::::::::::::::: :::::::
XP_016 EVPGEGSLFLQAETRAWFQKTQAHWLLQHGAAPAWFHGFITRRVRPPLSVTHREAERLLE
40 50 60 70 80 90
120 130 140 150 160 170
pF1KE0 PKPQGCYLVRFSESAVTFVLTYRSRTCCRHFLLAQLRDGRHVVLGEDSAHARLQDLLLHY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PKPQGCYLVRFSESAVTFVLTYRSRTCCRHFLLAQLRDGRHVVLGEDSAHARLQDLLLHY
100 110 120 130 140 150
180 190 200 210 220 230
pF1KE0 TAHPLSPYGETLTEPLARQTPEPAGLSLRTEESNFGSKSQDPNPQYSPIIKQGQAPVPMQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TAHPLSPYGETLTEPLARQTPEPAGLSLRTEESNFGSKSQDPNPQYSPIIKQGQAPVPMQ
160 170 180 190 200 210
240 250 260 270 280 290
pF1KE0 KEGAGEKEPSQLLRPKPPIPAKPQLPPEVYTIPVPRHRPAPRPKPSNPIYNEPDEPIAFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KEGAGEKEPSQLLRPKPPIPAKPQLPPEVYTIPVPRHRPAPRPKPSNPIYNEPDEPIAFY
220 230 240 250 260 270
300 310 320 330 340 350
pF1KE0 AMGRGSPGEAPSNIYVEVEDEGLPATLGHPVLRKSWSRPVPGGQNTGGSQLHSENSVIGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AMGRGSPGEAPSNIYVEVEDEGLPATLGHPVLRKSWSRPVPGGQNTGGSQLHSENSVIGQ
280 290 300 310 320 330
360 370 380
pF1KE0 GPPLPHQPPPAWRHTLPHNLSRQVLQDRGQAWLPLGPPQ
:::::::::::::::::::::::::::::::::::::::
XP_016 GPPLPHQPPPAWRHTLPHNLSRQVLQDRGQAWLPLGPPQ
340 350 360 370
>>XP_016858254 (OMIM: 604514) PREDICTED: SH2 domain-cont (381 aa)
initn: 2037 init1: 2037 opt: 2044 Z-score: 1085.4 bits: 209.6 E(85289): 1e-53
Smith-Waterman score: 2554; 97.4% identity (97.4% similar) in 378 aa overlap (22-389:4-381)
10 20 30 40 50 60
pF1KE0 MEFPLAQICPQGSHEAPIPTFSTFQITDMTRRSCQNLGYTAASPQAPEAASNTGNAERAE
:::::::::::::::::::::::::::::::::::::::
XP_016 MSPSTFQITDMTRRSCQNLGYTAASPQAPEAASNTGNAERAE
10 20 30 40
70 80 90 100 110
pF1KE0 EVPGEGSLFLQAETRAWFQKTQAHWLLQHGAAPAWFHGFITRR----------EAERLLE
::::::::::::::::::::::::::::::::::::::::::: :::::::
XP_016 EVPGEGSLFLQAETRAWFQKTQAHWLLQHGAAPAWFHGFITRRVRPPLSVTHREAERLLE
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE0 PKPQGCYLVRFSESAVTFVLTYRSRTCCRHFLLAQLRDGRHVVLGEDSAHARLQDLLLHY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PKPQGCYLVRFSESAVTFVLTYRSRTCCRHFLLAQLRDGRHVVLGEDSAHARLQDLLLHY
110 120 130 140 150 160
180 190 200 210 220 230
pF1KE0 TAHPLSPYGETLTEPLARQTPEPAGLSLRTEESNFGSKSQDPNPQYSPIIKQGQAPVPMQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TAHPLSPYGETLTEPLARQTPEPAGLSLRTEESNFGSKSQDPNPQYSPIIKQGQAPVPMQ
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE0 KEGAGEKEPSQLLRPKPPIPAKPQLPPEVYTIPVPRHRPAPRPKPSNPIYNEPDEPIAFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KEGAGEKEPSQLLRPKPPIPAKPQLPPEVYTIPVPRHRPAPRPKPSNPIYNEPDEPIAFY
230 240 250 260 270 280
300 310 320 330 340 350
pF1KE0 AMGRGSPGEAPSNIYVEVEDEGLPATLGHPVLRKSWSRPVPGGQNTGGSQLHSENSVIGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AMGRGSPGEAPSNIYVEVEDEGLPATLGHPVLRKSWSRPVPGGQNTGGSQLHSENSVIGQ
290 300 310 320 330 340
360 370 380
pF1KE0 GPPLPHQPPPAWRHTLPHNLSRQVLQDRGQAWLPLGPPQ
:::::::::::::::::::::::::::::::::::::::
XP_016 GPPLPHQPPPAWRHTLPHNLSRQVLQDRGQAWLPLGPPQ
350 360 370 380
>>NP_001154913 (OMIM: 604514) SH2 domain-containing prot (399 aa)
initn: 2037 init1: 2037 opt: 2044 Z-score: 1085.1 bits: 209.6 E(85289): 1.1e-53
Smith-Waterman score: 2709; 97.5% identity (97.5% similar) in 399 aa overlap (1-389:1-399)
10 20 30 40 50 60
pF1KE0 MEFPLAQICPQGSHEAPIPTFSTFQITDMTRRSCQNLGYTAASPQAPEAASNTGNAERAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEFPLAQICPQGSHEAPIPTFSTFQITDMTRRSCQNLGYTAASPQAPEAASNTGNAERAE
10 20 30 40 50 60
70 80 90 100 110
pF1KE0 EVPGEGSLFLQAETRAWFQKTQAHWLLQHGAAPAWFHGFITRR----------EAERLLE
::::::::::::::::::::::::::::::::::::::::::: :::::::
NP_001 EVPGEGSLFLQAETRAWFQKTQAHWLLQHGAAPAWFHGFITRRVRPPLSVTHREAERLLE
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE0 PKPQGCYLVRFSESAVTFVLTYRSRTCCRHFLLAQLRDGRHVVLGEDSAHARLQDLLLHY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PKPQGCYLVRFSESAVTFVLTYRSRTCCRHFLLAQLRDGRHVVLGEDSAHARLQDLLLHY
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE0 TAHPLSPYGETLTEPLARQTPEPAGLSLRTEESNFGSKSQDPNPQYSPIIKQGQAPVPMQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TAHPLSPYGETLTEPLARQTPEPAGLSLRTEESNFGSKSQDPNPQYSPIIKQGQAPVPMQ
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE0 KEGAGEKEPSQLLRPKPPIPAKPQLPPEVYTIPVPRHRPAPRPKPSNPIYNEPDEPIAFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KEGAGEKEPSQLLRPKPPIPAKPQLPPEVYTIPVPRHRPAPRPKPSNPIYNEPDEPIAFY
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE0 AMGRGSPGEAPSNIYVEVEDEGLPATLGHPVLRKSWSRPVPGGQNTGGSQLHSENSVIGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AMGRGSPGEAPSNIYVEVEDEGLPATLGHPVLRKSWSRPVPGGQNTGGSQLHSENSVIGQ
310 320 330 340 350 360
360 370 380
pF1KE0 GPPLPHQPPPAWRHTLPHNLSRQVLQDRGQAWLPLGPPQ
:::::::::::::::::::::::::::::::::::::::
NP_001 GPPLPHQPPPAWRHTLPHNLSRQVLQDRGQAWLPLGPPQ
370 380 390
389 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 02:45:30 2016 done: Sat Nov 5 02:45:31 2016
Total Scan time: 8.940 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]